Professor Michael Capra

• Higgins E, Capra M, Schwartz ME, Smith FJD, McLean WHI, Irvine AD, Resolution of the plantar hyperkeratosis of pachyonychia congenita during chemotherapy for Ewing sarcoma , British Journal of Dermatology , 169 , (6 ), 2013, p1357 - 1360Journal Article, 2013, TARA - Full Text
• Stacey AW and Bowman R and Foster A and Kivelä TT and Munier FL and Cassoux N and Fabian ID and Global Retinoblastoma Study Group, Incidence of Retinoblastoma Has Increased: Results from 40 European Countries., Ophthalmology, 128, (9), 2021, p1369 - 1371Journal Article, 2021, DOI
• Goto H, Geoerger B, DuBois S, Grilley-Olson J, van Tilburg C, Schulte J, Kang H, Tahara M, Boni V, Perreault S, Capra M, Reeves J, Brega N, Childs B, Doz F, ACTIVITY OF LAROTRECTINIB IN PEDIATRIC TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION CANCER PATIENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS, Neuro-Oncology, International Society of Pediatric Neuro-oncology (ISPNO), Karuzaiwa, Japan, 13-16 Dec 2020, 22, (Supplement_3), 2020, ppiii305 - iii305Published Abstract, 2020, DOI
• Doz F, Geoerger B, DuBois S, Grilley-Olson J, van Tilburg C, Italiano A, Lissat A, Jin Kang H, Tahara M, Boni V, Perreault S, Capra M, Nanda S, Drilon A, ACTIVITY OF LAROTRECTINIB IN TRK FUSION CANCER PATIENTS WITH PRIMARY CENTRAL NERVOUS SYSTEM TUMORS, Neuro-oncology, Society of Neuro-oncology (SNO), Phoenix, Arizona, 22-24 Nov 2020, 21, (Suppl 6), 2019, ppvi231 - vi231Published Abstract, 2019, DOI
• Kilday JP, Caldarelli M, Massimi L, Chen RH, Lee YY, Liang ML, Parkes J, Naiker T, van Veelen ML, Michiels E, Mallucci C, Pettorini B, Meijer L, Bartels U, Intracystic interferon-alpha in pediatric craniopharyngioma patients: an international multicenter assessment on behalf of SIOPE and ISPN., Neuro-oncology, 2017, p1398 - 1407Journal Article, 2017, DOI
• Kilday J, Massimi L, Caldarelli M, Lee Y, Chen H, Yiang M, Parkes J, Naiker T, van Veelen M, Michiels E, Pettorini B, Mallucci C, Meijer L, Dorfer C, Bartels U, INTRACYSTIC INTERFERON-ALPHA IN PAEDIATRIC CRANIOPHARYNGIOMA PATIENTS: AN INTERNATIONAL MULTI-CENTRE ASSESSMENT ON BEHALF OF SIOP-E AND ISPN, Neuro-Oncology, ISPNO 2016, Liverpool, UK, 13-15 June 2016, 18, (Suppl 3), 2016, ppiii20Published Abstract, 2016, DOI
• Cullinan N, Caird J, Capra M, Pears J, Owens C, Crimmins D, PAEDIATRIC LOW GRADE GLIOMAS - IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT, Neuro-Oncology, ISPNO 2016, Liverpool, UK, 13-15 June 2016, 18, (Suppl 3), 2016, ppiii89Published Abstract, 2016, DOI
• Mahamdallie SS, Hanks S, Karlin KL, Zachariou A, Perdeaux ER, Ruark E, Shaw CA, Renwick A, Ramsay E, Yost S, Elliott A, Birch J, Capra M, Gray J, Rahman N, Mutations in the transcriptional repressor REST predispose to Wilms tumor., Nature genetics, 47, (12), 2015, p1471 - 1474Journal Article, 2015, DOI , URL
• Khanani MF, Hawkins C, Shroff M, Dirks P, Capra M, Burger PC, Bouffet E, Pilomyxoid astrocytoma in a patient with neurofibromatosis., Pediatric blood & cancer, 46, (3), 2006, p377 - 380Journal Article, 2006, DOI
• Chew S, Gleeson JP, McCarthy A, Watson GA, O'Dwyer R, Nicholson S, Capra M, Owens C, McDermott M, Daly P, Grant C., Leptomeningeal Relapse of Embryonal Rhabdomyosarcoma after 15 years., Irish Medical Journal, 112, (10), 2020, p1026Journal Article, 2020, DOI , URL
• Javadpour M, Amoo M, Crimmins D, Caird J, Daly P, Pears J, Owens C, Capra M, Cody D., Endoscopic extended transsphenoidal surgery for newly diagnosed paediatric craniopharyngiomas., Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 37, 2021, p1547 - 1561Journal Article, 2021, DOI
• Alken S, Owens C, Gilham C, Grant C, Pears J, Deady S, O'Marcaigh A, Capra M, O'Mahony D, Smith O, Walsh PM., Survival of childhood and adolescent/young adult (AYA) cancer patients in Ireland during 1994-2013: comparisons by age., Ir J Med Sci, 189, (4), 2020, p1223-1236Journal Article, 2020, DOI
• Clarke M, Mackay A, Ismer B, Pickles JC, Tatevossian RG, Newman S, Bale TA, Stoler I, Izquierdo E, Temelso S, Carvalho DM, Molinari V, Burford A, Howell L, Virasami A, Fairchild AR, Avery A, Chalker J, Kristiansen M, Haupfear K, Dalton JD, Orisme W, Wen J, Hubank M, Kurian KM, Rowe C, Maybury M, Crosier S, Knipstein J, Schüller U, Kordes U, Kram DE, Snuderl M, Bridges L, Martin AJ, Doey LJ, Al-Sarraj S, Chandler C, Zebian B, Cairns C, Natrajan R, Boult JKR, Robinson SP, Sill M, Dunkel IJ, Gilheeney SW, Rosenblum MK, Hughes D, Proszek PZ, Macdonald TJ, Preusser M, Haberler C, Slavc I, Packer R, Ng HK, Caspi S, Popovi" M, Faganel Kotnik B, Wood MD, Baird L, Davare MA, Solomon DA, Olsen TK, Brandal P, Farrell M, Cryan JB, Capra M, Karremann M, Schittenhelm J, Schuhmann MU, Ebinger M, Dinjens WNM, Kerl K, Hettmer S, Pietsch T, Andreiuolo F, Driever PH, Korshunov A, Hiddingh L, Worst BC, Sturm D, Zuckermann M, Witt O, Bloom T, Mitchell C, Miele E, Colafati GS, Diomedi-Camassei F, Bailey S, Moore AS, Hassall TEG, Lowis SP, Tsoli M, Cowley MJ, Ziegler DS, Karajannis MA, Aquilina K, Hargrave DR, Carceller F, Marshall LV, von Deimling A, Kramm CM, Pfister SM, Sahm F, Baker SJ, Mastronuzzi A, Carai A, Vinci M, Capper D, Popov S, Ellison DW, Jacques TS, Jones DTW, Jones C., Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes., Cancer discovery, 10, (7), 2020, p942-963Journal Article, 2020, DOI
• Quinlan CS, Capra M, Dempsey M., Paediatric malignant melanoma in Ireland: A population study and review of the literature., Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 72, (8), 2019, p1388-1395Journal Article, 2019, DOI
• Irvine I, Walshe T, Capra M, Hayes R., Scurvy: an unusual complication of paediatric cancer treatment., Skeletal Radiology, 48, (6), 2019, p995 - 998Journal Article, 2019, DOI
• Smeland S, Bielack SS, Whelan J, Bernstein M, Hogendoorn P, Krailo MD, Gorlick R, Janeway KA, Ingleby FC, Anninga J, Antal I, Arndt C, Brown KLB, Butterfass-Bahloul T, Calaminus G, Capra M, Dhooge C, Eriksson M, Flanagan AM, Friedel G, Gebhardt MC, Gelderblom H, Goldsby R, Grier HE, Grimer R, Hawkins DS, Hecker-Nolting S, Sundby Hall K, Isakoff MS, Jovic G, Kühne T, Kager L, von Kalle T, Kabickova E, Lang S, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Mayer-Steinacker R, Meyers PA, Nagarajan R, Randall RL, Reichardt P, Renard M, Rechnitzer C, Schwartz CL, Strauss S, Teot L, Timmermann B, Sydes MR, Marina N., Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort., Eur J Cancer, 109, 2019, p36-50Journal Article, 2019, DOI
