Professor Marina Annetta Lynch

• Lynch, MA, Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli., Journal of Alzheimers Disease, 44 , (3), 2015, p949-962Journal Article, 2015, TARA - Full Text
• Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 46, 2015, p70-79Journal Article, 2015, DOI , TARA - Full Text
• McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560Journal Article, 2015, DOI , URL
• Barrett J., Costello D., O'Sullivan J., Cowley T., Lynch M., Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli, Journal of Neuroinflammation, 12, (1), 2015, p67Journal Article, 2015, DOI , TARA - Full Text
• Barrett J., Minogue A., Falvey A., Lynch M., Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages, Experimental Cell Research, 335, (2), 2015, p258-268Journal Article, 2015, DOI
• Raasay S. Jones, Aedín M. Minogue, Orla Fitzpatrick, Marina A. Lynch, Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice, Experimental Cell Research, 36, (10), 2015, p2716-2724Journal Article, 2015, DOI , TARA - Full Text
• Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S, Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP., PloS one, 9, (9), 2014, pe106503Journal Article, 2014, DOI , TARA - Full Text
• Lynch, MA, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Current Opinion in Pharmacology, 26, 2015, p67 - 73Journal Article, 2015
• Karen Bryson and Marina Lynch, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Curr Opin Pharmacol. , 26,, 2015, 67-73.Review, 2015
• [DEPT. PHYSIOLOGY PUBLICATION] Campbell V.A. and Segurado R. and Lynch M. A., Regulation of intracellular Ca2+ concentration by interleukin-1beta in rat cortical synaptosomes: an age-related study, Neurobiology of Aging, 19, (6), 1998, p575 - 579Journal Article, 1998, URL
• Drechsler S, Lynch M.A, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro R.E, Vandenbroucke R.E, Osuchowski M, Potter P.K, With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions, Mechanisms of Ageing and Development, 160, 2016, p54 - 68Journal Article, 2016, DOI , URL
• Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 54, (7), 2017, p5730 - 5739Journal Article, 2017, DOI , URL
• McDonald C.L, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch M.A, Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease, Brain, Behavior, and Immunity, 58, 2016, p191 - 200Journal Article, 2016, DOI , URL
• Andreasson K.I, Bachstetter A.D, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee D.C, Low D, Lynch M.A, Monsonego A, O'Banion M.K, Pekny M, Puschmann T, Russek-Blum N, Sandusky L.A, Selenica M.-L.B, Takata K, Teeling J, Town T, Van Eldik L.J, Targeting innate immunity for neurodegenerative disorders of the central nervous system, Journal of Neurochemistry, 2016, p653 - 693Journal Article, 2016, DOI , URL
• Costello D.A, Keenan K, McManus R.M, Falvey A, Lynch M.A, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function, Neurobiology of Aging, 43, 2016, p140 - 148Journal Article, 2016, DOI , URL
• C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316Journal Article, 2017, TARA - Full Text
• McHugh Power, J.E., Carney, S., Hannigan, C., Brennan, S., Wolfe, H., Lynch, M., Kee, F. and Lawlor, B.A., Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort, Journal of Health Psychology, 2016Journal Article, 2016, URL
• Costello D.A, Carney D.G, Lynch M.A, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR, Brain, Behavior, and Immunity, 46, 2015, p70 - 79Journal Article, 2015, DOI , URL
• MARTIN, DSD, Lynch, MA, A DIET ENRICHED IN ALPHA-LIPOIC ACID REVERSES THE AGE-RELATED COMPROMISE IN ANTIOXIDANT DEFENCES IN RAT CORTICAL TISSUE, NUTRITIONAL NEUROSCIENCE, 3, 2000, p193 - 206Journal Article, 2000
• McGahon B, Lynch MA., A STUDY OF THE SYNERGISM BETWEEN METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION AND ARACHIDONIC-ACID IN THE RAT HIPPOCAMPUS, NEUROREPORT, 5, (17), 1994, p2353 - 2357Journal Article, 1994
• McGahon B, Maguire C, Kelly Á, Lynch MA., Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes., NEUROSCIENCE, 90, (4), 1999, p1167 - 1175Journal Article, 1999, DOI , URL
• Maguire C, Casey M, Kelly Á, Mullany PM. Lynch MA. , Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus, Hippocampus, 9, (5), 1999, p519 - 526Journal Article, 1999, URL
• LYNCH, MA, ADMINISTRATION OF LOW-DOSES OF TSH RESULT IN A RAPID INCREASE IN THE METABOLIC-RATE OF YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (3), 1985, p136 - 140Journal Article, 1985
• Bernadette M. McGahon, Donen S. D. Martin, David F. Horrobin and Marina A. Lynch, Age-related changes in LTP and antioxidant defenses are reversed by an á-lipoic acid-enriched diet, NEUROBIOLOGY OF AGING, 20, (6), 1999, p655 - 664Journal Article, 1999, DOI , URL
• B. M. McGahon, C. A. Murray, D. F. Horrobin and M. A. Lynch, Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, NEUROBIOLOGY OF AGING, 20, (6), 1999, p643 - 653Journal Article, 1999, DOI , URL
• McGahon BM, Martin DS, Horrobin DF, Lynch MA., Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids., NEUROSCIENCE, 94, (1), 1999, p305 - 314Journal Article, 1999, DOI , URL
• LYNCH, MA, AGE-RELATED CHANGES IN SYNAPTIC PLASTICITY IN RAT HIPPOCAMPUS, unknown, 1997, 501P, ISI Web of Science, 1997, ppS5 - S6Miscellaneous, 1997
• LYNCH, MA, AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN HIPPOCAMPUS: A ROLE FOR THE CYTOKINE, INTERLEUKIN-1 BETA?, PROGRESS IN NEUROBIOLOGY, 56, 1998Review, 1998, DOI , URL
• Eamonn O'Donnell, Emily Vereker, M. A. Lynch, Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms , EUROPEAN JOURNAL OF NEUROSCIENCE, 12, (1), 2000, p345 - 352Journal Article, 2000, DOI , URL
• Patricia Mullany, Shane Connolly and Marina A. Lynch, Ageing is associated with changes in glutamate release, protein tyrosine kinase and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus , EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p311 - 315Journal Article, 1996, DOI , URL
• MCGAHON, B, MURRAY, CA, CLEMENTS, MP, LYNCH, MA, ANALYSIS OF THE EFFECT OF MEMBRANE ARACHIDONIC ACID CONCENTRATION ON MODULATION OF GLUTAMATE RELEASE BY INTERLEUKIN-1: AN AGE-RELATED STUDY, EXPERIMENTAL GERONTOLOGY, 33, 1998, p343 - 354Journal Article, 1998
• MCGAHON, B, LYNCH, MA, ANALYSIS OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION REVEALS THAT PHOSPHOLIPASE C ACTS AS A COINCIDENCE DETECTOR IN THE EXPRESSION OF LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, HIPPOCAMPUS, 8, 1998, p48 - 56Journal Article, 1998
• LYNCH, MA, ANALYSIS OF THE MECHANISMS UNDERLYING THE AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN THE RAT, REVIEWS IN THE NEUROSCIENCES, 9, 1998, p169 - 201Review, 1998
• M. Casey, C. Maguire, Á. Kelly, M.A. Gooney, M.A. Lynch, ANALYSIS OF THE PRESYNAPTIC SIGNALING MECHANISMS UNDERLYING THE INHIBITION OF LTP IN RAT DENTATE GYRUS BY THE TYROSINE KINASE INHIBITOR, GENISTEIN, HIPPOCAMPUS, 12, (3), 2002, p377 - 385Journal Article, 2002, DOI , URL
• Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, and Marina A. Lynch, Apoptotic changes in the aged brain are triggered by interleukin-1 beta-induced activation of P38 and reversed by treatment with eicosapentaenoic acid, Journal of Biological Chemistry, 277, (37), 2002, p34239 - 34246Journal Article, 2002, DOI , URL
• Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch, Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's immune modulation therapy, Neuroimmunomodulation, 10, (1), 2002, p40 - 46Journal Article, 2002, DOI , URL
• Campbell, Veronica; Lynch, Marina A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1[beta] in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, NEUROREPORT, 9, (9), 1998, p1923 - 1927Journal Article, 1998, URL
• CAMPBELL, VA, BIPHASIC MODULATION OF [CA2+](1) BY INTERLEUKIN-1 BETA IN RAT CORTICAL SYNAPTOSOMES, unknown, 1998, 509P, ISI Web of Science, 1998, pp55P - 55PMiscellaneous, 1998
• P. Mullany and M. A. Lynch , CHANGES IN PROTEIN SYNTHESIS AND SYNTHESIS OF THE SYNAPTIC VESICLE PROTEIN, SYNAPTOPHYSIN, IN ENTORHINAL CORTEX FOLLOWING INDUCTION OF LONG-TERM POTENTIATION IN DENTATE GYRUS: AN AGE-RELATED STUDY IN THE RAT, NEUROPHARMACOLOGY, 36, (7), 1997, p973 - 980Journal Article, 1997, DOI , URL
• HAUSS-WEGRZYNIAK, B, CHRONIC BRAIN INFLAMMATION RESULTS IN CELL LOSS IN THE ENTORHINAL CORTEX AND IMPAIRED LTP IN PERFORANT PATH-GRANULE CELL SYNAPSES, EXPERIMENTAL NEUROLOGY, 176, 2002, p336 - 341Journal Article, 2002, DOI , URL
• Kelly Á, Maguire C, Lynch MA., Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus, Neuroscience, 95, (2), 2000, p359 - 365Journal Article, 2000, DOI , URL
• E. O'Donnell and M. A. Lynch, DIETARY ANTIOXIDANT SUPPLEMENTATION REVERSES AGE-RELATED NEURONAL CHANGES, NEUROBIOLOGY OF AGING, 19, (5), 1998, p461 - 467Journal Article, 1998, DOI , URL
• Ciara A. Murray and Marina A. Lynch , DIETARY SUPPLEMENTATION WITH VITAMIN E REVERSES THE AGE-RELATED DEFICIT IN LONG TERM POTENTIATION IN DENTATE GYRUS, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, (20), 1998, p12161 - 12168Journal Article, 1998, URL
• Mullany PM, Lynch MA., Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus., NEUROREPORT, 9, (11), 1998, p2489 - 2494Journal Article, 1998, URL
• KELLY, A, EVIDENCE INDICATING A ROLE FOR NERVE GROWTH FACTOR IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT, unknown, 1997, 501P, ISI Web of Science, 1997, ppP89 - P89Miscellaneous, 1997
• Murray, C A , Lynch, M A, Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1 Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation, JOURNAL OF NEUROSCIENCE, 18, (8), 1998, p2974 - 2981Journal Article, 1998, URL
• MCGAHON, B, EVIDENCE THAT LONG-TERM POTENTIATION IN RAT DENTATE GYRUS UTILIZES PHOSPHOLIPASE C AS A COINCIDENCE DETECTOR: INVESTIGATION OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND THE METABOTROPIC GLUTAMATE RECEPTOR AGONIST, 1-AMINO-CYCLOPENTANE-1,3-DICARBOXYLATE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP88 - P88Miscellaneous, 1997
• Kelly Á, Conroy S, Lynch MA., Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus., Neuropharmacology, 37, (4-5), 1998, p561 - 570Journal Article, 1998, DOI , URL
• Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina , Glycerol-induced seizure: Involvement of IL-1[beta] and glutamate, NEUROREPORT, 10, (9), 1999, p1821 - 1825Journal Article, 1999, URL
• MURRAY, CA, IMPAIRED ABILITY OF AGED RATS TO SUSTAIN LONG-TERM POTENTIATION MAY RESULT FROM INCREASED HIPPOCAMPAL EXPRESSION OF INTERLEUKIN-1 BETA, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P87Miscellaneous, 1997
• Lynch MA, Voss KL, Gower AJ., Impaired spatial memory in aged rats is associated with alterations in inositol phospholipid metabolism., NEUROREPORT, 5, (12), 1994, p1493 - 1497Journal Article, 1994
• MULLANY, P, INDUCTION OF LONG-TERM POTENTIATION IN VIVO IN RAT DENTATE GYRUS IS ACCOMPANIED BY AN INCREASE IN PHOSPHORYLATION OF RECEPTOR TYROSINE KINASE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P88Miscellaneous, 1997
• LYNCH, MA, INTERLEUKIN-1 BETA EXERTS A MYRIAD OF EFFECTS IN THE BRAIN AND IN PARTICULAR IN THE HIPPOCAMPUS: ANALYSIS OF SOME OF THESE ACTIONS, VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS, 64, 2002Review, 2002, DOI , URL
• Murray CA, McGahon B, McBennett S, Lynch MA., Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats., NEUROBIOLOGY OF AGING, 18, (3), 1997, p343 - 348Journal Article, 1997, DOI , URL
• Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, and Marina A. Lynch, Interleukin-1â-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine , Journal of Neuroimmunology, 111, (1-2), 2000, p68 - 76Journal Article, 2000, DOI , URL
• C.A. Murray, M.P. Clements & M.A. Lynch, Interleukin-1 Induces Lipid Peroxidation and Membrane Changes in Rat Hippocampus: An Age-Related Study, Gerontology, 45, 1999, p136 - 142Journal Article, 1999, URL
• CAMPBELL, V, INTRACEREBROVENTRICULAR ADMINISTRATION OF A CASPASE-1 INHIBITOR BLOCKS THE MODULATORY EFFECTS OF LIPOPOLYSACCHARIDE ON LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, unknown, 2000, 526, ISI Web of Science, 2000, pp59P - 59PMiscellaneous, 2000
• CAMPBELL, V, INTRAPERITONEAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES APOPTOSIS IN RAT ENTORHINAL CORTEX, unknown, 2000, 523, ISI Web of Science, 2000, pp189P - 189PMiscellaneous, 2000
• LYNCH, MA , LIPOIC ACID CONFERS PROTECTION AGAINST OXIDATIVE INJURY IN NON-NEURONAL AND NEURONAL TISSUE, NUTRITIONAL NEUROSCIENCE, 4, 2002Review, 2002
• Vereker E, Campbell V, Roche E, McEntee E, Lynch MA., Lipoplysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, Journal of Biological Chemistry, 275, (34), 2000, p26252 - 26258Journal Article, 2000, DOI , URL
• VEREKER, E, LIPOPOLYSACCHARIDE INHIBITS LONG-TERM POTENTIATION AND GLUTAMATE RELEASE IN RAT DENTATE GYRUS, unknown, 2000, 523, ISI Web of Science, 2000, pp188P - 189PMiscellaneous, 2000
• Martina Gooney, M. A. Lynch , LONG-TERM POTENTIATION IN AGED RATS IS RESTORED WHEN THE AGE-RELATED DECREASE IN POLYUNSATURATED FATTY ACID CONCENTRATION IS REVERSED, PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 67, (5), 2002, p121 - 130Journal Article, 2002, DOI , URL
• Martina Gooney, M. A. Lynch, LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS IS ACCOMPANIED BY BRAIN-DERIVED NEUROTROPHIC FACTOR-INDUCED ACTIVATION OF TRKB, JOURNAL OF NEUROCHEMISTRY, 77, (5), 2001, p1198 - 1207Journal Article, 2001, DOI , URL
• LYNCH, MA, LOW-DOSES OF T3 INDUCE A RAPID METABOLIC RESPONSE IN YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (2), 1985, p63 - 66Journal Article, 1985
• Lynch MA, Voss KL., Membrane Arachidonic Acid Concentration Correlates with Age and Induction of Long-term Potentiation in the Dentate Gyrus in the Rat, EUROPEAN JOURNAL OF NEUROSCIENCE, 6, (6), 1994, p1008 - 1014Journal Article, 1994, DOI , URL
• Elizabeth Whittaker, Emily Vereker and M. A. Lynch, Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus , Brain Research , 827, 1999, p229 - 233Journal Article, 1999, DOI , URL
• MURPHY, KJ, NEUROPLASTIC EVENTS REQUIRED-FOR LTP AND AVOIDANCE LEARNING ARE IMPAIRED BY OPIATE ADDICTION, unknown, 2001, 134, ISI Web of Science, 2002, ppU80 - U80Miscellaneous, 2002
