Medicine

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Trinity Biomedical Sciences Institute
Trinity College
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Dr. Patrick Mitchell

Dr. Patrick Mitchell

Senior Lecturer Consultant, Clinical Medicine


Biography

Patrick Mitchell is a senior lecturer/associate professor of medicine and respiratory consultant physician at Trinity College Dublin and Tallaght University Hospital. Graduating from UCD in 2007 with a medical degree he specialised in internal medicine and respiratory medicine. He undertook a two-year clinical and research fellowship at McMaster University under which entailed translational research in airway inflammation and servicing both general respiratory and airway inflammation clinics. He also completed a two-year Medical Doctorate thesis on the role of IL-33 in allergic asthma. Following his fellowship he was appointed clinical assistant professor of medicine at the University of Calgary, Canada where he was director of the airways disease unit. He returned to Ireland to the above mentioned role with his wife and three children. He has authored numerous peer reviewed research manuscripts and co-authored a book chapter on asthma. Dr. Mitchell's clinical interests are in asthma, Chronic Obstructive Pulmonary Disease (COPD), chronic eosinophilic airways disease, autoimmune pulmonary diseases, Sarcoidosis.

Publications and Further Research Outputs

  • Mitchell PD, Das JP, Murphy DJ, Keane MP, Donnelly SC, Dodd JD, Butler MW, Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among emphysema and idiopathic pulmonary fibrosis in smokers., 2015Journal Article, 2015
  • Kent BD, Mitchell PD, McNicholas WT., Hypoxemia in patients with COPD: cause, effects, and disease progression., International journal of chronic obstructive pulmonary disease, 6, 2011, p199-208Journal Article, 2011, DOI
  • Mitchell, P., Leigh, R., A drug safety review of treating eosinophilic asthma with monoclonal antibodies, Expert Opinion on Drug Safety, 18, (12), 2019, p1161-1170Journal Article, 2019, DOI
  • Satia, I., Watson, R., Scime, T., Dockry, R.J., Sen, S., Ford, J.W., Mitchell, P.D., Fowler, S.J., Gauvreau, G.M., O'Byrne, P.M., Smith, J.A., Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma, Journal of Allergy and Clinical Immunology, 144, (3), 2019, p788-795.e1Journal Article, 2019, DOI
  • Leung, E., Mitchell, P.D., Emerging treatment options in severe asthma, Current Respiratory Medicine Reviews, 14, (2), 2018, p64-76Journal Article, 2018, DOI
  • Mitchell, P.D., Salter, B.M., Oliveria, J.P., El-Gammal, A., Tworek, D., Smith, S.G., Sehmi, R., Gauvreau, G.M., O'Byrne, P.M., IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics, International Archives of Allergy and Immunology, 176, (2), 2018, p133-142Journal Article, 2018, DOI
  • Lim, R., Marciniak, S.J., Marcadier, J., Rassl, D., Mitchell, P.D., Time is of the essence: A young man with recurrent pneumothorax and cavitating lung lesions, Annals of the American Thoracic Society, 15, (8), 2018, p988-989Journal Article, 2018, DOI
  • , Epithelial-Derived Cytokines in Asthma., Chest, 2017Journal Article, 2017, DOI
  • , Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017Journal Article, 2017, DOI
  • , Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma., Pharmacology & therapeutics, 2017Journal Article, 2017, DOI
  • , Anti-IgE and Biologic Approaches for the Treatment of Asthma., Handbook of experimental pharmacology, 2017Journal Article, 2017, DOI
  • Tworek, D., Heroux, D., O'Byrne, S.N., Mitchell, P., O'Byrne, P.M., Denburg, J.A., Toll-like receptor-induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma, Clinical and Experimental Allergy, 47, (7), 2017, p900-908Journal Article, 2017, DOI
  • , Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma., American journal of respiratory and critical care medicine, 2016Journal Article, 2016, DOI
