Professor Ursula Fearon

• Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM, Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity., Journal of immunology (Baltimore, Md. : 1950), 195, (2), 2015, p528-40Journal Article, 2015, DOI
• Gao W, McGarry T, Orr C, McCormick J, Veale DJ, Fearon U, Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors., 2016Journal Article, 2016
• Ademowo OS, Hernandez B, Collins E, Rooney C, Fearon U, van Kuijk AW, Tak PP, Gerlag DM, FitzGerald O, Pennington SR, Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis., 2016Journal Article, 2016
• Verheul MK, Fearon U, Trouw LA, Veale DJ, Biomarkers for rheumatoid and psoriatic arthritis., 2015Journal Article, 2015
• O'Neill L, Rooney P, Molloy D, Connolly M, McCormick J, McCarthy G, Veale DJ, Murphy CC, Fearon U, Molloy E, Regulation of Inflammation and Angiogenesis in Giant Cell Arteritis by Acute-Phase Serum Amyloid A., 2015Journal Article, 2015
• Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G, Wright F, Akil M, Fearon U, Veale D, Ciani B, Wilson AG, C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis., 2015Journal Article, 2015
• Connolly M, Rooney PR, McGarry T, Maratha AX, McCormick J, Miggin SM, Veale DJ, Fearon U, Acute serum amyloid A is an endogenous TLR2 ligand that mediates inflammatory and angiogenic mechanisms., 2015Journal Article, 2015
• Gao W, McCormick J, Connolly M, Balogh E, Veale DJ, Fearon U, Hypoxia and STAT3 signalling interactions regulate pro-inflammatory pathways in rheumatoid arthritis., 2015Journal Article, 2015
• Collins ES, Butt AQ, Gibson DS, Dunn MJ, Fearon U, van Kuijk AW, Gerlag DM, Pontifex E, Veale DJ, Tak PP, FitzGerald O, Pennington SR, A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-" treatment of psoriatic arthritis., 2015Journal Article, 2015
• Veale DJ, Fearon U, What makes psoriatic and rheumatoid arthritis so different?, 2015Journal Article, 2015
• McGarry T, Veale DJ, Gao W, Orr C, Fearon U, Connolly M, Toll-like receptor 2 (TLR2) induces migration and invasive mechanisms in rheumatoid arthritis., 2015Journal Article, 2015
• Biniecka M, Connolly M, Gao W, Ng CT, Balogh E, Gogarty M, Santos L, Murphy E, Brayden D, Veale DJ, Fearon U, Redox-mediated angiogenesis in the hypoxic joint of inflammatory arthritis., 2014Journal Article, 2014
• Fearon U, Veale DJ, Key Challenges in Rheumatic and Musculoskeletal Disease Translational Research., 2014Journal Article, 2014
• Rooney P, Connolly M, Gao W, McCormick J, Biniecka M, Sullivan O, Kirby B, Sweeney C, Molloy E, Markham T, Fearon U, Veale DJ, Notch-1 mediates endothelial cell activation and invasion in psoriasis., 2014Journal Article, 2014
• Strehl C, Fangradt M, Fearon U, Gaber T, Buttgereit F, Veale DJ, Hypoxia: how does the monocyte-macrophage system respond to changes in oxygen availability?, 2014Journal Article, 2014
• McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, Murphy EP, Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity., 2013Journal Article, 2013
• Gao W, Sweeney C, Walsh C, Rooney P, McCormick J, Veale DJ, Fearon U, Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2., 2013Journal Article, 2013
• Mullan RH, Connolly M, Veale DJ, Fearon U, Is the serum amyloid A we use really serum amyloid A? Comment on the article by Connolly et al. Reply., 2013Journal Article, 2013
• Balogh E, Madruga Dias J, Orr C, Mullan R, Harty L, FitzGerald O, Gallagher P, Molloy M, O'Flynn E, Kelly A, Minnock P, O'Neill M, Moore L, Murray M, Fearon U, Veale DJ, Comparison of remission criteria in a tumour necrosis factor inhibitor treated rheumatoid arthritis longitudinal cohort: patient global health is a confounder., 2013Journal Article, 2013
• Gao W, Sweeney C, Connolly M, Kennedy A, Ng CT, McCormick J, Veale DJ, Fearon U, Notch-1 mediates hypoxia-induced angiogenesis in rheumatoid arthritis., 2012Journal Article, 2012
• Marzaioli V, McMorrow JP, Angerer H, Gilmore A, Crean D, Zocco D, Rooney P, Veale D, Fearon U, Gogarty M, McEvoy AN, Stradner MH, Murphy EP, Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes., 2012Journal Article, 2012
• Mix KS, McMahon K, McMorrow JP, Walkenhorst DE, Smyth AM, Petrella BL, Gogarty M, Fearon U, Veale D, Attur MG, Abramson SB, Murphy EP, Orphan nuclear receptor NR4A2 induces synoviocyte proliferation, invasion, and matrix metalloproteinase 13 transcription., 2012Journal Article, 2012
