Medicine

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Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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Dr. Niamh Lynam-Lennon

Dr. Niamh Lynam-Lennon

Senior Research Fellow, Surgery


Publications and Further Research Outputs

  • Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J., Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC Cancer, 3, (14), 2014, p907-Journal Article, 2014, TARA - Full Text
  • Lynam-Lennon N, Connaughton R, Carr E, Mongan AM, O'Farrell NJ, Porter RK, Brennan L, Pidgeon GP, Lysaght J, Reynolds JV, O'Sullivan J, Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma., BMC cancer, 14, 2014, p907Journal Article, 2014, DOI , TARA - Full Text
  • Phelan JJ, MacCarthy F, Feighery R, O'Farrell NJ, Lynam-Lennon N, Doyle B, O'Toole D, Ravi N, Reynolds JV, O'Sullivan J, Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus., Cancer letters, 354, (1), 2014, p122-31Journal Article, 2014, DOI , TARA - Full Text
  • Lynam-Lennon N, Maher SG, Maguire A, Phelan J, Muldoon C, Reynolds JV, O'Sullivan J, Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma., PloS one, 9, (6), 2014, pe100738Journal Article, 2014, DOI , TARA - Full Text
  • Mongan AM, Lynam-Lennon N, Casey R, Maher S, Pidgeon G, Reynolds JV, O'Sullivan J, Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma., Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2015Journal Article, 2015
  • Casey JP, McGettigan P, Lynam-Lennon N, McDermott M, Regan R, Conroy J, Bourke B, O'Sullivan J, Crushell E, Lynch S, Ennis S, Identification of a mutation in LARS as a novel cause of infantile hepatopathy., Molecular genetics and metabolism, 106, (3), 2012, p351-8Journal Article, 2012, DOI
  • Lynam-Lennon N, Maher SG, Reynolds JV, The roles of microRNA in cancer and apoptosis., Biological reviews of the Cambridge Philosophical Society, 84, (1), 2009, p55-71Journal Article, 2009
  • MicroRNA in Oncogenesis in, editor(s)Trygve Tollefsbo , Epigenetics in Human Disease, Elsevier, 2012, pp89 - 110, [Lynam-Lennon N, Gray SG and Maher SG]Book Chapter, 2012
  • McDermott N., Meunier A., Mooney B., Nortey G., Hernandez C., Hurley S., Hurley S., Lynam-Lennon N., Barsoom S., Bowman K., Marples B., Jones G., Marignol L., Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells, Scientific Reports, 6, 2016Journal Article, 2016, DOI
  • Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397Journal Article, 2016, DOI
  • O'Farrell N.J, Feighery R, Picardo S.L, Lynam-Lennon N, Biniecka M, McGarrigle S.A, Phelan J.J, MacCarthy F, O'Toole D, Fox E.J, Ravi N, Reynolds J.V, O'Sullivan J, Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence, BMC Cancer, 16, (1), 2016, p497-Journal Article, 2016, DOI , URL , TARA - Full Text
  • Lynam-Lennon N, Heavey S, Sommerville G, Bibby BA, Ffrench B, Quinn J, Gasch C, O'Leary JJ, Gallagher MF, Reynolds JV, Maher SG, MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype, Oncotarget, 8, (7), 2017, p11400 - 11413Journal Article, 2017, DOI , TARA - Full Text
  • Matchett K.B, Lynam-Lennon N, William Watson R, Brown J.A.L, Advances in precision medicine: Tailoring individualized therapies, Cancers, 9, (11), 2017, p146Journal Article, 2017, DOI , URL
  • Brown J.A.L, Chonghaile T.N, Matchett K.B, Lynam-Lennon N, Kiely P.A, Big data-led cancer research, application, and insights, Cancer Research, 76, (21), 2016, p6167 - 6170Journal Article, 2016, DOI , URL
