Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

View the contact page for more contact and location information

medadmin@tcd.ie
Professor Sinead Brennan

Professor Sinead Brennan

Clinical Associate Professor, Radiation Therapy

Publications and Further Research Outputs

  • Clerkin C, Brennan S, Mullaney LM. , Establishment of national diagnostic reference levels (DRLs) for radiotherapy localisation computer tomography of the head and neck., Reports of Practical Oncology & Radiotherapy, 23, (5), 2018, p407 - 412Journal Article, 2018, DOI , URL
  • Mehanna H, Robinson M, Hartley A, Kong A, Foran B, Fulton-Lieuw T, Dalby M, Mistry P, Sen M, O'Toole L, Al Booz H, Dyker K, Moleron R, Whitaker S, De-ESCALaTE HPV Trial Group, Radiotherapy plus cisplatin or cetuximab in low-risk human papillomavirus-positive oropharyngeal cancer (De-ESCALaTE HPV): an open-label randomised controlled phase 3 trial., Lancet (London, England), 2018Journal Article, 2018, DOI , URL
  • Keenan LG, O'Sullivan S, Glynn A, Higgins M, Flavin A, Brennan S, Clinical review of treatment outcomes and patterns of failure with adjuvant radiotherapy in node-positive malignant melanoma., Journal of medical imaging and radiation oncology, 2016Journal Article, 2016, DOI
  • Fleming C, Cagney DN, O'Keeffe S, Brennan SM, Armstrong JG, McClean B, Normal tissue considerations and dose-volume constraints in the moderately hypofractionated treatment of non-small cell lung cancer., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016Journal Article, 2016, DOI
  • Rafee S, Elamin YY, Cronin K, Brennan S, Osman N, A rare case of nasopharyngeal carcinoma with widespread CNS metastases., Irish medical journal, 2014Journal Article, 2014, URL
  • Lin MY, Wu M, Brennan S, Campeau MP, Binns DS, MacManus M, Solomon B, Hicks RJ, Fisher RJ, Ball DL, Absence of a relationship between tumor ¹"F-fluorodeoxyglucose standardized uptake value and survival in patients treated with definitive radiotherapy for non-small-cell lung cancer., Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014Journal Article, 2014, URL
  • Gulliford SL, Miah AB, Brennan S, McQuaid D, Clark CH, Partridge M, Harrington KJ, Morden JP, Hall E, Nutting CM, Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT Phase III trial., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2012Journal Article, 2012, URL
  • Gregory DL, Brennan SM, Stillie A, Herschtal A, Hicks RJ, MacManus MP, Ball DL, Impact of 18F-fluorodeoxyglucose positron emission tomography in the staging and treatment response assessment of extra-pulmonary small-cell cancer., Journal of medical imaging and radiation oncology, 2010Journal Article, 2010, URL
  • Brennan S, Corry J, Kleid S, Porceddu S, Yuen K, Rischin D, Peters LJ, Prospective trial to evaluate staged neck dissection or elective neck radiotherapy in patients with CT-staged T1-2 N0 squamous cell carcinoma of the oral tongue., Head & neck, 2010Journal Article, 2010, URL
  • Brennan SM, Gregory DL, Stillie A, Herschtal A, Mac Manus M, Ball DL, Should extrapulmonary small cell cancer be managed like small cell lung cancer?, Cancer, 2010Journal Article, 2010, URL
  • Ahmed M, Schmidt M, Sohaib A, Kong C, Burke K, Richardson C, Usher M, Brennan S, Riddell A, Davies M, Newbold K, Harrington KJ, Nutting CM, The value of magnetic resonance imaging in target volume delineation of base of tongue tumours--a study using flexible surface coils., Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2010Journal Article, 2010, URL
  • Brennan SM, Thirion P, Buckney S, Shea CO, Armstrong J, Factors influencing conformity index in radiotherapy for non-small cell lung cancer., Medical dosimetry : official journal of the American Association of Medical Dosimetrists, 2009Journal Article, 2009, URL
  • Brennan S, Salib O, O'Shea C, Moriarty M, A randomized prospective study of extended tocopherol and pentoxifylline therapy, in addition to carbogen, in the treatment of radiation late effects., Ecancermedicalscience, 2008Journal Article, 2008
  • Agha A, Sherlock M, Brennan S, O'Connor SA, O'Sullivan E, Rogers B, Faul C, Rawluk D, Tormey W, Thompson CJ, Hypothalamic-pituitary dysfunction after irradiation of nonpituitary brain tumors in adults., The Journal of clinical endocrinology and metabolism, 2005Journal Article, 2005, URL
  • Agha A, Brennan S, Moore KB, Grogan L, Thompson CJ, Small-cell lung cancer presenting as diabetes insipidus and Cushing's syndrome., Pituitary, 2005Journal Article, 2005, URL
  • Glynn F, Brennan S, O'Leary G., CT staging and surveillance of the thorax in patients with newly diagnosed and recurrent squamous cell carcinoma of the head and neck: is it necessary?, Eur Arch Otorhinolaryngol, 263, (10), 2006, p943-945Journal Article, 2006, DOI
