Annual Overview of Doctoral Health Research 2022

Celebrating the foundational work of the School’s 200 PhD and MD doctoral researchers, the Annual Overview of Doctoral Health Research 2022 emphasises Trinity's commitment to being a research-led school supported by strong clinical-academic partnerships and translational research. Featured projects include sarcopenia and physical activity interventions in community-dwelling older adults, innate immune training against tuberculosis, neutrophil subtypes in ANCA-associated vasculitis, digital health adoption in epilepsy self-management, gamified patient-reported outcome measures (IMPORT) in paediatric oncology, and drug repurposing of metformin to target cancer cell metabolism in rectal cancer radiation therapy.

Read about some of the research topics currently being investigated by our 2022 PhD cohort below.

• Supporting physical function in community-dwelling older adults – a focus on health inequalities and underserved groups

• Defining the consequences of innate immune training on protective versus pathogenic T cell responses in patients with tuberculosis

• Cross-Disease Assessment of Phenotypic and Functional Granulocyte Heterogeneity

• Electroencephalographic Biomarkers for Tracking Cognitive Network Dysfunction in Amyotrophic Lateral Sclerosis

• Does the future of epilepsy care lie in eHealth? An examination of attitudes and behaviours towards epilepsy selfmanagement and eHealth tools from the perspectives of people with epilepsy, their carers, and healthcare providers

• Serum resistance of Extra-intestinal Pathogenic Escherichia coli

• What evidence supports the use of art therapy in response to trauma exposed refugee adolescents, aged 10 to 17 years

• The mechanisms of sexual dimorphism in allergic disease and chronic spontaneous urticaria

• The role of the skeletal muscle pump in the relationship between sarcopenia and orthostatic haemodynamics

• An evaluation of the allostatic load framework for quantifying differences in health and longevity

• Monocyte development signature in Rheumatoid and Psoriatic Arthritis

• Development of a return-to-work intervention for women with breast cancer

• Point Of Care Ultrasound For Functional Multi-Organ Evaluation In Neonatal Encephalopathy

• Health Technology Assessment of CD19 CAR T-Cell Therapies in the Irish Healthcare Setting

• The involvement of the immune system in Parkinson’s disease

• Investigating novel therapies for metachromatic leukodystrophy (MLD)

• Physical activity, physical health and clinical phenotype in adults with moderate and severe haemophilia

• Symptomatic hypermobility in children: a move towards improved care pathways and targeted treatment

• Coercion and Involuntary Care: A Study of Involuntary and Voluntary Psychiatry Inpatients in Dublin

• Development and testing of the acceptability and feasibility of a multicomponent intervention to reduce sedentary behaviour in a workplace setting

• Delivering equitable healthcare access for adults experiencing homelessness

• GxE interactions in skin cancer and vitamin D status

• Interactive monitoring of paediatric outcome reporting for radiation and chemo therapies (IMPORT)

• Targeting metabolism for individualised rectal cancer treatment

• Enhancing immunotherapy in Oesophageal Adenocarcinoma through the modulation of immunometabolism with novel small analogue inhibitors Quininib and its analogues

Link to Full 2022 Report:

Annual Overview of Doctoral Health Research 2022