Dr. Patrick Mitchell

Dr. Patrick Mitchell

Senior Lecturer Consultant, Clinical Medicine

Biography

Patrick Mitchell is a senior lecturer/associate professor of medicine and respiratory consultant physician at Trinity College Dublin and Tallaght University Hospital. Graduating from UCD in 2007 with a medical degree he specialised in internal medicine and respiratory medicine. He undertook a two-year clinical and research fellowship at McMaster University under which entailed translational research in airway inflammation and servicing both general respiratory and airway inflammation clinics. He also completed a two-year Medical Doctorate thesis on the role of IL-33 in allergic asthma. Following his fellowship he was appointed clinical assistant professor of medicine at the University of Calgary, Canada where he was director of the airways disease unit. He returned to Ireland to the above mentioned role with his wife and three children. He has authored numerous peer reviewed research manuscripts and co-authored a book chapter on asthma. Dr. Mitchell's clinical interests are in asthma, Chronic Obstructive Pulmonary Disease (COPD), chronic eosinophilic airways disease, autoimmune pulmonary diseases, Sarcoidosis.

Publications and Further Research Outputs

  • Mitchell PD, Das JP, Murphy DJ, Keane MP, Donnelly SC, Dodd JD, Butler MW, Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among emphysema and idiopathic pulmonary fibrosis in smokers., 2015Journal Article, 2015
  • Kent BD, Mitchell PD, McNicholas WT., Hypoxemia in patients with COPD: cause, effects, and disease progression., International journal of chronic obstructive pulmonary disease, 6, 2011, p199-208Journal Article, 2011, DOI
  • Mitchell, P., Leigh, R., A drug safety review of treating eosinophilic asthma with monoclonal antibodies, Expert Opinion on Drug Safety, 18, (12), 2019, p1161-1170Journal Article, 2019, DOI
  • Satia, I., Watson, R., Scime, T., Dockry, R.J., Sen, S., Ford, J.W., Mitchell, P.D., Fowler, S.J., Gauvreau, G.M., O'Byrne, P.M., Smith, J.A., Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma, Journal of Allergy and Clinical Immunology, 144, (3), 2019, p788-795.e1Journal Article, 2019, DOI
  • Leung, E., Mitchell, P.D., Emerging treatment options in severe asthma, Current Respiratory Medicine Reviews, 14, (2), 2018, p64-76Journal Article, 2018, DOI
  • Mitchell, P.D., Salter, B.M., Oliveria, J.P., El-Gammal, A., Tworek, D., Smith, S.G., Sehmi, R., Gauvreau, G.M., O'Byrne, P.M., IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics, International Archives of Allergy and Immunology, 176, (2), 2018, p133-142Journal Article, 2018, DOI
  • Lim, R., Marciniak, S.J., Marcadier, J., Rassl, D., Mitchell, P.D., Time is of the essence: A young man with recurrent pneumothorax and cavitating lung lesions, Annals of the American Thoracic Society, 15, (8), 2018, p988-989Journal Article, 2018, DOI
  • , Epithelial-Derived Cytokines in Asthma., Chest, 2017Journal Article, 2017, DOI
  • , Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017Journal Article, 2017, DOI
  • , Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma., Pharmacology & therapeutics, 2017Journal Article, 2017, DOI
  • , Anti-IgE and Biologic Approaches for the Treatment of Asthma., Handbook of experimental pharmacology, 2017Journal Article, 2017, DOI
  • Tworek, D., Heroux, D., O'Byrne, S.N., Mitchell, P., O'Byrne, P.M., Denburg, J.A., Toll-like receptor-induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma, Clinical and Experimental Allergy, 47, (7), 2017, p900-908Journal Article, 2017, DOI
  • , Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma., American journal of respiratory and critical care medicine, 2016Journal Article, 2016, DOI
  • , Surfactant Protein-D and Asthma., Chest, 2016Journal Article, 2016, DOI
  • , Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma., Clinical pharmacology and therapeutics, 2016Journal Article, 2016, DOI
  • , IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma., Respiratory research, 2016Journal Article, 2016, DOI
  • Tang, W., Smith, S.G., Salter, B., Oliveria, J.P., Mitchell, P., Nusca, G.M., Howie, K., Gauvreau, G.M., O'Byrne, P.M., Sehmi, R., Allergen-induced increases in interleukin-25 and interleukin-25 receptor expression in mature Eosinophils from Atopic asthmatics, International Archives of Allergy and Immunology, 170, (4), 2016, p234-242Journal Article, 2016, DOI
  • Canonica, G.W., Senna, G., Mitchell, P.D., O"Byrne, P.M., Passalacqua, G., Varricchi, G., Therapeutic interventions in severe asthma, World Allergy Organization Journal, 9, (1), 2016, p1-12Journal Article, 2016, DOI
  • Mitchell, P.D., King, T.J., O"Shea, D.B., Subcutaneous emphysema in acute asthma: A cause for concern?, Respiratory Care, 60, (8), 2015, pe141-e143Journal Article, 2015, DOI
