Professor Johannes Wagener

Professor Johannes Wagener

Associate Professor Consultant, Clinical Microbiology

3531896 2138

Publications and Further Research Outputs

  • Aspergillus in, Medizinische Mikrobiologie und Infektiologie, 2020, [Johannes Wagener, Oliver Kurzai]Book Chapter, 2020, DOI , URL
  • Basch M, Wagner M, Rolland S, Carbonell A, Zeng R, Khosravi S, Schmidt A, Aftab W, Imhof A, Wagener J, Conradt B, Wagener N., Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates., Molecular biology of the cell, 31, (8), 2020, p753-767Journal Article, 2020, DOI
  • Schroeder I, Dichtl K, Liebchen U, Wagener J, Irlbeck M, Zoller M, Scharf C., Digestive enzymes of fungal origin as a relevant cause of false positive Aspergillus antigen testing in intensive care unit patients., Infection, 49, (2), 2021, p241-248Journal Article, 2021, DOI
  • Dichtl K, Koeppel MB, Wallner CP, Marx T, Wagener J, Ney L., Food poisoning: an underestimated cause of Boerhaave syndrome., Infection, 48, (1), 2020, p125-128Journal Article, 2020, DOI
  • alpha- and beta-1,3-Glucan Synthesis and Remodeling. in, editor(s)Jean-Paul Latgé , The Fungal Cell Wall: An Armour and a Weapon for Human Fungal Pathogens, Springer International Publishing, 2020, pp53-82 , [Wagener J, Striegler K, Wagener N.]Book Chapter, 2020, DOI
  • Sturm L, Geißel B, Martin R, Wagener J., Differentially Regulated Transcription Factors and ABC Transporters in a Mitochondrial Dynamics Mutant Can Alter Azole Susceptibility of Aspergillus fumigatus., Frontiers in microbiology, 11, 2020, p1017Journal Article, 2020, DOI
  • Dichtl K, Forster J, Ormanns S, Horns H, Suerbaum S, Seybold U, Wagener J., Comparison of ß-D-Glucan and Galactomannan in Serum for Detection of Invasive Aspergillosis: Retrospective Analysis with Focus on Early Diagnosis., Journal of fungi (Basel, Switzerland), 6, (4), 2020Journal Article, 2020, DOI
  • Steger M, Bermejo-Jambrina M, Yordanov T, Wagener J, Brakhage AA, Pittl V, Huber LA, Haas H, Lass-Flörl C, Posch W, Wilflingseder D., ß-1,3-glucan-lacking Aspergillus fumigatus mediates an efficient antifungal immune response by activating complement and dendritic cells., Virulence, 10, (1), 2019, p957-969Journal Article, 2019, DOI
  • Dichtl K, Seybold U, Ormanns S, Horns H, Wagener J., Evaluation of a Novel Aspergillus Antigen Enzyme-Linked Immunosorbent Assay., Journal of clinical microbiology, 57, (7), 2019Journal Article, 2019, DOI
  • von Lilienfeld-Toal M, Wagener J, Einsele H, Cornely OA, Kurzai O., Invasive Fungal Infection., Deutsches Arzteblatt international, 116, (16), 2019, p271-278Journal Article, 2019, DOI
  • Dichtl K, Seybold U, Wagener J., Evaluation of a Turbidimetric ß-d-Glucan Test for Detection of Pneumocystis jirovecii Pneumonia., Journal of clinical microbiology, 56, (7), 2018Journal Article, 2018, DOI
  • Ruf D, Brantl V, Wagener J., Mitochondrial Fragmentation in Aspergillus fumigatus as Early Marker of Granulocyte Killing Activity., Frontiers in cellular and infection microbiology, 8, 2018, p128Journal Article, 2018, DOI
  • Geißel B, Loiko V, Klugherz I, Zhu Z, Wagener N, Kurzai O, van den Hondel CAMJJ, Wagener J., Azole-induced cell wall carbohydrate patches kill Aspergillus fumigatus., Nature communications, 9, (1), 2018, p3098Journal Article, 2018, DOI
  • Loiko V, Wagener J., The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on Recovery of the ß-1,3-Glucan Synthase Fks1., Antimicrobial agents and chemotherapy, 61, (2), 2017Journal Article, 2017, DOI
