Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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Professor Maeve Caldwell

Professor Maeve Caldwell

Professor in Neuroscience, Physiology

Professor in Neuroscience

3531896 1019

Publications and Further Research Outputs

  • Nistor Paul A., May Paul W., Tamagnini Francesco, Randall Andrew D., Caldwell Maeve A., Long-term culture of pluripotent stem-cell-derived human neurons on diamonds" A substrate for neurodegeneration research and therapy , Biomaterials , 61 , ( ), 2015, p139 - 149Journal Article, 2015, DOI , URL , TARA - Full Text
  • McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA, Loss of MicroRNA-7 Regulation Leads to "-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo., Molecular therapy : the journal of the American Society of Gene Therapy, 2017Journal Article, 2017, DOI
  • Jiménez-Moreno N, Stathakos P, Caldwell MA, Lane JD, Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease., Cells, 2017Journal Article, 2017, DOI
  • Crompton LA, Cordero-Llana O, Caldwell MA, Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders., Brain pathology (Zurich, Switzerland), 2017Journal Article, 2017, DOI
  • Zhu B, Caldwell M, Song B, Development of stem cell-based therapies for Parkinson's disease., The International journal of neuroscience, 2016Journal Article, 2016, DOI
  • Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA, Cullen PJ, Liu J, Zhu X, Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes., Nature medicine, 2016Journal Article, 2016, URL
  • Damseh N, Danson CM, Al-Ashhab M, Abu-Libdeh B, Gallon M, Sharma K, Yaacov B, Coulthard E, Caldwell MA, Edvardson S, Cullen PJ, Elpeleg O, A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration., Neurogenetics, 2015Journal Article, 2015
  • Cordero-Llana Ó, Houghton BC, Rinaldi F, Taylor H, Yáñez-Muñoz RJ, Uney JB, Wong LF, Caldwell MA, Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease., Molecular therapy : the journal of the American Society of Gene Therapy, 2015Journal Article, 2015
  • McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ, Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation., Current biology : CB, 2014Journal Article, 2014
  • Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA, Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain., Experimental neurology, 2014Journal Article, 2014
  • Rinaldi F, Hartfield EM, Crompton LA, Badger JL, Glover CP, Kelly CM, Rosser AE, Uney JB, Caldwell MA, Cross-regulation of Connexin43 and ß-catenin influences differentiation of human neural progenitor cells., Cell death & disease, 2014Journal Article, 2014
  • Rinaldi F, Caldwell MA, Modeling astrocytic contribution toward neurodegeneration with pluripotent stem cells: focus on Alzheimer's and Parkinson's diseases., Neuroreport, 2013Journal Article, 2013
  • Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA, Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling., Stem cell research, 2013Journal Article, 2013
  • Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB, Caldwell MA, Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts., Regenerative medicine, 2012Journal Article, 2012
  • Höglinger GU, Barker RA, Hagg T, Arias-Carrión O, Caldwell MA, Hirsch EC, Quantitative evaluation of the human subventricular zone., Brain : a journal of neurology, 2012Journal Article, 2012
  • Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Case CP, Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness., Nature nanotechnology, 2011Journal Article, 2011
  • Cordero-Llana O, Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Caldwell MA, Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells., Cell Death and Differentiation, 2011Journal Article, 2011
  • Hartfield EM, Rinaldi F, Glover CP, Wong LF, Caldwell MA, Uney JB, Connexin 36 expression regulates neuronal differentiation from neural progenitor cells., PloS one, 2011Journal Article, 2011
  • Barraud P, He X, Zhao C, Caldwell MA, Franklin RJ, FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures., Experimental cell research, 2010Journal Article, 2010
  • Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA, Newson R, Lyng F, Case CP, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase., Mutation research, 2010Journal Article, 2010
  • O'Keeffe GC, Barker RA, Caldwell MA, Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain., Cell cycle (Georgetown, Tex.), 2009Journal Article, 2009
  • O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA, Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF., Proceedings of the National Academy of Sciences of the United States of America, 2009Journal Article, 2009
  • Thomas M, Tyers P, Lazic SE, Caldwell MA, Barker RA, Beazley L, Ziman M, Graft outcomes influenced by co-expression of Pax7 in graft and host tissue., Journal of anatomy, 2009Journal Article, 2009
  • Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB, Twist-1 regulates the miR-199a/214 cluster during development., Nucleic acids research, 2009Journal Article, 2009
  • Kelly S, Caldwell M, Keasey MP, Cooke JA, Uney JB, Identifying neural progenitor cells in the adult brain., Methods in molecular biology (Clifton, N.J.), 2009Journal Article, 2009
