Dr. Stephen Maher

• Lynam-Lennon N, Maher SG, Reynolds JV, The roles of microRNA in cancer and apoptosis., Biological reviews of the Cambridge Philosophical Society, 84, (1), 2009, p55-71Journal Article, 2009
• Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397Journal Article, 2016, DOI
• Mongan A.M, Lynam-Lennon N, Casey R, Maher S, Pidgeon G, Reynolds J.V, O†Sullivan J, Erratum to: Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma (Clin Transl Oncol, 10.1007/s12094-015-1411-y), Clinical and Translational Oncology, 18, (6), 2016, p651-Journal Article, 2016, DOI , URL
• Bibby B.A.S, Reynolds J.V, Maher S.G, MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma, PLoS ONE, 10, (7), 2015, p013418-Journal Article, 2015, DOI , URL , TARA - Full Text
• Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Reynolds JV, O'Sullivan J, Dysfunctional mitochondria and enhanced metabolic plasticity is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE, 9, 2014, pe100738Journal Article, 2014
• MicroRNA and cancer in, editor(s)Steven G Gray , Epigenetic cancer therapy, London, Elsevier, 2015, pp67 - 90, [Maher SG, Bibby B, Moody H, Reid G]Book Chapter, 2015
• Mongan AM, Lynam-Lennon N, Casey R, Maher SG, Pidgeon GP, Reynolds JV, O'Sullivan J, Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma, Clinical Translational Oncology, 18, 2016, p632 - 640Journal Article, 2016
• Moore C, Wood T, Cawthorne C, Hilton K, Maher SG, Saunderson J, Archibald SJ, Beavis AW, A method to calibrate the RS2000 X-ray biological irradiator for radiobiological flank irradiation of mice, Biomedical Physics and Engineering Express, 2, 2016, p037001Journal Article, 2016
• Lynam-Lennon N, Heavey S, Sommerville G, Bibby BA, Ffrench B, Quinn J, Gasch C, O'Leary JJ, Gallagher MF, Reynolds JV, Maher SG, MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8, (7), 2017, p11400 - 11413Journal Article, 2017, DOI , TARA - Full Text
• Heavey S, Dowling P, Moore G, Barr MP, Kelly N, Maher SG, Cuffe S, Finn SP, O'Byrne KJ, Gately K., Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines., Scientific Reports, 8, (1), 2018, p1652-Journal Article, 2018, DOI , TARA - Full Text
• Conroy MJ, Maher SG, Melo AM, Doyle SL, Foley E, Reynolds JV, Long A, Lysaght J., Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8+ T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients., Frontiers in immunology, 9, 2018, p1867Journal Article, 2018, DOI , TARA - Full Text
• Moody HL, Lind MJ, Maher SG., MicroRNA-31 Regulates Chemosensitivity in Malignant Pleural Mesothelioma., Molecular therapy. Nucleic acids, 8, 2017, p317-329Journal Article, 2017, DOI
• Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129Journal Article, 2019, DOI
• Amy Buckley, Becky Bibby, Margaret Dunne, Susan Kennedy, Maria Davern, Breandan Kennedy, Stephen Maher, Jacintha O'Sullivan, Characterisation of an isogenic model of cisplatin resistance in oesophageal adenocarcinoma cells, Pharmaceuticals, 2019Journal Article, 2019
• CMcCrory, Clinical pain perception, Faculty of Pain Medicine, 2013Invited Talk, 2013
• Bibby BA, Miranda CS, Reynolds JV, Cawthorne CJ, Maher SG, Silencing microRNA-330-5p increases MMP1 expression and promotes an invasive phenotype in oesophageal adenocarcinoma, BMC Cancer, 19, 2019, p784-Journal Article, 2019
• Melo AM, Maher SG, O'Leary SM, Doherty DG, Lysaght J, Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro, Radiotherapy and Oncology, 145, 2020, p128 - 136Journal Article, 2020, DOI , TARA - Full Text
• Moody HL, Lind MJ, Maher SG, MicroRNA-31 expression mediates chen-resistance in malignant pleural mesothelioma, Lung Cancer, 87, 2015, ppS1 - S2Poster, 2015
• Moody HL, Lind MJ, Maher SG, MicroRNA-31 regulates chemrsensitivity in malignant pleural mesothelioma via altered intracellular drug localisation, European Journal of Cancer, 61, 2016, ppS140-Poster, 2016
• Argyle SD, Bibby BAS, Lynam-Lennon N, Reynolds JV, Cawthorne C, Maher SG, Investigating the role of miR-187 as a modulator of chen-radiation sensitivity in oesophageal adenocarcinoma, European Journal on Cancer, 61, 2016, ppS158 - S159Poster, 2016
