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| Course Title | Molecular Medicine (P.Grad.Dip) |
| Qualification | Postgraduate Diploma |
| Duration | One Year Full-time / Two Years Part-time |
| Closing Date | 30th June annually |
| Next Intake | September annually |
Molecular Medicine is set to play an increasingly important role in the practice of medicine and research in the biological, medical and pharmaceutical/life science arenas and this will have broad ramifications on society and the economy. These require significant infrastructural capacity, key among these being trained personnel. Individuals conversant with key developments in Molecular Medicine will be required in the clinical, research and industrial arenas. Biotech companies need a cadre of individuals trained to the highest degree in the life sciences at all levels of management. So too will individuals who wish to undertake entrepreneurial business developments. The issue of adequate training of personnel in science is a national concern that our programmes in Molecular Medicine
seek to address.
Like the MSc this can be held over a one year full time or two year part time basis. The Diploma offers a comprehensive and contemporary overview of the area, given by experts in their fields and provides students with the knowledge to evaluate the literature and perform independent research.
The postgraduate Diploma has the same high standards of the MSc. but does not require a commitment of three months full time laboratory work. This makes it ideal for candidates in established careers with limited available time.
In order to ensure maximum flexibility and to accommodate candidates from different disciplines, the course is being offered in a 1 year format from the end of September to the beginning of July. The majority of lectures are given on Wednesdays and Thursdays of each week and occasionally on other days.
Term 1:
- Diploma students can choose modules from an intensive lecture timetable schedule which will take place all day on Wednesday's and Thursdays. There may be additional lectures on Fridays and Mondays throughout the term
- It will also include an optional week-long practical course (Molecular Biology) normally run in November
- Exams will be held in the final week of term
Term 2:
- This term continues with a significent lecture schedule
- It will also include an optional week long practical course(Cell Biology) normally run in February
- Exams held in final week of term
- Each candidate will work on a literature review in an areas of Molecular Medicine to be submitted in June of every year.
This Molecular Medicine course sets out to provide the applicant with a thorough understanding of:
- The human genome at a molecular level
- The integration of molecular and cellular biology in relation to human diseases
- The molecular basis of human genetic disease
- The molecular interactions between microbiological pathogens and the human host
- The technology currently employed in molecular genetics and cell biology
- The interaction between such technology and current clinical practice
- The molecular basis of common human malignancies
- The utilisation of knowledge on the molecular basis of human disease in planning and design of novel therapies, using phamacological agents or gene therapy
- The ethical and legal aspects of molecular medicine as it impinges on clinical practice
- A working appreciation of molecular and cellular biology at the practical level and development of the ability to perform independent research
- The ability to apply bioinformatic and computational techniques in medical and biological research, and information retrieval
On completion of the course, each candidate will have a considerable knowledge and understanding of the above topics and will have critically reviewed the current relevant literature with the submission of a literature review.
The programme is made up of two components:
- Taught Modules (55 ECTS)
- Research Skills Module (15 ECTS)
The candidate will be introduced, initially at a basic level, to technical skills in molecular and cell biology through selecting subjects from the core and advanced module options. Core modules will cover concepts involved in both cellular and molecular biology and also an introduction to the understanding of the applications of bioinformatics in this area.
| Module 1 - CBCSM - Cellular Biology & Cell Signalling Mechanisms |
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| Aim: The aim of this module is to give the student a broad overview of the structure and function of the mammalian cell and its organelles. It then explores the molecular basis for cellular mechanisms such as the cell cycle and the apoptotic process. Study of the cytoskeleton and associated proteins will allow an understanding of cell division and migration. The module then aims to describe the basic mechanisms of cell cell communication and intracellular signalling processes. The approach is to teach the mechanisms by which cells transmit extracellular signals from the surface receptors to the nucleus resulting in changes in gene expression. Having completed this module, students will be competent to expand their basic knowledge in cell biology, understand the current literature in the area and will be in a position to study the cellular and molecular basis of normal and pathogenic cellular processes. |
| Module 2 - Introduction to Genetics and Development - IGD |
| Aim: This module consists of Introductory modules on basic processes in genetics as well as a short module on the genetics and cellular biology of development, an excellent system for the study of fundamental processes. Thus this will give coverage to the basic ideas of DNA replication, mutation and repair and the transcription and translation of the information encoded in the DNA into mRNA and protein. It has become increasingly clear that these are highly complex processes subject to tiers of regulatory intervention and some of the more recent discoveries relating to regulation of these processes, for example by microRNAs means will be discussed. The short course on developmental biology covers issues of cell fate and familiarises candidates with the fundamentals of stem cell biology. |
| Module 3 - Molecular Oncology - MO |
| This module is a specialised or advanced module dealing with the subject of molecular oncology from a variety of perspectives. The basics components of carcinogenesis such as tumour suppressor genes and oncogenes are discussed as are the contributions of important mechanisms such as inflammation and environmental exposures. However more and more is known about the altered genomics of cancer cells and aberrations of normal cellular processes such signal transduction, and it is also becoming clear that while many events are frequently observed in different types of cancer, most if not all cancers have molecular events and programmes that are unique to each type. Thus this module also includes lectures that focus on important types of cancer, describing the molecular events known to contribute to the carcinogenic state. |
