Medicine

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Level 1
Trinity Biomedical Sciences Institute
Trinity College
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Dr Linda O'Neill

Dr Linda O'Neill

Postdoctoral Research Fellow and Project Manager


Dr Linda O'Neill is a Research Fellow with the Trinity Exercise Oncology Research Group. She is a registered physiotherapist and member of the Irish Society of Chartered Physiotherapists (ISCP).

Dr O'Neill completed her PhD in 2018 which investigated the efficacy of multidisciplinary rehabilitation in oesophago-gastric cancer survivorship. She also holds a Bachelor of Science (BSc.) in Physiotherapy (RCSI), a Masters (MSc.) in Respiratory Physiotherapy (TCD), a Post-graduate Certificate in Statistics (TCD), and a Special Purpose Certificate in Teaching, Learning, and Assessment for Academic Practice (TCD).

She has a keen research interest in exercise oncology, in particular exercise in cancer survivorship. Her work has been widely published and she has presented at conferences both nationally and internationally. She currently works as a Project Manager on the HRB/MRCG funded Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus (PRE-HIIT) trial and the HRB funded Rehabilitation Strategies following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStORe II) trial. Recently, she has become very involved in trial methodology research, and currently leads an embedded SWAT in the ReStORe II trial. She is a Research Associate with the HRB-TMRN, member of the NIHR-TMRP Trial Conduct Working Group, and is currently co-lead of the TMRP Trial Conduct Working Group-Retention Topic Group

Professionally Dr O'Neill has held a number of clinical and educational roles. Clinically she has gained experience in a variety of areas including care of the elderly, rheumatology, cardiorespiratory, and oncology. In recent years she has contributed to undergraduate and post graduate teaching at Trinity College Dublin and Singapore Institute of Technology. She has also previously worked as a Special Lecturer/ Clinical Tutor on the Professional Masters in Physiotherapy Programme at University College Dublin. She is an active member of the ISCP, and in recent years has held officer roles on both the Eastern Branch committee and the Chartered Physiotherapists in Oncology and Palliative Care Clinical Interest Group.

