Professor Derek Doherty

• Petrasca A, Doherty DG, Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells, Frontiers in Immunology, 2014, 650-Journal Article, 2014, DOI , URL , TARA - Full Text
• Conroy M.J, Mac Nicholas R, Taylor M, O'dea S, Mulcahy F, Norris S, Doherty D.G, Increased frequencies of circulating IFN---producing V-1+ and V-2+ -- T cells in patients with asymptomatic persistent Hepatitis B virus infection, Viral Immunology, 28, (4), 2015, p201 - 208Journal Article, 2015, DOI , URL
• Maher C.O, Dunne K, Comerford R, O'Dea S, Loy A, Woo J, Rogers T.R, Mulcahy F, Dunne P.J, Doherty D.G, Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by V-1 T cells, Journal of Immunology, 194, (12), 2015, p5953 - 5960Journal Article, 2015, DOI , URL
• Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780Journal Article, 2015, DOI , URL
• Tyler C., Doherty D., Moser B., Eberl M., Human Vγ9Vδ2 T cells: Innate adaptors of the immune system, Cellular Immunology, 296, (1), 2015, p10-21Review Article, 2015, DOI , TARA - Full Text
• Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22Journal Article, 2016, DOI
• Conroy MJ, Mac Nicholas R, Grealy R, Taylor M, Otegbayo JA, O'Dea S, Mulcahy F, Ryan T, Norris S, Doherty DG, Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-" or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection., Journal of viral hepatitis, 22, (3), 2015, p335-45Journal Article, 2015, DOI
• Conroy MJ, Mac Nicholas R, Grealy R, Taylor M, Otegbayo JA, O'Dea S, Mulcahy F, Ryan T, Norris S, Doherty DG, Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-" or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection., Journal of viral hepatitis, 22, (3), 2015, p335-45Journal Article, 2015, DOI
• Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885Journal Article, 2016, DOI
• Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338Journal Article, 2016, DOI , URL
• Arduini S, Dunne J, Conlon N, Feighery C, Doherty D.G, Mucosal-associated invariant T cells are depleted and functionally altered in patients with common variable immunodeficiency, Clinical Immunology, 176, 2017, p23 - 30Journal Article, 2017, DOI , URL
• Doherty D.G, Immunity, tolerance and autoimmunity in the liver: A comprehensive review, Journal of Autoimmunity, 66, 2016, p60 - 75Review Article, 2016, DOI , URL
• Ghnewa YG, O'Reilly VP, Vandenberghe E, Browne PV, McElligott AM, Doherty DG, Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells, Clinical Immunology, 183, 2017, p91 - 98Journal Article, 2017, URL
• Fazekas B, Moreno-Olivera A, Kelly Y, O'Hara P, Murray S, Kennedy A, Conlon N, Scott J, Melo AM, Hickey FB, Dooley D, O'Brien EC, Moran S, Doherty DG, Little MA., Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury., Clinical & Experimental Immunology, 191, (2), 2018, p180 - 188Journal Article, 2018, DOI
• Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-Journal Article, 2018, URL
• Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156-Journal Article, 2018, URL
• Petrasca A, Melo AM, Breen EP, Doherty DG, Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells, Immunology Letters, 196, 2018, 126-134Journal Article, 2018, DOI , URL
• Galvin KC, Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J, Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma, Cancer Letters, 418, 2018, 230 - 238Journal Article, 2018, URL
• Orikiiriza J, Nakawesi J, Kikaire B, Turitwenka D, Schlech W, Kambugu A, Lamorde M, Normark J, Hennessy M, Musiime V, Rujumba J, Ndeezi G, Tumwesigye NM, Doherty DG, Achan J, Unmet needs persist in pediatric HIV programs: lessons from selected case studies in Uganda. , AIDS , 31, 2017, p1196 - 1199Journal Article, 2017, DOI , TARA - Full Text
• Orikiiriza J, Nakawesi J, Kikaire B, Turitwenka D, Schlech W, Kambugu A, Lamorde M, Normark J, Hennessy M, Musiime V, Rujumba J, Ndeezi G, Tumwesigye NM, Doherty DG, Achan J, Unmet needs persist in pediatric HIV programs: lessons from selected case studies in Uganda. , AIDS , 31, 2017, p1196 - 1199Journal Article, 2017, DOI , TARA - Full Text
• Petrasca A, Doherty DG. , Vδ2 T cells differentially stimulate the production of proinflammatory cytokines by dendritic cells and B cells. , 15th International Congress of Immunology, Milan, Italy, 22-27 August 2013, Medimond, Bologna, Italy , 2014, pp21 - 24Conference Paper, 2014
• Arnaiz B, Madrigal-Estebas L, Todryk S, James TC, Doherty DG, Bond U, A novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens., Journal of immune based therapies and vaccines, 2006Journal Article, 2006
• Thomson L, Donaldson P, Doherty D, Devlin J, Williams R, Detection of donor-specific microchimerism following liver transplantation., Transplantation, 1995Journal Article, 1995
• Melo, A.M. and Zhang, L. and Dockry, E.F. and Petrasca, A. and Ghnewa, Y.G. and Breen, E.P. and Morrissey, M.E. and O'Reilly, C. and Bruen, R. and O'Meara, A. and Lysaght, J. and Zhu, X. and Doherty, D.G., Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells, Glycobiology, 28, (7), 2018, p512-521Journal Article, 2018, DOI , URL
• Doherty, D.G. and Melo, A.M. and Moreno-Olivera, A. and Solomos, A.C., Activation and regulation of B cell responses by invariant natural killer T cells, Frontiers in Immunology, 9, (JUN), 2018Review Article, 2018, DOI , URL , TARA - Full Text
• Dunne, P.J. and Maher, C.O. and Freeley, M. and Dunne, K. and Petrasca, A. and Orikiiriza, J. and Dunne, M.R. and Reidy, D. and O'Dea, S. and Loy, A. and Woo, J. and Long, A. and Rogers, T.R. and Mulcahy, F. and Doherty, D.G., CD3ε Expression defines functionally distinct subsets of VÎŽ1 T cells in patients with human immunodeficiency virus infection, Frontiers in Immunology, 9, (MAY), 2018Journal Article, 2018, DOI , URL , TARA - Full Text
• Huggard D, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno A, Melo AM, Doherty DG, Molloy EJ, Altered endotoxin responsiveness in healthy children with Down syndrome., BMC immunology, 2018Journal Article, 2018, DOI , TARA - Full Text
