Medicine

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Professor Maeve Lowery

Professor Maeve Lowery

Prof. of Translational Cancer Medicine, Surgery


Biography

Professor Maeve Lowery is Professor of Translational Cancer Medicine at Trinity College Dublin and Consultant Medical Oncologist at St James Hospital. Professor Lowery is chairperson of the Cancer Molecular Diagnostics Advisory Group of the National Cancer Control Program (NCCP). Her clinical and translational research involves design and conduction of clinical trials in patients with gastrointestinal malignancies, incorporating translational study endpoints to validate predictive and prognostic biomarkers, identify mechanisms of resistance and guide the development of rational therapeutic strategies. Her translational research interests use of real time genomic profiling to identify novel therapeutic strategies for gastrointestinal cancers, identification of non coding alterations as modifiers of the DNA damage response pathway and generation of organoid models of cancer as a tool for precision oncology as a member of the PRECODE consortium. Her work is supported by the Pancreatic Cancer Research Fund (https://www.pcrf.org.uk), Science Foundation Ireland, through the Precision Oncology Ireland Consortium and the EU Horizon 2020 Marie Sklodowska-Curie Programme.

Publications and Further Research Outputs

  • , A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model., Translational oncology, 2017Journal Article, 2017
  • , Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing., JAMA, 2017Journal Article, 2017
  • , A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma., Cancer, 2017Journal Article, 2017
  • , Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017Journal Article, 2017
  • , OncoKB: A Precision Oncology Knowledge Base., JCO precision oncology, 2017Journal Article, 2017
  • , Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype., Clinical cancer research : an official journal of the American Association for Cancer Research, 2017Journal Article, 2017
  • , Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017Journal Article, 2017
  • , Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer., Acta oncologica (Stockholm, Sweden), 2017Journal Article, 2017
  • , Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes., Journal of the American College of Surgeons, 2017Journal Article, 2017
  • , In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models., Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2017Journal Article, 2017
  • Lowery, M.A., Yu, K.H., Kelsen, D.P., Harding, J.J., Bomalaski, J.S., Glassman, D.C., Covington, C.M., Brenner, R., Hollywood, E., Barba, A., Johnston, A., Liu, K.C.-W., Feng, X., Capanu, M., Abou-Alfa, G.K., O'Reilly, E.M., A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma, Cancer, 2017Journal Article, 2017
  • Russell, J., Pillarsetty, N., Kramer, R.M., Romesser, P.B., Desai, P., Haimovitz-Friedman, A., Lowery, M.A., Humm, J.L., In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2"-deoxy-2"-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models, Molecular Imaging and Biology, 2017, p1-8Journal Article, 2017
  • Mandelker, D., Zhang, L., Kemel, Y., Stadler, Z.K., Joseph, V., Zehir, A., Pradhan, N., Arnold, A., Walsh, M.F., Li, Y., Balakrishnan, A.R., Syed, A., Prasad, M., Nafa, K., Carlo, M.I., Cadoo, K.A., Sheehan, M., Fleischut, M.H., Salo-Mullen, E., Trottier, M., Lipkin, S.M., Lincoln, A., Mukherjee, S., Ravichandran, V., Cambria, R., Galle, J., Abida, W., Arcila, M.E., Benayed, R., Shah, R., Yu, K., Bajorin, D.F., Coleman, J.A., Leach, S.D., Lowery, M.A., Garcia-Aguilar, J., Kantoff, P., Sawyers, C.L., Dickler, M.N., Saltz, L., Motzer, R.J., O'Reilly, E.M., Scher, H.I., Baselga, J., Klimstra, D.S., Solit, D.B., Hyman, D.M., Berger, M.F., Ladanyi, M., Robson, M.E., Offit, K., Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing, JAMA - Journal of the American Medical Association, 318, (9), 2017, p825-835Journal Article, 2017
