Papers from the Nanomechanics Team

Google Scholar: Martin Hegner
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SARS-CoV-2 variants

Brunetti, G., De Pastina, A. and Hegner, M. (2021) Quantitative epitope analysis reveals drastic 63% reduced immuno-affinity and 60% enhanced transmissibility for SARS-CoV-2 variants. Nanoscale Advances 3, 6903–6911; DOI: 10.1039/d1na00554e
Direct label-free analysis of SARS-CoV2 variants side by side.
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Brunetti, G., De Pastina, A. and Hegner, M. (2021) Rapid Label-free Nanotechnological Immunoassay for Analysis of Candidate Malaria Vaccines. Appl. Cell Biol. 9 (2) 29-32 DOI: 10.53043/2320-1991.acb90006
Commentary to Brunetti et al Nanoscale 2021 (Nanotechnological immunoassay ...).
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Frequency Tracking

De Pastina, A., Padovani, F., Brunetti, G., Rotella, C., Niosi, F., Usov. V. and Hegner, M. (2021) Multimodal real-time frequency tracking of cantilever arrays in liquid environment for biodetection: Comprehensive setup and performance analysis. Review of Scientific Instruments 92, 065001, DOI: 10.1063/5.0047631
Multi PLL tracking of higher mode cantilever arrays with 18 sensors in fluids.
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Front cover of Namoscale

Brunetti, G., Padovani, F., De Pastina, A., Rotella,C., Monahan, A., Hoffman, S., Jongo, S., Abdulla, S., Corradin, G., Pluschke, G., Daubenberger, C. and Hegner, M. (2021) Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines. Nanoscale 13, 2338 - 2349 DOI: 10.1039/D0NR08083G
Quick, quantitative label-free diagnostics of malaria vaccine candidates.
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104.     Brunetti, G., De Pastina, A. and Hegner, M. (2021) Quantitative epitope analysis reveals drastic 63% reduced immuno-affinity and 60% enhanced transmissibility for SARS-CoV-2 variants Nanoscale Advances 3, 6903–6911; DOI: 10.1039/d1na00554e PDF
Direct label-free analysis of SARS-CoV2 variants side by side.

103.     Brunetti, G., De Pastina, A. and Hegner, M. (2021) Rapid Label-free Nanotechnological Immunoassay for Analysis of Candidate Malaria Vaccines Appl. Cell Biol. 9 (2) 29-32 DOI: 10.53043/2320-1991.acb90006 PDF
Commentary to Brunetti et al Nanoscale 2021 (Nanotechnological immunoassay ...).

102.     De Pastina, A., Padovani, F., Brunetti, G., Rotella, C., Niosi, F., Usov. V. and Hegner, M. (2021) Multimodal real-time frequency tracking of cantilever arrays in liquid environment for biodetection: Comprehensive setup and performance analysis Review of Scientific Instruments 92, 065001, DOI: 10.1063/5.0047631 PDF
Multi PLL tracking of higher mode cantilever arrays with 18 sensors in fluids.

101.     Brunetti, G., Padovani, F., De Pastina, A., Rotella,C., Monahan, A., Hoffman, S., Jongo, S., Abdulla, S., Corradin, G., Pluschke, G., Daubenberger, C. and Hegner, M. (2021) Nanotechnological immunoassay for rapid label-free analysis of candidate malaria vaccines Nanoscale 13, 2338 - 2349 DOI: 10.1039/D0NR08083G PDF
Quick, quantitative label-free diagnostics of malaria vaccine candidates.


100.     Padovani, F. and Hegner, M. (2019) Novel strategies for clinical coagulation diagnostics and therapy monitoring Clin. Lab. Int 43, 20-22 PDF


99.     Duffy, J., Padovani, F., Brunetti, G., Noy, P., Certa, U., Hegner, M. (2018) Towards personalised rapid label free miRNA detection for cancer and liver injury diagnostics in cell lysates and blood based samples Nanoscale 10, 12797-12804; doi: 10.1039/c8nr03604g PDF
Novel strategy for quick, reliable and quantitative diagnostics of expression patterns of non-coding short RNA in blood plasma or cell cultures

98.     Li-Qing Zheng, L., Wang, X., Shao, F., Hegner, M., Zenobi, R. (2018) Nanoscale Chemical Imaging of Reversible Photoisomerization of an Azobenzene-Thiol Self-Assembled Monolayer by Tip-Enhanced Raman Spectroscopy Angew. Chem. Intl. Ed. 57, 1025-1029; doi:10.1002/anie.201710443 PDF
Switching’ on the edge: The reversible photoisomerization of an azobenzene thiol (ABT) self-assembled monolayer was demonstrated by tip-enhanced Raman spectroscopy with nanoscale spatial resolution


