Medicine

Contact Us School of Medicine
Level 1
Trinity Biomedical Sciences Institute
Trinity College
152-160 Pearse Street
Dublin 2

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medadmin@tcd.ie
Professor Niamh O'Connell

Professor Niamh O'Connell

Clinical Professor, Clinical Medicine

3531 4103521https://www.stjames.ie/services/hope/nationalcoagulationcentre/

Publications and Further Research Outputs

  • C Logan, J Kavanagh, N O'Connell, N McEniff, JM Ryan, M Guiney, K Ryan, O Seery, J O'Donnell, B White., Out of sight, out of mind? An audit which proposes a follow-up and management pathway for Inferior Vena Cava Filters. , Thrombosis, MS No 483870, 2016, pdoi:10.1155/2016/6538456Journal Article, 2016
  • Lavin M, Brophy T.M, Rawley O, O'Sullivan J.M, Hayden P.J, Browne P.V, Ryan K, O'Connell N, O'Donnell J.S, Lenalidomide as a novel treatment for refractory acquired von Willebrand syndrome associated with monoclonal gammopathy, Journal of Thrombosis and Haemostasis, 14, (6), 2016, p1200 - 1205Journal Article, 2016, DOI , URL
  • Lavin, M. and Ryan, K. and White, B. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., A role for intravenous immunoglobulin in the treatment of Acquired Von Willebrand Syndrome associated with IgM gammopathy, Haemophilia, 2017, pe22-e25Journal Article, 2017, DOI , URL
  • Lavin, M. and Kavanagh, J. and Beddy, P. and O'Connell, N.M. and O'Donnell, J.S., Recurrent lower limb venous thrombosis associated with a congenitally absent infrarenal inferior vena cava, QJM, 109, (1), 2016, p57Journal Article, 2016, DOI , URL
  • Lavin, M. and Jenkins, P.V. and Keenan, C. and White, B. and Betts, D.R. and O'Donnell, J.S. and O'Connell, N.M., X-linked moyamoya syndrome associated with severe haemophilia A, Haemophilia, 22, (1), 2016, pe51-e54Journal Article, 2016, DOI , URL
  • Lavin, M. and Jenkins, P.V. and Healy, M.L. and Byrne, M. and O'Connell, N.M. and O'Donnell, J.S., Age-related factor IX correction in symptomatic female carriers with haemophilia B Leyden, Haemophilia, 21, (6), 2015, pe498-e500Journal Article, 2015, DOI , URL
  • Appleby, N., Groarke, E., Crowley, M., Wahab, F. A., McCann, A. M., Egan, L., Gough, D., McMahon, G., O'Donghaile, D., O'Keeffe, D., O'Connell, N., Reversal of warfarin anticoagulation using prothrombin complex concentrate at 25 IU kg"1 : results of the RAPID study, Transfusion Medicine, 27, (1), 2017, p66-71Journal Article, 2017, DOI
  • Y. L. Woo, B. White, R. Corbally, M. Byrne, N. O'Connell, E. O'Shea, B. L. Sheppard, J. Bonnar and O. P. Smith, von Willebrand's disease: an important cause of dysfunctional uterine bleeding, Blood coagulation & fibrinolysis, 13, (2), 2002, p89-93Journal Article, 2002, URL
  • N. O'Connell, J. Chen, M. Byrne, E. O'Shea, H. Smyth and O. P. Smith, Massive pseudotumour resection with recombinant factor VIIa (NovoSeven) cover, British journal of haematology, 116, (3), 2002, p645-8Journal Article, 2002, URL
  • N. O'Connell, C. Mc Mahon, J. Smith, K. Khair, I. Hann, R. Liesner and O. P. Smith, Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors, British journal of haematology, 116, (3), 2002, p632-5Journal Article, 2002, URL
  • N. O'Connell, N. Gardiner, C. Duggan, H. Enright, M. J. Kennedy, S. R. McCann, P. A. Daly and P. V. Browne, Effective progenitor cell mobilization in lymphoproliferative disorders using ifosfamide, epirubicin and etoposide (IEV), European journal of haematology Supplementum, (64), 2001, p33-6Journal Article, 2001, URL
  • Fogarty, Helen, Townsend, Liam, Ni Cheallaigh, Cliona, Bergin, Colm, Martin"Loeches, Ignacio, Browne, Paul, Bacon, Christopher L., Gaule, Richard, Gillett, Alexander, Byrne, Mary, Ryan, Kevin, O'Connell, Niamh, O'Sullivan, Jamie M., Conlon, Niall, O'Donnell, James S., More on COVID"19 coagulopathy in Caucasian patients, British Journal of Haematology, 189, (6), 2020, p1060-1061Journal Article, 2020, DOI
  • Townsend L, Fogarty H, Dyer A, Martin-Loeches I, Bannan C, Nadarajan P, Bergin C, O' Farrelly C, Conlon N, Bourke NM, Ward SE, Byrne M, Ryan K, O' Donnell JS, Prolonged elevation of D-dimer Levels in Convalescent COVID-19 patients is Independent of the Acute Phase Response., Journal of thrombosis and haemostasis : JTH, 2021Journal Article, 2021
  • Kennedy M, O'Gorman P, Monaghan A, Lavin M, O'Mahony B, O'Connell N.M, O'Donnell J.S, Turecek P.L, Gormley J, A systematic review of physical activity in people with haemophilia and its relationship with bleeding phenotype and treatment regimen, Haemophilia, 27, (4), 2021, p544 - 562Journal Article, 2021, DOI , URL