  • Mitchell, P.D., Burke, L.M., Kennedy, M.P., Henry, M.T., A case of pulmonary amyloidosis, Thorax, 69, (6), 2014, p600Journal Article, 2014, DOI
  • Harnett, C.M., Hunt, E.B., Bowen, B.R., O'Connell, O.J., Edgeworth, D.M., Mitchell, P., Eustace, J.A., Henry, M.T., Kennedy, M.P., Plant, B.J., Murphy, D.M., A study to assess inhaler technique and its potential impact on asthma control in patients attending an asthma clinic, Journal of Asthma, 51, (4), 2014, p440-445Journal Article, 2014, DOI
  • Mitchell, P.D., Kennedy, M.P., Bronchoscopic management of malignant airway obstruction, Advances in Therapy, 31, (5), 2014, p512-538Journal Article, 2014, DOI
  • Chong, S.G., Mitchell, P., Fabre, A., McDonnell, T.J., Recurrent pneumothoraces in a 65-year-old female: An unusual case of cystic lung disease, European Respiratory Review, 23, (132), 2014, p271-272Journal Article, 2014, DOI
  • Pallin, M., Walsh, S., O'Driscoll, M.F., Murray, C., Cahalane, A., Brown, L., Carter, M., Mitchell, P., McDonnell, T.J., Butler, M.W., Overwhelming support among urban Irish COPD patients for lung cancer screening by low-dose CT scan, Lung, 190, (6), 2012, p621-628Journal Article, 2012, DOI
  • O'Neill, A.C., McCarthy, C., Ridge, C.A., Mitchell, P., Hanrahan, E., Butler, M., Keane, M.P., Dodd, J.D., Rapid needle-out patient- rollover time after percutaneous CT-guided transthoracic biopsy of lung nodules: Effect on pneumothorax rate, Radiology, 262, (1), 2012, p314-319Journal Article, 2012, DOI
  • Slattery, E., Mitchell, P., Mulcahy, H.E., Cigarette smoking in Crohn's disease: Can we do more?, Journal of Crohn's and Colitis, 5, (5), 2011, p505Journal Article, 2011, DOI
  • Lugogo, N., Liu, M.C., Pavord, I., Mitchell, P.D., Smith, S.G., Mallett, S., Albers, F.C., Bradford, E.S., Yancey, S.W., Bel, E.H., Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis, Journal of Allergy and Clinical Immunology: In Practice, 9, (9), 2021, p3506-3509.e3Journal Article, 2021, DOI
  • Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., 2021 Canadian Thoracic Society Guideline"A focused update on the management of very mild and mild asthma, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021Journal Article, 2021, DOI
  • Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021Journal Article, 2021, DOI
  • Upham, J.W., Le Lievre, C., Jackson, D.J., Masoli, M., Wechsler, M.E., Price, D.B., Mansur, A., Detoraki, A., Altraja, A., James, A., Nanzer-Kelly, A., Côté, A., Menzies-Gow, A., Papaioannou, A., Cheffins, A.-M., Bourdin, A., Mahboub, B., Lipworth, B., Celis-Preciado, C.A., Torres-Duque, C., Bucca, C., Porsbjerg, C., Ulrik, C., Corrigan, C., Taube, C., Farah, C., Katelaris, C., Langton, D., Ryan, D., Larenas-Linnemann, D., Zervas, E., Heffler, E., Hoyte, F., Puggioni, F., Christoff, G., Canonica, G.W., Carpagnano, G.E., Guida, G., Katsoulotos, G., Brusselle, G., Rupani, H., Jersmann, H., Clifton, I., Dhariwal, J., Fingleton, J., Duke, J., Rimmer, J., Douglass, J., Fonseca, J., van Boven, J., Corless, J., Harrington, J., Maspero, J., Miguel, J.L., Pipatvech, K., Kenny, K., Chapman, K., Kostikas, K., Lehtimäki, L., Chung, L.P., Heaney, L., Hang, L.-W., Boulet, L.-P., Perez-de-Llano, L., Ricciardi, L., Idrees, M., Milanese, M., Conte, M.E., Costantino, M.T., Siyue, M.K., Fitzgerald, M., Hew, M., Peters, M., Tsai, M.-J., Patel, M., Khan, M.H., Sadatsafavi, M., Al-Ahmad, M., Yacoub, M.-R., De Gennaro, M., Radhakrishna, N., Hanania, N.A., Papadopoulos, N., Lugogo, N., Linaker, N., Crimi, N., Dennison, P., Nair, P., Mitchell, P.D., O'Byrne, P., Pfeffer, P., Kauppi, P., Hughes, P., Middleton, P., Wark, P., Bardin, P., Fu, P.-K., Akuthota, P., Chaudhuri, R., Campos, R., Al-Lehebi, R., Parente, R., Francisco, R., Wenzel, S., Pierachille, S., Pawar, S., Loukides, S., Fowler, S., Mackenzie, T., Brown, T., Lee Tan, T., Björnsdóttir, U., McDonald, V., Lawriwskyj, V., Backer, V., Vasileva, V., Chien, Y.-C., Harrington, Z., Defining a Severe Asthma Super-Responder: Findings from a Delphi Process, Journal of Allergy and Clinical Immunology: In Practice, 2021Journal Article, 2021, DOI
  • Kaplan, A., Mitchell, P.D., Cave, A.J., Gagnon, R., Foran, V., Ellis, A.K., Effective asthma management: Is it time to let the AIR out of SABA?, Journal of Clinical Medicine, 9, (4), 2020Journal Article, 2020, DOI
  • Mitchell PD, Olaniyi J, Buckley C, Donnelly SC., Long COVID syndrome and the lung-How long will it last?, QJM : monthly journal of the Association of Physicians, 2022Journal Article, 2022, DOI
  • Anti-IgE and Biologic Approaches for the Treatment of AsthmaMitchell PD, El-Gammal A, O'Byrne PM.Handbook of Experimental Pharmacology.Pharmacology and therapeutics of asthma and COPD.Springer, United Kingdom., Pharmacology and Therapeutics of Asthma and COPD, 1, United Kingdom, Springer, 2017, 131 - 152ppBook, 2017, URL
  • Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Baeza Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R., MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity., QJM the Quarterly Journal of Medicine, 116, (3), 2023, p205 - 212Journal Article, 2023, DOI , URL
  • Mitchell P.D., Buckley C., Subramaniam A., Crowther S., Donnelly S.C., Elevated serum ACE levels in patients with post-acute COVID-19 syndrome, QJM : monthly journal of the Association of Physicians, 115, (10), 2022, p651 - 652, p651-652Journal Article, 2022, DOI
  • Ellis, A.K., Foran, V., Kaplan, A., Mitchell, P.D., Clarifying SABA overuse: Translating Canadian Thoracic Society guidelines into clinical practice, Allergy, Asthma and Clinical Immunology, 18, (1), 2022Journal Article, 2022, DOI
  • Atwood, C.E., Bhutani, M., Ospina, M.B., Rowe, B.H., Leigh, R., Deuchar, L., Faris, P., Michas, M., Mrklas, K.J., Graham, J., Aceron, R., Damant, R., Green, L., Hirani, N., Longard, K., Meyer, V., Mitchell, P., Tsai, W., Walker, B., Stickland, M.K., Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care Coordinator: A Randomized Clinical Trial, Chest, 162, (2), 2022, p321-330Journal Article, 2022, DOI
  • Whetstone CE, Ranjbar M, Cusack RP, Al-Sajee D, Omer H, Alsaji N, Ho T, Duong M, Mitchell P, Satia I, Keith P, Xie Y, MacLean J, Sommer DD, Gauvreau GM, Protein expression of SARS-CoV-2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge., Allergy, 2023Journal Article, 2023, DOI
  • Pfeffer, P.E., Ali, N., Murray, R., Ulrik, C., Tran, T.N., Maspero, J., Peters, M., Christoff, G.C., Sadatsafavi, M., Torres-Duque, C.A., Altraja, A., Lehtimäki, L., Papadopoulos, N., Salvi, S., Costello, R.W., Cushen, B., Heffler, E., Iwanaga, T., Al-Ahmad, M., Larenas-Linnemann, D., Kuna, P., Fonseca, J.A., Al-Lehebi, R., Rhee, C.K., Perez-de-Llano, L., Perng Steve, D.-W., Mahboub, B., Wang, E., Goh, C., Lyu, J., Newell, A., Alacqua, M., Belevskiy, A.S., Bhutani, M., Bjermer, L., Bjornsdottir, U., Bourdin, A., Bulow, A.V., Busby, J., Canonica, G.W., Cosio, B.G., Dorscheid, D.R., Muñoz-Esquerre, M., FitzGerald, J.M., Gil, E.G., Gibson, P.G., Heaney, L.G., Hew, M., Hilberg, O., Hoyte, F., Jackson, D.J., Koh, M.S., Ko, H.-K.B., Lee, J.H., Lehmann, S., Chaves Loureiro, C., Lúðvíksdóttir, D., Menzies-Gow, A.N., Mitchell, P., Papaioannou, A.I., Popov, T.A., Porsbjerg, C.M., Salameh, L., Sirena, C., Taillé, C., Taube, C., Tohda, Y., Wechsler, M.E., Price, D.B., Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both, Allergy: European Journal of Allergy and Clinical Immunology, 2023Journal Article, 2023, DOI
  • Menzies-Gow, A., Wechsler, M.E., Brightling, C.E., Korn, S., Corren, J., Israel, E., Chupp, G., Bednarczyk, A., Ponnarambil, S., Caveney, S., Almqvist, G., Go""bek, M., Simonsson, L., Lawson, K., Bowen, K., Colice, G., Hetzel, J.L., Fiterman, J., Souza Machado, A., Antila, M.A., Lima, M.A., Minamoto, S.E.T., Blanco, D.C., Bezerra, P.G.D.M., Houle, P.-A., Lemiere, C., Melenka, L.S., Leigh, R., Mitchell, P., Anees, S., Pek, B., Chouinard, G., Cheema, A.S., Yang, W.H.-C., Philteos, G., Chanez, P., Bourdin, A., Devouassoux, G., Taille, C., De Blay, F., Leroyer, C., Beurnier, A., Garcia, G., Girodet, P.-O., Blanc, F.-X., Magnan, A., Wanin, S., Just, J., Linde, R., Zielen, S., Förster, K., Geßner, C., Jandl, M., Buhl, R.O., Kornmann, M.O., Linnhoff, A., Ludwig-Sengpiel, A., Ehlers, M., Schmoller, T., Steffen, H., Hoffmann, M., Kirschner, J., Schmidt, O., Welte, T., Temme, H., Wand, O., Bar-Shai, A., Izbicki, G., Berkman, N., Fink, G., Shitrit, D., Adir, Y., Kuna, P., Rewerska, B., Pisarczyk-Bogacka, E., Kurbacheva, O., Mikhailov, S.L., Vasilev, M., Emelyanov, A., Wali, S., Albanna, A., van Zyl-Smit, R., Abdullah, I., Bernhardi, D., Hoosen, F., Irusen, E., Kalla, I., Lakha, D., Mitha, E., Naidoo, V., Nell, H., Padayachee, T., Reddy, J., Petrick, F., van der Walt, E., Vawda, Z.F.A., Park, H.-S., Lee, S.H., Kim, M.-K., Park, J.-W., Cho, Y.S., Lee, B.J., Chang, Y.-S., Park, C.-S., Lee, K.H., Lee, S.Y., Yoon, H., Sohn, K.H., Park, M.J., Min, K.H., Cho, Y.J., Park, H.K., Lee, Y., Lee, J., Sheu, C.-C., Tu, C.-Y., Lee, K.-Y., Bavbek, S., Gemicioglu, B., Ediger, D., Kalkan, I.K., Makieieva, N., Ostrovskyy, M., Dytyatkovs'ka, Y., Mostovoy, Y.M., Lebed, K., Yakovenko, O., Adams, A., Mooring, T., Torres Jr, L., Sexton, M., Thompson, E., Bernstein, J.A., Lisi, P., Chappel, C.M., Cole, J., Greenwald, G.I., Jones, C., Klein, R.M., Pham, D.N., Spangenthal, S., Weinstein, S.F., Windom, H.H., Kao, N.L., Leong, M.A., Mehta, V., Moore, W.C., Bhat, S., Aish, B., Meltzer, S.M., Moss, M.H., Kerwin, E.M., Delgado, J.P., Lucksinger, G.H., Thompson, C.A., Alpizar, S.A., Vadgama, S.V., Zafar, Z., Jacobs, J.S., Lugogo, N.J., Jain, N., Sher, L.D., Andrawis, N.S., Fuentes, D., Boren, E.J., Gonzalez, E.G., Talreja, N., Durrani, S.S., Sekhsaria, S., DeLeon, S., Shukla, M., Totszollosy Tarpay, M.M., Fakih, F., Hudes, G., Tillinghast, J.P., Korenblat, P.E., Shenoy, K., Que, L., Kureishy, S.A., Umeh, F.C., Nguyen, V.N., Chu, H.T., Nguyen, T.T.D., Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study, The Lancet Respiratory Medicine, 11, (5), 2023, p425-438Journal Article, 2023, DOI
