Dr. Mary O'Sullivan

• Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449Journal Article, 2016, DOI , URL , TARA - Full Text
• Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379Journal Article, 2016, URL , TARA - Full Text
• O'Sullivan, M. P., O'Leary, S., Prentice, M. B., Keane, J., Macrophage Responses to a Clinical Isolate of Mycobacterium tuberculosis, Irish Journal of Medical Science, 180, 2011, pS444Journal Article, 2011
• Lawlor, C., O'Sullivan, M., O'Leary, S., Bowie, R., Keane, J., Gallagher, P. J., Cryan, S. A., A study of the interaction of novel, coated microparticles with alveolar macrophages and their application in tuberculosis treatment via inhalation, Drug Discovery Today, 15, (23-24), 2010, p1107Journal Article, 2010
• O'Sullivan, M. P., Ryan, R., O'Leary, S., Keane, J., Human Macrophages Infected with Mycobacterium tuberculosis Undergo a Non-Apoptotic Form of Cell Death., American Journal of Respiratory and Critical Care Medicine, 179, 2009Journal Article, 2009
• Daniel J. Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie H. Abildgaard, Yakubu Princely Abudu, [...], Mary P. O'Sullivan, Timothy E. O'Sullivan, [...], Judith C. Sluimer, Christina L. Stallings & Chun-Kit Tong, Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, 17, (1), 2021, p1 - 382Journal Article, 2021, DOI , URL
• Bahlool AZ, Cavanagh B, Sullivan AO, MacLoughlin R, Keane J, O'Sullivan MP, Cryan SA., Microfluidics produced ATRA-loaded PLGA NPs reduced tuberculosis burden in alveolar epithelial cells and enabled high delivered dose under simulated human breathing pattern in 3D printed head models., European Journal of Pharmaceutical Sciences : official journal of the European Federation for Pharmaceutical Sciences, 2024, p106734Journal Article, 2024, DOI
• Brown K, Walsh A, Yennemadi A, O'Leary S, O'Sullivan M, Nadarajan P, Basdeo S, Leisching G, Keane J, Mycobacterium tuberculosis Induces Warburg Metabolism in Human Alveolar Macrophages: A Transcriptomic Analysis., American Journal of Respiratory Cell and Molecular Biology, 2025Journal Article, 2025, DOI
• Conor Grant, Emily Duffin, Finbarr O'Connell, Parthiban Nadarajan, Colm Bergin, Joseph Keane, Mary P. O'Sullivan, Human Alveolar Macrophages Detect SARS-CoV-2 Envelope Protein Through TLR2 and TLR4 and Secrete Cytokines in Response, Immunology, 2025Journal Article, 2025, DOI
• Conor Grant, Colm Bergin, Joseph Keane, Mary P. O'Sullivan, All Trans Retinoic Acid as a Host-directed Therapy for Nontuberculous Mycobacteria, American Thoracic Society, 2024, ppA6273-Conference Paper, 2024, DOI
• Mary P. O'Sullivan, Denise Triglia Van Nierop, Karl M Gogan, Joseph Keane, Immunometabolism Directs Human CD1c-Positive Myeloid Dendritic Cell Responses to BCG Infection, American Thoracic Society, 2019, ppA4237 - A4237, ppA4237-A4237Conference Paper, 2019, DOI
• Kate Mc Quaid, Joseph Keane, Hardy Kornfeld, Mary P. O'Sullivan, Seónadh M. O'Leary, Pharmacological modulation of the autophagy pathway enhances Mtb killing, Access Microbiology, 2, (1), 2020Journal Article, 2020, DOI
• Tyner, JW, Uchida, O, Kajiwara, N, Kim, EY, Patel, AC, O'Sullivan, MP, Walter, MJ, Schwendener, RA, Cook, DN, Danoff, TM, Holtzman, MJ, CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection., Nature Medicine, 11, (11), 2005, p1180 - 1187Journal Article, 2005, DOI
• O'Sullivan, MP, Tyner, JW, Holtzman, MJ, Apoptosis in the airways: another balancing act in the epithelial program., American Journal of Respiratory Cell and Molecular Biology, 29, (1), 2003, p3 - 7Journal Article, 2003, DOI
• Holtzman, MJ, Morton, JD, Shornick, LP, Tyner, JW, O'Sullivan, MP, Antao, A, Lo, M, Castro, M, Walter, MJ, Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm., Physiological Reviews, 82, (1), 2002Journal Article, 2002, DOI
• Jayaraman, S, Castro, M, O'Sullivan, M, Bragdon, MJ, Holtzman, MJ, Resistance to Fas-mediated T cell apoptosis in asthma., Journal of Immunology (Baltimore, Md. : 1950), 162, (3), 1999Journal Article, 1999
• Zhang, V, O'Sullivan, M, Hussain, H, Roswit, WT, Holtzman, MJ, Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2., Biochemical and Biophysical Research Communications, 227, (2), 1996Journal Article, 1996, DOI
• Mercedes González-Juarrero, and Mary P. O'Sullivan, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells, Tuberculosis, 91, (1), 2011, p86-92Journal Article, 2011, DOI , URL , TARA - Full Text
• González-Juarrero M, O'Sullivan MP, Optimization of inhaled therapies for tuberculosis: The role of macrophages and dendritic cells., Tuberculosis (Edinburgh, Scotland), 91, (1), 2010, p86 - 92Journal Article, 2010, DOI
• O'Leary S, O'Sullivan MP, Keane J., IL-10 Blocks Phagosome Maturation in Mycobacterium tuberculosis-infected Human Macrophages., American Journal of Respiratory Cell and Molecular Biology, 45, (1), 2011, p172 - 180Journal Article, 2011
• Lawlor C, O'Sullivan MP, Sivadas N, O'Leary S, Gallagher PJ, Keane J, Cryan SA, The Application of High-Content Analysis in the Study of Targeted Particulate Delivery Systems for Intracellular Drug Delivery to Alveolar Macrophages., Molecular Pharmaceutics, 8, (4), 2011, p1100 - 1112Journal Article, 2011, DOI
• O'Leary, S.M., O'Sullivan M.P., Keane, J., IL-10 blocks phagosome maturation in human macrophages infected with M. tuberculosis, American Journal of Cell and Molecular Biology, 2010Journal Article, 2010
• O'Sullivan M, Clancy JM, Roche JF, Corrigan OI, Controlled delivery of oestradiol-17-b from silastic implants: in vitro and in vivo evaluation., European Journal of Drug Metabolism and Pharmacokinetics, Spec No 3, 1991, p478-82Journal Article, 1991
• Verma NK, Conroy J, Lyons PE, Coleman J, O'Sullivan MP, Kornfeld H, Kelleher D, Volkov Y, Autophagy induction by silver nanowires: A new aspect in the biocompatibility assessment of nanocomposite thin films., Toxicology and Applied Pharmacology, 264, (3), 2012, p451-61Journal Article, 2012, DOI