97.     Lang, H.P., Hegner, M., Gerber, C. (2017). Nanomechanical Cantilever Array Sensors. In: Bhushan, B. (eds) Springer Handbook of Nanotechnology. Springer Handbooks. Springer, Berlin, Heidelberg. PDF

96.     Padovani, F., Duffy, J., Hegner, M. (2017) Nanomechanical clinical coagulation diagnostics and monitoring of therapies Nanoscale 9, 17939 - 17947; doi:10.1039/C7NR06992H PDF
Nano-oscillations of microcantilevers as a novel strategy to diagnose and monitor blood coagulation disorders, using a few microliters of the sample

95.     Wruck, F., Katranidis, A., Nierhaus, K.H., Büldt, G., Hegner, M. (2017) Translation and folding of single proteins in real-time Proc. Natl. Acad. Sci. USA 114 (22) E4399-E4407; doi:10.1073/pnas.1617873114 PDF
Study that elucidates the intricate relationship between a protein’s amino acid sequence, its cotranslational nascent chain elongation rate and folding

94.  Padovani, F., Duffy, J., Hegner, M. (2017) Microrheological Coagulation Assay Exploiting Micromechanical Resonators Analytical Chemistry 89 (1), 751 - 758; doi:10.1021/acs.analchem.6b03347 PDF
Microrheologial Clinical Assay for Blood Anomalies


93.  Jadhav, V.S., Brüggemann, D., Wruck, F., Hegner, M. (2016) Single-molecule mechanics of protein-labelled DNA handles Beilstein J. Nanotechnol. 7, 138–148. DOI:10.3762/bjnano.7.16 PDF
Modified DNA handles for single molecule experiments


92.  Sinead Winters, Nina C. Berner, Rohit Mishra, Kim C. Dumbgen,Claudia Backes, Martin Hegner, Andreas Hirsch and Georg S. Duesberg (2015) On-surface derivatisation of aromatic molecules on graphene: the importance of packing density ChemComm 51, 16778, DOI: 10.1039/c5cc06433c PDF
Chemical functionalisation of graphene interfaces

91.  Walther, M.,Fleming, P.M., Padovani, F., Hegner, M. (2015) An optimized measurement chamber for cantilever array measurements in liquid incorporating an automated sample handling system EPJ Techniques and Instrumentation 2:7, DOI 10.1140/epjti/s40485-015-0017-7 PDF Movie of liquid exchange in cantilever array measurement chamber
A detailed description of our latest analytical cantilever array sensing device. Fluidics, differential read-out and sample analysis


90.  Maloney, N., Lukacs, G., Jensen, J. Hegner, M. (2014) Nanomechanical Sensors for Single microbial cell growth monitoring Nanoscale 6, 8242-8249, DOI: 10.1039/C4NR01610F PDF
Mechanical testing of single cells in real-time

89.  Mishra, R., Hegner, M. (2014) Effect of non-specific species competition from total RNA on the static mode hybridization response of nanomechanical assays of oligonucleotides Nanotechnology 25, 225501 doi: 10.1088/0957-4484/25/22/225501 PDF
Detecting short nucleic acids in a coplex total RNA background

88.  Maloney, N., Lukacs, G., Ball,S. L., Hegner, M. (2014) Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers Rev. Sci. Instrum. 85, 015003;  PDF
Growth monitoring of microfungi on nanomechanical sensors


87.  Jensen, J., Maloney, N., Hegner, M. (2013) A multi-mode platform for cantilever arrays operated in liquid Sensors and Actuators B: Chemical 183, 388–394 doi: 10.1016/j.snb.2013.03.133 PDFInstrumental details on nanomechanical quantitative cantilever optical beam device


86.  Hegner, M., Bruggemann, D., Skoko, D. (2012) Optical Tweezers, Encyclopedia of Nanotechnology, Bhushan, Bharat (Ed.), Springer, ISBN 978-90-481-9750-7, pages 1981 - 1991 PDF
Overview article on Optical Tweezes Technology

85.  Lukacs, G. Maloney, N. and Hegner, M. (2012) Ink-Jet Printing: Perfect Tool for Cantilever Array Sensor Preparation for Microbial Growth Detection Journal of Sensors Vol 2012, Article ID 561256, 7 pages doi:10.1155/2012/561256 PDF
Automation of cantilever functionalization with cells

84.  Daly, R., Kumar, S., Lukacs, G., Lee, K., Weidlich, A., Hegner, M., Duesberg, G.S. (2012) Cell Proliferation Tracking Using Graphene Sensor Arrays Journal of Sensors, Article ID 219485, 7 pages doi:10.1155/2012/219485 PDF
Graphene arrays for bioanalytical analysis

