Dr. David Coghlan

Dr. David Coghlan

Clinical Associate Professor, Paediatrics

Clinical Associate Professor

3531896 3763/3763

Publications and Further Research Outputs

  • Scanlan B, Nadeem M, Ryan M, Smith O, O'Marcaigh A, Coghlan D, Acute leukaemia presenting with isolated bone pain, Archives of Disease in Childhood, 98 , (10), 2013, 771-Journal Article, 2013, DOI
  • Kerley CP, Hutchinson K, Cormican L, Faul J, Greally P, Coghlan D, Elnazir B, Vitamin D3 for uncontrolled childhood asthma: a pilot study, Pediatric Allergy and Immunology 27 (4), 404-412 , 2016Journal Article, 2016, DOI
  • Murphy K, Scanlan B, Coghlan D, Does this child really have a penicillin allergy?, Ir Med J, 2015Journal Article, 2015
  • Cunningham K, Scanlan B, Coghlan D, Quinn S, Infants with FPIES to solid food proteins--chicken, rice and oats, Ir Med J., 2014Journal Article, 2014
  • Nadeem M, Oni OA, Ryan M, Puri P, Coghlan D, Greally P, Girl with xanthogranulomatous pyelonephritis and bronchiectasis: case report., Pediatrics international : official journal of the Japan Pediatric Society, 2013Journal Article, 2013, DOI , URL
  • Deasy C, O'Mahony O, Coghlan D, Fitzgerald E, Isoparaffin poisoning in an 18-month-old girl., Ir Med J, 2007Journal Article, 2007
  • McManus V, Coghlan D, Are hospital based notifications enough? Achieving accurate case ascertainment--the Southern Ireland Cerebral Palsy Register (SICPR), Ir Med J, 2005Journal Article, 2005
  • Cans C, Surman G, McManus V, Coghlan D, Hensey O, Johnson A, Cerebral palsy registries., 2004Journal Article, 2004
  • Coghlan D, Powell C, Treatment of childhood asthma: how do the available options compare?, Pediatric Drugs 5 (10), 685-698 , 2003Journal Article, 2003
  • Coghlan D, Kiing JS, Wake M, Parents' Evaluation of Developmental Status in the Australian day-care setting: developmental concerns of parents and carers., Journal of Paediatrics and Child Health 39 (1), 49-54, 2003Journal Article, 2003
  • Coghlan D, Lynch B, Allcutt D, Hereditary cerebral cavernous angiomas: presentation as idiopathic familial epilepsy, Ir Med J, 2002Journal Article, 2002
  • Coghlan D, Cranswick NE, Complementary medicine and vitamin A toxicity in children, Medical Journal of Australia , 2001Journal Article, 2001
  • Wake M, Coghlan D, Hesketh K, Does height influence progression through primary school grades?, Arch Dis Child, 2000Journal Article, 2000
  • Cranswick N, Coghlan D, Paracetamol efficacy and safety in children: the first 40 years., American Journal of Therapeutics, 2000Journal Article, 2000
  • Coghlan D, Milner M, Clarke T, Lambert I, McDermott C, McNally M, Beckett M, Matthews T, Neonatal abstinence syndrome, Ir Med J, 1999Journal Article, 1999
  • Kenosi M, Whitla L, Khan N, Carty E, Coghlan D, Nadeem M, Interpretation of pyuria in children with urinary tract infection , Acta paediatrica (Oslo, Norway : 1992) , 107, (2), 2018, p358-Journal Article, 2018, DOI , URL
  • Macken WL, Clarke N, Nadeem M, Coghlan D, Life After the Event: A Review of Basic Life Support Training for Parents Following Apparent Life-Threatening Events and Their Experience and Practices Following Discharge , Irish Medical Journal, 110 , (5 ), 2017, p572 - 574Journal Article, 2017, URL
  • Tamgumus S, Geoghan J, Coghlan D, Nadeem M, Urinary Tract Infection in Childhood and Inflammatory Markers, Irish Medical Journal, 109 , (7 ), 2016, p442 -Journal Article, 2016, URL
  • Khan N, Whitla L, Kenosi M, Coghlan D, Nadeem M, Follow up chest radiography in paediatric pneumonia: is it avoidable? , Irish Medical Journal, 2018Journal Article, 2018, URL
  • Rutledge E, Whitla L, Coghlan D, Nadeem M, Peripheral White Blood Cell Differential Counts In Children With UTI, Is There A Link?, Irish Medical Journal, 111, (6), 2018Journal Article, 2018, URL
  • Hutchinson K, Kerley CP, Faul J, Greally P, Coghlan D, Louw M, Elnazir B, Rochev Y. , Vitamin D receptor variants and uncontrolled asthma , Eur Ann Allergy Clin Immunol. 2018 , 2018Journal Article, 2018, DOI
  • Kerley CP, Power C, Gallagher L, Coghlan D , Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT, Arch Dis Child 2017 , 2017Journal Article, 2017, DOI
  • Kerley CP, Elnazir B, Greally P, Coghlan D. , Blunted serum 25(OH)D response to vitamin D3 supplementation in children with autism, Nutr Neurosci. , 2018Journal Article, 2018, DOI
  • Reynolds A, O'Driscoll J, Quinn S, Coghlan D. , Cows Milk Allergy: A Cohort of Patients from a University Hospital, Ir Med J. , 2016Journal Article, 2016
  • J O'Brien, EB Williams, D Coghlan, Is ultrasound a useful tool in the diagnosis of failure to thrive? Preliminary findings from the faltering growth (FIG) study , Irish journal of medical science 179, S204-S204, 2010Journal Article, 2010