• Huggard D, McGrane F, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno A, Melo AM, Doherty DG, Molloy EJ, Altered endotoxin responsiveness in healthy children with Down syndrome., BMC immunology, 2018Journal Article, 2018, DOI , TARA - Full Text
• Doherty, D.G., Antigen-specific immune tolerance in the liver, Nature Biomedical Engineering, 2019Journal Article, 2019, DOI , URL
• Huggard D, Koay WJ, Kelly L, McGrane F, Ryan E, Lagan N, Roche E, Balfe J, Leahy TR, Franklin O, Moreno-Oliveira A, Melo AM, Doherty DG, Molloy EJ., Altered Toll-Like Receptor Signalling in Children with Down Syndrome., Mediators of inflammation, 2019, 2019, p4068734Journal Article, 2019, DOI
• Deslyper, G., Doherty, D.G., Carolan, J.C. & Holland, Celia V., The role of the liver in the migration of parasites of global significance, Parasites & Vectors, 12, (531), 2019Journal Article, 2019
• Anthony M McElligott , Eamon P Breen , Ruth Cleary , Sarah Brophy, Fiona McCarthy , Emma Heffernan , Vincent O'Mahony , Nicola Gardiner , Derek G Doherty, Bridgette Byrne , Paul V Browne , Catherine M Flynn, , Characterisation of Naive Immunological Profile of Umbilical Cord Blood: The Role of Mucosal-Associated Invariant T Cells and Functional Defects of T Cells and Natural Killer Cells, Blood, American Society of Hematology, San Diego, CA, USA, 1-4 Dec, 2018, 130, (1), American Society of Hematology, 2017, pp3590-Poster, 2017, DOI
• Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938Journal Article, 2020, DOI , TARA - Full Text
• Dean Huggard, Lynne Kelly, Emer Ryan, Fiona McGrane, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Derek G. Doherty, Eleanor J. Molloy, Increased systemic inflammation in children with Down syndrome, Cytokine, 127, 2020, p154938Journal Article, 2020, DOI , TARA - Full Text
• Coakley JD, Breen EP, Moreno-Olivera A, Al-Harbi AI, Melo AM, O'Connell B, McManus R, Doherty DG, Ryan T., Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis, PLoS One, 14, (10), 2019, pe0224276-Journal Article, 2019, DOI
• Melo AM, Maher SG, O'Leary SM, Doherty DG, Lysaght J, Selective effects of radiotherapy on viability and function of invariant natural killer T cells in vitro, Radiotherapy and Oncology, 145, 2020, p128 - 136Journal Article, 2020, DOI , TARA - Full Text
• L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90Journal Article, 1997, DOI
• O'Gorman P, Naimimohasses S, Monaghan A, Kennedy M, Melo AM, Ní Fhloinn D, Doherty DG, Beddy P, Finn SP, Moore JB, Gormley J, Norris S. , Improvement in histological endpoints of MAFLD following a 12-week aerobic exercise intervention, Alimentary Pharmacology and Therapeutics, 52, (8), 2020, p1387-1398Journal Article, 2020, URL , TARA - Full Text
• Coakley J.D., Breen E., Moreno-Olivera A., Al-Harbi A., Melo A., O'Connell B., McManus R., Doherty D., Ryan T. , Innate lymphocyte Th1 and Th17 responses in elderly hospitalised patients with infection and sepsis., Vaccines, 8, (2), 2020, p311-Journal Article, 2020, DOI , URL
• O'Gorman, P., Strahan, O., Ferguson, D., Monaghan, A., Kennedy, M., Forde, C., Melo, A., Doherty, D., O'Brien, K., McKiernan, S., Kenny, R., Coen, R.F., Doherty, C., Bergin, C., Gormley, J., Norris, S. , Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C., Journal of Viral Hepatitis , 2020Journal Article, 2020, TARA - Full Text
• Deslyper,G., Murphy, D.M., Sowemimo, O.A., Holland, C.V. and Doherty, D.G., Distinct hepatic myeloid and lymphoid cell repertoires are associated with susceptibility and resistance to Ascaris infection, Parasitology, 148, (5), 2021, p539 - 549Journal Article, 2021, TARA - Full Text
• Melo A.M., Conroy M.J., Foley E.K., Dockry E., Breen E.P., Reynolds J.V., Lysaght J., Doherty D.G., CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies, Cancer Immunology, Immunotherapy, 69, (6), 2020, p969 - 982, p969-982Journal Article, 2020, DOI , TARA - Full Text
• Huggard D., Doherty D.G., Molloy E.J., Immune Dysregulation in Children With Down Syndrome, Frontiers in Pediatrics, 8, 2020Journal Article, 2020, DOI , TARA - Full Text
• Ashanty M.Melo, Eimear Mylod, Vivienne Fitzgerald, Noel E.Donlon, Dearbhla M. Murphy, Emma K.Foley, Anshul Bhardwaj, John V.Reynolds, Derek G.Doherty, Joanne Lysaght, Margaret R. Dunne, Melissa J. Conroy, Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma, Clinical Immunology, 229, 2021Journal Article, 2021, DOI , TARA - Full Text
• Huggard D, Kelly L, Worrall A, Gallagher G, Fallah L, Yoo LL, McGrane F, Lagan N, .Roche E, Balfe J, Doherty DG, Molloy EJ, Melatonin as an immunomodulator in children with Down syndrome, Pediatric Research, 2022Journal Article, 2022, DOI , TARA - Full Text
• Dunne MR, Wagener J, Loeffler J, Doherty DG, Rogers TR, Unconventional T cells - New players in antifungal immunity., Clinical Immunology, 227, 2021, p108734-Journal Article, 2021, DOI , TARA - Full Text
• Taher NAB, Kelly LA, Al-Harbi AI, O'Dea MI, Zareen Z, Ryan E, Molloy EJ, Doherty DG, Altered distributions and functions of natural killer T cells and γδ T cells in neonates with neonatal encephalopathy, in school-age children at follow-up, and in children with cerebral palsy, Journal of Neuroimmunology, 15, (356), 2021, p577597-Journal Article, 2021, DOI , URL , TARA - Full Text
• Ma Y, Su H, Yuksel M, Longhi MS, McPhail MJ, Wang P, Bansal S, Wong GW, Graham J, Yang L, J Thompson R, Doherty DG, Hadzic N, Zen Y, Quaglia A, Heneghan MA, Samyn M, Vergani D, Mieli-Vergani G, Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry, 74, (4), 2021, p2032-2046Journal Article, 2021, TARA - Full Text
• Ssekamatte P, Nakibuule M, Nabatanzi R, Egesa M, Musubika C, Bbuye M, Hepworth MR, Doherty DG, Cose S, Biraro IA., Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda, Frontiers in Immunology, 12, 2021, p716819-Journal Article, 2021, DOI
