Dr. Kate Connor

• Bo Lou, Kate Connor, Kieron Sweeney, Ian S Miller, Alice O'Farrell, Eduardo Ruiz-Hernandez, David M Murray, Garry P Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T Byrne, Wim E Hennink, RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells, Drug delivery and translational research, 9, (3), 2019, p679 - 693Journal Article, 2019
• Shields S, Conroy E, O'Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O'Connor D, McCann A, Gallagher WM, Coppinger JA., BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer., Oncotarget, 9, (21), 2018, p15673-15690Journal Article, 2018, DOI
• Kate Connor, Anna Golebiewska, Annette T. Byrne, Challenging the status quo to improve the translational potential of preclinical oncology studies, Nature Reviews Cancer, 25, (1), 2024, p3-4Journal Article, 2024
• Stéphanie I. De Vleeschauwer, Marieke van de Ven, Anaïs Oudin, Karlijn Debusschere, Kate Connor, Annette T. Byrne, Doreen Ram, Anne Marie Rhebergen, Yannick D. Raeves, Maik Dahlhoff, Virginie Dangles-Marie, Els R. Hermans, OBSERVE: guidelines for the refinement of rodent cancer models, Nature Protocols, 19, (9), 2024, p2571-2596Journal Article, 2024
• Brown KH, Kerr BN, Pettigrew M, Connor K, Miller IS, Shiels L, Connolly C, McGarry C, Byrne AT, Butterworth KT, A comparative analysis of preclinical computed tomography radiomics using cone-beam and micro-computed tomography scanners., Physics and imaging in radiation oncology, 2024Journal Article, 2024, DOI
• Kate Connor, Emer Conroy, Kieron White, Liam P. Shiels, Simon Keek, Abdalla Ibrahim, William M. Gallagher, Kieron J. Sweeney, James Clerkin, David O"Brien, Jane B. Cryan, Philip J. O"Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C. Woodruff, Annette T. Byrne, A clinically relevant computed tomography (CT) radiomics strategy for intracranial rodent brain tumour monitoring, Scientific Reports, 14, (1), 2024Journal Article, 2024
• Federica Fabro, Trisha V. Kers, Kate J. Feller, Cecile Beerens, Ioannis Ntafoulis, Ahmed Idbaih, Maite Verreault, Kate Connor, Archita Biswas, Manuela Salvucci, Jochen H. M. Prehn, Annette T. Byrne, Alice C. O"Farrell, Diether Lambrechts, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Andreas Kremer, Romain Tching Chi Yen, Miao-Ping Chien, Martine L. M. Lamfers, Sieger Leenstra, Genomic Exploration of Distinct Molecular Phenotypes Steering Temozolomide Resistance Development in Patient-Derived Glioblastoma Cells, International Journal of Molecular Sciences, 24, (21), 2023, p15678Journal Article, 2023
• Gareth Morris, Massimo Avoli, Christophe Bernard, Kate Connor, Marco de Curtis, Chris G. Dulla, John G. R. Jefferys, Caterina Psarropoulou, Kevin J. Staley, Mark O. Cunningham, Can in vitro studies aid in the development and use of antiseizure therapies? A report of the ILAE/AES Joint Translational Task Force, Epilepsia, 64, (10), 2023, p2571-2585Journal Article, 2023
• Ioannis Ntafoulis, Anne Kleijn, Jie Ju, Kevin Jimenez-Cowell, Federica Fabro, Michelle Klein, Romain Tching Chi Yen, Rutger K. Balvers, Yunlei Li, Andrew P. Stubbs, Trisha V. Kers, Johan M. Kros, Sean E. Lawler, Laurens V. Beerepoot, Andreas Kremer, Ahmed Idbaih, Maite Verreault, Annette Byrne, Alice C. O"Farrell, Kate Connor, Archita Biswas, Manuela Salvucci, Jochen H. M. Prehn, Diether Lambrechts, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Martin van den Bent, Clemens M. F. Dirven, Sieger Leenstra, Franck Bielle, Emie Quissac, Jane Cryan, Francesca Brett, Alan Beausang, Orna Bacon, Steve MacNally, Philip O"Halloran, James Clerkin, Martine Lamfers, GLIOTRAIN consortium, Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers, British Journal of Cancer, 2023Journal Article, 2023, DOI