  • H Mehanna, A Kong, A Hartley, P Mistry, M Dalby, T Fulton-Lieuw, M Robinson, A Gray, B Foran, M Sen, L O'Toole, K Dyker, H Al Booz, R Moleron, S Brennan, E Aynsley, A Chan, D Srinivasan, J Buter, J Dunn, Cetuximab versus cisplatin in patients with HPV-positive, low risk oropharyngeal cancer, receiving radical radiotherapy, Annals of Oncology, 29, 2018, p729 - 730Journal Article, 2018
  • sinead brennan, Reply: Elective Radiotherapy or Neck Dissection for CT‐Staged T1-2N0 Oral Tongue Cancer, head neck, 30, 2010, p1430-Journal Article, 2010
  • Lang, P., Contreras, J., Kalman, N., Paterson, C., Bahig, H., Billfalk-Kelly, A., Brennan, S., Rock, K., Read, N., Venkatesan, V., Sathya, J., Mendez, L.C., MacNeil, S.D., Nichols, A.C., Fung, K., Mendez, A., Winquist, E., Kuruvilla, S., Stewart, P., Warner, A., Mitchell, S., Theurer, J.A., Palma, D.A., Preservation of swallowing in resected oral cavity squamous cell carcinoma: Examining radiation volume effects (PRESERVE): Study protocol for a randomized phase II trial, Radiation Oncology, 15, (1), 2020Journal Article, 2020
  • Brennan, S., Elective radiotherapy or neck dissection for CT-Staged T1-2N0 oral tongue cancer, Head and Neck, 32, (10), 2010, p1430Journal Article, 2010
  • Hintze, J and Lang, B and Subramaniam, T and Kruseman, N and O'Regan, E and Brennan, S and Lennon, P, Factors influencing nodal yield in neck dissections for head and neck malignancies, The Journal of laryngology and otology, 137, (8), 2023, p925â€"929Journal Article, 2023, DOI , URL
  • Ciaran Malone, Samantha Ryan, Jill Nicholson, Orla McArdle, Sinéad Brennan, P. McCavana, Brendan McClean, Fran Duane, Intrafraction Motion in Surface-Guided Breast Radiation Therapy and its Implications on a Single Planning Target Volume Margin Strategy, Practical Radiation Oncology, 15, (1), 2024, pe63 - e71, pe63-e71Journal Article, 2024, DOI
  • Niall O'Dwyer, Liam O'Connell, Darragh Browne, Bahareh Khosravi, Sinéad Brennan, Fran Duane, John Armstrong, Oleksandr Boychak, Orla McArdle, Treatment of oropharyngeal cancer during the COVID-19 lockdown " outcomes for patients treated during the pandemic, Reports of Practical Oncology & Radiotherapy, 29, (5), 2024, p606 - 613, p606-613Journal Article, 2024, DOI
  • Naseer, Amara and Brennan, Sinead and MacCarthy, Denise and O'Connell, John Edward and O'Sullivan, Eleanor and Leech, Michelle, Prevention of osteoradionecrosis in patients with head and neck cancer treated with radiation therapy, Head and Neck, 47, (2), 2025, p472 â€" 484Journal Article, 2025, DOI , URL
  • Frazer, Kate and Bhardwaj, Nancy and Fox, Patricia and Lyons, Ailsa and Syed, Shiraz and Niranjan, Vikram and McCann, Amanda and Kelly, Catherine and Brennan, Sinead and Brennan, Donal and Geraghty, James and Keane, Michael P. and Fitzpatrick, Patricia, A Qualitative Study to Understand the Barriers and Facilitators in Smoking Cessation Practices Among Oncology Health Care Practitioners in One Health System, Nicotine and Tobacco Research, 27, (2), 2025, p199 â€" 207Journal Article, 2025, DOI , URL
  • Malone, Ciaran and Ryan, Samantha and Nicholson, Jill and †Maolalai, Roisin O and O'Donovan, Rebecca and McArdle, Orla and Duane, Frances and Armstrong, John and Keenan, Lorna and Glynn, Aisling and Woods, Ruth and McClean, Brendan and Brennan, Sinead, Intrafraction motion stability of open vs. closed facemasks in head and neck radiotherapy: Insights from the OPEN phase III trial, Radiotherapy and Oncology, 209, 2025Journal Article, 2025, DOI , URL
  • Malone, Ciaran and Nicholson, Jill and Ryan, Samantha and Thirion, Pierre and Woods, Ruth and McBride, Peter and McArdle, Orla and Duane, Frances and Hanna, Gerard G. and McClean, Brendan and Brennan, Sinead, Real world AI-driven segmentation: Efficiency gains and workflow challenges in radiotherapy, Radiotherapy and Oncology, 209, 2025Journal Article, 2025, DOI , URL
  • Williamson, Andrew and Nankivell, Paul and Abou-Foul, Ahmad K. and Ahmed, Mohamed and Mehanna, Hisham and Nankivell, Paul and Mehanna, Hisham and Paleri, Vinidh and Williamson, Andrew and Holsinger, Chris and McDowell, Lachlan and Henson, Christina and Gomes, Ana and Parente, Pablo and Hardman, John and Patel, Snehal and Iyer, Gopal and Caroline, Kristunas and Abdul Rashid, Yasmin and Alpuim Costa, Diogo and Ando, Mizuo and Arthur, Charpentier and Bilic, Mario and Brennan, Sinead and Brunner, Markus and Caudell, Jimmy and Chow, Ling-Yu Velda and Danos, Kornel and DoleÅŸal, Pavel and Ferrari, Marco and Garas, Georgios and Laskar, Sarbani Ghosh and Guntinas-Lichius, Orlando and Hamid, Osama and Hamoir, Marc and Hodge, John-Charles and Hosal, Sefik and Hu, Chaosu and Kjaergaard, Thomas and Klozar, Jan and Kowalski, Luiz Paulo and Lauda Freitas Chaves, Aline and Leemans, René and