  • Zehir, A., Benayed, R., Shah, R.H., Syed, A., Middha, S., Kim, H.R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S.M., Hellmann, M.D., Barron, D.A., Schram, A.M., Hameed, M., Dogan, S., Ross, D.S., Hechtman, J.F., DeLair, D.F., Yao, J., Mandelker, D.L., Cheng, D.T., Chandramohan, R., Mohanty, A.S., Ptashkin, R.N., Jayakumaran, G., Prasad, M., Syed, M.H., Rema, A.B., Liu, Z.Y., Nafa, K., Borsu, L., Sadowska, J., Casanova, J., Bacares, R., Kiecka, I.J., Razumova, A., Son, J.B., Stewart, L., Baldi, T., Mullaney, K.A., Al-Ahmadie, H., Vakiani, E., Abeshouse, A.A., Penson, A.V., Jonsson, P., Camacho, N., Chang, M.T., Won, H.H., Gross, B.E., Kundra, R., Heins, Z.J., Chen, H.-W., Phillips, S., Zhang, H., Wang, J., Ochoa, A., Wills, J., Eubank, M., Thomas, S.B., Gardos, S.M., Reales, D.N., Galle, J., Durany, R., Cambria, R., Abida, W., Cercek, A., Feldman, D.R., Gounder, M.M., Hakimi, A.A., Harding, J.J., Iyer, G., Janjigian, Y.Y., Jordan, E.J., Kelly, C.M., Lowery, M.A., Morris, L.G.T., Omuro, A.M., Raj, N., Razavi, P., Shoushtari, A.N., Shukla, N., Soumerai, T.E., Varghese, A.M., Yaeger, R., Coleman, J., Bochner, B., Riely, G.J., Saltz, L.B., Scher, H.I., Sabbatini, P.J., Robson, M.E., Klimstra, D.S., Taylor, B.S., Baselga, J., Schultz, N., Hyman, D.M., Arcila, M.E., Solit, D.B., Ladanyi, M., Berger, M.F., Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients, Nature Medicine, 23, (6), 2017, p703-713Journal Article, 2017
  • Park, J.J., Hajj, C., Reyngold, M., Shi, W., Zhang, Z., Cuaron, J.J., Crane, C.H., O"Reilly, E.M., Lowery, M.A., Yu, K.H., Goodman, K.A., Wu, A.J., Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer, Acta Oncologica, 2017, p1-8Journal Article, 2017
  • Creasy, J.M., Goldman, D.A., Dudeja, V., Lowery, M.A., Cercek, A., Balachandran, V.P., Allen, P.J., DeMatteo, R.P., Kingham, T.P., D'Angelica, M.I., Jarnagin, W.R., Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes, Journal of the American College of Surgeons, 224, (5), 2017, p906-916Journal Article, 2017
  • , A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model., Translational oncology, 2017Journal Article, 2017
  • , Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing., JAMA, 2017Journal Article, 2017
  • , A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma., Cancer, 2017Journal Article, 2017
  • , Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017Journal Article, 2017
  • , OncoKB: A Precision Oncology Knowledge Base., JCO precision oncology, 2017Journal Article, 2017
  • , Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype., Clinical cancer research : an official journal of the American Association for Cancer Research, 2017Journal Article, 2017
  • , Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017Journal Article, 2017
  • , Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer., Acta oncologica (Stockholm, Sweden), 2017Journal Article, 2017
  • , Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes., Journal of the American College of Surgeons, 2017Journal Article, 2017
  • , In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models., Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2017Journal Article, 2017
  • Lowery, M.A., Yu, K.H., Kelsen, D.P., Harding, J.J., Bomalaski, J.S., Glassman, D.C., Covington, C.M., Brenner, R., Hollywood, E., Barba, A., Johnston, A., Liu, K.C.-W., Feng, X., Capanu, M., Abou-Alfa, G.K., O'Reilly, E.M., A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma, Cancer, 2017Journal Article, 2017
  • Russell, J., Pillarsetty, N., Kramer, R.M., Romesser, P.B., Desai, P., Haimovitz-Friedman, A., Lowery, M.A., Humm, J.L., In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2"-deoxy-2"-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models, Molecular Imaging and Biology, 2017, p1-8Journal Article, 2017