  • Hall PE, Lathia JD, Caldwell MA, Ffrench-Constant C, Laminin enhances the growth of human neural stem cells in defined culture media., BMC neuroscience, 2008Journal Article, 2008
  • O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA, Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease., Brain : a journal of neurology, 2008Journal Article, 2008
  • Barraud P, He X, Caldwell MA, Franklin RJ, Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures., BMC neuroscience, 2008Journal Article, 2008
  • Chandran S, Caldwell M, Allen N, Introduction: stem cells and brain repair., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008Journal Article, 2008
  • Ormerod BK, Palmer TD, Caldwell MA, Neurodegeneration and cell replacement., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008Journal Article, 2008
  • Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin RJ, Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells., The European journal of neuroscience, 2007Journal Article, 2007
  • Prosser HM, Bradley A, Caldwell MA, Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation., The European journal of neuroscience, 2007Journal Article, 2007
  • Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS., The Journal of comparative neurology, 2007Journal Article, 2007
  • Anderson L, Caldwell MA, Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease., Neurobiology of disease, 2007Journal Article, 2007
  • Lim JC, Wolpaw AJ, Caldwell MA, Hladky SB, Barrand MA, Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells., Brain research, 2007Journal Article, 2007
  • Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S, Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells., Brain : a journal of neurology, 2007Journal Article, 2007
  • Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA, Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo., Experimental neurology, 2007Journal Article, 2007
  • Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C, Integrins are markers of human neural stem cells., Stem cells (Dayton, Ohio), 2006Journal Article, 2006
  • Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S, Astrocytes promote neurogenesis from oligodendrocyte precursor cells., The European journal of neuroscience, 2006Journal Article, 2006
  • Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N, Chandran S, Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion., Stem cells (Dayton, Ohio), 2006Journal Article, 2006
  • Caldwell MA, He X, Svendsen CN, 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro., The European journal of neuroscience, 2005Journal Article, 2005
  • Strappe PM, Hampton DW, Brown D, Cachon-Gonzalez B, Caldwell M, Fawcett JW, Lever AM, Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage., Retrovirology, 2005Journal Article, 2005
  • Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN, Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF., Experimental neurology, 2004Journal Article, 2004
  • Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA, Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease., The international journal of biochemistry & cell biology, 2004Journal Article, 2004
  • Le Belle JE, Caldwell MA, Svendsen CN, Improving the survival of human CNS precursor-derived neurons after transplantation., Journal of neuroscience research, 2004Journal Article, 2004
  • Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN, Gene expression in human neural stem cells: effects of leukemia inhibitory factor., Journal of neurochemistry, 2003Journal Article, 2003
  • Barker RA, Jain M, Armstrong RJ, Caldwell MA, Stem cells and neurological disease., Journal of neurology, neurosurgery, and psychiatry, 2003Journal Article, 2003
  • Lewis SJ, Caldwell MA, Barker RA, Modern therapeutic approaches in Parkinson's disease., Expert reviews in molecular medicine, 2003Journal Article, 2003
  • Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN, Regional specification of rodent and human neurospheres., Brain research. Developmental brain research, 2002Journal Article, 2002
  • Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P, Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study., Lancet (London, England), 2002Journal Article, 2002
  • Watts C, McConkey H, Anderson L, Caldwell M, Anatomical perspectives on adult neural stem cells., Journal of anatomy, 2005Journal Article, 2005
  • Earley B, Canney M, Clune B, Caldwell M, Leonard BE, Junien JL, The effects of MK-801, ifenprodil, JO 1784, JO 1994 and JO 1997 on PK 11195 receptor binding, nitric oxide synthase (NO synthase) activity and infarct volume in a mouse model of focal cerebral ischaemia., Neurochemistry international, 1996Journal Article, 1996
  • Caldwell M, O'Neill M, Earley B, Kelly JP, Leonard BE, NG-nitro-L-arginine methyl ester protects against lipid peroxidation in the gerbil following cerebral ischaemia., European journal of pharmacology, 1995Journal Article, 1995
  • O'Neill M, Caldwell M, Earley B, Canney M, O'Halloran A, Kelly J, Leonard BE, Junien JL, The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia., European journal of pharmacology, 1995Journal Article, 1995
  • Maginn M, Caldwell M, Kelly JP, Leonard BE, The effect of 2-amino-3-phosphonopropionic acid (AP-3) in the gerbil model of cerebral ischaemia., European journal of pharmacology, 1995Journal Article, 1995