• Brock PR, Maibach R, Childs M, Rajput K, Roebuck D, Sullivan MJ, Laithier V, Ronghe M, Dall'Igna P, Hiyama E, Brichard B, Skeen J, Mateos ME, Capra M, Rangaswami AA, Ansari M, Rechnitzer C, Veal GJ, Covezzoli A, Brugières L, Perilongo G, Czauderna P, Morland B, Neuwelt EA., Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss., The New England journal of medicine, 378, (25), 2018, p2376-2385Journal Article, 2018, DOI
• Carroll C, Clinton F, Smith A, Fox A, Capra M, Pears J, Owens C., Revised antiemetics guidelines and the impact on nutritional status during induction chemotherapy in children with high-risk neuroblastoma., Pediatric blood & cancer, 65, (12), 2018, pe27386Journal Article, 2018, DOI
• Lee KA, O'Sullivan C, Daly P, Pears J, Owens C, Timmermann B, Ares C, Combs SE, Indelicato D, Capra M., Proton therapy in paediatric oncology: an Irish perspective., Ir J Med Sci, 186, (3), 2017, p577-582Journal Article, 2017, DOI
• Butler GH, Boyle M, Lynch SA, Ryan S, McDermott M, Capra M., One to Watch: A Germ Cell Tumor Arising in an Undescended Testicle in Rubinstein-Taybi Syndrome., Journal of pediatric hematology/oncology, 38, (6), 2016, pe191-2Journal Article, 2016, DOI
• Fabian ID, Stacey AW, Foster A, Kivelä TT, Munier FL, Keren-Froim N, Gomel N, Cassoux N, Sagoo MS, Reddy MA, Harby LA, Zondervan M, Bascaran C, Abdallah E, Abdullahi SU, Boubacar SA, Ademola-Popoola DS, Adio A, Aghaji AE, Portabella SA, Alfa Bio AI, Ali AM, Alia DB, All-Eriksson C, Almeida AA, Alsawidi KM, Antonino R, Astbury NJ, Atsiaya R, Balaguer J, Balwierz W, Barranco H, Popovic MB, Benmiloud S, Guebessi NB, Berete RC, Biddulph SJ, Biewald EM, Blum S, Bobrova N, Boehme M, Bornfeld N, Bouda GC, Bouguila H, Boumedane A, Brichard BG, L MC, Castela G, Català-Mora J, Chantada GL, Chernodrinska VS, Chiwanga FS, Cieslik K, Comsa C, Correa Llano MG, Csóka M, Da Gama IV, Davidson A, Potter P, Desjardins L, Dragomir MD, Bruyn MD, Kettani AE, Elbahi AM, Elgalaly D, Elhaddad AM, Ali Elhassan MM, Elzembely MM, Essuman VA, Evina TGA, Fasina O, Fernández-Teijeiro A, Gandiwa M, Aldana DG, Geel JA, Gizachew Z, Gregersen PA, Guedenon KM, Hadjistilianou T, Hassan S, Hederova S, Hessissen L, Hordofa DF, Hummlen M, Husakova K, Ida R, Ilic VR, Jenkinson H, Amani Kabesha TB, Kabore RL, Kalinaki A, Kapelushnik N, Kardava T, Kemilev PK, Kepak T, Khotenashvili Z, Klett A, Kosh Komba Palet JE, Krivaitiene D, Kruger M, Kyara A, Lachmann ES, Latinovi" S, Lecuona K, Lukamba RM, Lumbroso L, Lysytsia L, Maka E, Makan M, Manda C, Begue NM, Matende IO, Matua M, Mayet I, Mbumba FB, Mengesha AA, Midena E, Mndeme FG, Mohamedani AA, Moll AC, Moreira C, Msina MS, Msukwa G, Muma KI, Murgoi G, Musa KO, Mustak H, Muyen OM, Naidu G, Naumenko L, Ndoye Roth PA, Neroev V, Nikitovic M, Nkanga ED, Nkumbe H, Nyaywa M, Obono-Obiang G, Oguego NC, Olechowski A, Oscar AH, Osei-Bonsu P, Painter SL, Paintsil V, Paiva L, Papyan R, Parrozzani R, Parulekar M, Pawinska-Wasikowska K, Peri" S, Philbert R, Pochop P, Polyakov VG, Pompe MT, Pons JJ, Raobela L, Renner LA, Reynders D, Ribadu D, Riheia MM, Ritter-Sovinz P, Saakyan S, Said AM, Román Pacheco SS, Scanlan TA, Schoeman J, Seregard S, Sherief ST, Cheikh SS, Silva S, Sorochynska T, Ssali G, Stathopoulos C, Kranjc BS, Stones DK, Svojgr K, Sylla F, Tamamyan G, Tandili A, Tateshi B, Theophile T, Traoré F, Tyau-Tyau H, Umar AB, Urbak SF, Ushakova TL, Valeina S, Hoefen Wijsard MV, Veleva-Krasteva NV, Viksnins M, Wackernagel W, Waddell K, Wade PD, Wali Nigeria AH, Wime AD, Dod CW, Yanga JM, Yarovaya VA, Yarovoy AA, Zein E, Sharabi S, Zhilyaeva K, Ziko OA, Bowman R., Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries., The British journal of ophthalmology, 2020Journal Article, 2020, DOI
• Cullinan N, Capra M, McVeigh T, Genetic Testing for Cancer Predisposition Syndromes in Adolescents and Young Adults, Current Genetic Medicine Reports, 8, 2020, p61 - 71Journal Article, 2020, DOI
• Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M, EURAMOS collaborators., EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment., Annals of oncology : official journal of the European Society for Medical Oncology, 26, (2), 2015, p407-414Journal Article, 2015, DOI
• Loughnane, P, Clinton F, Capra M, Feasibility of a New Screening Tool to Optimise the Management of Patients with Chemotherapy Induced Peripheral Neuropathy, Association Of Paediatric Chartered Physiotherapists Journal, 6, (1), 2015, p70 - 78Journal Article, 2015, URL
• Uwineza A, Gill H, Buckley P, Owens C, Capra M, O'Sullivan C, McDermott M, Brett F, Farrell M, Pears J, O'Sullivan MJ., Rhabdoid tumor: the Irish experience 1986-2013., Cancer genetics, 207, (9), 2014, p398-402Journal Article, 2014, DOI
• O'Halloran PJ, Farrell M, Caird J, Capra M, O'Brien D., Paediatric spinal glioblastoma: case report and review of therapeutic strategies., Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 29, (3), 2013, p367-374Journal Article, 2013, DOI
• Clinton F, Dowling M, Capra M., An audit of chemotherapy-induced nausea and vomiting in children., Nursing children and young people, 24, (7), 2012, p18-23Journal Article, 2012, DOI , URL
• O'Grady MJ, McGrath N, Quinn FM, Capra ML, McDermott MB, Murphy NP., Spermatogenesis in a prepubertal boy., The Journal of pediatrics, 161, (2), 2012, p369-369.e1Journal Article, 2012, DOI
• Maibach R, Roebuck D, Brugieres L, Capra M, Brock P, Dall'Igna P, Otte JB, De Camargo B, Zsiros J, Zimmermann A, Aronson D, Childs M, Scopinaro M, Morland B, Plaschkes J, Czauderna P, Perilongo G., Prognostic stratification for children with hepatoblastoma: the SIOPEL experience., Eur J Cancer, 48, (10), 2012, p1543-1549Journal Article, 2012, DOI
• Hawkes CP, Betts DR, O'Brien J, O'Sullivan MJ, Capra M., Congenital sacrococcygeal PNET and chemotherapy., Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology, 33, (3), 2012, p182-184Journal Article, 2012, DOI , URL
• Kinsella C, Russell J, Mannion D, Capra M, Neuroblastoma and life-threatening tracheal obstruction: a case report and literature review, International Journal of Pediatric Otorhinolaryngology Extra, 6, (3), 2011, p146 - 148Journal Article, 2011, DOI
• Sivaprakasam P, Gupta AA, Greenberg ML, Capra M, Nathan PC., Survival and long-term outcomes in children with hepatoblastoma treated with continuous infusion of cisplatin and doxorubicin., Journal of pediatric hematology/oncology, 33, (6), 2011, pe226-30Journal Article, 2011, DOI
• Curry S, Bacon CL, Robinson I, Capra M, Smith OP., Leukaemic alveolar rhabdomyosarcoma., British journal of haematology, 151, (3), 2010, p208Journal Article, 2010, DOI