  • M Curtin, D Coghlan , Missed vaccines, missed opportunity , Irish Journal of Medical Science , 2010Journal Article, 2010
  • CW Teoh, M Mavinkurve, U Damachi, S Medani, M Waldron, D Coghlan , Vesico-ureteric reflux and renal scarring in children under 1 year of age with first urinary tract infection , PEDIATRIC NEPHROLOGY , 2011Journal Article, 2011
  • M White, E Williams, M Curtin, D Coghlan , Smaller size and its developmental associations , Acta Paediatrica, 2009Journal Article, 2009
  • M Omer, EB Williams, D Coghlan, How useful is the measurement of crp, total white cell and neutrophil counts in differentiating between bacterial and other causes of fever in children? , Irish Journal of Medical Science , 2010Journal Article, 2010
  • C Howard, WL Macken, A Connolly, M Keegan, D Coghlan, DW Webb, Percutaneous endoscopic gastrostomy for refractory epilepsy and medication refusal, Arch Dis Child, 2019Journal Article, 2019, DOI
  • Cerebral Palsy Registries in, Seminars in Pediatric Neurology , Seminars in Pediatric Neurology 1, 2004, pp18 - 23, [C Cans, G Surman, V McManus, D Coghlan, O Hensey, A Johnson ]Book Chapter, 2004
  • M Alsaffar, N Gadelsayed, D Coghlan, Molloy E, Prevalence of Coeliac Disease in Children with Down syndrome, Archives of Disease in Childhood 2017;102:A106., Pediatric Academic Societies (PAS) 2017 Meeting, May 6 - 9, in San Francisco, CA.Meeting Abstract, San Francisco, 2017, 102, 2017Meeting Abstract, 2017
  • WL Macken, D Coghlan, N Montasseur, An audit of basic life support training for parents following apparent life threatening events (ALTE) in early childhood., IPA, 2015, 2015Meeting Abstract, 2015
  • N Khan, D Coghlan, N Gadelsayed, Follow Up Chest Radiography in Paediatric Pneumonia: Is It Avoidable? , IPA, 2017Meeting Abstract, 2017
  • E Carty, D Coghlan, N Gadelsayed, Interpretation of pyuria in children with urinary tract infection, IPA, 2017Meeting Abstract, 2017
  • S Neville, N Gadelsayed, D Coghlan, Working to implement guidelines for UTI assessment and management: the "Wiguam" quality improvement initiative , Irish Paediatric Association , 2017, 2017Meeting Abstract, 2017
  • N Gadelsayed, D Coghlan, Case series of herpes simplex virus meningoencephalitis in a single paediatric centre over a 10-year period , Joint IPA/Welsh Paediatric Society , 2018, 2018Meeting Abstract, 2018
  • N Gadelsayed, D Coghlan, Influenza in children; is there a pattern of adverse outcomes and are inflammatory markers predictive?, Joint Irish Paediatric Association/Welsh Paediatric Society Meeting 2018, 2018Meeting Abstract, 2018
  • S Tamgumus, J Geoghegan, D Coghlan, M Nadeem. , Urinary tract infection in childhood and inflammatory markers , IPA, 2016Meeting Abstract, 2016
  • CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , A randomized, double-blind, placebo-controlled of Vitamin D3 for Irish children with asthma , Nutrition Society, 2015Meeting Abstract, 2015
  • CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir , The Effects of Vitamin D Supplementation on Pulmonary Function, Disease Severity and Markers of Inflammation in Childhood Asthmatics: A Randomized, Double-Blind, Placebo , IPA, 2014Meeting Abstract, 2014
  • CP Kerley, K Hutchinson, P Greally, D Coghlan, B Elnazir (ed.), Proceedings of the Nutrition Society 73 (OCE2), 2014, 2014Proceedings of a Conference, 2014
  • D. Coghlan, U. Murtagh, M. Nadeem, Integration of Two Acute Paediatric Services During COVID-19, Ir Med J, 114, (4), 2021, p324Journal Article, 2021, URL
  • Byrne AM, Trujillo J, Fitzsimons j... Coghlan D., Mass food challenges in a vacant COVID-19 stepdown facility: Exceptional opportunity provides a model for the future, Pediatr Allergy Immunol. 2021, 2021Journal Article, 2021, DOI , URL
  • Coghlan D, Management of anaphylaxis in children undergoing oral food challenges in an adapted COVID-19 field hospital, Archives of Disease in Childhood, 2021Journal Article, 2021, DOI
  • Coghlan D, What does 'PEWing' or 'PEWsing' mean? A new word in paediatrics. Diskin C, MacDonell R, Whelan B, O' Shea O, Fitzsimons JJ, Vaughan D, Coghlan D. Arch Dis Child. 2020 May;105(5):518-519. doi: 10.1136/archdischild-2019-318252. Epub 2019 Nov 20, Achives of Disease in Childhood, (105(5):), 2020, p518 - 519Journal Article, 2020, URL
  • Coghlan D, Priorities for child health research across the UK and Ireland. , Archives ofr Disease in Childhood, 107, (5), 2022, p474 - 478Journal Article, 2022, DOI
  • J Dinsmore, E Williams, H McCarthy, D Coghlan Journal of Human Nutrition and Dietetics 24 (3), 280-281, A pilot study to explore factors affecting faltering growth in children , Journal of Human Nutrition and Dietetics 24 (3), 280-281, 2011Journal Article