  • Caldwell M, O'Neill M, Earley B, Leonard B, NG-Nitro-L-arginine protects against ischaemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil., European journal of pharmacology, 1994Journal Article, 1994
  • Caldwell MA, He X, Wilkie N, Pollack S, Marshall G, Wafford KA, Svendsen CN, Growth factors regulate the survival and fate of cells derived from human neurospheres., Nature biotechnology, 2001Journal Article, 2001
  • Caldwell MA, Recent advances in neuralstem cell technologies., Trends in neurosciences, 2001Journal Article, 2001
  • Besret L, Caldwell MA, Torres EM, Dunnett SB, Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats., European journal of pharmacology, 2000Journal Article, 2000
  • Ostenfeld T, Caldwell MA, Prowse KR, Linskens MH, Jauniaux E, Svendsen CN, Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation., Experimental neurology, 2000Journal Article, 2000
  • Svendsen CN, Caldwell MA, Neural stem cells in the developing central nervous system: implications for cell therapy through transplantation., Progress in brain research, 2000Journal Article, 2000
  • Svendsen CN, Caldwell MA, Ostenfeld T, Human neural stem cells: isolation, expansion and transplantation., Brain pathology (Zurich, Switzerland), 1999Journal Article, 1999
  • Ostenfeld T, Horn P, Aardal C, Orpen I, Caldwell MA, Svendsen CN, Mouse epidermal growth factor-responsive neural precursor cells increase the survival and functional capacity of embryonic rat dopamine neurons in vitro., Neuroreport, 1999Journal Article, 1999
  • Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA, A new method for the rapid and long term growth of human neural precursor cells., Journal of neuroscience methods, 1998Journal Article, 1998
  • Caldwell MA, Svendsen CN, Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells., Experimental neurology, 1998Journal Article, 1998
  • Watts C, Caldwell MA, Dunnett SB, The development of intracerebral cell-suspension implants is influenced by the grafting medium., Cell transplantation, 1998Journal Article, 1998
  • Svendsen CN, Caldwell MA, Shen J, ter Borg MG, Rosser AE, Tyers P, Karmiol S, Dunnett SB, Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease., Experimental neurology, 1997Journal Article, 1997
  • Caldwell MA, Reymann JM, Allain H, Leonard BE, Bentué-Ferrer D, Lisuride prevents learning and memory impairment and attenuates the increase in extracellular dopamine induced by transient global cerebral ischemia in rats., Brain research, 1997Journal Article, 1997
  • Caldwell MA, Reymann JM, Bentue-Ferrer D, Allain H, Leonard BE, The dopamine agonists lisuride and piribedil protect against behavioural and histological changes following 4-vessel occlusion in the rat., Neuropsychobiology, 1996Journal Article, 1996
  • Sarah F. McComish, Maeve A. Caldwell, Generation of defined neural populations from pluripotent stem cells, Philosophical Transactions of the Royal Society B: Biological Sciences, 373, (1750), 2018, p20170214Journal Article, 2018, DOI
  • Stathakos P, Jimenez-Moreno N, Crompton L, Nistor P, Caldwell MA, Lane JD, Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson's Disease Research., Methods in molecular biology (Clifton, N.J.), 2019Journal Article, 2019
  • Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells, 2018, pp3 - 20, [Maeve A. Caldwell]Book Chapter, 2018
  • Maeve A. Caldwell, Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes, Nature Nanotechnology, 13, 2018, p427 - 433Journal Article, 2018, DOI
  • Maughan, J. and Gouveia, P.J. and Gonzalez, J.G. and Leahy, L.M. and Woods, I. and O'Connor, C. and McGuire, T. and Garcia, J.R. and O†Shea, D.G. and McComish, S.F. and Kennedy, O.D. and Caldwell, M.A. and Dervan, A. and Coleman, J.N. and O'Brien, F.J., Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications, Applied Materials Today, 29, (101629), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
  • MacMahon Copas AN, McComish SF, Fletcher JM, Caldwell MA., The Pathogenesis of Parkinson's Disease: A Complex Interplay Between Astrocytes, Microglia, and T Lymphocytes?, Frontiers in neurology, 12, 2021, p666737Journal Article, 2021, DOI
  • McComish S.F., MacMahon Copas A.N., Caldwell M.A., Human Brain-Based Models Provide a Powerful Tool for the Advancement of Parkinson"s Disease Research and Therapeutic Development, Frontiers in Neuroscience, 16, 2022Journal Article, 2022, DOI
  • Stathakos P., Jimenez-Moreno N., Crompton L.A., Nistor P.A., Badger J.L., Barbuti P.A., Kerrigan T.L., Randall A.D., Caldwell M.A., Lane J.D., A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons, Autophagy, 17, (4), 2021, p855 - 871, p855-871Journal Article, 2021, DOI
  • Crompton L.A., McComish S.F., Stathakos P., Cordero-Llana O., Lane J.D., Caldwell M.A., Efficient and scalable generation of human ventral midbrain astrocytes from human-induced pluripotent stem cells, Journal of Visualized Experiments, (176), 2021Journal Article, 2021, DOI
  • Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells , 2018, pp3 - 20, [Maeve A. Caldwell]Book Chapter, DOI
  • Derivation of Neural Stem Cells from the Developing and Adult Human Brain in, Human Neural Stem Cells, 2018, pp3 - 20, [Maeve A. Caldwell]Book Chapter, DOI