  • Geißel B, Penka M, Neubauer M, Wagener J., The ER-mitochondria encounter structure contributes to hyphal growth, mitochondrial morphology and virulence of the pathogenic mold Aspergillus fumigatus., International journal of medical microbiology : IJMM, 307, (1), 2017, p37-43Journal Article, 2017, DOI
  • Leonhardt Y, Kakoschke SC, Wagener J, Ebel F., Lah is a transmembrane protein and requires Spa10 for stable positioning of Woronin bodies at the septal pore of Aspergillus fumigatus., Scientific reports, 7, 2017, p44179Journal Article, 2017, DOI
  • Wagener J, Loiko V., Recent Insights into the Paradoxical Effect of Echinocandins., Journal of fungi (Basel, Switzerland), 4, (1), 2017Journal Article, 2017, DOI
  • Dichtl K, Samantaray S, Wagener J., Cell wall integrity signalling in human pathogenic fungi., Cellular microbiology, 18, (9), 2016, p1228-1238Journal Article, 2016, DOI
  • Dichtl K, Wagener J, Tschöp J, Ney L., Analysis of peritoneal galactomannan for the diagnosis of Aspergillus peritonitis., Infection, 44, (5), 2016, p683-686Journal Article, 2016, DOI
  • Kotz A, Wagener J, Engel J, Routier F, Echtenacher B, Pich A, Rohde M, Hoffmann P, Heesemann J, Ebel F., The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity., Fungal genetics and biology : FG & B, 47, (2), 2010, p169-178Journal Article, 2010, DOI
  • Dichtl K, Ebel F, Dirr F, Routier FH, Heesemann J, Wagener J., Farnesol misplaces tip-localized Rho proteins and inhibits cell wall integrity signalling in Aspergillus fumigatus., Molecular microbiology, 76, (5), 2010, p1191-1204Journal Article, 2010, DOI
  • Wagener J, Spjuth O, Willighagen EL, Wikberg JE., XMPP for cloud computing in bioinformatics supporting discovery and invocation of asynchronous web services., BMC Bioinformatics, 10, 2009, p279Journal Article, 2009, DOI
  • Spjuth O, Alvarsson J, Berg A, Eklund M, Kuhn S, Mäsak C, Torrance G, Wagener J, Willighagen EL, Steinbeck C, Wikberg JE., Bioclipse 2: a scriptable integration platform for the life sciences., BMC Bioinformatics, 10, 2009, p397Journal Article, 2009, DOI
  • Wagener J, Echtenacher B, Rohde M, Kotz A, Krappmann S, Heesemann J, Ebel F., The putative alpha-1,2-mannosyltransferase AfMnt1 of the opportunistic fungal pathogen Aspergillus fumigatus is required for cell wall stability and full virulence., Eukaryotic cell, 7, (10), 2008, p1661-1673Journal Article, 2008, DOI
  • Spjuth O, Helmus T, Willighagen EL, Kuhn S, Eklund M, Wagener J, Murray-Rust P, Steinbeck C, Wikberg JE., Bioclipse: an open source workbench for chemo- and bioinformatics., BMC Bioinformatics, 8, 2007, p59Journal Article, 2007, DOI
  • Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS., OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria., Molecular biology of the cell, 18, (9), 2007, p3582-3590Journal Article, 2007, DOI
  • Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS., Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology., The Journal of biological chemistry, 281, (49), 2006, p37972-37979Journal Article, 2006, DOI
  • Götz R, Panzer S, Trinks N, Eilts J, Wagener J, Turrà D, Di Pietro A, Sauer M, Terpitz U., Expansion Microscopy for Cell Biology Analysis in Fungi., Frontiers in microbiology, 11, 2020, p574Journal Article, 2020, DOI
