Genome

Genome Information

Title	Authors	Publication	Spec
An ENIGMA Consortium study of the relationship between white matter microstructure and positive and negative symptom severity in patients with schizophrenia.	Warren A, Holleran L, Agartz I, Andreassen OA, Banaj N, Cannon DM, Corvin A, Green M, Gur R, Hashimoto R, Hong E, Hoschl C, Kochunov P, Lawrie SM, McDonald C, Morris D, Mothersill D, Neilson E, Pantelis C, Piras F, Rasser PE, Roalf D, Satterthwaite TD, Schall U, Sim K, Skoch A, Spalletta G, Spaniel F, Thomopoulos S, Tomecek D, Zalesky A, Thompson PM, Jahanshad N, Turner JA, van Erp TGM, Donohoe G; ENIGMA Consortium Schizophrenia Working Group.	Schizophrenia (Heidelb). 2026	doi: 10.1038/s41537-026-00728-z. Online ahead of print.PMID: 41792186
The Psychiatric Genomics Consortium: discoveries and directions.	grawal A, Bulik CM, Abebe DS, Andreassen OA, Atkinson EG, Choi KW, Corvin A, Davies HL, Davis LK, Docherty AR, Edenberg HJ, Franke B, Gelernter J, Giusti-Rodríguez P, Hettema JM, Hjerling-Leffler J, Huang H, Johnson EC, Lewis CM, Lu Y, Lynall ME, Martin J, McIntosh AM, Montalvo-Ortiz JL, Mullins N, Nievergelt CM, O'Connell KS, O'Donovan MC, Okewole A, Peterson RE, Posthuma D, Sebat J, Smoller JW, Sud R, Viswanath B, Walters JTR, Won H, Wray NR, Sullivan PF; Coordinating Committee of the Psychiatric Genomics Consortium.	Lancet Psychiatry. 2025	doi: 10.1016/S2215-0366(25)00124-5. Epub 2025 Jun 26.PMID: 40582370 Review.
Fine-mapping genomic loci refines bipolar disorder risk genes.	Koromina M, Ravi A, Panagiotaropoulou G, Schilder BM, Humphrey J, Braun A, Bigdeli T, Chatzinakos C, Coombes BJ, Kim J, Liu X, Terao C, O'Connell KS, Adams MJ, Adolfsson R, Alda M, Alfredsson L, Andlauer TFM, Andreassen OA, Antoniou A, Baune BT, Bengesser S, Biernacka J, Boehnke M, Bosch R, Cairns MJ, Carr VJ, Casas M, Catts S, Cichon S, Corvin A, Craddock N, Dafnas K, Dalkner N, Dannlowski U, Degenhardt F, Di Florio A, Dikeos D, Fellendorf FT, Ferentinos P, Forstner AJ, Forty L, Frye M, Fullerton JM, Gawlik M, Gizer IR, Gordon-Smith K, Green MJ, Grigoroiu-Serbanescu M, Guzman-Parra J, Hahn T, Henskens F, Hillert J, Jablensky AV, Jones L, Jones I, Jonsson L, Kelsoe JR, Kircher T, Kirov G, Kittel-Schneider S, Kogevinas M, Landén M, Leboyer M, Lenger M, Lissowska J, Lochner C, Loughland C, MacIntyre DJ, Martin NG, Maratou E, Mathews CA, Mayoral F, McElroy SL, McGregor NW, McIntosh A, McQuillin A, Michie P, Mitchell PB, Moutsatsou P, Mowry B, Müller-Myhsok B, Myers RM, Nenadić I, Nievergelt CM, Nöthen MM, Nurnberger J, 'Donovan MO, 'Donovan CO, Ophoff RA, Owen MJ, Pantelis C, Pato C, Pato MT, Patrinos GP, Pawlak JM, Perlis RH, Porichi E, Posthuma D, Ramos-Quiroga JA, Reif A, Reiningh…	Nat Neurosci. 2025	doi: 10.1038/s41593-025-01998-z. Epub 2025 Jun 25.PMID: 40562893
Cognitive outcomes and performance of patients diagnosed and treated for N-Methyl-D-Aspartate receptor antibody-mediated (NMDAR) encephalitis compared with patients with schizophrenia and healthy controls.	Kelleher E, Mothersill D, Hargreaves A, Barry H, Smyth S, Chaila E, Boers P, McCabe DJ, Sweeney B, Costello D, Murphy KC, Cotter D, Doherty CP, Donohoe G, Corvin A.	Psychiatry Res Neuroimaging. 2025	doi: 10.1016/j.pscychresns.2025.111983. Epub 2025 Mar 17.
Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report.	Hill SY, Edenberg HJ, Corvin A, Thorgeirsson T, Below JE, Goldman D, Leal S, Almasy L, Cox NJ, Daly M, Neale B, Vrieze S, Zoghbi H.	Genes Brain Behav. 2025	doi: 10.1111/gbb.70017.PMID: 39935334
BICEP: Bayesian inference for rare genomic variant causality evaluation in pedigrees.	Ormond C, Ryan NM, Cap M, Byerley W, Corvin A, Heron EA.	Brief Bioinform. 2024	doi: 10.1093/bib/bbae624.PMID: 39656772
Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neuron development and mitochondrial function.	Ali D, Laighneach A, Corley E, Patlola SR, Mahoney R, Holleran L, McKernan DP, Kelly JP, Corvin AP, Hallahan B, McDonald C, Donohoe G, Morris DW.	PLoS Genet. 2024	doi: 10.1371/journal.pgen.1011093. eCollection 2024 Sep.PMID: 39259737
Investigating copy number variants in schizophrenia pedigrees using a new consensus pipeline called PECAN.	Ormond C, Ryan NM, Byerley W, Heron EA, Corvin A.	Sci Rep. 2024	doi: 10.1038/s41598-024-66021-0.PMID: 39080331
Whole genome sequencing study of identical twins discordant for psychosis.	Ormond C, Ryan NM, Hedman AM, Cannon TD, Sullivan PF, Gill M, Hultman C, Heron EA, Johansson V, Corvin A.	Transl Psychiatry. 2024	doi: 10.1038/s41398-024-02982-0.PMID: 39080272
Psychiatric genetics: what's new in 2015?	Corvin A, O'Donovan	MC Lancet Psychiatry, 2016	A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders.
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways.	Schizophrenia Working Group of the Psychiatric Genomics Consortium	Nature, 2014	In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings.
De novo mutations in schizophrenia implicate chromatin remodelling and support genetic overlap with ASD and ID	McCarthy et al.	Molecular Psychiatry, 2014	In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.
An inherited duplication at the gene P21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis	Morris DW et al.	Human Molecular Genetics, 2014	We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.
Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders	Kenny EM, et al.	Molecular Psychiatry, 2014	In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data.
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia	Irish Schizophrenia Genomics Consortium & WTCCC2	Biological Psychiatry, 2012	In a GWAS study of our cohort we provided further evidence for the role of MHC class I molecules in schizophrenia etiology.
Molecular pathways involved in neuronal cell adhesion and membrane scoffolding contribute to schizophrenia and bipolar disorder susceptibility	O'Dushlaine C, et al.	Molecular Psychiatry, 2011
Common polygenic variation contributes to risk in schizophrenia and bipolar disorder	O'Dushlaine C, et al.	Nature, 2009
Rare chromosomal deletions and duplications increase risk of schizophrenia	International Schizophrenia Consortium	Nature, 2008