Predisposition to accidental awareness under anaesthesia identified

Posted on: 12 January 2023

New markers in brain structures and function could help identify people who require a higher than average dose of anaesthetic.

Predisposition to accidental awareness under anaesthesia identified


Brain structures which could predict an individual’s predisposition to accidental awareness under anaesthetic have been identified for the first time by neuroscientists in Trinity College Dublin.

The findings, just published in the journal Human Brain Mapping, could help identify individuals who may require higher than average doses of anaesthetic.

Although anaesthesia has been used in clinical medicine for over 150, scientists do not fully understand why its effect on people is so varied. One in four patients presumed to be unconscious during general anaesthesia may in fact have subjective experiences, such as dreaming, and in very rare cases (0.05–0.2%) individuals become accidentally aware during a medical procedure.

The research found that one in three participants were unaffected by moderate propofol sedation in their response times, thus thwarting a key aim of anaesthesia—the suppression of behavioural responsiveness.

The research also showed, for the first time, that the participants who were resistant to anaesthesia had fundamental differences in the function and structures of the fronto-parietal regions of the brain to those who remained fully unconscious. Crucially, these brain differences could be predicted prior to sedation.

Lorina Naci, Associate Professor of Psychology, Trinity and lead author on the paper said:

“The detection of a person’s responsiveness to anaesthesia prior to sedation has important implications for patient safety and wellbeing. Our results highlight new markers for improving the monitoring of awareness during clinical anaesthesia. Although rare, accidental awareness during an operation can be very traumatic and lead to negative long-term health outcomes, such as post-traumatic stress disorder, as well as clinical depression or phobias.

“Our results suggest that individuals with larger grey matter volume in the frontal regions and stronger functional connectivity within fronto-parietal brain networks, may require higher doses of propofol to become nonresponsive compared to individuals with weaker connectivity and smaller grey matter volume in these regions.”

The research, conducted in Ireland and Canada, investigated 17 healthy individuals who were sedated with propofol, the most common clinical anaesthetic agent. The participants’ response time to detect a simple sound was measured when they were awake and as they became sedated. Brain activity of 25 participants as they listened to a simple story in both states was also measured.

The full paper, ‘Responsiveness variability during anaesthesia relates to inherent differences in brain structure and function of the fronto-parietal networks’, Deng F, Taylor N, Owen AM, Cusack R, Naci L*, Human Brain Mapping, can be viewed at this link


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