• Bibby BAS, Cawthorne C, Reynolds JV, Maher SG, MicroRNA-330-5p downregulation in oesophageal adenocarcinoma is a potential therapeutic target for enhancing chemoradiation sensitivity in patients, European Journal on Cancer, 61, 2016, ppS158-Poster, 2016
• Buckley A, Lynam-Lennon N, Kennedy S, Cannon A, O'Toole D, Maher SG, Reynolds JV, Ravi N, Kennedy B, O'Sullivan J, The action of a novel radio sensitiser within the oesophageal adenocarcinoma tumour microenvironment, Diseases of the Esophagus, 31, 2018, pp171-Poster, 2018
• Heavey S, Lynam-Lennon N, Quinn J, Sommerville G, Simpson BS, Reynolds JV, Maher SG, miR-153 and two members of the miR-17/92 cluster are upregulated in a stem-like subpopulation of radioresistant esopahgeal cancer cells, targeting genes involved in EMT, radioresistance and stemness, Journal of Molecular Medicine, 2020Journal Article, 2020
• Edge SD, Renard I, Pyne E, Li C, Moody H, Roy R, Beavis AW, Archibald SJ, Cawthorne CJ, Maher SG, Pires IM., PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma., The British journal of radiology, 94, (1119), 2021, p20201191Journal Article, 2021, DOI
• Kane LE, Mellotte GS, Conlon KC, Ryan BM, Maher SG., Multi-Omic Biomarkers as Potential Tools for the Characterisation of Pancreatic Cystic Lesions and Cancer: Innovative Patient Data Integration., Cancers, 13, (4), 2021Journal Article, 2021, DOI
• Davern M, Donlon NE, Sheppard A, Connell FO, Hayes C, Bhardwaj A, Foley E, Toole DO, Lynam-Lennon N, Ravi N, Reynolds JV, Maher SG, Lysaght J., Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells., Translational oncology, 14, (6), 2021, p101062Journal Article, 2021, DOI
• Alhusaini A, Cannon A, Maher SG, Reynolds JV, Lynam-Lennon N., Therapeutic Potential of PARP Inhibitors in the Treatment of Gastrointestinal Cancers., Biomedicines, 9, (8), 2021Journal Article, 2021, DOI
• Mylod E, McKenna E, Davern M, Barr MP, Donlon NE, Bibby BA, Bhardwaj A, Reynolds JV, Lysaght J, Maher SG, Conroy MJ., Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses, Clinical and Experimental Medicine, 2022Journal Article, 2022
• Davern M, Fitzgerald MC, Buckley CE, Heeran AB, Donlon NE, McGrath J, O'Connell F, Deshpande MR, Hayes C, MacDonald J, Sheppard AD, Reynolds JV, Maher SG, Lynam-Lennon N, Murphy B, Lysaght J, PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours, Cancer Letters, 2022Journal Article, 2022
• Kane LE, Mellotte GS, Mylod E, O'Brien RM, O'Connell F, Buckley CE, Arlow J, Nguyen K, Mockler D, Meade AD, Ryan BM, Maher SG, Diagnostic accuracy of blood-based biomarkers for pancreatic cancer: A systematic review and meta-analysis, Gastroenterology, 2022Journal Article, 2022
• McGrath J, Kane LE, Lowery ME, Maher SG, The influence of microRNA-31 on oxidative stress and radiosensitivity in pancreatic ductal adenocarcinoma, International Journal of Molecular Sciences, 2022Journal Article, 2022
• Kane LE, Ryan BM, Maher SG, Multi-omic profiling of pancreatic cyst fluid for the identification of a novel biomarker panel of patient cancer risk, Irish Society of Gastroenterology Winter Meeting, 2021Oral Presentation, 2021
• Kane LE, Ryan BM, Maher SG, Diagnostic accuracy of blood-based biomarkers for pancreatic cancer, 2021, 2021Oral Presentation, 2021
• Kane LE, Ryan BM, Maher SG, Diagnostic accuracy of blood-based biomarkers for pancreatic cancer: A systematic review and meta-analysis, AACR Pancreatic Cancer Special Conference, 2021, 2021Oral Presentation, 2021
• Kane LE, Ryan BM, Maher SG, Multi-omic profiling of pancreatic cyst fluid for the identification of a novel biomarker panel of patient cancer risk, AACR Pancreatic Cancer Special Conference, 2021, 2021Oral Presentation, 2021
• Kane LE, Ryan BM, Maher SG, Investigating the role of pancreatic cyst fluid in the development of pancreatic cancer, IACR Annual Meeting, 2021, 2021Oral Presentation, 2021
• Kane LE, Ryan BM, Maher SG, Investigating the role of pancreatic cyst fluid in the development of pancreatic cancer, IACR Annual Meeting, 2021, 2021Oral Presentation, 2021
• Kane LE, Lyons R, Mellotte G, Ryan BM, Maher SG, Profiling the immune component of pancreatic cyst fluid to identify novel biomarkers of patient cancer risk, British Society of Immunology Congress, 2021, 2021Poster, 2021