  • Dichtl K, Seybold U, Wagener J., Serological biomarkers of candidemia: a retrospective evaluation of three assays., Infection, 47, (2), 2019, p217-224Journal Article, 2019, DOI
  • Wagener J., Regulation of mitochondrial inner membrane fusion: divergent evolution with similar solutions?, Current genetics, 62, (2), 2016, p291-294Journal Article, 2016, DOI
  • Dichtl K, Samantaray S, Aimanianda V, Zhu Z, Prévost MC, Latgé JP, Ebel F, Wagener J., Aspergillus fumigatus devoid of cell wall ß-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors., Molecular microbiology, 95, (3), 2015, p458-471Journal Article, 2015, DOI
  • Neubauer M, Zhu Z, Penka M, Helmschrott C, Wagener N, Wagener J., Mitochondrial dynamics in the pathogenic mold Aspergillus fumigatus: therapeutic and evolutionary implications., Molecular microbiology, 98, (5), 2015, p930-945Journal Article, 2015, DOI
  • Samantaray S, Neubauer M, Helmschrott C, Wagener J., Role of the guanine nucleotide exchange factor Rom2 in cell wall integrity maintenance of Aspergillus fumigatus., Eukaryotic cell, 12, (2), 2013, p288-298Journal Article, 2013, DOI
  • Helmschrott C, Sasse A, Samantaray S, Krappmann S, Wagener J., Upgrading fungal gene expression on demand: improved systems for doxycycline-dependent silencing in Aspergillus fumigatus., Applied and environmental microbiology, 79, (5), 2013, p1751-1754Journal Article, 2013, DOI
  • Dichtl K, Helmschrott C, Dirr F, Wagener J., Deciphering cell wall integrity signalling in Aspergillus fumigatus: identification and functional characterization of cell wall stress sensors and relevant Rho GTPases., Molecular microbiology, 83, (3), 2012, p506-519Journal Article, 2012, DOI
  • Münchhoff M, Strube H, Wagener J, Bogner JR., [Clostridium-difficile-colitis: more frequent and more severe]., MMW Fortschritte der Medizin, 154, (17), 2012, p61-63Journal Article, 2012, DOI
  • Dirr F, Echtenacher B, Heesemann J, Hoffmann P, Ebel F, Wagener J., AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus., International journal of medical microbiology : IJMM, 300, (7), 2010, p496-502Journal Article, 2010, DOI
  • McCormick A, Heesemann L, Wagener J, Marcos V, Hartl D, Loeffler J, Heesemann J, Ebel F., NETs formed by human neutrophils inhibit growth of the pathogenic mold Aspergillus fumigatus., Microbes and infection, 12, (12-13), 2010, p928-936Journal Article, 2010, DOI
  • Kotz A, Wagener J, Engel J, Routier FH, Echtenacher B, Jacobsen I, Heesemann J, Ebel F., Approaching the secrets of N-glycosylation in Aspergillus fumigatus: characterization of the AfOch1 protein., PloS one, 5, (12), 2010, pe15729Journal Article, 2010, DOI
  • Rueping J, Klingenstein A, Wagener J, Kampik A, Kook D., [Iris tumor of unknown origin]., Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 110, (12), 2013, p1185-1187Journal Article, 2013, DOI
  • Seybold U, Wagener J, Jung J, Sammet S., Multidrug-resistant organisms among refugees in Germany: we need evidence-based care, not fear-based screening., The Journal of hospital infection, 92, (3), 2016, p229-231Journal Article, 2016, DOI
  • Wagener J, Seybold U., [MRSA - hygiene management, diagnostics and treatment]., Deutsche medizinische Wochenschrift (1946), 139, (13), 2014, p643-51; quiz 652-4Journal Article, 2014, DOI
  • Wagener J, Kurzai O, [Candida auris: Steckbrief eines neuen Pilzes], Deutsches Arzteblatt - SUPPLEMENT: Perspektiven der Infektiologie, 116, (4), 2019, p29-30Journal Article, 2019