  • Mandelker, D., Zhang, L., Kemel, Y., Stadler, Z.K., Joseph, V., Zehir, A., Pradhan, N., Arnold, A., Walsh, M.F., Li, Y., Balakrishnan, A.R., Syed, A., Prasad, M., Nafa, K., Carlo, M.I., Cadoo, K.A., Sheehan, M., Fleischut, M.H., Salo-Mullen, E., Trottier, M., Lipkin, S.M., Lincoln, A., Mukherjee, S., Ravichandran, V., Cambria, R., Galle, J., Abida, W., Arcila, M.E., Benayed, R., Shah, R., Yu, K., Bajorin, D.F., Coleman, J.A., Leach, S.D., Lowery, M.A., Garcia-Aguilar, J., Kantoff, P., Sawyers, C.L., Dickler, M.N., Saltz, L., Motzer, R.J., O'Reilly, E.M., Scher, H.I., Baselga, J., Klimstra, D.S., Solit, D.B., Hyman, D.M., Berger, M.F., Ladanyi, M., Robson, M.E., Offit, K., Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing, JAMA - Journal of the American Medical Association, 318, (9), 2017, p825-835Journal Article, 2017
  • Zehir, A., Benayed, R., Shah, R.H., Syed, A., Middha, S., Kim, H.R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S.M., Hellmann, M.D., Barron, D.A., Schram, A.M., Hameed, M., Dogan, S., Ross, D.S., Hechtman, J.F., DeLair, D.F., Yao, J., Mandelker, D.L., Cheng, D.T., Chandramohan, R., Mohanty, A.S., Ptashkin, R.N., Jayakumaran, G., Prasad, M., Syed, M.H., Rema, A.B., Liu, Z.Y., Nafa, K., Borsu, L., Sadowska, J., Casanova, J., Bacares, R., Kiecka, I.J., Razumova, A., Son, J.B., Stewart, L., Baldi, T., Mullaney, K.A., Al-Ahmadie, H., Vakiani, E., Abeshouse, A.A., Penson, A.V., Jonsson, P., Camacho, N., Chang, M.T., Won, H.H., Gross, B.E., Kundra, R., Heins, Z.J., Chen, H.-W., Phillips, S., Zhang, H., Wang, J., Ochoa, A., Wills, J., Eubank, M., Thomas, S.B., Gardos, S.M., Reales, D.N., Galle, J., Durany, R., Cambria, R., Abida, W., Cercek, A., Feldman, D.R., Gounder, M.M., Hakimi, A.A., Harding, J.J., Iyer, G., Janjigian, Y.Y., Jordan, E.J., Kelly, C.M., Lowery, M.A., Morris, L.G.T., Omuro, A.M., Raj, N., Razavi, P., Shoushtari, A.N., Shukla, N., Soumerai, T.E., Varghese, A.M., Yaeger, R., Coleman, J., Bochner, B., Riely, G.J., Saltz, L.B., Scher, H.I., Sabbatini, P.J., Robson, M.E., Klimstra, D.S., Taylor, B.S., Baselga, J., Schultz, N., Hyman, D.M., Arcila, M.E., Solit, D.B., Ladanyi, M., Berger, M.F., Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients, Nature Medicine, 23, (6), 2017, p703-713Journal Article, 2017
  • Park, J.J., Hajj, C., Reyngold, M., Shi, W., Zhang, Z., Cuaron, J.J., Crane, C.H., O"Reilly, E.M., Lowery, M.A., Yu, K.H., Goodman, K.A., Wu, A.J., Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer, Acta Oncologica, 2017, p1-8Journal Article, 2017
  • Creasy, J.M., Goldman, D.A., Dudeja, V., Lowery, M.A., Cercek, A., Balachandran, V.P., Allen, P.J., DeMatteo, R.P., Kingham, T.P., D'Angelica, M.I., Jarnagin, W.R., Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes, Journal of the American College of Surgeons, 224, (5), 2017, p906-916Journal Article, 2017
  • Varghese, A. M., Lowery, M. A., Yu, K. H., O'Reilly, E. M., Current management and future directions in metastatic pancreatic adenocarcinoma, Cancer, 122, 2016, p3765 -- 3775Journal Article, 2016
  • Abou-Alfa, G. K., Andersen, J. B., Chapman, W., Choti, M., Forbes, S. J., Gores, G. J., Hong, T. S., Harding, J. J., Vander Heiden, M. G., Javle, M., Kelley, R. K., Kwong, L. N., Lowery, M., Merrell, A., Miyabe, K., Rhim, A., Saha, S., Sia, D., Tanasanvimon, S., Venook, A., Valle, J. W., Walesky, C., Whetstine, J., Willenbring, H., Zhu, A. X., Mayer, D., Stanger, B. Z., Advances in cholangiocarcinoma research: Report from the third cholangiocarcinoma foundation annual conference, Journal of Gastrointestinal Oncology, 7, 2016, p819 -- 827Journal Article, 2016
  • Lowery, M. A., You, D., Samoila, A., Peerschke, E., Viale, A., Patel, R., Selcuklu, D., Rusek, M., Cercek, A., Kemeny, N., Harding, J., Mellinghoff, I., Tap, W., Abou-Alfa, G. K., Moynahan, M., Detection of IDH1 mutations in circulating free DNA in patients with cholangiocarcinoma, European Journal of Cancer, 69, 2016, pS141 -- S142Journal Article, 2016
  • Hicks, A. M., Chou, J., Capanu, M., Lowery, M. A., Yu, K. H., O'Reilly, E. M., Pancreas adenocarcinoma: Ascites, clinical manifestations, and management implications, Clinical Colorectal Cancer, 15, 2016, p360 -- 368Journal Article, 2016
  • Jordan, E., Braghiroli, M. I. F., Lowery, M. A., The role of novel biologics in biliary cancers, Minerva Gastroenterologica e Dietologica, 62, 2016, p325 -- 339Journal Article, 2016