• Kane LE, Ryan BM, Maher SG, Multi-omic profiling of pancreatic cyst fluid for the identification of a novel biomarker panel of patient cancer risk, Cancer Research, 2021, 81, (22), 2021, pp7 - 8Poster, 2021
• Davern, M. and O†Brien, R.M. and McGrath, J. and Donlon, N.E. and Melo, A.M. and Buckley, C.E. and Sheppard, A.D. and Reynolds, J.V. and Lynam-Lennon, N. and Maher, S.G. and Lysaght, J., PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma, Scientific Reports, 12, (1), 2022Journal Article, 2022, DOI , URL
• Davern, M. and Donlon, N.E. and O†Connell, F. and Sheppard, A.D. and Hayes, C. and King, R. and Temperley, H. and Butler, C. and Bhardwaj, A. and Moore, J. and Bracken-Clarke, D. and Donohoe, C. and Ravi, N. and Reynolds, J.V. and Maher, S.G. and Conroy, M.J. and Lysaght, J., Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma, Translational Oncology, 20, (101406), 2022Journal Article, 2022, DOI , URL
• Maher, S.G. and Sheikh, F. and Scarzello, A.J. and Romero-Weaver, A.L. and Baker, D.P. and Donnelly, R.P. and Gamero, A.M., IFNα and IFNλ differ in their antiproliferative effects and duration of JAK/STAT signaling activity, Cancer Biology and Therapy, 7, (7), 2008, p1109-1115Journal Article, 2008, DOI , URL
• Scarzello, A.J. and Romero-Weaver, A.L. and Maher, S.G. and Veenstra, T.D. and Zhou, M. and Qin, A. and Donnelly, R.P. and Sheikh, F. and Gamero, A.M., A mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis, Molecular Biology of the Cell, 18, (7), 2007, p2455-2462Journal Article, 2007, DOI , URL
• Donlon NE, Davern M, O'Connell F, Sheppard A, Heeran A, Bhardwaj A, Butler C, Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, Maher S, O'Sullivan J, Reynolds JV, Lysaght J., Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma, World Journal of Gastroenterology, 2022Journal Article, 2022
• Davern M, Donlon NE, Sheppard AS, Majcher KD, Connell FO, Heeran AB, Grant M, Farrell RA, Hayes C, Bracken-Clarke D, Conroy MJ, Foley E, Toole DO, Bhardwaj A, Ravi N, Reynolds JV, Maher SG, Sullivan JO, Lysaght J., FLOT and CROSS chemotherapy regimens alter the frequency of CD27+ and CD69+ T cells in oesophagogastric adenocarcinomas: implications for combination with immunotherapy, Journal of Cancer Research and Clinical Oncology, 2022Journal Article, 2022, URL
• McGrath, J. and Kane, L.E. and Maher, S.G., The Influence of MicroRNA-31 on Oxidative Stress and Radiosensitivity in Pancreatic Ductal Adenocarcinoma, Cells, 11, (15), 2022Journal Article, 2022, DOI , URL
• Interferon-gamma in, editor(s)Alexander Zdanov , Class II Cytokines, Kerala, India, Transworld Research Network, Research Signpost, 2008, pp51 - 106, [Howard A. Young, Ana L. Romero-Weaver, Ram Savan, Stephen G. Maher, Jonathan M. Weiss]Book Chapter, 2008
• Anthony J. Scarzello, Ana L. Romero-Weaver, Stephen G. Maher, Timothy D. Veenstra, Ming Zhou, Angel Qin, Raymond P. Donnelly, Faruk Sheikh, Ana M. Gamero, A Mutation in the SH2 Domain of STAT2 Prolongs Tyrosine Phosphorylation of STAT1 and Promotes Type-I IFN-induced Apoptosis, Molecular Biology of the Cell, 18, 2007, p2455 - 2462Journal Article, 2007
• Stephen G. Maher, Ana L. Romero-Weaver, Anthony J. Scarzello, Ana M. Gamero, Interferon: Cellular Executioner or White Knight?, Current Medicinal Chemistry, 14, 2007, p1279 - 1289Journal Article, 2007
• Stephen G. Maher, Claire M. Condron, David J. Bouchier-Hayes, Deirdre M. Toomey, Taurine attenuates CD3/Interleukin-2-induced T cell Apoptosis in an in vitro model of Activation-Induced Cell Death (AICD), Clinical and Experimental Immunology, 139, 2005, p279 - 286Journal Article, 2005
• Stephen G. Maher, Deirdre M. Toomey, Claire M. Condron, David J. Bouchier-Hayes, Activation-induced Cell Death: The Controversial Role of Fas and Fas Ligand in Immune Privilege and Tumour Counterattack, Immunology and Cell Biology, 80, 2002, p131 - 137Journal Article, 2002
• Stephen G. Maher, Faruk Sheikh, Anthony J. Scarzello, Ana L. Romero-Weaver, Darren P. Baker, Raymond P. Donnelly, Ana M. Gamero, IFN-alpha and IFN-lambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity, Cancer Biology and Therapy, 7, (7), 2008, p1109 - 1115Journal Article, 2008