83.  Noy, P., Steiner, R., Voelkle, J., Hegner, M. and Fattinger, Ch. (2012) Instrument for Label-Free Detection of Noncoding RNAs Journal of Sensors, Article ID 208079, 5 pages. doi:10.1155/2012/208079 PDF 
Continous flow nanomechanical measurements in Industry

82.  Jensen, J., Farina, M., Zuccheri, G., Grange, W. and Hegner, M. (2012) Quantitative, Label-Free Detection of the Aggregation of α-Synuclein Using Microcantilever Arrays Operated in a Liquid Environment Journal of Sensors Vol. 2012 (2012), Article ID 874086, 7 pages doi:10.1155/2012/874086 PDF
Protein aggregation as a cause for neurodegenerative diseases

81.  Mishra, R., Grange, W. and Hegner, M. (2012) Rapid and Reliable Calibration of Laser Beam Deflection System for Microcantilever-Based Sensor Setups Journal of Sensors Vol. 2012 Article ID 617386, 6 pages, doi:10.1155/2012/617386 PDF
Geometrical differences require precise calibration of individual devices

80.  Maloney, N., Lukacs, G., Nugaeva, N., Grange, W., Ramseyer, J. P., Jensen, J., Hegner, M. (2012) Fibre Optic Readout of Microcantilever Arrays for Fast Microorganism Growth Detection," Journal of Sensors, vol. 2012, Article ID 405281, 6 pages. doi:10.1155/2012/405281 PDF 
Rapid microfungus growth analyis using nanomechanical sensors

79.  Jensen, J. and Hegner, M. (2012) Predictions of the Compressible Fluid Model and its Comparison to Experimental Measurements of Q Factors and Flexural Resonance Frequencies for Microcantilevers Journal of Sensors, vol. 2012, Article ID 258381, 7 pages. doi:10.1155/2012/258381 PDF 
Inverse behaviour of Quality factors observed in higher modes in the gas phase


78.  Park, K. K., Lee, H., Kupnik, M., Oralkan, O., Ramseyer, J. P., Lang, H. P., Hegner, M., Gerber, C., Khuri-Yakub, B. T. (2011) Capacitive micromachined ultrasonic transducer (CMUT) as a chemical sensor for DMMP detection Sensors and Actuators B-Chemical 160, 1120-1127. doi: 10.1016/j.snb.2011.09.036
Chemical sensing at the limit of 56 ppb of DMMP (Sarin alanog) by CMUT chemical sensors

77.  Katranidis, A., Grange, W., Schlesinger, R.,Choli-Papadopoulou, T., Bruggemann, D., Hegner, M., Buldt, G. (2011) Force measurements of the disruption of the nascent polypeptide chain from the ribosome by optical tweezers FEBS Letters, 585, 1859–1863.doi: 10.1016/j.febslet.2011.04.045 PDF
Supplemental Video - Real-time synthesis of Ribosomes
Using optical forces the molecular strength of the nascent polypeptide chain anchored in the ribosome machinery are determined


76.  Springer Handbook of Nanotechnology. Chapter: 'Nanomechanical Cantilever Array Sensors' Hans Peter Lang, Martin Hegner, Christoph Gerber Pages 427-452; ISBN: 978-3-642-02524-2 (Print) PDF

75.  Haas, P.,Then, P., Wild, A., Grange, W., Zorman, S., Hegner, M., Calame, M., Aebi, U., Flammer, J., Hecht, B. (2010) Fast Quantitative Single-Molecule Detection at Ultra low Concentrations Analytical Chemistry, 82, 14, 6299-6302 PDF
New fibre optical diagnostic method to screen for rare targets in a liquid environment 


74.  Braun, T., Ghatkesar, M.K., Backmann, N. Grange, W., Boulanger, P., Letellier, L., Lang, H.P., Bietsch, A., Gerber, C., Hegner, M. (2009) Quantitative time-resolved measurement of membrane protein-ligand interactions using microcantilever array sensors Nature Nanotech. 4, 179-185. (doi:10.1038/NNANO.2008.398 ) PDF
Development of a new quantitative virus biosensor. Nanomechanical silicon sensors functionalized with biomembranes detects specifically the presence of virus in liquid environments within minutes.