• Yokota K, Miyazaki T, Hemmatazad H, Gay RE, Kolling C, Fearon U, Suzuki H, Mimura T, Gay S, Ospelt C, The pattern-recognition receptor nucleotide-binding oligomerization domain--containing protein 1 promotes production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts., 2012Journal Article, 2012
• Connolly M, Mullan RH, McCormick J, Matthews C, Sullivan O, Kennedy A, FitzGerald O, Poole AR, Bresnihan B, Veale DJ, Fearon U, Acute-phase serum amyloid A regulates tumor necrosis factor " and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy., 2012Journal Article, 2012
• Connolly M, Rooney P, Gao W, Veale D, Fearon U, Acute Serum Amyloid A induces cell migration cytoskeletal rearrangement and Notch signalling in rheumatoid arthritis., 2012Journal Article, 2012
• Moran EM, Connolly M, Gao W, McCormick J, Fearon U, Veale DJ, Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement., 2011Journal Article, 2011
• Connolly M, Veale DJ, Fearon U, Acute serum amyloid A regulates cytoskeletal rearrangement, cell matrix interactions and promotes cell migration in rheumatoid arthritis., 2011Journal Article, 2011
• van de Sande MG, Gerlag DM, Lodde BM, van Baarsen LG, Alivernini S, Codullo V, Felea I, Vieira-Sousa E, Fearon U, Reece R, Montecucco C, Veale DJ, Pitzalis C, Emery P, Klareskog L, McInnes IB, Tak PP, Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials., 2011Journal Article, 2011
• Saber TP, Fearon U, Veale DJ, Is remission a more realistic goal in psoriatic arthritis?, 2011Journal Article, 2011
• Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, Appel H, Fearon U, Veale DJ, IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates., 2011Journal Article, 2011
• Moran EM, Connolly M, Gao W, McCormick J, Fearon U, Veale DJ, Interleukin-17A induction of angiogenesis, cell migration, and cytoskeletal rearrangement., 2011Journal Article, 2011
• Pontifex EK, Gerlag DM, Gogarty M, Vinkenoog M, Gibbs A, Burgman I, Fearon U, Bresnihan B, Tak PP, Gibney RG, Veale DJ, FitzGerald O, Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study., 2011Journal Article, 2011
• Fearon U, Interleukin-27: a master regulator in inflammation., 2011Journal Article, 2011
• van de Sande MG, Gerlag DM, Lodde BM, van Baarsen LG, Alivernini S, Codullo V, Felea I, Vieira-Sousa E, Fearon U, Reece R, Montecucco C, Veale DJ, Pitzalis C, Emery P, Klareskog L, McInnes IB, Tak PP, Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials., 2011Journal Article, 2011
• Saber TP, Fearon U, Veale DJ, Is remission a more realistic goal in psoriatic arthritis?, 2011Journal Article, 2011
• Saber T, Veale DJ, Balogh E, McCormick J, NicAnUltaigh S, Connolly M, Fearon U, Toll-like receptor 2 induced angiogenesis and invasion is mediated through the Tie2 signalling pathway in rheumatoid arthritis., 2011Journal Article, 2011
• Kennedy A, Fearon U, Veale DJ, Godson C, Macrophages in synovial inflammation., 2011Journal Article, 2011
• Moran EM, Heydrich R, Ng CT, Saber TP, McCormick J, Sieper J, Appel H, Fearon U, Veale DJ, IL-17A expression is localised to both mononuclear and polymorphonuclear synovial cell infiltrates., 2011Journal Article, 2011
• Pontifex EK, Gerlag DM, Gogarty M, Vinkenoog M, Gibbs A, Burgman I, Fearon U, Bresnihan B, Tak PP, Gibney RG, Veale DJ, FitzGerald O, Change in CD3 positive T-cell expression in psoriatic arthritis synovium correlates with change in DAS28 and magnetic resonance imaging synovitis scores following initiation of biologic therapy--a single centre, open-label study., 2011Journal Article, 2011
• Connolly M, Marrelli A, Blades M, McCormick J, Maderna P, Godson C, Mullan R, FitzGerald O, Bresnihan B, Pitzalis C, Veale DJ, Fearon U, Acute serum amyloid A induces migration, angiogenesis, and inflammation in synovial cells in vitro and in a human rheumatoid arthritis/SCID mouse chimera model., 2010Journal Article, 2010
• Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U, A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A., 2010Journal Article, 2010
• Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U, Angiogenesis and blood vessel stability in inflammatory arthritis., 2010Journal Article, 2010
• Ng CT, Biniecka M, Kennedy A, McCormick J, Fitzgerald O, Bresnihan B, Buggy D, Taylor CT, O'Sullivan J, Fearon U, Veale DJ, Synovial tissue hypoxia and inflammation in vivo., 2010Journal Article, 2010
• Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U, A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A., 2010Journal Article, 2010
• Kennedy A, Ng CT, Biniecka M, Saber T, Taylor C, O'Sullivan J, Veale DJ, Fearon U, Angiogenesis and blood vessel stability in inflammatory arthritis., 2010Journal Article, 2010
• Saber TP, Ng CT, Renard G, Lynch BM, Pontifex E, Walsh CA, Grier A, Molloy M, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Remission in psoriatic arthritis: is it possible and how can it be predicted?, 2010Journal Article, 2010
• Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Gabalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP, Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers., 2009Journal Article, 2009
• Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U, Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies., 2009Journal Article, 2009
• Oliver KM, Garvey JF, Ng CT, Veale DJ, Fearon U, Cummins EP, Taylor CT, Hypoxia activates NF-kappaB-dependent gene expression through the canonical signaling pathway., 2009Journal Article, 2009
• Bresnihan B, Pontifex E, Thurlings RM, Vinkenoog M, El-Gabalawy H, Fearon U, Fitzgerald O, Gerlag DM, Rooney T, van de Sande MG, Veale D, Vos K, Tak PP, Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers., 2009Journal Article, 2009
• Moran EM, Mullan R, McCormick J, Connolly M, Sullivan O, Fitzgerald O, Bresnihan B, Veale DJ, Fearon U, Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-alpha, Oncostatin M and response to biologic therapies., 2009Journal Article, 2009
• Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin PJ, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F, Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse., 2008Journal Article, 2008
• O'Kane M, Markham T, McEvoy AN, Fearon U, Veale DJ, FitzGerald O, Kirby B, Murphy EP, Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition., 2008Journal Article, 2008
• Burgoyne CH, Field SL, Brown AK, Hensor EM, English A, Bingham SL, Verburg R, Fearon U, Lawson CA, Hamlin PJ, Straszynski L, Veale D, Conaghan P, Hull MA, van Laar JM, Tennant A, Emery P, Isaacs JD, Ponchel F, Abnormal T cell differentiation persists in patients with rheumatoid arthritis in clinical remission and predicts relapse., 2008Journal Article, 2008
• O'Kane M, Markham T, McEvoy AN, Fearon U, Veale DJ, FitzGerald O, Kirby B, Murphy EP, Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition., 2008Journal Article, 2008
• Walsh CA, Fearon U, FitzGerald O, Veale DJ, Bresnihan B, Decreased CD20 expression in rheumatoid arthritis synovium following 8 weeks of rituximab therapy., 2008Journal Article, 2008
• Fearon U, Veale DJ, Angiogenesis in arthritis: methodological and analytical details., 2007Journal Article, 2007
• Greetham D, Ellis CD, Mewar D, Fearon U, an Ultaigh SN, Veale DJ, Guesdon F, Wilson AG, Functional characterization of NF-kappaB inhibitor-like protein 1 (NFkappaBIL1), a candidate susceptibility gene for rheumatoid arthritis., 2007Journal Article, 2007
• Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ, Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy., 2007Journal Article, 2007
• Fearon U, Veale DJ, Angiogenesis in arthritis: methodological and analytical details., 2007Journal Article, 2007
• Veale DJ, Fearon U, Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting., 2006Journal Article, 2006
• Markham T, Mullan R, Golden-Mason L, Rogers S, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy., 2006Journal Article, 2006
• Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'Hara R, FitzGerald O, Veale DJ, Fearon U, Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway., 2006Journal Article, 2006
• Markham T, Mathews C, Rogers S, Mullan R, Bresnihan B, Fitzgerald O, Veale DJ, Fearon U, Downregulation of the inhibitor of apoptosis protein survivin in keratinocytes and endothelial cells in psoriasis skin following infliximab therapy., 2006Journal Article, 2006
• Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ, Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures., 2006Journal Article, 2006
• Veale DJ, Fearon U, Inhibition of angiogenic pathways in rheumatoid arthritis: potential for therapeutic targeting., 2006Journal Article, 2006
• Markham T, Mullan R, Golden-Mason L, Rogers S, Bresnihan B, Fitzgerald O, Fearon U, Veale DJ, Resolution of endothelial activation and down-regulation of Tie2 receptor in psoriatic skin after infliximab therapy., 2006Journal Article, 2006
