| Title |
Authors |
Publication |
Spec |
| Psychiatric genetics: what's new in 2015? |
Corvin A, O'Donovan |
MC Lancet Psychiatry, 2016 |
A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders. |
| Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. |
Schizophrenia Working Group of the Psychiatric Genomics Consortium |
Nature, 2014 |
In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings. |
| De novo mutations in schizophrenia implicate chromatin remodelling and support genetic overlap with ASD and ID |
McCarthy et al. |
Molecular Psychiatry, 2014 |
In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1. |
| An inherited duplication at the gene P21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis |
Morris DW et al. |
Human Molecular Genetics, 2014 |
We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations. |
| Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders |
Kenny EM, et al. |
Molecular Psychiatry, 2014 |
In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data. |
| Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia |
Irish Schizophrenia Genomics Consortium & WTCCC2 |
Biological Psychiatry, 2012 |
In a GWAS study of our cohort we provided further evidence for the role of MHC class I molecules in schizophrenia etiology. |
| Molecular pathways involved in neuronal cell adhesion and membrane scoffolding contribute to schizophrenia and bipolar disorder susceptibility |
O'Dushlaine C, et al. |
Molecular Psychiatry, 2011 |
|
| Common polygenic variation contributes to risk in schizophrenia and bipolar disorder |
O'Dushlaine C, et al. |
Nature, 2009 |
|
| Rare chromosomal deletions and duplications increase risk of schizophrenia |
International Schizophrenia Consortium |
Nature, 2008 |
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