• Niamh Lynam-Lennon, Stephen G. Maher, John V. Reynolds, The Roles of microRNA in Cancer and Apoptosis, Biological Reviews, 84, (1), 2009, p55 - 71Journal Article, 2009
• Catriona H. Miller, Stephen G. Maher, Howard A. Young, Cytokine therapies: clinical applications of interferon-gamma, Annals of the New York Academy of Sciences, 1182, 2009, p69 - 79Journal Article, 2009
• Miriam Byrne, John V. Reynolds, James S. O'Donnell, Mary Keogan, Barry White, Mary Byrne, Seamas Murphy, Stephen G. Maher, Graham P. Pidgeon, Activation of the procoagulant response following neoadjuvant chemotherapy and radiation therapy, and long-term activation following major cancer surgery., British Journal of Cancer, 102, (1), 2010, p73 - 79Journal Article, 2010
• Dermot T. McDowell, Fraser M. Smith, John V. Reynolds, Stephen G. Maher, C. Adida, P. Crotty, Eoin F. Gaffney, Donal Hollywood, B. Mehigan, R. B. Stephens, Michael J. Kennedy., Increased spontaneous apoptosis, but not survivin expression, is associated with histomorphologic response to neoadjuvant chemoradiation in rectal cancer., International Journal of Colorectal Disease, 24, (11), 2009, p1261 - 1269Journal Article, 2009
• Stephen G. Maher, Charles M. Gillham, Shane P. Duggan, Paul C. Smyth, Nicola Miller, Cian Muldoon, Kenneth J. O'Byrne, Orla M. Sheils, Donal Hollywood, John V. Reynolds, Gene expression microarray analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of oesophageal cancer, Annals of Surgery, 250, (5), 2009, p729 - 737Journal Article, 2009
• Stephen G. Maher, Charles M. Gillham, Shane P. Duggan, Paul C. Smyth, Nicola Miller, Cian Muldoon, Kenneth J. O'Byrne, Orla M. Sheils, Donal Hollywood, John V. Reynolds, Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer., Annals of surgery, 250, (5), 2009, p729-37Journal Article, 2009, DOI
• Basic concepts of inflammation and its role in carcinogenesis in, editor(s)Janusz A. Jankowski , Inflammation and Gastrointestinal Carcinogenesis, Springer, 2011, pp1 - 34, [Stephen G. Maher, John V. Reynolds]Book Chapter, 2011
• Niamh Lynam-Lennon, John V. Reynolds, Laure Marignol, Orla M Sheils, Graham P. Pidgeon, Stephen G. Maher, microRNA-31 modulates tumor sensitivity to radiation in esophageal cancer through the regulation of DNA repair genes, Journal of Molecular Medicine, 90, 2012, p1449 - 1458Journal Article, 2012
• Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711Journal Article, 2010, DOI
• Stephen G. Maher, Dermot T. McDowell, Ben C. Collins, Cian Muldoon, William M. Gallagher, John V. Reynolds, Serum proteomic profiling reveals that pre-treatment complement protein levels are predictive of esophageal cancer patient response to neo-adjuvant chemoradiation, Annals of Surgery, 254, (5), 2011, p809 - 817Journal Article, 2011
• Gijsbert J. Hotte, Niamh Lynam-Lennon, John V. Reynolds, Stephen G. Maher, Radiation sensitivity of oesophageal adenocarcinoma: The contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance, Radiation Research, 177, (3), 2012, p272 - 279Journal Article, 2012
• microRNA in Oncogenesis in, editor(s)Trygve Tollefsbol , Epigenetics in Human Disease, Elsevier, 2012, pp89 - 110, [Niamh Lynam-Lennon, Steven G. Gray, Stephen G. Maher]Book Chapter, 2012
• Byrne M, Reynolds JV, O'Donnell JS, Keogan M, White B, Byrne M, Murphy S, Maher SG, Pidgeon GP, Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery., British Journal of Cancer, 102, (1), 2010, p73-9Journal Article, 2010, DOI , URL , TARA - Full Text
• Maher SG, Reynolds JV, Basic concepts of inflammation and its role in carcinogenesis., Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, 185, 2011, p1-34Journal Article, 2011, DOI
• Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012Journal Article, 2012, DOI
• Picardo SL, Maher SG, O'Sullivan JN, Reynolds JV, Barrett's to oesophageal cancer sequence: a model of inflammatory-driven upper gastrointestinal cancer., Digestive surgery, 29, (3), 2012, p251-60Journal Article, 2012, DOI
• Lynam-Lennon, N., Maher, S.G., Maguire, A., (...), Reynolds, J.V., O'Sullivan, J., Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE , 9, (6), 2014, pe100738-Journal Article, 2014, DOI , TARA - Full Text