Lim, Ida Marie and Matsuo, Jeanette Marie and McDowell, Lachlan and Ooi, Eng H and Pacheco-Ojeda, Luis and Psyrri, Amanda and Rodríguez, Argimiro and Rodríguez García, Roberto Antonio and Rueda Domínguez, Antonio and Saito, Yuki and Sattar, Abdus and Seikaly, Hadi and Serikbaiuly, Dulat and Stimpson, Paul and Subramaniam, Rathan M and Tao, Yungan and Torres-Holmes, Mark Nicolas and Tribius, Silke and Tseveensuren, Odontungalag and van den Brekel, Michiel and Vatanasapt, Patravoot and Wang, Cheng-Ping and Winter, Stuart, Trends in Investigations for Suspected Head and Neck Carcinoma of the Unknown Primary: A HNCIG and IFHNOS International Survey of Practice, Head and Neck, 47, (5), 2025, p1478 â€" 1486Journal Article, 2025, DOI , URL
  • Fox, Patricia and Bhardwaj, Nancy and Lyons, Ailsa and Niranjan, Vikram and Frazer, Kate and Syed, Shiraz and McCann, Amanda and Brennan, Sinead and Brennan, Donal and Kelly, Catherine and Keane, Michael and Fitzpatrick, Patricia, Smoking Cessation Support: A Marathon, Not a Sprint; The Perspectives of Cancer Patients Who Smoke, Seminars in Oncology Nursing, 40, (2), 2024Journal Article, 2024, DOI , URL
  • Glynn, Aisling M. and Harwood, Rachel and Garrett, Bill and Harper, Dean and Dunne, Mary and Nicholson, Jill and Rangaswamy, Guhan and Duane, Fran and Armstrong, John and McArdle, Orla and Brennan, Sinead, Unmasking anxiety: a head-to-head comparison of open and closed masks in head and neck cancer radiotherapy, Reports of Practical Oncology and Radiotherapy, 29, (2), 2024, p219 â€" 227Journal Article, 2024, DOI , URL
  • Baliga, Sujith and Abou-Foul, Ahmad K. and Parente, Pablo and Szturz, Petr and Thariat, Juliette and Shreenivas, Aditya and Nankivell, Paul and Bertolini, Federica and Biau, Julian and Blakaj, Dukagjin and Brennan, Sinead and Brunet, Aina and De Oliveira, Thiago Bueno and Burtness, Barbara and Maseda, Alberto Carral and Chow, Velda Ling-Yu and Chua, Melvin LK and de Ridder, Mischa and Garikipati, Satya and Hanai, Nobuhiro and Ho, Francis Cho Hao and Huang, Shao Hui and Kiyota, Naomi and Klinghammer, Konrad and Kowalski, Luiz P. and Kwong, Dora L and McDowell, Lachlan J and Merlano, Marco Carlo and Nair, Sudhir and Economopoulou, Panagiota and Overgaard, Jens and Psyrri, Amanda and Tribius, Silke and Waldron, John and Yom, Sue S. and Mehanna, Hisham, Essential data variables for a minimum dataset for head and neck cancer trials and clinical research: HNCIG consensus recommendations and database, European Journal of Cancer, 203, 2024Journal Article, 2024, DOI , URL
  • Nutting, Christopher and Finneran, Laura and Roe, Justin and Sydenham, Mark A and Beasley, Matthew and Bhide, Shree and Boon, Cheng and Cook, Audrey and De Winton, Emma and Emson, Marie and Foran, Bernadette and Frogley, Robert and Petkar, Imran and Pettit, Laura and Rooney, Keith and Roques, Tom and Srinivasan, Devraj and Tyler, Justine and Hall, Emma and Oliveros, S. and Lei, M. and Palaniappan, N. and Hwang, D. and Shanmugasundaram, R. and Cogill, G. and Wilson, C. and Brennan, S. and Christian, J. and Cole, N. and Macgregor, C., Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial, The Lancet Oncology, 24, (8), 2023, p868 â€" 880Journal Article, 2023, DOI , URL
  • Fitzpatrick, P. and Bhardwaj, N. and Masalkhi, M. and Lyons, A. and Frazer, K. and McCann, A. and Syed, S. and Niranjan, V. and Kelleher, C.C. and Brennan, S. and Kavanagh, P. and Fox, P., Provision of smoking cessation support for patients following a diagnosis of cancer in Ireland, Preventive Medicine Reports, 32, 2023Journal Article, 2023, DOI , URL
  • Gregory, D.L. and Brennan, S.M. and Stillie, A. and Herschtal, A. and Hicks, R.J. and MacManus, M.P. and Ball, D.L., Impact of 18F-fluorodeoxyglucose positron emission tomography in the staging and treatment response assessment of extra-pulmonary small-cell cancer: ORIGINAL ARTICLE, Journal of Medical Imaging and Radiation Oncology, 54, (2), 2010, p100 â€" 107Journal Article, 2010, DOI , URL
  • Osman N, Elamin YY, Rafee S, O'Brien C, Stassen LF, Timon C, Kinsella J, Brennan S, O'Byrne KJ., Weekly cisplatin concurrently with radiotherapy in head and neck squamous cell cancer: a retrospective analysis of a tertiary institute experience, Eur Arch Otorhinolaryngol, 271, (8), 2014, p2253-9Journal Article, 2014, DOI
  • Head and Neck Radiotherapy Long-Term Toxicity: The Role of Conformal Radiotherapy in, ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice March 2009, estro, 2009, [. Gillham C, Thirion P, Brennan S, Walsh L]Book Chapter
  • Prostate Cancer: Anatomy, Pathology and Treatment in, ESTRO Teaching Course on Radiotherapy Treatment Planning: Principles and Practice March 2009, 2006, [. Rangaswamy G, McVey G, Brennan S, Hacking D, Thirion P]Book Chapter

Recognition

  • Faculty of Radiologists RCSI/ Ipsen Travelling Fellowship, 2009 2009
  • Scholarship awarded to National Cancer Institute - - NCI Summer Fellowship Program in Cancer Prevention - Washington DC, July 2007 2007
  • Research presentation prize and educational bursary (ANZHNS 2008 Australia New Zealand Head Neck Society ASM) 2008
  • . National presentation prize and educational bursary (Faculty of Radiology RCSI Annual Meeting 2005) 2005
  • Irish Womens Awards 2019 - Contribution to Medicine January 2019
  • Title of College Scholar, University College Cork 1995 1995
  • Research presentation prize and educational bursary - British Thoracic Oncology Group 2008 January 2008
  • Cancer Trials Ireland member and Chair of Head Neck Cancer Disease Specific Subgroup ( DSSG) present
  • ASTRO - American Society of Therapeutic radiation Oncology
  • St Lukes Institute of Cancer Research - Board Member present
  • Faculty Of Radiology, Royal College of Surgeons in Ireland present
  • Royal college of physicians in Ireland membership
  • ESTRO European Society of Therapeutic Radiation Oncology
  • Head Neck Cancer Intergroup, Irish Representative present
  • Irish Cancer Society - Board Member present
  • Board Member Irish Cancer Society 08/2016
  • St Lukes Research Ethics Committee- Vice Chair 2018
  • St Lukes Insititute Cancer Research Board Member 2014
  • Member Cancer Prevention Committee Irish Cancer Society 2017
  • NCCP -national Cancer Control Program- Head Neck Cancer Clinical Lead 2017
  • Faculty of Radiology , Radiation Oncology Committee, Royal College of Surgeons in Ireland 2012