Medicine

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Trinity Biomedical Sciences Institute
Trinity College
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Dr. Adam Dyer

Dr. Adam Dyer

Clinical Lecturer, Medical Gerontology


Biography

Adam Dyer is an ICAT fellow and SpR in Geriatric Medicine/GIM (2021-28). Adam graduated from Medicine (TCD) in 2017 and holds Masters degrees in Neuroscience (Intercalated MSc) and Medical Gerontology (Research MSc) in addition to a Postgraduate Certificate in Statistics. Adam has published over 60 journal papers and his translational immunology research focuses on exploring the impact of age and frailty on immune system variability and how this variability influences the pathogenesis and progression of age-related disease - in particular cognitive impairment and dementia due to alzheimer disease.

Publications and Further Research Outputs

  • Dyer AH, Nabeel S, Briggs R, O'Neill D, Kennelly SP, Cognitive assessment of older adults at the acute care interface: the informant history., Postgraduate medical journal, 2016Journal Article, 2016, DOI , URL
  • Dyer AH, Briggs R, Nabeel S, O'Neill D, Kennelly SP, The Abbreviated Mental Test 4 for cognitive screening of older adults presenting to the Emergency Department., European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 2016Journal Article, 2016, DOI , URL
  • Briggs R, Dyer A, Nabeel S, Collins R, Doherty J, Coughlan T, O'Neill D, Kennelly SP, Dementia in the Acute Hospital: The prevalence and clinical outcomes of acutely unwell patients with dementia., QJM : monthly journal of the Association of Physicians, 2016Journal Article, 2016, DOI , URL
  • Vahdatpour C, Dyer A.H, Tropea D, Insulin-like growth factor 1 and related compounds in the treatment of childhood-onset neurodevelopmental disorders, Frontiers in Neuroscience, 10, (SEP), 2016Journal Article, 2016, DOI , URL
  • Dyer A.H, Vahdatpour C, Sanfeliu A, Tropea D, The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity, Neuroscience, 325, 2016, p89 - 99Journal Article, 2016, DOI
  • Fallon A, Kilbane L, Briggs R, Dyer A, Nabeel S, McElwaine P, Collins DR, Coughlan T, O'Neill D, RyanD, Kennelly SP, Screening for frailty in older emergency department patients: The utility of the Survey of Health, Ageing and Retirement in Europe Frailty Instrument (SHARE-FI) , QJM, 2018Journal Article, 2018, DOI , URL
  • Dyer AH, Foley T, O'Shea B, Kennelly SP. , Cognitive assessment of older adults in general practice: the collateral history , Ir J Med Sci. , 2018Journal Article, 2018, DOI , URL
  • 1. C. Keogh, G. Pini, A. H. Dyer, S. Bigoni, P. DiMarco, I. Gemo,, R. Reilly, D. Tropea, Clinical and Genetic Rett Syndrome Variants are Defined by Stable Electrophysiological Profiles, BMC Pediatrics, 18, (1), 2018, p333 - 348Journal Article, 2018, DOI , TARA - Full Text
  • Dyer AH, Foley T, O'Shea B, Kennelly SP, Dementia Diagnosis and Referral in General Practice: A Representative Survey of Irish General Practitioners, 2018Journal Article, 2018, URL
  • Dyer AH, Briggs R, Mockler D, Gibney J, Kennelly SP, Non-Pharmacological Interventions for Cognition in Patients with Type 2 Diabetes Mellitus: A Systematic Review., Quarterly Journal Medicine, 2019Journal Article, 2019, DOI
  • Dyer A, Killane I, Bourke N, Woods C, Gibney J, O'Neill D, Reilly R, Kennelly S, Does Dual-Task Gait Speed Predict Cognitive Performance in Midlife Type 2 Diabetes? Baseline Results from the ENBIND Study, Age and Ageing, Irish Gerontoloppgical Society 67th Annual Scientific Meeting, Cork, 27-28 Sept 2019, 48, (Suppl 3), 2019, ppiii3-4Meeting Abstract, 2019, DOI
  • Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD Study Group., Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD., Journal of the American Medical Directors Association, 21, (2), 2020, p194-200Journal Article, 2020, DOI
  • Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group., Gait speed, cognition and falls in people living with mild-to-moderate Alzheimer disease: data from NILVAD., BMC geriatrics, 20, (1), 2020, p117Journal Article, 2020, DOI
  • L. Aljohmani (EuroSurg Collaborative member), Safety of Hospital Discharge Before Return of Bowel Function After Elective Colorectal Surgery, BRITISH JOURNAL OF SURGERY, 2020Journal Article, 2020
  • Liam Townsend, Adam H Dyer, Karen Jones, Jean Dunne, Rachel Kiersey, Fiona Gaffney, Laura O'Connor, Aoife Mooney, Deirdre Leavy, Katie Ridge, Catherine King, Fionnuala Cox, Kate O'Brien, Joanne Dowds, Jamie Sugrue, David Hopkins, Patricia Byrne, Tara Kingston, Cliona Ni Cheallaigh, Parthiban Nadarajan, Anne Marie McLaughlin, Nollaig M Bourke, Colm Bergin, Cliona O'Farrelly, Ciaran Bannan, Niall Conlon, Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection, PloS One, 2020Journal Article, 2020
  • Kennelly SP, Dyer AH, Noonan C, Kennelly SM, Martin A, O'Neill D, Fallon A, Asymptomatic carriage rates and case-fatality of SARS-CoV-2 infection in residents and staff in Irish nursing homes, Age and Ageing, 50, (1), 2021, p49 - 54Journal Article, 2021, DOI , URL
  • Dyer A, McKenna L, Gamage G, Bourke N, Killane I, Widdowson M, Woods C, Gibney J, Reilly R, O'Neill D, Kennelly S. , Cognitive performance in midlife type 2 diabetes: results from the ENBIND study, Diabetic Medicine, 2020Journal Article, 2020, DOI , URL
  • Dyer AH, McKenna L, Batten I, Jones K, Widdowson M, Dunne J, Conlon N, Reilly R, Woods CP, O'Neill D, Gibney J, Bourke NM, Kennelly SP., Peripheral Inflammation and Cognitive Performance in Middle-Aged Adults With and Without Type 2 Diabetes: Results From the ENBIND Study, Front. Aging Neurosci, 12, 2020Journal Article, 2020, DOI , URL
  • Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD StudyGroup, Sedative Load in Community-Dwelling Older Adults with Mild-Moderate Alzheimer's Disease: Longitudinal Relationships with Adverse Events, Delirium and Falls., Drugs & aging, 2020Journal Article, 2020, DOI
  • Dyer AH, Murphy C, Briggs R, Lawlor B, Kennelly SP, NILVAD Study Group, Antidepressant use and orthostatic hypotension in older adults living with mild-to-moderate Alzheimer disease., International journal of geriatric psychiatry, 2020Journal Article, 2020
  • Murphy C, Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group, Potentially inappropriate medication use in older adults with mild-moderate Alzheimer's disease: prevalence and associations with adverse events., Age and ageing, 2020Journal Article, 2020, DOI , TARA - Full Text
  • Floyd R, Dyer AH, Kennelly SP, Non-pharmacological interventions for cognitive impairment in women with breast cancer post-chemotherapy: A systematic review., Journal of geriatric oncology, 2020Journal Article, 2020
  • Dyer AH, Murphy C, Lawlor B, Kennelly SP, NILVAD Study Group"", Long-term proton-pump inhibitor use in older adults with mild-to-moderate Alzheimer's disease: Are there cognitive consequences?, European journal of internal medicine, 2020Journal Article, 2020
  • Dyer AH, Murphy C, Lawlor B, Kennelly SP, Study Group For The Nilvad, Social networks in mild-to-moderate Alzheimer disease: longitudinal relationships with dementia severity, cognitive function, and adverse events. , Aging & mental health, 2020Journal Article, 2020