• Regulation of epithelial-leukocyte interaction and epithelial immune-response genes in, Asthma and Rhinitis, Cambridge, MA, Blackwell Scientific, 2000, pp784 - 800, [MJ Holtzman, M Castro, DC Look, M O'Sullivan, MJ Walter]Book Chapter

• Title

  Leveraging autophagy to direct an inhales TB vaccine to dendritic cell autophagosomes for better antigen presentation
  Summary
  Funding Agency

  Dean's Research Initiatives Research Fund
  Date From

  2016
  Date To

  2017
• Title

  Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
  Summary
  Funding Agency

  TTMI BEHR funding
• Title

  Development of inhaled medicines for treatment of Tuberculosis
  Summary
  Funding Agency

  HRB
  Date From

  2012
  Date To

  2016
• Title

  Particle engineering to target interferon-gamma to alveolar macrophages for the adjunct treatment of multi-drug resistant tuberculosis
  Summary
  Funding Agency

  HRB
  Date From

  2007
  Date To

  2011
• Title

  Immunometabolic manipulation of pulmonary immunity - towards TB host directed therapy
  Summary
  Funding Agency

  HRB
  Date From

  2019
• Title

  Correcting Pulmonary Immunity through manipulation of CFTR
  Summary
  Funding Agency

  HRCI/HRB
  Date From

  2021
  Date To

  2023
• Title

  Defining the role of human dendritic cell subsets in host immune responses to mycobacterial infection.
  Summary
  Funding Agency

  HRB
  Date From

  2013
  Date To

  31-12-2017
• Title

  The mechanism of macrophage cell death in response to M. tuberculosis infection and its role in the fate of mycobacteria
  Summary
  Funding Agency

  SFI
  Date From

  2008
  Date To

  2012
• Title

  Investigation of the fungicidal activity of macrophages against the fungal pathogen Aspergillus fumigatus with an automated live cell imaging microscope.
  Summary
  Funding Agency

  Trinity Translational Medicine Institute Bursary
• Title

  Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
  Summary
  Funding Agency

  Health Research Board/ Irish Thoracic Society
  Date From

  1-1-2017
  Date To

  31-12-2018

Immunology, Medical and biomedical engineering, Biochemistry and cell biology,

• Dean's Research Initiatives Research Fund Bursary February 2016
• American Thoracic Society Travel Award 2007
• Irish Thoracic Society Award for Best Oral Presentation 2008

• American Thoracic Society
• American Association for the Advancement of Science Present

• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, PHG Funded PI's and Researchers, All Researchers funded under Cycle 3 PRTLI - Programme for Human Genomics
• Member, Imaging Focus Group Meeting, 1-Day meeting on Biomedical Imaging - 8th June 2004 run in conjunction with TCINFrom single cell & molecular through to organ & whole bodyLast Revised : 22 May 2004