  • Busby, J., Price, D., Al-Lehebi, R., Bosnic-Anticevich, S., van Boven, J.F.M., Emmanuel, B., Fitzgerald, J.M., Gaga, M., Hansen, S., Hew, M., Iwanaga, T., Linnemann, D.L., Mahboub, B., Mitchell, P., Morrone, D., Pham, J., Porsbjerg, C., Roche, N., Wang, E., Eleangovan, N., Heaney, L.G., Impact of socioeconomic status on adult patients with asthma: A population-based cohort study from uk primary care, Journal of Asthma and Allergy, 14, 2021, p1375-1388Journal Article, 2021, DOI
  • Gauvreau GM, Sehmi R, FitzGerald JM, Leigh R, Cockcroft DW, Davis BE, Mayers I, Boulet LP, Al-Sajee D, Salter BM, Cusack R, Ho T, Whetstone C, Alsaji N, Satia I, Killian KJ, Mitchell PD, Magee IP, Bergeron C, Bhutani M, Werkström V, Dur"y"ski T, Shoemaker K, Katial RK, Jison M, Newbold P, McCrae C, O'Byrne PM., Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled, trial., The European respiratory journal, 2024, p2400512Journal Article, 2024, DOI
  • Denton E, Hew M, Peters MJ, Upham JW, Bulathsinhala L, Tran TN, Martin N, Bergeron C, Al-Ahmad M, Altraja A, Larenas-Linnemann D, Murray R, Celis-Preciado CA, Al-Lehebi R, Belhassen M, Bhutani M, Bosnic-Anticevich SZ, Bourdin A, Brusselle GG, Busby J, Canonica GW, Heffler E, Chapman KR, Charriot J, Christoff GC, Chung LP, Cosio BG, Côté A, Costello RW, Cushen B, Fingleton J, Fonseca JA, Gibson PG, Heaney LG, Huang EW, Iwanaga T, Jackson DJ, Koh MS, Lehtimäki L, Máspero J, Mahboub B, Menzies-Gow AN, Mitchell PD, Papadopoulos NG, Papaioannou AI, Perez-de-Llano L, Perng DW, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Roche N, Sadatsafavi M, Salvi S, Schmid JM, Sheu CC, Sirena C, Torres-Duque CA, Salameh L, Patel PH, Ulrik CS, Wang E, Wechsler ME, Price DB, ISAR LUMINANT Working Group., Real-world biologics response and super-response in the International Severe Asthma Registry cohort., Allergy, 2024Journal Article, 2024, DOI
  • O'Brien S, Musameh K, El Obeid M, Butler T, Armstrong M, Cunningham Z, Atzinger A, Kuwert T, Mitchell PD, Donnelly SC., Fibroblast activation in sarcoidosis as assessed by 68Ga-FAPI (fibroblast activation protein inhibitor)-46 PET/CT., QJM : monthly journal of the Association of Physicians, 2024, phcae067Journal Article, 2024, DOI
  • Bourdin A, Brusselle G, Couillard S, Fajt ML, Heaney LG, Israel E, McDowell PJ, Menzies-Gow A, Martin N, Mitchell PD, Petousi N, Quirce S, Schleich F, Pavord ID., Phenotyping of Severe Asthma in the Era of Broad-Acting Anti-Asthma Biologics., The journal of allergy and clinical immunology. In practice, 12, (4), 2024, p809-823Journal Article, 2024, DOI
  • Wechsler ME, Scelo G, Larenas-Linnemann DES, Torres-Duque CA, Maspero J, Tran TN, Murray RB, Martin N, Menzies-Gow AN, Hew M, Peters MJ, Gibson PG, Christoff GC, Popov TA, Côté A, Bergeron C, Dorscheid D, FitzGerald JM, Chapman KR, Boulet LP, Bhutani M, Sadatsafavi M, Jiménez-Maldonado L, Duran-Silva M, Rodriguez B, Celis-Preciado CA, Cano-Rosales DJ, Solarte I, Fernandez-Sanchez MJ, Parada-Tovar P, von Bülow A, Bjerrum AS, Ulrik CS, Assing KD, Rasmussen LM, Hansen S, Altraja A, Bourdin A, Taille C, Charriot J, Roche N, Papaioannou AI, Kostikas K, Papadopoulos NG, Salvi S, Long D, Mitchell PD, Costello R, Sirena C, Cardini C, Heffler E, Puggioni F, Canonica GW, Guida G, Iwanaga T, Al-Ahmad M, García U, Kuna P, Fonseca JA, Al-Lehebi R, Koh MS, Rhee CK, Cosio BG, Perez de Llano L, Perng DS, Huang EW, Wang HC, Tsai MJ, Mahboub B, Salameh LIJ, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Goddard AG, Wang E, Hoyte FCL, Chapman NM, Katial R, Carter V, Bulathsinhala L, Eleangovan N, Ariti C, Lyu J, Porsbjerg C, Price DB., Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma., American journal of respiratory and critical care medicine, 209, (3), 2024, p262-272Journal Article, 2024, DOI
  • Scelo G, Torres-Duque CA, Maspero J, Tran TN, Murray R, Martin N, Menzies-Gow AN, Hew M, Peters MJ, Gibson PG, Christoff GC, Popov TA, Côté A, Bergeron C, Dorscheid D, FitzGerald JM, Chapman KR, Boulet LP, Bhutani M, Sadatsafavi M, Jiménez-Maldonado L, Duran-Silva M, Rodriguez B, Celis-Preciado CA, Cano-Rosales DJ, Solarte I, Fernandez-Sanchez MJ, Parada-Tovar P, von Bülow A, Bjerrum AS, Ulrik CS, Assing KD, Rasmussen LM, Hansen S, Altraja A, Bourdin A, Taille C, Charriot J, Roche N, Papaioannou AI, Kostikas K, Papadopoulos NG, Salvi S, Long D, Mitchell PD, Costello R, Sirena C, Cardini C, Heffler E, Puggioni F, Canonica GW, Guida G, Iwanaga T, Al-Ahmad M, Linnemann DL, Garcia U, Kuna P, Fonseca JA, Al-Lehebi R, Koh MS, Rhee CK, Cosio BG, de Llano LP, Perng Steve DW, Huang EW, Wang HC, Tsai MJ, Mahboub B, Salameh LIJ, Jackson D, Busby J, Heaney LG, Pfeffer P, Goddard AG, Wang E, Hoyte F, Wechsler ME, Chapman N, Katial R, Carter V, Bulathsinhala L, Eleangovan N, Ariti C, Lyu J, Price DB, Porsbjerg C., Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry., Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 132, (1), 2024, p42-53Journal Article, 2024, DOI
