Professor Michael Monaghan

• Monaghan MG, Kroll S, Brucker SY, Schenke-Layland K, Enabling Multiphoton and Second Harmonic Generation Imaging in Paraffin-Embedded and Histologically Stained Sections., Tissue engineering. Part C, Methods, 22, (6), 2016, p517-23Journal Article, 2016, DOI
• Monaghan M.G, Holeiter M, Layland S.L, Schenke-Layland K, Cardiomyocyte generation from somatic sources " current status and future directions , Current Opinion in Biotechnology , 40, 2016, p49 - 55Journal Article, 2016, DOI
• Brauchle E, Knopf A, Bauer H, Shen N, Linder S, Monaghan MG, Ellwanger K, Layland SL, Brucker SY, Nsair A, Schenke-Layland K, Non-invasive Chamber-Specific Identification of Cardiomyocytes in Differentiating Pluripotent Stem Cells., Stem cell reports, 6, (2), 2016, p188-99Journal Article, 2016, DOI
• Monaghan MG, Linneweh M, Liebscher S, Van Handel B, Layland SL, Schenke-Layland K, Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development., Development (Cambridge, England), 143, (3), 2016, p473-82Journal Article, 2016, DOI
• Dash, B.C., Thomas, D., Monaghan, M., Carroll, O., Chen, X., Woodhouse, K., O'Brien, T., Pandit, A., An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia, Biomaterials, 65, 2015, p126-139Journal Article, 2015, DOI
• Groeber, F., Engelhardt, L., Egger, S., Werthmann, H., Monaghan, M., Walles, H., Hansmann, J., Impedance Spectroscopy for the Non-Destructive Evaluation of In Vitro Epidermal Models, Pharmaceutical Research, 32, (5), 2015, p1845-1854Journal Article, 2015, DOI
• Browne, S., Monaghan, M.G., Brauchle, E., Berrio, D.C., Chantepie, S., Papy-Garcia, D., Schenke-Layland, K., Pandit, A., Modulation of inflammation and angiogenesis and changes in ECM GAG-activity via dual delivery of nucleic acids, Biomaterials, 69, 2015, p133-147Journal Article, 2015, DOI
• Monaghan, Michael, Browne, Shane, Schenke-Layland, Katja, Pandit, Abhay, A Collagen-based Scaffold Delivering Exogenous MicroRNA-29B to Modulate Extracellular Matrix Remodeling, Molecular Therapy, 22, (4), 2014, p786-796Journal Article, 2014, DOI
• Monaghan, M., Augspurger, C., Brauchle, E., Lakner, P., Breunig, G., Konig, K., Schenke-Layland, K., Fluorescent live time imaging from pluripotency to differentiation in mouse embryonic stem cells reveals endogenous autofluorescence profiles, Journal of Tissue Engineering and Regenerative Medicine, 8, 2014, p300-301Journal Article, 2014, DOI
• Schesny, M.K., Monaghan, M., Bindermann, A.H., Freund, D., Seifert, M., Eble, J.A., Vogel, S., Gawaz, M.P., Hinderer, S., Schenke-Layland, K., Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels, Biomaterials, 35, (25), 2014, p7180-7187Journal Article, 2014, DOI
• Monaghan, M., Greiser, U., Wall, J.G., O'Brien, T., Pandit, A., Interference: An alteRNAtive therapy following acute myocardial infarction, Trends in Pharmacological Sciences, 33, (12), 2012, p635-645Journal Article, 2012, DOI
• Monaghan, M. Holladay, C. Pandit, A.(ed.), A crosslinked collagen type i biomaterial reservoir for non-viral gene delivery in vivo, 2011Proceedings of a Conference, 2011
• Monaghan, M., Pandit, A., RNA interference therapy via functionalized scaffolds, Advanced Drug Delivery Reviews, 63, (4), 2011, p197-208Journal Article, 2011, DOI
• Monaghan, M. Browne, S. Wang, W. Pandit, A.(ed.), Scaffold mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, 2011Proceedings of a Conference, 2011, URL
• Dash, B.C., Réthoré, G., Monaghan, M., Fitzgerald, K., Gallagher, W., Pandit, A., The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility, Biomaterials, 31, (32), 2010, p8188-8197Journal Article, 2010, DOI
• Lakner P.H*, Monaghan M. G*, M, Möller Y, Olayioye M.A, Schenke-Layland K. , Applying a phasor approach analysis of multiphoton fluorescence lifetime imaging microscopy measurements to probe the metabolic activity of three-dimensional in vitro cell culture models., Nature Scientific Reports, 7, 2017, p42730-Journal Article, 2017, DOI , TARA - Full Text
• Monaghan M, Greiser U, Cao H, Wang W, Pandit A, A ligand enhanced dendritic PEGylated poly (2-(dimethylamino) ethyl diacrylate) as a vehicle of microRNA, Drug Delivery and Translational Research, 2, 2011, p406 - 414Journal Article, 2011, DOI , URL
• Monaghan M.G, Holeiter M, Brauchle E, Layland S.L, Lu Y, Deb A, Pandit A, Nsair A, Schenke-Layland K, Exogenous miR-29B delivery via a hyaluronan-based injectable system yields functional maintenance of the infarcted myocardium, Tissue Engineering Part A, 24, 2018, p57 - 67Journal Article, 2018, DOI
• Michael Monaghan, An injectable collagen scaffold delivering exogenous microRNA as a therapy to modulate extracellular matrix remodelling , NUI Galway, 2013Thesis, 2013, URL
• Energy Regeneration systems in cell free protein synthesis in vitro in, editor(s)Bethaz C, Li Puma V , New Research on Protein Synthesis, Nova Science Publishers, Inc, 2013, pp67 - 76, [2. Kahlig A, Schwedhelm I, Monaghan M, Thein M, Hansmann J]Book Chapter, 2013, URL
• Optical reprogramming and opticalcharacterization of cells using femtosecond lasers in, editor(s)König K, Ostendorf A , Biomedical Applications in Optically-Induced Nanostructures for Biomedical and Technical Applications, De Gruyter , 2015, pp159 - 178, [1. Uchugonova A, Augspurger C, Monaghan M, Schenke-Layland K, Konig K]Book Chapter, 2015, URL
• Lakner P, Möller Y, Olayioye M, Brucker S.Y, Schenke-Layland K, Monaghan M.G., Multiphoton Microscopy in the Biomedical Sciences XVI, Proc SPIE9712, SPIE BioS Multiphoton Microscopy in the Biomedical Sciences XVI, San Francisco, 14th March 2016, edited by Ammasi Periasamy; Peter T. C. So; Karsten König , 2016, pp97120XConference Paper, 2016, DOI
• Lotz C, Schmid F.F, Oechsle E, Monaghan M, Walles H, Groeber-Becker F.K, A crosslinked collagen hydrogel matrix resisting contraction to facilitate full-thickness skin equivalents, ACS Appl. Mater. Interfaces, 9, 2017, p20417 - 20425Journal Article, 2017, DOI
• Shen N, Riedl JA, Carvajal-Berrio DA, Davis Z, Monaghan MG, Layland SL, Hinderer S, Schenke-Layland K. , A flow bioreactor system compatible with real-time two-photon fluorescence lifetime imaging microscopy., Biomedical Materials, 13, 2018, p024101-Journal Article, 2018, DOI
• Dolan, E.B. and Hofmann, B. and de Vaal, M.H. and Bellavia, G. and Straino, S. and Kovarova, L. and Pravda, M. and Velebny, V. and Daro, D. and Braun, N. and Monahan, D.S. and Levey, R.E. and O'Neill, H. and Hinderer, S. and Greensmith, R. and Monaghan, M.G. and Schenke-Layland, K. and Dockery, P. and Murphy, B.P. and Kelly, H.M. and Wildhirt, S. and Duffy, G.P., A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction, Materials Science and Engineering C, 103, (109751), 2019Journal Article, 2019, DOI , URL
• Ukkelman IA, Neto N, Papkovsky DB, Monaghan MG, Dmitriev RI., A deeper understanding of intestinal organoid metabolism revealed by combining fluorescence lifetime imaging microscopy (FLIM) and extracellular flux analyses., Redox biology, 30, 2020, p101420Journal Article, 2020, DOI , TARA - Full Text
• Solazzo M, Krukiewicz K, Zhussupbekova A, Fleischer K, Biggs MJ, Monaghan MG., PEDOT:PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility., J Mater Chem B, 7, (31), 2019, p4811-4820Journal Article, 2019, DOI , TARA - Full Text
• O'Rourke SA, Dunne A, Monaghan MG., The Role of Macrophages in the Infarcted Myocardium: Orchestrators of ECM Remodeling., Frontiers in cardiovascular medicine, 6, 2019, p101Journal Article, 2019, DOI , TARA - Full Text
• Solazzo M, O'Brien FJ, Nicolosi V, Monaghan MG., The rationale and emergence of electroconductive biomaterial scaffolds in cardiac tissue engineering., APL Bioeng, 3, (4), 2019, p041501Journal Article, 2019, DOI , TARA - Full Text
• Dolan E. B., Varela C. E., Mendez K., Whyte W., Levey R. E., Robinson S. T., Maye E., O†Dwyer J., Beatty R., Rothman A., Fan Y., Hochstein J., Rothenbucher S. E., Wylie R., Starr J. R., Monaghan M., Dockery P., Duffy G. P., Roche E. T., An actuatable soft reservoir modulates host foreign body response , Sci. Robotics , 4 , (33 ), 2019, peaax7043 -Journal Article, 2019, DOI , URL
• Olvera D., Sohrabi Molina M., Hendy G., Monaghan M.G., Electroconductive Melt Electrowritten Patches Matching the Mechanical Anisotropy of Human Myocardium, Advanced Functional Materials, 2020Journal Article, 2020, DOI , TARA - Full Text
• Ozaki, Ema, Gibbons, Luke, Neto, Nuno GB, Kenna, Paul, Carty, Michael, Humphries, Marian, Humphries, Pete, Campbell, Matthew, Monaghan, Michael, Bowie, Andrew and Doyle, Sarah L, SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration, Life Science Alliance, 3, (5), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Seeing Is Believing: Noninvasive Microscopic Imaging Modalities for Tissue Engineering and Regenerative Medicine in, editor(s)Heinz Redl, Jeff Gimble, Darja Marolt Presen, Richard Oreffo and Susanne Wolbank , Tissue Engineering and Regeneration. Cell Engineering and Regeneration, Switzerland, Springer, 2020, ppAccepted- - In Press, [Neto N, Dmitriev R, Monaghan MG]Book Chapter, 2020
• Extrusion-based additive manufacturing techniques for biomedical applications in, editor(s)Dermot Brabazon , Encyclopedia of Materials: Composites, Philadelphia, Elsevier, 2020, ppIn Press - [Tadayyon G, Kelly DJ, Monaghan MG]Book Chapter, 2020
• Olvera D, Monaghan MG, Electroactive biomaterial-based biosensors for detection and drug delivery , Advanced Drug Delivery Reviews, 2020Journal Article, 2020
• Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U., Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint., JCI insight, 5, (21), 2020Journal Article, 2020, DOI
• Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael G. Monaghan, Resident macrophages and their potential in cardiac tissue engineering, Tissue Engineering Part B Reviews, 2021Journal Article, 2021, TARA - Full Text
• Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021Journal Article, 2021, DOI
• Perottoni S, Neto NGB, Di Nitto C, Dmitriev RI, Raimondi MT, Monaghan MG., Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip., Lab on a chip, 21, (7), 2021, p1395-1408Journal Article, 2021, DOI
• Solazzo M, Monaghan MG., Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications., Biomaterials science, 9, (12), 2021, p4317-4328Journal Article, 2021, DOI
• Old Drugs, New Tricks - Redefining Therapeutic Strategies For Tissue Regeneration., Advanced Drug Delivery Reviews- Elsevier, 2021, -Critical Edition (Chapter), 2021, DOI
• Saha, Uttariyo, Nairn, Rory, Keenan, Orla, Monaghan, Michael G., A Deeper Insight into the Influence of the Electric Field Strength When Melt"Electrowriting on Non"Planar Surfaces, Macromolecular Materials and Engineering, 2021, p2100496Journal Article, 2021, DOI