• Melo AM, Taher NA, Doherty DG, Molloy EJ, The role of lymphocytes in neonatal encephalopathy., Brain Behavior and Immunity Health, 18, 2021, p100380-Journal Article, 2021, DOI , URL , TARA - Full Text
• Can the immune system be targeted to treat COVID-19? in, editor(s)Aurelie Fabre, John R. Hurst and Sheila Ramjug , ERS Monograph - COVID-19, European Respiratory Society, 442 Glossop Road, Sheffield, S10 2PX, UK, European Respiratory Society, 2021, pp69 - 85, [Sarah Abdelhafeez and Derek Doherty]Book Chapter, 2021, URL
• Singh K, Cogan S, Elekes S, Murphy DM, Cummins S, Curran R, Najda Z, Dunne MR, Jameson G, Gargan S, Martin S, Long A, Doherty DG., SARS-CoV-2 spike and nucleocapsid proteins fail to activate human dendritic cells or "" T cells., PloS one, 17, (7), 2022, pe0271463Journal Article, 2022, DOI
• Hawerkamp HC, Dyer AH, Patil ND, McElheron M, O'Dowd N, O'Doherty L, Mhaonaigh AU, George AM, O'Halloran AM, Reddy C, Kenny RA, Little MA, Martin-Loeches I, Bergin C, Kennelly SP, Donnelly SC, Bourke NM, Long A, Sui J, Doherty DG, Conlon N, Cheallaigh CN, Fallon PG., Characterisation of the pro-inflammatory cytokine signature in severe COVID-19., Frontiers in Immunology , 14, 2023, p1170012-Journal Article, 2023, URL
• Alharbi B, Qanash H, Binsaleh NK, Alharthi S, Elasbali AM, Gharekhan CH, Mahmoud M, Lioudakis E, O'Leary JJ, Doherty DG, Mohamed BM, Gray SG., Proof of concept nanotechnological approach to in vitro targeting of malignant melanoma for enhanced immune checkpoint inhibition, Scientific Reports, 13, 2023, p7462-Journal Article, 2023
• Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8Journal Article, 2008, DOI , URL
• Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40Journal Article, 2008, DOI , URL
• Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72Journal Article, 2007, DOI , URL
• Dean, J, McCarthy, D, Lawler, M, Doherty, DG, O'Farrelly, C, Golden-Mason, L, Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical immunology (Orlando, Fla.), 114, (1), 2005, p42-51Journal Article, 2005, DOI , URL
• Kenna, T, Golden-Mason, L, Norris, S, Hegarty, JE, O'Farrelly, C, Doherty, DG, Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver., Clinical immunology (Orlando, Fla.), 113, (1), 2004, p56-63Journal Article, 2004, DOI , URL
• O'Keeffe, J, Doherty, DG, Kenna, T, Sheahan, K, O'Donoghue, DP, Hyland, JM, O'Farrelly, C, Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer., European journal of immunology, 34, (8), 2004, p2110 - 2119Journal Article, 2004, DOI , URL
• Golden-Mason, L, Kelly, AM, Doherty, DG, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development., Clinical and experimental immunology, 138, (1), 2004, p94-101Journal Article, 2004, DOI , URL , TARA - Full Text
• Kelly, AM, Golden-Mason, L, McEntee, G, Traynor, O, Doherty, DG, Hegarty, JE, O'Farrelly, C, Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo., Cytokine, 25, (6), 2004, p273-282Journal Article, 2004, DOI , URL
• Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779Journal Article, 2003, URL
• Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535Journal Article, 2003
• Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50Journal Article, 2003, DOI , URL
• Byrne, B, Madrigal-Estebas, L, McEvoy, A, Carton, J, Doherty, DG, Whelan, A, Feighery, C, O'Donoghue, DP, O'Farrelly, C, Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules., Human immunology, 63, (11), 2002, p977-86Journal Article, 2002, DOI , URL
• Deignan, T, Curry, MP, Doherty, DG, Golden-Mason, L, Volkov, Y, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection., Journal of Hepatology, 37, (1), 2002, p101-8Journal Article, 2002, DOI , URL
• Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8Journal Article, 2003, DOI , URL
• Madrigal-Estebas, L, Doherty, DG, O'Donoghue, DP, Feighery, C, O'Farrelly, C, Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells., Mediators of inflammation, 11, (5), 2002, p313-319Journal Article, 2002, DOI , URL , TARA - Full Text
• Curry, MP, Norris, S, Golden-Mason, L, Doherty, DG, Deignan, T, Collins, C, Traynor, O, McEntee, GP, Hegarty, JE, O'Farrelly, C, Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization., Journal of Immunological Methods, 242, (1-2), 2000, p21-31Journal Article, 2000, DOI
• Doherty, DG, Norris, S, Madrigal-Estebas, L, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns., Journal of immunology (Baltimore, Md. : 1950), 163, (4), 1999, p2314-21Journal Article, 1999, URL
• Norris, S, Doherty, DG, Collins, C, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells., Human immunology, 60, (1), 1999, p20-31Journal Article, 1999, DOI , URL
• Norris, S, Collins, C, Doherty, DG, Smith, F, McEntee, G, Traynor, O, Nolan, N, Hegarty, J, O'Farrelly, C, Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes., Journal of hepatology, 28, (1), 1998, p84 - 90Journal Article, 1998
• Oliveira AL, Hayakawa H, Schor D, Leite AC, Espíndola OM, Waters A, Dean J, Doherty DG, Araújo AQ, Hall WW, High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection., Journal of Immunology, 183, 2009, p2957-2965Journal Article, 2009, DOI
• Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901Journal Article, 2009, DOI
• Kelly-Rogers J, Madrigal-Estebas L, O'Connor T, Doherty DG. , Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro. , Human Immunology, 67, 2006, p863-673Journal Article, 2006, DOI
• Arnaiz B, Madrigal-Estebas L, Todryk S, James TC, Doherty DG, Bond U., A Novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens., Journal of Immune Based Therapies and Vaccines, 4, (12), 2006, p1-12Journal Article, 2006, DOI
• Differential cytokine production by T cells that are positive or negative for CD56. in, Immunology, Bologna, Italy , Medimond, 2004, pp103 - 108, [Kelly Rogers J, Doherty DG.]Book Chapter, 2004