  • Jordan, E. J., Basturk, O., Leach, S. D., Klimstra, D. S., Allen, P. J., Berger, M. F., Askan, G., Iacobuzio-Donahue, C. A., Yu, K. H., O'Reilly, E. M., Lowery, M. A., Clinical and molecular analysis of adenosquamous carcinoma of the pancreas, Journal of the Pancreas, 17, 2016, p620 -- 628Journal Article, 2016
  • , Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency., Chinese clinical oncology, 2016Journal Article, 2016
  • Smith, J. D., Lowery, M. A., Fell, D., Gallagher, D. J., Nash, G. M., Kemeny, N. E., Young patients with synchronous colorectal liver metastases, Journal of Surgical Oncology, 113, 2016, p473 -- 476Journal Article, 2016
  • Javle, M. M., Shroff, R. T., Zhu, A., Sadeghi, S., Choo, S., Borad, M. J., Lowery, M. A., El-Khoueiry, A., Macarulla, T., Philip, P. A., Oh, D. Y., Van Cutsem, E., Yeh, K. H., Isaacs, R., McGarry, C., Sen, S., Bekaii-Saab, T. S., A phase 2 study of BGJ398 in patients (pts) with advanced or metastatic FGFR-altered cholangiocarcinoma (CCA) who failed or are intolerant to platinum-based chemotherapy, Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Jordan, E., Basturk, O., Leach, S. D., Klimstra, D. S., Allen, P. J., Berger, M. F., Askan, G., Yu, K. H., O'Reilly, E. M., Lowery, M. A., Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP), Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Ben-Aharon, I., Elkabets, M., Pelossof, R., Yu, K. H., Allen, P. J., Iacobuzio-Donahue, C. A., Leach, S. D., Lowery, M. A., Goodman, K. A., O'Reilly, E. M., Genomic landscape of pancreatic adenocarcinoma: Does age matter?, Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Golan, T., Raitses-Gurevich, M., Kelley, R. K., Bocobo, A. G., Borgida, A., Shroff, R. T., Holter, S., Gallinger, S., Lowery, M. A., Abou-Alfa, G. K., Ahn, D. H., Jain, A., Bekaii-Saab, T. S., Friedman, E., Javle, M. M., Overall survival and clinical characteristics of BRCA germline/somatic cholangiocarcinoma (CCA), Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Hicks, A. M., O'Reilly, E. M., Capanu, M., Lowery, M. A., Yu, K. H., Presentation, clinical behavior, outcomes and therapies for patients with advanced pancreas adenocarcinoma (PAC) who present with or develop ascites, Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Lowery, M. A., Goff, L. W., Jordan, E., Wang, R., Bocobo, A. G., Chou, J. F., O'Reilly, E. M., Harding, J. J., Kemeny, N. E., Capanu, M., Griffin, A., McGuire, J. P., Venook, A. P., Abou-Alfa, G. K., Kelley, R. K., Second-line chemotherapy (CTx) outcomes in advanced biliary cancers (ABC): A retrospective multicenter analysis, Journal of Clinical Oncology, 34, 2016Journal Article, 2016
  • Silva, V.W.K., Askan, G., Daniel, T.D., Lowery, M., Klimstra, D.S., Abou-Alfa, G.K., Shia, J., Biliary carcinomas: Pathology and the role of DNA mismatch repair deficiency, Chinese Clinical Oncology, 5, (5), 2016Journal Article, 2016
  • Sahin, I. H., Lowery, M. A., Stadler, Z. K., Salo-Mullen, E., Iacobuzio-Donahue, C. A., Kelsen, D. P., O'Reilly, E. M., Genomic instability in pancreatic adenocarcinoma: A new step towards precision medicine and novel therapeutic approaches, Expert Review of Gastroenterology and Hepatology, 10, 2016, p893 -- 905Journal Article, 2016
  • Sahin, I.H., Lowery, M.A., Stadler, Z.K., Salo-Mullen, E., Iacobuzio-Donahue, C.A., Kelsen, D.P., O"Reilly, E.M., Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches, Expert Review of Gastroenterology and Hepatology, 10, (8), 2016, p893-905Journal Article, 2016
  • Harding JJ, Abu-Zeinah G, Chou JF, Owen DH, Ly M, Lowery MA, Capanu M, Do R, Kemeny NE, O'Reilly EM, Saltz LB, Abou-Alfa GK, Frequency, Morbidity, and Mortality of Bone Metastases in Advanced Hepatocellular Carcinoma., Journal of the National Comprehensive Cancer Network : JNCCN, 2018Journal Article, 2018
  • Lowery MA, Kelsen DP, Capanu M, Smith SC, Lee JW, Stadler ZK, Moore MJ, Kindler HL, Golan T, Segal A, Maynard H, Hollywood E, Moynahan M, O'Reilly EM, Phase II trial of veliparib in patients with previously treated BRCA-mutated pancreas ductal adenocarcinoma., European journal of cancer (Oxford, England : 1990), 2018Journal Article, 2018