• Coulter, Fergal B., Levey, Ruth E., Robinson, Scott T., Dolan, Eimear B., Deotti, Stefano, Monaghan, Michael, Dockery, Peter, Coulter, Brian S., Burke, Liam P., Lowery, Aoife J., Beatty, Rachel, Paetzold, Ryan, Prendergast, James J., Bellavia, Gabriella, Straino, Stefania, Cianfarani, Francesca, Salamone, Monica, Bruno, Carmelo M., Moerman, Kevin M., Ghersi, Giulio, Duffy, Garry P., O'Cearbhaill, Eoin D., Soft Tissue Implants: Additive Manufacturing of Multi"Scale Porous Soft Tissue Implants That Encourage Vascularization and Tissue Ingrowth (Adv. Healthcare Mater. 14/2021), Advanced Healthcare Materials, 10, (14), 2021, p2170063Journal Article, 2021, DOI
• O'Rourke S., Dunne A., Monaghan, M.G, The Influence of Electroconductive Materials on Macrophage Phenotype, 25th Bioengineering in Ireland 2019, Limerick, Ireland, 2019Oral Presentation, 2019
• Solazzo, M., Zhussupbekova A., Krukiewicz K., Fleisher K., Biggs M. J. P., Monaghan, M. G, Minimally invasive 3D electroconductive biomaterial platforms for cardiac tissue engineering applications, Tissue Engineering and Regenerative Medicine International Society (TERMIS) EU Chapter meeting, Rhodes, Greece, 27- 31st of May, 2019Oral Presentation, 2019
• Solazzo, M., Wong S., Zhussupbekova A., Krukiewicz K., Fleisher K., Biggs M. J. P., Monaghan, M. G. , Engineered electroconductive biomaterial platforms for cardiac tissue engineering applications, Sir Bernard Crossland Symposium 2019, Belfast, 17-18th April, 2019Oral Presentation, 2019
• Solazzo, M.*, Monaghan, M. G, Minimally invasive 3D electroconductive biomaterial platforms for cardiac tissue engineering applications, 25th Bioengineering in Ireland 2019, Limerick, Ireland, 18-19th January, 2019Oral Presentation, 2019
• Solazzo, M., Monaghan, M. G, An electroconductive 3D porous PEDOT:PSS scaffold for cardiac tissue engineering applications, 24th Bioengineering in Ireland 2018, Dublin, 26-27th January, 2018Oral Presentation, 2018
• Neto N., O'Rourke S., Zhang M., Dunne A., Monaghan M, Single-cell metabolic profiling of macrophage polarization by fluorescence lifetime imaging microscopy (FLIM), 6th European Congress for Immunology Meeting, Online, 1-4th September, 2021Oral Presentation, 2021
• Perottoni S.*, Neto N., di Nitto C., Dmitriev R., Raimoundi M.T., Monaghan M, ., Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip, European Society for Biomechanics, Milan, Italy (and online), 11-14th July, 2021Oral Presentation, 2021
• Perottoni S.*, Neto N., di Nitto C., Dmitriev R., Raimoundi M.T., Monaghan M, Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip, European Society for Biomechanics, Milan, Italy (and online), 11-14th July, 2021Oral Presentation, 2021
• Neto N., Perottoni S., di Nitto C., Dmitriev R., Raimoundi M.T., Monaghan M, ., Intracellular label-free detection of mesenchymal stem cell metabolism within a perivascular niche-on-a-chip, Termis Workshop: Cell-Matrix Interaction and Mechanobiology in Regenerative Medicine, Online, 11-12th June, 2021Oral Presentation, 2021
• Floudas A., Neto N., Vivianna M., Murray K., Moran B., Monaghan M., Candice L., Mullan R.H., Krishna V., Nagpal S., Veale D.J., Fearon U, Pathogenic, Glycolitic PD-1+ cells accumulate in the Hypoxic RA joint, 8th Annual Meeting of the International Cytokine and Interferon Society, Seattle, USA, 1-4th November 2020, 2020Oral Presentation, 2020
• Neto N., Greaney C., Olvera D., Duffy C., Hoey D., Monaghan M.G, Discerning the Effect of Substrate directed differentiation on Mesenchymal Stromal Cell Metabolic Activity using FLIM, Matrix Biology Ireland Galway Meeting, Galway, Ireland, 21st November , 2018Oral Presentation, 2018
• Neto N., Greaney C., Olvera D., Duffy C., Hoey D., Monaghan M.G, Discerning the Effect of Substrate directed differentiation on Mesenchymal Stromal Cell Metabolic Activity using FLIM, 25th Bioengineering in Ireland 2019, , Limerick Ireland, 18-19th January, 2019Oral Presentation, 2019
• Lakner P, Möller Y, Olayioye M, Brucker S.Y, Schenke-Layland K, Monaghan, M.G, A Phasor approach analysis of multiphoton FLIM measurements of three-dimensional cell culture models, SPIE Photonics West meeting , San Francisco, USA, 13-18th February , 2016Oral Presentation, 2016
• Molina-Arce C, Brauchle E, Monaghan M.G, Holeiter M, Schenke-Layland K. , Characterization of extracellular matrix in murine scar tissues with near infrared Raman microspectroscopy, Innovation Match MX, Guadalajara, Mexico, 6-8th April , 2016Oral Presentation, 2016
• Monaghan M, Brauchle E, Carvajal Berrio D, Deb A, Pandit A, Nsair A, Schenke-Layland K, Biomaterial delivery of exogenous miR-29b to the infarcted myocardium yields improved myocardial recovery, the World Congress of the Tissue Engineering and Regenerative Medicine International Society, Boston, MA, USA, 8-11th September , 2015Oral Presentation, 2015
• Maurer M, Monaghan M, Möller Y, Olayioye M, Schenke-Layland K, Single-cell transfection within a 3D tumor model using optoporation, Biomedical Engineering Society Annual Meeting, San Antonio, Texas, USA, 22-25th October, 2014Oral Presentation, 2014
• Monaghan M, Browne S, Schenke-Layland K, Pandit A, A Collagen-based Scaffold Delivering Exogenous microRNA-29B to Modulate Extracellular Matrix Remodeling , Meeting of the German Matrix Biology Society (DGMB), Regensburg, Germany, 20-24th March , 2014Oral Presentation, 2014
• Monaghan M, Browne S, Wang W, Pandit A, Delivery and efficacy of interfering RNA via a crosslinked collagen hydrogel in an excisional in vivo model and a human pre‐clinical model to reduce fibrosis, World Congress of Tissue Engineering and Regenerative Medicine International Society, Vienna, Austria, 5-8th September, 2012Oral Presentation, 2012
• Monaghan M, Browne S, Wang W, Pandit A, Delivery and efficacy of interfering RNA via a crosslinked collagen hydrogel in an excisional in vivo model and a human pre‐clinical model to reduce fibrosis, 3rd International Conference , Wurzburg, Germany, 23-25th May, 2012Oral Presentation, 2012
• Monaghan M, Browne S, Wang W, Pandit A, Scaffold-mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, European Society of Biomaterials Conference, Dublin, Ireland, 4-9th September , 2011Oral Presentation, 2011
• Kelly J.L, Doody J, Zeugolis D, Monaghan M, Kelly G, Devocelle M, Kilcoyne M, Joshi L, Pandit A, Collagen fibers modified with polysialic mimetic peptide are a suitable material for use as a synthetic peripheral nerve graft, Irish Association of Plastic Surgery Meeting, Dublin, IReland, 26th November, 2010Oral Presentation, 2010
• Dash B.C, Mahor S, Monaghan M, Woodhouse K.A, Pandit A, Elastin like protein based hollow spheres for gene delivery, European Society of Biomaterials Conference, Tampere, Finland, 11-15th September, 2010Oral Presentation, 2010
• Monaghan M, Mathew A, Greiser U, Wang W, Pandit A, Scaffold mediated delivery of microRNA immunopolyplexes, European Society of Biomaterials Conference, Tampere, Finland, 11-15th September, 2010Oral Presentation, 2010
• Monaghan M, Mathew A, Greiser U, Wang W, Pandit A, Scaffold mediated delivery of microRNA immunopolyplexes, Tissue Engineering and Regenerative Medicine Conference, Galway, Ireland, 14-17th June, 2010Oral Presentation, 2010
• Dash B C, Mahor S, Monaghan M, Woodhouse K A, Pandit A, Elastin like protein based hollow spheres for gene delivery, Tissue Engineering and Regenerative Medicine Conference, Galway, Ireland, 14-17th June, 2010Oral Presentation, 2010
• Mathew A, Monaghan M, Wang W, Pandit A. , A linear-dendritic hybrid poly (2-(dimethylamino) ethyl methacrylate) as a highly effective gene delivery vector, the European Society of Biomaterials Conference, Tampere, Finland, 11-15th September, 2010Oral Presentation, 2010
• Réthoré G, Monaghan M, Dash B C, Pandit A, Chitosan-polyglutamic acid biodegradable nanospheres show a blood compatibility response that is dictated by size and surface charge, 2nd World Congress of the Tissue Engineering and Regenerative Medicine International Society, Seoul, Republic of Korea, 11-15th September, 2009Oral Presentation, 2009
• Matthew A, Réthoré G, Dash B C, Monaghan M, Pandit, A, Chitosan/polyglutamic acid nanospheres: DNA encapsulation and release, cellular uptake and blood interaction studies, UK Society for Biomaterials Conference, Antrim, UK, 2009Oral Presentation, 2009
• Fitzgerald H., Williams D. G., Campbell N. K., Barry P, O'Rourke S. A. Neto N., Monaghan M. G., Nolan D. P., Dunne A, Aromatic ketoacids represent novel therapies for autoimmune diseases through activation of the Nrf2/HO-1 pathway and suppression of pro-inflammatory responses in primary human immune cells, British Society for Immunology 2021 Congress, Edinburgh, 30th November, 2021Meeting Abstract, 2021
• Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, British Society for Immunology 2021 Congress, Edinburgh, 30th November, 2021Meeting Abstract, 2021
• ORourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, Targeting metabolism in cardiovascular disease: investigating metabolic reprogramming of macrophages in atherosclerosis as a novel therapeutic strategy, British Society for Immunology 2021 Congress, Edinburgh, 30th November, 2021Meeting Abstract, 2021
• Fitzgerald, H.K.; O'Rourke, S.A.; Desmond, E.; Neto, N.G.B.; Monaghan, M.G.; Tosetto, M.; Doherty, J.; Ryan, E.J.; Doherty, G.A.; Nolan, D.P.; Fletcher, J.M.; Dunne, A, The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells, Antioxidants, 11, 2022, p164-Journal Article, 2022, DOI
• Floudas A, Gorman A, Neto N, Monaghan MG, Elliott Z, Fearon U, Marzaioli V., Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis., Frontiers in medicine, 9, 2022, p830998Journal Article, 2022, DOI
• Nuno Neto, Sinead O'Rourke, Mimi Zhang, Hannah Fitzgerald, Aisling Dunne and Michael Monaghan, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, eLife, 11, 2022, pe77373Journal Article, 2022
• Mary Rooney, Nuno Neto, Michael Monaghan, Emmeline Hill, Richard K. Porter, Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis, Biochemistry and Biophysics Reports, 2022Journal Article, 2022
• Solazzo, Matteo, Hartzell, Linette, O"Farrell, Ciara, Monaghan, Michael G., Beyond Chemistry: Tailoring Stiffness and Microarchitecture to Engineer Highly Sensitive Biphasic Elastomeric Piezoresistive Sensors, ACS Applied Materials & Interfaces, 14, (17), 2022, p19265-19277Journal Article, 2022, DOI
• Leikeim, Anna, Wußmann, Maximiliane, Schmidt, Freia F., Neto, Nuno G. B., Benz, Franziska, Tiltmann, Kendra, Junger, Corinna, Monaghan, Michael G., Schilling, Bastian, Groeber-Becker, Florian K., A preclinical model of cutaneous melanoma based on reconstructed human epidermis, Scientific Reports, 12, (1), 2022Journal Article, 2022, DOI
