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Papers from the Nanomechanics Team

Google Scholar: Martin Hegner


Brunetti, G., De Pastina, A. and Hegner, M. (2021) Quantitative epitope analysis reveals drastic 63% reduced immuno-affinity and 60% enhanced transmissibility for SARS-CoV-2 variants. Nanoscale Advances 3, 6903–6911; DOI: 10.1039/d1na00554e
Direct label-free analysis of SARS-CoV2 variants side by side.
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Brunetti, G., De Pastina, A. and Hegner, M. (2021) Rapid Label-free Nanotechnological Immunoassay for Analysis of Candidate Malaria Vaccines. Appl. Cell Biol. 9 (2) 29-32 DOI: 10.53043/2320-1991.acb90006
Commentary to Brunetti et al Nanoscale 2021 (Nanotechnological immunoassay ...).
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De Pastina, A., Padovani, F., Brunetti, G., Rotella, C., Niosi, F., Usov. V. and Hegner, M. (2021) Multimodal real-time frequency tracking of cantilever arrays in liquid environment for biodetection: Comprehensive setup and performance analysis. Review of Scientific Instruments 92, 065001, DOI: 10.1063/5.0047631
Multi PLL tracking of higher mode cantilever arrays with 18 sensors in fluids.
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Brunetti, G., Padovani, F., De Pastina, A., Rotella,C., Monahan, A., Hoffman, S., Jongo, S., Abdulla, S., Corradin, G., Pluschke, G., Daubenberger, C. and Hegner, M. (2021) Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines. Nanoscale 13, 2338 - 2349 DOI: 10.1039/D0NR08083G
Quick, quantitative label-free diagnostics of malaria vaccine candidates.
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Padovani, F. and Hegner, M. (2019) Novel strategies for clinical coagulation diagnostics and therapy monitoring Clin. Lab. Int 43, 20-22
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Duffy, J., Padovani, F., Brunetti, G., Noy, P., Certa, U., Hegner, M. (2018) Towards personalised rapid label free miRNA detection for cancer and liver injury diagnostics in cell lysates and blood based samples Nanoscale 10, 12797-12804; doi: 10.1039/c8nr03604g
Novel strategy for quick, reliable and quantitative diagnostics of expression patterns of non-coding short RNA in blood plasma or cell cultures
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Li-Qing Zheng, L., Wang, X., Shao, F., Hegner, M., Zenobi, R. (2018) Nanoscale Chemical Imaging of Reversible Photoisomerization of an Azobenzene-Thiol Self-Assembled Monolayer by Tip-Enhanced Raman Spectroscopy Angew. Chem. Intl. Ed. 57, 1025-1029; doi:10.1002/anie.201710443
Switchin’ on the edge: The reversible photoisomerization of an azobenzene thiol (ABT) self-assembled monolayer was demonstrated by tip-enhanced Raman spectroscopy with nanoscale spatial resolution
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Padovani, F., Duffy, J., Hegner, M. (2017) Nanomechanical clinical coagulation diagnostics and monitoring of therapies Nanoscale 9, 17939 - 17947; doi:10.1039/C7NR06992H
Nano-oscillations of microcantilevers as a novel strategy to diagnose and monitor blood coagulation disorders, using a few microliters of the sample