  • Hicks AM, DeRosa A, Raj M, Do R, Yu KH, Lowery MA, Varghese A, O'Reilly EM, Visceral Thromboses in Pancreas Adenocarcinoma: Systematic Review., Clinical colorectal cancer, 2017Journal Article, 2017
  • Javle M, Lowery M, Shroff RT, Weiss KH, Springfeld C, Borad MJ, Ramanathan RK, Goyal L, Sadeghi S, Macarulla T, El-Khoueiry A, Kelley RK, Borbath I, Bekaii-Saab T, Phase II Study of BGJ398 in Patients With FGFR-Altered Advanced Cholangiocarcinoma., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017Journal Article, 2017
  • Jordan EJ, Basturk O, Shia J, Klimstra DS, Alago W, D'Angelica MI, Abou-Alfa GK, O'Reilly EM, Lowery MA, Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy., Journal of gastrointestinal oncology, 2017Journal Article, 2017
  • Chakraborty J, Langdon-Embry L, Cunanan KM, Escalon JG, Allen PJ, Lowery MA, O'Reilly EM, Gönen M, Do RG, Simpson AL, Preliminary study of tumor heterogeneity in imaging predicts two year survival in pancreatic cancer patients., PloS one, 2017Journal Article, 2017
  • Chakraborty, J., Langdon-Embry, L., Escalon, J. G., Allen, P. J., Lowery, M. A., O'Reilly, E. M., Do, R. K. G., Simpson, A. L., Styner, M. A., Angelini, E. D., Texture analysis for survival prediction of pancreatic ductal adenocarcinoma patients with neoadjuvant chemotherapy, Proceedings of SPIE, 9784, 2016, p9784 1W -- 9784 1WJournal Article, 2016
  • Salo-Mullen, E. E., O'Reilly, E. M., Kelsen, D. P., Ashraf, A. M., Lowery, M. A., Yu, K. H., Reidy, D. L., Epstein, A. S., Lincoln, A., Saldia, A., Jacobs, L. M., Rau-Murthy, R., Zhang, L., Kurtz, R. C., Saltz, L., Offit, K., Robson, M. E., Stadler, Z. K., Identification of germline genetic mutations in patients with pancreatic cancer, Cancer, 121, 2015, p4382 -- 4388Journal Article, 2015
  • Li, D., Capanu, M., Yu, K. H., Lowery, M. A., Kelsen, D. P., O'Reilly, E. M., Treatment, outcomes, and clinical trial participation in elderly patients with metastatic pancreas adenocarcinoma, Clinical Colorectal Cancer, 14, 2015, p269 -- 276Journal Article, 2015
  • Sadot, E., Doussot, A., O'Reilly, E. M., Lowery, M. A., Goodman, K. A., Do, R. K. G., Tang, L. H., Gönen, M., D'Angelica, M. I., DeMatteo, R. P., Kingham, T. P., Jarnagin, W. R., Allen, P. J., FOLFIRINOX induction therapy for stage 3 pancreatic adenocarcinoma, Annals of Surgical Oncology, 22, 2015, p3512 -- 3521Journal Article, 2015
  • Thorek, D. L. J., Kramer, R. M., Chen, Q., Jeong, J., Lupu, M. E., Lee, A. M., Moynahan, M. E., Lowery, M., Ulmert, D., Zanzonico, P., Deasy, J. O., Humm, J. L., Russell, J., Reverse-contrast imaging and targeted radiation therapy of advanced pancreatic cancer models, International Journal of Radiation Oncology, Biology, Physics, 93, 2015, p444 -- 453Journal Article, 2015
  • Picozzi, V. J., Ramanathan, R. K., Lowery, M. A., Ocean, A. J., Mitchel, E. P., O'Neil, B. H., Guarino, M. J., Conkling, P. R., Cohen, S. J., Bahary, N., Frank, R. C., Dragovich, T., Bridges, B. B., Braiteh, F. S., Starodub, A. N., Lee, F. C., Gribbin, T. E., Richards, D. A., Lee, M., Korn, R. L., Pandit-Taskar, N., Goldsmith, S. J., Intenzo, C. M., Sheikh, A., Manzone, T. C., Horne, H., Sharkey, R. M., Wegener, W. A., O'Reilly, E. M., Goldenberg, D. M., Von Hoff, D. D., 90Y-clivatuzumab tetraxetan with or without low-dose gemcitabine: A phase Ib study in patients with metastatic pancreatic cancer after two or more prior therapies, European Journal of Cancer, 51, 2015, p1857 -- 1864Journal Article, 2015
  • Lowery, M. A., O'Reilly, E. M., Novel therapeutics for pancreatic adenocarcinoma, Hematology/Oncology Clinics of North America, 29, 2015, p777 -- 787Journal Article, 2015
  • Picozzi, V. J., Ramanathan, R. K., Lowery, M. A., Ocean, A. J., Mitchell, E. P., O'Neil, B. H., Guarino, M. J., Conkling, P. R., Cohen, S. J., Bahary, N., Frank, R. C., Dragovich, T., Bridges, B. B., Lee, M., Korn, R. L., Pandit-Taskar, N., Goldsmith, S. J., Intenzo, C. M., Sheikh, A., Manzone, T. C., Miller, M. L., Yu, M., Joyce, J. M., Strauss, E. B., Passalaqua, S., Dorn, R. V., Anderson, M. J., Holt, M., Braiteh, F. S., Lee, F. C., Gribbin, T. E., Richards, D. A., Starodub, A. N., William, W. A., O'Reilly, E. M., Von Hoff, D. D., Goldenberg, D. M., Final results of a randomized phase 1b study of fractionated 90Y-clivatuzumab tetraxetan in patients with metastatic pancreatic cancer having at least two prior therapies, Cancer Research, 75, 2015Journal Article, 2015