• Solazzo, Matteo, Monaghan, Michael G., Hydrophilic, conductive and flexible piezoresistive PEDOT:PSS 3D sensors with tunable microarchitecture and crosslinked using a PEGylated crosslinker, Synthetic Metals, 290, 2022, p117157Journal Article, 2022, DOI
• O"Rourke S., Solazzo M., Dunne A., Monaghan M.G, External delivery of electrical stimulation promotes M2 macrophage polarisation: Implications in regenerative tissue engineering, Trinity Centre for Biomedical Engineering Annual Research Day. , TCD, Dublin, 6th of December 2022, 2022Conference Paper, 2022
• Lianne Shanley, Olwyn Mahon, Sinead O'Rourke, Nuno Neto, Michael Monaghan, Daniel Kelly, Aisling Dunne, PARTICLE SIZE ALTERS MACROPHAGE METABOLISM: IMPLICATIONS FOR BONE TISSUE ENGINEERING, Irish Society for Immunology 2022 Annual Meeting, Maynooth, Co. Kildare, 1-2nd September 2022, 2022Conference Paper, 2022
• Sinead A. O'Rourke, Nuno G.B. Neto, Eimear Devilly, Lianne C Shanley, Hannah K Fitzgerald, Michael G Monaghan, Aisling Dunne, INVESTIGATING METABOLIC REPROGRAMMING OF MACROPHAGES AS A NOVEL THERAPEUTIC STRATEGY FOR ATHEROSCLEROSIS, Irish Society for Immunology 2022 Annual Meeting, Maynooth, Co. Kildare, 1-2nd September 2022, 2022Meeting Abstract, 2022
• Monaghan MG, Crosslinked extracellular matrix biomaterials functionalized with 2D-nanomaterial MXenes for cardiac tissue engineering drive iPSC-derived cardiomyocyte maturation, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester. UK, March 2023, 2023Conference Paper, 2023
• Monaghan MG, Non-invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, March 2023, 2023Conference Paper, 2023
• Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael Monaghan, Functional cardiac organoids modeling the inflammatory environment of myocardial infarction , Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Manchester, UK, March 2023, 2023Conference Paper, 2023
• Nuno G.B. Neto, Sinead O"Rourke, Mimi Zhang, Hannah Fitzgerald, Aisling Dunne, Michael Monaghan, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Microscopy Society of Ireland 2022 Meeting, Galway, Ireland, 2022Conference Paper, 2022
• Michael Monaghan, Machine Learning Optimization, Prediction and Smart Design for Biomaterial Scaffolds Using Melt-Electrowriting, Biofabrication 2022- International Society for Biofabrication Meeting, Montecatini Terme, Italy, September 2022, 2022Invited Talk, 2022
• Leahy, L.M., Woods, I., Gutierrez-Gonzalez, J., Monaghan, M. G, Dervan, A. O"Brien, F.J, DEVELOPMENT OF AN ELECTROCONDUCTIVE, 3D-PRINTED SCAFFOLD DESIGNED TO PROMOTE AXONAL REGROWTH AFTER SPINAL CORD INJURY, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022Conference Paper, 2022
• Leahy, L.M. Woods, I., Gutierrez-Gonzalez, J, Monaghan, M. G, Dervan, A., O"Brien, F.J., DEVELOPMENT OF AN ELECTROCONDUCTIVE, 3D-PRINTED SCAFFOLD DESIGNED TO PROMOTE AXONAL REGROWTH AFTER SPINAL CORD INJURY, European Society for Biomaterials Annual Meeting 2022, Bordeaux, France, September 2022, 2022Conference Paper, 2022
• Michael Monaghan, Optimization, Prediction and Smart Design for Anisotropically and Mechanically Matching Biomaterial Scaffolds Using Melt-Electrowriting, Gordon Research Conference: Bioinspired Materials, Les Diablerets, Switzerland, June 2022, 2022Conference Paper, 2022
• Solazzo M, Monaghan MG, ELECTROCONDUCTIVE SCAFFOLDS FOR IN VITRO CARDIAC MODELS, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022Conference Paper, 2022
• Monaghan MG, Non-Invasive classification of macrophage polarisation by 2P-FLIM and machine learning, Meeting of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society, Krakow, Poland, July 2022, 2022Conference Paper, 2022
• Shanley, L.C. and Mahon, O.R. and O'Rourke, S.A. and Neto, N.G.B. and Monaghan, M.G. and Kelly, D.J. and Dunne, A., Macrophage metabolic profile is altered by hydroxyapatite particle size, Acta Biomaterialia, 2023Journal Article, 2023, DOI , URL
• Chariyev-Prinz, F. and Szojka, A. and Neto, N. and Burdis, R. and Monaghan, M.G. and Kelly, D.J., An assessment of the response of human MSCs to hydrostatic pressure in environments supportive of differential chondrogenesis, Journal of Biomechanics, 154, (111590), 2023Journal Article, 2023, DOI , URL
• Chariyev-Prinz, F. and Neto, N. and Monaghan, M.G. and Kelly, D.J., Time-Dependent Anabolic Response of hMSC-Derived Cartilage Grafts to Hydrostatic Pressure, Journal of Tissue Engineering and Regenerative Medicine, 2023, (9976121), 2023Journal Article, 2023, DOI , URL
• Asaro G.A, Solazzo M, Suku M, Spurling D, Genoud K, Gonzalez J.G, Brien F.J.O, Nicolosi V, Monaghan M.G, MXene functionalized collagen biomaterials for cardiac tissue engineering driving iPSC-derived cardiomyocyte maturation, npj 2D Materials and Applications, 7, (1), 2023Journal Article, 2023
• Monaghan M.G., Borah R., Thomsen C., Browne S., Thou shall not heal: Overcoming the non-healing behaviour of diabetic foot ulcers by engineering the inflammatory microenvironment, Advanced Drug Delivery Reviews, 203, 2023Journal Article, 2023, DOI
• Barroso M., Monaghan M.G., Niesner R., Dmitriev R.I., Probing organoid metabolism using fluorescence lifetime imaging microscopy (FLIM): The next frontier of drug discovery and disease understanding, Advanced Drug Delivery Reviews, 201, 2023Journal Article, 2023, DOI
• Solazzo M., Monaghan M.G., A Workflow to Produce a Low-Cost In Vitro Platform for the Electric-Field Pacing of Cellularised 3D Porous Scaffolds, ACS Biomaterials Science and Engineering, 9, (8), 2023, p4573 - 4582, p4573-4582Journal Article, 2023, DOI
• Darroch C., Asaro G.A., Greant C., Suku M., Pien N., van Vlierberghe S., Monaghan M.G., Melt electrowriting of a biocompatible photo-crosslinkable poly(D,L-lactic acid)/poly("-caprolactone)-based material with tunable mechanical and functionalization properties, Journal of Biomedical Materials Research - Part A, 111, (6), 2023, p851 - 862, p851-862Journal Article, 2023, DOI
• Michael Monaghan, Bioelectricity, 2D Nanomaterials and Conductive Polymers for Tissue Engineering, Tissue Engineering and Regenerative Medicine International Society 2023 Annual Meeting, Manchester, UK, 28-31st March 2023, 2023, Local Organising Committee of the TERMIS Conference, ManchesterInvited Talk, 2023
• Michael Monaghan, Non-invasive classification of macrophage polarisation by 2P-FLIM and machine, Tissue Engineering and Regenerative Medicine International Society 2023 EU Meeting, Manchester, UK, 28-31st March 2023, 2023, Local Organising Committee of the 2023 TERMIS EU Meeting, ManchesterInvited Talk, 2023
• Michael Monaghan, Conductive Biomaterials for Tissue Engineering- Application of Conductive Polymers and 2D Nanomaterials, World Biomaterials Congress, Daegu, South Korea, 26-31st May 2024, 2024, World Biomaterials Congress Scientific Advisory CommitteeInvited Talk, 2024
• Michael Monaghan, Engineering innate immunology in cardiovascular disease models and regenerative medicine, Gordon Research Conference: Immunoengineering, Renaissance Tuscany Il Ciocco, Italy, 11-16th Feb 2024, 2024Poster, 2024
• Rajiv Borah, Meenakshi Suku, Michael Monaghan,, Fabrication and characterization of Indian non-mulberry silk based electroconductive hydrogel with tunable mechanical property and biodegradability, UK Society of Biomaterials Conference 2023, Belfast, UK, 20-21 June, 2023, 2023Oral Presentation, 2023
• Rajiv Borah, Meenakshi Suku, Michael Monaghan, Silk based electroconductive biomaterials for nerve cell stimulation, Gordon Research Conference on Silk Proteins and the Transition to Biotechnologies, Bryant University, Smithfield, Rhode Island, United States, 9-14 July, 2023, 2023Oral Presentation, 2023
• Rajiv Borah, Daniel Diez Clarke, Meenakshi Suku, Michael Monaghan,, RGD enriched Indian non-mulberry silk-based injectable electroconductive hydrogels for potential spinal cord repair, RGD enriched Indian non-mulberry silk-based injectable electroconductive hydrogels for potential spinal cord repair, Gordon Research Conference on Silk Proteins and the Transition to Biotechnologies,, 9-14 July, 2023, 2023Invited Talk, 2023
• Rajiv Borah, Daniel Diez Clarke, Meenakshi Suku, Michael Monaghan, 3D bioprinting of a versatile neural stem cell laden silk based electroconductive hydrogel scaffold for spinal cord repair, Additive Manufacturing for Health, , CCI Nantes St-Nazaire Les Salons d"Affaires " Centre des Salorges, France, 21-22 March, 2024,, 2024Oral Presentation, 2024
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG,, Functional cardiac organoids modeling the inflammatory environment of myocardial infarction, Tissue Engineering and Regenerative Medicine International Society- 2023 EU Meeting, Manchester, UK, 28-31st March 2023, 2023Oral Presentation, 2023
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG, Engineering innate immunology in a humanized, functional, in vitro model of healthy myocardium, Gordon Research Seminar in Biomaterials and Tissue Engineering, Holderness, New Hampshire, USA, July 15th 2023, 2023, Gordon Research Seminar CommitteeInvited Talk, 2023
• Asaro. GA, Solazzo. M, Suku. M*, Spurling. D, Genoud. K, Gonzalez. JG, O'Brien. FJ, Nicolosi. V, Monaghan. MG, Crosslinked extracellular matrix biomaterials functionalized with 2D-nanomaterial MXenes for cardiac tissue engineering drive iPSC-derived cardiomyocyte maturation, Tissue Engineering and Regenerative Medicine International Society (TERMIS) - 2023 EU Meeting, Manchester, UK, 28-31st March 2023, 2023Poster, 2023
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG, Development of humanized, functional, tissue engineered in vitro model of healthy myocardium, Gordon Research Conference in Biomaterials and Tissue Engineering, Honderness, New Hampshire, USA, 16-21st July 2023, 2023Poster, 2023
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG, Engineering innate immunology in a humanized, functional, in vitro model of healthy myocardium, Gordon Research Seminar in Immunoengineering, Lucca, Italy, 10th February 2024, 2024Oral Presentation, 2024
• Neto, N.G.B., Suku, M., Hoey, D.A, Monaghan, M.G, 2P-FLIM unveils time-dependent metabolic shifts during osteogenic differentiation with a key role of lactate to fuel osteogenesis via glutaminolysis identified, Stem Cell Res Ther, 14, (364), 2023Journal Article, 2023
• O'Rourke SA, Neto NGB, Devilly E, Shanley LC, Fitzgerald HK, Monaghan MG*, Dunne A.*, Cholesterol crystals drive metabolic reprogramming and M1 macrophage polarisation in primary human macrophages, Atherosclerosis, 352, 2022, p35 - 45Journal Article, 2022, DOI