  • Dyer AH, Lawlor B, Kennelly SP, NILVAD Study Group, Sexual dimorphism in the association of APOE "4 genotype with cognitive decline and dementia progression in mild-to-moderate Alzheimer disease., International journal of geriatric psychiatry, 2020Journal Article, 2020
  • Dyer AH, Murphy C, Segurado R, Lawlor B, Kennelly SP, NILVAD Study Group, Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease?, The journals of gerontology. Series A, Biological sciences and medical sciences, 2019Journal Article, 2019
  • Townsend L, Dowds J, O'Brien K, Sheill G, Dyer AH, O'Kelly B, Hynes JP, Mooney A, Dunne J, Ni Cheallaigh C, O'Farrelly C, Bourke NM, Conlon N, Martin-Loeches I, Bergin C, Nadarajan P, Bannan C., Persistent Poor Health Post-COVID-19 Is Not Associated with Respiratory Complications or Initial Disease Severity., Annals of the American Thoracic Society, 2021Journal Article, 2021, DOI
  • Liam Townsend, Adam H Dyer, Aifric Naughton, Rachel Kiersey, Dean Holden, Mary Gardiner, Joanne Dowds, Kate O'Brien, Ciaran Bannan, Parthiban Nadarajan, Jean Dunne, Ignacio Martin-Loeches, Padraic Fallon, Colm Bergin, Cliona O'Farrelly, Cliona Ni Cheallaigh, Nollaig Bourke, Niall Conlon, Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health, Frontiers In Immunology, 2021Journal Article, 2021
  • Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021Journal Article, 2021
  • Adam H Dyer, Eamon Laird, Leane Hoey, Catherine F Hughes, Helene McNulty, Mary Ward, JJ Strain, Anne Molloy, Conal Cunningham, Kevin McCarroll, Long-Term Anticholinergic, Benzodiazepine and Z-Drug Use in Community-Dwelling Older Adults: What is the impact on Cognitive and Neuropyschological Performance? , International Journal of Geriatric Psychiatry, 2021Journal Article, 2021, DOI
  • Geriatric Medicine Research Collaborative , Covid Collaborative , Carly Welch, Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study, Age and Ageing, 2021, p617-630Journal Article, 2021, DOI , TARA - Full Text
  • Liam Townsend, Adam H. Dyer, Patrick McCluskey, Kate O"Brien, Joanne Dowds, Eamon Laird, Ciaran Bannan, Nollaig M. Bourke, Cliona Ní Cheallaigh, Declan G. Byrne, Rose Anne Kenny, Investigating the Relationship between Vitamin D and Persistent Symptoms Following SARS-CoV-2 Infection, Nutrients, 13, (7), 2021, p2430Journal Article, 2021, DOI
  • Dyer AH, Briggs R, Laird E, Hoey L, Hughes CF, McNulty H, Ward M, Strain JJ, Molloy AM, Cunningham C, McCarroll K., Glycated Haemoglobin (HbA1c), Diabetes and Neuropsychological Performance in Community-Dwelling Older Adults, Diabetic Medicine, 2021Journal Article, 2021, DOI
  • Bastard, Paul, Gervais, Adrian, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina, Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G., Lagier, Jean-Christophe, Gentile, Stéphanie, Rosen, Lindsey B., Shaw, Elana, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis, Sene, Damien, Stepanian, Alain, Megarbane, Bruno, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R., Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa, Biondi, Andrea, Bonfanti, Paolo, Castagnoli, Riccardo, Delmonte, Ottavia M., Zhang, Yu, Snow, Andrew L., Holland, Steven M., Biggs, Catherine, Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M., Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L., Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A., El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina, Metz, Christine N., Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A., Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G., Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y., Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C., Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H., Kennelly, Sean