  • Shane O"Brien, Carol Buckley, Thomas Butler, Zara Cunningham, Sara Keane, Emma McArdle, Patrick Mitchell, Seamas C Donnelly, Persistent diaphragmatic weakness and peripheral muscle weakness are associated with anosmia in the Long-COVID syndrome, QJM: An International Journal of Medicine, 2023Journal Article, 2023, DOI
  • Musameh, K, Donnelly, SC, Mitchell, P, O'Brien, S, Butler, T, Atzinger, A, Mehboob, R, Kuwert, T, Evaluation of Fibroblast Activation Protein-Specific PET/CT in a Patient With Post-covid Pneumonitis, A53. CASE REPORTS IN ILD, 2024Book Chapter, 2024, DOI
  • Musameh K, O'Brien SP, Butler T, Buckley O, Noone A, Donnelly SC, Rheumatoid Arthritis-Associated Interstitial Lung Disease: An overview., QJM : monthly journal of the Association of Physicians, 2025Journal Article, 2025, DOI
  • Désirée Larenas"Linnemann, Chin Kook Rhee, Alan Altraja, John Busby, Trung N. Tran, Eileen Wang, Todor A. Popov, Patrick Mitchell, Paul Pfeffer, Roy A. Pleasants, Rohit Katial, Mariko Siyue Koh, Arnaud Bourdin, Florence Schleich, Jorge Máspero, Mark Hew, Matthew Peters, David J. Jackson, George Christoff, Luis Pérez de Llano, Iván Chérrez-Ojeda, João Fonseca, Richard W. Costello, Carlos A. Torres-Duque, Piotr Kuna, Andrew Menzies"Gow, Neda Stjepanovic, Peter G. Gibson, Paulo Márcio Pitrez, Céline Bergeron, Celeste Porsbjerg, Camille Taillé, Christian Taube, Nikolaos G. Papadopoulos, Andriana ". Papaioannou, Sundeep Salvi, Giorgio Walter Canonica, Enrico Heffler, Takashi Iwanaga, Mona Al"Ahmad, Sverre Lehmann, Riyad Al"Lehebi, Borja G. Cosío, Diahn"Warng Perng, Bassam Mahboub, Liam G. Heaney, Pujan H. Patel, Njira Lugogo, Michael E. Wechsler, Lakmini Bulathsinhala, Victoria Carter, Kirsty Fletton, David L. Neil, Ghislaine Scélo, David Price, International Severe Asthma Registry (ISAR): 2017"2024 Status and Progress Update, Tuberculosis & respiratory diseases, 88, (2), 2025, p193 - 215, p193-215Journal Article, 2025, DOI
  • Rebecca O"Leary, Brianne Philipenko, J. Michael Ramsahai, Patrick Mitchell, Mepolizumab to benralizumab: A case series of a biologic switch in severe asthma, Canadian Journal of Respiratory Critical Care and Sleep Medicine, 9, (2), 2025, p77 - 84, p77-84Journal Article, 2025, DOI
  • Bodiabaduge A. P. Jayasekera, Jehill Parikh, Tamara Modebadze, Anderson Brito da Silva, Renae J. Stefanetti, John Crossman, Damian Holliman, Mohammed Ali Hussain, Alistair Jenkins, Ottó Major, Patrick Mitchell, Claire Nicholson, Nicholas A. Ross, Dorothy Wallace, Louise Ward, Tim Hodgson, Mark R. Baker, Gráinne S. Gorman, Andrew M. Blamire, Mark O. Cunningham, Christopher J. A. Cowie, Fiona E. N. LeBeau, Elevated glioma-related cortical glutamate in vivo is associated with ex vivo interictal discharges in human brain slices, Brain Communications, 7, (6), 2025, pfcaf451 - fcaf451, pfcaf451-fcaf451Journal Article, 2025, DOI
  • John Murray, S O"Brien, Patrick Mitchell, Diffuse Alveolar Hemorrhage, Seminars in Respiratory and Critical Care Medicine, 2025Journal Article, 2025, DOI
  • Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scélo, David Price, , Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scelo, Ming"Ju Tsai, John Busby, Benjamin Emmanuel, Liam G. Heaney, Christine Jenkins, Flavia Hoyte, Giorgio Walter Canonica, Rohit Katial, Enrico Heffler, Eileen Wang, Francesca Puggioni, Michael E. Wechsler, Ledit Ardusso, Jorge Máspero, Martín Sívori, Cathy Emmas, Andrew Menzies"Gow, Neda Stjepanovic, Sinthia Bosnic"Anticevich, Belinda Cochrane, Eve Denton, Peter G. Gibson, Mark Hew, Peter G. Middleton, Matthew Peters, Guy Brusselle, Renaud Louis, Florence Schleich, George Christoff, Todor A. Popov, Céline Bergeron, Mohit Bhutani, Kenneth R. Chapman, Andréanne Côté, Simon Couillard, Delbert R. Dorscheid, Libardo Jiménez-Maldonado, Iván Solarte, Carlos A. Torres"Duque, Susanne Hansen, Celeste Porsbjerg, Charlotte Suppli Ulrik, Alan Altraja, Arnaud Bourdin, Konstantinos Exarchos, Athena Gogali, "onstantinos "ostikas, "ichael "akris, Andriana ". Papaioannou, Patrick Mitchell, Takashi Iwanaga, Tatsuya Nagano, Yuji Tohda, Mona Al"Ahmad, Désirée Larenas"Linnemann, Bernt Bøgvald Aarli, Piotr Kuna, Cláudia Chaves Loureiro, Riyad Al"Lehebi, Adeeb A. Bulkhi, Wenjia Chen, Yah Ru Juang, Mariko Siyue Koh, Anqi Liu, Chin Kook Rhee, Borja G. Cosío, Luis Perez- de-Llano, Diahn"Warng Perng, Chau"Chyun Sheu, Hao"Chien Wang, Bassam Mahboub, Laila Salameh, D.J. Jackson, Pujan H. Patel, Paul E Pfeffer, Njira Lugogo, Roy A. Pleasants, Aaron Beastall, Lakmini Bulathsinhala, Victoria Carter, Nevaashni Eleangovan, Kirsty Fletton, John Townend, Ruth Murray, David Price, Reply to Liu et al., Zhou et al., and Dong et al., American Journal of Respiratory and Critical Care Medicine, 212, (3), 2025, p673 - 674, p673-674Journal Article, 2025, DOI
