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Dr. Natalia Munoz-Wolf

Dr. Natalia Munoz-Wolf

Research Assistant Professor, Clinical Medicine

https://www.respiratoryimmunology.com/

Biography

Dr Natalia Muñoz-Wolf was appointed as Research Assistant Professor at the Department of Clinical Medicine - School of Medicine, Trinity College Dublin (TCD) in 2020. She was an awardee of the 2019 Emerging Investigator Awards funded by the Irish Health Research Board. She leads the Translational Respiratory Immunology Lab (TRIL) base in the School of Medicine, Trinity Biomedical Sciences Institute, one of the flagship institutes in Trinity College Dublin. The main research focus of the Translational Respiratory Immunology Lab is to unveil the role of gut microbiome and gut derived metabolites on chronic lung conditions (mainly Chronic Obstructive Pulmonary Disease (COPD)) and respiratory infections. Her lab also focuses on harnessing the power of the microbiome and the gut-lung axis of immune regulation to enhance efficacy of injectable and mucosal vaccines against Streptococcus pneumoniae. Her lab work closely with our clinical partners at the Department of Clinical Medicine in Tallaght University Hospital in Dublin and collaborators in the School of Biochemistry & Immunology TCD, University College Cork and Maynooth University in Ireland as well as international partners in the University of Uruguay. Dr Muñoz-Wolf earned her Biochemistry degree in the School of Sciences, University of Uruguay which focused on immunomodulation by helminths. She completed a 5-year PhD in Chemistry which she carried out at the Department of Biotechnology, University of La Republica - Uruguay and Institut Pasteur Lille - France. Her PhD focused on the use of microbial-derived molecules as therapeutics and vaccines adjuvants for pneumococcal pneumonia. In 2013 she joined the Adjuvant Research Group led by Prof. Ed Lavelle at Trinity College to complete her postdoctoral studies. During her postdoc she addressed the mode of action of particulate adjuvants for optimisation of T cell responses. In parallel she continued to develop her research on lung diseases for which she received two prestigious awards: The 2017 Thomas Mitchell Medal of Excellence awarded by the IRC for being the highest ranked postdoctoral fellow in Sciences, Technology, Engineering and Mathematics and the 2018 Fellowship Award by the Federation of European Microbiological Societies. She established her independent lab, the Translational Respiratory Immunology Lab (TRIL) at the School of Medicine, TCD in 2019. She has co-supervised several undergraduate, PhD and master"s research projects in immunology at TCD. She contributed as a lecturer in the Infection and Disease module of the Immunology degree and Postgraduate courses in TCD, and is a member of the Executive Board and Outreach Committee of the Irish Society for Immunology where she serves as the Communications Lead for the Society.

Publications and Further Research Outputs

  • Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379Journal Article, 2016, URL , TARA - Full Text
  • Carroll, E.C., Jin, L., Mori, A., Muñoz-Wolf, N., Oleszycka, E., Moran, H.B.T., Mansouri, S., McEntee, C.P., Lambe, E., Agger, E.M., Andersen, P., Cunningham, C., Hertzog, P., Fitzgerald, K.A., Bowie, A.G., Lavelle, E.C., The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons, Immunity, 44, (3), 2016, p597 - 608Journal Article, 2016, DOI
  • Munoz-Wolf, N. and Lavelle, E.C., Hippo interferes with antiviral defences, Nature Cell Biology, 19, (4), 2017, p267-269Journal Article, 2017, DOI , URL
  • The Role of Inflammasomes in Adjuvant-Driven Humoral and Cellular Immune Responses in, editor(s)Virgil Schijns and Derek O'Hagan , Immunopotentiators in Modern Vaccines , 2016, pp23-42 , [Munoz-Wolf, N., McCluskey, S. and Lavelle, E.C.]Book Chapter, 2016, DOI , URL
  • Oleszycka, E., McCluskey, S., Sharp, F.A., Muñoz-Wolf, N., Hams, E., Gorman, A.L., Fallon, P.G. and Lavelle EC., The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses., European Journal of Immunology, 2018, 705-715Journal Article, 2018, DOI
  • Munoz-Wolf, N. and Lavelle, E.C., A Guide to IL-1 family cytokines in adjuvanticity, FEBS Journal, 285, (13), 2018, p2377 - 2401Journal Article, 2018, DOI , URL
  • O'Grady, K., Hearnden, C.C.H., Bento, D., Oleszycka, E., Andersen, P., Muñoz-Wolf, N. and Lavelle, E.C. , IL-33 is a negative regulator of vaccine-induced antigen-specific cellular immunity, The Journal of Immunology, 2019Journal Article, 2019
  • Emma B. O'Connor, Natalia Muñoz-Wolf, Gemma Leon, Ed C. Lavelle, Kingston H. G. Mills, Patrick T. Walsh and Richard K. Porter, UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation, PLoS ONE, 15, (11), 2020, pe02-Journal Article, 2020, TARA - Full Text
  • Innate immune receptors in, editor(s)Pablo Pelegrin and Francesco Di Virgilio , Nod Like Receptors, Springer, 2016, pp1-43 , [Muñoz-Wolf, N and Lavelle, E.C. ]Book Chapter, 2016
  • Carty, M. and Kearney, J. and Shanahan, K.A. and Hams, E. and Sugisawa, R. and Connolly, D. and Doran, C.G. and Muñoz-Wolf, N. and GÃ"rtler, C. and Fitzgerald, K.A. and Lavelle, E.C. and Fallon, P.G. and Bowie, A.G., Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM, Immunity, 50, (6), 2019, p1412-1424.e6Journal Article, 2019
  • Sinéad Kenealy∗, Joan Manils∗, Mathilde Raverdeau Natalia Munoz-Wolf, Gillian Barber, Alex Liddicoat, Ed C.Lavelle Emma M.Creagh , Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced Psoriasis, Journal of Investigative Dermatology, 2019, p2389 - 2393Journal Article, 2019, DOI , TARA - Full Text
  • Hackett, E.E., Charles-Messance, H., O'Leary, S.M., Gleeson, L.E., Muñoz-Wolf, N., Case, S., Wedderburn, A., Johnston, D.G.W., Williams, M.A., Smyth, A., Ouimet, M., Moore, K.J., Lavelle, E.C., Corr, S.C., Gordon, S.V., Keane, J., Sheedy, F.J., Mycobacterium tuberculosis Limits Host Glycolysis and IL-1ß by Restriction of PFK-M via MicroRNA-21, Cell Reports, 30, (1), 2020, p124-136.e4Journal Article, 2020, DOI , TARA - Full Text
  • McEntee, C.P., Moran, H.B.T., Muñoz-Wolf, N., Liddicoat, A.M., Carroll, E.C., Erbo-Wern, J., Coulter, I.S., Andersen, P., Follmann, F. and Lavelle, E.C. (2020). , Type I IFN signalling is required for cationic adjuvant formulation (CAF)01-induced cellular immunity and mucosal priming. , Vaccine, 38, (3), 2020, p635 - 643Journal Article, 2020, DOI
  • Healy, C. and Munoz-Wolf, N. and Strydom, J. and Faherty, L. and Williams, N.C. and Kenny, S. and Donnelly, S.C. and Cloonan, S.M., Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease, Respiratory Research, 22, (1), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