• Michael Monaghan, Non-invasive, nonlinear microscopy in the evaluation of extracellular matrix and cell metabolic activity, ORS Musculoskeletal Summer Symposium, Dublin, 6-7th July, 2017, Dvid HoeyInvited Talk
• O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, 6th European Congress for Immunology Meeting, Online, 1-4th September , 2021Meeting Abstract
• Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021Meeting Abstract
• Shanley L., Mahon O. R., O'Rourke S. A., Neto N., Monaghan M. G., Kelly D., Dunne A, Particle size alters macrophage metabolism: Implications for bone tissue engineering, 6th European Congress for Immunology Meeting, Online, 1-4th September , 2021Meeting Abstract
• O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, ., Immunometabolism in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, 34th Conference of the European Macrophage and Dendritic Cell Society, Online, 24-25th June , 2021Meeting Abstract
• Fitzgerald H., Williams D. G., Campbell N. K., Barry P, O'Rourke S. A. Neto N., Monaghan M. G., Nolan D. P., Dunne A, Trypanosoma brucei secreted aromatic ketoacids activate the Nrf2/HO-1 pathway and suppress pro-inflammatory responses in primary murine and human immune cells, . 34th Conference of the European Macrophage and Dendritic Cell Society. Virtual conference , Online, 24-25th June, 2021Meeting Abstract
• O'Rourke S., Neto N., Devilly E., Shanley L., Dunne A., Monaghan M. G, Inflammation in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, Termis Workshop: Cell-Matrix Interaction and Mechanobiology in Regenerative Medicine, Online, 11-12th June, 2021Oral Presentation
• O'Rourke S., Neto N., Dunne A., Monaghan M. G., , Immune modulation in atherosclerosis: Investigating cholesterol crystals as potent drivers of metabolic reprogramming and M1 macrophage polarisation, Drexel Immune Modulation and Engineering Symposium, , Philadelphia, U.S.A, 11-13th November , 2020Oral Presentation
• Neto N, O'Rourke S., Vishwanathan A., Dunne A., O'Farrelly C., Monaghan M. G., , Metabolic Profiling of Macrophage Polarization by Fluorescence Lifetime Imaging Microscopy, Immunometabolism Symposium, Dublin, 5th April , 2019Oral Presentation
• Solazzo, M.*. Monaghan, M. G, Engineered electroconductive biomaterial platforms for cardiac tissue engineering applications, TBSI Research Symposium 2019, Dublin, 4th September , 2019Oral Presentation
• Suku. M., Forrester. L., Biggs. M, Monaghan, M. G, Tuning of Macrophage Polarization in the generation of functional cardiac organoids, EPSRC-SFI Joint Student Day, Online, 7th September, 2021Oral Presentation
• Monaghan M, Browne S, Wang W, Pandit A, Scaffold-mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, World Conference in Regenerative Medicine, Leipzig, Germany, 2-4th November, 2012Oral Presentation
• Monaghan M, Pandit A, Development of a 3D co-culture model to interpret the biological response of vascular biomaterials in vitro, , National Centre for Biomedical Engineering Science Research Day, Galway, Ireland, Galway, Ireland, March , 2008Meeting Abstract
• Sara Corbezzolo, Meenakshi Suku, Locke Davenport Huyer, Milica Radisic Michael G. Monaghan, Melt electrowriting of synclastically curved patches compensating the mechanical anisotropy of the infarcted myocardium, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield, Ireland, January 2023, 2023Conference Paper
• Meenakshi Suku, Lesley Forrester, Manus Biggs, Michael Monaghan, Tuning macrophage polarization to model myocardial infarction in the generation of functional cardiac organoids, 28th Annual Conference of the section of Bioengineering of the Royal Academy of Medicine in Ireland, Enfield Ireland, January 2023, 2023Conference Paper
• Michael Monaghan, Engineering Non-invasive Tools to Profile Cell Metabolism in Differentiation and Disease, Tissue and Cell Engineering Society (TCES) Annual Meeting (joint with the EPSRC Funded Centres for Doctoral Training, Birmingham, UK, 14th June 2022, 2022Invited Talk
• Michael Monaghan, MXene and Conductive Polymers for Tissue Engineering, Ghent Bioengineering Research Seminar, Ghent, Belgium , October 2022, 2022, Ruslan DmitrievInvited Talk
• Monaghan Michael, MXene and Conductive Polymers in Tissue Engineering, Joint 2D Nanomaterials meeting between RCD and Royal College of Surgeons in Ireland, RCSI, Dublin, Ireland, October 2022, 2022Invited Talk
• Monaghan MG, ELectroconductive Biomaterial Patches and Scaffolds to Match the Mechanical Anisotropy of Organ-specific Tissues, Beacon Mini Symposium, Ireland-Canada University Foundation, Online, 2021, 2021Invited Talk
• Monaghan MG, Applying novel design and non-invasive investigations to advance the fields of tissue engineering and optics, School of Pharmacy Seminar Series at TCD, Virtual, 2020, 2020, School of Pharmacy, TCDInvited Talk
• Michael Monaghan, Conductive Biomaterials for Tissue Engineering- Application of Conductive Polymers and 2D Nanomaterials, Ghent University Biomedical Seminar Series, Online, 24th October 2023, 2023, Ruslan DmitrievInvited Talk
• Michael Monaghan, Non-Invasive cell characterisation by 2P-FLIM and machine learning, Core Technologies in the Life Sciences 2023 Congress, Croke Park, Dublin, Ireland, 27-29th June 2023, 2023, CORE TECHNOLOGIES FOR LIFE SCIENCESInvited Talk
• Michael Monaghan, Non-Invasive classification of stem cell differentiation and macrophage polarisation by 2P-FLIM and machine learning, Center for Translational Medicine at the International Clinical Research Center of St. Anne"s University Hospital in Brno, Czech Republic Seminar Series, Brno, Czech Republic, 31st May 2023, 2023, Prof Giancarlo ForteInvited Talk
• Michael Monaghan, Non-Invasive classification of stem cell differentiation and macrophage polarisation by 2P-FLIM and machine learning, Dublin City University School of Biotechnology Seminar Series, DCU, Dublin, Ireland, 5th April 2023, 2023, Dr Achilleas FloudasInvited Talk
• Michael Monaghan, Conductive Biomaterials for Tissue Engineering- Application of Conductive Polymers and 2D Nanomaterials, Annual Division C conference at Cambridge University, Cambridge University, Cambridge, UK, 23rd March 2023, 2023, Division C Committee-Department of EngineeringInvited Talk
• Rajiv Borah, Daniel Diez Clarke, Meenakshi Suku, Julia O'Sullivan, Maeve Caldwell, Michael Monaghan,, In situ forming mulberry silk based electroconductive hydrogel for spinal cord repair, 4th International meeting of BioBrillouin, Dublin, Ireland, 6-8th December 2023, 2023Poster
• Rajiv Borah, Daniel Diez Clarke, Meenakshi Suku, Julia O'Sullivan, Maeve Caldwell, Michael Monaghan, In situ forming non-mulberry silk based electroconductive hydrogel for spinal cord repair, Trinity Centre for Biomedical Engineering Research Day, Dublin, IReland, 11th December 2023, 2023Poster
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG,, Development of humanized, functional, tissue engineered in vitro model of healthy myocardium, CÚRAM "Organ-on-a-Chip/Organoids" Meeting, Online, 23rd June 2023, 2023, CURAM- SFI Centre for Medical DevicesInvited Talk
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG, Development of humanized, functional, tissue engineered in vitro model of healthy myocardium, International BioBrillouin Meeting 2023, Dublin Ireland, 6-8th December 2023, 2023Poster
• Suku. M, Forrester. L, Biggs. M, Monaghan. MG, Engineering innate immunology in a humanized, functional, in vitro model of healthy myocardium, Gordon Research Conference in Immunoengineering, Lucca, Italy, 11th February 2024, 2024Poster
• Corbezzolo S., Meenakshi S., Davenport Huyer L., Radisic M., Monaghan M.G, Melt electrowriting of synclastically curved patches compensating the mechanical anisotropy of the infarcted myocardium, BioEngineering In Ireland Annual Meeting, Enfield, Meath, Ireland., 27-28th January 2023, 2023Oral Presentation
• Corbezzolo S., Meenakshi S., Davenport Huyer L., Radisic M., Monaghan M.G, Melt electrowriting of synclastically curved patches compensating the mechanical anisotropy of the infarcted myocardium, International BioBrillouin Meeting, Dublin, Ireland, 6-8th December 2023, 2023Poster
• Corbezzolo S., Meenakshi S., Davenport Huyer L., Radisic M., Monaghan M.G.,, Melt electrowriting of synclastically curved patches compensating the mechanical anisotropy of the infarcted myocardium, Inaugural School of Engineering Research Symposium, TCD, Dublin, 26th October 2023, 2023Poster