• Maher SG, Reynolds JV, Oesophageal cancer: The potential of modern molecular tools in treatment, Cancer Professional, 6, 2012, p21 - 25Review Article
• Cawthorne C, Maher SG, Ahmed N, Beavis AW, Improving the application of PET to radiotherapy via preclinical research: status and potential, RAD Magazine, 42, (492), 2016, p29 - 30Review Article
• Stephen Maher, MicroRNAs as modulators of therapeutic sensitivity, MicroRNA Europe Annual Conference, Cambridge, UK, 2016, 2016Oral Presentation
• Stephen Maher, Cancer - The Patient Journey, 60th London International Youth Science Forum, London, UK, 2018, 2018Oral Presentation
• Maher SG, Modelling radioresistance in vitro, The role of radiotherapy in a stratified approach to the treatment of oesophageal cancer, London - Cambridge University, 10 June 2019, 2019Invited Talk
• Maher SG, Point-of-care testing versus lab-based testing - striking a balance, Konstanz, Germany, 2021, BioLagoInvited Talk
• Kane LE, Mellotte GS, Mylod E, O'Brien RM, O'Connell F, Buckley CE, Arlow J, Nguyen K, Mockler D, Meade AD, Ryan BM, Maher SG, Diagnostic accuracy of blood-based biomarkers for pancreatic cancer: A systematic review and meta-analysis, Cancer Research, 2021, 2021, pp6 - 7Poster