  • , Surfactant Protein-D and Asthma., Chest, 2016Journal Article, 2016, DOI
  • , Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma., Clinical pharmacology and therapeutics, 2016Journal Article, 2016, DOI
  • , IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma., Respiratory research, 2016Journal Article, 2016, DOI
  • Tang, W., Smith, S.G., Salter, B., Oliveria, J.P., Mitchell, P., Nusca, G.M., Howie, K., Gauvreau, G.M., O'Byrne, P.M., Sehmi, R., Allergen-induced increases in interleukin-25 and interleukin-25 receptor expression in mature Eosinophils from Atopic asthmatics, International Archives of Allergy and Immunology, 170, (4), 2016, p234-242Journal Article, 2016, DOI
  • Canonica, G.W., Senna, G., Mitchell, P.D., O"Byrne, P.M., Passalacqua, G., Varricchi, G., Therapeutic interventions in severe asthma, World Allergy Organization Journal, 9, (1), 2016, p1-12Journal Article, 2016, DOI
  • Mitchell, P.D., King, T.J., O"Shea, D.B., Subcutaneous emphysema in acute asthma: A cause for concern?, Respiratory Care, 60, (8), 2015, pe141-e143Journal Article, 2015, DOI
  • Mitchell, P.D., Burke, L.M., Kennedy, M.P., Henry, M.T., A case of pulmonary amyloidosis, Thorax, 69, (6), 2014, p600Journal Article, 2014, DOI
  • Harnett, C.M., Hunt, E.B., Bowen, B.R., O'Connell, O.J., Edgeworth, D.M., Mitchell, P., Eustace, J.A., Henry, M.T., Kennedy, M.P., Plant, B.J., Murphy, D.M., A study to assess inhaler technique and its potential impact on asthma control in patients attending an asthma clinic, Journal of Asthma, 51, (4), 2014, p440-445Journal Article, 2014, DOI
  • Mitchell, P.D., Kennedy, M.P., Bronchoscopic management of malignant airway obstruction, Advances in Therapy, 31, (5), 2014, p512-538Journal Article, 2014, DOI
  • Chong, S.G., Mitchell, P., Fabre, A., McDonnell, T.J., Recurrent pneumothoraces in a 65-year-old female: An unusual case of cystic lung disease, European Respiratory Review, 23, (132), 2014, p271-272Journal Article, 2014, DOI
  • Pallin, M., Walsh, S., O'Driscoll, M.F., Murray, C., Cahalane, A., Brown, L., Carter, M., Mitchell, P., McDonnell, T.J., Butler, M.W., Overwhelming support among urban Irish COPD patients for lung cancer screening by low-dose CT scan, Lung, 190, (6), 2012, p621-628Journal Article, 2012, DOI
  • O'Neill, A.C., McCarthy, C., Ridge, C.A., Mitchell, P., Hanrahan, E., Butler, M., Keane, M.P., Dodd, J.D., Rapid needle-out patient- rollover time after percutaneous CT-guided transthoracic biopsy of lung nodules: Effect on pneumothorax rate, Radiology, 262, (1), 2012, p314-319Journal Article, 2012, DOI
  • Slattery, E., Mitchell, P., Mulcahy, H.E., Cigarette smoking in Crohn's disease: Can we do more?, Journal of Crohn's and Colitis, 5, (5), 2011, p505Journal Article, 2011, DOI
  • Lugogo, N., Liu, M.C., Pavord, I., Mitchell, P.D., Smith, S.G., Mallett, S., Albers, F.C., Bradford, E.S., Yancey, S.W., Bel, E.H., Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis, Journal of Allergy and Clinical Immunology: In Practice, 9, (9), 2021, p3506-3509.e3Journal Article, 2021, DOI
  • Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., 2021 Canadian Thoracic Society Guideline"A focused update on the management of very mild and mild asthma, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021Journal Article, 2021, DOI
  • Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021Journal Article, 2021, DOI
  • Upham, J.W., Le Lievre, C., Jackson, D.J., Masoli, M., Wechsler, M.E., Price, D.B., Mansur, A., Detoraki, A., Altraja, A., James, A., Nanzer-Kelly, A., Côté, A., Menzies-Gow, A., Papaioannou, A., Cheffins, A.-M., Bourdin, A., Mahboub, B., Lipworth, B., Celis-Preciado, C.A., Torres-Duque, C., Bucca, C., Porsbjerg, C., Ulrik, C., Corrigan, C., Taube, C., Farah, C., Katelaris, C., Langton, D., Ryan, D., Larenas-Linnemann, D., Zervas, E., Heffler, E., Hoyte, F., Puggioni, F., Christoff, G., Canonica, G.W., Carpagnano, G.E., Guida, G., Katsoulotos, G., Brusselle, G., Rupani, H., Jersmann, H., Clifton, I., Dhariwal, J., Fingleton, J., Duke, J., Rimmer, J., Douglass, J., Fonseca, J., van Boven, J., Corless, J., Harrington, J., Maspero, J., Miguel, J.L., Pipatvech, K., Kenny, K., Chapman, K., Kostikas, K., Lehtimäki, L., Chung, L.P., Heaney, L., Hang, L.-W., Boulet, L.-P., Perez-de-Llano, L., Ricciardi, L., Idrees, M., Milanese, M., Conte, M.E., Costantino, M.T., Siyue, M.K., Fitzgerald, M., Hew, M., Peters, M., Tsai, M.-J., Patel, M., Khan, M.H., Sadatsafavi, M., Al-Ahmad, M., Yacoub, M.-R., De Gennaro, M., Radhakrishna, N., Hanania, N.A., Papadopoulos, N., Lugogo, N., Linaker, N., Crimi, N., Dennison, P., Nair, P., Mitchell, P.D., O'Byrne, P., Pfeffer, P., Kauppi, P., Hughes, P., Middleton, P., Wark, P., Bardin, P., Fu, P.-K., Akuthota, P., Chaudhuri, R., Campos, R., Al-Lehebi, R., Parente, R., Francisco, R., Wenzel, S., Pierachille, S., Pawar, S., Loukides, S., Fowler, S., Mackenzie, T., Brown, T., Lee Tan, T., Björnsdóttir, U., McDonald, V., Lawriwskyj, V., Backer, V., Vasileva, V., Chien, Y.-C., Harrington, Z., Defining a Severe Asthma Super-Responder: Findings from a Delphi Process, Journal of Allergy and Clinical Immunology: In Practice, 2021Journal Article, 2021, DOI
  • Kaplan, A., Mitchell, P.D., Cave, A.J., Gagnon, R., Foran, V., Ellis, A.K., Effective asthma management: Is it time to let the AIR out of SABA?, Journal of Clinical Medicine, 9, (4), 2020Journal Article, 2020, DOI
  • Mitchell PD, Olaniyi J, Buckley C, Donnelly SC., Long COVID syndrome and the lung-How long will it last?, QJM : monthly journal of the Association of Physicians, 2022Journal Article, 2022, DOI
  • Mitchell P.D., Buckley C., Subramaniam A., Crowther S., Donnelly S.C., Elevated serum ACE levels in patients with post-acute COVID-19 syndrome, QJM : monthly journal of the Association of Physicians, 115, (10), 2022, p651 - 652, p651-652Journal Article, 2022, DOI
  • Ellis, A.K., Foran, V., Kaplan, A., Mitchell, P.D., Clarifying SABA overuse: Translating Canadian Thoracic Society guidelines into clinical practice, Allergy, Asthma and Clinical Immunology, 18, (1), 2022Journal Article, 2022, DOI
  • Atwood, C.E., Bhutani, M., Ospina, M.B., Rowe, B.H., Leigh, R., Deuchar, L., Faris, P., Michas, M., Mrklas, K.J., Graham, J., Aceron, R., Damant, R., Green, L., Hirani, N., Longard, K., Meyer, V., Mitchell, P., Tsai, W., Walker, B., Stickland, M.K., Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care Coordinator: A Randomized Clinical Trial, Chest, 162, (2), 2022, p321-330Journal Article, 2022, DOI
  • Whetstone CE, Ranjbar M, Cusack RP, Al-Sajee D, Omer H, Alsaji N, Ho T, Duong M, Mitchell P, Satia I, Keith P, Xie Y, MacLean J, Sommer DD, Gauvreau GM, Protein expression of SARS-CoV-2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge., Allergy, 2023Journal Article, 2023, DOI
  • Pfeffer, P.E., Ali, N., Murray, R., Ulrik, C., Tran, T.N., Maspero, J., Peters, M., Christoff, G.C., Sadatsafavi, M., Torres-Duque, C.A., Altraja, A., Lehtimäki, L., Papadopoulos, N., Salvi, S., Costello, R.W., Cushen, B., Heffler, E., Iwanaga, T., Al-Ahmad, M., Larenas-Linnemann, D., Kuna, P., Fonseca, J.A., Al-Lehebi, R., Rhee, C.K., Perez-de-Llano, L., Perng Steve, D.-W., Mahboub, B., Wang, E., Goh, C., Lyu, J., Newell, A., Alacqua, M., Belevskiy, A.S., Bhutani, M., Bjermer, L., Bjornsdottir, U., Bourdin, A., Bulow, A.V., Busby, J., Canonica, G.W., Cosio, B.G., Dorscheid, D.R., Muñoz-Esquerre, M., FitzGerald, J.M., Gil, E.G., Gibson, P.G., Heaney, L.G., Hew, M., Hilberg, O., Hoyte, F., Jackson, D.J., Koh, M.S., Ko, H.-K.B., Lee, J.H., Lehmann, S., Chaves Loureiro, C., Lúðvíksdóttir, D., Menzies-Gow, A.N., Mitchell, P., Papaioannou, A.I., Popov, T.A., Porsbjerg, C.M., Salameh, L., Sirena, C., Taillé, C., Taube, C., Tohda, Y., Wechsler, M.E., Price, D.B., Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both, Allergy: European Journal of Allergy and Clinical Immunology, 2023Journal Article, 2023, DOI
  • Menzies-Gow, A., Wechsler, M.E., Brightling, C.E., Korn, S., Corren, J., Israel, E., Chupp, G., Bednarczyk, A., Ponnarambil, S., Caveney, S., Almqvist, G., Go""bek, M., Simonsson, L., Lawson, K., Bowen, K., Colice, G., Hetzel, J.L., Fiterman, J., Souza Machado, A., Antila, M.A., Lima, M.A., Minamoto, S.E.T., Blanco, D.C., Bezerra, P.G.D.M., Houle, P.-A., Lemiere, C., Melenka, L.S., Leigh, R., Mitchell, P., Anees, S., Pek, B., Chouinard, G., Cheema, A.S., Yang, W.H.-C., Philteos, G., Chanez, P., Bourdin, A., Devouassoux, G., Taille, C., De Blay, F., Leroyer, C., Beurnier, A., Garcia, G., Girodet, P.-O., Blanc, F.-X., Magnan, A., Wanin, S., Just, J., Linde, R., Zielen, S., Förster, K., Geßner, C., Jandl, M., Buhl, R.O., Kornmann, M.O., Linnhoff, A., Ludwig-Sengpiel, A., Ehlers, M., Schmoller, T., Steffen, H., Hoffmann, M., Kirschner, J., Schmidt, O., Welte, T., Temme, H., Wand, O., Bar-Shai, A., Izbicki, G., Berkman, N., Fink, G., Shitrit, D., Adir, Y., Kuna, P., Rewerska, B., Pisarczyk-Bogacka, E., Kurbacheva, O., Mikhailov, S.L., Vasilev, M., Emelyanov, A., Wali, S., Albanna, A., van Zyl-Smit, R., Abdullah, I., Bernhardi, D., Hoosen, F., Irusen, E., Kalla, I., Lakha, D., Mitha, E., Naidoo, V., Nell, H., Padayachee, T., Reddy, J., Petrick, F., van der Walt, E., Vawda, Z.F.A., Park, H.-S., Lee, S.H., Kim, M.-K., Park, J.-W., Cho, Y.S., Lee, B.J., Chang, Y.-S., Park, C.-S., Lee, K.H., Lee, S.Y., Yoon, H., Sohn, K.H., Park, M.J., Min, K.H., Cho, Y.J., Park, H.K., Lee, Y., Lee, J., Sheu, C.-C., Tu, C.-Y., Lee, K.-Y., Bavbek, S., Gemicioglu, B., Ediger, D., Kalkan, I.K., Makieieva, N., Ostrovskyy, M., Dytyatkovs'ka, Y., Mostovoy, Y.M., Lebed, K., Yakovenko, O., Adams, A., Mooring, T., Torres Jr, L., Sexton, M., Thompson, E., Bernstein, J.A., Lisi, P., Chappel, C.M., Cole, J., Greenwald, G.I., Jones, C., Klein, R.M., Pham, D.N., Spangenthal, S., Weinstein, S.F., Windom, H.H., Kao, N.L., Leong, M.A., Mehta, V., Moore, W.C., Bhat, S., Aish, B., Meltzer, S.M., Moss, M.H., Kerwin, E.M., Delgado, J.P., Lucksinger, G.H., Thompson, C.A., Alpizar, S.A., Vadgama, S.V., Zafar, Z., Jacobs, J.S., Lugogo, N.J., Jain, N., Sher, L.D., Andrawis, N.S., Fuentes, D., Boren, E.J., Gonzalez, E.G., Talreja, N., Durrani, S.S., Sekhsaria, S., DeLeon, S., Shukla, M., Totszollosy Tarpay, M.M., Fakih, F., Hudes, G., Tillinghast, J.P., Korenblat, P.E., Shenoy, K., Que, L., Kureishy, S.A., Umeh, F.C., Nguyen, V.N., Chu, H.T., Nguyen, T.T.D., Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study, The Lancet Respiratory Medicine, 11, (5), 2023, p425-438Journal Article, 2023, DOI
  • Busby, J., Price, D., Al-Lehebi, R., Bosnic-Anticevich, S., van Boven, J.F.M., Emmanuel, B., Fitzgerald, J.M., Gaga, M., Hansen, S., Hew, M., Iwanaga, T., Linnemann, D.L., Mahboub, B., Mitchell, P., Morrone, D., Pham, J., Porsbjerg, C., Roche, N., Wang, E., Eleangovan, N., Heaney, L.G., Impact of socioeconomic status on adult patients with asthma: A population-based cohort study from uk primary care, Journal of Asthma and Allergy, 14, 2021, p1375-1388Journal Article, 2021, DOI
  • Gail Gauvreau, Roma Sehmi, J FitzGerald, Richard Leigh, Donald Cockcroft, Beth Davis, Irvin Mayers, Louis-Philippe Boulet, Brittany Salter, Ruth Cusack, Imran Satia, Kieran Killian, Patrick Mitchell, Viktoria Werkstrom, Tomasz Durzynski, Kathryn Shoemaker, Rohit Katial, Maria Jison, Paul Newbold, Paul O'Byrne, The effect of benralizumab on allergen-induced responses in subjects with mild allergic asthma, Journal of Allergy and Clinical Immunology, 147, (2), 2021, p157-Journal Article, URL
  • Anti-IgE and Biologic Approaches for the Treatment of Asthma Mitchell PD, El-Gammal A, O'Byrne PM. Handbook of Experimental Pharmacology. Pharmacology and therapeutics of asthma and COPD. Springer, United Kingdom., Pharmacology and Therapeutics of Asthma and COPD, 1, United Kingdom, Springer , 2017, 131 - 152ppBook, URL