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Wruck, F., Katranidis, A., Nierhaus, K.H., Büldt, G., Hegner, M. (2017) Translation and folding of single proteins in real-time Proc. Natl. Acad. Sci. USA 114 (22) E4399-E4407; doi:10.1073/pnas.1617873114
Study that elucidates the intricate relationship between a protein’s amino acid sequence, its cotranslational nascent chain elongation rate and folding
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Padovani, F., Duffy, J., Hegner, M. (2017) Microrheological Coagulation Assay Exploiting Micromechanical Resonators Analytical Chemistry 89 (1), 751 - 758; doi:10.1021/acs.analchem.6b03347
Microrheologial Clinical Assay for Blood Anomalies
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Jadhav, V.S., Brüggemann, D., Wruck, F., Hegner, M. (2016) Single-molecule mechanics of protein-labelled DNA handles Beilstein J. Nanotechnol. 7, 138–148. DOI:10.3762/bjnano.7.16
Modified DNA handles for single molecule experiments
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Sinead Winters, Nina C. Berner, Rohit Mishra, Kim C. Dumbgen,Claudia Backes, Martin Hegner, Andreas Hirsch and Georg S. Duesberg (2015) On-surface derivatisation of aromatic molecules on graphene: the importance of packing density ChemComm 51, 16778, DOI: 10.1039/c5cc06433c
Chemical functionalisation of graphene interfaces
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Walther, M.,Fleming, P.M., Padovani, F., Hegner, M. (2015) An optimized measurement chamber for cantilever array measurements in liquid incorporating an automated sample handling system EPJ Techniques and Instrumentation 2:7, DOI 10.1140/epjti/s40485-015-0017-7 Movie of liquid exchange in cantilever array measurement chamber
A detailed description of our latest analytical cantilever array sensing device. Fluidics, differential read-out and sample analysis
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Maloney, N., Lukacs, G., Jensen, J. Hegner, M. (2014) Nanomechanical Sensors for Single microbial cell growth monitoring Nanoscale 6, 8242-8249, DOI: 10.1039/C4NR01610F
Mechanical testing of single cells in real-time
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Mishra, R., Hegner, M. (2014) Effect of non-specific species competition from total RNA on the static mode hybridization response of nanomechanical assays of oligonucleotides Nanotechnology 25, 225501 doi: 10.1088/0957-4484/25/22/225501
Detecting short nucleic acids in a coplex total RNA background
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Maloney, N., Lukacs, G., Ball,S. L., Hegner, M. (2014) Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers Rev. Sci. Instrum. 85, 015003;
Growth monitoring of microfungi on nanomechanical sensors
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Jensen, J., Maloney, N., Hegner, M. (2013) A multi-mode platform for cantilever arrays operated in liquid Sensors and Actuators B: Chemical 183, 388–394 doi: 10.1016/j.snb.2013.03.133
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Hegner, M., Bruggemann, D., Skoko, D. (2012) Optical Tweezers, Encyclopedia of Nanotechnology, Bhushan, Bharat (Ed.), Springer, ISBN 978-90-481-9750-7, pages 1981 - 1991.