• Peter E. Lonergan, Darren S. D. Martin, David F. Horrobin, and Marina A. Lynch, NEUROPROTECTIVE EFFECT OF EICOSAPENTAENOIC ACID IN HIPPOCAMPUS OF RATS EXPOSED TO GAMMA-IRRADIATION, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, (23), 2002, p20804 - 20811Journal Article, 2002, DOI , URL
• MURPHY, KJ, OPIATE ADDICTION IMPAIRS NEUROPLASTIC EVENTS ASSOCIATED WITH MEMORY FORMATION, unknown, 2000, 12, ISI Web of Science, 2000, pp206 - 206Miscellaneous, 2000
• DHANRAJAN, TM, PLASTICITY OF DENDRITIC SPINES IN HIPPOCAMPUS OF YOUNG AND AGED RATS 45 MIN AFTER LTP INDUCTION., unknown, 1998, 10, ISI Web of Science, 1998, pp391 - 391Miscellaneous, 1998
• Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH., Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine., Annals of the New York Academy of Sciences, 856, 1998, p274 - 277Journal Article, 1998, URL
• V. A. Campbell, R. Segurado and M. A. Lynch, Regulation of intracellular Ca2+ concentration by interleukin-1â in rat cortical synaptosomes: an age-related study , Neurobiology of Aging, 19, (6), 1998, p575 - 579Journal Article, 1998, DOI , URL
• SHAW, K, STRESS: HOW IT AFFECTS SPATIAL LEARNING AND BDNF EXPRESSION, unknown, 2000, 12, ISI Web of Science, 2000, pp330 - 330Miscellaneous, 2000
• McGahon B, Clements MP, Lynch MA., The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed., NEUROSCIENCE, 81, (1), 1997, p9 - 16Journal Article, 1997, DOI , URL
• Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788Journal Article, 2002, DOI , URL
• Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572Journal Article, 2001, DOI , TARA - Full Text
• OMARA, SM, THE EFFECTS OF THE ENDOTOXIN LIPOPOLYSACCHARIDE ON SYNAPTIC TRANSMISSION AND PLASTICITY IN THE CA1-SUBICULUM PATHWAY IN VIVO, unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250Miscellaneous, 2000
• E. Vereker, E. O'Donnell, and M. A. Lynch, The Inhibitory Effect of Interleukin-1b on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases, JOURNAL OF NEUROSCIENCE, 20, (18), 2000, p6811 - 6819Journal Article, 2000, URL
• M. A. Lynch, J. D. Bruton, J. F. Andrews and R. E. Moore , THE RAPID METABOLIC RESPONSE OF YOUNG LAMBS TO LOW-DOSES OF T3 - INTERACTION WITH RT3, JOURNAL OF THERMAL BIOLOGY, 10, (2), 1985, p71 - 77Journal Article, 1985, DOI , URL
• Veronica Campbell and Marina A. Lynch , The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1beta in rat cortical synaptosomes, Cytokine, 12, (5), 2000, p487 - 490Journal Article, 2000, DOI , URL
• LYNCH, MA, THE ROLE OF STRESS-ACTIVATED PROTEIN KINASES IN THE INHIBITION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS INDUCED BY IL-1, unknown, 2001, 77, ISI Web of Science, 2001, pp18 - 18Miscellaneous, 2001
• McGahon B, Lynch MA., THE SYNERGISM BETWEEN ACPD AND ARACHIDONIC ACID ON GLUTAMATE RELEASE IN HIPPOCAMPUS IS AGE-DEPENDENT, EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p323 - 326Journal Article, 1996, DOI , URL
• MCGAHON, B, THE SYNERGISM BETWEEN ARACHIDONIC-ACID AND ACPD ON GLUTAMATE RELEASE IN DENTATE GYRUS IS OCCLUDED BY INDUCTION OF LONG-TERM POTENTIATION, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P7Miscellaneous, 1995
• B. McGahon and M. A. Lynch, The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus , NEUROSCIENCE, 72, (3), 1996, p847 - 855Journal Article, 1996, DOI , URL
• McGahon B, Holscher C, McGlinchey L, Rowan MJ, Lynch MA., Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus., Learning and Memory, 3, (4), 1997, p296 - 304Journal Article, 1997, DOI , URL
• LYNCH, MA, WHAT IS THE BIOLOGICAL SIGNIFICANCE OF AN AGE-RELATED INCREASE IN IL-1 BETA IN HIPPOCAMPUS?, MOLECULAR PSYCHIATRY, 4, 1999, 15 - 18Miscellaneous, 1999
• Sheila Donnelly, Christine E. Loscher, Marina A. Lynch, and Kingston H. G. Mills, Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination, Infection and Immunity, 69, (7), 2001, p4217 - 4223Journal Article, 2001, DOI , TARA - Full Text
• Gooney M, Shaw K, Kelly Á, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA., Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor., Behavioural Neuroscience, 116, (3), 2002, p455 - 463Journal Article, 2002, URL
• Kelly Á, Mullany PM, Lynch MA., Protein synthesis in entorhinal cortex and long-term potentiation in dentate gyrus., Hippocampus, 10, (49), 2000, p431 - 437Journal Article, 2000, DOI , URL
• Kelly Á, Lynch MA., Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin, Neuropharmacology, 39, (49), 2000, p643 - 651Journal Article, 2000, DOI
• Kelly Á, Lynch MA., LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD, Neuroreport, 9, (18), 1998, p4087 - 4091Journal Article, 1998, URL
• McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12Journal Article, 2017, DOI
• Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243Journal Article, 2017, DOI
• McHugh Power, J.E., Carney, S., Hannigan, C., Brennan, S., Wolfe, H., Lynch, M., Kee, F. and Lawlor, B.A., , Systemic inflammatory markers and sources of social support among older adults in the Memory Research Unit cohort, Journal of Health Psychology, 2016Journal Article, 2016, URL
• Bryson KJ, Lynch MA, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair., Current opinion in pharmacology, 26, 2015, p67-73Journal Article, 2015, DOI
• Costello DA, Keenan K, McManus RM, Falvey A, Lynch MA, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function., Neurobiology of aging, 43, 2016, p140-8Journal Article, 2016, DOI
• Holland, R. and McIntosh, A.L. and Finucane, O.M. and Mela, V. and Rubio-Araiz, A. and Timmons, G. and McCarthy, S.A. and Gun'ko, Y.K. and Lynch, M.A., Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice, Brain, Behavior, and Immunity, 2018, p183-196-Journal Article, 2018, DOI , URL
• Wolfe H, Hannigan C, O'Sulivan M, Carrol, LB, Brennan S, Lawlor, R, Robertson, IH, Lynch, M, A shift to glycolysis accompanies the inflammatory changes in PBMCs from Individuals with an IQ-discrepant memory, Journal of Neuroimmunology, 317, 2018, p24 - 31Journal Article, 2018, URL
• Wolfe, H. and Minogue, A.M. and Rooney, S. and Lynch, M.A., Infiltrating macrophages contribute to age-related neuroinflammation in C57/BL6 mice, Mechanisms of Ageing and Development, 173, 2018, p84-91Journal Article, 2018, DOI , URL
• Rubio-Araiz, A. and Finucane, O.M. and Keogh, S. and Lynch, M.A., Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of β-amyloid, Journal of Neuroinflammation, 15, (1), 2018, p247-Journal Article, 2018, DOI , URL , TARA - Full Text
• McIntosh A, Mela V, Harty C, Minogue AM, Costello DA, Kerskens C, Lynch MA., Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice., Brain Pathology, 2019, p10.1111/bpa.12704.Journal Article, 2019, DOI , TARA - Full Text
• Wolfe H, Rivas VM, Minogue AM, Miller AM, McGuigan C, Williams L, Lohan D, Lawlor BA, Lynch MA., Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming., Neuroscience Research, 2019, p1-Journal Article, 2019, DOI , TARA - Full Text
• LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in the catecholamine content in 4 regions of the rat brain following acute ampetamine treatment: antagonistic effect of chlorpromazine, I.C.R.S. Med.Sci., 5, 1977, p561Journal Article, 1977
• LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in behaviour in rats in the "open field" apparatus after chronic amphetamine administration: acute effects of 3 antidepressants, I.C.R.S. Med. Sci., 5, 1977, pp.571Journal Article, 1977
• LYNCH, M., KENNY, M. and LEONARD, B.E., The effect of chronic administration of D-amphetamine on regional changes in catecholamines in the rat brain., Journal of Neuroscience Research, 3, 1977, p.295Journal Article, 1977
• Finucane O.M, Sugrue J, Rubio-Araiz A, Guillot-Sestier M.-V, Lynch M.A, The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1β-dependent manner in macrophages, Scientific Reports, 9, (1), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• LYNCH, M. and LEONARD, B.E., Changes in brain gamma aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression., Biochemical Pharmocology, 27, (14), 1978, p1853-1855Journal Article, 1978
• LYNCH, M., KENNY, M. and LEONARD, B.E., Effect of D-amphetamine on the behaviour of rats in the "open field": interaction with 4 neuroleptics and changes in biogenic amine metabolism in discrete brain regions., Irish Journal of Medical Science, 147, (10), 1978, p337-350Journal Article, 1978
• LYNCH, M. and LEONARD, B.E., Effect of chronic amphetamine administration on the behaviour of rats in the "open field" apparatus: reversal of post-withdrawl depression by 2 antidepressants, J Pharm Pharmacol. , 30, (12), 1978, p798-799Journal Article, 1978
• KENNY, M., LYNCH, M. and LEONARD, B.E., Induction of two distinct behavioural responses by chronic treatment with apomorphine, Journal of Neuroscience Research, 5, (1), 1980, p35-42Journal Article, 1980
• FENN, G.C., LYNCH, M., NHAMBURO, P.T., CABEROS, L.P. and LITTLETON, J.M., A comparison of effects of ethanol on platelet function and synaptic trasmission, Pharmacology, Biochemisty and Behaviour, 18, Supplement 1., 1983, p37-43Journal Article, 1983
• SAMUEL, D., LYNCH, M. and LITTLETON, J.M., Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum, Neuropharmacology, 22, (12), 1983, p1413-1415Journal Article, 1983, DOI , URL
• Mela, V. and Mota, B.C. and Milner, M. and McGinley, A. and Mills, K.H.G. and Kelly, Ã .M. and Lynch, M.A., Exercise-induced re-programming of age-related metabolic changes in microglia is accompanied by a reduction in senescent cells, Brain, Behavior, and Immunity, 87, 2020, p413-428Journal Article, 2020, DOI , URL
• Caberos, L.P., Lynch, M., Leroy, C., Fenn, G.C. and Littleton J.M., Interaction of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices, Biochem. Pharmacol., 32, (14), 1983, p2211-2216Journal Article, 1983, DOI , URL
• Lynch, M., Littleton, J.M., McKernan, R.M., Durcan, M.J., McMillan, J. and Campbell, I.C., Alpha-adrenoceptor number and function in rat cortex after ethanol and immobilization stress, Brain . Res., 288, (1-2), 1983, p145 - 149Journal Article, 1983, DOI , URL
• Lynch, M. and Littleton, J.M.,, Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity, Nature, 303, 1983, p175 - 177Journal Article, 1983, DOI , URL
• Lynch, M.A. and Voss, K.L., Presynaptic changes in long-term potentiation: elevated synaptosomal calcium concentration and basal phosphoinositide turnover in dentate gyrus, J. Neurochem., 56, (1), 1991, p113 - 118Journal Article, 1991, DOI , URL
• Jeffreys, J.G.R., Mitchell, P., O'Hara, L., Tiley, C., Hardy, J., Jordan, S.J., Lynch, M.A. and Wandsworth, J., Ex vivo release of GABA from tetanus toxin induced chronic epileptic foci decreased during active seizure phase, Neurochem. Int., Int., (18), 1991, p373 - 379Journal Article, 1991, DOI , URL
• Lynch, M.A., Clements, M.P., Voss, K.L., Bramham, C.R. and Bliss, T.V.P., Is arachidonic acid a retrograde messanger inlong-term potentiation?, Biochem. Soc. Trans., 19, 1991, p391 - 386Journal Article, 1991
• Clements, M.P., Bliss, T.V.P. and Lynch, M.A., Increase in arachidonic acid concentration in a postsynaptic density fraction following the induction of long-term potentiation in the dentate gyrus, Neuroscience, 45, (2), 1991, p379 - 389Journal Article, 1991, DOI , URL
• Williams, J.H., Errington, M.L., Li, Y-G., Lynch, M.A. and Bliss, T.V.P., The search for retrograde messangers in long-term potentiation, Seminars in the neurosciences, 5, 1993, p149 - 158Journal Article, 1993
• Lynch, M.A., Jaques-Berg, W., Lawson, P.R., Voss, K.L. and Bliss, T.V.P., The effect of arachidonic acid on uptake in cortical and hippocampal preparations, Neurosci. Res. Comm., 14, 1994, p53 - 61Journal Article, 1994
• Lynch, M.A., Voss, K.L., Rodriguez, J. and Bliss, T.V.P., Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus, Neuroscience, 60, (1), 1994, p1 - 5Journal Article, 1994, DOI , URL
• Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20Journal Article, 1996, DOI , URL
• Murray, C. and Lynch, M.A., Analysis of the mechanism by which dietary supplementation with vitamin E and vitamin C restores ability of aged animals to sustain long-term potentiation in dentate gyrus, J. Biol. Chem., 273, (20), 1998, p12161 - 12168Journal Article, 1998, DOI , URL
• McGahon, B.M., Murray, C.A., Horrobin, D.F. and Lynch, M.A., Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, Neurobiol. Aging, 20, (6), 1999, p643 - 653Journal Article, 1999, DOI , URL
• Lynch, M.A., Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue, Nut. Neurosci, 4, 2001, p419 - 438Review, 2001
• Lynch, M.A., IL-1beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions, Vitamins and Hormones, 64, 2002, p185 - 219Journal Article, 2002, DOI , URL
• Kelly Á, Vereker E, Brady M. Barry C, Loscher C, Mills KHG, Lynch MA., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462Journal Article, 2003, DOI , URL , TARA - Full Text
• Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124Journal Article, 2003, DOI , URL
• Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33Journal Article, 2003, DOI , URL
• Dhanrajan TM, Lynch MA, Kelly Á, Popov VI, Rusakov DA , Stewart MG., Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high frequency stimulation alone, Hippocampus, 14, (2), 2004, p255 - 264Journal Article, 2004, DOI , URL
• Minogue, A.M., Schmid, A.W., Fogarty, M.F., Moore, A.C., Campbell, V.A. and Herron, C.E., Activation of the JNK signalling cascade mediates the effect of A beta on LTP and cell death in hippocampus: a role for IL-1 beta, J. Biol. Chem., 278, (30), 2003, p27971 - 27980Journal Article, 2003, DOI , URL
• Lynch, M.A., Long-Term Potentiation and memory, Physiol. Rev., 84, 2004, p87 - 136Journal Article, 2004, DOI
• Lynch, M.A., Can the emerging field of immunometabolism provide insights into neuroinflammation?, Progress in Neurobiology, 184, (101719), 2020Journal Article, 2020, DOI , URL
• Davies HA, Kelly Á, Dhanrajan TM, Lynch MA, Rodriguez JJ, Stewart MG., Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats, Brain Res., 986, ((1-2):), 2003, p191 - 195Journal Article, 2003, DOI , URL