The focus of the Monaghan lab (www.monaghanlab.com) is the development of novel biomaterial design-based strategies to regenerate or repair damaged tissues and restore biomechanical function using informed and optimised design approaches. Core Research Areas: . Cardiac tissue engineering and cell derivitisation from multi/pluripotent stem cell sources . Macrophage assessment and inclusion in advanced biomaterial culture platforms. . In silico predictive modelling and optimisation of biomaterial geometries . Electroconductive biomaterial synthesis, fabrication and applications . Advanced non-linear microscopy using multiphoton microscopy for non-invasive imaging of extracellular matrix . Advanced fluoresecent lifetime imaging microscopy (FLIM) in the assessment of cellular metabolism during disease, differentiation and regeneration. . Melt-electrowriting development, optimisation and application Our lab is leading new approaches for biomaterial fabrication and design using advanced biomaterials, tissue engineering, biofabrication and in silico predictive modelling. This workis creating a paradigm shift in which the scientific community, industry partners and clinical investigators approach biomaterial design. Our lab is recognised internationally as world class where we am regularly invited to deliver keynote talks at major international meetings, and our papers have received awards for being most downloaded in our field. Members of the team have also been awarded prizes at national/international level in recognition of the scientific quality of our labs work. I have coordinated and elevated the Med3DP initiative over the past five years (www.med3dp.com) which develops medical devices for healthcare using 3D printing technology, demonstrating research led teaching and student led learning. Our lab also has collaborative funding with small-medium enterprises such as Spraybase® (Bioprinting; next generation implantable devices) and I am a funded investigator in the SFI funded centres AMBER and CURAM. My work spans across and engages with several disciplines which includes Physics and Chemistry, Computer Science, Biochemistry and Immunology, Pharmacy, Surgery, Oncology and Endocrinology. This is strongly reflective in our illustrious repertoire of publications. Link to Google Scholar: https://scholar.google.com/citations?user=X1mgIbEAAAAJ&hl=en&oi=sra

