Dr. Yvonne Langan

• Lynn E, Lyons S, Langan Y, Craig S, Doherty C, The role of alcohol dependency in deaths among people with epilepsy recorded by the National Drug-Related Deaths Index (NDRDI) in Ireland, 2004-2013, Seizure, 45, 2017, p52 - 55Journal Article, 2017, DOI , URL
• McNamara PH, Costelloe L, Langan Y, Redmond J., Anti-Yo positive dorsal root ganglionopathy, Journal of Neurology, 258, 2010, p1400 - 1401Journal Article, 2010, DOI
• McNamara PH, Costelloe L, Langan Y, Redmond J., Aquaporin-4 seropositivity in a patient with coeliac disease but normal neurological examination and imaging, Journal of Neurology, 258, 2011, p702 - 703Journal Article, 2011, DOI
• Iqbal M, Connolly S, Langan Y, Redmond J., A case of Lambert-Eaton myasthenic syndrome with possible myasthenia gravis, Irish Medical Journal, 105, 2012, p183 - 184Journal Article, 2012, URL
• O'Connor G, Bradley D, McNamara P, Connolly S, Langan Y, Redmond J., Late-onset CMT phenotype caused by a novel mutation in the MPZ gene, European Journal of Neurology, 19, 2012, p65 - 66Journal Article, 2012, DOI
• Chalissery AJ, Munteanu T, Langan Y, Brett F, Redmond J., Diverse phenotype of hypokalaemic periodic paralysis within a family, Practical Neurology, 18, (1), 2018, p60 - 65Journal Article, 2018, DOI
• McKenna MC, Al-Hinai M, Bradley D, Doran E, Hunt I, Hutchinson S, Langan Y, O'Rourke D, Qasem R, Redmond J, Troy E, Doherty CP., Patients' Experiences of Remote Neurology Consultations during the COVID-19 Pandemic, European Neurology, 83, (6), 2021, p622 - 625Journal Article, 2021, DOI
• Fearon C, Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J., Very-late-onset Friedreich's ataxia: Diagnosis in a kindred with late-onset cerebellar ataxia, Practical Neurology, 1, (20), 2020, p55 - 58Journal Article, 2020, DOI
• Langan Y, Nashef L, Sander JWAS, Case control study of SUDEP, Neurology, 64, (7), 2005, p1131 - 1133Journal Article, 2005, DOI
• Langan Y, Nashef L, Sander JWAS, Sudden unexpected death in epilepsy: a series of witnessed deaths., Journal of Neurology, Neurosurgery and Psychiatry, 68, (2), 2000, p211 - 213Journal Article, 2000, DOI
• Langan Y, Nashef L, Sander JWAS, Certification of deaths attributable to epilepsy, Journal of Neurology, Neurosurgery and Psychiatry, 73, (6), 2002, p751 - 752Journal Article, 2002, DOI
• Langan Y, Nolan M, Hutchinson M., The incidence of sudden unexpected death in South Dublin and Wicklow, Seizure, 7, (5), 1998, p355 - 358Journal Article, 1998, DOI
• Langan Y, Sander JWAS, Patients with epilepsy who die do not always have cardiac disease, Archives of Neurology, 56, (2), 1999, p249 - 249Journal Article, 1999, DOI
• Langan Y, Lucas R, Jewell H, Toublanc N, Schaefer H, Sander JW, Patsalos P., Talamapanel, a new antiepileptic drug: single and multiple does pharmacokinetics and initial one week experience in patients with chronic intractable epilepsy, Epilepsia, 44, (1), 2003, p46 - 53Journal Article, 2003, DOI
• Lamberts RJ, Thjis Rd, Laffan A., Langan Y, Sander JW, Sudden unexpected death in epilepsy:people with nocturnal seizures may be at highest risk, Epilepsia, 53, (2), 2012, p253 - 257Journal Article, 2012, DOI
• Hersdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A., ILAE Commission on Epidemiology; subcommission on mortality. Combined analysis of risk factors for SUDEP., Epilepsia, 52, (6), 2011, p1150 - 1159Journal Article, 2011, DOI
• Hersdorffer DC, Tomson T, Benn E, Sander JW, Nilsson L, Langan Y, Walczak TS, Beghi E, Brodie MJ, Hauser A., ILAE Commission on Epidemiology; subcommission on mortality. Do antiepileptic drugs or tonic clonic seizure frequency increase SUDEP risk?, Epilepsia, 53, (2), 2012, p249 - 252Journal Article, 2012, DOI