• Lynch, A.M., Moore, M., Craig, S. Lonergan, P.E., Martin, D.S., Lynch, M.A., Analysis of IL-1beta -induced cell signalling activation in rat hippocampus following exposure to gamma irradiation: protective effect of eicosapentaenoic acid, J. Biol. Chem., 278, (51), 2003, p51075 - 51084Journal Article, 2003, DOI , URL
• Nolan, Y., Vereker, E., Lynch, A.M., and Lynch, M.A., Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygene species and activation of p38 in rat cortex and hippocampus, Exp. Neurol., 184, (2), 2003, p794 - 804Journal Article, 2003, DOI , URL
• Maher, F.O. and Lynch, M.A., Age-related downregulation in neurotrophin-induced signaling and upregulation of interleukin-1 beta-induced signaling combine to decrease synaptic function in rat cortex, Neurobiol. Aging, 2003, p794 - 804Journal Article, 2003
• Nolan, Y., Martin, D.S.D., Campbell, V.A., and Lynch, M.A., Evidence of a protective effect of phosphatidylserine on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus, J. Neuroimmunol., 151, (Issues 1-2,), 2004, p12-23Journal Article, 2004, DOI , URL
• Gooney, M., Messaoudi, E., Maher, F.O., Bramham, C.R. and Lynch, M.A., BDNF-induced LTP is associated with enhanced release of endogenous BDNF and glutamate and presynaptic activation of CREB: analysis of deficits in aged rats, Neurobiol. Aging, 25, (10), 2004, p1323-1331Journal Article, 2004, DOI , URL
• Kavanagh, T., Lonergan, P.E. and Lynch, M.A., Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation, Prostaglandins Leukot. Essent. Fatty Acids, 70, 2004, p391 - 397Journal Article, 2004, DOI , URL
• Lynch, M.A. and Littleton, J.M., Enhanced (3)H noradrenaline release in synaptosomes from ethanol-tolerant animals: the role of nerve terminal Ca(2+), Alcohol and Alcoholism, 20, 1985, p5 - 11Journal Article, 1985, URL
• Lynch, M., Pagonis, C., Samuel, D. and Littleton, J.M., Alterations in Ca(2+) - dependent and Ca(2+) independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo, Alcohol, 2, (1), 1985, p139 - 144Journal Article, 1985, DOI , URL
• Feasey, K.J., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation is associated with an increase in calcium-dependent, potassium-stimulated release of (14)C glutamate from hippocampla slices: an ex vivo study in the rat, Brain Res., 364, 1985, p39 - 44Journal Article, 1985, DOI , URL
• Bliss, T.V.P., Douglas, R.M., Errington, M.L. and Lynch, M., Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats, J. Physiol., 377, 1986, p391 - 408Journal Article, 1986, URL
• Lynch, M. and Bliss, T.V.P., Noradrenaline modulates release of (14)C glutamate from dentate but not from CAI/CA3 slices of rat hippocampus, Neuropharmacology, 25, (5), 1986, p493 - 498Journal Article, 1986, DOI , URL
• Lynch, M., Errington, M.L. and Bliss, T.V.P., Long-term potentiation of synaptic transmission in dentate gyrus increased of (14)C glutamate without an increase in receptor binding, Neurosci. Letts., 65, (1), 1986, p123 - 129Journal Article, 1986, DOI , URL
• Lynch, M. and Bliss, T.V.P., On the mechanism of enhanced release on (14)C glutamate in hippocampal long-term potentiation, Brian Res., 369, (1-2), 1986, p405-408Journal Article, 1986, DOI , URL
• Lynch, M., Archer, E.R.and Littleton, J.M., Increased sensitivity of transmitter release to calcium in ethanol tolerance, Biochem. Pharmacol., 35, (7), 1986, p1207 - 1209Journal Article, 1986, DOI , URL
• Spencer, P., Lynch, M. and Bliss, T.V.P., In vitro release of (14)C glutamate from dentate gyrus in modulated by GABA, J. Pharm. Pharmacol., 38, (5), 1986, p393 - 395Journal Article, 1986
• Lynch, M.A.and Bliss, T.V.P., Long-term potentiation of synaptic transmission in CA3: effect of calmodulin and OAG on release of (3)H glutamate, Neurosci. Letts., 65, (2), 1986, p171 - 176Journal Article, 1986, DOI , URL
• Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)amino-phosphonovalerate, Neuroscience, 20, (1), 1987, p279 - 284Journal Article, 1987, DOI , URL
• Bliss, T.V.P., Errington, M.L., Laroche, S. and Lynch, M.A., Increase in K+-stimulated, Ca2+-dependent release of [3H]glutamate from rat dentate gyrus three days after induction of long-term potentiation, Neurosci. Letts., 83, (1-2), 1987, p107 - 112Journal Article, 1987, DOI , URL
• Laroche, S., Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Increase in (3)H glutamate release from slices of dentate gyrus and hippocampus following classical conditioning in the rat, Behavioural Brain Res., 25, (1), 1987, p23 - 29Journal Article, 1987, DOI , URL
• Lynch, M.A., Clements, M.P., Errington, M.L. and Bliss, T.V.P., Increased hydrolysis of phosphatidylinositol-4,5-bisphosphate in long-term potentiation , Neurosci. Letts., 84, (3), 1988, p291 - 296Journal Article, 1988, DOI , URL
• Clements, M.P., Lynch, M.A. and Bliss, T.V.P., The increase in phosphoinositide turnover associated with long-term potentiation may be mediated through a GTP binding protein, Neuroscience Research Communnications, 3, 1988, p11 - 19Journal Article, 1988
• Lynch, M.A., Errington, M.L. and Bliss, T.V.P., Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat., Neuroscience, 30, (3), 1989, p693 - 701Journal Article, 1989, DOI , URL
• Lynch, M.A.., Errington, M.L. and Bliss, T.V.P., The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation, Neuroscience Letters, 103, (3), 1989, p191 - 197Journal Article, 1989, DOI , URL
• Laroche, R., Redini-Del Negro, C., Clements, M.P., and Lynch, M.A., Long-term activation of phosphoinositide turnover associated with increased release of amino acides in the dentate gyrus and the hippocampus following classical conditioning in the rat., European J. Neurosci., 2, (6), 1990, p534 - 543Journal Article, 1990, DOI , URL
• Bliss, T.V., Errington, M.L., Lynch, M.A., Long-term potentiation in the dentate gyrus in vivo is associated with a sustained increase in extracellular glutamate, Adv. Exp. Med. Biol., 268, 1990, p269 - 278Journal Article, 1990
• Lynch, M.A., Mechanisms underlying induction and maintenance of long-term potentiation in the hippocampus, Bioessays, 10, (2-3), 1989, p85 - 90Journal Article, 1989, DOI , URL
• Lynch, M.A., Errington, M.L., Celements, M.P., Bliss, T.V.P., Redini Del Negro, C. and Laroche, S., Increases in glutamate and phosphoinositide metabolism associated with long-term potentiation and classical conditioning, Progr. Brain Res., 83, 1990, p251 - 256Journal Article, 1990
• Williams, J.H., Errington, M.L., Lynch, M.A. and Bliss, T.V.P., Arachidonic acid induces a long-term, activity-dependent enhancement of synaptic transmission in the hippocampus, Nature, 341, (6244), 1989, p739 - 742Journal Article, 1989, DOI , URL
• Lynch, M.A. and Voss, K.L., Arachidonic acid increases inositol phospholipid metabolims and glutamate release in synaptosomes prepared from hippocampal tissue, J. Neurochem., 55, (1), 1990, p215 - 221Journal Article, 1990, DOI , URL
• Clements, M.P., Errington, M.L., Bliss, T.V.P. and Lynch, M.A., Time-related changes in basal phosphoinositide turnover after induction of long-term potentiation in the dentate gyrus are blocked by commissural stimulation, Eur. J. Neurosci., 2, (4), 1990, p383 - 387Journal Article, 1990, DOI , URL