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Lukacs, G. Maloney, N. and Hegner, M. (2012) Ink-Jet Printing: Perfect Tool for Cantilever Array Sensor Preparation for Microbial Growth Detection Journal of Sensors Vol 2012, Article ID 561256, 7 pages doi:10.1155/2012/561256.
Automation of cantilever functionalization with cells
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Daly, R., Kumar, S., Lukacs, G., Lee, K., Weidlich, A., Hegner, M., Duesberg, G.S. (2012) Cell Proliferation Tracking Using Graphene Sensor Arrays Journal of Sensors, Article ID 219485, 7 pages doi:10.1155/2012/219485.
Graphene arrays for bioanalytical analysis
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Noy, P., Steiner, R., Voelkle, J., Hegner, M. and Fattinger, Ch. (2012) Instrument for Label-Free Detection of Noncoding RNAs Journal of Sensors, Article ID 208079, 5 pages
Continous flow nanomechanical measurements in Industry
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Jensen, J., Farina, M., Zuccheri, G., Grange, W. and Hegner, M. (2012) Quantitative, Label-Free Detection of the Aggregation of α-Synuclein Using Microcantilever Arrays Operated in a Liquid Environment Journal of Sensors Vol. 2012 (2012), Article ID 874086, 7 pages doi:10.1155/2012/874086.
Protein aggregation as a cause for neurodegenerative diseases
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Mishra, R., Grange, W. and Hegner, M. (2012) Rapid and Reliable Calibration of Laser Beam Deflection System for Microcantilever-Based Sensor Setups Journal of Sensors
Vol. 2012 Article ID 617386, 6 pages, doi:10.1155/2012/617386.
Geometrical differences require precise calibration of individual devices
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Maloney, N., Lukacs, G., Nugaeva, N., Grange, W., Ramseyer, J. P., Jensen, J., Hegner, M. (2012) Fibre Optic Readout of Microcantilever Arrays for Fast Microorganism Growth Detection," J. of Sensors, vol. 2012, Article ID 405281, 6 pages. doi:10.1155/2012/405281.
Rapid microfungus growth analyis using nanomechanical sensors
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Jensen, J. and Hegner, M. (2012) Predictions of the Compressible Fluid Model and its Comparison to Experimental Measurements of Q Factors and Flexural Resonance Frequencies for Microcantilevers J. of Sensors, vol. 2012, Article ID 258381, 7 pages. doi:10.1155/2012/258381.
Inverse behaviour of Quality factors observed in higher modes in the gas phase
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  • Park, K. K., Lee, H., Kupnik, M., Oralkan, O., Ramseyer, J. P., Lang, H. P., Hegner, M., Gerber, C., Khuri-Yakub, B. T. (2011) Capacitive micromachined ultrasonic transducer (CMUT) as a chemical sensor for DMMP detection Sensors and Actuators B-Chemical 160, 1120-1127. doi: 10.1016/j.snb.2011.09.036
    Chemical sensing at the limit of 56 ppb of DMMP (Sarin alanog) by CMUT chemical sensor
  • Katranidis, A., Grange, W., Schlesinger, R.,Choli-Papadopoulou, T., Bruggemann, D., Hegner, M., Buldt, G. (2011) Force measurements of the disruption of the nascent polypeptide chain from the ribosome by optical tweezers FEBS Letters, 585, 1859–1863.doi: 10.1016/j.febslet.2011.04.045
    pdf, supplemental video
    Using optical forces the molecular strength of the nascent polypeptide chain anchored in the ribosome machinery are determined