73.  Ghatkesar, M. K., Lang, H. P., Gerber, C., Hegner, M., Braun, T. (2008) Comprehenisive characterization of molecular interactions based on nanomechanics PLoS ONE, 2008;3(11):e3610 PDF 
 Online tracking of pore formation in lipid vesicles - Combined mode - qualitative and quantitative readout 

72.  Ghatkesar, M. K., Rakhmatullina, E., Lang, H. P., Gerber, Ch., Hegner, M., Braun, T. (2008) Multi-parameter microcantilever sensor for comprehensive characterization of Newtonian fluids Sens. Actuators B:Chemical, 135,133-138 PDFMicro-rheological measurements using oscillating nanomechanical sensors

71.  Huber, F., Lang, H. P., Hegner, M., Despont, M., Drechsler, U., Gerber, Ch. (2008) Analyzing refractive index changes and differential bending in microcantilever arrays Rev. Sci. Instr. 79, 086110 PDF
Assessment of liquid contributions to optically readout nanomechanical signals 

70.  Grange, W., Haas, P., Wild, A., Lieb, M.A., Calame, M., Hegner, M., Hecht, B. (2008) Detection of transient events in the presence of background noise J. Phys. Chem. B 112 (23) 7140-7144 PDF
Single molecule detection using optical fibres in a turbulent flow 

69.  Grange, W., Duckely, M., Husale, S., Jacob,S., Engel, A. and Hegner, M. (2008) VirE2: A Unique ssDNA Compacting Molecular Machine PLoS Biol 6(2) 343-351 PDF
Bacterial infection in plants. Genetic molecules which transfer into cellular compartment are spooled through the membrane by powerful molecular motor. Optical tweezers assay reveals forces involved in the process 

68.  Husale, S., Grange,W., Karle, M.,Bürgi, S., Hegner, M. (2008) Interaction of cationic surfactants with DNA: a single-molecule study Nucleic Acids Res., 36 (5), 1443-1449 PDF
Optical tweezers experiment describing nanomechanical effect of charged molecules on single DNA molecules. Comparable molecules are applied in gene therapy for the translocation of DNA into cells 

67.  Ghatkesar, M.K., Braun, T., Barwich, V., Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P. (2008) Resonating modes of vibrating microcantilevers in liquid Appl. Phys. Lett. 92(4), 043106 PDF
Higher mode oscillation of micro cantilevers in liquids environment provide pg/Hz resolution 


66.  Ghatkesar, MK; Barwich, V; Braun, T, Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P., Drechsler, U., Despont, M. (2007) Higher modes of vibration increase mass sensitivity in nanomechanical microcantilevers Nanotechnology 18, 445502 PDF
Cantilever damping in liquid - moving to higher oscillation modes enhances Q factor

65.  Braun, T., Huber, F., Ghatkesar, M.K., Backmann, N., Lang, H.P., Gerber, C., Hegner, M. (2007) Processing of kinetic microarray signals Sens. Act. B -Chemical, 128, 75-82 PDFLong duration measurements of cantilevers in liquid require specific data analysis

64.  Braun,T., Ghatkesar,M K., Barwich,V., Backmann, N., Huber, F., Grange, W.,Nugaeva, N., Lang, H. P., Ramseyer,J P., Gerber, Ch. and Hegner, M . (2007) Digital processing of multi-mode nano-mechanical cantilever data J. Phys.: Conf. Ser. 61, 341, doi:10.1088/1742-6596/61/1/069 PDF 
Dynamic mode and static mode data analysis

63.  Park, K.K., Lee, H,J.,Yaralioglu, G.G., Ergun, A.S., Oralkan, O., Kupnik, M., Quate, C.F., Khuri-Yakub, B.T., Braun, T., Ramseyer, J.P., Lang, H.P., Hegner, M., Gerber, Ch., Gimzewski, J.K. (2007) Capacitive micromachined ultrasonic transducers for chemical detection in nitrogen Appl. Phys. Lett. 91, 094102 PDFcMUT functionalization with ink-jet spotting

62.  Gerber, Ch. Hegner, M., Meyer, E. Special issue featuring papers from ICN&T 2006 Nanotechnology, ,18, 040201 PDF
ICN&T with >1500 participants was orgenised in Basel, Switzerland to celebate the development of STM and AFM and Nanotechnology in general 

61.  Huber, F., Backmann, N., Grange, W., Hegner, M., Gerber, Ch. and Lang, H.P. (2007) Analyzing Gene Expression Using Combined Nanomechanical Cantilever Sensors J. Phys.: Conf. Ser. 61 450 doi:10.1088/1742-6596/61/1/090 PDF 
Combined RNA and protein measurements in liquid

60.  Lang, H.P., Ramseyer, J.P., Grange, W., Braun, T., Schmid, D., Hunziker, P., Jung, C., Hegner, M.. and Gerber, Ch. (2007) An artificial nose based on microcantilever array sensors J. Phys.: Conf. Ser. 61 663 doi:10.1088/1742-6596/61/1/133 PDF 
Gas sensing of odours using polymer coated cantilever sensors