  • Turley, J.L. and Moran, H.B.T. and McEntee, C.P. and O'Grady, K. and Muñoz-Wolf, N. and Jin, L. and Follmann, F. and Andersen, P. and Andersson, M. and Lavelle, E.C., Chitin-derived polymer deacetylation regulates mitochondrial reactive oxygen species dependent cGAS-STING and NLRP3 inflammasome activation, Biomaterials, 275, (120961), 2021Journal Article, 2021
  • Muñoz-Wolf N, Lavelle EC., Promotion of trained innate immunity by nanoparticles., Seminars in immunology, 2021, p101542Journal Article, 2021, DOI
  • Sullivan, G.P. and Davidovich, P. and Muñoz-Wolf, N. and Ward, R.W. and Hernandez Santana, Y.E. and Clancy, D.M. and Gorman, A. and Najda, Z. and Turk, B. and Walsh, P.T. and Lavelle, E.C. and Martin, S.J., Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement, Science immunology, 7, (78), 2022, peade5728Journal Article, 2022
  • Muñoz-Wolf, N. and Ward, R.W. and Hearnden, C.H. and Sharp, F.A. and Geoghegan, J. and O'Grady, K. and McEntee, C.P. and Shanahan, K.A. and Guy, C. and Bowie, A.G. and Campbell, M. and Roces, C.B. and Anderluzzi, G. and Webb, C. and Perrie, Y. and Creagh, E. and Lavelle, E.C., Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles, Cell Reports Medicine, 4, (1), 2023Journal Article, 2023
  • Marqués JM, Rial A, Muñoz N, Pellay FX, Van Maele L, Léger H, Camou T, Sirard JC, Benecke A, Chabalgoity JA., Protection against Streptococcus pneumoniae serotype 1 acute infection shows a signature of Th17- and IFN-"-mediated immunity., Immunobiology, 217, (4), 2012, p420-429Journal Article, 2012
  • Muñoz N, Van Maele L, Marqués JM, Rial A, Sirard JC, Chabalgoity JA., Mucosal administration of flagellin protects mice from Streptococcus pneumoniae lung infection., Infection and immunity, 78, (10), 2010, p4226-4233Journal Article, 2010
  • Porte R, Van Maele L, Muñoz-Wolf N, Foligné B, Dumoutier L, Tabareau J, Cayet D, Gosset P, Jonckheere N, Van Seuningen I, Chabalgoity JA, Simonet M, Lamkanfi M, Renauld JC, Sirard JC, Carnoy C., Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22., Infection and immunity, 85, (2), 2017, pe00806-16Journal Article, 2017
  • Muñoz-Wolf N, Rial A, Fougeron D, Tabareau J, Sirard JC, Chabalgoity JA., Sublingual flagellin protects against acute pneumococcal pneumonia in a TLR5-dependent and NLRC4-independent fashion., Future microbiology, 11, 2016, p1167-1177Journal Article, 2016
  • Porte R, Fougeron D, Muñoz-Wolf N, Tabareau J, Georgel AF, Wallet F, Paget C, Trottein F, Chabalgoity JA, Carnoy C, Sirard JC., A Toll-Like Receptor 5 Agonist Improves the Efficacy of Antibiotics in Treatment of Primary and Influenza Virus-Associated Pneumococcal Mouse Infections., Antimicrobial agents and chemotherapy, 59, (10), 2015, p6064-6072Journal Article, 2015
  • Muñoz-Wolf N, Rial A, Saavedra JM, Chabalgoity JA., Sublingual immunotherapy as an alternative to induce protection against acute respiratory infections., Journal of visualized experiments : JoVE, (90), 2014Journal Article, 2014
  • Jacqueline Maisonnave, Yaneselli, Andrea Filomeno, Gabriel Semiglia, Arce, Kent Erickson, Analia Rial, Natalia Munoz, Maria Moreno, Allogeneic stem cell transplantation for bone regeneration of a nonunion defect in a canine, Veterinary Medicine: Research and Reports, 2013, p39Journal Article, 2013, DOI
  • Ivanov S, Fontaine J, Paget C, Macho Fernandez E, Van Maele L, Renneson J, Maillet I, Muñoz-Wolf N, Rial A, Léger H, Ryffel B, Frisch B, Chabalgoity JA, Sirard JC, Benecke A, Faveeuw C, Trottein F., Key role for respiratory CD103(+) dendritic cells, IFN-", and IL-17 in protection against Streptococcus pneumoniae infection in response to "-galactosylceramide., The Journal of infectious diseases, 206, (5), 2012, p723-734Journal Article, 2012