Publications and Further Research Outputs

  • Guinan, E.M., Doyle, S.L., O'Neill, L., Dunne, M.R., Foley, E.K., O'Sullivan, J., Reynolds, J.V., Hussey, J., Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study, Supportive Care in Cancer, 25, (3), 2016, p749 - 756Journal Article, 2016, DOI
  • Guinan, E.M., Doyle, S.L., Bennett, A.E., O'Neill, L, Gannon, J., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance, Supportive Care in Cancer, 26, (5), 2018, p1569 - 1576Journal Article, 2018, DOI , URL
  • Sheill G, Guinan E, Neill LO, Hevey D, Hussey J, The views of patients with metastatic prostate cancer towards physical activity: a qualitative exploration, Supportive Care in Cancer, 26, (6), 2017, p1747 - 1754Journal Article, 2017, DOI
  • O'Neill L, Gannon J, Guinan E, Reynolds JV, Hussey J. , Multidisciplinary rehabilitation across the esophageal cancer journey, Journal of Thoracic Diseases, 9, (12), 2017, pE1140 - E1142Journal Article, 2017, DOI , TARA - Full Text
  • Sheill G, Guinan E, O Neill L., Hevey D., Hussey J. , Physical Activity and Advanced Cancer: The views of Oncology and Palliative Care Physicians in Ireland. , Irish Journal of Medical Science, 187, (2), 2018, p337 - 343Journal Article, 2018, DOI
  • Sheill. G., Guinan, E.M., O'Neill L, Hevey, D., Hussey, J. , Physical Activity and Advanced Cancer: The views of Chartered Physiotherapists in Ireland. , Physiotherapy Theory and Practice, 3, 2018, p1 - 8Journal Article, 2018, DOI
  • Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E.M., Boland, L., Doyle, S.L., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer, Supportive Care in Cancer, 26, (8), 2018, p2615 - 2623Journal Article, 2018, DOI , URL
  • O'Neill, L.M., Guinan, E., Doyle, S.L., Bennett, A.E., Murphy, C., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., Hussey, J., The RESTORE Randomized Controlled Trial: Impact of a multidisciplinary rehabilitative program on cardiorespiratory fitness in esophagogastric cancer survivorship, Annals of Surgery, 268, (5), 2018, p747 - 755Journal Article, 2018, DOI , URL
  • O'Neill, L. and Moran, J. and Guinan, E.M. and Reynolds, J.V. and Hussey, J., Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review, Journal of Cancer Survivorship, 12, (4), 2018, p601 - 618Journal Article, 2018, DOI , URL
  • Guinan EM, Forde C, O'Neill L, Gannon J, Doyle SL, Valkenet K, Trappenburg JCA, van Hillegersberg R, Ravi N, Hussey JM, Reynolds JV., Effect of preoperative inspiratory muscle training on physical functioning following esophagectomy., Diseases of the Esphagus, 32, (32), 2018, pdoy091-Journal Article, 2018, DOI
  • Linda O'Neill, Emer Guinan, Suzanne L Doyle, Jessie A. Elliott, Jacintha O'Sullivan, John V. Reynolds, Juliette Hussey, Rehabilitation Strategies following esophageal cancer (the ReStOre trial): a feasibility study, Diseases of the Esophagus, 30, (5), 2017, p1 - 8Journal Article, 2017, DOI
  • Guinan, E.M., Bennett, A.E., Doyle, S.L., O'Neill, L, Gannon, J., Foley, G., Elliott, J.A., O'Sullivan, J., Reynolds, J.V., & Hussey, J., Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study, BMC Cancer, 19, (682), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
  • O'Neill, L.M., Bennett, A.E., Guinan, E., Reynolds, J.V., Hussey, J., Physical recovery in the first six months following oesophago-gastric cancer surgery. Identifying rehabilitative needs: a qualitative interview study, Disability and Rehabilitation, 2019, p1-8Journal Article, 2019, DOI , URL
  • O'Neill L., Knapp P., Doyle SL., Guinan E., Parker A.,Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, 'Patient and family co-developed participant information to improve recruitment rates, retention, and patient understanding in the Rehabilitation Strategies Following Oesophago-gastric and Hepatopancreaticobiliary Cancer (ReStOre II) trial: Protocol for a study within a trial (SWAT) [version 1; peer review: awaiting peer review]', 2019, -Protocol or guideline, 2019, DOI
  • O'Neill L., Reynolds S., Sheill G., Guinan E., Mockler D., Geoghegan J., Conlon K., Reynolds, J.V., Hussey J., Physical function in patients with resectable cancer of the pancreas and liver-a systematic review, Journal of Cancer Survivorship, 2020Journal Article, 2020, DOI
  • Sheill G., Guinan E., O'Neill L., Normand C., Doyle SL., Moore S., Newell J., McDermott G., Ryan R., Reynolds JV., Hussey J., Preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus (PREHIIT): protocol for a randomized controlled trial, BMC Cancer, 2020Journal Article, 2020, DOI
  • O'NEILL L., GUINAN E., DOYLE S., CONNOLLY D., O'SULLIVAN J., BENNETT A., SHEILL G., SEGURADO R., KNAPP P., FAIRMAN C., NORMAND C., GEOGHEGAN J., CONLON K., REYNOLDS JV., HUSSEY J., Rehabilitation strategies following oesophagogastric and hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomised controlled trial, BMC Cancer, 20, 2020, p1 - 20Journal Article, 2020, DOI
  • Sheill G., Reynolds S., O'Neill L., Mockler D., Reynolds JV., Hussey J., Guinan E.,, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, Cardiopulmonary Exercise Testing in Oesophagogastric Surgery: a Systematic Review, 2020, p12Journal Article, 2020, DOI
  • O'Neill L., Guinan E., Doyle S., O'Connor L., Sheill G., Smyth E., Fairman C., Segurado R., Connolly D., O'Sullivan J., Reynolds JV., Hussey J, ReStOre@Home: Feasibility study of a virtually delivered 12-week multidisciplinary rehabilitation programme for survivors of upper gastrointestinal (UGI) cancer - study protocol, HRB Open Research, 2020Journal Article, 2020, DOI