59.  Dorrestijn, M., Bietsch, A., Açikalin, T., Raman, A., Hegner, M., Meyer, E.* and Ch. Gerber (2007) Chladni Figures Revisited based on Nanomechanics Phys. Rev. Lett. 98, 026102 PDFAccumulation of nano- and micro-particles at anti-nodes and nodes of oscillating cantilevers in liquid

58.  Watari, M., Galbraith, J. Lang, H.P., Sousa, M., Hegner, M., Gerber, Ch., Horton, M.A. and McKendry, R.A.* (2007) Investigating the Molecular Mechanisms of In-plane Mechanochemistry on Cantilever Arrays J. Am. Chem. Soc. 129, 601-609 PDFSelf-Assembled-Monolayer mechanics upon pH changes

57.  Nugaeva, N., Gfeller, K., Backmann, N., Lang, H.P., Guntherodt, H.J., Hegner, M.(2007) An antibody-sensitized microfabricated cantilever for the growth detection of Aspergillus niger spores Microscopy and Microanalysis, 13,13-17 PDF 
Capturing micro-fungi on sensor for growth analysis


56.  Zhang, J., Lang, H. P., Bietsch, A., Huber, F., Certa, U., Guntherodt, H.-J., Hegner, M.* Gerber, Ch. (2006) Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA Nature Nanotechnology, 1 ,214-220 PDFmRNA gene activation detection in complex backgrounds 

55.  Braun, T., Backmann, N., Bietsch, A., Engel, A., Lang, H.P., Gerber, Ch., Hegner, M.* (2006) Conformational change of bacteriorhodopsin quantitatively monitored by microcantilever sensors Biophys. J., 90, 2970-2977 PDF 
Conformational change of membrane protein detected mechanically with cantilever sensors

54.  H.P. Lang, Hegner M. and Gerber Ch. (2006) Microfabricated Cantilever Array Sensors for (Bio-) Chemical Detection in: Applied Scanning Probe Methods IV - Industrial Applications, B. Bhushan, H. Fuchs (Eds.), Springer Verlag (Berlin, New York, Heidelberg), Ch. 28, pp. 183-213 PDFNanomechanical detection of analytes - Overview

53.  H.P. Lang, Hegner M. and Gerber Ch. (2006) Nanomechanical Cantilever Array Sensors, in: Springer Handbook of Nanotechnology, 2nd edition, Springer Verlag (Berlin, New York, Heidelberg), Ch. 16, pp. 443-450 PDF 
General overview of nanomechanical sensing (devices, detection, analytes)


52.  Huber, F., Hegner, M., Gerber, Ch.,Guntherodt, H.J., Lang, H.P. (2005) Label free analysis of transcription factors using microcantilever arrays Biosens. Bioelectron. 21 (8) 1599 - 1605 PDF 
Transcription factors detected nanomechanically

51.  Lang, H.P., Hegner, M., Gerber, Ch. (2005) Cantilever array sensors Materials today 8, 30-36 PDF 
Cantilever Sensing Overview

50.  Gfeller, K.Y, Nugaeva, N., Hegner, M.* (2005) Rapid biosensor for the detection of selective growth of Escherichia coli Appl. Env. Microbiol. 71 (5): 2626-2631 PDF 
E.Coli antibiotic sensitivity and growth detection within 30 minutes

49.  Bertoncini, P., Schoenauer, R., Agarkova, I., Hegner, M., Perriard, J.-C., Guntherodt, H.-J. (2005) Study of the Mechanical Properties of Myomesin Proteins Using Dynamic Force SpectroscopyJ. Mol. Biol. 348 (5): 1127-1137 PDF 
Myomesin mechanics examined by SFM force spectroscopy

48.  Schoenauer, R., Bertoncini, P., Machaidze, G., Aebi, U., Perriard, J.C.*, Hegner, M.*, Agarkova, I. (2005) Myomesin is a molecular spring with adaptable elasticity J. Mol. Biol. 49 (2): 367-379 PDF 
Biological AFM force spectroscopy reveals Myomesin unfolding mechanics  

47.  Gfeller, K., Nugaeva, N., Hegner, M.* (2005) Micromechanical oscillators as rapid biosensors for the detection of active growth of Escherichia coli Biosens. Bioelectron. 21(3) 528-533 PDF 
E.Coli growth detection within 30 minutes

46.  Shahgaldian P., Pieles U, Hegner M. (2005) Enantioselective recognition of phenylalanine by a chiral amphiphilic macrocycle at the air-water interface: A copper-mediated mechanism Langmuir 21 (14): 6503-6507 PDF
Small molecule capturing with cyclodextrins

45.  Shahgaldian, P., Hegner, M., Pieles, U. (2005) A cyclodextrin Self-Assembled Monolayer (SAM) based surface plasmon resonance (SPR) sensor for enantioselective analysis of thyroxine J. Incl. Phenom. 53, 35-39 PDF 
SPR detection of small ligand binding