  • Mongan, A.M., Lynam-Lennon, N., Casey, R., Maher, S., Pidgeon, G., Reynolds, J.V., O"Sullivan, J., Erratum to: Visceral obesity stimulates anaphase bridge formation and spindle assembly checkpoint dysregulation in radioresistant oesophageal adenocarcinoma, Clinical and Translational Oncology, 2015Journal Article, 2015
  • Buckley AM, Lynam-Lennon N, Kennedy SA, Dunne MR, Aird JJ, Foley EK, Clarke N, Ravi N, O'Toole D, Reynolds JV, Kennedy BN, O'Sullivan J., Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma., Oncotarget, 9, (72), 2018, p33634-33647Journal Article, 2018, DOI , TARA - Full Text
  • Buckley AM, Dunne MR, Lynam-Lennon N, Kennedy SA, Cannon A, Reynolds AL, Maher SG, Reynolds JV, Kennedy BN, O'Sullivan J., Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma., Cancer letters, 447, 2019, p115-129Journal Article, 2019, DOI
  • Mongan AM, Lynam-Lennon N, Doyle SL, Casey R, Carr E, Cannon A, Conroy MJ, Pidgeon GP, Brennan L, Lysaght J, Reynolds JV, O'Sullivan J., Visceral Adipose Tissue Modulates Radiosensitivity in Oesophageal Adenocarcinoma., International journal of medical sciences, 16, (4), 2019, p519-528Journal Article, 2019, DOI , TARA - Full Text
  • Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236Journal Article, 2022
  • Rebecca Amet, Viola Previtali, Helene B. Mihigo, Emily Sheridan, Sarah Brophy , Nadhim Kamil Hante, Maria Jose Santos-Martinez, Patrick J. Hayden, Paul V. Browne, Isabel Rozas, Anthony M. McElligott , Daniela M. Zisterer , A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma , Life Sciences, 290, 2022Journal Article, 2022, DOI , TARA - Full Text
  • Davern M, Fitzgerald MC, Buckley CE, Heeran AB, Donlon NE, McGrath J, O'Connell F, Deshpande MR, Hayes C, MacDonald J, Sheppard AD, Reynolds JV, Maher SG, Lynam-Lennon N, Murphy B, Lysaght J, PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming resistance to PD-1 blockade in hypoxic tumours, Cancer Letters, 2022Journal Article, 2022
  • Aoife Branagan, Niofa Canty, Evanne O'Halloran, Marian Madden, Michael Brendan O'Neill, Evaluation of the Quick Wee method of inducing faster clean catch urine collection in pre-continent infants: a randomized controlled trial, World Journal of Pediatrics , 2022Journal Article, 2022, DOI
  • Aoife Branagan, Caoimhe S. Costigan, Maria Stack, Cara Slagle, Eleanor J. Molloy, Management of Acute Kidney Injury in Extremely Low Birth Weight Infants, Frontiers in Pediatrics , 2022Journal Article, 2022, DOI
  • Davern M, O' Brien RM, McGrath J, Donlon NE, Melo AM, Buckley CE, Sheppard AD, Reynolds JV, Lynam-Lennon N, Maher SG, Lysaght J., PD-1 blockade enhances chemotherapy toxicity in oesophageal adenocarcinoma., Scientific Reports, 12, (1), 2022, p3259-Journal Article, 2022
  • Donlon NE, Davern M, O'Connell F, Sheppard A, Heeran A, Bhardwaj A, Butler C, Narayanasamy R, Donohoe C, Phelan JJ, Lynam-Lennon N, Dunne MR, Maher S, O'Sullivan J, Reynolds JV, Lysaght J., Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma, World Journal of Gastroenterology, 2022Journal Article, 2022
  • O'Gorman P, Laubach JP, O'Dwyer ME, Krawczyk J, Yee AJ, Gilligan O, Cahill MR, Rosenblatt J, Quinn J, Murphy PT, DiPietro H, Perera MR, Crotty GM, Cummings K, Hayden PJ, Browne P, Savell A, O'Leary HM, O'Keeffe D, Masone K, Hennessy BJ, Guerrero Garcia T, Scott K, Saeed K, Bianchi G, Dowling P, Tierney C, Richardson PG., Phase 2 studies of lenalidomide, subcutaneous bortezomib, and dexamethasone as induction therapy in patients with newly diagnosed multiple myeloma., American journal of hematology, 97, (5), 2022, p562-573Journal Article, 2022, DOI