  • Helen Fogarty, Liam Townsend, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Paul Browne, Christopher L Bacon, Richard Gaule, Alexander Gillett, Mary Byrne, Kevin Ryan, Niamh O'Connell, Jamie M O'Sullivan, Niall Conlon, James S O'Donnell, COVID 19 coagulopathy in caucasian patients, British Journal of Haematology, 89, (6), 2020, p1044 - 1049Journal Article, 2020
  • O'Reilly MA, McHale C, Almazmi A, Hameed A, Benjamin D, O'Connell N, Murphy P, Quinn J, Thornton P, O'Gorman P, Frankova H, Sargent J, Verburgh E, McHugh J, Evans P, Enright H., A 5-day: the favourable way?, Annals of hematology, 93, (9), 2014, p1619-1620Journal Article, 2014, DOI
  • O'Reilly MA, McHale C, Almazmi A, Hameed A, Benjamin D, O'Connell N, Murphy P, Quinn J, Thornton P, O'Gorman P, Frankova H, Sargent J, Verburgh E, McHugh J, Evans P, Enright H., A 5-day outpatient regimen of azacitidine is effective and well tolerated in patients with acute myeloid leukemia unsuitable for intensive chemotherapy., Leukemia & lymphoma, 55, (12), 2014, p2950-2951Journal Article, 2014, DOI
  • Basic principles of coagulation in, editor(s)Denise O'Shaughnessy Michael Makris David Lillicrap , Practical Haemostasis, Oxford University Press, 2004, [Niamh O'Connell]Book Chapter, 2004
  • Haematological emergencies in, editor(s)R.A.J.Spence P.Johnston , Oncological Emergencies, Oxford University Press, 2002, [Niamh O'Connell, Shaun R. McCann]Book Chapter, 2002
  • Steven W. Pipe, Michael Recht, Nigel S. Key, Frank W.G. Leebeek, Giancarlo Castaman, Susan U. Lattimore, Paul Van Der Valk, Kathelijne Peerlinck, Michiel Coppens, Niamh O'Connell, John Pasi, Peter Kampmann, Karina Meijer, Annette von Drygalski, Guy Young, Cedric Hermans, Jan Astermark, Robert Klamroth, Richard S. Lemons, Nathan Visweshwar, Shelley Crary, Rashid Kazmi, Emily Symington, Miguel A. Escobar, Esteban Gomez, Rebecca Kruse-Jarres, Adam Kotowski, Doris Quon, Michael Wang, Allison P. Wheeler, Eileen K Sawyer, Stephanie Verweij, Valerie Colletta, Naghmana Bajma, Robert Gut, Wolfgang A. Miesbach, First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies, The American Society of Hematoloy, Dec 2020, 2020Oral Presentation, 2020
  • O'Donovan M, Bergin C, Quinn E, Singleton E, Roche S, Benson J, Bird R, Byrne M, Duggan C, Gilmore R, Ryan K, O'Donnell JS, O'Connell NM, Real-world outcomes with recombinant factor IX Fc fusion protein (rFIXFc) prophylaxis: Longitudinal follow-up in a national adult cohort., Haemophilia : the official journal of the World Federation of Hemophilia, 2021Journal Article, 2021
  • Kempton C, Trask P, Parnes A, Niggli M, Campinha-Bacote A, U Callaghan M, O'Connell N, Paz-Priel I, Mahlangu JN, Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors., Haemophilia : the official journal of the World Federation of Hemophilia, 2021Journal Article, 2021
  • Doherty D, Lavin M, O'Sullivan JM, Ryan K, O'Connell NM, Dougall A, Byrne M, Rafferty M, Doyle MM, Di Paola J, James PD, O'Donnell JS, Management of elective procedures in low von Willebrand factor patients in the LoVIC study., Journal of thrombosis and haemostasis : JTH, 2021Journal Article, 2021
  • O'Donovan M, Buckley C, Benson J, Roche S, McGowan M, Parkinson L, Byrne P, Rooney G, Bergin C, Walsh D, Bird R, McGroarty F, Fogarty H, Smyth E, O'Connell NM, Telehealth for delivery of haemophilia comprehensive care during the COVID-19 pandemic., Haemophilia : the official journal of the World Federation of Hemophilia, 2020Journal Article, 2020
  • Mumford AD, Ackroyd S, Alikhan R, Bowles L, Chowdary P, Grainger J, Mainwaring J, Mathias M, O'Connell N, BCSH Committee, Guideline for the diagnosis and management of the rare coagulation disorders: a United Kingdom Haemophilia Centre Doctors' Organization guideline on behalf of the British Committee for Standards in Haematology., British journal of haematology, 2014Journal Article, 2014
  • O'Donnell DM, O'Connell NM, O'Donnell JS, Oral rivaroxaban for pulmonary embolism., The New England journal of medicine, 2012Journal Article, 2012
  • Qasim A, Duggan M, O'Connell N, O'Driscoll A, Clinical conditions and patient factors significantly influence diagnostic utility of D-dimer in venous thromboembolism., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2009Journal Article, 2009
  • O'Connell NM, Riddell AF, Pascoe G, Perry DJ, Lee CA, Recombinant factor VIIa to prevent surgical bleeding in factor XI deficiency., Haemophilia : the official journal of the World Federation of Hemophilia, 2008Journal Article, 2008
  • Kadir RA, Kingman CE, Chi C, O'connell NM, Riddell A, Lee CA, Economides DL, Screening for factor XI deficiency amongst pregnant women of Ashkenazi Jewish origin., Haemophilia : the official journal of the World Federation of Hemophilia, 2006Journal Article, 2006
  • Hayden PJ, O'Connell NM, O'Brien DA, O'Rourke P, Lawlor E, Browne PV, The value of autofluorescence as a diagnostic feature of acute promyelocytic leukemia., Haematologica, 2006Journal Article, 2006