• Archita Biswas, Manuela Salvucci, Kate Connor, Heiko Düssmann, Steven Carberry, Michael Fichtner, Ellen King, Brona Murphy, Alice C. O"Farrell, Jane Cryan, Alan Beausang, Josephine Heffernan, Mattia Cremona, Bryan T. Hennessy, James Clerkin, Kieron J. Sweeney, Steve MacNally, Francesca Brett, Philip O"Halloran, Orna Bacon, Simon Furney, Maite Verreault, Emie Quissac, Franck Bielle, Mohammed H. Ahmed, Ahmed Idbaih, Sieger Leenstra, Ioannis Ntafoulis, Federica Fabro, Martine Lamfers, Anna Golebiewska, Frank Hertel, Simone P. Niclou, Romain Tching Chi Yen, Andreas Kremer, Gonca Dilcan, Francesca Lodi, Ingrid Arijs, Diether Lambrechts, Manasa Kalya Purushothama, Alexander Kel, Annette T. Byrne, Jochen H.M. Prehn, Comparative analysis of deeply phenotyped GBM cohorts of `short-term" and `long-term" survivors, Journal of Neuro-Oncology, 163, (2), 2023, p327--338Journal Article, 2023, DOI
• K. White, K. Connor, M. Meylan, A. Bougoüin, M. Salvucci, F. Bielle, A.C. O"Farrell, K. Sweeney, L. Weng, G. Bergers, P. Dicker, D.M. Ashley, E.S. Lipp, J.T. Low, J. Zhao, P. Wen, R. Prins, M. Verreault, A. Idbaih, A. Biswas, J.H.M. Prehn, D. Lambrechts, I. Arijs, F. Lodi, G. Dilcan, M. Lamfers, S. Leenstra, F. Fabro, I. Ntafoulis, J.M. Kros, J. Cryan, F. Brett, E. Quissac, A. Beausang, S. MacNally, P. O"Halloran, J. Clerkin, O. Bacon, A. Kremer, R.T. Chi Yen, F.S. Varn, R.G.W. Verhaak, C. Sautès-Fridman, W.H. Fridman, A.T. Byrne, Identification, validation and biological characterisation of novel glioblastoma tumour microenvironment subtypes: implications for precision immunotherapy, Annals of Oncology, 34, (3), 2023, p300--314Journal Article, 2023, DOI
• Ian Miller, Sonja Khan, Liam P. Shiels, Sudipto Das, Alice C. O' Farrell, Kate Connor, Adam Lafferty, Bruce Moran, Claudio Isella, Paul Loadman, Emer Conroy, Susan Cohrs, Roger Schibli, Robert S. Kerbel, William M. Gallagher, Elisabetta Marangoni, Kathleen Bennett, Darran P. O' Connor, Roisin Dwyer, Annette T. Byrne, Implementing subtype"specific pre"clinical models of breast cancer to study pre"treatment aspirin effects, Cancer Medicine, 11, (20), 2022, p3820--3836Journal Article, 2022, DOI
• Oluwakanyinsolami Netufo, Kate Connor, Liam P. Shiels, Kieron J. Sweeney, Dan Wu, Donal F. O"Shea, Annette T. Byrne, Ian S. Miller, Refining Glioblastoma Surgery through the Use of Intra-Operative Fluorescence Imaging Agents, Pharmaceuticals, 15, (5), 2022, p550Journal Article, 2022
• Kate Connor, David W. Murray, Monika A. Jarzabek, Nhan L. Tran, Kieron White, Patrick Dicker, Kieron J. Sweeney, Philip J. O"Halloran, Brian MacCarthy, Liam P. Shiels, Francesca Lodi, Diether Lambrechts, Jann N. Sarkaria, Raymond M. Schiffelers, Marc Symons, Annette T. Byrne, Targeting the RhoGEF ßPIX/COOL-1 in Glioblastoma: Proof of Concept Studies, Cancers, 12, (12), 2020, p3531Journal Article, 2020
• Alice C. O"Farrell, Monika A. Jarzabek, Andreas U. Lindner, Steven Carberry, Emer Conroy, Ian S. Miller, Kate Connor, Liam Shiels, Eugenia R. Zanella, Federico Lucantoni, Adam Lafferty, Kieron White, Mariangela Meyer Villamandos, Patrick Dicker, William M. Gallagher, Simon A. Keek, Sebastian Sanduleanu, Philippe Lambin, Henry C. Woodruff, Andrea Bertotti, Livio Trusolino, Annette T. Byrne, Jochen H. M. Prehn, Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models, Cancers, 12, (10), 2020, p2978Journal Article, 2020, DOI
• White, K., Connor, K., Clerkin, J., Murphy, B.M., Salvucci, M., O'Farrell, A.C., Rehm, M., O'Brien, D., Prehn, J.H.M., Niclou, S.P., Lamfers, M.L.M., Verreault, M., Idbaih, A., Verhaak, R., Golebiewska, A., Byrne, A.T., New hints towards a precision medicine strategy for IDH wild-type Glioblastoma, Annals of Oncology, 31, (12), 2020, p1679-1692Journal Article, 2020
• Dienstmann, R., Connor, K., Byrne, A.T., Precision Therapy in RAS Mutant Colorectal Cancer, Gastroenterology, 158, (4), 2020, p806-811Journal Article, 2020
• Miller, Ian S., Shiels, Liam P., Conroy, Emer, Connor, Kate, Dicker, Patrick, Gallagher, William M., Donovan, Norma O", Kerbel, Robert S., Crown, John, Byrne, Annette T., Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents, Scientific Reports, 9, (1), 2019Journal Article, 2019
• Moran, Bruce, Das, Sudipto, Smeets, Dominiek, Peutman, Gillian, Klinger, Rut, Fender, Bozena, Connor, Kate, Ebert, Matthias, Gaiser, Timo, Prehn, Jochen HM, Bacon, Orna, Kay, Elaine, Hennessy, Bryan, Murphy, Verena, Ylstra, Bauke, Lambrechts, Diether, Byrne, Annette T., Gallagher, William M., O"Connor, Darran P., Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach, Oncotarget, 8, (29), 2017, p48126-48137Journal Article, 2017
• Das, Sudipto, Kelly, Deirdre, Moran, Bruce, Han, Kathleen, Mulligan, Niall, Barrett, Ciara, Buckley, Patrick G., McMahon, Peter, McCaffrey, John, Van Essen, Hendrik F., Connor, Kate, Lambrechts, Diether, Ylstra, Bauke, Gallagher, William M., O"Connor, Darran P., Kelly, Catherine M., Postmortem Examination of an Aggressive Case of Medullary Thyroid Carcinoma Characterized by Catastrophic Genomic Abnormalities, JCO Precision Oncology, (1), 2017, p1-7Journal Article, 2017
• Connor, Kate, Jarzabek, Monika A., White, Kieron, Jacobs, Andreas H., Byrne, Annette T., Imaging Targeted Therapy Response and Resistance in Glioblastoma, Resistance to Targeted Anti-Cancer Therapeutics, 2016, p175-198Book Chapter, 2016
• O'Leary, P.C., Terrile, M., Bajor, M., Gaj, P., Hennessy, B.T., Mills, G.B., Zagozdzon, A., O'Connor, D.P., Brennan, D.J., Connor, K., Li, J., Gonzalez-Angulo, A.M., Sun, H.-D., Pu, J.-X., Ponte"n, F., Uhle"n, M., Jirstro"m, K., Nowis, D.A., Crown, J.P., Zagozdzon, R., Gallagher, W.M., Peroxiredoxin-1 protects estrogen receptor " from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer, Breast Cancer Research, 16, (4), 2014Journal Article, 2014
• Laura A. Smith, Ella B. Keane, Kate Connor, Felix Chan, Mark O. Cunningham, In vitro modelling of the neuropathophysiological features of mitochondrial epilepsy, Seizure, 2025Journal Article, 2025

• Mark Cunningham, Kate Connor, Innovative gene therapy approaches for brain tumour-related epilepsy, Open Access Government, 40, (1), 2023, p98-99Journal Article

I specialise in the study of difficult-to-treat malignancies with unmet clinical needs. My research focuses on four key areas: a) the development of advanced preclinical models of glioblastoma (GBM) and brain tumour related epilepsy; b) interrogation of tumour microenvironment contexts of vulnerability; c) investigation of mechanisms of response to immunotherapy; and d) the use of CT and MR radiomics for the interrogation of disease progression and therapeutic response both pre-clinically and clinically.

• Title

  3D bioprinting as a refined approach to interrogating cellular mechanisms, pharmacology and electrophysiology
  Summary
  Funding Agency

  Stream 1 HEREG
  Date From

  11/01/2025
  Date To

  21/12/2026

Predictive and prognostic markers, Cancer, Pharmacology and pharmaceutical sciences, Molecular targets, Cancer therapy (excl. chemotherapy and radiation therapy), Neurosciences,

• Cancer Trials Ireland (CTI) Present
• Society for Neuro-Oncology (SNO) member Present
• World molecular imaging society (WMIS) Present
• European Association of Cancer Research (EACR) Present
• Irish Association of Cancer Research (IACR) Present