• Mullan RH, Bresnihan B, Golden-Mason L, Markham T, O'Hara R, FitzGerald O, Veale DJ, Fearon U, Acute-phase serum amyloid A stimulation of angiogenesis, leukocyte recruitment, and matrix degradation in rheumatoid arthritis through an NF-kappaB-dependent signal transduction pathway., 2006Journal Article, 2006
• Leong TT, Fearon U, Veale DJ, Angiogenesis in psoriasis and psoriatic arthritis: clues to disease pathogenesis., 2005Journal Article, 2005
• Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia., 2005Journal Article, 2005
• Mullan R, Lobanok T, Walsh C, King L, FitzGerald O, Bresnihan B, Fearon U, Poole R, Veale D, The value of serum type II collagen epitope measurement in assessing early clinical response to treatment with anti-tumour necrosis factor alpha therapy in rheumatoid arthritis., 2005Journal Article, 2005
• Fearon U, Mullan R, Poole R, Markham T, FitzGerald O, Bresnihan B, Veale D, Oncostatin M in rheumatoid arthritis: a key cytokine acts synergistically with other proinflammatory cytokines to promote human cartilage loss., 2005Journal Article, 2005
• Ponchel F, Verburg RJ, Bingham SJ, Brown AK, Moore J, Protheroe A, Short K, Lawson CA, Morgan AW, Quinn M, Buch M, Field SL, Maltby SL, Masurel A, Douglas SH, Straszynski L, Fearon U, Veale DJ, Patel P, McGonagle D, Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia., 2005Journal Article, 2005
• Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ, Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation., 2003Journal Article, 2003
• Fearon U, Griosios K, Fraser A, Reece R, Emery P, Jones PF, Veale DJ, Angiopoietins, growth factors, and vascular morphology in early arthritis., 2003Journal Article, 2003
• Bingham S, Veale D, Fearon U, Isaacs JD, Morgan G, Emery P, McGonagle D, Reece R, Clague R, Snowden JA, High-dose cyclophosphamide with stem cell rescue for severe rheumatoid arthritis: short-term efficacy correlates with reduction of macroscopic and histologic synovitis., 2002Journal Article, 2002
• Fraser A, Fearon U, Reece R, Emery P, Veale DJ, Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis., 2001Journal Article, 2001
• Fearon U, Veale DJ, Pathways of cell activation in spondyloarthropathies., 2001Journal Article, 2001
• Fearon U, Veale DJ, Pathogenesis of psoriatic arthritis., 2001Journal Article, 2001
• Fearon U, Reece R, Smith J, Emery P, Veale DJ, Synovial cytokine and growth factor regulation of MMPs/TIMPs: implications for erosions and angiogenesis in early rheumatoid and psoriatic arthritis patients., 1999Journal Article, 1999
• Molloy ES, Clarke DM, Fearon UM, Cunningham SK, McKenna TJ, Non-ACTH POMC fragments stimulate aldosterone production by human adrenal cells in vitro., 1998Journal Article, 1998
• Fearon U, Clarke D, McKenna TJ, Cunningham SK, Intra-adrenal factors are not involved in the differential control of cortisol and adrenal androgens in human adrenals., 1998Journal Article, 1998
• McKenna TJ, Fearon U, Clarke D, Cunningham SK, A critical review of the origin and control of adrenal androgens., 1997Journal Article, 1997
• Clarke D, Fearon U, Cunningham SK, McKenna TJ, The steroidogenic effects of beta-endorphin and joining peptide: a potential role in the modulation of adrenal androgen production., 1996Journal Article, 1996
• Biniecka M, Canavan M, McGarry T, Gao W, McCormick J, Cregan S, Gallagher L, Smith T, Phelan JJ, Ryan J, O'Sullivan J, Ng CT, Veale DJ, Fearon U, Dysregulated bioenergetics: a key regulator of joint inflammation., 75, (12), 2016, p2192-2200Journal Article, 2016, DOI
• Conway R, O'Neill L, O'Flynn E, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES, Ustekinumab for the treatment of refractory giant cell arteritis., 2016Journal Article, 2016
• Fearon U, Canavan M, Biniecka M, Veale DJ, Hypoxia, mitochondrial dysfunction and synovial invasiveness in rheumatoid arthritis., 2016Journal Article, 2016
• Sharee A. Basdeo, Deborah Cluxton, Jamal Sulaimani, Barry Moran, Mary Canavan, Carl Orr, Douglas J. Veale, Ursula Fearon and Jean M. Fletcher, Ex-Th17 (Nonclassical Th1) Cells Are Functionally Distinct from Classical Th1 and Th17 Cells and Are Not Constrained by Regulatory T Cells., J immunology, 198 , (2), 2017, p2249 - 2259Journal Article, 2017, DOI
