COOLPRIME - Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy

COOLPRIME (Comparative Effectiveness for Cooling Prospectively Infants with Mild Encephalopathy) is an observational study that will observe the effects of therapeutic hypothermia (TH) vs normothermia (NT) in infants with mild hypoxic ischemic encephalopathy (HIE). The choice of therapy will be based on each clinical site’s existing practice.

COOLPRIME forms part of the international ELEVATE project. ELEVATE aims to predict, detect, and intervene early in neonates who are at the highest risk of developing cerebral palsy. The goal is to improve outcomes through timely and targeted care.

Babies who fit the criteria for COOLPRIME will be followed up for two years to assess cognitive, language, and motor outcomes, helping define and improve future care standards.

Further details about our research projects are available at our COOLPRIME Website.

Funder

Cerebral Palsy Foundation, SFI

Research Team & Collaborators

Prof Eleanor Molloy (PI), Dr. Nicoleta Barbu (Research Fellow), Aoife Moran (Research Nurse), Dr. Sara Hope Kift (Clinical Specialist Neonatal Occupational Therapist), Dr John Kelleher.