  • Mohsen Sadatsafavi, Trung N. Tran, Ghislaine Scélo, Ming"Ju Tsai, John Busby, Benjamin Emmanuel, Liam G. Heaney, Christine Jenkins, Flavia Hoyte, Giorgio Walter Canonica, Rohit Katial, Enrico Heffler, Eileen Wang, Francesca Puggioni, Michael E. Wechsler, Ledit Ardusso, Jorge Máspero, Martín Sívori, Cathy Emmas, Andrew Menzies"Gow, Neda Stjepanovic, Sinthia Bosnic"Anticevich, Belinda Cochrane, Eve Denton, Peter G. Gibson, Mark Hew, Peter G. Middleton, Matthew Peters, Guy Brusselle, Renaud Louis, Florence Schleich, George Christoff, Todor A. Popov, Céline Bergeron, Mohit Bhutani, Kenneth R. Chapman, Andréanne Côté, Simon Couillard, Delbert R. Dorscheid, Libardo Jiménez-Maldonado, Iván Solarte, Carlos A. Torres"Duque, Susanne Hansen, Celeste Porsbjerg, Charlotte Suppli Ulrik, Alan Altraja, Arnaud Bourdin, Konstantinos Exarchos, Athena Gogali, "onstantinos "ostikas, "ichael "akris, Andriana ". Papaioannou, Patrick Mitchell, Takashi Iwanaga, Tatsuya Nagano, Yuji Tohda, Mona Al"Ahmad, Désirée Larenas"Linnemann, Bernt Bøgvald Aarli, Piotr Kuna, Cláudia Chaves Loureiro, Riyad Al"Lehebi, Adeeb A. Bulkhi, Wenjia Chen, Yah Ru Juang, Mariko Siyue Koh, Anqi Liu, Chin Kook Rhee, Borja G. Cosío, Luis Pérez de Llano, Diahn"Warng Perng, Chau"Chyun Sheu, Hao"Chien Wang, Bassam Mahboub, Laila Salameh, David J. Jackson, Pujan H. Patel, Paul Pfeffer, Njira Lugogo, Roy A. Pleasants, Aaron Beastall, Lakmini Bulathsinhala, Victoria Carter, Nevaashni Eleangovan, Kirsty Fletton, John Townend, Ruth Murray, David Price, Prevention of Cardiovascular and Other Systemic Adverse Outcomes in Patients with Asthma Treated with Biologics, American Journal of Respiratory and Critical Care Medicine, 211, (7), 2025, p1165 - 1174, p1165-1174Journal Article, 2025, DOI
  • David Price, B. Emmanuel, G. Scelo, Alan Altraja, Belinda Cochrane, Wenjia Chen, Mariko Siyue Koh, I. Solarte Rodriguez, Ming"Ju Tsai, Charlotte Suppli Ulrik, Céline Bergeron, George Christoff, Athena Gogali, Susanne Hansen, Mark Hew, Rohit Katial, L. Perez-De-Llano, Francesca Puggioni, Adeeb A. Bulkhi, Aurore Côté, Cathy Emmas, Liam G. Heaney, Laura Gonzalez-Maldonado, Patrick Mitchell, Andriana ". Papaioannou, Florence Schleich, Chau"Chyun Sheu, Jorge Máspero, P.G. Gibson, Carlos A. Torres"Duque, Celeste Porsbjerg, Arnaud Bourdin, Giorgio Walter Canonica, Takashi Iwanaga, Désirée Larenas"Linnemann, Piotr Kuna, Riyad Al"Lehebi, Chin Kook Rhee, Borja G. Cosío, Diahn"Warng Perng, Bassam Mahboub, John Busby, David J. Jackson, P.H. Patel, Paul Pfeffer, Kirsty Fletton, R. Murray, John Townend, T.N. Tran, Enrico Heffler, Impact of Biologic Initiation on New-onset of Corticosteroid-related Adverse Effects in Patients With Severe Asthma, American Journal of Respiratory and Critical Care Medicine, 211, (Supplement_1), 2025, pA5552 - A5552, pA5552-A5552Journal Article, 2025, DOI
  • Wenjia Chen, Trung N. Tran, John Townend, George Christoff, Ming-Ju Tsai, Alan Altraja, Belinda Cochrane, Borja G. Cosío, Martín Sívori, Ruth Murray, "ichael "akris, Ghislaine Scélo, Lakmini Bulathsinhala, Ledit Ardusso, María Eugenia Franchi, Jorge Máspero, Fernando Saldarini, Ana María Stok, Ana Giselle Tomaszuk, Anahí Yañez, Benjamin Emmanuel, Cathy Emmas, "onstantinos "ostikas, Andrew Menzies"Gow, Neda Stjepanovic, Sinthia Bosnic"Anticevich, Eve Denton, Peter G. Gibson, Mark Hew, Christine Jenkins, Peter G. Middleton, Matthew Peters, John W. Upham, Guy Brusselle, Renaud Louis, Florence Schleich, Paulo Márcio Pitrez, Todor A. Popov, Céline Bergeron, Mohit Bhutani, Kenneth R. Chapman, Andréanne Côté, Simon Couillard, Delbert R. Dorscheid, M. Diane Lougheed, Mohsen Sadatsafavi, Carlos Andrés Celis-Preciado, Libardo Jiménez-Maldonado, Bellanid Rodríguez-Cáceres, Diana Jimena Cano Rosales, Iván Solarte, Carlos A. Torres"Duque, Susanne Hansen, Celeste Porsbjerg, Charlotte Suppli Ulrik, Arnaud Bourdin, Petros Bakakos, Konstantinos Exarchos, Athena Gogali, Aggelos Ladias, Nikolaos G. Papadopoulos, Andriana ". Papaioannou, Richard W. Costello, Breda Cushen, Patrick Mitchell, Giorgio Walter Canonica, Enrico Heffler, Francesca Puggioni, Takashi Iwanaga, Tatsuya Nagano, Yuji Tohda, Mona Al"Ahmad, Désirée Larenas"Linnemann, Bernt Bøgvald Aarli, Sverre Lehmann, Piotr Kuna, José Alberto Ferreira, João Fonseca, Cláudia Chaves Loureiro, Riyad Al"Lehebi, Adeeb A. Bulkhi, Yah Ru Juang, Mariko Siyue Koh, Anqi Liu, Chin Kook Rhee, Luis Pérez de Llano, Pin"Kuei Fu, Diahn"Warng Perng, Chau"Chyun Sheu, Hao"Chien Wang, Bassam Mahboub, Laila Salameh, John Busby, Liam G. Heaney, David J. Jackson, Pujan H. Patel, Paul Pfeffer, Flavia Hoyte, Rohit Katial, Njira Lugogo, Impact of Biologics Initiation on Oral Corticosteroid Use in the International Severe Asthma Registry and the Optimum Patient Care Research Database: A Pooled Analysis of Real-World Data, The Journal of Allergy and Clinical Immunology In Practice, 13, (8), 2025, p2033 - 2048, p2033-2048Journal Article, 2025, DOI