  • Wagener J, Walther G, Kurzai O, [Antimykotikaresistenz bei klinisch relevanten Erregern invasiver Pilzinfektionen in Deutschland.], Der Mikrobiologe, 28, 2018, p13-18Journal Article, 2018
  • The septal cell wall of filamentous fungi in, editor(s)Héctor Manuel Mora-Montes , The Fungal Cell Wall, Nova Science Publishers, 2013, [Beck J, Wagener J, Ebel F]Book Chapter, 2013
  • Dunne MR, Wagener J, Loeffler J, Doherty DG, Rogers TR, Unconventional T cells - New players in antifungal immunity, Clinical Immunology, 2021, p108734-Journal Article, 2021, DOI , URL
  • Wagener J, Striegler K, Wagener N, "- and ß-1,3-Glucan Synthesis and Remodeling., Current topics in microbiology and immunology, 2020Journal Article, 2020, DOI
  • Krone M, Gütling J, Wagener J, Lâm TT, Schoen C, Vogel U, Stich A, Wedekink F, Wischhusen J, Kerkau T, Beyersdorf N, Klingler S, Backes S, Dölken L, Gasteiger G, Kurzai O, Schubert-Unkmeir A., Performance of Three SARS-CoV-2 Immunoassays, Three Rapid Lateral Flow Tests, and a Novel Bead-Based Affinity Surrogate Test for the Detection of SARS-CoV-2 Antibodies in Human Serum., Journal of clinical microbiology, 59, (8), 2021, pe0031921Journal Article, 2021, DOI
  • Dichtl K, Koc Ö, Forster J, Scharf C, Suerbaum S, Andrassy J, Wagener J, Schroeder I., An invasive infection caused by the thermophilic mold Talaromyces thermophilus., Infection, 49, (6), 2021, p1347-1353Journal Article, 2021, DOI
  • Brantl V, Boysen JM, Yap A, Golubtsov E, Ruf D, Heinekamp T, Straßburger M, Dichtl K, Haas H, Hillmann F, Wagener J., Peroxiredoxin Asp f3 Is Essential for Aspergillus fumigatus To Overcome Iron Limitation during Infection., mBio, 12, (4), 2021, pe0097621Journal Article, 2021, DOI
  • Schub T, Forster J, Suerbaum S, Wagener J, Dichtl K., Comparison of a Lateral Flow Assay and a Latex Agglutination Test for the Diagnosis of Cryptococcus Neoformans Infection., Current microbiology, 78, (11), 2021, p3989-3995Journal Article, 2021, DOI
  • Forster J, Koc Ö, Koeppel MB, Hamprecht A, Kurzai O, Suerbaum S, Wagener J, Dichtl K., ß-1,3-D-glucan and galactomannan as biomarkers for the detection of invasive Geotrichum and Magnusiomyces infections: a retrospective evaluation., Journal of clinical microbiology, 2021, pJCM0160721Journal Article, 2021, DOI
  • Forster J, Dichtl K, Wagener J., Lower beta-1,3-D-glucan testing cut-offs increase sensitivity for non-albicans Candida species blood stream infections., Mycoses, 2022Journal Article, 2022, DOI
  • Forster J, Hoenigl M, Suerbaum S, Wagener J, Dichtl K., Serologic biomarkers in Candida and Aspergillus infections of the central nervous system: A comparison of galactomannan, mannan and ß-1,3-D-gucan testing from serum and cerebrospinal fluid., Mycoses, 65, (7), 2022, p709-714Journal Article, 2022, DOI
  • Koc Ö, Kessler HH, Hoenigl M, Wagener J, Suerbaum S, Schubert S, Dichtl K., Performance of Multiplex PCR and ß-1,3-D-Glucan Testing for the Diagnosis of Candidemia., Journal of fungi (Basel, Switzerland), 8, (9), 2022, p972Journal Article, 2022, DOI
  • Dichtl K, Osterman A, Barry R, Wagener J., A novel microarray-based PCR assay for the detection of HSV-1, HSV-2, and VZV skin infections: A retrospective analysis., Journal of virological methods, 312, 2023, p114650Journal Article, 2023, DOI
  • Dichtl K, Barry R, Angstwurm MWA, Suerbaum S, Wagener J., Performance of galactomannan testing from endotracheal aspirate to guide bronchoalveolar lavage in the diagnosis of invasive aspergillosis., Infection, 2023Journal Article, 2023, DOI