• Laffan A, Langan Y, Understanding EEG indications and reports: a survey of NCHDs, Irish Medical Journal, 106, (2), 2013, p59 - 60Journal Article, 2013, URL
• Al Bayati F, McGrane C, Sweeney A, Langan Y., The role of ambulatory EEG in the investigation of paroxysmal events, Irish Medical Journal, 114, (3), 2021, p304 - 304Journal Article, 2021
• Langan Y, Sander JWAS, Sudden unexpected death in epilepsy, CNS Drugs, 13, (5), 2000, p337 - 349Journal Article, 2000, URL
• Lhatoo SD, Langan Y, MacDonald BK, Zeidan S, Sander JW, Sudden unexpected death: a rare event in a large comminity based prospective cohort with newly diagnosed epilepsy and high remission rates., Journal of Neurology, Neurosurgery and Psychiatry, 66, (5), 1999, p692 - 693Journal Article, 1999, DOI
• Langan Y, Duncan JS, Sander JW., An audit of the perdeived efficacy and tolerability of gabapentin therapy in an outpatient cohort with chronic epilepsy, European Neurology, 41, (2), 1999, p111 - 113Journal Article, 1999, DOI
• Hennessy MJ, Langan Y, Elwes RDC, Binnie CD, Polkey CE, Nashef L., A study of mortality after temporal lobe epilepsy surgery, Neurology, 53, (6), 1999, p1276 - 1283Journal Article, 1999, DOI
• Gavin C, Langan Y, Hutchinson M., Cranial and peripheral neuropathy after EBV infection., Postgraduate Medical Journal, 73, (861), 1997, p419 - 420Journal Article, 1997, DOI
• Langan Y, Sudden unexpected death in epilepsy(SUDEP): risk factors and case control studies, Seizure, 9, (3), 2000, p179 - 183Journal Article, 2000, DOI
• Brett F, Chen D, Loftus T, Langan Y, Looby S, Hutchinson S, Intravascular large B cell lymphoma presenting clinically as rapidly progressive dementia., Irish Journal of Medical Science, 187, (2), 2018, p319 - 322Journal Article, 2018, DOI
• Moloney PB, Hutchinson S, Heskin J, Mulcahy F, Langan Y, Conlon NP, Linas BP, Takashi C, Cervantes-Arslanian AM., Possible N methyl D asparatate receptor antibody mediated encephalitis in the setting of HIV cerebrospinal escape., Journal of Neurology, 267, (5), 2020, p1348 - 1352Journal Article, 2020, DOI
• Langan Y, Nashef L., Sudden unexpected death in epilepsy, Neurology Reviews International, 3, 1999, p5 - 8Journal Article, 1999
• Lhatoo SD, Langan Y, Sander JWAS, Sudden death in epilepsy- an overview, Brazilian Journal of Epilepsy and Clinical Neurophysiology, 4, 1998, p167 - 170Journal Article, 1998
• Lhatoo SD, Langan Y, Sander JWAS, Sudden unexpected death in epilepsy, Postgraduate Medical Journal, 75, (890), 1999, p706 - 709Journal Article, 1999, DOI
• Langan Y, Nashef L., Sudden unexpected death in epilepsy, Advances in Clinical Neuroscience and Rehabilitation, 2, 2003, p6 - 8Journal Article, 2003
• Bergin P, Langan Y, Beghi E, Donner E, Cock H, D'Souza W, Thomas R, Scragg R, Invitiation to participate in a prospective case control study of sudden unexpected death in epilepsy, Epilepsia, 62, (5), 2021, p1280 - 1281Journal Article, 2021, DOI
• Sudden unexpected death in epilepsy in, editor(s)S Shorvon, D Fish, E Dodson, E Perucca , Epilepsy Treatment 2nd Edition, UK, Oxford: Blackwell, 2004, pp43 - 49, [Langan Y, Nashef L.]Book Chapter, 2004
• Langan Y, Nashef L, Sander JWAS, The certification of deaths due to epilepsy, Association of British Neurologists, London, April 1999, 1999Poster, 1999
• Langan Y, Gholkar A, Ellison D, Jenkins A, Schofield I, Lai M., New onset non-epileptic attacks after successful epilepsy surgery., Association of British Neurologists, London, March 2004, 2004Poster, 2004
• Lonergan R, Ferguson D, Byrne S, Bradley D, Langan Y, Redmond J., Diagnosis of Friedrich's Ataxia in late onset progressive cerebellar ataxia, Neurology, American Academy of Neurology, Washington DC, April 2015, 84, (14), 2015Poster, 2015, URL