Research Expertise

  • Title
    Implication of the upper respiratory tract microbiota in long-COVID patients and the role of the new emerging beneficial bacterium Dolosigranulum pigrum.
    Summary
    COVID-19 is a new disease with high mortality caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and responsible for the ongoing global pandemic. Different studies performed over the past year demonstrated a link between COVID-19 severity and the nasopharynx microbiota, however, studies investigating changes in microbiome components with regards to the aftermath of the disease, such as full recovery or development of long-term COVID-19 symptoms are still lacking. This project aims to fill this knowledge gap by performing an in-depth characterization of microbial communities associated with the upper respiratory tract of patients that developed long-term COVID-19 symptoms and those who presented full recovery using metagenomics and state-of-art statistical analysis. In addition, the protective role of the bacterium Dolosigranulum pigrum against COVID-19 will also be investigated through genomics and immunoassay procedures. This proposal will advance our knowledge and help the scientific community by shedding light on the composition of the nasopharynx microbiota and its role in patients' recovery. By investigating the genetic features of a new emerging beneficial bacterium of the upper respiratory tract, we aim at elucidating its role for the host and probiotic potential against severe and long-term SARS-CoV-2 outcome.

Immunity and Infection (including Rheumatology & Inflammatory disease), Immunity and Infection (including Rheumatology & Inflammatory disease), Respiratory Medicine, Respiratory Medicine,

Recognition

  • Austine Mehigan Award for Teaching Excellence St Vincents University Hospital 6/2011
  • Member of the European Respiratory Society
  • Member of the Royal College of Physicians of Ireland
  • Royal College of Physicians of Ireland
  • Fellow of the Royal College of Physicians of Ireland
  • Member of the Irish Thoracic Society
  • Invited reviewer of the following journals: Thorax BMJ Open Chest European Respiratory Journal PLOS One Journal of Thoracic Disease Respiratory Research 6/6/2016
  • Invited reviewer of the following journals: Thorax BMJ Open Chest European Respiratory Journal PLOS One Journal of Thoracic Disease Respiratory Research 6/6/2016