• McGarry T 1 , Biniecka M 1 , Gao W 1 , Cluxton D 2 , Canavan M 1 , Wade S 3 , Wade S 1 , Gallagher L 1 , Orr C 1 , Veale DJ 1 , Fearon U , Resolution of TLR2-induced inflammation through manipulation of metabolic pathways in Rheumatoid Arthritis, Science Reports, 7, (22), 2017, p43165-Journal Article, 2017
• McGarry T, Gao W, Veale DJ, Fearon U, Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis', Annals of Rheumatic Diseases, 8, 2017Journal Article, 2017
• McCarthy C, Orr C, Fee L, Dunlea DM, Hunt DJ, Dunne E, Carroll TP, O'Connell P, McCarthy G, Kenny D, Fearon U, Veale DJ, Reeves EP, McElvaney NG, Genetic variation of the alpha-1-antitrypsin gene is associated with increased autoantibody production in rheumatoid arthritis., 2017Journal Article, 2017
• Mobasheri A, Rayman MP, Gualillo O, Sellam J, van der Kraan P, Fearon U, The role of metabolism in the pathogenesis of osteoarthritis., 2017Journal Article, 2017
• Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A., Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells., Nature medicine, 2017Journal Article, 2017, DOI
• Orr C, Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ., Synovial tissue research: a state-of-the-art review., Nature reviews. Rheumatology, 2017Journal Article, 2017, DOI
• Guo Y, Walsh AM, Fearon U, Smith MD, Wechalekar MD, Yin X, Cole S, Orr C, McGarry T, Canavan M, Kelly S, Lin TA, Liu X, Proudman SM, Veale DJ, Pitzalis C, Nagpal S., CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression., Journal of immunology (Baltimore, Md. : 1950), 198, (11), 2017, p4490-4501Journal Article, 2017, DOI
• Veale DJ, Orr C, Fearon U., Cellular and molecular perspectives in rheumatoid arthritis., Seminars in immunopathology, 39, (4), 2017, p343-354Journal Article, 2017, DOI
• Conway R, Fearon U, Molloy ES., Response to: ustekinumab inhibits Th1 and Th17 polarisation in a giant-cell arteritis patient by Samson et al., Annals of the rheumatic diseases, 2017Journal Article, 2017, DOI
• Orr C, Najm A, Biniecka M, McGarry T, Ng CT, Young F, Fearon U, Veale DJ., Synovial Immunophenotype and Anti-Citrullinated Protein Antibodies in RA patients: Relationship to treatment response and radiological prognosis., Arthritis & rheumatology (Hoboken, N.J.), 2017Journal Article, 2017, DOI
• McGarry T, Biniecka M, Veale DJ, Fearon U, Hypoxia, oxidative stress and inflammation., Free radical biology & medicine, 2018Journal Article, 2018
• Guo Y, Walsh AM, Canavan M, Wechalekar MD, Cole S, Yin X, Scott B, Loza M, Orr C, McGarry T, Bombardieri M, Humby F, Proudman SM, Pitzalis C, Smith MD, Friedman JR, Anderson I, Madakamutil L, Veale, Fearon U, Nagpal S, Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression., PloS one, 2018Journal Article, 2018
• Najm A, Orr C, Gallagher L, Biniecka M, Gaigneux E, Le Goff B, Fearon U, Veale DJ, Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology., RMD open, 2018Journal Article, 2018
• McGarry T, Gao W, Veale DJ, Fearon U., Response to: 'Regulatory role of the JAK STAT kinase signalling system on the IL-23/IL-17 cytokine axis in psoriatic arthritis' by Raychaudhuri et al., Annals of the rheumatic diseases, 76, (10), 2017, pe37Journal Article, 2017, DOI
• Cole S, Walsh A, Yin X, Wechalekar MD, Smith MD, Proudman SM, Veale DJ, Fearon U, Pitzalis C, Humby F, Bombardieri M, Axel A, Adams H, Chiu C, Guo Y, Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus., Arthritis research & therapy, 2018Journal Article, 2018
• O'Rourke M, Fearon U, Sweeney CM, Basdeo SA, Fletcher JM, Murphy CC, Canavan M, The pathogenic role of dendritic cells in non-infectious anterior uveitis., Experimental eye research, 2018, p121 - 128Journal Article, 2018, DOI
• Conway R, O'Neill L, Gallagher P, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Molloy ES, Ustekinumab for refractory giant cell arteritis: A prospective 52-week trial., Seminars in arthritis and rheumatism, 2018Journal Article, 2018
• McGarry T, Orr C, Wade S, Biniecka M, Wade S, Gallagher L, Low C, Veale DJ, Fearon U, JAK-STAT blockade alters synovial bioenergetics, mitochondrial function and pro-inflammatory mediators in Rheumatoid arthritis., Arthritis & rheumatology (Hoboken, N.J.), 2018Journal Article, 2018
• Balogh E, Veale DJ, McGarry T, Orr C, Szekanecz Z, Ng CT, Fearon U, Biniecka M, Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis., Arthritis Res Ther, 1, (1), 2018, p95-Journal Article, 2018
• Veale DJ, Fearon U., The pathogenesis of psoriatic arthritis., Lancet, 391, ((10136)), 2018, p:2273 - -2284Journal Article, 2018