P., Bourke, Nollaig M., Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C., Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bonradenko, Anastasiia, Spaan, András N., Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P., Mane, Shrikant, Anderson, Mark S., Boisson, Bertrand, Béziat, Vivien, Zhang, Shen-Ying, Vandreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H., Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier, Vasse, Marc, Gregersen, Peter K., Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D., Su, Helen C., Kisand, Kai, Okada, Satoshi, Puel, Anne, Jouanguy, Emmanuelle, Rice, Charles M., Tiberghien, Pierre, Zhang, Qian, Cobat, Aurélie, Abel, Laurent, Casanova, Jean-Laurent, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths, Science Immunology, 6, (62), 2021, peabl4340Journal Article, 2021, DOI
  • Townsend L, Dyer AH, Naughton A, Imangaliyev S, Dunne J, Kiersey R, Holden D, Mooney A, Leavy D, Ridge K, Sugrue J, Aldoseri M, Kelliher JH, Ní Cheallaigh C, Severe COVID-19 is characterised by inflammation and immature myeloid cells early in disease progression, Heliyon, 8, (4), 2022, pe09230 - e09236Journal Article, 2022
  • Dyer AH, Noonan C, McElheron M, Batten I, Reddy C, Connolly E, Pierpoint R, Murray C, Leonard A, Higgins C, Reilly P, Boran G, Phelan T, McCormack W, O'Neill D, Fallon A, Brady G, O'Farrelly C, Bourke NM, Kennelly SP., Previous SARS-CoV-2 Infection, Age, and Frailty Are Associated With 6-Month Vaccine-Induced Anti-Spike Antibody Titer in Nursing Home Residents, Journal of the American Medical Directors Association, 2022Journal Article, 2022, DOI , URL
  • Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022Journal Article, 2022, DOI
  • Pini G, Congiu L, Benincasa A, DiMarco P, Bigoni S, Dyer AH, Mortimer N, Della-Chiesa A, O'Leary S, McNamara R, Mitchell KJ, Gill M, Tropea D., Illness Severity, Social and Cognitive Ability, and EEG Analysis of Ten Patients with Rett Syndrome Treated with Mecasermin (Recombinant Human IGF-1)., Autism research and treatment, 2016, 2016, p5073078Journal Article, 2016, DOI
  • Dyer AH, Ryan D, O'Callaghan S., 'Acopia' and 'inability to cope' remain unhelpful and pejorative labels for complexity in older adults presenting to the acute hospital., Age and ageing, 47, (3), 2018, p488Journal Article, 2018, DOI
  • EuroSurg Collaborative., Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery., The British journal of surgery, 107, (2), 2020, pe161-e169Journal Article, 2020, DOI
  • STARSurg Collaborative and EuroSurg Collaborative., Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery. , BJS Open, 6, (1), 2022, pzrab150Journal Article, 2022, DOI
  • Dyer AH, Murphy C, Lawlor B, Kennelly SP, For The Nilvad Study Group., Long-term antipsychotic use and cognitive decline in community-dwelling older adults with mild-moderate Alzheimer disease: Data from NILVAD., International journal of geriatric psychiatry, 36, (11), 2021, p1708-1721Journal Article, 2021, DOI
  • EuroSurg Collaborative., Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study., Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 22, (12), 2020, p2288-2297Journal Article, 2020, DOI
  • Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Leung D, Coulongeat M, Marlet J, Koning R, Reyes LF, Chauvineau-Grenier A, Venet F, Monneret G, Nussenzweig MC, Arrestier R, Boudhabhay I, Baris-Feldman H, Hagin D, Wauters J, Meyts I, Dyer AH, Kennelly SP, Bourke NM, Halwani R, Sharif-Askari FS, Dorgham K, Sallette J, Sedkaoui SM, AlKhater S, Rigo-Bonnin R, Morandeira F, Roussel L, Vinh DC, Erikstrup C, Condino-Neto A, Prando C, Bondarenko A, Spaan AN, Gilardin L, Fellay J, Lyonnet S, Bilguvar K, Lifton RP, Mane S, HGID Lab, COVID Clinicians, COVID-STORM Clinicians, NIAID Immune Response to COVID Group, NH-COVAIR Study Group, Danish CHGE, Danish Blood Donor Study, St. James's Hospital, SARS CoV2 Interest Group, French COVID Cohort Study Group, Imagine COVID-Group, Milieu Intérieur Consortium, CoV-Contact Cohort, Amsterdam UMC Covid-19 Biobank Investigators, COVID Human Genetic Effort, CP-COVID-19 Group, CONSTANCES cohort, 3C-Dijon Study, Cerba Health-Care, Etablissement Français du Sang Study group, Anderson MS, Boisson B, Béziat V, Zhang SY, Andreakos E, Hermine O, Pujol A, Peterson P, Mogensen TH, Rowen L, Mond J, Debette S, de Lamballerie X, Burdet C, Bouadma L, Zins M, Soler-Palacin P, Colobran R, Gorochov G, Solanich X, Susen S, Martinez-Picado J, Raoult D, Vasse M, Gregersen PK, Piemonti L, Rodríguez-Gallego C, Notarangelo LD, Su HC, Kisand K, Okada S, Puel A, Jouanguy E, Rice CM, Tiberghien P, Zhang Q, Casanova JL, Abel L, Cobat A., The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies., Proceedings of the National Academy of Sciences of the United States of America, 119, (21), 2022, pe2200413119Journal Article, 2022, DOI
  • Dyer AH, Laird E, Hoey L, Hughes CF, McNulty H, Ward M, Strain JJ, O'Kane M, Tracey F, Molloy AM, Cunningham C, Sexton DJ, McCarroll K, Reduced kidney function is associated with poorer domain-specific cognitive performance in community-dwelling older adults, International Journal of Geriatric Psychiatry, 2022Journal Article, 2022, DOI
  • Dyer AH, Fallon A, Noonan C, Dolphin H, O'Farrelly C, Bourke NM, O'Neill D, Kennelly SP, Managing The Impact Of COVID-19 in Nursing Homes and Long-Term Care Facilities: An Update, Journal of the American Medical Directors Association, 2022Journal Article, 2022
  • Garcia L, Woudenberg T, Rosado J, Dyer AH, Donnadieu F, Planas D, Bruel T, Schwartz O, Prazuck T, Velay A, Fafi-Kremer S, Batten I, Reddy C, Connolly E, McElheron M, Kennelly SP, Bourke NM, White MT, Pelleau S, Kinetics of the SARS-CoV-2 Antibody Avidity Response Following Infection and Vaccination, Viruses, 2022Journal Article, 2022, DOI
  • Herings PMR, Dyer AH, Kennelly SP, Reid S, Killane I, McKenna L, Bourke NM, Woods CP, O'Neill D, Gibney J, Reilly RB, Gait Characteristics and Cognitive Function in Middle-Aged Adults with and without Type 2 Diabetes Mellitus: Data from ENBIND, Sensors, 2022Journal Article, 2022, DOI
  • A Dyer, L Townsend, A Naughton, R Kiersey, D Holden, M Gardiner, J Dunne, C O'Farrelly, C N Cheallaigh, N Conlon, and N Bourke, EXPLORING THE IMPACT OF AGE AND FRAILTY STATUS ON THE IMMUNE RESPONSE TO COVID-19 ILLNESS USING DETAILED IMMUNO-PHENOTYPING, Irish Gerontological Society Annual Meeting, 18th November 2021, 2021Oral Presentation, 2021
  • Adam Dyer, Isabella Batten, Isabelle Killane,Conor Woods, James Gibney, Desmond O'Neill, Richard Reilly, Nollaig Bourke, Sean Kennelly, LINKING DIABETES AND DEMENTIA RISK:A ROLE FOR Aβ-42 INDUCED ACTIVATION OF THE NLRP3 INFLAMMASOME? RESULTS FROM THE ENBIND STUDY, Irish Endocrine Society Annual Scientific Meeting, Galway, 2019Oral Presentation, 2019
  • Adam Dyer, Robert Briggs, Sean Kennelly, What are the Effects of Lifestyle Interventions for Type II Diabetes Mellitus on Cognition ? A Systematic Review, Royal Academy of Medicine in Ireland Section of Interns Study Day, Dublin, January 2018, 2018Oral Presentation, 2018
  • Adam Dyer, Shamis Nabeel, Robert Briggs, Desmond O'Neill, Sean Kennelly, Investigating Cognitive Impairment in the Emergency Department: The Role of the Informant History, Irish Gerontological Society Annual Scientific Meeting, Killarney, September 2016, 2016Oral Presentation, 2016