    Springer Handbook of Nanotechnology. Chapter: 'Nanomechanical Cantilever Array Sensors' Hans Peter Lang, Martin Hegner, Christoph Gerber Pages 427-452; ISBN: 978-3-642-02524-2 (Print) pdf

    Haas, P.,Then, P., Wild, A., Grange, W., Zorman, S., Hegner, M., Calame, M., Aebi, U., Flammer, J., Hecht, B. (2010) Fast Quantitative Single-Molecule Detection at Ultra low Concentrations Analytical Chemistry, 82, 14, 6299-6302. pdf - Supplemental information
    New fibre optical diagnostic method to screen for rare targets in a liquid environment


    Braun, T., Ghatkesar, M.K., Backmann, N. Grange, W., Boulanger, P., Letellier, L., Lang, H.P., Bietsch, A., Gerber, C., Hegner, M. (2009) Quantitative time-resolved measurement of membrane protein-ligand interactions using microcantilever array sensors Nature Nanotech. 4, 179-185. (doi:10.1038/NNANO.2008.398 ) pdf ; supplemental Information Development of a new quantitative virus biosensor. Nanomechanical silicon sensors functionalized with biomembranes detects specifically the presence of virus in liquid environments within minutes.


    Ghatkesar, M. K., Lang, H. P., Gerber, C., Hegner, M., Braun, T. (2008) Comprehenisive characterization of molecular interactions based on nanomechanics PLoS ONE, 2008;3(11):e3610. pdf Online tracking of pore formation in lipid vesicles - Combined mode - qualitative and quantitative readout

    Ghatkesar, M. K., Rakhmatullina, E., Lang, H. P., Gerber, Ch., Hegner, M., Braun, T. (2008) Multi-parameter microcantilever sensor for comprehensive characterization of Newtonian fluids Sens. Actuators B:Chemical, 135,133-138. pdf Micro-rheological measurements using oscillating nanomechanical sensors

    Huber, F., Lang, H. P., Hegner, M., Despont, M., Drechsler, U., Gerber, Ch. (2008) Analyzing refractive index changes and differential bending in microcantilever arrays Rev. Sci. Instr. 79, 086110. pdf Assessment of liquid contributions to optically readout nanomechanical signals

    Grange, W., Haas, P., Wild, A., Lieb, M.A., Calame, M., Hegner, M., Hecht, B. (2008) Detection of transient events in the presence of background noise J. Phys. Chem. B 112 (23) 7140-7144. pdf Single molecule detection using optical fibres in a turbulent flow

    Grange, W., Duckely, M., Husale, S., Jacob,S., Engel, A. and Hegner, M. (2008) VirE2: A Unique ssDNA Compacting Molecular Machine PLoS Biol 6(2) 343-351: pdf additional Supplemental Information Bacterial infection in plants. Genetic molecules which transfer into cellular compartment are spooled through the membrane by powerful molecular motor. Optical tweezers assay reveals forces involved in the process

    Husale, S., Grange,W., Karle, M.,Bürgi, S., Hegner, M. (2008) Interaction of cationic surfactants with DNA: a single-molecule study Nucleic Acids Res., 36 (5), 1443-1449. pdf Optical tweezers experiment describing nanomechanical effect of charged molecules on single DNA molecules. Comparable molecules are applied in gene therapy for the translocation of DNA into cells

    Ghatkesar, M.K., Braun, T., Barwich, V., Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P. (2008) Resonating modes of vibrating microcantilevers in liquid Appl. Phys. Lett. 92(4), 043106. pdf Higher mode oscillation of micro cantilevers in liquids environment provide pg/Hz resolution


    Ghatkesar, MK; Barwich, V; Braun, T, Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P., Drechsler, U., Despont, M. (2007) Higher modes of vibration increase mass sensitivity in nanomechanical microcantilevers Nanotechnology 18, 445502. pdf

    Braun, T., Huber, F., Ghatkesar, M.K., Backmann, N., Lang, H.P., Gerber, C., Hegner, M. (2007) Processing of kinetic microarray signals Sens. Act. B -Chemical, 128, 75-82. pdf

    Braun,T., Ghatkesar,M K., Barwich,V., Backmann, N., Huber, F., Grange, W.,Nugaeva, N., Lang, H. P., Ramseyer,J P., Gerber, Ch. and Hegner, M . (2007) Digital processing of multi-mode nano-mechanical cantilever data J. Phys.: Conf. Ser. 61, 341, doi:10.1088/1742-6596/61/1/069. pdf

    Park, K.K., Lee, H,J.,Yaralioglu, G.G., Ergun, A.S., Oralkan, O., Kupnik, M., Quate, C.F., Khuri-Yakub, B.T., Braun, T., Ramseyer, J.P., Lang, H.P., Hegner, M., Gerber, Ch., Gimzewski, J.K. (2007) Capacitive micromachined ultrasonic transducers for chemical detection in nitrogen Appl. Phys. Lett. 91, 094102. pdf

    Gerber, Ch. Hegner, M., Meyer, E. Special issue featuring papers from ICN&T 2006 Nanotechnology, ,18, 040201. pdf

    Huber, F., Backmann, N., Grange, W., Hegner, M., Gerber, Ch. and Lang, H.P. (2007) Analyzing Gene Expression Using Combined Nanomechanical Cantilever Sensors J. Phys.: Conf. Ser. 61 450 doi:10.1088/1742-6596/61/1/090. pdf

    Lang, H.P., Ramseyer, J.P., Grange, W., Braun, T., Schmid, D., Hunziker, P., Jung, C., Hegner, M.. and Gerber, Ch. (2007) An artificial nose based on microcantilever array sensors J. Phys.: Conf. Ser. 61 663 doi:10.1088/1742-6596/61/1/133, pdf