• Title

  Development of minimally invasive neuromodulatory electroconductive hydrogel in combination with physical stimuli for spinal cord regeneration
  Summary

  Spinal cord injury (SCI) is a debilitating health conditions affecting circa 27.04 million people globally including 6.4 million Europeans with serious impact on the quality of life and socio-economic status of the patients. Existing regenerative and rehabilitation approaches are largely palliative and neuroprotective, targeting the spared neural tissue after injury with limited efficacy in regeneration. While the spinal cord has poor regenerative ability, the degenerative processes further complicate the SCI pathophysiology. Hence, no regenerative and rehabilitation approaches, individually, have resulted in complete and near complete functional recovery to date. To fully restore the injured spinal cord's functionality, a coordinated combinational approach addressing particular degenerative processes is necessary. Herein, the fellow proposes to develop a regenerative rehabilitation combinational approach to maximize the functional regenerative outcome after SCI using minimally invasive injectable electroconductive hydrogels (ECHs) functionalized with neurotrophins (NTs) and anti-inflammatory cytokines in combination with electrical stimulation (ES) and near infrared (NIR) laser stimulation. ES and NIR laser through the ECH will be used to stimulate the neurons and glial cells to enhance regeneration and neuroplasticity as well as for on demand delivery of biologics to target the inhibitory processes. This proposal describes the project's multidisciplinary nature, execution and management of the project by the fellow and the multiple collaborators who will each provide the fellow with cutting-edge research skills. The goals of the fellow's project place specific focus to ensure that the training of the fellow brings him to a level of competitive scientific excellence at international level.
  Funding Agency

  European Commission
  Date From

  September 2021
  Date To

  August 2023
• Title

  PiezoMac
  Summary

  Piezoceutical biomaterial scaffolds for immunomodulatory-based myocardial repair
  Funding Agency