• Cookson S, Doherty DG, Todryk S, Gibbs P, Portmann B, O'Grady J, Rela M, Heaton N, Norris S., Hepatic expression of IL-15 mRNA is associated with liver graft acceptance. , Transplantation Immunology, 11, (1), 2003, p39-49Journal Article, 2003, DOI
• Czaja A, Doherty DG, Donaldson PT., The genetic bases of autoimmune hepatitis., Digestive Diseases and Sciences, 47, (10), 2002, p2139-2150Journal Article, 2002, DOI
• Dunne J, Lynch S, O'Farrelly C, Hegarty JE, Feighery C, Doherty DG., Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. , Journal of Immunology, 167, (6), 2001, p3129-3138Journal Article, 2001, URL
• Doherty D.G., Presentation of auto-epitopes by major histocompatibility complex molecules in autoimmune hepatitis., Syllabus of the American Association for the Study of Liver Diseases Single Topic Conference on Autoimmune Hepatitis, 2000, pp33-41Conference Paper, 2000
• Doherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT., Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous contacts between the T cell receptor, peptide and HLA-DR. , Journal of Immunology, 161, (7), 1998, p3527-3535Journal Article, 1998, URL
• Devlin J, Doherty D, Thomson L, Wong T, Donaldson P, Portmann B, Williams R. , Defining the outcome of immunosuppression withdrawal after liver transplantation. , Hepatology, 27, (4), 1998, p926-933Journal Article, 1998, DOI
• Doherty, D.G., O'Farrelly, C., Dendritic cells: Regulators of hepatic immunity or tolerance?, Journal of Hepatology, 34, (1), 2001, p156-160Journal Article, 2001, DOI
• Doherty, D.G., O'Farrelly, C., Innate and adaptive lymphoid cells in the human liver , Immunological Reviews, 174, (1), 2000, p5-20Review Article, 2000, DOI
• Gregorio, G.V., Portmann, B., Reid, F., Donaldson, P.T., Doherty, D.G., McCartney, M., Mowat, A.P., (...), Mieli-Vergani, G., Autoimmune hepatitis in childhood: A 20-year experience , Hepatology , 25, (3), 1997, p541-547Journal Article, 1997, DOI
• Doherty DG, Koelle DM, Kwok WW, Masewicz S, Domeier ME, Nepom GT., Amino acid residues in the alpha-helical portions of HLA-DR molecules can modulate T cell recognition of antigen., HLA.Genetic Diversity of HLA: Functional and Medical Implication, Paris, France, edited by Charron, D , EDK Medical and Scientific International Publisher, 1997, pp540-542Conference Paper, 1997
• Wright, P., Donaldson, P.T., Underhill, J.A., Choudhuri, K., Doherty, D.G., Murray, R.M., Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia, American Journal of Psychiatry , 153, (12), 1996, p1530-1533Journal Article, 1996, URL
• Penzotti JE, Doherty DG, Lybrand TP, Nepom GT., A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis., Journal of Autoimmunity, 9, (2), 1996, p287-293Journal Article, 1996, DOI
• Duthie A, Doherty DG, Donaldson PT, Scott-Jupp R, Tanner MS, Eddleston ALWF, Mowat AP. , The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis., Journal of Hepatology, 23, (5), 1995, p532-537Journal Article, 1995, DOI
• Thomson L, Donaldson P, Doherty D, Devlin J, Williams R. , Detection of microchimerism following liver transplantation., 1995, - 769Miscellaneous, 1995, URL
• Underhill JA, Donaldson PT, Doherty DG, Manabe K, Williams R., HLA DPB polymorphism in primary sclerosing cholangitis and primary biliary cirrhosis., Hepatology, 21, (4), 1995, p959-962Journal Article, 1995, DOI
• Teh LS, Doherty DG, Williams BD. , HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus., British Journal of Rheumatology, 33, (12), 1994, p1125-1126Journal Article, 1994, URL
• Doherty DG, Underhill JA, Donaldson PT, Manabe K, Mieli-Vergani G, Eddleston ALWF, Vergani D, Demaine AG, Williams R, Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis., Autoimmunity, 18, (4), 1994, p243-249Journal Article, 1994, DOI
• Manabe K, Hibberd ML, Donaldson PT, Underhill JA, Doherty DG, Demaine AG, Mieli-Vergani G, Eddleston ALWF, Williams R. , T-cell receptor constant β germline gene polymorphisms and susceptibility to autoimmune hepatitis , Gastroenterology , 106, (5), 1994, p1321-1325Journal Article, 1994, URL
• Doherty DG, Donaldson PT, Underhill PT, Farrant JM, Duthie A, Mieli-Vergani G, McFarlane IG, Johnson PJ, Eddleston ALWF, Mowat AP, Williams R. , Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis. , Hepatology , 19, (3), 1994, p609-615Journal Article, 1994, DOI
• Manabe K, Donaldson PT, Underhill JA, Doherty DG, Mieli-Vergani G, McFarlane IG, Eddleston ALWF, Williams R. , Human leukocyte antigen A1-B8-DR3-DQ2-DPB1*0401 extended haplotype in autoimmune hepatitis. , Hepatology, 18, (6), 1993, p1334-1337Journal Article, 1993, DOI
• Donaldson P, Underhill J, Doherty D, Hayllar K, Calne R, Tan K-C, O'Grady J, Wight D, Portmann B, Williams R. , Influence of human leukocyte matching on liver allograft survival and rejection: the "dualistic effect"., Hepatology, 17, (6), 1993, p1008-1015Journal Article, 1993, DOI
• Underhill J, Donaldson PT, Bray G, Doherty D, Portmann, Williams R., Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype. , Hepatology, 16, (6), 1992, p1414-1408Journal Article, 1992, DOI
• Farrant JM, Doherty DG, Donaldson PT, Vaughan RW, Hayllar KM, Welsh KI, Eddleston ALWF, Williams R., Amino acid substitutions at position 38 of the DR beta polypeptide confer susceptibility to and protection from primary sclerosing cholangitis., Hepatology, 16, (2), 1992, p390-395Journal Article, 1992, DOI
• Doherty DG, Vaughan RW, Donaldson PT, Mowat AP. , HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British Caucasoids., Human Immunology , 34, (1), 1992, p53-63Journal Article, 1992, DOI
• Bidwell JL, Soong TW, Raymond PA, Doherty DG, Hui KM., HLA genotyping of colorectal carcinoma in the Chinese population., Human Immunology, 34, (1), 1992, p19-23Journal Article, 1992, DOI
• Doherty DG, Ireland R, Demaine AG, Wang F, Veerapan K, Welsh KI, Vergani D., Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern Chinese., Arthritis and Rheumatism, 35, (6), 1992, p641-646Journal Article, 1992, DOI
• Duthie A, Doherty DG, Williams C, Scott-Jupp R, Warner JO, Tanner MS, Williamson R, Mowat AP. , Genotype analysis for ΔF508, G551D and R553X mutations in children and young adults with cystic fibrosis with and without chronic liver disease, Hepatology , 15, (4), 1992, p660-664Journal Article, 1992, DOI
• Asherson RA, Doherty DG, Vergani D, Khamashta MA, Hughes GRV. , Major histocompatibility complex associations with primary antiphospholipid syndrome., Arthritis and Rheumatism , 35, (6), 1992, p124-125Journal Article, 1992, DOI
• Donaldson PT, Doherty DG, Hayllar KM, McFarlane IG, Johnson PJ, Williams R., Susceptibility to autoimmune chronic hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors., Hepatology, 13, (4), 1991, p701-706Journal Article, 1991, DOI
• Doherty DG, Donaldson PT. , HLA-DRB and DQB typing by a combination of serology, restriction fragment length polymorphism analysis and oligonucleotyde probing., European Journal of Immunogenetics, 18, (1-2), 1991, p111-124Journal Article, 1991, DOI
• Doherty DG, Donaldson PT, Whitehouse DB, Mieli-Vergani G, Duthie A, Hopkinson DA, Mowat AP. , HLA phenotypes and gene polymorphisms in juvenile liver disease associated with a1-antitrypsin deficiency., Hepatology, 12, (2), 1990, p218-223Journal Article, 1990, DOI
• Russell SEH, Hull JD, Doherty DG, Clarke DK, Hoey EM, Rima BK, Martin SJ. , Molecular cloning of measles and canine distemper viruses., Biochemical Society Transactions, 13, 1985, p478-479Journal Article, 1985
• Donaldson P, Doherty D, Underhill J, Williams R., The molecular genetics of autoimmune liver disease., Hepatology, 20, 1994, p225-239Review Article, 1994, DOI
• Immunogenetic influences in primary biliary cirrhosis. in, editor(s)Meyer zum Buschenfelde K-H, Hoofnagle J, Manns M , 70th Falk Symposium, Basel, Switzerland, Kluwer Academic Press, 1993, pp383-396 , [Donaldson PT, Doherty DG, Underhill JA, Williams R.]Book Chapter, 1993
• Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207Journal Article, 2011, DOI , URL , TARA - Full Text
• Dunne MR, Mangan BA, Madrigal-Estebas L, Doherty DG, Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells, Mediators of Inflammation, 2010, (704941), 2010Journal Article, 2010, DOI , URL , TARA - Full Text
• Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D. , Cigarette smoke alters invariant natural killer T cell function and may inhibit antitumour responses. , Clinical Immunology, 2011Journal Article, 2011, DOI
• White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T, Hospital acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression, Chest, 139, 2011, p626 - 632Journal Article, 2011, DOI
• Dunne MR, Madrigal-Estebas L, Tobin LM, Doherty DG, (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vã9Vä2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells, Cancer Immunology Immunotherapy , 59, 2010, p1109 - 1120Journal Article, 2010, DOI , URL , TARA - Full Text
• Garland MR, Lavelle E, Doherty D, Golden-Mason L, Fitzpatrick P, Hill A, Walsh N, O'Farrelly C, Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer, Psychological Medicine , 34, 2004, p481 - 490Journal Article, 2004
• Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A, Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion, Hepatology, Mar 30, (doi: 10.1002/hep.243), 2011Journal Article, 2011, DOI
• Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D, Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis., Diabetologia, 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158Journal Article, 2011, DOI , URL , TARA - Full Text
• White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158Journal Article, 2011, DOI , URL , TARA - Full Text
• Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A, Hepatitis C virus - T-cell responses and viral escape mutations., European journal of immunology, 42, (1), 2012, p17-26Journal Article, 2012, DOI
• O'Reilly V, Zeng SG, Bricard G, Atzberger A, Hogan AE, Jackson J, Feighery C, Porcelli SA, Doherty DG, Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8α and CD4CD8α Invariant Natural Killer T Cells, PloS one, 6, (12, e28648), 2011Journal Article, 2011, DOI , URL , TARA - Full Text
• Baird AM, Dockry E, Daly A, Stack E, Doherty DG, O'Byrne KJ, Gray SG, IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer., Frontiers in oncology, 3, 2013, p162-Journal Article, 2013, DOI , TARA - Full Text
• Kennedy, A. Doherty , D.G Petrasca, A. Hennessy, M. Spiers, J.P., HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes, AIDS, 28, 2014, p131 - 133Journal Article, 2014, DOI
• Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human V"3 T cells., Journal of immunology (Baltimore, Md. : 1950), 191, (1), 2013, p30-4Journal Article, 2013, DOI , TARA - Full Text
• Dunne, MR, Elliott, L, Hussey, S, Mahmud, N, Kelly, J, Doherty, DG, Feighery, CF, Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease, PLOS ONE, 8, (10), 2013, p76008Journal Article, 2013, DOI , URL , TARA - Full Text
• Zeng, SG, Ghnewa, YG, O'Reilly, VP, Lyons, VG, Atzberger, A, Hogan, AE, Exley, MA, Doherty, DG, Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro, JOURNAL OF IMMUNOLOGY, 191, (4), 2013, p1666-1676Journal Article, 2013, DOI
• Grealy, R, White, M, Stordeur, P, Kelleher, D, Doherty, DG, McManus, R, Ryan, T, Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis, Mediators of Inflammation, 2013, 2013, 164246Journal Article, 2013, DOI , TARA - Full Text
• Murphy N, Petrasca A, Murphy NM, Reilly VO, Evans P, Doherty DG, Zhu XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377Journal Article, 2013, URL
• Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, Parat MO, Sessler DI, Shorten G, Singleton P., Consensus statement from the BJA Workshop on Cancer and Anaesthesia., British Journal of Anaesthesia, Aug 7, 2014, ppii: aeu26-Journal Article, 2014, DOI