  • Masouridi-Levrat S, Olavarria E, Iacobelli S, Aljurf M, Morozova E, Niittyvuopio R, Sengeloev H, Reményi P, Helbig G, Browne P, Ganser A, Nagler A, Snowden JA, Robin M, Passweg J, Van Gorkom G, Wallet HL, Hoek J, Blok HJ, De Witte T, Kroeger N, Hayden P, Chalandon Y, Agha IY., Outcomes and toxicity of allogeneic hematopoietic cell transplantation in chronic myeloid leukemia patients previously treated with second-generation tyrosine kinase inhibitors: a prospective non-interventional study from the Chronic Malignancy Working Party of the EBMT., Bone marrow transplantation, 57, (1), 2022, p23-30Journal Article, 2022, DOI
  • O'Brien R.M., Lynam-Lennon N., Olcina M.M., Thinking inside the box: intracellular roles for complement system proteins come into focus, British Journal of Cancer, 128, (2), 2023, p165 - 167, p165-167Journal Article, 2023, DOI
  • Kennedy S.P., Treacy O., Allott E.H., Eustace A.J., Lynam-Lennon N., Buckley N., Robson T., Precision Medicine and Novel Therapeutic Strategies in Detection and Treatment of Cancer: Highlights from the 58th IACR Annual Conference, Cancers, 14, (24), 2022Journal Article, 2022, DOI
  • Molloy E.J., El-Dib M., Juul S.E., Benders M., Gonzalez F., Bearer C., Wu Y.W., Robertson N.J., Hurley T., Branagan A., Michael Cotten C., Tan S., Laptook A., Austin T., Mohammad K., Rogers E., Luyt K., Bonifacio S., Soul J.S., Gunn A.J., Bonifacio S., Wintermark P., Aly H., Chang T., Chau V., Glass H., Lemmon M., Massaro A., Wusthoff C., deVeber G., Pardo A., McCaul M.C., Neuroprotective therapies in the NICU in term infants: present and future, Pediatric Research, 2022Journal Article, 2022, DOI
  • Branagan A., Yu I., Gurusamy K., Miletin J., Thresholds for surfactant use in preterm neonates: a network meta-analysis, Archives of Disease in Childhood: Fetal and Neonatal Edition, 2022Journal Article, 2022, DOI
  • Abend N., Adams E., Al Balushi A., Alburaki W., Appendino J., Barbosa V.S., Birca A., Bonifacio S., Branagan A., Chang T., Chowdhury R., Christou H., Chu C., Cilio M.R., Comani S., Corsi-Cabrera M., Croce P., Cubero-Rego L., Dawoud F., de Vries L., Dehaes M., Devane D., Duncan A., El Ters N., El-Dib M., Elshibiny H., Esser M., Fairchild K., Finucane E., Franceschini M.A., Gallagher A., Ghosh A., Glass H., Venkata S.K.R.G., Baillet T.H., Herzberg E., Hildrey E., Hurley T., Inder T., Jacobs E., Jefferies K., Jermendy A., Khazaei M., Kilmartin K., King G., Lauronen L., Lee S., Leijser L., Lind J., Llaguno N.S., Machie M., Magalhaes M., Mahdi Z., Maluomi J., Marandyuk B., Massey S., McCulloch C., Metsaranta M., Mikkonen K., Mohammad K., Molloy E., Momin S., Munster C., Murthy P., Netto A., Nevalainen P., Nguyen J., Nieves M., Nyman J., Oliver N., Peeters C., Pietrobom R.F.R., Pijpers J., Pinchefksy E., Ping Y.B., Quirke F., Raeisi K., Ricardo-Garcell J., Robinson J., Rodrigues D.P., Rosati J., Scott J., Scringer-Wilkes M., Shellhaas R., Smit L., Soul J., Srivastava A., Steggerda S., Sunwoo J., Szakmar E., Tamburro G., Thomas S., Toiviainen-Salo S., Toma A.I., Vanhatalo S., Variane G.F.T., Vein A., Vesoulis Z., Vilan A., Volpe J., Weeke L., Wintermark P., Wusthoff C., Zappasodi F., Zein H., Zempel J., Proceedings of the 13th International Newborn Brain Conference: Neonatal Neurocritical Care, Seizures, and Continuous EEG monitoring, Journal of neonatal-perinatal medicine, 15, (2), 2022, p467 - 485, p467-485Journal Article, 2022, DOI