  European Commission
• Title

  Coordination Support - ERC version
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  April 2022
  Date To

  March 2023
• Title

  Doctoral Network for a Shared Excellence of Fluorescent Lifetime Imaging Microscopy in Biomedical Applications
  Summary

  In flIMAGIN3D, which centres on fluorescent lifetime imaging microscopy applied to biomedical platforms in 3D; ten talented Doctoral Candidates (DCs) will be recruited, trained and supervised to cohesively establish the most robust, user accessible and powerful FLIM-based platform-never achieved before, and apply it to a wide range of applications in the biological sciences. flIMAGIN3D will generate ten DCs)at the cutting edge of FLIM-based biological imaging who will spearhead, and go onto catalyse clusters of FLIM excellence across Europe; each intertwined within a collaborative network that will extend beyond the time-frame of the program. This doctoral network will train talented doctoral candidates in the essential theories underpinning FLIM , and through the individual projects and extensive secondments in this network; elevate their projects and skills, and that of their secondment hosts to research excellence in FLIM flIMAGIN3D addresses a significant knowledge gap in the field of photonics in biology by involving biomedical scientists in each and every aspect of development and design, and cognisant of the wide variety of current platforms that require adaptability to such modalities. In flIMAGIN3D: bringing together representatives with different applications and backgrounds, we will identify and overcome barriers to FLIM imaging by developing the next generation of scientists who will develop a FLIM platform capable of extracting the greatest amount of information possible in a stream-lined, accurate and user-friendly manner in order to understand biology in disease, differentiation, development and interventions at a high resolution. To achieve this goal, the trained scientists will develop cheaper advanced hardware components, with user friendly software that can build precise libraries for accurate machine learning classifications and plug-and-play platforms and sensors to facilitate a wide range of applications.
  Funding Agency

  European Commission
  Date From

  January 2023
  Date To

  December 2026
• Title

  Comparative analysis of induced pluripotent stem cell-derived cardiac cells with their human counterparts
  Summary
  Funding Agency

  European Molecular Biology Organisation (EMBO)
• Title

  The role of macrophage polarization in the generation of functional engineered mature myocardium organoids
  Summary

  It is the purpose of this PhD project to intertwine the fields of bioengineering, biochemistry and immunology, by combining macrophages; key cells of the innate immune system, with cardiac organoids to achieve a more physiologically relevant model and achieve a diseased 'heart-attack-on-a-dish' organoid model as a patient specific pharmacological testing platform.
  Funding Agency

  Trinity College Dublin Faculty of Engineering Maths and Sciences Intrafaculty PhD College Award
  Date From

  September 2018
  Date To

  August 2022
• Title

  Cell-Specific Metabolic FLIM Profiling of the Ulcerative Colitis Microenvironment to Establish an Association with Patient Treatment Response
  Summary

  Non-invasive FLIM could reliably establish a statistically significant relationship between the FLIM characteristics of UC biopsies and UC patient response. The specific aims of this research project are to employ FLIM to characterise the microenvironment of lesions in UC. This includes measurement of the mean fluorescent decay times, contributing lifetimes and ratios of NADH and FAD within cellular populations dominating the UC microenvironment in a spatio-temporal manner. This will pave the way towards launching a FLIM imaging core facility that can reliably categorise cell specific metabolic profiles within tissue biopsies from patients diagnosed with UC, and provide recommendations for treatment regimens.
  Funding Agency

  Trinity College Dublin Provosts PhD Project Award
  Date From

  September 2018
  Date To

  August 2022
• Title

  Zebrisome: : Regeneration Permissive Matrisome From Zebra Fish Heart For Cardiac Healing After Heart Attack
  Summary
  Funding Agency

  MSCA-COFUND (EU Commission and SFI Centre CURAM for Medical Devices)
• Title

  Recapitulating electrical, mechanical and extracellular-matrix cues via multifunctional biomaterials to engineer cardiac tissue
  Summary
  Funding Agency

  SFI-HRB-Wellcome Trust
  Date From

  January 2017
  Date To

  Septebmer 2019
• Title

  Enhancement of an Olympus FV1000MPE multiphoton microscope in Trinity Biomedical Sciences Institute (TBSI) for the application of Fluorescent Lifetime Imaging Microscopy (FLIM)
  Summary

  Enhancement of an Olympus FV1000MPE multiphoton microscope in Trinity Biomedical Sciences Institute (TBSI) for the application of Fluorescent Lifetime Imaging Microscopy (FLIM)
  Funding Agency

  SFI Funding internally allocated by TCD
  Date From

  01-Feb-17
  Date To

  N/a
• Title

  Engineering Innate Immunometabolism in the Maturation of in vitro Cardiac Models
  Summary
  Funding Agency

  Naughton Foundation
  Date From

  1st September 2023
  Date To

  31st August 2025
• Title

  Tuning macrophage polarization to model myocardial infarction in the generation of functional cardiac organoids'
  Summary

  It is the purpose of this PhD project to intertwine the fields of bioengineering, biochemistry and immunology, by combining macrophages; key cells of the innate immune system, with cardiac organoids to achieve a more physiologically relevant model and achieve a diseased 'heart-attack-on-a-dish' organoid model as a patient specific pharmacological testing platform. The generation of cardiac organoids can be achieved by recapitulating, as close as possible, the native microenvironment of the myocardium. Therefore, conductive polymers have gained interest as biomaterials for cardiac tissue engineering due to their suitable conductivity properties4. Very few reports have explored the interaction of macrophages and electroconductive biomaterials, and there are no reports regarding their introduction into cardiac organoids, or recapitulation of disease in a dish models
  Funding Agency

  EPSRC-SFI Joint Funding
  Date From

  01-Oct-19
  Date To

  31-Sep-23
• Title

  Materials in Tissue Engineering
  Summary
  Funding Agency

  International Association for the Exchange of Students for Technical Experience (IAESTE)
  Date From

  01/06/2019
  Date To

  31/08/2019
• Title

  Research Boost Program
  Summary
  Funding Agency

  TCD Dean of Research
  Date From

  November 2020
  Date To

  September 2021
• Title

  bioBRILLOUIN EI Support
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  July 2022
  Date To

  Dec 2022
• Title

  Resist-AMR Antimicrobial Resistance: Engineering Natural, One- Health, Systems Thinking Solutions to a Manmade Global Disaster
  Summary

  Antimicrobials are critical resources for human, animal and plant health. With emergence of antimicrobial resistance and lack of new antimicrobials, we face an unprecedented global environmental, food security and human health threat. Applying a multidisciplinary approach, the team including 4 PhD projects and expertise from plant scientists, clinical and environmental microbiologists, geneticists, antimicrobial resistance specialists, computer scientists/statisticians, bioengineers and sociologists, will study environmental and human `resistomes" from agricultural and clinical settings and analyse agricultural stakeholders" practices and policies to identify institutional reform implications.
  Funding Agency

  TCD Alumni
  Date From

  March 2023
  Date To

  Feb 2027
• Title

  Engineering animal-free accurate models of the annulus fibrosis in vitro using morphometrical data applied to the 4D deposition of melt electrowritten fibres to achieve true anisotropy and lamellar orientations
  Summary

  Disease and debilitation of the intervertebral disc poses enormous burden on patient quality life and a significant cost in terms of clinical and economy costs. Tissue engineering is one promising approach to develop therapies for the intervertebral disc but requires the use of animal models to capture the mechanical environment of the intervertebral disc. This project will engineer, and 3D print an accurate in vitro model of the intervertebral disc and benchmark it with ex vivo ovine models which are standardly used in the field. This 3D printing technology offers a superior approach to achieve this; melt electrowriting will accurately capture the ellipsoidal geometry and alternating lamellar orientation of the annulus fibrosis. We will optimise the design and fabrication of this model using melt electrowriting and verify its suitability using mechanical testing and in vitro compatibility testing using human and sheep cells of the intervertebral disc. This approach will lead to the establishment of accurate in vitro models to optimise therapies of the intervertebral disc, minimise our reliance on animal models and lead to more `human-specific" models.
  Funding Agency