• Bouffet E, Capra M, Bartels U., Salvage chemotherapy for metastatic and recurrent ependymoma of childhood., Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 25, (10), 2009, p1293-1301Journal Article, 2009, DOI
• Walsh PM, Byrne J, Capra M, Comber H., Childhood cancer survival in Ireland: temporal, regional and deprivation-related patterns., Eur J Cancer, 47, (12), 2011, p1852-1862Journal Article, 2011, DOI
• Capra M, Hewitt M, Radford M, Hayward J, Weston CL, Machin D, Children's Cancer and Leukaemia Group., Long-term outcome in children with Hodgkin's lymphoma: the United Kingdom Children's Cancer Study Group HD82 trial., Eur J Cancer, 43, (7), 2007, p1171-1179Journal Article, 2007, DOI
• Cada M, Gerstle JT, Traubici J, Ngan BY, Capra ML., Approach to diagnosis and treatment of pediatric primary tumors of the diaphragm., Journal of pediatric surgery, 41, (10), 2006, p1722-1726Journal Article, 2006, DOI
• MacLean JE, Mahant S, Bitnun A, Read S, Capra M, Solomon M., Family matters: a twelve-year-old male with respiratory symptoms, cachexia and clubbing, Journal of paediatrics and child health, 42, (11), 2006, p739-742Journal Article, 2006, DOI
• Lacy J, Capra M, Allen L., Endodermal sinus tumor of the infant vagina treated exclusively with chemotherapy., Journal of pediatric hematology/oncology, 28, (11), 2006, p768-771Journal Article, 2006, DOI
• Larouche V, Capra M, Huang A, Bartels U, Bouffet E., Supratentorial primitive neuroectodermal tumors in young children., Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24, (35), 2006, p5609; author reply 5609-10Journal Article, 2006, DOI
• Tomlinson D, Capra M, Gammon J, Volpe J, Barrera M, Hinds PS, Bouffet E, Geenberg ML, Baruchel S, Llewellyn-Thomas HA, Sung L., Parental decision making in pediatric cancer end-of-life care: using focus group methodology as a prephase to seek participant design input., European journal of oncology nursing : the official journal of European Oncology Nursing Society, 10, (3), 2006, p198-206Journal Article, 2006, DOI
• Gupta AA, Capra M, Papaioannou V, Hall G, Maze R, Dix D, Weitzman S., Low incidence of ototoxicity with continuous infusion of cisplatin in the treatment of pediatric germ cell tumors., Journal of pediatric hematology/oncology, 28, (2), 2006, p91-94Journal Article, 2006, DOI
• Holland J, Cada M, Ling SC, Capra ML, Bernstein S., Melena: a rare presentation of childhood Burkitt's lymphoma., CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 173, (3), 2005, p247-248Journal Article, 2005, DOI
• Capra M, Wherrett D, Weitzman S, Dirks P, Hawkins C, Bouffet E., Pituitary stalk thickening and primary central nervous system lymphoma., Journal of neuro-oncology, 67, (1-2), 2004, p227-231Journal Article, 2004, DOI
• Chow LM, Capra M, Levichek Z, Koren G, Grant RM., Toxic ingestion of 6-mercaptopurine by young siblings of pediatric oncology patients., The Journal of pediatrics, 144, (5), 2004, p669-671Journal Article, 2004, DOI
• Capra M, Hargrave D, Bartels U, Hyder D, Huang A, Bouffet E., Central nervous system tumours in adolescents., Eur J Cancer, 39, (18), 2003, p2643-2650Journal Article, 2003, DOI
• Atra A, Higgs E, Capra M, Elsworth A, Imeson J, Radford M, Pinkerton R, Hewitt M, United Kingdom Children Cancer Study Group (UKCCSG)/Hodgkin's Disease Group., Isolated parenchymal lung involvement in children with stage IV Hodgkin's disease: results of the UKCCSG HD8201 and HD9201 studies., British journal of haematology, 119, (2), 2002, p441-444Journal Article, 2002, DOI
• Atra A, Higgs E, Capra M, Elsworth A, Imeson J, Radford M, Hewitt M, UKCCSG/Hodgkin's Disease Group., ChlVPP chemotherapy in children with stage IV Hodgkin's disease: results of the UKCCSG HD 8201 and HD 9201 studies., British journal of haematology, 119, (3), 2002, p647-651Journal Article, 2002, DOI
• Capra ML, Walker DA, Mohammed WM, Kapila L, Barbor PR, Sokal M, Robson K, Hewitt M, Stewart R., Wilms' tumor: a 25-year review of the role of preoperative chemotherapy., Journal of pediatric surgery, 34, (4), 1999, p579-582Journal Article, 1999, DOI
• Robinson RO, Ferrie CD, Capra M, Maisey MN., Positron emission tomography and the central nervous system., Archives of disease in childhood, 81, (3), 1999, p263-270Journal Article, 1999, DOI
• Barrera M, Spencer L, Schneiderman G, Tallett S, Nicholas N, Capra M, Jovcevska V, Dagostino N, Bereaved Parents continuing relationship with their deceased children at six months post-loss, Journal of Palliative Care, 16th International Congress on Care of the Terminally Ill, Montreal, Sept 26-29, 2006, 22, (3), SAGE Publications, 2006, pp191 - 192Published Abstract, 2006, DOI
• Le G, Comey N, Capra M, Pears J, Owens C, O'Marcaigh A, Elevated serum lactate dehydrogenase after stem cell mobilisation predicts successful stem cell collection in children, Bone Marrow Transplantation, European Society for Blood and Marrow Transplantation - 46th Annual Meeting, 29th Aug 2020, 55, (Suppl 1), Springer Nature, 2020, pp692 - 693Published Abstract, 2020, DOI , URL
• Fabian ID et al, on behalf of the Global Retinoblastoma Study Group, Global Retinoblastoma Presentation and Analysis by National Income Level, JAMA Oncology, 6, (5), 2020, p685 - 695Journal Article, 2020, DOI , URL
• DS Ziegler, F Doz, B Geoerger, S Dubois, JE Grilley-Olson, C van Tilburg, A Italiano, A Lissat, J-H Kang, M Tahara, V Boni, S Perreault, M Capra, S Nanda, N Brega, A Holynskyj, DS Hong, D Hyman, A Drilo, Activity of larotrectinib in TRK fusion cancer patients with primary central nervous system tumours, Annals of Oncology, ESMO, Singapore, 22-24 Nov 2019, 30, (Supplement 9), 2019, ppix124-Published Abstract, 2019, DOI
• David Hyman, Shivaani Kummar, Anna Farago, Birgit Geoerger, Morten Mau-Sorensen, Matthew Taylor, Elena Garralda, Ramamoorthy Nagasubramanian, Michael Natheson, Lucy Song, Michael Capra, Mette Jorgensen, Alan Ho, Neerav Shukla, Steve Smith, Xin Huang, Brian Tuch, Nora Ku, Theodore W Laetsch, Alexander Drilon, David Hong, Abstract CT127: Phase I and expanded access experience of LOXO-195 (BAY 2731954), a selective next-generation TRK inhibitor (TRKi), Cancer Research, American Association of Cancer Research (AACR)), Atlanta, USA, 29th Mar-3rd Apr , 79, (13 Suppl), AACR, 2019, ppCT127-Published Abstract, 2019, DOI
• Jsun Loong Wong, Frieda Clinton, Maria Carroll, Andrea Malone, Aengus O'Marcaigh, Owen Patrick Smith, Jane Pears, Michael Capra, Cormac Owens, Incidence and 5 years survival rates of childhood cancer diagnosed less than 1 year old in Ireland 2007-2017, Archives of Disease in Childhood, Royal College of Paediatrics and Child Health, 9th Europaediatric Congress, Dublin, 13-15 June 2019, 104, (Suppl 3), 2019, ppA349-Published Abstract, 2019, DOI