  • Eimear Foley, A Basirat, Ankit Yadav, S O"Brien, Patrick Mitchell, Seamas C. Donnelly, A case of pulmonary and cutaneous sarcoidosis, Breathe, 21, (2), 2025, p240228 - 240228, p240228-240228Journal Article, 2025, DOI
  • S. O'Brien, Khaled Musameh, Michel Obéid, Thomas Bütler, Armin Atzinger, Torsten Kuwert, Michelle E. Armstrong, Patrick Mitchell, Seamas C. Donnelly, 68 Ga-FAPi (Fibroblast-Activation-Protein Inhibitors) Pet/CT Scan Detection of Fibroblast Activity in a Case of Active Multisystem Sarcoidosis, 2024, pA5925 - A5925, pA5925-A5925Journal Article, 2024, DOI
  • Khaled Musameh, S O"Brien, Roshane Mehboob, Thomas Bütler, Z Cunningham, Carol Buckley, Armin Atzinger, Torsten Kuwert, Patrick Mitchell, Seamas C. Donnelly, Evaluation of fibroblast activation protein"specific PET/CT in a patient with post"COVID pneumonitis, Respirology Case Reports, 12, (9), 2024, pe01446 - e01446, pe01446-e01446Journal Article, 2024, DOI
  • Eve Denton, Mark Hew, R. Murray, L. Bulathsinhala, T.N. Trung, N. Martin, Mona Al"Ahmad, Alan Altraja, C.A. Celis-Preciado, Riyad Al"Lehebi, C. Bergeron, Sinthia Bosnic"Anticevich, Arnaud Bourdin, Guy Brusselle, Joe Busby, Giorgio Walter Canonica, Jérémy Charriot, George Christoff, Li Ping Chung, Borja G. Cosío, Richard W. Costello, Breda Cushen, Joaquím Fonseca, P.G. Gibson, Liam G. Heaney, Takashi Iwanaga, Magdalene Koh, Lauri Lehtimäki, Jorge Máspero, Bassam Mahboub, Patrick Mitchell, Nikolaos G. Papadopoulos, L. Perez-De-Llano, Diahn-Wang Perng, Matthew Peters, Paul Pfeffer, Todor A. Popov, Celeste Porsbjerg, Chin Kook Rhee, N. Roche, Mohsen Sadatsafavi, S.S. Salvi, Chau"Chyun Sheu, Carlos A. Torres"Duque, Charlotte Suppli Ulrik, John W. Upham, E. Wang, M.E. Wechsler, David Price, on behalf of the LUMINANT Working Group, Biologic Responders and Super-responders in the International Severe Asthma Registry, 2023, pA4753 - A4753, pA4753-A4753Journal Article, 2023, DOI
  • Cathal John Hannan, Abdurrahman I. Islim, Andrew F. Alalade, Andrew Bacon, Anthony Ghosh, Arthur J. Dalton, Ashraf Abouharb, Daniel Walsh, Diederik Bulters, Edward White, Emmanouil Chavredakis, George Kounin, Giles Critchley, Graham Dow, Hiren C. Patel, Howard L. Brydon, Ian Anderson, Ioannis Fouyas, James Galea, Jerome St George, Jarnail Bal, Krunal Patel, Mahmoud Kamel, Mario Teo, Noel Fanning, Nitin Mukerji, Patrick Grover, Patrick Mitchell, Peter C. Whitfield, Rikin Trivedi, Matthew Crockett, Paul Brennan, Mohsen Javadpour, Radiological follow-up of endovascularly treated intracranial aneurysms: a survey of current practice in the UK and Ireland, Acta Neurochirurgica, 165, (2), 2022, p451 - 459, p451-459Journal Article, 2022, DOI
  • David Price, Paul Pfeffer, Nasloon Ali, Ruth Murray, Charlotte Suppli Ulrik, Trung N. Tran, Jorge Máspero, Matthew Peters, George Christoff, Mohsen Sadatsafavi, Carlos A. Torres"Duque, Alan Altraja, Lauri Lehtimäki, Nikolaos G. Papadopoulos, Sundeep Salvi, Richard W. Costello, Breda Cushen, Enrico Heffler, Takashi Iwanaga, Mona Al"Ahmad, Désirée Larenas"Linnemann, Piotr Kuna, João Fonseca, Riyad Al"Lehebi, Chin Kook Rhee, Luis Pérez de Llano, Diahn-Wang Perng, Bassam Mahboub, Eileen Wang, Yun Yi Celine Goh, Juntao Lyu, A Newell, Marianna Alacqua, Mohit Bhutani, Leif Bjermer, Unnur Steina Björnsdóttir, Arnaud Bourdin, Anna von Bülow, John Busby, Giorgio Walter Canonica, Borja G. Cosío, Delbert R. Dorscheid, Mariana Muñoz Esquerre, Mark Fitzgerald, Esther García Gil, Peter G. Gibson, Liam G. Heaney, Mark Hew, Ole Hilberg, Flavia Hoyte, David J. Jackson, Mariko Siyue Koh, Hsin"Kuo Ko, Jaeha Lee, Sverre Lehmann, Claudia Chaves Loureiro, Dóra Lúðvíksdóttir, Andrew Menzies"Gow, Patrick Mitchell, Andriana Papaioannou, Todor A. Popov, Celeste Porsbjerg, Laila Salameh, Concetta Sirena, Camille Taillé, Christian Taube, Yuji Tohda, M.E. Wechsler, Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in severe asthma patients eligible for both, 2022Preprint, 2022, DOI
  • Michael Hartnett, Patrick Mitchell, An analysis of the effects of the leg-spacing on spectral response of offshore structures, Advances in Engineering Software, 31, (12), 2000, p991 - 998, p991-998Journal Article, 2000, DOI
  • Ilias E. Dimeas, George E. Zakynthinos, Christos Salmas, Ioannis Diamantis, Maria Giannaki, Charalampos Varsamas, Achilleas Sarris, Angeliki Miziou, Paraskevi Kirgou, Sotirios I. Sinis, Kathryn Duvall, Stavros P. Anastopoulos, Cormac McCarthy, Patrick D. Mitchell, Michael P. Keane, Maria Perraki, Evangelos Oikonomou, Ioannis D. Papanikolaou, Zoe Daniil, Microplastics in Human Thoracic Tissues: Increased Burden in Patients with Lung Malignancy, Journal of Clinical Medicine, 15, (17), 2026, p6503Journal Article, 2026, DOI