    Dorrestijn, M., Bietsch, A., Açikalin, T., Raman, A., Hegner, M., Meyer, E.* and Ch. Gerber (2007) Chladni Figures Revisited based on Nanomechanics Phys. Rev. Lett. 98, 026102. pdf

    Watari, M., Galbraith, J. Lang, H.P., Sousa, M., Hegner, M., Gerber, Ch., Horton, M.A. and McKendry, R.A.* (2007) Investigating the Molecular Mechanisms of In-plane Mechanochemistry on Cantilever Arrays J. Am. Chem. Soc. 129, 601-609. pdf ; pdf_supportfile

    Nugaeva, N., Gfeller, K., Backmann, N., Lang, H.P., Guntherodt, H.J., Hegner, M.(2007) An antibody-sensitized microfabricated cantilever for the growth detection of Aspergillus niger spores Microscopy and Microanalysis, 13,13-17. pdf


    Zhang, J., Lang, H. P., Bietsch, A., Huber, F., Certa, U., Guntherodt, H.-J., Hegner, M.* Gerber, Ch. (2006) Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA Nature Nanotechnology, 1 ,214-220. pdf

    Braun, T., Backmann, N., Bietsch, A., Engel, A., Lang, H.P., Gerber, Ch., Hegner, M.* (2006) Conformational change of bacteriorhodopsin quantitatively monitored by microcantilever sensors Biophys. J., 90, 2970-2977. pdf

    H.P. Lang*, Hegner M. and Gerber Ch. (2006) Microfabricated Cantilever Array Sensors for (Bio-) Chemical Detection in: Applied Scanning Probe Methods IV - Industrial Applications, B. Bhushan, H. Fuchs (Eds.), Springer Verlag (Berlin, New York, Heidelberg), Ch. 28, pp. 183-213. pdf

    H.P. Lang*, Hegner M. and Gerber Ch. (2006) Nanomechanical Cantilever Array Sensors, in: Springer Handbook of Nanotechnology, 2nd edition, Springer Verlag (Berlin, New York, Heidelberg), Ch. 16, pp. 443-450. pdf


    Huber, F., Hegner, M., Gerber, Ch.,Guntherodt, H.J., Lang, H.P.* (2005) Label free analysis of transcription factors using microcantilever arrays Biosens. Bioelectron. 21 (8) 1599 - 1605. pdf

    Lang, H.P.*, Hegner, M., Gerber, Ch. (2005) Cantilever array sensors Materials today 8, 30-36. pdf

    Gfeller, K.Y, Nugaeva, N., Hegner, M.* (2005) Rapid biosensor for the detection of selective growth of Escherichia coli Appl. Env. Microbiol. 71 (5): 2626-2631. pdf

    Bertoncini, P.*, Schoenauer, R., Agarkova, I., Hegner, M., Perriard, J.-C., Guntherodt, H.-J. (2005) Study of the Mechanical Properties of Myomesin Proteins Using Dynamic Force SpectroscopyJ. Mol. Biol. 348 (5): 1127-1137. pdf

    Schoenauer, R., Bertoncini, P., Machaidze, G., Aebi, U., Perriard, J.C.*, Hegner, M.*, Agarkova, I. (2005) Myomesin is a molecular spring with adaptable elasticity J. Mol. Biol. 49 (2): 367-379. pdf

    Gfeller, K., Nugaeva, N., Hegner, M.* (2005) Micromechanical oscillators as rapid biosensors for the detection of active growth of Escherichia coli Biosens. Bioelectron. 21(3) 528-533. pdf

    Shahgaldian P.*, Pieles U, Hegner M. (2005) Enantioselective recognition of phenylalanine by a chiral amphiphilic macrocycle at the air-water interface: A copper-mediated mechanism Langmuir 21 (14): 6503-6507. pdf