  • Lowery, M. A., O'Reilly, E. M., Harding, J. J., Salehi, E., Hollywood, E., Bradley, M., Sophos, N. A., Ly, M., Capanu, M., Gerst, S. R., Saltz, L., Abou-Alfa, G. K., A phase I trial of binimetinib in combination with gemcitabine (G) and cisplatin (C) patients (pts) with untreated advanced biliary cancer (ABC), Journal of Clinical Oncology, 33, 2015Journal Article, 2015
  • Harding, J. J., Abu Zeinah, G., Chou, J. F., Owen, D. H., Ly, M., Lowery, M. A., O'Reilly, E. M., Capanu, M., Saltz, L., Abou-Alfa, G. K., Hepatocellular carcinoma (HCC) and bone metastases (Mets), Journal of Clinical Oncology, 33, 2015Journal Article, 2015
  • Connell, L. C., Harding, J. J., Lowery, M. A., Kemeny, N. E., Cercek, A., Abdelgawad, M. I., O'Reilly, E. M., Saltz, L., Abou-Alfa, G. K., Platinum-based combination therapy (PCT) and outcomes for patients (pts) with mixed hepatocellular carcinoma and intrahepatic cholangiocarcinoma (mHCC/ICC), Journal of Clinical Oncology, 33, 2015Journal Article, 2015
  • Lowery MA, Ptashkin RN, Jordan EJ, Berger MF, Zehir A, Capanu M, Kemeny NE, O'Reilly EM, El Dika I, Jarnagin WR, Harding JJ, D'Angelica MI, Cercek A, Abou-Alfa GK, Comprehensive molecular profiling of intra- and extrahepatic cholangiocarcinomas: potential targets for intervention., Clinical cancer research : an official journal of the American Association for Cancer Research, 2018Journal Article, 2018
  • Lowery MA, Wong W, Jordan EJ, Lee JW, Kemel Y, Vijai J, Mandelker D, Zehir A, Capanu M, Salo-Mullen E, Arnold AG, Yu KH, Varghese AM, Kelsen DP, O'Reilly EM, Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms., Journal of the National Cancer Institute, 2018Journal Article, 2018
  • James J. Harding, Maeve Aine Lowery, Khrystyna Uhlitskykh, Peter Justin Wan, Casey R Hamilton, Adalberto Barba, Kay Chia-Wei Liu, Amanda Johnston, John S. Bomalaski, Eileen Mary O'Reilly, Leonard Saltz, Ghassan K. Abou-Alfa, A phase I study of mFOLFOX6 and ADI-PEG-20 in patients (pts) with advanced hepatocellular carcinoma (HCC) and other gastrointestinal (GI) malignancies., Journal of Clinical Oncology, 35, (4{\_), 2017, p384--384Journal Article, 2017
  • Maeve Aine Lowery, Eileen Mary O'Reilly, James J. Harding, Kenneth H. Yu, Andrea Cercek, Ellen Hollywood, Erica Salehi, Ezra Margona, Mikaela Bradley, Trevor Witter, Scott R. Gerst, Marinela Capanu, Leonard Saltz, Ghassan K. Abou-Alfa, A phase I/II trial of MEK162 in combination with gemcitabine (G) and cisplatin (C) for patients (pts) with untreated advanced biliary cancer (ABC)., Journal of Clinical Oncology, 35, (4{\_), 2017, p290--290Journal Article, 2017
  • Taryn Mary Boucher, Nancy E. Kemeny, Joanne F. Chou, Marinela Capanu, Maeve Aine Lowery, Andrea Cercek, Analysis of prior malignancies in patients with cholangiocarcinoma., Journal of Clinical Oncology, 35, (4{\_), 2017, p305--305Journal Article, 2017
  • Angel Mier Hicks, Micheal Raj, Richard Kinh Gian Do, Kenneth H. Yu, Maeve Aine Lowery, Anna M. Varghese, Eileen Mary O'Reilly, Clinical impact of visceral thrombosis (VT) in pancreatic ductal adenocarcinoma (PDAC)., Journal of Clinical Oncology, 35, (4{\_), 2017, p260--260Journal Article, 2017
  • Maeve Aine Lowery, James J. Harding, Kenneth H. Yu, David Paul Kelsen, John S. Bomalaski, Danielle C. Glassman, Christina M. Covington, Robin Brenner, Ellen Hollywood, Adalberto Barba, Amanda Johnston, Kay Chia-Wei Liu, Marinela Capanu, Ghassan K. Abou-Alfa, Eileen Mary O'Reilly, Phase IB trial of ADI-PEG 20 (A) plus nab-paclitaxel (nab-P) and gemcitabine (gem) in patients with advanced pancreatic cancer (PC)., Journal of Clinical Oncology, 35, (4{\_), 2017, p295--295Journal Article, 2017