  • Maral Ranjbar, Christiane E. Whetstone, Ruth P. Cusack, Dhuha Al"Sajee, Hafsa Omer, Nadia Alsaji, Terence Ho, MyLinh Duong, Patrick Mitchell, Imran Satia, Paul K. Keith, Yanqing Xie, Jonathan MacLean, Doron D. Sommer, Paul M. O'Byrne, Roma Sehmi, Gail M. Gauvreau, Comparison of upper and lower airway expression of SARS"CoV"2 receptors in allergic asthma, Allergy, 79, (10), 2024, p2856-2858Journal Article, 2024, DOI
  • , Epithelial-Derived Cytokines in Asthma., Chest, 2017Journal Article, 2017
  • , Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017Journal Article, 2017
  • , Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma., Pharmacology & therapeutics, 2017Journal Article, 2017
  • , Anti-IgE and Biologic Approaches for the Treatment of Asthma., Handbook of experimental pharmacology, 2017Journal Article, 2017
  • , Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma., American journal of respiratory and critical care medicine, 2016Journal Article, 2016
  • , Surfactant Protein-D and Asthma., Chest, 2016Journal Article, 2016
  • , Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma., Clinical pharmacology and therapeutics, 2016Journal Article, 2016
  • , IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma., Respiratory research, 2016Journal Article, 2016
  • Gail Gauvreau, Roma Sehmi, J FitzGerald, Richard Leigh, Donald Cockcroft, Beth Davis, Irvin Mayers, Louis-Philippe Boulet, Brittany Salter, Ruth Cusack, Imran Satia, Kieran Killian, Patrick Mitchell, Viktoria Werkstrom, Tomasz Durzynski, Kathryn Shoemaker, Rohit Katial, Maria Jison, Paul Newbold, Paul O'Byrne, The effect of benralizumab on allergen-induced responses in subjects with mild allergic asthma, Journal of Allergy and Clinical Immunology, 147, (2), 2021, p157-Journal Article, URL

Research Expertise

  • Title
    Defining the impact of trained immunity in people with asthma: new target to reduce exacerbations and health costs associated with severe asthma
    Summary
    Date From
    August 2024
    Date To
    August 2027
  • Title
    Implication of the upper respiratory tract microbiota in long-COVID patients and the role of the new emerging beneficial bacterium Dolosigranulum pigrum.
    Summary
    COVID-19 is a new disease with high mortality caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and responsible for the ongoing global pandemic. Different studies performed over the past year demonstrated a link between COVID-19 severity and the nasopharynx microbiota, however, studies investigating changes in microbiome components with regards to the aftermath of the disease, such as full recovery or development of long-term COVID-19 symptoms are still lacking. This project aims to fill this knowledge gap by performing an in-depth characterization of microbial communities associated with the upper respiratory tract of patients that developed long-term COVID-19 symptoms and those who presented full recovery using metagenomics and state-of-art statistical analysis. In addition, the protective role of the bacterium Dolosigranulum pigrum against COVID-19 will also be investigated through genomics and immunoassay procedures. This proposal will advance our knowledge and help the scientific community by shedding light on the composition of the nasopharynx microbiota and its role in patients' recovery. By investigating the genetic features of a new emerging beneficial bacterium of the upper respiratory tract, we aim at elucidating its role for the host and probiotic potential against severe and long-term SARS-CoV-2 outcome.

Immunology, Clinical Medicine,

Recognition

  • The Asthma Society of Ireland and Irish Thoracic Society Joint Research Bursary 07/11/2015
  • Austine Mehigan Award for Teaching Excellence St Vincents University Hospital 6/2011
  • Member of the European Respiratory Society
  • Member of the Royal College of Physicians of Ireland
  • Member of the Association of Physicians of Great Britain and Ireland
  • Fellow of the Royal College of Physicians of Ireland
  • Member of the Irish Thoracic Society
  • Canadian Thoracic Society Asthma Guideline Committee 2021-2023
  • Medical Advisor Asthma Society of Ireland 01 July 2024
  • Chair, Research Fellows Committee Tallaght University Hospital (2021 to present, overseeing up to 4 fellows' research projects) 2025 ongoing
  • Invited reviewer of the following journals: Thorax BMJ Open Chest European Respiratory Journal PLOS One Journal of Thoracic Disease Respiratory Research 6/6/2016
  • Member, International Severe Asthma Registry (ISAR) group (2024"present) 2024 onwards
  • Medical Advisor, Asthma Society of Ireland (ongoing) 2025 ongoing
  • Medical adviser GSK RSV Vaccine role out Ireland 2024