• S Alken, C Gilham, M Capra, C Grant, J Pears, S Deady, O'Mahony D, Walsh P, Owens C, Survival of paediatric and adolescent/young adult (AYA) cancer patients with sarcoma in Ireland during 1994-2014: comparisons by age, Archives of Disease in Childhood, Royal College of Paediatrics and Child Health, 9th Europaediatric Congress, Dublin, 13-15 June 2019, 104, (Suppl 3), 2019, ppA348-Published Abstract, 2019, DOI
• S Burrington, L Darcy, T McVeigh, M Capra, Cancer predisposition screening in children with cancer in ireland, Archives of Disease in Childhood, Royal College of Paediatrics and Child Health, 9th Europaediatric Congress, Dublin, 13-15 June 2019, 104, (Suppl 3), 2019, ppA348 - A349Published Abstract, 2019, DOI
• A Stanzelova, M Connell, J Pears, M Capra, A Malone, Smith O, O'Marcaigh A, Owens C, Golden Hour: Audit on Timely Administration of Antibiotics in Haemato-Oncologic Patients Presenting with Febrile Neutropenia, Pediatric Blood and Cancer, SIOP, Kyoto, Japan, 16-19 Nov 2018, 65, 2018, ppS545-Published Abstract, 2018, DOI
• F Clinton, C Thompson, A Stanzelova, K Gavin, J Pears, C Owens, M Capra, Survival Following High Dose Chemotherapy for Infant Medulloblastoma/PNET in Ireland, Pediatric Blood and Cancer, SIOP, Kyoto, Japan, 16-19 Nov 2018, 65, 2018, ppS429 - S430Published Abstract, 2018, DOI
• Y Suehara, T Trahair, M Kirby, S Saito, M Capra, T Ghosh, M Cox, N Ku, D Henry, S Kato, D Zeigler, Expanded access of larotrectinib to manage pediatric trk fusion sarcomas, Pediatric Blood and Cancer, SIOP, Kyoto, Japan, 22-24 Nov 2019, 65, 2018, ppS335 - S336Published Abstract, 2018, DOI
• M Beirne, M O'Brien, E Smyth, E Butler, M Capra, Malone A, Owens C, Pears J, Smith O, O'Marcaigh A, Fitzpatrick M, Monitoring defibrotide usage in paediatric patients undergoing HSCT with known risk factors for developing VOD/SOS, Bone Marrow Transplantation, European Society for Blood and Marrow Transplantation, 44th Annual Meeting, Lisbon, Portugal, 18-21 March, 53, 2018, pp876 - 877Published Abstract, 2018, DOI
• O Quigley, J Garland, T Slevin, C Buckley, F O'Loughlin, S Broderick, C Owens, M Capra, Information Leaflet on the Completion of Chemotherapy and Transfering to the Out-Patient Follow-Up Clinics, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS217-Published Abstract, 2016, DOI
• N Cullinan, D Webb, C Owens, M Capra, J Pears, J McHugh, Reversible Motor Neuropathy with Conduction Block in a Child Receiving Vincristine, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS277-Published Abstract, 2016, DOI
• K Lee, C O'Sullivan, P Daly, J Pears, C Owens, M Capra, Proton Therapy in Irish Paediatric Oncology-A Review of Toxicities, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS135Published Abstract, 2016, DOI
• C Carroll, A Smith, F Clinton, A Ryan, M Capra, J Pears, C Owens, The Impact of Improving Nutrition During Induction Chemotherapy in Children with High-Risk Neuroblastoma, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS288Published Abstract, 2016, DOI
• N Cullinan, A Ryan, J Caird, D Crimmins, M Capra, J Pears, C Owens, Paediatric Low Grade Glioma with Complete vs Incomplete Resection, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS131Published Abstract, 2016, DOI
• N Cullinan, C O'Sullivan, P Daly, J Pears, C Owens, F Clinton, M Capra, Timing to Radiotherapy in an Irish Cohort of Patients with Medulloblastoma/PNET, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS131Published Abstract, 2016, DOI
• P Brock, M Childs, K Rajput, R Maibach, L Brugieres, D Roebuck, M Sullivan, V Laithier, M Rhonge, dall'Igna, P., E Hiyama, B Brichard, J Skeen, ME Mateos, M Capra, M Fabre, G Perilongo, P Czauderna, B Morland, E Neuwelt, Two Year Results of a Randomised Phase III Trial for Standard Risk Hepatoblastoma (SR-HB) SIOPEL 6; Cisplatin and Sodium Thiosulfate (STS) Vs Cisplatin Alone, Pediatric Blood and Cancer, SIOP, Dublin, 16-19 Oct 2016, 63, (S3), 2016, ppS33Oral Presentation, 2016, DOI
• T Prendiville, A Deery, C Owens, J Pears, M Capra, L Walsh, K Warciak, Reduction in left ventricular myocardial function in long-term paediatric neuroblastoma survivors, Heart, Irish Cardiac Society Annual Scientific Meeting, Kilkenny, Ireland, 8th Oct 2016, 102, (Suppl 9), 2016, ppA10Published Abstract, 2016, DOI
• M Javadpour, S Giva, C Costigan, J Caird, D Crimmins, M Capra, J Pears, C Owens, D Brosnahan, C O'Sullivan, D Cody, Early Outcomes of Endoscopic Extended Transsphenoidal Surgery for Craniopharyngiomas in Children , Neuro-Oncology, ISPNO 2016, Liverpool, UK, 12-17 June 2016, 18, (Suppl 3), 2016, ppii22-ii23Published Abstract, 2016, DOI
• N Cullinan, J Cryan, C O'Sullivan, P Daly, M Farrell, M Capra, J Pears, C Owens , RADIATION-INDUCED GLIOBLASTOMA MULTIFORME WITHIN 4 YEARS OF CRANIAL IRRADIATION FOR PAEDIATRIC CRANIOPHARYNGIOMA-CASE REPORT AND REVIEW OF THE LITERATURE, Neuro-Oncology, ISPNO 2016, Liverpool, UK, 13-15 June 2016, 18, (Suppl 3), 2016, ppiii20-iii21Published Abstract, 2016, DOI
• N Comey, P Lynam, O Smith, C Owens, M Capra, Pears J, O'Marcaigh A, Haematopoietic Progenitor Cell Collections Using the Spectra Optia (R) MNC Protocol (v. 11) on patients< 12.5 kgs., Bone Marrow Transplantation, EBMT 42nd Annual Meeting, Valencia, Spain, 51, 2016, ppS340-S341Published Abstract, 2016, DOI
• Penelope Rachel Brock, Rudolf Maibach, Margaret Childs, Kaukab Rajput, Edward A Neuwelt, Derek Roebuck, Michael James Sullivan, Veronique Laithier, Milind Ronghe, Liane Lockwood, Patrizia dall'Igna, Eiso Hiyama, Benedicte Brichard, Jane Skeen, Maria Elena Mateos, Monique Fabre, Arun Atreiya Rangaswami, Michael Capra, Piotr Czauderna, Bruce Morland, Anti-tumor efficacy in SIOPEL 6: A multi-centre open label randomised phase III trial of the efficacy of sodium thiosulphate (STS) in reducing ototoxicity in patients receiving cisplatin (Cis) monotherapy for standard risk hepatoblastoma (SR-HB), Journal of Clinical Oncology, ASCO, Chicago, USA, 29 May-2 Jun 2015, 33, (15_suppl), 2015, pp10039Published Abstract, 2015, URL
• Loughnane P, Clinton F, Capra M, Feasibility of a New Screening Tool to Optimise the Management of Patients with Chemotherapy Induced Peripheral Neuropathy (CIPN), Pediatric Blood and Cancer, SIOP, Toronto, Canada, 22-25th Oct 2014, 61, (S2), 2014, ppS239-S240Published Abstract, 2014, URL