| Module 4 Human Genetics - HG |
| This module consists of two components, one an introduction to Human molecular genetics and the other covering evolution and selection which is a basic tenet of modern biology with ramifications is all aspects of life sciences. The combined course will cover the basic elements of human population genetics from a molecular point of view. Many of the principles underlying the recent coming of age of disease genetics are discussed such as linkage and association genetic mapping, basic structure and genetics of populations, and the genetics of complex diseases. In the second component of the module, we discuss the evolution of the human race and molecular evolution of viruses for example HIV. This is essential to understand the structure of human populations around the globe and particular disease associations, while the molecular evolution of viruses and other pathogens is of central significance to global health. |
| Module 5 - Molecular and Cellular Immunology - MCI |
| This module provides an oversight of the processes which mediate the immune system’s response to pathogens. Thus it delves into the molecular mechanisms underlying the innate and adaptive immune responses, including the roles of B cells and Tcells including recent advances into understanding the activities of specialised lineages of T cells. In depth coverage of intra and inter-cellular signalling are included. Intrinsic to the immune response is the inflammatory response which plays such a critical role in human disease including degenerative diseases and autoimmune conditions. |
| Module 6 - Infectious Agents, Biology & Clinical Implications - IABCI |
| A central theme in the interactions of modern health science is to better understand the modes of interaction of micro-organisms and the host. It has become clear in recent years that these interactions are highly specific and allow the micro-organism to manipulate its environment using molecular strategies. Equally the host has developed means of containing and eliminating organisms, many of which appear to be variable at a genetic level. The aim of this module is to investigate what is known regarding the specific mechanisms by which these interactions occur and the key elements of the biology of major pathogenic organisms. It includes introductory lectures giving an overview of the area and important topics in current research and specific lectures covering , viral, bacterial and parasitic infections such as malaria. |
| Module 7 and 8 - Molecular Mechanisms of Human Disease |
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Molecular Mechanisms of Human Disease I - MMHD1 Molecular Mechanisms of Human Disease II - MMHD2 |
| Module 9 - Advanced Diagnostics and Therapeutics - ADT |
| This module offers a range of lectures covering novel applications of molecular technologies in the diagnostic arena as well as investigating the therapeutic developments made possible by increasing understanding of biology at the molecular level. Thus topics include molecular diagnostics in applications such as cancer and infectious diseases as well as cellular and molecular therapeutics including molecular drug targets, vaccines and drug design and delivery. |
| Module 10 - Precision and Translational Nanomedicine - PTN |
| This module explores and expands on clinically approved nanotechnology-enabled medicines and the new generation of medicinal nano-products under the translational pathway for precision drug targeting. Many of these in fact are based on advanced nanobiomaterials offering opportunities for their use in diagnosis, treatment, combination or multifunctional applications. Precision and Translational Nanomedicine approaches are presented by a highly interdisciplinary team of physicists, chemists, engineers, biologists and medics who are actively involved in developing this field as world leading scientists. |
This is a mandatory module that constitutes 15 ECTS and incorporates the components listed below. This runs throughout the year.
- Bioinformatics BIO (9 hours)
The following areas will be covered from a theoretical and “hands on” approach.
- Bioinformatics and Molecular Medicine- What’s Out There?
- Introduction to Databases and Sequences Software.
- Sequence Retrieval Software.
- Homology Searching.
- Genome Research
This course will be delivered at the beginning of Term 3
- Ethical Issues and Clinical Research EICR
Ethical and legal considerations are fundamental to the developing field of Molecular Medicine. In this module we will investigate these concepts drawing on the experience gained internationally. - Statistics Course:
This introduction to practical data analysis is designed for those requiring the skills to analyse and interpret experimental data as part of their everyday research. The course introduces participants to statistical principles through a set of lectures, supplemented throughout with examples and guided practical exercises. The two-day course will take place in term 1. - Research Skills Seminars RSS
These seminars in Molecular and Cellular Biology Research Skills will take place in terms 1 and 2, and will in the main be given in conjunction with the practical courses. - Business and Industry Seminars:
A series of speakers will be invited to discuss employment and vocational prospects with students. This will take place on one or more evenings in Terms 2 and 3. All students should attend. - Literature Review:
Each student will be required to write a literature review on an important area of Molecular Medicine. - Journal Clubs:
Journal clubs will be hosted throughout terms 1 & 2.
Prof. Ross McManus is Professor of Molecular Medicine. He is Director of the Molecular Medicine Postgraduate Education Programme since 2003. His research interests are in the genetics of complex diseases with an inflammatory component such as coeliac disease, arthropathies and sepsis and has been involved in several major national and international collaborative investigations into these diseases. He is a member of the Eurolife Educational Alliance, comprising Trinity and seven other leading European universities, promoting leadership in postgraduate education and student exchanges across Europe and developing a common doctoral training programme within the Eurolife network. He is also a member of the Molecular Medicine Ireland education committee.