    Shahgaldian, P.*, Hegner, M., Pieles, U. (2005) A cyclodextrin Self-Assembled Monolayer (SAM) based surface plasmon resonance (SPR) sensor for enantioselective analysis of thyroxine J. Incl. Phenom. 53, 35-39. pdf

    Braun, T., Barwich, V., Ghatkesar, M.K., Bredekamp, A.H., Gerber, Ch., Hegner, M.*, Lang, H.P.* (2005) Mass sensors for biomolecular detection in physiological environment Phys. Rev. E, 72, 031907, 1-9. pdf

    Backmann, N., , Zahnd, Ch., Huber, F., Bietsch, A., Pluckthun, A., Lang, H.P., Guntherodt, H.J., Hegner, M.*, Gerber, Ch. (2005) A label-free immunosensor array using single-chain antibody fragments Proc. Natl. Acad. Sci. USA, 102 (41),14587-14592. pdf

    Nugaeva, N., Gfeller, K.Y., Backmann, N., Lang, H.P., Düggelin, M., Hegner, M. (2005) Nanomechanical cantilever array sensors for selective fungal immobilization and real-time growth detection Biosens. Bioelectron. 21, 849-856. pdf


    Engel, A. & Hegner, M.* (2004). Atomic Force Microscopy & Laser Tweezers. Physics meets Biology, in: Matter and Materials (Gompper, G., Kaupp, U.B., Dhont, J.K.G., Richter, D. Winkler, R.G., Ed.), 19, Forschungszentrum Jülich, Jülich

    Schwarzenbach, M.S.*, Reimann, P., Thommen, V., Hegner, M., Mumenthaler, M., Schwob, J., Guntherodt, H.J. (2004) Topological structure and chemical composition of inner surfaces of borosilicate vials PDA J. Pharm. Sci. Technol. 58 (3)169-175. pdf

    Bietsch, A.*, Hegner, M., Lang, H.P., Gerber, C. (2004) Inkjet deposition of alkanethiolate monolayers and DNA oligonucleotides on gold: Evaluation of spot uniformity by wet etching Langmuir 20 (12): 5119-5122. pdf

    Bietsch, A.*, Zhang, J.Y., Hegner, M., Lang, H.P., Gerber, Ch.(2004) Rapid functionalization of cantilever array sensors by inkjet printing Nanotechnology 15 (8): 873-880. pdf

    Hegner, M.* (2004) The Basel NanoBio-Network Chimia 58, 788 - 791. pdf

    Ghatkesar M. K., Barwich, V., Braun, T., Bredekamp, A.H., Drechsler, U., Despont, M., Lang, H. P., Hegner, M.*, Gerber Ch. (2004) RealTime Mass Sensing by Nanomechanical Resonators in Fluid Proc. IEEE Sensors 2004 1060 – 1063. pdf


    Hegner, M. * and Grange, W. (2003) Mechanics and imaging of single DNA molecules. J. Muscl. Res. Cell Mot. 23,367-375. pdf

    Arntz, Y., Seelig, J.E., Zhang, J., Lang, H.P., Hunziker, P., Ramseyer, J.P., Meyer, E., Hegner, M.*, and Gerber, Ch. (2003) A label-free protein assay based on a nanomechanical cantilever array Nanotechnology 14, 86-90. pdf

    Hegner, M.* and Arntz, Y. (2003) Advanced Biosensing Using Micromechanical Cantilever Arrays Methods in Molecular Biology 24, 39-49. pdf

    Hegner, M.*, Grange, W. and Bertoncini, P. (2003) Measurement of Single Molecular Interactions by Dynamic Force Microscopy Methods in Molecular Biology 24, 369-382. pdf