  • Saunders RE, O'Connell NM, Lee CA, Perry DJ, Perkins SJ, Factor XI deficiency database: an interactive web database of mutations, phenotypes, and structural analysis tools., Human mutation, 2005Journal Article, 2005
  • O'Connell NM, Saunders RE, Lee CA, Perry DJ, Perkins SJ, Structural interpretation of 42 mutations causing factor XI deficiency using homology modeling., Journal of thrombosis and haemostasis : JTH, 2005Journal Article, 2005
  • Grace A, O'Connell N, Byrne P, Prendiville W, O'Donnell R, Royston D, Walsh CB, Leader M, Kay E, Malignant lymphoma of the cervix. An unusual presentation and a rare disease., European journal of gynaecological oncology, 1999Journal Article, 1999
  • Aguila S, Lavin M, Dalton N, Patmore S, Chion A, Trahan GD, Jones KL, Keenan C, Brophy TM, O'Connell NM, Ryan K, Byrne M, Nolan M, Patel A, O'Donnell JS, Increased galactose expression and enhanced clearance in patients with low von Willebrand factor., Blood, 2019Journal Article, 2019, DOI
  • O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy DF, Laffan MA, Smith OP, Recombinant FVIIa in the management of uncontrolled hemorrhage., Transfusion, 2003Journal Article, 2003, DOI
  • Laffan M, O'Connell NM, Perry DJ, Hodgson AJ, O'Shaughnessy D, Smith OP, Analysis and results of the recombinant factor VIIa extended-use registry., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003Journal Article, 2003, DOI
  • O'Connell NM, Factor XI deficiency--from molecular genetics to clinical management., Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2003Journal Article, 2003, DOI
  • Salomon O, Zivelin A, Livnat T, Dardik R, Loewenthal R, Avishai O, Steinberg DM, Rosove MH, O'Connell N, Lee CA, Seligsohn U, Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency., Blood, 2003Journal Article, 2003, DOI
  • Doherty D, Singleton E, Byrne M, Ryan K, O'Connell NM, O'Donnell JS, Lavin M, Missed at first Glanz: Glanzmann thrombasthenia initially misdiagnosed as Von Willebrand Disease., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018Journal Article, 2018, DOI
  • Lavin M, Aguila S, Dalton N, Nolan M, Byrne M, Ryan K, White B, O'Connell NM, O'Sullivan JM, Di Paola J, James PD, O'Donnell JS, Significant gynecological bleeding in women with low von Willebrand factor levels., Blood advances, 2018Journal Article, 2018, DOI
  • Kevane B, O'Connell N, The current and future role of plasma-derived clotting factor concentrate in the treatment of haemophilia A., Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, 2018Journal Article, 2018, DOI
  • Fogarty H, Doyle MM, Campbell R, Keenan C, White B, Ryan K, O'Donnell JS, Slevin J, O'Keeffe D, O'Connell NM, Lavin M, Management of combined factor V and factor VIII deficiency in pregnancy., Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2018Journal Article, 2018, DOI
  • Lavin M, Aguila S, Schneppenheim S, Dalton N, Jones KL, O'Sullivan JM, O'Connell NM, Ryan K, White B, Byrne M, Rafferty M, Doyle MM, Nolan M, O'Donnell JS, Novel insights into the clinical phenotype and pathophysiology underlying low VWF levels., Blood, 2017Journal Article, 2017, DOI
  • Grogan A, Coughlan M, Prizeman G, O'Connell N, O'Mahony N, Quinn K, McKee G, The patients' perspective of international normalized ratio self-testing, remote communication of test results and confidence to move to self-management., Journal of clinical nursing, 2017Journal Article, 2017, DOI
  • Niamh M. O{', Acquired Factor Xiii Deficiency: An Uncommon But Easily Missed Cause Of Severe Bleeding, Irish medical journal, 2018Journal Article, 2018
  • Niamh M. O{', Allogeneic Hematopoietic Stem Cell Transplantation for a BCR-FGFR1 Myeloproliferative Neoplasm Presenting as Acute Lymphoblastic Leukemia., Case reports in hematology, 2012Journal Article, 2012, DOI , URL
  • Niamh M. O{', Childhood refractory autoimmune haemolytic anaemia: is there a role for anti-CD20 therapy (rituximab)?, British journal of haematology, 2002Journal Article, 2002, DOI , URL
  • Niamh M. O{', Fatal Pancreatic Necrosis after Pregnancy-Associated Thrombotic Thrombocytopenic Purpura., Hematology (Amsterdam, Netherlands), 2001Journal Article, 2001, DOI , URL
  • Groarke E, O'Connell N, Practical management of venous thromboembolism in patients with cancer, Cancer Professional, 11, (1), 2017, p14 - 16Journal Article
  • Bakhai A, Lip GH, McCormack T, Rose P, Eames M, O'Connell N, Harrison-Tiffin N, Fortes-Mayer G, Fitzmaurice D, Fay M, Defining consensus in anticoagulation service delivery for patients with atrial fibrillation, Prescriber, 2012Journal Article
  • A. McCashin, Fact or Fiction?, Poverty Today [Combat Poverty Agency magazine], 1996, p11 - 12Journal Article

Recognition

  • The P.F. Fitzpatrick Prize in Social and Preventive medicine 1993
  • The Dr. Henry Hutchinson Stewart Scholarship in Anatomy 1991
  • The R.G.G. Barry prize in Paediatrics 1994
  • The James M. O'Donovan Prize 1994
  • University College Cork Scholarships 1989, 1990,1991,1993
  • The Pfizer Gold Medal in Psychiatry 1993
  • The Charles Medals in Anatomy and Physiology 1991
  • The Blayney Prize 1994
  • The European Association for Haemophilia and Allied Disorders Current
  • The Haematology Association of Ireland Current
  • The Irish Haematology Society Current
  • The International Society for Thrombosis and Haemostasis Current
  • The U.K. Haemophilia Centre Doctors Organisation Current
  • The World Federation of Haemophilia Current
  • Member of the National Haemophilia Council July 2018
  • Grant application reviewer for the UK MRC 2021
  • Grant application reviewer for the UK MRC 2021
  • Member of the Medical and Scientific Advisory Board of the Irish Blood Transfusion service 2010
  • Chair of the Haemophilia Product Selection and Monitoring advisory Board February 2018
  • Member of the Medical and Scientific Advisory Board of the Irish Blood Transfusion service 2010
  • Member of the committee of the Haematology association of Ireland 2005
  • Journal Reviewer (Haemophilia, Clinical and Applied Thrombosis and Haemostasis, American Journal of Hematology, Anesthesia and Analgesia Irish Medical Journal) 2011
  • Member of the committee of the Haematology association of Ireland 2005
  • Member of the National Haemophilia Council July 2018
  • Advisor to the National Immunisation Advisory Committee 2021
  • Advisor to the National Immunisation Advisory Committee 2021
  • Journal Reviewer (Haemophilia, Clinical and Applied Thrombosis and Haemostasis, American Journal of Hematology, Anesthesia and Analgesia Irish Medical Journal) 2011
  • Chair of the Irish Haematology Society Coagulation Special Interest group November 2019
  • Chair of the Haemophilia Product Selection and Monitoring advisory Board February 2018
  • Chair of the Irish Haematology Society Coagulation Special Interest group November 2019