  • P Claffey, L Pérez-Denia, A Dyer, T McNicholas, R Briggs, C Finucane, R A Kenny, Is Orthostatic Hypotension Associated with Altered Cerebral Perfusion During Active Standing , Irish Gerontological Society Annual Scientific Meeting, 2021Oral Presentation, 2021
  • Claire Murphy, Adam H Dyer, Brian Lawlor, Sean P Kennelly, Potentially Inappropriate Medications in Patients with Alzheimer's Disease: Data from NILVAD, Irish Gerontological Society Annual Scientific Meeting, Cork, 2019Oral Presentation, 2019
  • A Dyer; C Noonan; R Pierpoint; A Leonard; G Boran; G Brady; A Fallon; Cliona O'Farrelly; N Bourke; S Kennelly, Previous SARS-CoV2 Infection, Age and Frailty Predict 6-Month BNT162b Vaccine-Induced Antibody Titre in Nursing Home Residents: Data from NH-COVAIR, British Geriatrics Society Spring Meeting, London, April 2022, 2022Oral Presentation, 2022
  • Adam Dyer, Claire Noonan , Matt McElheron , Isabella Batten , Conor Reddy , Emma Connolly , Rachel Pierpoint , Caroline Murray , Ann Leonard, Gerard Boran , Cliona O'Farrelly , Thomas Phelan , Aoife Fallon , Gareth Brady , Nollaig Bourke , Sean Kennelly, Declining antibody response to SARS-CoV-2 at 6 months following vaccination in nursing home residents: data from NHCOVAIR, European Union Geriatric Medicine Society, Athens, Greece, September 2021, 2021Oral Presentation, 2021
  • Adam Dyer, Isabella Batten, Liam Townsend, James Gibney, Conor Woods, Nollaig M Bourke, Sean P Kennelly, Common Pathological Pathways Between Type 2 Diabetes and Dementia: Investigating the Role of the Innate Immune System, British Neuroscience Association Festival of Neuroscience, Dublin, 2019Oral Presentation, 2019
  • Dyer AH, Batten I, Reddy C, Townsend L, Woods CP, O'Neill D, Gibney J, Kennelly SP, Bourke NM, Neuropsychological Decrements in Midlife Type-2 Diabetes are Not Associated with Peripheral NLRP3 Inflammasome Responsiveness, Frontiers in Immunology, 2022Journal Article, 2022, DOI , URL
  • Heike C. Hawerkamp, Adam H. Dyer, Neha D. Patil, Matt McElheron, Niamh O'dowd, Laura O'doherty, Aisling Ui Mhaonaigh, Angel M. George, Aisling M. O'halloran, Conor Reddy, Rose Anne Kenny, Mark A. Little, Ignacio Martin-Loeches, Colm J. Bergin, Sean Kennelly, Seamas C. Donnelly, Nollaig Bourke, Aideen Long, Jacklyn Sui, Derek G. Doherty, Niall Conlon, Cliona Ni Cheallaigh and Padraic Fallon, Characterisation of the Pro-Inflammatory Cytokine Signature in Severe COVID-19, Frontiers in Immunology , 2023Journal Article, 2023
  • Murphy C, Dyer AH, Lawlor B, Kennelly SP, for the NILVAD study group, What is the impact of ongoing statin use on cognitive decline and dementia progression in older adults with mild-moderate Alzheimer disease?, PLoS ONE, 2023Journal Article, 2023, DOI
  • Dolphin H, Dyer AH, McHale C, O'Dowd S, Kennelly SP, An Update on Apathy in Alzheimer's Disease, Geriatrics (Basel), 2023Journal Article, 2023, DOI
  • Dolphin H, Dyer AH, Dukelow T, Finucane C, Commins S, Kennelly SP, Safety and Feasibility of Transcutaneous Vagus Nerve Stimulation in Mild Cognitive Impairment: VINCI-AD Study Protocol, BMC Neurology, 2023Journal Article, 2023
  • Dyer AH, Dolphin H, Welsh T, Soysal P, Roitto HM, Religa D, Kennelly SP, EuGMS Special Interest Group in Dementia, Emerging Disease Modifying Therapies for Older Adults with Alzheimer Disease: Perspectives from the EuGMS Special Interest Group in Dementia, EUROPEAN GERIATRIC MEDICINE, 2023Journal Article, 2023
  • Gordon Greville, Sinead Cremen, Shauna O'Neill, Sarah Azarian, Gareth Brady, William McCormack, Adam H Dyer, Nollaig M Bourke, Olivier Touzelet, David Courtney, Ultan F Power, Paul Dowling, Tom K Gallagher, Connor G G Bamford, Mark W Robinson, Type 1 interferon auto-antibodies are elevated in patients with decompensated liver cirrhosis, Clin Exp Immunol ., 2023Journal Article, 2023
  • Adam. H Dyer, Helena Dolphin, Matt McElheron, Nollaig M Bourke, Sean P Kennelly, Moving from "Vulnerability" to "Variability" in Defining a Place for the Biology of Aging in Geriatric Medicine. , European Geriatric Medicine, 2023Journal Article, 2023
  • Adam H Dyer, Helene McNulty, Aoife Caffrey, Shane Gordon, Eamon Laird, Leane Hoey, Catherine F Hughes, Mary Ward, J J Strain, Maurice O'Kane, Fergal Tracey, Anne M Molloy, Conal Cunningham, Kevin McCarroll, Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study, Neurobiol Aging, 2024Journal Article, 2024
  • Adam H Dyer, Helena Dolphin, Antoinette O'Connor, Laura Morrison, Gavin Sedgwick, Aoife McFeely, Emily Killeen, Conal Gallagher, Naomi Davey, Eimear Connolly, Shane Lyons, Conor Young, Christine Gaffney, Ruth Ennis, Cathy McHale, Jasmine Joseph, Graham Knight, Emmet Kelly, Cliona O'Farrelly, Nollaig M Bourke, Aoife Fallon, Sean O'Dowd, Sean P Kennelly, Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration, BMJ Open, 2023Journal Article, 2023, DOI
  • Adam H Dyer, Claire Murphy, Helena Dolphin, Laura Morrison, Robert Briggs, Brian Lawlor, Sean P Kennelly; NILVAD Study Group, Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease, European Geriatric Medicine, 2024Journal Article, 2024, DOI
  • Helena Dolphin, Adam H Dyer, Laura Morrison, Susan D Shenkin, Tomas Welsh, Sean P Kennelly, New horizons in the diagnosis and management of Alzheimer"s Disease in older adults, Age and Ageing, 53, (2), 2024Journal Article, 2024, DOI
  • Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny, The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand, The Journals of Gerontology: Series A, 2024Journal Article, 2024, DOI
  • Midlife Diabetes and the Risk of Dementia: Understanding the Link in, editor(s)Colin R. Martin, Victor R. Preedy , The Neuroscience of Dementia, Elsevier, 2020, [Sean Kennelly, Adam H Dyer]Book Chapter
  • R Penfold, AH Dyer, Editor's View: June 2023, AGE AND AGEING, 2023Journal Article

Research Expertise

  • Title
    Translating Inflammatory Biomarkers to Predict Disease Progression and Adverse Events in Mild-Moderate Alzheimer Disease (TIDE-AD)
    Summary
    Will examine the ability of systemic inflammatory biomarkers to predict clinical progression and adverse events over 18 months in older adults with mild-moderate Alzheimer Disease. TIDE-AD will also examine the impact of systemic inflammatory events to result in persistent immune dysregulation in older adults with mild-moderate Alzheimer Disease by assessing over 1,000 individual plasma and CSF samples from older 534 older adults with subjective memory complaints, mild cognitive impairment due to Alzheimer Disease and mild-moderate dementia due to Alzheimer Disease
    Funding Agency
    Meath Foundation
    Date From
    2021
    Date To
    2023
  • Title
    Investigating the Impact of Age and Frailty on Innate Immune Responses (FRAIL-INNATE
    Summary
    Explores innate Anti-Viral immune responses in older adults living with frailty; examines how increasing frailty states are associated with alterations in innate immune responses to various agonists using whole blood immunomonitoring; recruitment based in St James's Hospital & Tallaght University Hospital
    Funding Agency
    TCD & TTMI Building Engagements in Health Research
    Date From