• J Zsiros, P Brock, L Brugieres, D Roebuck, Zimmerman A, Maibach R, Childs M, Rangaswamie A, Casanove M, Pariente D, Sullivan M, Laithier V, Ronghe M, Capra M, Otte JB, Fabre M, Plaschkes J, Perilongo G, Czauderna P , High cure rate in high risk hepatoblastoma with dose intensive cisplatin based chemotherapy-results of the SIOPEL4 trial, Pediatric Blood and Cancer, SIOP, Boston, USA, 21-24 Oct 2010, 55, (5), 2010, pp816Oral Presentation, 2010, DOI
• Maibach R, Roebuck D, Brock P, Lathier V, Zsiros J, Zimmerman A, Capra M, Childs M, Perilongo G, Plaschkes J, Czauderna P, Shafford E, Aronson D, Otte JB, de Camargo B, Scopinaro M, Brugieres L, Clinical prognostic factors in hepatoblastomas: The SIOPEL experience, Pediatric Blood and Cancer, SIOP, Boston, USA, 21-24 Oct 2010, 55, (5), 2010, pp813 - 814Oral Presentation, 2010, DOI
• S Curry, F Ibrahim, M Corbally, M Capra, MB McDermott, D Betts, MJ O'Sullivan,, Renal Cell Carcinoma as an Early Secondary Malignancy Post-Embryonal Rhabdomyosarcoma - Implications for the Role of TP53., Pediatric and Developmental Pathology, Society for Pediatric Pathology/Paediatric Pathology Society Combined Fall Meeting, Philadelphia, Oct 2009, 13, (2), 2010, pp154 - 155Published Abstract, 2010, DOI , URL
• Sullivan M, Childs M, Capra M, Clinical features and outcome of patients with Becwith-Weidemann syndrome and hepatoblastoma treated on SIOPEL 2 and 3 clinical trials, Pediatric Blood and Cancer, SIOP, Mumbai, India, 30 Oct-3 Nov 2007, 49, (4), 2007, pp458Published Abstract, 2007, DOI
• Grant RM, Capra M, Gerstle T, Weitzman S, Response to therapy in a patient with coexisting Langerhans cell histiocytosis (LCH) and neuroblastoma emphasizes the need for the addition of LCH-directed therapy, Pediatric Blood and Cancer, Histiocyte Society XIX Annual Meeting, Philadelphia, USA, 18-20 Sept 2003, 43, (2), 2004, pp204Published Abstract, 2004, DOI
• J Volpe, M Steele, AM Maloney, M Capra, Survey of deaths in a large Canadian pediatric hematology/oncology division, Journal of Palliative Care, 15th International Conference on Care of the Terminally Ill, Montreal, Canada, 19-23 Sept 2004, 20, (3), 2004, pp258Published Abstract, 2004, DOI
• Sivaprakasam P, Gupta A, Greenberg M, Capra M, Nathan P. , Survival and Cardiac Outcomes in Children with Hepatoblastoma (HB) Treated with Continuous Infusion Cisplatin and Doxorubicin, Pediatric Blood and Cancer, SIOP, Sao Paulo, Brazil, 5-9 Oct 2009, 53, (5), 2009, pp745 - 746Oral Presentation, 2009, DOI
• N Al-Faris, M Capra, P Babyn, A Pappo, R Grant , Translocation t(1;13)(p36;q14) positive alveolar rhabdomyosarcoma with bone marrow and CSF metastases: a case report and review of the literature, American Society of Pediatric Hematology/Oncology 19th Annual Meeting, San Francisco, USA, Apr 29-May 2 2006, 46, (6), 2006, pp703Published Abstract, 2006, DOI
• Grant R, Pope E, Malkin D, Capra M, Babyn P, Thorner P, Rapid progression and dissemination of interdigitating dendritic cell sarcoma (IDCS) during intensive combination therapy, Pediatric Blood and Cancer, Histiocyte Society 20th Annual Meeting, Stockholm, Sweden, 12-14 Sept 2004, 45, (1), 2005, pp97Published Abstract, 2005, DOI
• Atra A, Higgs E, Capra M, Elsworth A, Imeson J, Radford M, Hewitt M, Stage IV Hodgkin's Disease (HD) in Children: Results of the United Kingdom Children's Cancer Study Group (UKCCSG), International Conference on Malignant Lymphoma, Lugano, Switzerland, 10, (Supp 3), 1999, pp26Oral Presentation, 1999, DOI
• Atra A, Capra M, Higgs E, Elsworth A, Imeson J, Pinkerton CR, Hewitt M, Radford M, Parenchymal Lung Involvement in Children with Advanced Hodgkin's Disease (HD), Annals of Oncology, International Conference on Malignant Lymphoma, Lugano, Switzerland, 2-5 June 1999, 10, (Supp 3), 1999, pp123Published Abstract, 1999, DOI
• Doz F, van Tilburg CM, Geoerger B, Højgaard M, Øra I, Boni V, Capra M, Chisholm J, Chung HC, DuBois SG, Gallego-Melcon S, Gerber NU, Goto H, Grilley-Olson JE, Hansford JR, Hong DS, Italiano A, Kang HJ, Nysom K, Thorwarth A, Stefanowicz J, Tahara M, Ziegler DS, Gavrilovic IT, Norenberg R, Dima L, De La Cuesta E, Laetsch TW, Drilon A, Perreault S. , Efficacy and safety of larotrectinib in TRK fusion-positive primary central nervous system tumors, Neuro Oncology, 24, (6), 2022, p997 - 1007Journal Article, 2022, DOI
• Besani C, Dunne A, D'Arcy-Bewick S, Owens C, Pears J, O'Marcaigh A, Malone A, Fortune G, Capra M, Smith OP., The Development of a National Paediatric Psycho-Oncology Service, Irish Medical Journal, 19, (7), 2021, p400-Journal Article, 2021
• Sébastien Perreault, François Doz, Birgit Geoerger, Karsten Nysom, Ingrid Øra, Valentina Boni, Julia Chisholm, Steven G DuBois, Nicolas U Gerber, Hiroaki Goto, Juneko E Grilley-Olson, Jordan R Hansford, Hyoung Jin Kang, Michael Capra, Johannes H Schulte, Joanna Stefanowicz, Makoto Tahara, David S Ziegler, Ricarda Norenberg, Laura Dima, Esther De La Cuesta, Theodore W Laetsch, Cornelis M van Tilburg, RARE-07. EFFICACY AND SAFETY OF LAROTRECTINIB IN PEDIATRIC PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION-POSITIVE PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS, Neuro-oncology, Society for Neuro-Oncology's 6th Biennial Pediatric Neuro-Oncology Basic and Translational Research Conference, Virtual, June 10-12, 2021, 23, (Supp 1), 2021, ppi42-Published Abstract, 2021, URL
• Brock P, Meijer A, Kogner P, Ansari M, Capra M, Geller J, Heuvel-Eibrink MVD, Knight K, Kruger M, Lindemulder S, Maibach R, O'Neill A, Papadakis V, Rajput K, Bleyer A, Bouffet E, Sullivan M., Sodium thiosulfate as cisplatin otoprotectant in children: The challenge of when to use it, Pediatr Blood Cancer, (Feb 11:e30248), 2023Journal Article, 2023, DOI
• Howley S, Stack D, Morris T, McDermott M, Capra M, Betts D, O'Sullivan MJ, Ectomesenchymoma with t(1;12)(p32;p13) evolving from embryonal rhabdomyosarcoma shows no rearrangement of ETV6., Human pathology, 43, (2), 2012, p299-302Journal Article, 2012, DOI , URL
• Rizkalla H, Wildgrove H, Quinn F, Capra M, O'Sullivan MJ, Congenital fibrosarcoma of the ileum: case report with molecular confirmation and literature review., Fetal and pediatric pathology, 30, (3), 2011, p156-60Journal Article, 2011, DOI
• Curry S, Ibrahim F, Grehan D, McDermott MB, Capra M, Betts D, O'Sullivan M., Rhabdomyosarcoma-associated renal cell carcinoma - A link with constitutional TP53 mutation. , Pediatr Dev Pathol. , 14, (3), 2010, p248 - 251Journal Article, 2010, DOI
• Nason GJ, Baker JF, Seoighe D, Irvine AD, McDermott M, Orr D, Capra M, Kelly PM, Congenital-infantile fibrosarcoma of the foot--avoidance of amputation., Irish medical journal, 107, (5), 2014, p148-9Journal Article, 2014, URL

