Prof. Mark Little and researchers from Trinity College Dublin have answered the HRB COVID-19 pandemic rapid response funding call. The Renal Inflammation Group are working on a COVID-19 project called DeCOmPRESS, which stands for ‘defining the disease course and immune profile of COVID-19 in the immunosuppressed patient’. Our team want to better understand how the immune system responds to the SARS-COV-2 virus and in patients who are taking immunosuppressive medications. This will help us provide clear guidance to patients with respect to cocooning and their current use of immunosuppressant medication. Watch this short video from Prof. Little explaining the study.

ANCA-vasculitis patients currently enrolled in the RKD Biobank are eligible for DeCOmPRESS. Patients will be split into different groups based on the treatment they have received for AAV and their responses to COVID-19 will be compared. The study process can be summarised in the figure below. If you have contracted COVID-19 please contact Please continue to follow government guidelines on social distancing and advice on protecting those most at risk. Visit our COVID-19 guidance page for vasculitis-specific advice.

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Prof Mark Little


If you have any questions about the study or you are interested in participating please contact

Study Contact Details


Role Name Address
Chief Investigator Prof Mark Little Trinity Health Kidney Centre, Tallaght University Hospital, Tallaght, Dublin 24
Co-Applicants Dr Lina Zgaga Department of Public Health and Primary Care, Trinity College Dublin
  Dr. Michelle O'Shaughnessy Department of Renal Medicine, Cork University Hospital
Project Manager Ms. Emma Leacy Trinity Translational Medicine Institute, St. James Hospital Dublin 8
Biobank Coordinator Dr. Alan Kennedy Trinity Translational Medicine Institute, St. James Hospital Dublin 8

Local Study Site Managers


Clinical Site Key Contact Clinical Role
Tallaght University Hospital Prof Mark Little Consultant Nephrologist
St. Vincent's University Hospital Prof Eamonn Molloy Consultant Rheumatologist
St. James’s Hospital Dr Niall Conlon Consultant Immunologist
Beaumont Hospital Prof Mark Little Consultant Nephrologist
Galway University Hospital Prof Matt Griffin Professor of Transplant Immunology
Cork University Hospital

Dr Michelle O’Shaughnessy

Dr Michael Clarkson

Consultant Nephrologist

Consultant Nephrologist