Stephen has always been interested in cancer and its treatment. Having completed a PhD that examined T cell biology and interleukin-2 therapy for melanoma and renal cell carcinoma, he moved the the National Cancer Institute in the USA to pursue postdoctoral studies in the anti-tumour potential of a newly discovered cytokine, interferon-lambda (IL-29). Over the past 15 years his research interests have largely focused on understanding and predicting tumour response and resistance to more conventional, broadly applicable, cancer treatments, specifically chemotherapy and radiotherapy. Stephen's group examines the influence of the microRNA compartment, DNA damage response and, more recently hypoxia, on regulating cellular sensitivity to chemotherapy and radiotherapy in oesophageal and mesothelial tumours. His team is internationally recognised as leaders in translational radiotherapy research. More recently he initiated and leads an award-winning pancreatic cancer research programme. Being a member of the department of surgery at TTMI, based at St. James's Hospital in Dublin, his work is highly patient centric.

• Title

  Validation of a panel of novel radiosensitising agents for cancer
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  2019
  Date To

  2020
• Title

  Targeting IL-6 in the obese tumour microenvironment to overcome chemotherapy and radiotherapy resistance in oesophageal adenocarcinoma
  Summary
  Funding Agency

  HRCI/HRB
  Date From

  2020
  Date To

  2023
• Title

  Investigating novel cancer immunotherapies in upper gastrointestinal cancers and the impact of combination chemotherapy
  Summary
  Funding Agency

  Irish Research Council
  Date From

  2017
  Date To

  2021
• Title

  The use of liquid biopsy in patients with pancreatic cystic lesions
  Summary
  Funding Agency

  Meath Foundation
  Date From

  2019
  Date To

  2022
• Title

  The role of microRNA and random mitochondrial DNA mutations in a novel clinically-relevant isogenic model of radioresistance in oesophageal adenocarcinoma
  Summary
  Funding Agency

  Health Research Board
  Date From

  2011
  Date To

  2013
• Title

  The role of the chemokine CCL28 (MEC) in oesophageal adenocarcinoma progression: interaction between the immune system and the tumour
  Summary
  Funding Agency

  Irish Cancer Society
  Date From

  2010
  Date To

  2013
• Title

  A MicroRNA-based replacement therapy for chemoradiosensitising oesophageal cancer
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  2020
  Date To

  2021
• Title

  Tissue and Serum microRNA signatures for predicting response to chemoradiotherapy for oesophageal adenocarcinoma
  Summary
  Funding Agency

  Irish Cancer Society
  Date From

  2010
  Date To

  2013
• Title

  The role of a cancer stem-like cells in an isogenic model of radioresistance in oesphageal adenocarcinoma
  Summary
  Funding Agency

  Health Research Board
  Date From

  2012
  Date To

  2016
• Title

  Development of a novel bioscaffold for radiosensitising microRNA delivery in cancer
  Summary
  Funding Agency

  Wellcome Trust-HRB-SFI
  Date From

  2017
  Date To

  2018
• Title

  Development of a hydrogel system for delivery microRNA in vivo
  Summary
  Funding Agency

  Trinity College Dublin
  Date From

  2017
  Date To

  2018
• Title

  Mechanisms underpinning miR-31 mediated chemoresistance in MPM
  Summary
  Funding Agency

  Kazan McClane Partners
  Date From

  2017
  Date To

  2018
• Title

  The role of miR-330 and miR-187 in regulating sensitivity to chemoradiation in oeosphageal adenocarcinoma
  Summary
  Funding Agency

  Cancer and Polio Research Fund UK
  Date From

  2013
  Date To

  2015
• Title

  The role of microRNA-31 in regulating therapeutic sensitivity in pancreatic adenocarcinoma
  Summary
  Funding Agency

