Genome Information

Title Authors Publication Spec
Psychiatric genetics: what's new in 2015? Corvin A, O'Donovan MC Lancet Psychiatry, 2016 A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders.
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Schizophrenia Working Group of the Psychiatric Genomics Consortium Nature, 2014 In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings.
De novo mutations in schizophrenia implicate chromatin remodelling and support genetic overlap with ASD and ID McCarthy et al. Molecular Psychiatry, 2014 In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.
An inherited duplication at the gene P21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis Morris DW et al. Human Molecular Genetics, 2014 We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders Kenny EM, et al. Molecular Psychiatry, 2014 In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data.
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia Irish Schizophrenia Genomics Consortium & WTCCC2 Biological Psychiatry, 2012 In a GWAS study of our cohort we provided further evidence for the role of MHC class I molecules in schizophrenia etiology.
Molecular pathways involved in neuronal cell adhesion and membrane scoffolding contribute to schizophrenia and bipolar disorder susceptibility O'Dushlaine C, et al. Molecular Psychiatry, 2011  
Common polygenic variation contributes to risk in schizophrenia and bipolar disorder O'Dushlaine C, et al. Nature, 2009  
Rare chromosomal deletions and duplications increase risk of schizophrenia International Schizophrenia Consortium Nature, 2008