• Strahm B, Capra M, Insights into the molecular basis of cancer development, Current Paediatrics, 15, (4), 2005, p333 - 338Journal Article
• Clinical Pharmacology and Toxicology in, editor(s)Beattie RM, Champion M , MRCPCH 1: Essential Questions in Paediatrics, 2nd Edition, London, PasTest td, 2009, pp26 - 36, [Tomlin S, Capra M]Book Chapter
• Haematology and Oncology in, MRCPCH 1: Essential Questions in Paediatrics, 2nd Edition, London, PasTest Ltd, 2009, pp117 - 128, [Capra M]Book Chapter
• Haematology and Oncology in, editor(s)Beattie M, Champion M , Essential Revision Notes n Paediatrics for the MRCPCH, 2nd Edition, London, PasTest Ltd, 2006, pp379 - 426, [Capra M]Book Chapter
• Clinical Pharmacology and Toxicology in, editor(s)Beattie RM, Champion M , Essential Revision Notes n Paediatrics for the MRCPCH, 2nd Edition, London, PasTest Ltd, 2006, pp143 - 162, [Tomlin S, Capra M]Book Chapter
• Clinical Pharmacology and Toxicology in, editor(s)Beattie RM, Champion M , Essential Questions in Paediatrics for MRCPCH Part 1, London, PasTest Ltd, 2004, pp39 - 52, [Tomlin S, Capra M]Book Chapter
• Haematology and Oncology in, editor(s)Beattie MB, Champion M , Essential Questions in Paediatrics for MRCPCH Part 1, London, PasTest Ltd, 2004, pp147 - 166, [Capra M]Book Chapter
• Haematology and Oncology in, editor(s)Beattie RM, Champion M , Essential Revision Notes in Paediatrics for the MRCPCH, London, PasTest Ltd, 2002, pp379 - 426, [Capra, M]Book Chapter
• Clinical Pharmacology and Toxicology in, editor(s)Beattie RM, Champion M , Essential Revision Notes in Paediatrics for the MRCPCH, London, PasTest Ltd, 2002, pp143 - 162, [Tomlin S, Capra M]Book Chapter
• Wells L, Capra M, Self assessment questions, Current Paediatrics, 9, (2), 1999, p132 - 134Journal Article
• Wells L, Capra M, Self assessment questions, Current Paediatrics, 9, (4), 1999, p272 - 274Journal Article
• Capra M, Hewitt M, Brain Tumours in Childhood, Current Paediatrics, 8, (2), 1998, p88 - 91Journal Article
• Capra M, Orbital Rhabdomyosarcoma: adjuvant treatment - beneficence vs nonmaleficence, British Oculoplastic Surgery Society (BOPSS), Dublin, June 15th , 2018Invited Talk
• Capra M, Recents developments in Paediatric Neuro-Oncology, UpToSPAED, Johannesburg, South Africa, 20th June, 2019, Europa Organisation Africa (EOA)Invited Talk
• Capra M, The greatest comeback: compassion in medicine, UpToSPAED, Johannesburg, South Africa, 21st June, 2019, Europa Organisation Africa (EOA)Invited Talk
• Capra M, Retinoblastoma Survivorship, One retinoblastoma World Conference, Dublin, 17th Oct, 2016, World Eye Cancer HopeInvited Talk
• Capra M, Oncology and Palliative Care, 2nD International Children's Palliative Care Conference, Dublin, 23rd April, 2016, International Children's Palliative Care NetworkInvited Talk
• Capra M, Paediatric Neuro-Oncology - the last decade, Neurosurgery Symposium: Celebrating 10 years of Neurosurgery at Temple Street, Dublin, 26th Oct, 2018Invited Talk
• Capra M, Primary Bone Cancer - the collaboration, 7th Bone Cancer Research Trust, Patients and Supporters Conference, Leeds, UK, 22nd June, 2013, Bone Cancer Research TrustInvited Talk
• Capra M, Acute Care in Childhood Cancer, Irish Conference on Survivorship after Cancer during Childhood and Adolescence, Dublin, 26th Nov, 2011, Boyne Institute in partnership with PancaresurfupInvited Talk
• Capra M, Malignant Melanoma in Childhood, Irish Melanoma Forum, Dublin, 18th Nov, 2011, ICORGInvited Talk
• Capra M, Chemotherapy in Retinoblastoma, International Paediatric Ophthalmology Conference, Dublin, 9th Oct, 2009, Prof Michael O'KeeffeInvited Talk
• Capra M, Childhood Liver Tumours and Current Trials, Childhood Cancer and Leukaemia Group (CCLG) summer meeting, Dublin, 2nd July , 2007, CCLGInvited Talk
• Katherine Gavin, Frieda Clinton, Michael Capra, Childhood Cancer Survivorship Project. Assessment of the needs of childhood cancer survivors in Ireland, 2022: patient, parent/guardian/carer perspectives, HSE Print - National Children's Cancer Service, Children's Health Ireland (CHI) at Crumlin, December 2022, 2022, p1 - 48Report