Research Expertise

  • Title
    Examining the interplay of the immune system with brain cells in Parkinson's disease
    Summary
    Age is the primary risk factor for the development of a neurodegenerative disease such as Parkinson's disease with projected disease burden expected to increase 2-fold in Ireland by 2036. The overall burden is likely to keep increasing unless mechanistic based strategies for alleviating this age related neural decline are discovered and exploited for prevention or therapy. The potential role of the astrocytes as either a cellular target or as a secondary participant in the pathogenesis of neurodegenerative disease has gained attention in recent years as has the role of the immune system. However, our understanding of astrocytic mechanisms in response to stress/injury is incomplete compared to that of neurons and our understanding of the role the immune system plays is still in its infancy. The aim of this project is to determine the interplay between T cells (specifically Th17 cells) and astrocytes and how either cell type alone or following stimulation of the astrocytes with microglial secreted factors affects the survival of midbrain dopamine neurons. We will generate midbrain dopamine neurons and midbrain astrocytes from a number of induced pluripotent stem cell lines, including idiopathic Parkinson's and normal controls and we will isolate Th17 lymphocytes from whole blood of Parkinson's patients and controls. In addition, we will utilise Mass Spectroscopy to determine what factors are secreted by astrocytes. Specifically we will collect astrocyte conditioned media before and after their exposure to Th17 cells or microglial secreted factors and determine what factors are detrimental to dopamine neuronal survival. This body of work will determine how the interplay of the immune system with cells of the brain is implicated in the pathogenesis of Parkinson's disease
    Funding Agency
    HRB
    Date From
    01/04/2020
    Date To
    31/01/2024
  • Title
    PARKIE: Parkinson's community Awareness of Research; emphasis on Knowledge and Information Exchange
    Summary
    Funding Agency
    HRB
    Date From
    01/11/2022
    Date To
    31/10/2023
  • Title
    Apolipoprotein-E genotype influences inflammation in Alzheimer's Disease
    Summary
    Funding Agency
    SFI
    Date From
    01/10/2020
    Date To
    31/09/2024