• Conway R, O'Neill L, McCarthy GM, Murphy CC, Fabre A, Kennedy S, Veale DJ, Wade SM, Fearon U, Molloy ES, Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis., Ann Rheum Dis. , 77, (12), 2018, p1815 - 1824Journal Article, 2018, DOI
• Orr CK, Najm A, Young F, McGarry T, Biniecka M, Fearon U, Veale DJ., The Utility and Limitations of CRP, ESR and DAS28-CRP in Appraising Disease Activity in Rheumatoid Arthritis., Front Med , 3, (5), 2018, p185-Journal Article, 2018
• Wade SM, Trenkmann M, McGarry T, Canavan M, Marzaioli V, Wade SC, Veale DJ, Fearon U, Altered expression of microRNA-23a in psoriatic arthritis modulates synovial fibroblast pro-inflammatory mechanisms via phosphodiesterase 4B., J Autoimmunity, S0896-84, (S0896-84), 2018Journal Article, 2018
• O'Rourke M, Trenkmann M, Connolly M, Fearon U, Murphy CC, Novel gene targets for miRNA146a and miRNA155 in anterior uveitis., Br J Ophthalmol., Oct 8. pii: bj, (Oct 8. pii: bj), 2018, pepub ahead-Journal Article, 2018
• Canavan M, Walsh AM, Bhargava V, Wade SM, McGarry T, Marzaioli V, Moran B, Biniecka M, Convery H, Wade S, Orr C, Mullan R, Fletcher JM, Nagpal S, Veale DJ, Fearon U, Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis., JCI Insight, 3, (23), 2018, p95228-Journal Article, 2018, DOI , TARA - Full Text
• Wade SM, Canavan M, McGarry T, Low C, Wade SC, Mullan RH, Veale DJ, Fearon U, Association of synovial tissue polyfunctional T-cells with DAPSA in psoriatic arthritis., (Jan 10th), 2019Journal Article, 2019
• Conway R, O'Neill L, McCarthy GM, Murphy CC, Veale DJ, Fearon U, Killeen RP, Heffernan EJ, Molloy ES, Performance characteristics and predictors of temporal artery ultrasound for the diagnosis of giant cell arteritis in routine clinical practice in a prospective cohort., Clin Exp Rheumatol., Jan4th, 2019, pEpub-Journal Article, 2019
• McGarry T, Fearon U, Cell metabolism as a potentially targetable pathway in RA. , Nat Rev Rheumatol. , Dec 18th, 2018Journal Article, 2018
• Najm A, Le Goff B, Orr C, Thurlings R, Cañete JD, Humby F, Alivernini S, Manzo A, Just SA, Romão VC, Krenn V, Müller-Ladner U, Addimanda O, Tas SW, Stoenoiu M, Meric de Bellefon L, Durez P, Strand V, Wechalekar MD, Fonseca JE, Lauwerys B, Fearon U, Veale DJ; EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group., Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups., Arthritis Res Ther, 1, 2018, p265-Journal Article, 2018
• Balogh E, Pusztai A, Hamar A, Végh E, Szamosi S, Kerekes G, McCormick J, Biniecka M, Szántó S, Szűcs G, Nagy Z, Fearon U, Veale DJ, Szekanecz Z, Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis., Clinical Immunology, 18, 2018, p30721-Journal Article, 2018
• Ui Mhaonaigh, A. and Coughlan, A.M. and Dwivedi, A. and Hartnett, J. and Cabral, J. and Moran, B. and Brennan, K. and Doyle, S.L. and Hughes, K. and Lucey, R. and Floudas, A. and Fearon, U. and McGrath, S. and Cormican, S. and De Bhailis, A. and Molloy, E.J. and Brady, G. and Little, M.A., Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies, Frontiers in Immunology, 10, (2603), 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Balogh E, Pusztai A, Hamar A, Végh E, Szamosi S, Kerekes G, McCormick J, Biniecka M, Szántó S, Szűcs G, Nagy Z, Fearon U, Veale DJ, Szekanecz Z, Autoimmune and angiogenic biomarkers in autoimmune atherosclerosis., Clin Immunol. , Feb 199:, 2019, p47 - 51Journal Article, 2019
• Balogh E, Biniecka M, Fearon U, Veale DJ, Szekanecz Z, Angiogenesis in Inflammatory Arthritis., Isr Med Assoc J. , May;5(21):, 2019, p345 - 353Journal Article, 2019
• O'Neill L, McCormick J, Gao W, Veale DJ, McCarthy GM, Murphy CC, Fearon U, Molloy ES, Interleukin-6 does not upregulate pro-inflammatory cytokine expression in an ex vivo model of giant cell arteritis., Rheumatol Adv Pract. , May 6;3(1):rkz0, 2019, p3(1):rkz0-Journal Article, 2019
• Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U., Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis., EBioMedicine. , Sep;47:, 2019, p402 - 413Journal Article, 2019
• Hanlon MM, Rakovich T, Cunningham CC, Ansboro S, Veale DJ,McGarry T, Fearon U, , STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function., Front Immunol. 2019 , Aug 28;10:, 2019, p2056-Journal Article, 2019