  • Lowery MA, Genotype-phenotype correlation in BRCA1/2 mutation-associated pancreatic cancer., British journal of cancer, 2019Journal Article, 2019
  • Cercek A, Boerner T, Tan BR, Chou JF, Gönen M, Boucher TM, Hauser HF, Do RKG, Lowery MA, Harding JJ, Varghese AM, Reidy-Lagunes D, Saltz L, Jarnagin WR, Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial., JAMA oncology, 2019Journal Article, 2019
  • Lowery MA, Goff LW, Keenan BP, Jordan E, Wang R, Bocobo AG, Chou JF, O'Reilly EM, Harding JJ, Kemeny N, Capanu M, Griffin AC, McGuire J, Venook AP, Kelley RK, Second-line chemotherapy in advanced biliary cancers: A retrospective, multicenter analysis of outcomes., Cancer, 2019Journal Article, 2019
  • Noel M, O'Reilly EM, Wolpin BM, Ryan DP, Bullock AJ, Britten CD, Linehan DC, Belt BA, Gamelin EC, Ganguly B, Yin D, Joh T, Jacobs IA, Taylor CT, Lowery MA, Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma., Investigational new drugs, 2019Journal Article, 2019
  • Lowery MA, Burris HA, Janku F, Shroff RT, Cleary JM, Azad NS, Goyal L, Maher EA, Gore L, Hollebecque A, Beeram M, Trent JC, Jiang L, Fan B, Abou-Alfa GK, Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study., The lancet. Gastroenterology & hepatology, 2019Journal Article, 2019
  • Fan B, Mellinghoff IK, Wen PY, Lowery MA, Goyal L, Tap WD, Pandya SS, Manyak E, Jiang L, Liu G, Nimkar T, Gliser C, Prahl Judge M, Agresta S, Yang H, Dai D, Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors., Investigational new drugs, 2019Journal Article, 2019
  • Wong W, Lowery MA, Berger MF, Kemel Y, Taylor B, Zehir A, Srinivasan P, Bandlamudi C, Chou J, Capanu M, Varghese A, Yu KH, Iacobuzio-Donahue CA, O'Reilly EM, Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes., Cancer, 2019Journal Article, 2019
  • Ben-Aharon I, Elkabets M, Pelossof R, Yu KH, Iacubuzio-Donahue CA, Leach SD, Lowery MA, Goodman KA, O'Reilly EM, Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?, Clinical cancer research : an official journal of the American Association for Cancer Research, 2019Journal Article, 2019
  • Lowery, M.A., Bradley, M., Chou, J.F., Capanu, M., Gerst, S., Harding, J.J., Dika, I.E., Berger, M., Zehir, A., Ptashkin, R., Wong, P., Rasalan-Ho, T., Yu, K.H., Cercek, A., Morgono, E., Salehi, E., Valentino, E., Hollywood, E., O'Reilly, E.M., Abou-Alfa, G.K., Binimetinib plus gemcitabine and cisplatin phase I/II trial in patients with advanced biliary cancers, Clinical Cancer Research, 25, (3), 2019, p937-945Journal Article, 2019
  • Donlon NE, Ravi N, King S, Cunninhgam M, Cuffe S, Lowery M, Wall C, Hughes N, Muldoon C, Ryan C, Moore J, O'Farrell C, Gorry C, Duff AM, Enright C, Reynolds JV, Modern oncological and operative outcomes in oesophageal cancer: the St. James's hospital experience., Irish journal of medical science, 2020Journal Article, 2020
  • Power R, Lowery MA, Reynolds JV, Dunne MR, The Cancer-Immune Set Point in Oesophageal Cancer., Frontiers in oncology, 2020Journal Article, 2020
  • Abou-Alfa GK, Macarulla T, Javle MM, Kelley RK, Lubner SJ, Adeva J, Cleary JM, Catenacci DV, Borad MJ, Bridgewater J, Harris WP, Murphy AG, Oh DY, Zhu AX, Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study., The Lancet. Oncology, 2020Journal Article, 2020
  • Maynard H, Stadler ZK, Berger MF, Solit DB, Ly M, Lowery MA, Mandelker D, Zhang L, Jordan E, El Dika I, Kemel Y, Ladanyi M, Robson ME, O'Reilly EM, Abou-Alfa GK, Germline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings., Cancer, 2020Journal Article, 2020
  • O'Reilly EM, Lee JW, Zalupski M, Capanu M, Park J, Golan T, Tahover E, Lowery MA, Chou JF, Sahai V, Brenner R, Kindler HL, Yu KH, Zervoudakis A, Kelsen DP, Randomized, Multicenter, Phase II Trial of Gemcitabine and Cisplatin With or Without Veliparib in Patients With Pancreas Adenocarcinoma and a Germline BRCA/PALB2 Mutation., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020Journal Article, 2020
  • Seoighe C, Bracken AP, Buckley P, Doran P, Green R, Healy S, Kavanagh D, Kenny E, Lawler M, Lowery M, Morris D, Morrissey D, O'Byrne JJ, Shields D, Kolch W, The future of genomics in Ireland " focus on genomics for health, 2020Journal Article, 2020