44.  Braun, T., Barwich, V., Ghatkesar, M.K., Bredekamp, A.H., Gerber, Ch., Hegner, M.*, Lang, H.P. (2005) Mass sensors for biomolecular detection in physiological environment Phys. Rev. E, 72, 031907, 1-9 PDF
Nanomechanical analysis of cantilever vibrating in liquids (Models, Experiments)

43.  Backmann, N., , Zahnd, Ch., Huber, F., Bietsch, A., Pluckthun, A., Lang, H.P., Guntherodt, H.J., Hegner, M.*, Gerber, Ch. (2005) A label-free immunosensor array using single-chain antibody fragments Proc. Natl. Acad. Sci. USA, 102 (41),14587-14592 PDF
Nanomechancal antibody-antigen detection - LOD surpassing SPR

42.  Nugaeva, N., Gfeller, K.Y., Backmann, N., Lang, H.P., Düggelin, M., Hegner, M. (2005) Nanomechanical cantilever array sensors for selective fungal immobilization and real-time growth detection Biosens. Bioelectron. 21, 849-856 PDF 
Microfungi capturing and growth detection 


41.  Engel, A. & Hegner, M.* (2004). Atomic Force Microscopy & Laser Tweezers. Physics meets Biology, in: Matter and Materials (Gompper, G., Kaupp, U.B., Dhont, J.K.G., Richter, D. Winkler, R.G., Ed.), 19, Forschungszentrum Jülich, Jülich

40.  Schwarzenbach, M.S., Reimann, P., Thommen, V., Hegner, M., Mumenthaler, M., Schwob, J., Guntherodt, H.J. (2004) Topological structure and chemical composition of inner surfaces of borosilicate vials PDA J. Pharm. Sci. Technol. 58 (3)169-175 PDF
Glass corrosion detected in Nanopure water by AFM and how to prevent that by oxidation

39.  Bietsch, A., Hegner, M., Lang, H.P., Gerber, C. (2004) Inkjet deposition of alkanethiolate monolayers and DNA oligonucleotides on gold: Evaluation of spot uniformity by wet etching Langmuir 20 (12): 5119-5122 PDFRapid and durable functionalization of interfaces for diagnostics  

38.  Bietsch, A., Zhang, J.Y., Hegner, M., Lang, H.P., Gerber, Ch.(2004) Rapid functionalization of cantilever array sensors by inkjet printing Nanotechnology 15 (8): 873-880 PDFInk-jet functionalization of sensors for gas and biological sensing

37.  Hegner, M.* (2004) The Basel NanoBio-Network Chimia 58, 788 - 791 PDF 
Teaching/Research network in the upper Rhine Valley (CH,D,F)

36.  Ghatkesar M. K., Barwich, V., Braun, T., Bredekamp, A.H., Drechsler, U., Despont, M., Lang, H. P., Hegner, M.*, Gerber Ch. (2004) RealTime Mass Sensing by Nanomechanical Resonators in Fluid Proc. IEEE Sensors 2004 1060 – 1063 PDF 
Dynamic mass measurement in liquid using cantilever arrays


35.  Hegner, M. * and Grange, W. (2003) Mechanics and imaging of single DNA molecules. J. Muscl. Res. Cell Mot. 23,367-375 PDF 
Overview on single dsDNA molecule manipulation with SFM and optical tweezers

34.  Arntz, Y., Seelig, J.E., Zhang, J., Lang, H.P., Hunziker, P., Ramseyer, J.P., Meyer, E., Hegner, M.*, and Gerber, Ch. (2003) A label-free protein assay based on a nanomechanical cantilever array Nanotechnology 14, 86-90 PDF
Nanomechanical diagnostic of Infaction proteins in liquids

33.  Hegner, M.* and Arntz, Y. (2003) Advanced Biosensing Using Micromechanical Cantilever Arrays Methods in Molecular Biology 24, 39-49 PDF 
Nanomechanical Biosensing with silicon sensor arrays

32.  Hegner, M.*, Grange, W. and Bertoncini, P. (2003) Measurement of Single Molecular Interactions by Dynamic Force Microscopy Methods in Molecular Biology 24, 369-382 PDF 
Force Spectroscopy on single molecules

31.  Hegner, M.*, Gerber, Ch., Arntz, Y., Zhang, J., Bertoncini, P., Husale, S., Lang, H.P. and Grange, W. (2003) Biological Single Molecule Applications and Advanced Biosensing J. Chrom. Lib. 68, 241 - 263. in Emerging Technologies in Protein and Genomic Material Analysis (G.A. Marko-Varga, P.L. Orozlan Eds.) PDF 
Review on single molecule applications and biosensing