  Irish Research Council
  Date From

  Sept 2022
  Date To

  Dec 2023
• Title

  Feasibility and scope of PEDOT:PSS dry electrodes for Connected Health: Monitoring Fitness and Wellbeing"
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  Dec 2022
  Date To

  May 2023
• Title

  CardiacEire: An Ireland-centered approach unifying stakeholders in research to address cardiac disease in young people
  Summary

  Sudden Adult Death Syndrome (SADS) is an event that devastates communities and families, often without any warning. Given the devastation of this disease whereby seemingly young healthy individuals die suddenly; there is a strong drive both nationally and internationally to uncover the causes of this, particularly when heart failure is the cause. Specific causes of heart-related SADS are known , however there is still much more to be done. This proposal aims to gather all interested parties in Ireland, from research labs, the clinic, affected families and governmental policy-makers to have a unified approach as international players addressing this disease.
  Funding Agency

  Irish Research Council- New Foundations
• Title

  Conductive materials for regeneration of the infarcted myocardium
  Summary

  Every sixth man and seventh woman will die from a heart attack or related complications Heart attacks lead to the death of functional cells in heart muscle (cardiomyocytes; CMs) which cannot be replaced. CMs in vivo are exposed to a unique environment defined by the local extracellular matrix (ECM), dynamic mechanical forces via the beating of the heart and electrical action potentials being generated by the heart's electrical conduction system. Electroconductive biomaterials in heart tissue engineering have the potential to be a building block for advanced therapeutic medical devices and also to achieve functional cardiac tissue in vitro. This project is a unique materials engineering approach to develop a cardio-inductive platform based on mechanical, electrical and ECM cues to generate the next generation of biomaterials. This research aims to generate the following outcome: a cardio-inductive biomaterial system derived from advanced nanomaterials that has appropriate mechanical, electroconductive and biocompatibility properties that can facilitate the generation of cardiac organoids in vitro using primary cells and efficiently facilitate cardiomyogenic differentiation from progenitor cells. These advances will not only improve quality of life for patients, but also provide tools to study disease and perform pharmaceutical research. This PhD program will develop a 3D biomaterial scaffold using synthetic nanomaterials together with naturally derived ECM that is biocompatible, suitably electroconductive and cardio-inductive towards facilitating the culture of cardiac organoids in vitro and enhancing stem cell cardiomyogenesis in vitro. Methods will include materials chemical characterisation techniques, cell culture, biochemical assays, mechanical testing, stem cell culture, immunohistochemistry, instrumentation. Support and training are provided throughout all stages.
  Funding Agency

  SFI
  Date From

  01-Oct-19
  Date To

  31-Sep-23
• Title

  3D Electroconductive biomaterial scaffolds as cardioinductive matrices for cardiac tissue engineering
  Summary

  Heart attacks lead to the death of functional cells in heart muscle (cardiomyocytes; CMs) which cannot be replaced. Every sixth man and seventh woman will die from a heart attack or related complications, and there is no way to regenerate this heart muscle. CMs in vivo are exposed to a unique environment defined by the local extracellular matrix (ECM), dynamic mechanical forces via the beating of the heart and electrical action potentials being generated by the heart's electrical conduction system. This proposal is a unique engineering approach to recapitulate a cardio-inductive platform based on mechanical, electrical and ECM cues to generate an efficient culture system to culture CMs in vitro and also to increase efficiencies of generating functional CMs from progenitor cells. This research aims to generate the following outcome: a cardio-inductive biomaterial system that has appropriate mechanical electroconductive and biocompatibility properties that can facilitate the generation of cardiac organoids in vitro using primary cells and efficiently facilitate cardiomyogenic differentiation from progenitor cells. These advances will not only improve quality of life for the patient but provide tools to study disease and perform pharmaceutical research.
  Funding Agency

  Irish Research Council
  Date From

  01-SEP-19
  Date To

  31-AUG-21
• Title

  Enabling Melt ElectroWriting of Electroconductive, Geometrically Defined 3D Biomaterials to Promote the Maturation of Cardiomyocytes for Cardiac Regeneration
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  December 2017
  Date To

  January 2020

Polymer science, Medical, Health and Life Sciences & Technologies, Materials Science, Medical, Health and Life Sciences & Technologies, Regenerative and Developmental Biology, Photonics, sensing and imaging, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics), Photonics, sensing and imaging, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics), Materials Science, Polymer science, Regenerative and Developmental Biology, Biochemistry, Molecular & Cellular Biology, Chemical sciences & engineering, Biochemistry, Molecular & Cellular Biology, Chemical sciences & engineering,

• European Doctoral Award, Issued by the European Society of Biomaterials 2015
• Nominated 'One to Watch' Trinity Innovation Awards 2021
• Senior author on paper awarded 1st prize in the in the Regenerative Medicine track section at the Bioengineering in Ireland Conference, Enfield, Ireland. Awarded to Meenakshi Suku, 2023. 2023
• Senior author on paper awarded the 'Engineers Ireland Biomedical Research Medal' from the Society of Engineers Ireland. Awarded to Dr Matteo Solazzo 2022
• European Research Council (ERC) Consolidator Grant [PiezoMac] 2023
• University Scholar (Based on end of term results) NUI Galway 2005
• Roche Best Poster Award, NCBES Research day 2008
• Naughton Foundation Faculty Fellowship 2023
• The Robert Brown Early Career Investigator Award- Issued by the EU Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2023
• EMBO Short Term Travel Award to conduct research in Fraunhofer IGB Stuttgart 2011
• Deutscher Akademischer Austausch Dienst, Short Term Travel Award to conduct research in University Hospital Tübingen 2012
• NUI Galway College of Engineering and Informatics Research Fellow 2007

• ESB- European Society for Biomaterials Present
• MBI- Matrix Biology Ireland (elected council member and Society Treasurer) Present
• Funded Investigator: SFI Funded Centre CÚRAM (Designing The Next Generation of 'Smart' Medical Devices) Present
• TERMIS - Tissue Engineering and Regenerative Medicine Society Present
• Funded Investigator: SFI Funded Centre AMBER (Advanced Materials and BioEngineering Research) Present
• DGMB-German Matrix Biology Society 2016
• Royal Academy of Medicine in Ireland (RAMI)- Bioengineering Section Present
• International BioBrillouin Society Present

• Elected Treasurer- Matrix Biology Ireland 2017 Meeting 30 Nov 2016
• International BioBrillouin Society: Board Member 1st June 2023
• Elected Council Member -Tissue Engineering and Regenerative Medicine International Society (EU Chapter) 01-Jan-2018
• Elected Council Member -Tissue Engineering and Regenerative Medicine International Society (EU Chapter) 01-Jan-2018
• External Examiner PhD Thesis Progress- Royal College of Surgeons in Ireland 2017
• Reviewer for leading journals in the fields of Biomaterials and Tissue Engineering (selection only): Biomaterials, RSC Biomaterials Science, Advanced Optical Materials, ACS Biomaterials Science and Engineering, Macromolecular Materials and Engineering, Small, Macromolecular Bioscience, Advanced Functional Materials, Advanced NanoBiomed Research, Advanced Materials Technologies, Journal of Controlled Release, Molecular Therapy, Advanced Healthcare Materials, Tissue Engineering Part A, Tissue Engineering Part B, Acta Biomaterialia, ACS Applied Materials and Interfaces, Advanced Drug Delivery Reviews, Lab on a Chip, Nature Scientific Reports, Journal of Tissue Engineering and Regenerative Medicine, npj 2D Materials and Applications 2015-Present
• Elected Treasurer- Matrix Biology Ireland 2017 Meeting 30 Nov 2016
• Grant Reviewer for National and International Granting Bodies Including: European Research Council ADVANCED GRANTS European Research Council Starting Grants Wellcome Trust (2020-Present) MRC-AMED Regenerative Medicine and Stem Cell Research Initiative (2020- Present) Israel Science Foundation (2020-Present) Marie Sklowdowska-Curie Individual Fellowships (2019-Present) Freiburg Institute for Advanced Studies Deutsche Forschungsgemeinschaft (DFG) (2029-Present) Canada Foundation for Innovation (CFI) through the John R. Evans Leaders Fund (2021) 2018