Research Expertise

General Paediatrics is an acute specialty caring for the undifferentiated child. It is an emerging academic specialty with a focus on clinical research and quality improvement. Since my time as a fellow at RCH Melbourne I concentrated on early child development and how clinicians and parents must collaborate to define a child's abilities in the home, school and play settings. This work included those with developmental delay and those with more severe disabilities such as cerebral palsy. More recent work has focused on interventions including Vitamin D supplementation to improve symptoms in children with Autism and Asthma. While adequate nutrition is essential many child still require daily medication and my work has also looked at improving methods of medication administration in those with acute infection, allergy and complex needs. A novel method of delivering anti-epileptic method through a feeding tube was described with great benefits for children with complex needs. Randomised Controlled trials: 1. RCT of Vitamin D supplementation in autism spectrum disorder. Randomised 42 children to receive 2000 IU Vitamin D3 daily or placebo over 20 weeks. Vitamin D had no effect on primary outcome of reducing stereotypic autistic behaviours. Trend towards reduced inappropriate speech in the Vitamin D3 treatment group. 2. RCT of Vitamin D supplementation in uncontrolled asthma. Randomised 44 children with uncontrolled asthma to receive 2000 IU Vitamin D3 or placebo over 15 weeks. Vitamin D had no effect on primary outcome of improved subjective asthma control or Fev1 on spirometry. There was a non significant improvement in Fev1 within the placebo group. 3. EVITA Trial (NIHR UK) 2024. A 3 way trial exploring equipoise between intravenous magnesium sulphate, salbutamol, and aminophyllin in children with severe acute asthma. Awaits funding Finally we've explored variation in medication response by examining genetic variants in asthma. An association was found between Taql (exon 9) and Apal (intron 8) polymorphisms and asthma risk. IL10 levels were lower in asthmatic children with Taql polymorphisms. I've also developed national guidelines published as the WIGUAM Study (Working to Implement National Guidelines for Urine Tract Infection Assessment and Management ).