    Hegner, M.*, Gerber, Ch., Arntz, Y., Zhang, J., Bertoncini, P., Husale, S., Lang, H.P. and Grange, W. (2003) Biological Single Molecule Applications and Advanced Biosensing J. Chrom. Lib. 68, 241 - 263. in Emerging Technologies in Protein and Genomic Material Analysis (G.A. Marko-Varga, P.L. Orozlan Eds.) pdf


    Schumakovitch, I., Grange, W., Strunz, T., Bertoncini, P., Guntherodt, H.-J. and Hegner M.* (2002) Temperature Dependence of Unbinding Forces between Complementary DNA Strands Biophys J. 82, 517-521. pdf

    Schwarzenbach, M.S., Reimann, P., Thommen, V., Hegner, M., Mumenthaler, M., Schwob, J., Guntherodt, H.J. * (2002) Interferon alpha-2a interactions on glass vial surfaces measured by atomic force microscopy PDA J. Pharm. Sci. Technol. 56, 78-89. pdf

    Grange, W., Husale, S., Guntherodt, H.-J. and Hegner, M. * (2002) Optical tweezers system measuring the change in light momentum flux Rev. Sci. Instr. 73, 2308 2316. pdf

    Husale, S., Grange, W. and Hegner, M. * (2002) DNA Mechanics Affected by Small DNA Interacting Ligands Single Mol. 3 ,(2-3), 91-96. pdf

    McKendry, R., Zhang, J., Arntz, Y., Strunz, T., Hegner, M., Lang, H.P. *, Baller, M.K., Certa, C., Meyer, E., Güntherodt, H.-J. and Gerber, C. (2002) Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array Proc. Natl. Acad. Sci. USA 99 (15), 9783–9788. pdf

    Hegner M.* (2002) Optics - The light fantastic Nature 419 (6903): 126-127. pdf

    Lang, H.P. *, Hegner, M., Meyer, E and Gerber, C. (2002) Nanomechanics from atomic resolution to molecular recognition based on atomic force microscopy technology Nanotechnology 13, R29-R36. pdf

    Hegner, M. * and Engel, A. (2002) Single Molecule Imaging and Manipulation Chimia 56, 506 - 514. pdf

    Lang, H.P. *, Hegner, M., Gerber, C. (2002) Nanomechanics - The Link to Biology and Chemistry Chimia 56, 515 - 519. pdf


    Hegner M. * and Guntherodt, H.-J. (2001) Nanometer Scale Science and Technology - The impact of STM and AFM International School of Physics Enrico Fermi Volume 144, 1-40. pdf

    Grange W., Strunz T., Schumakovitch I., Guntherodt, H.-J. and Hegner, M. * (2001) Molecular Recognition and Adhesion of Individual DNA Strands Studied by Dynamic Force Microscopy Single Mol. 2 (2), 75-78. pdf


    Hegner, M. * (2000) DNA Handles for Single Molecule Experiments Single Mol. 1 (2) 139-144. pdf

    Strunz, T., Oroszlan, K., Schumakovitch, I., Guntherodt, H.-J. and Hegner M.* (2000) Model energy landscapes and the force-induced dissociation of ligand-receptor bonds Biophys. J. 79, 1206-1212. pdf

    De Paris, R., Strunz, T., Oroszlan, K., Guntherodt, H.-J. and Hegner, M. * (2000) Force Spectroscopy and Dynamics of the Biotin-Avidin Bond Studied by Scanning Force Microscopy Single Mol. 1 (4) 285-290. pdf


    Hegner, M., Smith, S.B. and Bustamante, C. * (1999) Polymerization and mechanical properties of single RecA-DNA filaments Proc. Natl. Acad. Sci. USA 96 (18), 10109-10114. pdf


    Hegner, M.* and Wagner, P. (1998) Ultraflat Au surfaces (TSG) for biological SPM applications, in: Procedures in Scanning Probe Microscopy, ed. Colton et al., Wiley & Sons Ltd. New York, 172-175. pdf