• Bliss, T.V.P., Clements, M.P., Errington, M.L., Lynch, M.A. and Williams, J.H., Presynaptic changes associated with long-term potentiation in the dentate gyrus, Semin. Neurosci., 2, 1990Journal Article, 1990
• Guillot-Sestier MV, Araiz AR, Mela V, Gaban AS, O'Neill E, Joshi L, Chouchani ET, Mills EL, Lynch MA., Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer's disease., Commun Biol, 4, (1), 2021, p711Journal Article, 2021, DOI
• Lynch, M.A., Exploring Sex-Related Differences in Microglia May Be a Game-Changer in Precision Medicine, Frontiers in Aging Neuroscience, 14, (868448), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Mela, V. and Gaban, A.S. and O†neill, E. and Bechet, S. and Walsh, A. and Lynch, M.A., The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific, Cells, 11, (4), 2022Journal Article, 2022, DOI , URL
• Paolicelli, R.C. and Sierra, A. and Stevens, B. and Tremblay, M.-E. and Aguzzi, A. and Ajami, B. and Amit, I. and Audinat, E. and Bechmann, I. and Bennett, M. and Bennett, F. and Bessis, A. and Biber, K. and Bilbo, S. and Blurton-Jones, M. and Boddeke, E. and Brites, D. and BrÃŽne, B. and Brown, G.C. and Butovsky, O. and Carson, M.J. and Castellano, B. and Colonna, M. and Cowley, S.A. and Cunningham, C. and Davalos, D. and De Jager, P.L. and de Strooper, B. and Denes, A. and Eggen, B.J.L. and Eyo, U. and Galea, E. and Garel, S. and Ginhoux, F. and Glass, C.K. and Gokce, O. and Gomez-Nicola, D. and González, B. and Gordon, S. and Graeber, M.B. and Greenhalgh, A.D. and Gressens, P. and Greter, M. and Gutmann, D.H. and Haass, C. and Heneka, M.T. and Heppner, F.L. and Hong, S. and Hume, D.A. and Jung, S. and Kettenmann, H. and Kipnis, J. and Koyama, R. and Lemke, G. and Lynch, M. and Majewska, A. and Malcangio, M. and Malm, T. and Mancuso, R. and Masuda, T. and Matteoli, M. and McColl, B.W. and Miron, V.E. and Molofsky, A.V. and Monje, M. and Mracsko, E. and Nadjar, A. and Neher, J.J. and Neniskyte, U. and Neumann, H. and Noda, M. and Peng, B. and Peri, F. and Perry, V.H. and Popovich, P.G. and Pridans, C. and Priller, J. and Prinz, M. and Ragozzino, D. and Ransohoff, R.M. and Salter, M.W. and Schaefer, A. and Schafer, D.P. and Schwartz, M. and Simons, M. and Smith, C.J. and Streit, W.J. and Tay, T.L. and Tsai, L.-H. and Verkhratsky, A. and von Bernhardi, R. and Wake, H. and Wittamer, V. and Wolf, S.A. and Wu, L.-J. and Wyss-Coray, T., Microglia states and nomenclature: A field at its crossroads, Neuron, 110, (21), 2022, p3458-3483Journal Article, 2022, DOI , URL
• Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KHG, Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines, Journal of Infectious Diseases, 192, (9), 2005, p1628 - 1633Journal Article, 2005, DOI , URL , TARA - Full Text
• Moore ME, Piazza A, McCartney Y, Lynch MA, Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus, Biochemical Society Transactions, 33, (4), 2005, p1628 - 1633Journal Article, 2005, URL
• Nolan Y, Campbell VA, Bolton AE, Lynch MA, Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy, Neuroimmunomodulation, 12, (2), 2005, p113 - 116Journal Article, 2005, DOI , URL
• Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231Journal Article, 2005, DOI , URL
• Maher FO, Nolan Y, Lynch MA, Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat., Neurobiology of Aging, 26, (5), 2005, p717 - 728Journal Article, 2005, DOI , URL
• Nolan Y, Maher FO, Clarke RM, Brady MT, Bolton AE, Mills KHG, Lynch MA, Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus., Journal of Biological Chemistry, 280, (10), 2005, p9354 - 9362Journal Article, 2005, DOI
• Lonergan PE, Martin DS, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29Journal Article, 2004
• Maher FO, Martin DS, Lynch MA, Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase., Neurobiology of Aging, 25, (6), 2004, p705 - 806Journal Article, 2004, DOI , URL
• Campbell, V. and Lynch, M.A , The role of ceramide in the interleukin-1ß-mediated modulation of [Ca2+]i in rat cortical synaptosomes., Cytokine, 12, (5), 2000, p487 - 490Journal Article, 2000, DOI
• Campbell, V. and Lynch, M.A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1ß in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, Neuroreport , 9, (9), 1998, p1923 - 1927Journal Article, 1998, URL
• Maher FO, Clarke RM, Kelly A, Nally RE, Lynch MA, Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation , JOURNAL OF NEUROCHEMISTRY , 96, 6, (MAR), 2006, p1560 - 1571Journal Article, 2006, DOI , URL
• Lynch MA, Inflammatory changes in regulation of hippocampal synaptic plasticity in the aged hippocampus , JOURNAL OF NEUROCHEMISTRY , 94, Suppl. 2, (Aug), 2005, pp11Meeting Abstract, 2005
• Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA , Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646Journal Article, 2004, DOI , URL
• Dietrich WD, Pearse DD, Lo TP, Cho KS, Lynch MA, Gorg MS, Marcillo AE, Sanchez AR, Bunge MB, Experimental graded cervical contusion in rats using spinal cord displacement: Pathology and behavioral recovery, JOURNAL OF NEUROTRAUMA , 21, (9), 2004, p1346Journal Article, 2004
• Lynch MA, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'connell F, Lynch MA, Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus, Neurobiol Aging, (May 19), 2006Journal Article, 2006, DOI , URL
• Lyons A., Griffin R, Costelloe C, Clarke RM and Lynch MA , IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro, Journal of Neurochemistry, 101, (3), 2007, p771-781Journal Article, 2007, DOI , URL
• Clarke RM, O'Connell, F. Lyons A and Lynch MA , The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. , Neuropharmacology , 52 , 2007, p136 - 145Journal Article, 2007, DOI , URL
• Griffin R, Nally R, Nolan Y, McCartney Y, Linden J and Lynch MA , The age-related attenuation in LTP is associated with microglial activation, Journal of Neurochemistry, 99, (44), 2007, p1263 - 1272Journal Article, 2007, DOI , URL
• Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313Journal Article, 2007, DOI , TARA - Full Text
• Moore M, Piazza A, Nolan Y, Lynch MA., Treatment with dexamethasone and vitamin D(3) attenuates neuroinflammatory age-related changes in rat hippocampus., Synapse, 61, (10), 2007, p851-61Journal Article, 2007, DOI , URL
• Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA., Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid., Journal of Neurochemistry, 2007Journal Article, 2007, DOI , URL
• Lynch, Marina A , The risky business of ageing. , Brain Behav Immun, 22, 2008, p299 - 300Journal Article, 2008, DOI , URL
• Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina, GLYCEROL-INDUCED SEIZURE: INVOLVEMENT OF IL-1 BETA AND GLUTAMATE, NEUROREPORT, 10, (9), 1999, p1821 - 1825Journal Article, 1999, URL
• Christine E. Loscher, Sheila Donnelly, Marina A. Lynch Kingston H. G. Mills, Induction of inflammatory cytokines in the brain following respiratory infection with bordetella pertussis, Journal of Neuroimmunology, 102, (2), 2000, p172 - 181Journal Article, 2000, DOI , URL
• Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, Marina A. Lynch, INTERLEUKIN-1 BETA-DEPENDENT CHANGES IN THE HIPPOCAMPUS FOLLOWING PARENTERAL IMMUNIZATION WITH A WHOLE CELL PERTUSSIS VACCINE, JOURNAL OF NEUROIMMUNOLOGY, 111, 2000, p68 - 76Journal Article, 2000, DOI , URL
• Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20Journal Article, 1996, DOI , URL
• Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA., Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiology of Aging, 30 , (6), 2009, p920 - 931Journal Article, 2009, DOI
• Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969Journal Article, 2008, DOI , URL
• Popov VI, Medvedev NI, Kraev IV, Gabbott PL, Davies H, Lynch MA, Cowley T,, A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study, Eur J Neurosci, 27, (2), 2008, p301-314Journal Article, 2008, DOI , URL
• Clarke RM, Lyons A, O'Connell F, Deighan BF, Barry CE, Anyakoha NG, Nicolaou A, Lynch MA, A pivotal role for IL-4 in atorvastatin-associated, J Biol Chem., 283, (4), 2008, p1808-1817Journal Article, 2008, DOI , URL
• Loane DJ, Deighan, BF, Clarke RM, Lynch AM, Lynch MA, Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiol Aging., 2007Journal Article, 2007, DOI , URL
• Little SJ, Lynch MA, Manku M and Nicolaou A, Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: A lipidomic analysis., Prostaglandins Leukot Essent Fatty Acids, 77, (3-4), 2007, p155-162Journal Article, 2007, DOI , URL
• Vereker, Emily and O'Donnell, Eamonn and Lynch, Ailenn and Nolan, Yvonne and Lynch, Marina A., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus, European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819Journal Article, 2001, DOI , URL
• Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128Journal Article, 2010, DOI , URL
• Corr, S.A., Byrne, S.J., Tekoriute, R., Meledandri, C.J., Brougham, D.F., Lynch, M., Kerskens, C, O'Dwyer, L, Gun'ko, Y.K. , Linear assemblies of magnetic nanoparticles as MRI contrast agents , Journal of the American Chemical Society , 130, (13), 2008, p4214-4215Journal Article, 2008, DOI , URL
• Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027Journal Article, 2009, DOI
• Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of Neurochemistry, 110, (5), 2009, p1547 - 1556Journal Article, 2009, DOI , URL , TARA - Full Text
• Gallagher, JJ, Tekoriute, R, O'Reilly, JA, Kerskens, C, Gun'ko, YK, Lynch, M, Bimodal magnetic-fluorescent nanostructures for biomedical applications, Journal of Materials Chemistry, 19, 2009, p4081 - 4084Journal Article, 2009, DOI , URL , TARA - Full Text
• Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607Journal Article, 2010, DOI , URL , TARA - Full Text
• Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607Journal Article, 2010, DOI , URL , TARA - Full Text
• Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995Journal Article, 2009, DOI
• Lonergan PE, Martin DSD, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29Journal Article, 2004, DOI , URL , TARA - Full Text
• Watson, M.B., Costello, D.A., Carney, D.G., McQuillan, K., Lynch, M.A., SIGIRR modulates the inflammatory response in the brain , Brain, Behavior, and Immunity, 24, (6), 2010, p985-995Journal Article, 2010, DOI , URL , TARA - Full Text
• Kelly, L. , Grehan, B. , Chiesa, A.D. , O'Mara, S.M. , Downer, E. , Sahyoun, G. , Massey, K.A. , Nicolaou, A. , Lynch, M.A, The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat, Neurobiology of Aging, 32, (12), 2011, p2318.e1-2318.e15Journal Article, 2011, DOI
• J. Kevin Murphy, Anne-Marie Miller, R. Thelma, F. Cowley, Fionnuala Cox and Marina A. Lynch, The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation, Neurochemistry International, 58, (2), 2011, p161-168Journal Article, 2011, DOI , URL , TARA - Full Text
• Derek A. Costello, Melanie B. Watson, Thelma R. Cowley, Niamh Murphy, Ciarán Murphy Royal, Cecilia Garlanda & Marina A. Lynch, IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice , Journal of Neuroscience, 31, (10), 2011, p3871-3879Journal Article, 2011, DOI , URL , TARA - Full Text
• Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100-111Journal Article, 2011, DOI , URL , TARA - Full Text
• Lynch MA, Age-related neuroinflammatory changes negatively impact on neuronal function., Frontiers in Aging Neuroscience, 2010, p1-6Journal Article, 2010, DOI , URL , TARA - Full Text
• Lynch MA., The multifaceted profile of activated microglia., Molecular Neurobiology, 40, (2), 2009, p139-156Journal Article, 2009, DOI
• Martin, DS, Walsh M, Miller AM, Skerrett HE, Byrne P, Mandel A, Bolton AE and Lynch MA, A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat, Neuroimmunomodulation, 16, 2009, p400-410Journal Article, 2009, DOI
• Piazza A and Lynch MA, Neuroinflammatory changes increase the impact of stressors on neuronal function., Biochemical Society Transactions, 37, (1), 2009, p303-307Journal Article, 2009, DOI , URL , TARA - Full Text
• Miller AM, Piazza A, Martin DS, Walsh M, Mandel A, Bolton AE and Lynch MA , The deficit in long-term potentiation induced by chronic administration of amyloid-beta is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025., Experimental Gerontology, 44, (4), 2009, p300-304Journal Article, 2009, DOI
• Schmid AW, Lynch MA, Herron CE., The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo., Hippocampus, 19, (7), 2009, p670-676Journal Article, 2009, DOI
• Lyons A, Murphy KJ, Clarke R, Lynch MA, Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain, Journal of Neuroinflammation, 8, (27), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Marina A. Lynch and Kingston H.G. Mills, Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases, Brain, Behavior, and Immunity, 26, (1), 2011, p1-10Journal Article, 2011, DOI , URL , TARA - Full Text
• Costello DA, Lyons A, Browne T, Denieffe S, Cox FF, Lynch MA, Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation., The Journal of Biological Chemistry, 286, (40), 2011, p34722-34732Journal Article, 2011, DOI , URL , TARA - Full Text
• Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Thelma R. Cowely, Nikolay I. Medvedev, Marina A. Lynch, Michael G. Stewart, A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus, Experimental Neurology, 232, (2), 2011, p318-328Journal Article, 2011, DOI , URL , TARA - Full Text
• Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Heather Davies, Frances Colyer, Thelma R. Cowley, Marina Lynch, Michael G. Stewart, Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL, Brain, Behavior, and Immunity, 26, (5), 2012, p778-88Journal Article, 2012, DOI , TARA - Full Text
• F. Fionnuala Cox, Donal Carney, Anne-Marie Miller, Marina A. Lynch, CD200 fusion protein decreases microglial activation in the hippocampus of aged rats, Brain, Behavior, and Immunity, 26, (5), 2012, p789-796Journal Article, 2012, DOI , TARA - Full Text
• Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch MA, Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress., Journal of Alzheimer's disease : JAD, 28, (1), 2011, p147-161Journal Article, 2011, DOI , TARA - Full Text
• Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33Journal Article, 2003, DOI , URL
• Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124Journal Article, 2003, DOI , URL
• Marina A. Lynch, Rodney W. Johnson, The impact of aging on the brain - risk, resilience and repair, Brain, Behavior, and Immunity, 26, (5), 2012, p714-716Journal Article, 2012, DOI , TARA - Full Text
• Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51Journal Article, 2013, DOI , TARA - Full Text
• Jones RS, Minogue AM, Connor TJ, Lynch MA, Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8, (1), 2013, p301-311Journal Article, 2013, DOI , TARA - Full Text
• Cox FF, Berezin V, Bock E, Lynch MA, The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner., Neuroscience, 235, 2013, p141-148Journal Article, 2013, DOI , TARA - Full Text
• Ojo B, Gabbott PL, Rezaie P, Corbett N, Medvedev NI, Cowley TR, Lynch MA, Stewart MG, An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats., Neurochemical research, 38, (6), 2013, p1208-1218Journal Article, 2013, DOI
• Murphy N, Lynch MA, Activation of the P2X" receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1., Journal of neurochemistry, 123, (5), 2012, p761-770Journal Article, 2012, DOI
• Cowley TR, González-Reyes RE, Richardson JC, Virley D, Upton N, Lynch MA, The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon., Neurochemical research, 38, (6), 2013, p1190-5Journal Article, 2013, DOI , TARA - Full Text
• Minogue AM, Barrett JP, Lynch MA, LPS-induced release of IL-6 from glia modulates production of IL-1ß in a JAK2-dependent manner., Journal of neuroinflammation, 9, 2012, p126Journal Article, 2012, DOI , TARA - Full Text
• Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA, Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia., Journal of neuroinflammation, 9, 2012, p107Journal Article, 2012, DOI , TARA - Full Text
• Gallagher JJ, Minogue AM, Lynch MA, Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aß accumulation and microglial activation., Neuro-degenerative diseases, 11, (1), 2013, p33-41Journal Article, 2013, DOI , TARA - Full Text
• Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79Journal Article, 2012, DOI , TARA - Full Text
• Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA, The neuroprotective effect of a specific P2X" receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells., Brain pathology (Zurich, Switzerland), 22, (3), 2012, p295-306Journal Article, 2012, DOI
• Cowley TR, O'Sullivan J, Blau C, Deighan BF, Jones R, Kerskens C, Richardson JC, Virley D, Upton N, Lynch MA, Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP., Neurobiology of aging, 33, (1), 2012, p162-75Journal Article, 2012, DOI , TARA - Full Text
• Blau CW, Cowley TR, O'Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly ÁM, Kerskens CM, Lynch MA, The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability., Neurobiology of aging, 33, (5), 2012, p1005.e23-35Journal Article, 2012, DOI , TARA - Full Text
• O'Reilly JA, Lynch M, Rosiglitazone improves spatial memory and decreases insoluble Aß(1-42) in APP/PS1 mice., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7, (1), 2012, p140-4Journal Article, 2012, DOI , TARA - Full Text
• Murphy KJ, Miller AM, Thelma R, Cowley F, Cox FF, Lynch MA, The age- and amyloid-ß-related increases in Nogo B contribute to microglial activation., Neurochemistry international, 58, (2), 2011, p161-168Journal Article, 2011, DOI
• McGuckin CP, Jurga M, Miller AM, Sarnowska A, Wiedner M, Boyle NT, Lynch MA, Jablonska A, Drela K, Lukomska B, Domanska-Janik K, Kenner L, Moriggl R, Degoul O, Perruisseau-Carrier C, Forraz N, Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction., Archives of biochemistry and biophysics, 534, (1-2), 2013, p88-97Journal Article, 2013, DOI , TARA - Full Text
• Derek A. Costello, and Marina A. Lynch., Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β, Hippocampus, 23, (8), 2013, p696-707Journal Article, 2013, DOI , TARA - Full Text
• Eric J. Downer, Raasay S. Jones, Claire L. McDonald, Eleonora Greco, Sabina Brennan, Thomas J. Connor, Ian H. Robertson, Marina A. Lynch, Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory, Plos One, 8, (5), 2013, ppe63194Journal Article, 2013, DOI , TARA - Full Text
• Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, (3), 2013, p292-301Journal Article, 2013, DOI , TARA - Full Text
• Denieffe S, Kelly RJ, McDonald C, Lyons A, Lynch MA, Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells., Brain, behavior, and immunity, 34, 2013, p86-97Journal Article, 2013, DOI , TARA - Full Text
• Kelly RJ, Minogue AM, Lyons A, Jones RS, Browne TC, Costello DA, Denieffe S, O'Sullivan C, Connor TJ, Lynch MA, Glial Activation in AßPP/PS1 Mice is Associated with Infiltration of IFN"-Producing Cells., Journal of Alzheimer's disease : JAD, 37, (1), 2013, p63-75Journal Article, 2013, DOI , TARA - Full Text
• McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121Journal Article, 2014, DOI , TARA - Full Text
• Downer EJ, Johnston DG, Lynch MA, Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia., Molecular and cellular neurosciences, 56C, 2013, p148-158Journal Article, 2013, DOI , TARA - Full Text
• Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215Journal Article, 2014, DOI
• Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30Journal Article, 2014, TARA - Full Text
• Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17Journal Article, 2014, DOI , URL , TARA - Full Text
• Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 96, (A), 2015, p3-10Journal Article, 2015, DOI , TARA - Full Text
• Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2015Journal Article, 2015, TARA - Full Text

RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.

• Title
  Summary

  Current projects are as follows: 1. Analysis of the role of TLR2 activation in driving inflammation and the impact of decreasing activation on cognitive function, glial activation and amyloid pathology in APP/PS1 mice. 2. Investigation of the effects of a small molecule inhibitor of the NLRP3 inflammasome on glial and neuronal function in APP/PS1 mice. 3. Assessment of the impact of infiltrating IFNγ-producing peripheral cells on neuroinflammation and investigation of consequences of inhibiting cell infiltration by FTY720. 4. Investigation of the role of SLAM (Signalling lymphocyte activation molecule) on microglial function. 5. Identification of the metabolic and functional signatures of different microglial phenotypes

Neuroscience and clinical neurology,

• Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient 2006
• Recipient of Tom Connor Distinguished Researcher Award In Neuroscience 2013
• Elected Fellow of Trinity College, Dublin 1997
• Recipient of the Irish Area Section of the Biochemical Society Silver Medal 2013
• Elected to membership of the Royal Irish Academy May 2009

• British Neuroscience Association 2017

• 2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience