Research Projects
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The academic staff members in Physiology run active research programmes, with laboratories based in the Trinity Biomedical Sciences Institute, the Trinity College Institute of Neuroscience, Lloyd Building, and the Watts Building. Some of the research projects ongoing are listed below. Feel free to contact us for further information.
| Research Group | Disease | Mechanisms | Therapies |
|---|---|---|---|
| Kumlesh Dev Drug Development Research Group |
Krabbes Disease & novel therapies | Demyelination & Neuroinflammation | Astrocytes as drug targets |
| Alzheimer's Disease & drug development | S1P Receptors as drug targets | Drug Development: Discovery to market | |
| Eric Downer Translational Neuroimmunology Research Group |
Multiple Sclerosis & drug development | Neuropathic orofacial pain | Cannabinoid Therapeutics |
| Multiple Sclerosis & exercise | Innovative teaching strategies | Cannabinoid pharmacology | |
| Mikel Egana Human Exercise Physiology Research Group |
Cardiovascular Health | Exercise tolerance and ageing | Recovery exercise performance |
| Type 2 diabetes & exercise tolerance | Oxygen uptake response to exercise | Circulation and muscle fatigue | |
| Aine Kelly Kelly Lab |
Alzheimer's Disease & Exercise | BDNF & TrkB neuronal signaling | Preventing age-related cognitive decline |
| Exercise, cognition & neuroprotection | Biomarkers of concussion in sport | Exercise as an anti-inflammatory | |
| Veronica Campbell Lab |
Alzheimer's disease | Neurodegenerative pathways | Cannabinoid Pharmacology |
| Osteoarthritis | Tissue engineering & adult stem cell biology | Cannabinoid Pharmacology; Novel Scaffolds | |
| Maeve Caldwell Stem Cell Biology Research Group |
Parkinson's disease and neuroprotection | Animal & neuronal/glial human cell models | MANF and CDNF |
| Alzheimer's disease | Astrocytes: role in neuronal cell death | APOE genotypes | |
| Deirdre Edge Edge Lab |
Central pathology in mdx mice | Exploring the respiratory network | Beyond muscle targets |
| mdx respiratory muscle remodeling | Fibre type distribution and inflammation | Anti-inflammatory approaches | |
| Alice Witney Sensorimotor Neuromodulation Lab |
Motor learning in health and disease | Modifying neuronal excitability using TMS, tACS, tDCS | Non-invasive neurostimulation protocols |
| Quantitative Sensory Testing for Pain | Optogenetics in the teaching laboratory | Posture and balance interventions | |
| Marina Lynch Neuroinflammation Research Group |
Alzheimer's Disease | Neuroinflammation Infiltrating cells | Modulatio of the Inflammasome & BBB |
| Age-related neurodegeneration | Microglial activation | Anti-inflammatory strategies |