• Munteau T, Redmond J, Langan Y, Brett F, Periodic muscle paralysis- a different perspective, American Academy of Neurology, Washington DC, April 2015, 2015Poster, 2015, URL
• O Dowd S, Munteau T, Hardiman D, Langan Y, Brett F, Redmond J., Ockham's razor of Hickham's dictum? The diagnostic journey of a patient with proximal myopathy, Association of British Neurologists, 2015Poster, 2015, URL
• O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, EEG findings in vasovagal syncope, Irish Gerontological Society, 2011Poster, 2011, URL
• Togher Z, Redmond A, Troy E, Penugonda M, Crumlish N, Langan Y, Hutchinson S., A case of Urbach Wiethe disease asssociated with ictal fear, Neurology, American Academy of Neurology, Toronto, 2020, 2021Poster, 2021, URL
• Monaghan B, Chalissery A, Brett F, Langan Y, Redmond J., Congenital myasthenic syndrome presenting in the sixth decade, American Academy of Neurology, Boston, 2017, 2017Poster, 2017, URL
• Moloney P, Heskin J, Langan Y, Conlon NP, Mulcahy F, Hutchinson S, NMDAR encepalitis associated with HIV CNS escape., American Academy of Neurology, Philadelphia, April 2019, 2019Poster, 2019, URL
• O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, Does amnesia for loss of consciousness occur with vasovagal syncope?, Journal of Cardiovascular Electrophysiology, Venice Arrhythmias 2011, Venice, 2011Poster, 2011, URL
• O Dwyer C, Bennett K, Langan Y, Fan CW, Kenny RA, Electroencephalographic findings in different age groups with vasovagal syncope, Journal of Cardiovascular Electrophysiology, Venice Arrhythmias 2011, Venice, 2011, 2011Poster, 2011, URL
• Langan Y, Nashef L, Sander JWAS, Prevention of sudden unexpected death in epilepsy, Journal of Neurology, Neurosurgery and Psychiatry, Association of British Neurologists , Cape Town, January 2003, 2003Oral Presentation, 2003, URL
• Canavan J, Langan Y, Epilepsy mortality in Ireland, Irish Neurological Association , Limerick, May 2016, 2016Poster, 2016
• O Donnell M, Hunt I, McKenna MC, Armstrong C, Flynn C, Leonard N, Cryan J, Langan Y Redmond J., When you cannot 'keep your chin up'. An unusual case of head drop., Irish Neurological Association, virtual, October 2020, 2020Poster, 2020
• Lambert RJ, Laffan A, Thijs RD, Sander JW, Langan Y, Circadian seizure patterns in SUDEP: Patients with nocturnal seizures are at highest risk., Epilepsia, 29th International Epilepsy Congress, Rome, 52, (6), 2011, pp4 - 22Oral Presentation, 2011, URL
• Donohue, F., Doherty, C., Langan, Y., White, M., White, M., Morrow, S., Hayes, C., Mortality due to sudep and status epilepticus, Irish Medical Journal, 106, (3), 2013, p1-2Journal Article, 2013
• Langan, Y., Sander, J.W.A.S., Sudden unexpected death in patients with epilepsy: Definition, epidemiology and therapeutic implications, CNS Drugs, 13, (5), 2000, p337-349Journal Article, 2000, DOI
• , Cranial and peripheral neuropathy due to Epstein-Barr virus infection., Postgraduate medical journal, 1997Journal Article, 1997, DOI
• Langan Y., Lynn E., The incidence of sudden unexpected death in epilepsy (SUDEP) in the Republic of Ireland, Seizure, 122, 2024, p34 - 38, p34-38Journal Article, 2024, DOI
• McGonigle O., Russell C., Langan Y., Advice following a possible first seizure: what do patients attending for EEG remember?, Seizure, 113, 2023, p19 - 22, p19-22Journal Article, 2023, DOI
• C O'Dwyer, K Bennett, Y Langan, CW Fan, RA Kenny., Amnesia for loss of consciousness is common in vasovagal syncope., Europace, 13, (7), 2011, p1040 - 1045Journal Article, 2011, DOI , TARA - Full Text
• Donohue F, Doherty C, Langan Y, White M, Morrow S, White M, Hayes CB , Mortality from SUDEP and Status Epilepticus in Ireland, Irish Medical Journal, 106, (3), 2013, p91 - 92Journal Article, 2013, URL , TARA - Full Text