• Core concepts in immunology. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practice, New York, Springer Science and Business Media, 2014, pp11 - 26, [O'Farrelly C, Doherty DG]Book Chapter
• Basic immunological terms and concepts: a short primer of fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp1 - 13, [O'Farrelly C, Doherty DG]Book Chapter
• Ssekamatte P, Nakibuule M, Nabatanzi R, Egesa M, Musubika C, Bbuye M, Hepworth MR, Doherty DG, Cose S, Biraro IA., Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda, Frontiers in Immunology, 12, 2021, p716819-Journal Article, DOI , TARA - Full Text
• Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ]Book Chapter
• A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ]Book Chapter
• Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.]Book Chapter
• The human major histocompatibility complex and disease susceptibility. in, Rimoin DL, Connor JM, Pyeritz RE , Emery and Rimoin's Principles and Practice of Medical Genetics, New York, Churchill Livingstone, 1997, pp497-504 , [Doherty DG, Nepom GT. ]Book Chapter

Our research is aimed at finding out how the immune system protects against or causes disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in populations of 'innate lymphocytes' (natural killer cells, natural killer T cells, gamma/delta T cells and mucosal-associated invariant T cells), which appear to be master regulators of the immune system. Innate lymphocytes can be trained to prevent and treat infectious and immune-mediated diseases and cancers in animal models. Various innate lymphocyte populations are being targeted in clinical trials for cancer in humans, and although the results are promising, no such cellular therapy has yet received approval. In order to improve the efficacy of innate lymphocyte therapies that are currently being tested and to develop new treatments, we are investigating the molecular and cellular interactions that take place between innate lymphocytes, pathogens and other cells. We have shown that innate lymphocytes are heterogeneous with diverse effector functions including tumour cell killing, the release of cytokines that activate or suppress the actions of T cells, and contact-dependent stimulatory and regulatory interactions with monocytes, macrophages, dendritic cells and B cells. In collaboration with clinical colleagues, we have found that innate lymphocyte populations are numerically and/or functionally impaired in patients with hepatitis B and C, HIV, candidiasis, chronic lymphocytic leukaemia, oesophageal, stomach, colorectal, liver and lung cancer, post-operative infection and sepsis, coeliac disease, autoimmune vasculitis, antibody deficiencies and neonatal encephalopathy. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of multiple diseases and this has led to funded collaborations with three biotechnology/pharmaceutical companies, in which we are pooling our efforts to develop robust therapies for cancer, infectious and autoimmune disease.