30.  Schumakovitch, I., Grange, W., Strunz, T., Bertoncini, P., Guntherodt, H.-J. and Hegner M.* (2002) Temperature Dependence of Unbinding Forces between Complementary DNA Strands Biophys J. 82, 517-521 PDF 
Temperature dependent ssDNA force spectroscopy

29.  Schwarzenbach, M.S., Reimann, P., Thommen, V., Hegner, M., Mumenthaler, M., Schwob, J., Guntherodt, H.J. * (2002) Interferon alpha-2a interactions on glass vial surfaces measured by atomic force microscopy PDA J. Pharm. Sci. Technol. 56, 78-89 PDFInterferon adhesion on pharmaceitical glass vials 

28.  Grange, W., Husale, S., Guntherodt, H.-J. and Hegner, M. * (2002) Optical tweezers system measuring the change in light momentum flux Rev. Sci. Instr. 73, 2308 2316 PDF 
Counter propagating Optical Tweezers with a force maximum @ 180 pN

27.  Husale, S., Grange, W. and Hegner, M. * (2002) DNA Mechanics Affected by Small DNA Interacting Ligands Single Mol. 3 ,(2-3), 91-96 PDF 
dsDNA mechanics changed by DNA fluorescent stains 

26.  McKendry, R., Zhang, J., Arntz, Y., Strunz, T., Hegner, M., Lang, H.P. *, Baller, M.K., Certa, C., Meyer, E., Güntherodt, H.-J. and Gerber, C. (2002) Multiple label-free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array Proc. Natl. Acad. Sci. USA 99 (15), 9783–9788 PDF 
ssDNA hybridisation on Nanomechanical sensors. SNP detection

25.  Hegner M.* (2002) Optics - The light fantastic Nature 419 (6903): 126-127 PDF 
Comment on Bessel beam guided optical manipulations

24.  Lang, H.P. *, Hegner, M., Meyer, E and Gerber, C. (2002) Nanomechanics from atomic resolution to molecular recognition based on atomic force microscopy technology Nanotechnology 13, R29-R36 PDF
Nanomechanics sensing principle - Importance of differential sensing

23.  Hegner, M. * and Engel, A. (2002) Single Molecule Imaging and Manipulation Chimia 56, 506 - 514 PDF 

22.  Lang, H.P. *, Hegner, M., Gerber, C. (2002) Nanomechanics - The Link to Biology and Chemistry Chimia 56, 515 - 519 PDF


21.  Hegner M. * and Guntherodt, H.-J. (2001) Nanometer Scale Science and Technology - The impact of STM and AFM International School of Physics Enrico Fermi Volume 144, 1-40 PDF 

20.  Grange W., Strunz T., Schumakovitch I., Guntherodt, H.-J. and Hegner, M. * (2001) Molecular Recognition and Adhesion of Individual DNA Strands Studied by Dynamic Force Microscopy Single Mol. 2 (2), 75-78 PDFssDNA hybridization measured by SFM force spectroscopy 


19.  Hegner, M. * (2000) DNA Handles for Single Molecule Experiments Single Mol. 1 (2) 139-144 PDF 
Covalent immoblization of dsDNA strands onto polystyrene spheres for optical tweezerrs manipulation

18.  Strunz, T., Oroszlan, K., Schumakovitch, I., Guntherodt, H.-J. and Hegner M.* (2000) Model energy landscapes and the force-induced dissociation of ligand-receptor bonds Biophys. J. 79, 1206-1212 PDF
Force spectroscopy theory and experiment of single molecule dissosciation

17.  De Paris, R., Strunz, T., Oroszlan, K., Guntherodt, H.-J. and Hegner, M. * (2000) Force Spectroscopy and Dynamics of the Biotin-Avidin Bond Studied by Scanning Force Microscopy Single Mol. 1 (4) 285-290 PDF 


16.  Hegner, M., Smith, S.B. and Bustamante, C. (1999) Polymerization and mechanical properties of single RecA-DNA filaments Proc. Natl. Acad. Sci. USA 96 (18), 10109-10114 PDF
Optical tweezers experiment on single RecA filaments  (dsDNA -> ssDNA -> RecA filament)


15.  Hegner, M.* and Wagner, P. (1998) Ultraflat Au surfaces (TSG) for biological SPM applications, in: Procedures in Scanning Probe Microscopy, ed. Colton et al., Wiley & Sons Ltd. New York, 172-175 PDF
Detailed procedure to produce ultra-flat gold surfacees (rms<1nm) over um^2 