• Dorris ER, Linehan E, Trenkmann M, Veale DJ, Fearon U, Wilson AG., Association of the Rheumatoid Arthritis Severity Variant rs26232 with the Invasive Activity of Synovial Fibroblasts., Cells, Oct 22;8(10). pii: E, 2019Journal Article, 2019
• Foley C, Floudas A, Canavan M, Biniecka M, MacDermott EJ, Veale DJ, Mullan RH, Killeen OG, Fearon U., Increased T cell plasticity with dysregulation of T follicular helper, T peripheral helper and T regulatory cell responses in children with JIA and Down syndrome-associated arthritis., Arthritis Rheumatol. 2019 Oct 27., Oct 27th, 2019Journal Article, 2019
• Gallagher L, Cregan S, Biniecka M, Cunningham C, Veale DJ, Kane DJ, Fearon U, Mullan RH, Insulin Resistant Pathways are associated with Disease Activity in Rheumatoid Arthritis and are Subject to Disease Modification through Metabolic Reprogramming; A Potential Novel Therapeutic Approach., Arthritis Rheumatol. , DEc16, 2019Journal Article, 2019
• Fromm S, Cunningham CC, Dunne MR, Veale DJ,Wade SM, Fearon U., Enhanced angiogenic function in response to fibroblasts from psoriatic arthritis synovium compared to rheumatoid arthritis., Arthritis Res Ther., Dec 21;21(1):, 2019, p2 - 6Journal Article, 2019
• Veale DJ, Fearon U, Next-generation analysis of synovial tissue architecture., Nat Rev Rheumatol., 2020 Feb;16(2):, 2020, p67 - 69Journal Article, 2020
• Enrichment of polyfunctional T cells in PsA synovial tissue, Canavan M, Wade SM, Veale DJ, Fearon U., Ann Rheum Dis. , Jan 8th, 2020Journal Article, 2020
• Floudas A, Neto N, Marzaioli V, Murray K, Moran B, Monaghan MG, Low C, Mullan RH, Rao N, Krishna V, Nagpal S, Veale DJ, Fearon U., Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint., JCI insight, 5, (21), 2020Journal Article, 2020, DOI
• Clare Cunningham1,2, Sarah Wade1,2, Carl Orr2, Achilleas Floudas1,2, Trudy McGarry1, Siobhan Wade, AChilleas Floudas, Sian Cregan, Ursula Fearon, Douglas J Veale., Serum miRNAs signature in Rheumatoid Arthritis and 'at risk individuals', Frontiers in Immunology, Mar, fimmu.2021.633, 2021Journal Article, 2021
• Murray K, Floudas A, Murray C, Fabre A, Crown J, Fearon U, Veale D, First use of tofacitinib to treat an immune checkpoint inhibitor-induced arthritis., BMJ, Feb 4;14(2):e238851., 2021Journal Article, 2021
• McGarry T, Hanlon MM, Marzaioli V, Cunningham CC, Krishna V, Murray K, Hurson C, Gallagher P, Nagpal S, Veale DJ, Fearon U, Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease., Clin Transl Immunology, Feb 19;10(1):e1237. , 2021Journal Article, 2021
• Murray K, Turk M, Alammari Y, Young F, Gallagher P, Saber T, Fearon U, Veale DJ., Long-term remission and biologic persistence rates: 12-year real-world data., Arthritis Res Ther, Jan 13;23(1):25., 2021Journal Article, 2021
• Murray K, Quinn S, Turk M, O'Rourke A, Molloy E, O'Neill L, Mongey AB, Fearon U, Veale DJ., COVID-19 and rheumatic musculoskeletal disease patients: infection rates, attitudes and medication adherence in an Irish population., Rheumatology, Feb 1;60(2):902-906, 2021Journal Article, 2021
• Petrasca A, Phelan JJ, Ansboro S, Veale DJ, Fearon U, Fletcher JM., Share Targeting bioenergetics prevents CD4 T cell-mediated activation of synovial fibroblasts in rheumatoid arthritis., Rheumatology, Oct 1;59(10):2816-28, 2020Journal Article, 2020
• Wade SM, McGarry T, Wade SC, Fearon U, Veale DJ, Share Serum MicroRNA Signature as a Diagnostic and Therapeutic Marker in Patients with Psoriatic Arthritis, J Rheumatol, Dec 1;47(12):1760-17, 2020Journal Article, 2020
• Canavan M, Marzaioli V, McGarry T, Bhargava V, Nagpal S, Veale DJ, Fearon U., Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells., Clin Exp Immunol, Nov;202(2):226-238., 2020Journal Article, 2020
• Najm A, Masson FM, Preuss P, Georges S, Ory B, Quillard T, Sood S, Goodyear CS, Veale DJ, Fearon U, Le Goff B, Blanchard F, 8 Cite Share MicroRNA-17-5p Reduces Inflammation and Bone Erosions in Mice With Collagen-Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes., Arthritis Rheumatol., Dec;72(12):2030-2039, 2020Journal Article, 2020
• Marzaioli V, Canavan M, Floudas A, Wade SC, Low C, Veale DJ, Fearon U., Monocyte-Derived Dendritic Cell Differentiation in Inflammatory Arthritis Is Regulated by the JAK/STAT Axis via NADPH Oxidase Regulation., Front Immunol, Jul 7;11:1406., 2020Journal Article, 2020
• Angiogenesis in, Kelleys 11th edition, Rheumatology , Kelleys, 2020, [129. Ursula Fearon, Douglas Veale and Zoltan Szekanecz ]Book Chapter, 2020