  Trinity College Dublin
  Date From

  2018
  Date To

  2022
• Title

  The role of miR-187 as a radiosensitiser in oesophageal cancer
  Summary
  Funding Agency

  University of Hull
  Date From

  2015
  Date To

  2019
• Title

  The role of miR-187 as a radiosensitiser in oesophageal cancer
  Summary
  Funding Agency

  Cancer and Polio Research Fund UK
  Date From

  2016
  Date To

  2019
• Title

  Hull York Medical School PhD Project stimulus
  Summary
  Funding Agency

  Hull York Medical School
  Date From

  2013
  Date To

  2016
• Title

  Upgrade and installation of a new radiotherapy and radiobiology core
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  2017
  Date To

  2022
• Title

  Development of translational radiotherapy research in the East Yorkshire region
  Summary
  Funding Agency

  Help for Health UK and Castle Hill Hospital Cancer Trust Fund
  Date From

  2014
  Date To

  2019

Gastroenterology & Hepatology, Other Basic Medicine, Other Basic Medicine, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics), Health Care & Health Services (including Health Technology and Health Information Systems), Oncology and cancer biology, Gastroenterology & Hepatology, Health Care & Health Services (including Health Technology and Health Information Systems), Oncology and cancer biology, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics),

• 1st Prize, TCD Molecular Medicine Entrepreneurship Course 2009
• Fellowship, National Cancer Institute (USA) 2004
• Patrick G. Johnston Award - Irish Association of Cancer Research (supervisor) 2021
• Travel Award, St. James's Hospital Dublin 2009
• Irish Lab Awards - Research Lab of the Year 2019
• 1st Prize, Best Research Paper, 11th Annual International Medical Postgraduate Conference, Charles University in Prague (Supervisor) 2014
• Biochemical Society Summer Studentship (Supervisor) 2013
• 1st Prize, Best Research Paper, 12th Annual International Medical Postgraduate Conference, Charles University in Prague (Supervisor) 2015
• NCRI Hamilton-Fairley Young Investigator Awards (double-shortlisting) (Supervisor) 2015
• 1st prize - best scientific paper - Irish Society of Gastroenterology (supervisor) 2021
• Donald Weir Medal for Research, Trinity College Dublin 2008
• Oncology Scholars Travel Award, Irish Cancer Society 2008
• Researcher of the Year, Irish Cancer Society 2013
• 1st prize - best poster - TSJCI 11th International Cancer Conference (supervisor) 2019
• Association of Radiation Research (ARR) SIT bursary (supervisor) 2017
• Researcher of the Year, Hull York Medical School (Supervisor) 2016
• Patey Prize, SARS Annual Meeting 2011
• Roche Researcher of the Year, TCD (Supervisor) 2010
• Irish Representative at 39th LIYSF 1997
• 1st Prize, Best Poster, UK Radiation Oncology (UKRO) Annual Meeting (Supervisor) 2015
• 1st prize - best basic science paper - iCHAMS international conference (supervisor) 2022
• Poster Prize, 7th International Cancer Conference (Dublin) 2009
• Fellowship, Irish Cancer Society 2010
• iMig Young Investigator Award (Supervisor) 2016

• British Association of Cancer Research (BACR) Present
• Irish Association of Radiation Research (IRRS) Present
• Mesothelioma Research Network (MRN) present
• Association of Radiation Research (UK) Present
• Irish Association of Cancer Research (IACR) Present
• Clinical Trials Ireland (formerly ICORG) present
• Biochemical Society UK Present
• British Lung Foundation 2016
• American Association of Cancer Research (AACR): Associate Member Present
• European Association of Cancer Research (EACR) Present
• International Society for Interferon and Cytokine Research (ISICR) 2009

• Editorial Board, Frontiers in Cell and Developmental Biology - Associate Editor 2018
• Editorial Board, Frontiers in Oncology - Associate Editor - Molecular and Cellular Oncology 2017
• Editorial Board, Frontiers in Oncology - Associate Editor - Molecular and Cellular Oncology 2017
• Editorial Board, Frontiers in Cell and Developmental Biology - Associate Editor 2018