• Title

  Phenotypic, molecular and functional characterisation of a novel lymphocyte in the normal human liver
  Summary

  Consumable funds for the characterisation of a novel type of T cell in human liver. IR£16,300.
  Funding Agency

  Forbairt
  Date From

  1996
  Date To

  1998
• Title

  Nutrition and Treatment Outcome: Development of a Ugandan - Irish HIV / Nutrition Research Cluster
  Summary

  To determine the roles of nutrition, food security and education on the outcome of treatment of HIV infection in adults and children in Uganda
  Funding Agency

  Irish Aid and the Higher Education Authority
  Date From

  2012
  Date To

  2016
• Title

  Understanding the immune response to influenza vaccination in patients with haematological malignancy
  Summary

  Analysis of T cell and antibody responses to vaccines against influenza and other pathogens in patients undergoing allogeneic stem cell transplantation.
  Funding Agency

  Irish Clinical Academic Training (ICAT) Programme
  Date From

  2023
  Date To

  2026
• Title

  Flow cytometric Cell Sorter
  Summary

  This grant funded the purchase of a FACSAria Cell Sorter for the Institute of Immunology at Maynooth University. €300,000
  Funding Agency

  Science Foundation Ireland
  Date From

  2006
• Title

  Translational approaches to enhance Human γδ T lymphocytes targeting of non-small-cell lung cancer
  Summary

  Investigating the use of epigenetic modifying agents to augment antitumour immunity by inducing CD1d expression
  Funding Agency

  Molecular Medicine Ireland
  Date From

  2012
  Date To

  2015
• Title

  CD1d binding peptide motifs for the stimulation of NKT cells.
  Summary

  To develop novel CD1d-binding peptides as treatments for cancer
  Funding Agency

  ImCyse Specific Active Immunotherapeutics
  Date From

  2017
  Date To

  2019
• Title

  The role and treatment potential of innate lymphocytes in neonatal brain injury
  Summary

  Investigating the roles of innate T cells in inflammation associated with neonatal encephalopathy
  Funding Agency

  Libyan Embassy
  Date From

  2016
  Date To

  2019
• Title

  The role of natural killer T cells in B cell maturation and antibody responses
  Summary

  Investigating the ability of human iNKT cells to promote differentiation and activation of B cells
  Funding Agency

  Health Research Board
  Date From

  2007
  Date To

  2011
• Title

  The role of intrahepatic gamma delta T cells in immunity against hepatitis C virus
  Summary

  Examining the roles of virus specific hepatic CD8 T cells in immunity against hepatitis C virus. IR£129,260
  Funding Agency

  Health Research Board
  Date From

  2001
  Date To

  2004
• Title

  Metabolic profiles of innate lymphocytes from patients with sepsis
  Summary

  Investigating how changes in energy metabolism in NK cells and gamma/delta T cells may contribute to the development of sepsis
  Funding Agency

  Royal Embassy of Saudi Arabia
  Date From

  2016
  Date To

  2019
• Title

  Microbeta Trilux Scintillation Counter
  Summary

  This equipment grant funded the purchase of a scintillation counter for the Institute of Immunology at Maynooth University. €45,980.
  Funding Agency

  Health Research Board
  Date From

  2003
• Title

  Characterisation of T cells in human liver
  Summary

  Investigating novel T cell populations in liver biopsies taken from healthy donors and patients with liver malignancy IR£75,000.
  Funding Agency

  Liver Unit, St. Vincent's University Hospital
  Date From

  1996
  Date To

  1998
• Title

  Combating Diseases of Poverty Consortium
  Summary

  Training of students from Africa in biomedical laboratory techniques
  Funding Agency

  Higher Education Authority and Irish Aid
  Date From

  2008
  Date To

  2008
• Title

  Immunogenetic studies on liver transplantation tolerance and chronic liver disease
  Summary

  Determining the influence of donor-specific microchimerism in liver allograft acceptance. Stg £7,131.
  Funding Agency

  King's College Liver Unit Trust
  Date From

  1992
  Date To

  1993
• Title

  Cirrhosis and cystic fibrosis: mechanisms of autoimmune liver damage: use of cDNA probes to evaluate its genetic basis.
  Summary

  An investigation of the role of major histocompatibility complex alleles in the pathogenesis of liver disease in children with cystic fibrosis. Stg £79,601.
  Funding Agency

  Cystic Fibrosis Research Trust
  Date From

  1988
  Date To

  1990
• Title

  The role and treatment potential of "" T cells in patients with chronic lymphocytic leukaemia
  Summary

  We are investigating ways to prime tumour cells from patients with chronic lymphocytic leukaemia for killing by "" T cells
  Date From

  2023
  Date To

  2024
• Title

  Exploring the power of nanotechnology to enhance cancer immunotherapy
  Summary

  We are investigating the use of nanoparticles to improve cellular therapies involving innate T cells for ovarian cancer
  Date From

  2023
  Date To

  2025
• Title

  Characterisation of hepatitis C induced immunological subversion and its implications for treatment response
  Summary

  Determining the roles of immune cells in the liver in the pathogenesis of hepatitis C. €552,000
  Funding Agency

  Health Research Board
  Date From

  2003
  Date To

  2006
• Title

  Innate T cells in COVID-19 and long Covid
  Summary

  We are investigating the numbers, phenotypes and functions of innate T cells in patients with mild, moderate and severe COVID-19 and in patients with long covid to assess their roles and treatment potential for these
  Funding Agency

  Science Foundation Ireland
  Date From

  2020
  Date To

  2024
• Title

  Natural killer cells and natural killer receptor-positive T cells in hepatitis C virus infecti
  Summary

  Analysing the numbers and functions of NK cells and NK-like T cells in patients who cleared and those who did not clear hepatitis C virus
  Funding Agency

  Libyan People's Bureau, London
  Date From

  2002
  Date To

  2003
• Title

  Characterisation of CD1-restricted T cells in the human liver
  Summary

  Identifying and characterising T cells that recognise CD1a, CD1b, CD1c and CD1d in liver biopsies from healthy donors and patients with metastatic liver disease. IR£49,164.
  Funding Agency

  Health Research Board
  Date From

  1999
  Date To

  2002
• Title

  The role and treatment potential of γδ T cells in human immunodeficiency virus infection
  Summary

  Investigating the contribution of γδ T cell subsets to immunodeficiency in patients with HIV infection
  Funding Agency

  Health Research Board
  Date From

  2010
  Date To

  2013
• Title

  The role of natural killer T cells in the control of immune regulation, antigen presentation and antibody production by human B lymphocytes
  Summary

  Investigating how iNKT cells promote differentiation, cytokine and antibody production by B cells from healthy donors and patients with chronic lymphocytic leukaemia
  Funding Agency

  Irish Research Council
  Date From

  2011
  Date To

  2015
• Title

  Phenotypic and functional analysis of innate lymphocytes in patients with low socioeconomic status
  Summary

  We are investigating how socioeconomic status influences immune function focusing on innate T cell numbers and functions.
  Funding Agency

  Self-funded
  Date From

  2023
  Date To

  2024
• Title

  The influence of Vγ9Vδ2 T cells on antigen presentation and antibody production
  Summary

  Investigating the use of Vγ9Vδ2 T cells to stimuate dendritic cells and B cells for the treatment of cancer
  Funding Agency

  Science Foundation Ireland
  Date From

  2011
  Date To

  2015
• Title

  Delivery of Gene Editing Tools to Primary T cells using Profector Technology
  Summary

  Developing novel methods for expressing transgenes in human T cells for cellular therapies
  Funding Agency

  Profector Life Sciences
  Date From

  2016
  Date To

  2018
• Title

  An investigation of diagnostic and prognostic indicators in paediatric patients with antibody deficiency: role of T lymphocytes (conventional, regulatory and innate) in disease pathogenesis
  Summary

  Investigating the role of innate lymphocytes in the pathogenesis of primary antibody deficiency in children
  Funding Agency

  National Children's Research Centre
  Date From

  2011
  Date To

  2014
• Title

  The role of CD1d-restricted natural killer T cells in dendritic cell maturation and differentiation
  Summary

  Investigating the mechanisms by which iNKT cells induce differentiation and activation of dendritic cells. €138,969.
  Funding Agency

  Science Foundation Ireland
  Date From

  2005
  Date To

  2008
• Title

  Virus variants and host immune responses in the resolution and progression of chronic liver disease following hepatitis C infection
  Summary

  Determining the viral and host factors that determine whether a patient clears hepatitis C virus or develops chronic viral infection. IR£741,972.
  Funding Agency

  Health Research Board
  Date From

  1997
  Date To

  2002
• Title

  The role and treatment potential of natural killer T cells in patients with upper gastrointestinal cancer
  Summary

  Investigating the role of type 1 and type 2 NKT cells in oesophageal and gastric cancer
  Funding Agency

  Consejo Nacional de Ciencia y Tecnología (CONACyT)
  Date From

  2015
  Date To

  2018
• Title

  Novel immunoregulatory cells in human omentum.
  Summary

  Investigating the presence of γδ T cells in human omental adipose tissue and characterisation of CD1d recognition by Vδ3 T cells
  Funding Agency

  Health Research Board
  Date From

  2010
  Date To

  2013
• Title

  The influence of glycolipid-specific T lymphocytes on the maturation and function of human dendritic cells
  Summary

  This summer project enabled a secondary level science teacher gain immunology laboratory skills. Doherty DG, Carey M. €9,476.
  Funding Agency

  Science Foundation Ireland
  Date From

  2008
  Date To

  2008
• Title

  The anti-tumour roles of distinct subsets of invariant natural killer T cell
  Summary

  A functional comparison of CD4+, CD8+ and double negative iNKT cells in healthy donors and patients with chronic lymphocytic leukaemia
  Funding Agency

  Health Research Board
  Date From

  2009
  Date To

  2012
• Title

  The functional significance of diversity in human natural killer cell receptors
  Summary

  Determining how killer immunoglobulin receptor (KIR) allotypes affect NK cell functions €154,044.
  Funding Agency

  Enterprise Ireland
  Date From

  2002
  Date To

  2004
• Title

  Activation and regulation of human NKT cells. Doherty DG
  Summary

  Phenotypic and functional characterisation of novel populations of T cells with NK cell receptors. IR£57,190.
  Funding Agency

  Enterprise Ireland
  Date From

  2000
  Date To

  2003
• Title

  Characterisation and manipulation of human T cells with early immunomodulatory function
  Summary

  Analysis of rapid-activating lymphocytes of the immune system. €214,745.
  Funding Agency

  Science Foundation Ireland
  Date From

  2004
  Date To

  2006
• Title

  Cirrhosis in cystic fibrosis: use of DNA probes to evaluate the genetic basis of liver damage
  Summary

  Investigating the role of alleles of the cystic fibrosis gene and the immunogenetic loci in susceptibility to liver disease in patients with cysticv fibrosis. Stg £53,508.
  Funding Agency

  Cystic Fibrosis Research Trust
  Date From

  1990
  Date To

  1992
• Title

  Presentation of lipid peroxidation products by CD1a and CD1d molecules
  Summary

  We are investigating the hypothesis that cosmetic products cause allergic contact dermatitis by modifying skin lipids so that they bind to CD1a or CD1d molecules leading to T cell activation
  Funding Agency

  Irish Research Council and the Panoz Pharmaceutical Innovation PhD Scholarships
  Date From

  2022
  Date To

  2025
• Title

  Haematopoietic stem cell transplantation and CAR-T cell therapy for blood cell malignancies
  Summary

  We are performing a longitudinal analyses of immune cell reconstitution and T cell exhaustion after allogeneic stem cell transplantation and CAR T cell therapy to identify prognostic biomarkers of responses to these treatments and ultimately to develop improved treatments.
  Funding Agency

  Irish Blood Transfusion Service
  Date From

  2021
  Date To

  2027
• Title

  The role and treatment potential of γδ T cells in human immunodeficiency virus infection
  Summary

  Investigating the role of Vδ1 T cells in immunity against Candida albicans, a frequent co-infection in patients with HIV infection
  Funding Agency

  Health Research Board
  Date From

  2012
  Date To

  2013
• Title

  Therapeutic evaluation of plant-based bioactives
  Summary

  We are investigating possible inflammatory or anti-inflammatory properties of extracts from plants that are used medicinally in traditional Indian culture
  Date From

  2022
  Date To

  2024

Medical, Health and Life Sciences & Technologies, Oncology and cancer biology, Biochemistry, Molecular & Cellular Biology, Other Basic Medicine, Immunity and Infection (including Rheumatology & Inflammatory disease), Gastroenterology & Hepatology,

• Elected to Fellowship of Trinity College Dublin 2012

• Secretary, Irish Society for Immunology 2004
• Committee member, Irish Society for Immunology 2018