  • Treston B.P., Semberova J., Kernan R., Crothers E., Branagan A., O'Cathain N., Miletin J., Assessment of neonatal heart rate immediately after birth using digital stethoscope, handheld ultrasound and electrocardiography: An observational cohort study, Archives of Disease in Childhood: Fetal and Neonatal Edition, 104, (2), 2019, pF227-Journal Article, 2019, DOI
  • Waszczuk-Gajda A., Penack O., Sbianchi G., Koster L., Blaise D., Remenyi P., Russell N., Ljungman P., Trneny M., Mayer J., Iacobelli S., Kobbe G., Scheid C., Apperley J., Touzeau C., Lenhoff S., Jantunen E., Anagnostopoulos A., Paris L., Browne P., Thieblemont C., Schaap N., Sierra J., Yakoub-Agha I., Garderet L., Styczynski J., Schoemans H., Moiseev I., Duarte R.F., Peric Z., Montoto S., van Biezen A., Mikulska M., Aljurf M., Ruutu T., Kroger N., Morris C., Koenecke C., Schoenland S., Basak G.W., Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study, Journal of Clinical Medicine, 11, (12), 2022Journal Article, 2022, DOI
  • Domingo-Domenech E., Duarte R.F., Boumedil A., Onida F., Gabriel I., Finel H., Arcese W., Browne P., Beelen D., Kobbe G., Veelken H., Arranz R., Greinix H., Lenhoff S., Poire X., Ribera J.M., Thompson J., Zuckerman T., Mufti G.J., Cortelezzi A., Olavarria E., Dreger P., Sureda A., Montoto S., Allogeneic hematopoietic stem cell transplantation for advanced mycosis fungoides and Sézary syndrome. An updated experience of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation, Bone Marrow Transplantation, 56, (6), 2021, p1391 - 1401, p1391-1401Journal Article, 2021, DOI
  • Lawless S., Sbianchi G., Morris C., Iacobelli S., Bosman P., Blaise D., Remenyi P., Byrne J.L., Mayer J., Apperley J., Lund J., Kobbe G., Schaap N., Isaksson C., Lenhoff S., Basak G., Touzeau C., Wilson K.M.O., Gonzalez Muniz S., Scheid C., Browne P., Anagnostopoulos A., Rambaldi A., Jantunen E., Kroger N., Schonland S., Yakoub-Agha I., Garderet L., IgD Subtype But Not IgM or Non-Secretory Is a Prognostic Marker for Poor Survival Following Autologous Hematopoietic Cell Transplantation in Multiple Myeloma. Results From the EBMT CALM (Collaboration to Collect Autologous Transplant Outcomes in Lymphomas and Myeloma) Study, Clinical Lymphoma, Myeloma and Leukemia, 21, (10), 2021, p686 - 693, p686-693Journal Article, 2021, DOI
  • Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711Journal Article, 2010, DOI
  • Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012Journal Article, 2012, DOI
  • Hötte GJ, Linam-Lennon N, Reynolds JV, Maher SG, Radiation sensitivity of esophageal adenocarcinoma: the contribution of the RNA-binding protein RNPC1 and p21-mediated cell cycle arrest to radioresistance., Radiation research, 177, (3), 2012, p272-9Journal Article, 2012, DOI
  • Lynam-Lennon, N., Maher, S.G., Maguire, A., (...), Reynolds, J.V., O'Sullivan, J., Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma, PLoS ONE , 9, (6), 2014, pe100738-Journal Article, 2014, DOI , TARA - Full Text
  • A Branagan, L Perrem, J Semberova, A O'Sullivan, J Miletin, A Doolan, Central catheter removal timing and growth patterns in preterm infants, European Journal of Clinical Nutrition , 2020Journal Article, DOI