• Achilleas Floudas, Mary Canavan, Trudy McGarry, Ronan Mullan, Sunil Nagpal, Doug Veale, Ursula Fearon, ACPA status correlates with differential immune profile in patients with Rheumatoid Arthritis, Cells, In press, 2021Journal Article, 2021
• Floudas A, Canavan M, McGarry T, Mullan R, Nagpal S, Veale DJ, Fearon U., ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis, Cells, ;10(3):, (64), 2021, pdoi: 10.33-Journal Article, 2021
• Turk M, Murray K, Alammari Y, Gorman A, Young F, Gallagher P, Saber T, Freeman L, Maguire S, O'Shea F, Fearon U, Veale D, The effects of alcohol consumption and its associations with disease activity among 979 patients with inflammatory arthritis. , RMD Open, Apr;7(2):e00151, 2021Journal Article, 2021, URL
• O'Brien A, Hanlon MM, Marzaioli V, Wade SC, Flynn K, Fearon U, Veale DJ., Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function., Frontiers in immunology, 12, 2021, p672461Journal Article, 2021, DOI
• Floudas A, Neto N, Orr C, Canavan M, Gallagher P, Hurson C, Monaghan MG, Nagpar S, Mullan RH, Veale DJ, Fearon U., Loss of balance between protective and pro-inflammatory synovial tissue T-cell polyfunctionality predates clinical onset of rheumatoid arthritis., Annals of the rheumatic diseases, 2021Journal Article, 2021, DOI
• Marzaioli V, Canavan M, Floudas A, Flynn K, Mullan R, Veale DJ, Fearon U., CD209/CD14+ Dendritic Cells Characterization in Rheumatoid and Psoriatic Arthritis Patients: Activation, Synovial Infiltration, and Therapeutic Targeting., Frontiers in Immunology, 2022Journal Article, 2022
• Igea A, Carvalheiro T, Malvar-Fernández B, Martinez-Ramos S, Rafael-Vidal C, Niemantsverdriet E, Varadé J, Fernández-Carrera A, Jimenez N, McGarry T, Rodriguez-Trillo A, Veale D, Fearon U, Conde C, Pego-Reigosa JM, González-Fernández Á, Reedquist KA, Radstake TRDJ, van der Helm-Van Mil AH, García S., Semaphorin3B plays a central role in serum-induced arthritis model and is reduced in patients with rheumatoid arthritis., Arthritis & rheumatology (Hoboken, N.J.), 2022Journal Article, 2022, DOI
• Canavan M, Marzaioli V, Bhargava V, Nagpal S, Gallagher P, Hurson C, Mullan R, Veale DJ, Fearon U., Functionally Mature CD1c⁺ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium., Frontiers in immunology, 12, 2021, p745226Journal Article, 2021, DOI
• Hanlon MM, Canavan M, Barker BE, Fearon U., Metabolites as drivers and targets in Rheumatoid Arthritis., Clinical and experimental immunology, 2021Journal Article, 2021, DOI
• Floudas A, Gorman A, Neto N, Monaghan MG, Elliott Z, Fearon U, Marzaioli V., Inside the Joint of Inflammatory Arthritis Patients: Handling and Processing of Synovial Tissue Biopsies for High Throughput Analysis., Frontiers in medicine, 9, 2022, p830998Journal Article, 2022, DOI
• Angiogenesis in, Textbook of Rheumatology, Elsevier, 1981, pp445 - 455, [Ursula Fearon, Zoltan Szekanecz, Douglas Veale]Book Chapter, 1981
• Angiogenesis in, Textbook of Rheumatology, 1981, pp445 - 555, [Ursula Fearon, Zoltan Szekanecz, Douglas Veale]Book Chapter, 1981
• Fearon U, Hanlon MM, Floudas A, Veale DJ., Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications. , Nature reviews. Rheumatology, 2022Journal Article, 2022, DOI
• Clíodhna McHugh , Karen Hind , Aine Kelly, Ursula Fearon, Meagan Wasfy,Achilleas Floudas, Zsuzsanna Barad, Kathryn Dane ,Gareth Farrell, Fiona Wilson, Cardiovascular risk and systemic inflammation in male professional rugby: a cross-sectional study, BMJ Open Sports and Exercise Medicine, 2023Journal Article, 2023, URL , TARA - Full Text
• Nanda KS, Brady JJ, Murray BF, Sullivan O, Fearon U, McKenna MJ, Hegarty JE, O'Farrelly C, Ryan EJ, Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection., Cytokine, 60, (2), 2012, p328-33Journal Article, 2012, DOI

• Rheumatoid Arthritis in, editor(s)John H Stone , Current Diagnosis and Treatment, McGraw Hill, 2021, pp149 - 166, [Douglas Veale, Ursula Fearon]Book Chapter

• Title

  To identify the underlying mechanisms involved in driving the distinct pathogenesis observed in PsA and RA, and to define how these impacts on therapeutic response
  Summary
  Funding Agency

  HRCI HRB
• Title

  - Identification of molecular signatures of Synovial Inflammation
  Summary
  Funding Agency

  Janssen Newman Fellowship
  Date From

  2020

Immunity and Infection (including Rheumatology & Inflammatory disease), Biochemistry, Molecular & Cellular Biology,