• Title

  Children's Liver Tumour European Research Network - chiLTERN
  Summary

  ChiLTERN is a European-funded project under the Horizon 2020 programme. It is the single largest clinical trial ever undertaken amongst the paediatric population. With twenty-five beneficiaries over twelve European countries, ChiLTERN aims to cure more children with liver cancer, expose fewer children to toxic chemotherapy and ensure their surgery is both effective and safe. This project, with seven work packages (WP), addressing different aspects of the collaboration, has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668596. Hepatoblastoma (HB) is the main liver tumour occurring in childhood, generally arising in infants under 3 years of age. In contrast, hepatocellular carcinoma (HCC), the main liver tumour in adults, is much rarer in children. The outcome for HB patients has dramatically improved over the past 20 years due to the introduction of new chemotherapy regimens, combined with efficient surgical approaches. Accordingly, survival rates of paediatric patients with liver cancer have increased from 30% in the 1970s to about 75% nowadays. Nevertheless, there are still very limited treatment options for patients suffering from certain types of aggressive liver tumours because of their resistance to chemotherapy. Survivors can suffer serious side effects due to the high doses of chemotherapy administered to young children. Therefore, there is an urgent need to improve the knowledge of this rare cancer and discover new drugs and therapeutic targets to treat high-risk disease and reduce the severity of current chemotherapy-related side effects. The rarity of liver cancer in children makes it hard to run good clinical trials to identify the best treatments. Furthermore, the scientific community has had limited access to biological samples from patients and this has impaired our knowledge of the biology of the disease. Consequently, and in contrast to some other cancers, children with liver cancer have not benefited from the incorporation of biological data into medical practice, which might enable more reliably evidence-based treatments to become established as the standard of care. The core part of ChiLTERN is the Paediatric Hepatic International Tumour Trial (PHITT) (WP2) to which the consortium partners in Europe will contribute. Parallel trials are being run in USA and Japan, with all data being merged into a single database housed in Europe. The University of Birmingham is the trial's sponsor for European and the statistical analysis centre. The seven work packages are as follows: - WP1: data management plans, independent oversight committees - WP2: Pediatric Hepatic International Tumour Trial (PHITT) - WP3: collection and analysis of biological samples - WP4: validation of prognostic factors from previous trials (CHIC-HS) - WP5: establish surgical guidelines - liver resection and liver transplantation - WP6: identifying biological factors that determine drug-induced toxicities - WP7: communication and dissemination of results of chiLTERN
  Funding Agency

  European Union's Horizon 2020 - H2020-EU.3.1.3
  Date From

  1st Jan 2016
  Date To

  31st Dec 2021
• Title

  Palliative Chemotherapy Versus Supportive Care Alone for End-of-Life care in Pediatric Cancer: measuring parents' and healthcare professionals' preferences.
  Summary
  Funding Agency

