Dr. Roisin Mc Mackin

Assistant Professor, Physiology

mcmackro@tcd.ie 3531896 2718 https://www.mcmackinlab.com/

Biography

Dr Roisin McMackin was awarded a PhD in Clinical Medicine in 2021 from Trinity College Dublin for investigation of electrophysiological biomarkers of ALS. This research was undertaken at the Academic Unit of Neurology, where she subsequently continued her research postdoctorally with the support of a prestigious MNDA Non-Clinical Fellowship. Dr McMackin began her role as Assistant Professor in the Discipline of Physiology in October 2022. Dr McMackin's research is supported by the Motor Neurone Disease Association UK, The Irish Health Research Board and Research Motor Neurone, in addition to previous support from the Irish Research Council.

Publications and Further Research Outputs

Peer-Reviewed Publications

McMackin R, Muthuraman M, Groppa S, Babiloni C, Taylor JP, Kiernan MC, Nasseroleslami B, Hardiman O., Measuring network disruption in neurodegenerative diseases: New approaches using signal analysis., Journal of neurology, neurosurgery, and psychiatry, 90, (9), 2019, p1011 - 1020Journal Article, 2019, DOI , TARA - Full Text
McMackin R, Bede P, Pender N, Hardiman O, Nasseroleslami B., Neurophysiological markers of network dysfunction in neurodegenerative diseases, Neuroimage Clin, 22, 2019, p101706-Journal Article, 2019, URL , TARA - Full Text
McMackin R, Dukic S, Broderick M, Iyer PM, Pinto-Grau M, Mohr K, Chipika R, Coffey A, Buxo T, Schuster C, Gavin B, Heverin M, Bede P, Pender N, Lalor EC, Muthuraman M, Hardiman O, Nasseroleslami B, Dysfunction of attention switching networks in amyotrophic lateral sclerosis. , Neuroimage Clin, 22, 2019, p101707-Journal Article, 2019, DOI , TARA - Full Text
Dukic S, McMackin R, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Costello E, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, Pender N, Bede P, Muthuraman M, Lalor EC, Hardiman O, Nasseroleslami B., Patterned functional network disruption in amyotrophic lateral sclerosis. , Human Brain Mapping, 40, (16), 2019, p4827 - 4842Journal Article, 2019, URL
McMackin R, Dukic S, Costello E, Pinto-Grau M, Fasano A, Buxo T, Heverin M, Reilly R, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B., Localization of Brain Networks Engaged by the Sustained Attention to Response Task Provides Quantitative Markers of Executive Impairment in Amyotrophic Lateral Sclerosis., Cerebral cortex (New York, N.Y. : 1991), 2020Journal Article, 2020, DOI
Calvert GHM, McMackin R, Carson RG., Probing interhemispheric dorsal premotor-primary motor cortex interactions with threshold hunting transcranial magnetic stimulation., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 131, (11), 2020, p2551-2560Journal Article, 2020, DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, Keenan O, Fasano A, Buxo T, Heverin M, Reilly RB, Pender N, Hardiman O, Nasseroleslami B, Sustained attention to response task-related beta oscillations relate to performance and provide a functional biomarker in ALS., Journal of neural engineering, 18, (2), 2021, p026006Journal Article, 2021, DOI
McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. , Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis., Neurobiol Aging, 104, 2021, p57-70Journal Article, 2021
Costello E, Rooney J, Pinto-Grau M, Burke T, Elamin M, Bede P, McMackin R, Dukic S, Vajda A, Heverin M, Hardiman O, Pender N. , Cognitive reserve in amyotrophic lateral sclerosis (ALS): a population-based longitudinal study. , J Neurol Neurosurg Psychiatry. , 92, (5), 2021, p460-465Journal Article, 2021, TARA - Full Text
Dukic S, McMackin R, Costello E, Metzger M, Buxo T, Fasano A, Chipika R, Pinto-Grau M, Schuster C, Hammond M, Heverin M, Coffey A, Broderick M, Iyer PM, Mohr K, Gavin B, McLaughlin R, Pender N, Bede P, Muthuraman M, van den Berg L, Hardiman O, Nasseroleslami B., Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis., Brain : a journal of neurology, (awab3222), 2021Journal Article, 2021, DOI

Dr McMackin"s research includes the use of electroencephalography (EEG) and transcranial magnetic stimulation (TMS) to investigate neural network function in health and neurodegenerative diseases. Her research aims are (i) to improve understanding of the cellular, neurochemical and and network physiology captured by electrophysiological measurements and (ii) to use electrophysiological measurements to progress understanding of neurodegenerative disease mechanisms, to identify diagnostic and prognostic biomarkers and to improve the outcome measures used to test potential therapies in neurological clinical trials. Dr McMackin has a particular interest in amyotrophic lateral sclerosis (ALS), the most common form of Motor Neurone Disease. Dr McMackin is also actively involved in preclinical drug development wet lab studies.

Medical, Health and Life Sciences & Technologies, Genetics and Genomics, Neuroscience and clinical neurology, Psychology and Behavioural Sciences, Pharmacology & Toxicology including drug formulation and delivery, Medical Engineering, Biotechnology and devices (including medical laboratory technologies and informatics),

Recognition

Barbara Ryan Prize (TCD) 2015
Trinity College Dublin Non-Foundation Scholarship 2014
Eli Lilly Chemistry Prize 2013
Neuroscience Ireland Early Career Investigator Award 2022
Julian Boldy Prize (TCD) 2013
Trinity College Dublin University Gold Medal 2016
Omniscient Neurotechnology Infinitome Imaging Award 2021
Brainbox Research Challenge Award 2020

Neuroscience Ireland Present
Irish Electrophysiology Research Clinic Present

Trinity College Dublin Representative of the Neuroscience Ireland Committee 14/08/2023