  • Bennett, A.E., O'Neill, L., Connolly, D., Guinan, E., Boland, L., Doyle, S., O'Sullivan, J., Reynolds, J.V., Hussey, J., Perspectives of Esophageal Cancer Survivors on Diagnosis, Treatment, and Recovery., Cancers, 13, (1), 2021, p1-12Journal Article, 2021, DOI , URL
  • Grainne Sheill, Emer Guinan, Linda O'Neill, Emily Smyth, Charles Normand, Suzanne L. Doyle, Sarah Moore, John Newell, Grainne McDermott, Ronan Ryan, John V. Reynolds, Juliette Hussey, Prehabilitation during a pandemic: preoperative exercise to improve fitness in patients undergoing complex surgery for cancer of the lung or oesophagus, the PRE-HIIT trial: an updated study protocol, HRB Open Research, 4, 2021, p4Journal Article, 2021, TARA - Full Text
  • O'Connor, L., Smyth, E., Bennett, A.E.. Smith, V., O'Neill, L., Reynolds, J.V.,. Hussey, J., Guinan, E.M., Identifying outcomes reported in exercise interventions in oesophagogastric cancer survivors: a systematic review, BMC Cancer, 21, (586), 2021, p1-9Journal Article, 2021, DOI , URL
  • Kennedy, S.A., Annett, S.L., Dunne, M.R., Boland, F., O'Neill, L.M., Guinan, E.M., Doyle, S.L., Foley, E.K., Elliott, J.A., Murphy, C.F., Bennett, A.E., Carey, M., Hillary, D., Robson, T., Reynolds, J.V., Hussey, J., O'Sullivan, J.N., Effect of the Rehabilitation Program, ReStOre, on Serum Biomarkers in a Randomized Control Trial of Esophagogastric Cancer Survivors, Frontiers in Oncology, 11, (669078), 2021, p1-11Journal Article, 2021, DOI
  • ALKHAFFAF B., BLAZEBY JM, ET AL AND ON BEHALF OF THE GASTROS INTERNATIONAL WORKING GROUP, Methods for conducting international Delphi surveys to optimise global participation in core outcome set development: a case study in gastric cancer informed by a comprehensive literature review, Trials, 2021, phttps://doi.org/10.1186/s13063Journal Article, 2021
  • Sheill G., Hennessy M., O'Neill L., Reynolds S., Towns J., Gill M., Guinan E., Exercise and chronic health conditions in the community: A qualitative Study of Patients and Fitness instructors, Health and Social Care in the Community, 2021Journal Article, 2021, DOI
  • Brennan, L. Sheill, G. O'Neill, L, O'Connor, L, Smyth, E. Guinan, E, Physical Therapists in Oncology Settings: Experiences in Delivering Cancer Rehabilitation Services, Barriers to Care, and Service Development Needs, Physical Therapy, 2022Journal Article, 2022, DOI
  • Brennan, L., Sadeghi, F., O'Neill, L., Guinan, E., Smyth, L. Sheill, G., Smyth, E., Doyle, S.L., Timon, C., Connolly, D., O'Sullivan, J., Reynolds, J.V., and Hussey, J., Telehealth Delivery of a Multi-Disciplinary Rehabilitation Programme for Upper Gastro-Intestinal Cancer: ReStOre@Home Feasibility Study, Cancers, 2022Journal Article, 2022, DOI
  • B Alkhaffaf, A Metryka, J M Blazeby, A -M Glenny, A Adeyeye, P M Costa, I Diez del Val, S S Gisbertz, A Guner, S Law, H -J Lee, Z Li, K Nakada, D Reim, P Vorwald, G L Baiocchi, W Allum, M A Chaudry, E A Griffiths, P R Williamson, I A Bruce, on behalf of the GASTROS International Working Group, Core outcome set for surgical trials in gastric cancer (GASTROS study): international patient and healthcare professional consensus., British Journal of Surgery, 2021Journal Article, 2021, URL
  • Alkhaffaf B, Metryka A, Blazeby JM, Glenny A-M, Williamson PR, Bruce IA, et al, How are trial outcomes prioritised by stakeholders from different regions? Analysis of an international Delphi survey to develop a core outcome set in gastric cancer surgery., PlOs One, 2021Journal Article, 2021, URL
  • REYNOLDS SA., O'CONNOR L., McGEE A., QUINN KILCOYNE A., CONNOLLY A., MOCKLER D., GUINAN E., O'NEILL L, Recruitment rates and strategies in exercise trials in cancer survivorship: a systematic review, Journal of Cancer Survivorship, 2023Journal Article, 2023, DOI
  • O'Brien, A., Brennan, L., O'Neill, L, Guinan, E., Connolly, D., Reynolds, JV., and Hussey, J., Patient Experiences of a Telehealth Multidisciplinary Cancer Rehabilitation Programme: Qualitative Findings from the ReStOre@Home Feasibility Study, 2023Journal Article, 2023, DOI
  • O'Neill, L., Brennan, L., Sheill, G., Connolly D., Guinan, E., and Hussey, J., Moving Forward With Telehealth in Cancer Rehabilitation: Patient Perspectives From a Mixed Methods Study, JMIR Cancer, 2023Journal Article, 2023, DOI , URL
  • Bennett, A.E., O'Neill, L., Doyle, S.L., Guinan, E.M., O'Sullivan, J., Reynolds, J.V., Hussey, J., Nutrient Intakes and Gastrointestinal Symptoms Among Esophagogastric Cancer Survivors up to 5 Years Post-Surgery, Nutrition and Cancer, 2024, p1-10Journal Article, 2024, DOI , URL
  • Hu S, Guinan E, Mockler D, O'Neill L, Retention rates and reasons for non-retention in exercise oncology trials in the post-treatment phaseâ€"a systematic review, Journal of Cancer Survivorship, 2024Journal Article, 2024
  • Brennan L, Sheill G, Collier S, Browne P, Donohoe C, O' Neill L, Hussey J, Guinan E, Personalised exercise rehabilitation in cancer survivorship: the percs triage and referral system study protocol, BMC Cancer, 24, (1), 2024, p517-Journal Article, 2024
  • O'Neill, L., Murphy, F., Reidy, D., Poisson, C., Hussey, J., and Guinan, E., Development and Initial Implementation of a Clinical Monitoring Strategy in a Non-regulated Trial: a research note from the ReStOre II Trial [version 1; peer review: awaiting peer review], HRB Open Research, 2023Journal Article, URL