  National Cancer Institute of Canada
  Date From

  2005
  Date To

  2008
• Title

  Irish Childhood Cancer Survivorship Project
  Summary

  Introduction . Survival rates are now approaching 80% for childhood cancers overall, however survivors of childhood cancer carry a substantial burden of morbidity and are at increased risk of premature death. . Early detection and intervention of side-effects/long term effects of disease and treatment may improve patient outcomes. . No population-based data exists on the numbers of childhood cancer survivors in Ireland or the incidence and range of direct cancer and/or cancer treatment-related effects experienced. . Transitioning from childhood cancer care to adult care is challenging for survivors. . The Department of Health's National Cancer Strategy 2017-2026 recognizes the increasing unmet service needs of survivors and is committed to addressing this deficiency. . Service planners and those delivering care to survivors are now challenged to develop and provide a world class comprehensive survivorship service informed by a robust research infrastructure. Aim The over-arching aim of this project is to facilitate the development of a national comprehensive survivorship service for all survivors of childhood cancer while at the same time establishing a longitudinal survivorship research infrastructure. Method Service development must be underpinned by accurate data on current service provision, deficits to care and future requirements. At present, no population-based data exists on the numbers of childhood cancer survivors in Ireland and the incidence and range of direct cancer and/or cancer treatment-related effects experienced. In addition, there is a paucity of data available on the challenges of transitioning to adult care and where, how and by whom this care is provided. There is limited data on the needs and perspectives of childhood, adolescent and young adult cancer patients, their parents/guardians and the professionals delivering that service. This lack of data is arguably the greatest limiting factor to the development of a world class national service in Ireland for this cohort of patients. A survivorship project team, led by Dr Michael Capra and Dr Katherine Gavin at CHI, has begun the critical first step in addressing this data deficit by collaborating with Trinity College Dublin to design an electronic Irish childhood cancer survivorship database. This in turn will help generate a Treatment Summary/Survivorship Passport which will be given to patients/survivors to facilitate their transition on graduation from paediatric to adult care. The aim is to have this survivorship passport electronically available to survivors as well as health care professionals through the proposed National Clinical Imaging System (NCIS) of the National Cancer Control Programme (NCCP). The database will provide an infrastructure to facilitate research in multiple areas pertaining to Irish childhood cancer survivors with the aim of delivering tailored patient centered-care, improved survival and quality of life. The project is now embarking on increasing the collaborative effort to include the Irish Cancer Society (ICS), to extend the collaboration with the NCCP, and to pursue active collaboration with the parent/pateint advocacy groups - Children's Cancer Foundation and CanCare4Living, relative to the mutual synergies and common aim of all parties.
  Funding Agency

  Children's Health Foundation
  Date From

  2018
  Date To

  ongoing
• Title

  Hope: The Complex Journey of Parents of Children with Cancer
  Summary

  Multidisciplinary project to document the trajectory and meaning of hope in parents with cancer
  Funding Agency

  Canadian Institute of Health Research, Brainchild
  Date From

  2005
  Date To

  2008
• Title

  Sibling and Parent Bereavement from Childhood Cancer.
  Summary

  Project to document the nature of bereavement amongst siblings and parents of children who died from cancer.
  Funding Agency

  National Cancer Institute of Canada
  Date From

  2005
  Date To

  2010
• Title

  smart Card Application improving canceR survivors quality of lifE - smartCARE
  Summary

  While cancer survival rates have increased significantly, cancer survivors still suffer from a wide range of issues, often significantly decrementing their quality of life. Beyond the need for health systems to address these issues, cancer survivors also deserve to receive relevant and adapted information to help them meet the challenges they face. Such information should cover all aspects of their cancer survivorship, including access to specialist care and support services addressing both physical and psycho-social impacts of cancer. In this respect, the smartCARE project aims at developing a Cancer Survivor Smart Card to improve the quality of life and health status of cancer survivors, in the form of a mobile application, embracing the core attributes of patient-centred care. smartCARE will run an extensive user"s need assessment to achieve the fullest understanding of the range of survivors, caregiver & healthcare professionals" needs associated to the development of a cancer Survivor Smart Card. In doing so, particular understanding will be gained in respect to paediatric and adult cancer survivor needs and the needs of cancer survivors with co-morbidities. smartCARE will conceptualise specifications and develop the overarching long-term vision of a Cancer Survivor Smart Card. In addition, smartCARE will run a technical proof of concept through the development and piloting of an application by defining an interoperable Smart Card solution usable across a variety of healthcare infrastructures and readily available to survivors and their families. The Smart Card will facilitate patient empowerment, allowing survivors to have an easy access to their treatment summary, being able to share it with relatives and professionals but also having access to a broad range of resources and functionalities enhancing quality of life. The application will comprise three main elements: treatment summary, resources functions & follow-up care plan and self-management tools.
  Funding Agency

  European Health and Digital Executive Agency
  Date From

  1 January 2023
  Date To

  31 December 2024

Oncology and cancer biology, Oncology and cancer biology,

• Junior Faculty Award for Clinical Excellence In Paediatric Care, The Hospital for Sick Children, Toronto 2006
• Paediatric Educational Resident Lecture Series Award, The Hospital for Sick Children, Toronto 2005
• Robert Salter Humanitarian Award, The Hospital for Sick Children, Toronto 2005
• Emergency Medicine Division - Best Grand Round Presentation, The Hospital for Sick Children 2005

• PanCare present
• Children's Oncology Group (COG) present
• The Society Of International Paediatric Oncology (SIOP) present
• The Council of Canadian Pediatric Hematology Oncology Directors (CCPHOD) 2006
• EURO EWING Consortium (EEC) present
• SIOP - Brain Tumour Group (SIOP-BTG) present
• Society of International Paediatric Epithelial Liver Tumours (SIOPEL) present
• SIOP Renal Tumour Study Group (SIOP-RTSG) present
• Fight Osteosarcoma Through European Research (FOSTER) present
• Pediatric Oncology Group of Ontario (POGO) 2006
• Children's Cancer and Leukaemia Group (CCLG) present
• National Cancer Control Programme (NCCP) present

• Principal Investigator - Children's Oncology Group: Our Lady's Children's Hospital, Crumlin 2010
• Member - National Cancer Control Programme (NCCP) Molecular Diagnostic Committee 2018
• Member - International Society of Paediatric Oncology (SIOP) Scientific Committee 2015
• Member - Paediatric Oncology Group of Ontario (POGO) - annual conference organising committee, 2004-2005 2004
• Rater - MORE (McMaster Online Rating of Evidence), Health Information Research Unit, McMaster University 2007
• Executive Committee and National Coordinator - FOSTER (Fight Osteosarcoma Through European Research) 2021
• Member - National Cancer Control Programme (NCCP) Molecular Diagnostic Committee 2018
• Rater - MORE (McMaster Online Rating of Evidence), Health Information Research Unit, McMaster University 2007
• Chair - local organising committee for the 48th Annual Society of International Paediatric Oncology (SIOP) conference in Dublin, Ireland Oct 2016
• Member - Paediatric Oncology Group of Ontario (POGO) - annual conference organising committee, 2004-2005 2004
• Member - International Society of Paediatric Oncology (SIOP) Scientific Committee 2015
• Chair - local organising committee for the 48th Annual Society of International Paediatric Oncology (SIOP) conference in Dublin, Ireland Oct 2016
• Chair - National Children's Cancer Programme (NCCP) Survivorship CAYA Subcommittee 2019
• Board of Directors - International Society of Paediatric Oncology (SIOP) 2015
• Board of Directors - International Society of Paediatric Oncology (SIOP) 2015
• Principal Investigator - Children's Oncology Group: Our Lady's Children's Hospital, Crumlin 2010
• Executive Committee and National Coordinator - FOSTER (Fight Osteosarcoma Through European Research) 2021
• Chair - National Children's Cancer Programme (NCCP) Survivorship CAYA Subcommittee 2019