  • Baldin C, Kühbacher A, Merschak P, Wagener J, Gsaller F., Modular Inducible Multigene Expression System for Filamentous Fungi., Microbiology spectrum, 10, (6), 2022, pe0367022Journal Article, 2022, DOI
  • Liebl M, Huber L, Elsaman H, Merschak P, Wagener J, Gsaller F, Müller C., Quantifying Isoprenoids in the Ergosterol Biosynthesis by Gas Chromatography-Mass Spectrometry., Journal of fungi (Basel, Switzerland), 9, (7), 2023, p768Journal Article, 2023, DOI
  • Mok S, Roycroft E, Flanagan PR, Wagener J, Fitzgibbon MM., Investigation of genomic mutations and their association with phenotypic resistance to new and repurposed drugs in Mycobacterium tuberculosis complex clinical isolates., The Journal of antimicrobial chemotherapy, 2023, pdkad252Journal Article, 2023, DOI

Research Expertise

  • Title
    Cell wall stress response in Aspergillus fumigatus: molecular characterization of the signal transduction pathways
    Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194178034,
    Funding Agency
    DFG, German Research Foundation
    Date From
    Date To
  • Title
    Investigation of the role of trace elements in standardized antifungal susceptibility testing
    Funding Agency
    Pfizer Healthcare Ireland
    Date From
    Date To
  • Title
    Resist or die: Identification and functional characterization of cell wall integrity determinants important for the survival of Aspergillus fumigatus challenged by neutrophil granulocytes
    Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 430055013,
    Funding Agency
    DFG, German Research Foundation
    Date From
    Date To
  • Title
    Molecular characterization of mitochondrial fission and fusion mechanisms in Aspergillus fumigatus and their roles in pathogenicity, viability and stress tolerance
    Deutsche Forschungsgemeinschaft (DFG) - Project number 249764016,
    Funding Agency
    DFG, German Research Foundation
    Date From
    Date To


  • Forschungsförderpreis of the German-speaking Mycological Society (Deutschsprachige Mykologische Gesellschaft, DMykG; ) 2018
  • Clausthal-Zellerfeld Award on proposal of the Robert Koch Foundation ( ) 2016
  • Becton Dickinson Research Award "Clinical Microbiology" of the German Society of Hygiene and Microbiology (DGHM; ) 2012
  • Young talent award of the specialized group "Eukaryotic Pathogens" of the German Society of Hygiene and Microbiology (DGHM) 2009
  • Bavarian Medical Association (BLÄK) 2020
  • Deutschsprachige Mykologische Gesellschaft (German-speaking Mycological Society; DMykG)
  • Irish Fungal Society (IFS)
  • Fellow of European Confederation of Medical Mycology
  • Fellow of the Faculty of Pathology (FFPath) of the Royal College of Physicians of Ireland (RCPI)
  • German Society of Hygiene and Microbiology (DGHM)
  • Irish Society of Clinical Microbiologists (ISCM)
  • Medical Council of Ireland
  • Secretary of the specialized group "Eukaryotic Pathogens" of the German Society of Hygiene and Microbiology (DGHM) Since 2022
  • Co-chairman of the specialized group "Eukaryotic Pathogens" of the German Society of Hygiene and Microbiology (DGHM) 2019 - 2022
  • Irish Representative on the Antifungal Susceptibility Testing (AFST) Subcommittee of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) Since 2022
  • Associate Editor for Frontiers in Microbiology Since 2018