Dr. Henry Windle is a lecturer in the Department of Clinical Medicine, TCD. He coordinates the IABCI module in the MSc in Molecular Medicine and also coordinates the M.Sc. in Biomedical Sciences programme for Intercalated medical students. His research interests include bacterial-host interaction in relation to the gastric-cancer associated pathogen Helicobacter pylori and the colon-cancer associated organism, Fusobacterium nucleatum.
Professor Aideen Long is a Principal Investigator in the Trinity Translational Medicine Institute, based on the St James’s Hospital campus. Her research focuses on the signalling aspects of leukocyte-endothelial cell interaction and the elucidation of mechanisms used by lymphocytes to circulate from the bloodstream into tissue. The processes of leukocyte extravasation and tumour cell metastasis share many common mechanisms. Her research group is particularly interested in the regulation of cytoskeletal shape during the migratory process and the structural proteins and enzymes that regulate this. This research is important in the context of elucidating the mechanisms of inflammatory and autoimmune diseases such as inflammatory bowel disease and multiple sclerosis. At a translational level the group has studied mechanisms used by the Hepatitis C virus to subvert the immune system. In addition they have investigated the cellular response to bile acids in models of oesophageal and colonic cancer.
Dr. Shigeki Nakagome received his Ph.D. at The University of Tokyo in 2010 with the focus on the evolutionary pressures on alleles associated with Crohn's disease. As a postdoctoral researcher, He first joined The Institute of Statistical Mathematics from 2011 to 2014 where he developed a new statistical method, kernel Approximate Bayesian Computation. He obtained further postdoctoral training at University of Chicago from 2013 to 2016. During this training, he has acquired expertise in population and functional genomics to develop statistical approaches for understanding selective pressures on immunity genes and to connect genetic polymorphisms to their functional consequences in the immune system. Since 2016, he has worked as Ussher Assistant Professor in Genomic Medicine at School of Medicine, Trinity College Dublin.
Dr. Patrick Walsh received his PhD in biochemistry at UCC in 2001. In 2011, he joined the NCRC as a lecturer in Paediatric Immunology and Principal Investigator on the Paediatric Research in Translational Immunology (PRiTI) programme, which coincided with his receipt of a Science Foundation Ireland President of Ireland Young Researcher award in 2011.The research conducted by Prof. Walsh’s group investigates the mechanisms which control immunity and tolerance, particularly in the context of autoimmune and inflammatory disease conditions. They take a translational research approach, using both preclinical models, and patient samples, to investigate novel mechanisms implicated in the pathogenesis of diseases such as psoriasis and inflammatory bowel disease, with the goal of identifying novel targets for therapeutic intervention. His aim is to translate his groups findings towards the development of improved therapeutics for autoimmune and inflammatory disease in patients. He also coordinates the MCI module in the MSc in Molecular Medicine.
Dr. Dr. Adriele Prina-Mello, PhD, is an Ussher Assistant Professor in Translational Nanomedicine, Department of Clinical Medicine at the Trinity Translational Medicine Institute, School of Medicine.Prina-Mello's research interests are focused on the translation of nanotechnology-enabled products (e.g., medical device, medicinal drugs, hybrid products such as theranostics); advanced materials and their multifunctional solutions; device and instrumentation applications into the medical research area as Nanomedicine tools with the potential to become next generation medical standards or standards of care.Prina-Mello is extensively involved in many Pan-European Networks, Cost Actions, and European Commission projects. He is also an active member at TCD on several fronts: School of Medicine Research Committee, Trinity Cancer committee, AMBER/CRANN industry-driven platform, the TTMI Radiobiology group, TTMI outreach committee. He also coordinates the Precision and Translational Nanomedicine (PTN) module in the MSc in Molecular Medicine.
Eligibility
Applicants should have a primary degree in Biology, Medicine, Dentistry, Veterinary or Pharmaceutical Sciences. Applicants with other scientific qualifications may also be considered. Those with a science degree must have achieved at least a II-1 honours degree or equivalent.
We welcome students from all over the world, but note that visa applications for those coming from outside the EU may be lengthy, and we encourage these applicants to apply early, where possible.
Application Procedure
Application for this course is online: https://www.tcd.ie/courses/postgraduate/courses/molecular-medicine-pgraddip/
Fees
Up-to-date information about fees can be found on the Academic Registry website: https://www.tcd.ie/academicregistry/fees-payments/course-fees/
For more information about admissions, please contact Ana Llavori: T: +353 1 896 3157 / E: molec.medic@tcd.ie
The programme is based in the Trinity Translational Medicine Institute at the Trinity Centre for Health Sciences, on the St. James’s Hospital Campus. St. James’s is the biggest hospital in Ireland, and is an academic teaching hospital linked with Trinity College Dublin as part of the Trinity Health Ireland group.
Executive Officer
Ana Llavori
T: +353 1 896 3157
E: molec.medic@tcd.ie
Postal Address: Room 1.15, Discipline of Clinical Medicine, Trinity Centre for Health Sciences, James's Street, Dublin D08 W9RT, Ireland.