  • Power R, Leavy C, Nolan C, White N, Clarke R, Cadoo KA, Gallagher DJ, Lowery MA, Prevalence of pancreaticobiliary cancers in Irish families with pathogenic BRCA1 and BRCA2 variants., Familial cancer, 2020Journal Article, 2020
  • Lowery, M.A., Burris, H.A., Janku, F., Shroff, R.T., Cleary, J.M., Azad, N.S., Goyal, L., Maher, E.A., Gore, L., Hollebecque, A., Beeram, M., Trent, J.C., Jiang, L., Fan, B., Aguado-Fraile, E., Choe, S., Wu, B., Gliser, C., Agresta, S.V., Pandya, S.S., Zhu, A.X., Abou-Alfa, G.K., Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study, The Lancet Gastroenterology and Hepatology, 4, (9), 2019, p711-720Journal Article, 2019
  • Lowery MA, Bradley M, Chou JF, Capanu M, Gerst S, Harding JJ, Dika IE, Berger M, Zehir A, Ptashkin R, Wong P, Rasalan-Ho T, Yu KH, Cercek A, Abou-Alfa GK, Binimetinib plus Gemcitabine and Cisplatin Phase I/II Trial in Patients with Advanced Biliary Cancers., Clinical cancer research : an official journal of the American Association for Cancer Research, 2018Journal Article, 2018
  • Yu KH, Ricigliano M, McCarthy B, Chou JF, Capanu M, Cooper B, Bartlett A, Covington C, Lowery MA, O'Reilly EM, Circulating Tumor and Invasive Cell Gene Expression Profile Predicts Treatment Response and Survival in Pancreatic Adenocarcinoma., Cancers, 2018Journal Article, 2018
  • Jordan, E.J., Lowery, M.A., Basturk, O., Allen, P.J., Yu, K.H., Tabar, V., Beal, K., Reidy, D.L., Yamada, Y., Janjigian, Y., Abou-Alfa, G.K., O'Reilly, E.M., Brain Metastases in Pancreatic Ductal Adenocarcinoma: Assessment of Molecular Genotype"Phenotype Features"An Entity With an Increasing Incidence?, Clinical Colorectal Cancer, 17, (2), 2018, pe315-e321Journal Article, 2018
  • Hu, Z.I., Shia, J., Stadler, Z.K., Varghese, A.M., Capanu, M., Salo-Mullen, E., Lowery, M.A., Diaz, L.A., Mandelker, D., Yu, K.H., Zervoudakis, A., Kelsen, D.P., Iacobuzio-Donahue, C.A., Klimstra, D.S., Saltz, L.B., Sahin, I.H., O'Reilly, E.M., Evaluating mismatch repair deficiency in pancreatic adenocarcinoma: Challenges and recommendations, Clinical Cancer Research, 24, (6), 2018, p1326-1336Journal Article, 2018
  • Mier-Hicks, A., Raj, M., Do, R.K., Yu, K.H., Lowery, M.A., Varghese, A., O'Reilly, E.M., Incidence, Management, and Implications of Visceral Thrombosis in Pancreatic Ductal Adenocarcinoma, Clinical Colorectal Cancer, 17, (2), 2018, p121-128Journal Article, 2018
  • Harding, J.J., Lowery, M.A., Shih, A.H., Schvartzman, J.M., Hou, S., Famulare, C., Patel, M., Roshal, M., Do, R.K., Zehir, A., You, D., Selcuklu, S.D., Viale, A., Tallman, M.S., Hyman, D.M., Reznik, E., Finley, L.W.S., Papaemmanuil, E., Tosolini, A., Frattini, M.G., Macbeth, K.J., Liu, G., Fan, B., Choe, S., Wu, B., Janjigian, Y.Y., Mellinghoff, I.K., Diaz, L.A., Levine, R.L., Abou-Alfa, G.K., Stein, E.M., Intlekofer, A.M., Isoform switching as a mechanism of acquired resistance to mutant isocitrate dehydrogenase inhibition, Cancer Discovery, 8, (12), 2018, p1540-1546Journal Article, 2018
  • O'Reilly, E.M., Lee, J.W., Lowery, M.A., Capanu, M., Stadler, Z.K., Moore, M.J., Dhani, N., Kindler, H.L., Estrella, H., Maynard, H., Golan, T., Segal, A., Salo-Mullen, E.E., Yu, K.H., Epstein, A.S., Segal, M., Brenner, R., Do, R.K., Chen, A.P., Tang, L.H., Kelsen, D.P., Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline BRCA mutation carriers and wild-type BRCA pancreatic ductal adenocarcinoma, Cancer, 124, (7), 2018, p1374-1382Journal Article, 2018
  • Harding JJ, Lowery MA, Shih AH, Schvartzman JM, Hou S, Famulare C, Patel M, Roshal M, Do RKG, Zehir A, You D, Selcuklu SD, Viale A, Tallman MS, Intlekofer AM, Isoform switching as a mechanism of acquired resistance to isocitrate dehydrogenase inhibition, 2018Journal Article, 2018
  • Varghese AM, Singh I, Singh R, Kunte S, Chou JF, Capanu M, Wong W, Lowery MA, Stadler ZK, Salo-Mullen E, Saadat LV, Wei AC, Reyngold M, Basturk O, O'Reilly EM, Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes., Journal of the National Cancer Institute, 2021Journal Article, 2021
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