14.  Wagner, P. and Hegner, M. (1998) A general method for immobilizing biomolecules on gold for SPM in aqueous buffers, in: Procedures in Scanning Probe Microscopy, ed. Colton et al., Wiley & Sons Ltd. New York, 481-487 PDF 
Detailed procedures to anchor biological molecules covalently to gold interfaces 


13.  Hegner, M. *, Dreier, M., Wagner, P., Semenza, G. and Guntherodt, H.-J. (1996) Modified DNA immobilized on bioreactive self-assembled monolayer on gold for dynamic force microscopy imaging in aqueous buffer solution J. Vac. Sci. Technol. B, 14, 1418-1421 PDFEnd-modified dsDNA molecules anchored covalently to SAMs on gold for contact SFM 

12.  Dammer, U., Hegner, M. *, Anselmetti, D., Wagner, P., Dreier, M., Huber, W. and Guntherodt, H.J. (1996) Specific Antigen/Antibody interactions measured by Force Microscopy Biophys. J., 70, 2437-2441 PDF 
Force spectroscopy with antibody/antigen pairs - Nanomechanical insights

11.  Wagner, P. , Kernen, P., Zaugg, F., Hegner, M. and Semenza, G. (1996) omega-Functionalized self-assembled monolayers chemisorbed on ultraflat Au(111) surfaces for biological scanning probe microscopy in aqueous buffers J. Vac. Sci. Technol. B, 14, 1466-1471 PDF 
Contact SFM requires covalent anchoring of biomolecules during imaging in liquids 

10.  Wagner, P., Hegner, M., Kernen, P., Zaugg, F. and Semenza, G. (1996) N-hydroxysuccinimide ester functionalized self-assembled monolayers for covalent immobilization of biomolecules on gold Biophys. J., 70, 2052-2066 PDF 
Detailed study on formation -, reaction kinetics and anchoring biomolecules to SAM functionalised gold interfaces

9.  Weigert, S. , Dreier, M. and Hegner, M. (1996) Frequency shifts of cantilevers vibrating in various media Appl. Phys. Lett. 69, 2834-2836 PDF
Thoeretical consideration on co-moved masses of liquids during oscillations 


8.  Dammer, U., Anselmetti, D., Dreier, M., Hegner, M., Huber, W., Hurst, J., Misevic, G.N. and Guntherodt, H.J.  (1995) Measuring molecular adhesion with force microscopy Forces in SPM, NATO-ASI Serie E, Vol. 286, 625-632 PDF 
Biotin/Streptavidin dynamic force spectroscopy

7.  Wagner, P., Hegner, M., Guntherodt, H.-J. and Semenza, G. (1995) Formation and in-situ modification of monolayers chemisorbed on template-stripped gold surfaces for operations on nano-scale Langmuir,11, 3867-3875 PDF 
In-situ chemical activation of self-assembled monolayers on gold interfaces imged by SPM 


6.  Shelden, R.A. , Meier, L.P., Caseri, W.R., Suter, U.W., Hermann, R., Muller, M., Hegner, M. and Wagner, P. (1994) Nanophase molecular droplets: individual polystyrene molecules on mica imaged with scanning electron and atomic-force microscopy Polymer, 35, 1571-1575 PDF 
Nano-Polymer droplets on interfaces imaged by SPM 

5.  Wagner, P., Kernen, P., Hegner, M., Ungewickell, E. and Semenza, G.  (1994) Covalent anchoring of proteins onto gold-directed NHS-terminated self-assembled monolayers in aqueous buffers: SFM imaging of Clathrin and its cages FEBS Letters, 356, 267-271 PDF 
Clathrin cages and triskela imaged in liquids on gold surfaces by SPM 

4.  Dammer,U. und Hegner, M. (1994) Neue "Augen" für Biologen, UniNova 72/94, 38-40 PDF 
Biological Scanning Probe Microscopy Imaging 


3.  Hegner, M., Wagner, P. and Semenza, G. * (1993) Ultralarge atomically flat template-stripped Au surfaces for scanning probe microscopy Surface Science, 291, 39-46 PDF 
Ultraflat gold surfaces with rms < 1 nm over um^2 

2.  Hegner, M., Wagner, P. and Semenza, G. * (1993) Immobilizing DNA on gold via thiol modification for atomic force microscopy imaging in buffer solutions FEBS Letters, 336, 452-456 PDF
dsDNA strands imaged with contact SPM in liquids  


1.  Hegner, M., Kieckebusch-Gück A. v., Falchetto, R., James, P., Semenza, G. and Mantei, N.* (1992) Single amino acid substitutions can convert the uncleaved signal-anchor of sucrase-isomaltase to a cleaved signal sequence, J. Biol. Chem., 267, 16928-16933 PDF
Solubilising anchored membrane proteins by point motations in the stalk region - Leading to SNP cleaving