• Langan Y, SUDEP and Alcohol, Royal Society of Medicine Epilepsy session, RSM, London, 26/01/21, 2021, B McDonaldInvited Talk

I have a particular interest in epilepsy mortality and sudden unexpected death in epilepsy (SUDEP) has been a major focus of my research. I was responsible for the design, conduct and analysis of a case control study examining risk factors for SUDEP, the largest such study to date which has established me as an expert in the field. I was awarded the Hastings Fellowship in support of this work which was also supported by the UK charity Epilepsy Bereaved. This work made a significant contribution to the body of knowledge on the subject and has informed guidelines such as those produced by NICE. This work led to international collaboration with with other experts as part of the work of the International League against Epilepsy(ILAE) commission on epidemiology. I have supported and supervised a Research Fellow in the Department of Clinical Neurophysiology to investigate the role of baroreceptor sensitivity in the genesis of SUDEP, work which was successfully awarded MD and which was supporting by funding from Epilepsy Ireland. This work was awarded the Kirker prize in epilepsy at the Irish Neurological Association meeting in 2013. I have undertaken a study on epilepsy mortality in Ireland in collaboration with the Health Research Board(HRB)and the Irish coroners. We have examined coronial records from 2019 in order to identify and categorise deaths in those with epilepsy with a particular focus on epilepsy related deaths. This work is supported by a grant from the Irish Institute of Clinical Neuroscience and Epilepsy Ireland. This work has resulted in a publication of the incidence of SUDEP in Ireland with work ongoing on other epilepsy related deaths. Presently I am on the steering committee of an International multicentre case control study in SUDEP coordinated by Prof. Peter Bergin in New Zealand and am awaiting ethics approval to identify Irish cases. I am examining EEG changes in those undergoing CAR-T therapy. Further work on this topic will be undertaken with Dr Roisin McMackin of the McMackin Institute. I am one of a number of principal investigators from a number of schools who have been awarded a TRDA undertaking research into disorders of brain development across the lifespan.

• Title

  The incidence of sudden unexpected death in epilepsy (SUDEP) in Ireland
  Summary

  This work was undertaken in collaboration with the Health Research Board and coronial records form 2019 were examined to allow the identification of SUDEP cases and the subsequent calculation of an incidence rate for Ireland.
  Funding Agency

  Epilepsy Ireland, Irish Institute of Clinical Neuroscience
  Date From

  2019
  Date To

  2025
• Title

  Case control study of SUDEP
  Summary

  International SUDEP case control study
• Title

  EEG in CAR-T patients
  Summary

  To examine whether EEG changes in patients being treated with CAR-T are predictive of ICANS
  Funding Agency

  Consultant Innovation fund
• Title

  ultra long EEG
  Summary
  Funding Agency

  Innovation funding
• Title

  Case control study of SUDEP
  Summary

  UK wide case control study of SUDEP to identify risk factors
  Funding Agency

  Hastings fellowhip
• Title

  Epilepsy related deaths in Ireland
  Summary

  In collaboration with the HRB coronial records for 2019 have been examined in an effort to identify non SUDEP epilepsy related deaths.
  Funding Agency

  Epilepsy Ireland, Irish Institute of Clinical Neuroscience
  Date From

  2020
• Title

  Baroreceptor sensitivity in epilepsy
  Summary

  examine whether baroreceptor sensitivity is altered on those with epilepsy and whether this is important in SUDEP
  Funding Agency

  Epilepsy Ireland
• Title

  Disorders of brain development across the slifespan: insights from rare genetic conditions
  Summary
  Funding Agency

  TRDA
  Date From

  01/09/2025
  Date To

  01/09/2030

Neurology and neuromuscular diseases, Neurosciences, Epidemiology,

• Royal College of Physicians of Ireland present
• International League against Epilepsy present
• Fellowhip Royal College of Physicians of Ireland
• The Irish Institute of Clinical Neuroscience present
• Irish Society of Clinical Neurophysiology present