    2021
    Date To
    2023
  • Title
    COVID-19 in Nursing Home Residents: Predicting Disease Severity, Outcomes and Antiviral Immune Responses (NH-COVAIR & NH-IMMUNE Studies)
    Summary
    Examines anti-viral immune responses in older nursing home residents including in vitro (PBMC stimulations in lab) and in vivo (SARS-CoV2 vaccine) responses. In addition to advancing understanding of the pathogenesis of viral infection in severely frail older adults, these insights offer to inform vaccine development/deployment strategies; biological sampling completed at baseline, 5 weeks & 6 months post-vaccine
    Funding Agency
    Meath Foundation
    Date From
    2020
    Date To
    2025
  • Title
    Exploring Novel Biomarkers of Brain Health in Diabetes (ENBIND)
    Summary
    Explores the relationship of novel bioengineering (e.g spatiotemporal gait analysis) and immunology (e.g circulating pro-inflammatory cytokines, peripheral blood immune cell responses to pathogenic amyloid ß-42) markers with cognitive function in midlife type 2 diabetes. Wave 1 (N = 150) completed; Wave 2 currently underway 2022-24 (ENBIND-II) seeking to examine the relationship between these markers and longitudinal cognitive trajectories in middle-aged adults with type 2 diabetes
    Funding Agency
    Meath Foundation
    Date From
    2019
    Date To
    2024
  • Title
    Defining the Role of Viral Infections in Early Alzheimer Disease (DRIVE-AD)
    Summary
    Alzheimer Disease (AD) affects 60,000 individuals in Ireland and is characterised by remarkable variation in clinical presentation and disease outcomes. There is an urgent need to understand the biological determinants of this variability so personalised approaches for AD prevention and treatment can be developed. Despite strong circumstantial evidence over the past two decades that viral infections (influenza, herpesviruses, viral pneumonia) increase AD risk, definitive real-world evidence is lacking. DRIVE-AD will deploy a high-throughput, low-cost assay to determine prior exposure to 50 common viral infections " several previously implicated in AD. DRIVE-AD aims to provide the first large-scale definitive evidence linking viral exposures to AD in humans to inform potential vaccination and anti-viral treatment strategies in older adults at risk of, or living with Alzheimer Disease
    Funding Agency
    Meath Foundation; Dean's Research Initiative
    Date From
    January 2024
    Date To
    July 2025

Recognition

  • Mary Ward Prize in Traffic Medicine 2015
  • John Purser Medal in Physiology and Biochemistry 2012
  • Connolly Norman Medal in Mental Disease (TCD) 2017
  • President's Prize, Irish Gerontological Society 2019
  • John Fleetwood Medal in Gerontology 2016
  • O'Morain Research Medal & Bursary (TUH) 2022
  • William Fearon Medal in Biochemistry 2013
  • George Mullet Prize in Clinical Psychiatry 2016
  • Novartis Prize in Neuroscience 2015
  • Scholar of Trinity College Dublin 2013
  • De Renzy Prize in Public Healthy and Primary Care 2016
  • Sheppard Memorial Prize in General Practice 2015
  • Amulree Prize in Geriatric Medicine, Runner Up 2015
  • Health Research Board Student Scholar 2015
  • British Pharmacological Society Undergraduate Prize 2014
  • Walter Smith Prize in Pharmacology & Therapeutics 2014
  • Henry Hutchinson Medical Scholarship 2012
  • Irish Gerontological Society Present
  • British Geriatrics Society Present
  • SpR Representative, Irish Gerontological Society (IGS) National Executive Committee (NEC) 2021
  • Editorial Fellow, Age & Ageing (Journal) 2022
  • Editorial Board Member, BMC Geriatrics 2021