  • Title
    An RCT of Vitamin D3 in Paediatric Autism
    Summary
    A double-blind, randomised, placebo-controlled trial set in a paediatric outpatient centre at high latitude over the winter season in Dublin, Ireland (53°N). Conclusion: Vitamin D supplementation had no effect on the primary outcome with limited and inconsistent effects in children with ASD. Considering the other promising data as well as the relative safety and cheapness of vitamin D supplementation, further trials are warranted.
    Funding Agency
    The National Children's Hospital Foundation
    Date From
    Jan 2015
    Date To
    Jan 2016
  • Title
    FIG Study
    Summary
    Faltering growth In General paediatrics Clinic (FIG) was a 1 year study exploring the determinants of poor growth in toddlers. The effect of maternal and social factors on faltering growth (FG) are unclear from published research. A control comparison of 24 children recruited through clinics in AMNCH was undertaken (12 FG, 12 controls). Participating parents completed a health, social,and demographic questionnaire and a 7 day food diary was completed using household measures. Diaries were analysed using NETWISP for protein , fat, carbohydrate, and vitamin content. All data were entered in SPSS. There were no significant difference between FG and control groups in maternal health or social factors. There were no differences in the feeding histories between the two groups. However the mean intake of all nutrients except protein, monounsaturated fat, starch, sodium and B12 were all higher in the control group. These findings support hypothesis that poor nutritional intake is main cause of faltering growth in this group. There was a trend towards lower breast feeding rates in the FG group.
    Funding Agency
    NCH Foundation
    Date From
    2009
    Date To
    2010
  • Title
    Protocol for Investigation of Penicillin Allergy.
    Summary
    Feasibility Study to Implement National Protocol for Investigation of Penicillin Allergy in children
    Funding Agency
    The National Children's Hospital Foundation
    Date From
    April 2012
    Date To
    April 2013
  • Title
    Bright Horizons Study
    Summary
    Bright Horizons Study. Neurodevelopmental follow up of preterm infants including psychological profiling at age 24 months corrected. Also to investigate the developmental outcomes of children with a history of HIE (Hypoxic Ischemic Encephalopathy).
    Funding Agency
    NCH Foundation
    Date From
    2015
    Date To
    2017
  • Title
    PROSPER: PaediatRic Outcomes and Serum biomarker Panel in acutE traumatic bRain injury /concussion to severe traumatic 2015-9.
    Summary
    To describe the demographics and aetiology of traumatic brain injury presenting to Irish Paediatric Emergency Departments. Concussion and mild traumatic brain injury (mTBI) are interchangeable terms.Post-concussion syndrome (PCS) occurs in 1/7 children sustaining a mTBI.Secondly to describe physician competence in this condition and to develop a best practice guideline. To elucidate biomarkers from the innate immune system that are activated in acute brain injury. Findings include preschool children have the highest incidence of head injury, mostly following a fall. There was a paucity of knowledge among all grades of medical professionals in how to manage these children. Many patients had a raised white cell count with neutrophilia. Surprisingly CD 11b neutrophil expression was not raised in mTBI on flow cytometry, but was markedly raised in the 4 most severe TBI patients.
    Funding Agency
    National Children's Hospital Foundation
    Date From
    2016
    Date To
    2019
  • Title
    PRISM: PReterm Infection and SysteMic inflammation and neonatal outcomes.
    Summary
    This research aims to improve the understanding of the systemic inflammatory response in preterm infants and the potential for newer adjunctive therapies. In addition trying to identify immune markers that will assist in the prognosis and clinical outcomes of these preterm infants.
    Funding Agency
    The National Children's Hospital Foundation and Trinity College Dublin
    Date From
    2016
    Date To
    2019
  • Title
    An RCT of Vitamin D3 in Uncontrolled Asthma
    Summary
    A double-blind, randomized, PL-controlled trial of vitamin D supplementation (2000 IU/day) in 44 urban, caucasian children at high latitude. Conclusion: Vitamin D3 supplementation led to a significant increase in serum 25(OH)D and decreased school days missed (p = 0.04), but no other advantageous changes in asthma parameters compared with PL.The potential negative effect of high serum 25(OH)D on pulmonary function warrant further investigation.
    Funding Agency
    National Children's Hospital Foundation
    Date From
    January 2014
    Date To
    January 2015

Immunity and Infection (including Rheumatology & Inflammatory disease),

Recognition

  • Irish Paediatric Association (IPA)- Best Oral Presentation WIGUAM Study 2017
  • Paediatrician of the Year-Laya Healthcare Awards 2015
  • IPA-Best Poster "FPIES in infancy" 2015
  • FRCPI-Fellow of the Royal College of Physicians, Ireland 2019
  • GAPRUKI Collaboration-General and Adolescent Paediatrics UK and Ireland Member(Research Collaboration Body) -Founding member 2019
  • FRCPCH (UK)-Fellow of the Royal College of Physicians and Child Health 2019
  • Irish Paediatric Surveillance Unit (IPSU) 2019
  • ERS-European Respiratory Society Member 2019
  • Faculty of Paediatrics, RCPI 2019
  • British Paediatric Surveillance Unit (BPSU) 2019
  • EAACI, European Academy of Allergy and Immunology, Member 2019
  • MPS-Medical Protection Society Member 2019
  • Expert external case reviewer supporting Director Of Quality, CHI (Children's Hospital Ireland) 2018
  • HSE-Acute Floor Implementation Process Group( Paediatric Representative) 2018
  • Chair, National Guideline Committee -Management of Urinary Tract Infection in children 2015
  • Paediatric Clinical Advisor, Coeliac Society of Ireland 2018
  • Reviewer for Irish Medical Journal 2015
  • Paediatric expert reviewer for Irish Medical Council 2016
  • National Electronic Health Record (EHR) Programme. Paediatric EHR Working Group 2018