Research Impact Case Stories
Towards a kinder yet impactful way to conduct lung cancer research
Dr Dania Movia champions the reduction and replacement of animal testing via research and training of young scientists.
Improving education for GPs regarding Adolescent Mental Health
Youth suicide rates in Ireland are above the European average, and research has highlighted that there has been a notable increase in anxiety and depression among young people in Ireland over the past 10 years.
Supportive relationships between patients and family caregivers for decision-making in palliative care
Dr Geraldine Foley’s research is focused on investigating dimensions of mutual support between patients and family caregivers in palliative care, and on developing a framework for decision-making in palliative care.
Better adjuvants for paediatric vaccines
In their first year, children receive vaccinations against dangerous infections but achieve protection only after several booster vaccinations.
Social prescribing to improve adolescents’ wellbeing
Dr Margaret Lawler’s research focuses on understanding the role of psychosocial factors in adolescents’ body image and physical activity participation.
Listening to the voices of young people with disability experience
Life experiences particularly in late childhood and adolescence can impact on how young people see themselves in relation to their peers.
Multimodal Intervention for Depression Prevention in Older People
A large body of Dr Robert Briggs’s work has focused on advancing the understand of the mechanistic pathways underpinning late life depression, especially the link with cardiovascular disease and neurocardiovascular instability.
The Trinity International Development Initiative Impact Report 2008-2011
The Trinity International Development Initiative (TIDI) is the hub of international development at Trinity College. The initiative is currently funded by Irish Aid and the Higher Education Authority (HEA) under the Programme of Strategic Cooperation between Irish Aid and Higher Education and Research Institutes 2007‐2011.
The Trinity International Development Initiative Impact Report 2008-2011
The Trinity International Development Initiative (TIDI) is the hub of international development at Trinity College. The initiative is currently funded by Irish Aid and the Higher Education Authority (HEA) under the Programme of Strategic Cooperation between Irish Aid and Higher Education and Research Institutes 2007‐2011.
The KARMA-Dep-2 trial: Ketamine as a treatment for major depression
Researchers from the Department of Psychiatry at Trinity College Dublin are trialling a potential additional treatment for depression: the anaesthetic ketamine. Ketamine works differently from current antidepressants, although we are still finding out how.
Tripartite alliance to battle COVID-19
Researchers at St James’s Hospital, Tallaght University Hospital and Trinity College Dublin have received €7.5 million funding under Science Foundation Ireland’s Strategic Partnership Programme to accelerate research into understanding SARS-CoV2 and to develop solutions to inform pandemic responsiveness and protect our communities.
A new method of measuring satiety in clinical trials of hyperphagia and obesity
Prader-Willi Syndrome (PWS) is associated with impaired satiety control: not knowing when you have had enough to eat. Symptoms include hyperphagia (over-eating) and extreme obesity.
A ‘one-stop’ health surveillance clinic for children with Down Syndrome
Down syndrome (or Trisomy 21) is the most common chromosomal abnormality, making up 8% of all such cases registered Europe-wide.
Better ways to tell our story
At the heart of this research strategy 2021-2026 is a passion to better tell our story so that the School of Medicine and its outstanding research teams will gain the recognition and support they deserve.
Pioneering international research into transforming health systems
Catastrophic events over the last decade or so have highlighted the challenge of governing health systems at times of shock.
Pushing boundaries on Alzheimer’s detection, prevention, cure and care
Alzheimer’s disease (AD), the most common cause of dementia, occurs when toxic proteins accumulate in the brain, resulting in memory loss and impaired daily functioning.
Research on ageing: From research to practice to policy
Falls are very common as people get older and many result in hospitalisations.
The Irish childhood national diabetes register
Childhood Type 1 diabetes is potentially fatal. Poor disease control can cause life limiting complications in childhood and adult life, including blindness, kidney failure and amputations.
Gene therapy for haemophilia offers a potential cure
Haemophilia is a group of inherited disorders in which blood fails to clot properly, causing longer-than-normal bleeding.
Exercise is key following a cancer diagnosis
The National Cancer Registry of Ireland reports an overall improvement in cancer survival.
Energy to burn – how immune cells respond to infection during TB disease
Tuberculosis (TB) is the most deadly infectious disease globally.
Cellular biomarkers of disease onset, progression and response to treatment for rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease which causes inflammation, pain, swelling and stiffness in the joints.
Cancer immunotherapy as a first-line treatment
Oesophageal cancer cases exceeded 600,000 in 2020, with over half a million deaths, making it the 6th leading cause of cancer-related mortality worldwide.
An innovative method for detecting frailty
Frailty is related to getting older. It describes reserves, leaving us vulnerable to sudden changes in health triggered by seemingly small events such as a minor infection or a change in medication or environment.
The best model of human disease is the human
Neurodegenerative diseases are debilitating incurable conditions that cause decline in movement, thinking and behaviour.
Preventing Disease - Shining a new light on understanding the relationship between vitamin D and health
Vitamin D deficiency has been suggested as a risk factor for ~200 diseases. The suspected disease links have earned vitamin D a lot of attention; however, the absence of a definite proof has been fuelling a heated debate on whether these associations are direct and causal.
Re-balancing the immune system
The events of the past year have made us all too familiar with the lexicon of immunology and has highlighted the critical importance of our immune system in fighting infection. However, in some individuals genetic and environmental factors conspire to cause the immune system itself to attack their own bodies, resulting in inflammatory diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis.
Tackling Health Inequalities - Preventing cancer in disadvantaged women smokers
Smoking-related lung cancer is now the leading cause of cancer death in Irish women, having overtaken breast cancer. The incidence of new cases is the highest in Europe. The highest rates of smoking are among socio-economically disadvantaged women, who are more likely to smoke to cope with negative emotions and stressful situations, and experience more difficulties in quitting and are more likely to relapse.
State of the Art Therapies - Enabling translational nanomedicine and nanoMedical technology to overcome the valley of death in innovation
The valley of death in innovation is when the “idea” is not reaching sufficient scientific and financial support to make it into advanced clinical investigation or trials. The global success in the COVID-19 nanovaccine came about thanks to decades of nanotechnology-enabled drug development in cancer nanomedicine.