    Wagner, P. * and Hegner, M. (1998) A general method for immobilizing biomolecules on gold for SPM in aqueous buffers, in: Procedures in Scanning Probe Microscopy, ed. Colton et al., Wiley & Sons Ltd. New York, 481-487. pdf


    Hegner, M. *, Dreier, M., Wagner, P., Semenza, G. and Guntherodt, H.-J. (1996) Modified DNA immobilized on bioreactive self-assembled monolayer on gold for dynamic force microscopy imaging in aqueous buffer solution J. Vac. Sci. Technol. B, 14, 1418-1421. pdf

    Dammer, U., Hegner, M. *, Anselmetti, D., Wagner, P., Dreier, M., Huber, W. and Guntherodt, H.J. (1996) Specific Antigen/Antibody interactions measured by Force Microscopy Biophys. J., 70, 2437-2441. pdf

    Wagner, P. *, Kernen, P., Zaugg, F., Hegner, M. and Semenza, G. (1996) omega-Functionalized self-assembled monolayers chemisorbed on ultraflat Au(111) surfaces for biological scanning probe microscopy in aqueous buffers J. Vac. Sci. Technol. B, 14, 1466-1471. pdf

    Wagner, P., Hegner, M., Kernen, P., Zaugg, F. and Semenza, G.* (1996) N-hydroxysuccinimide ester functionalized self-assembled monolayers for covalent immobilization of biomolecules on gold Biophys. J., 70, 2052-2066. pdf

    Weigert, S. *, Dreier, M. and Hegner, M. (1996) Frequency shifts of cantilevers vibrating in various media Appl. Phys. Lett. 69, 2834-2836. pdf


    Dammer, U., Anselmetti, D., Dreier, M., Hegner, M., Huber, W., Hurst, J., Misevic, G.N. and Guntherodt, H.J. * (1995) Measuring molecular adhesion with force microscopy Forces in SPM, NATO-ASI Serie E, Vol. 286, 625-632. pdf

    Wagner, P., Hegner, M., Guntherodt, H.-J. and Semenza, G.* (1995) Formation and in-situ modification of monolayers chemisorbed on template-stripped gold surfaces for operations on nano-scale Langmuir,11, 3867-3875. pdf

    Dammer, U., Popescu, O., Wagner, P., Anselmetti, D., Guntherodt, H.J., Misevic, G.N. (1995 ) Binding strength between cell adhesion proteoglycans measured by atomic force microscopy Science 267(5201):1173-5. pdf


    Shelden, R.A. *, Meier, L.P., Caseri, W.R., Suter, U.W., Hermann, R., Muller, M., Hegner, M. and Wagner, P. (1994) Nanophase molecular droplets: individual polystyrene molecules on mica imaged with scanning electron and atomic-force microscopy Polymer, 35, 1571-1575. pdf

    Wagner, P., Kernen, P., Hegner, M., Ungewickell, E. and Semenza, G. * (1994) Covalent anchoring of proteins onto gold-directed NHS-terminated self-assembled monolayers in aqueous buffers: SFM imaging of Clathrin and its cages FEBS Letters, 356, 267-271. pdf

    Dammer,U. und Hegner, M. (1994) Neue "Augen" für Biologen, UniNova 72/94, 38-40. pdf


    Hegner, M., Wagner, P. and Semenza, G. * (1993) Ultralarge atomically flat template-stripped Au surfaces for scanning probe microscopy Surface Science, 291, 39-46. pdf

    Hegner, M., Wagner, P. and Semenza, G. * (1993) Immobilizing DNA on gold via thiol modification for atomic force microscopy imaging in buffer solutions FEBS Letters, 336, 452-456. pdf


    Hegner, M., Kieckebusch-Gück A. v., Falchetto, R., James, P., Semenza, G. and Mantei, N.* (1992) Single amino acid substitutions can convert the uncleaved signal-anchor of sucrase-isomaltase to a cleaved signal sequence, J. Biol. Chem., 267, 16928-16933. pdf