Dr. Suzanne Cloonan

• Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505Journal Article, 2015, DOI
• Zhang, William Z and Cloonan, Suzanne M, To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model, American journal of respiratory cell and molecular biology, 62, (5), 2020, p541â€"542Journal Article, 2020, DOI , URL , TARA - Full Text
• Bessman, Nicholas J and Mathieu, Jacques R R and Renassia, Cyril and Zhou, Lei and Fung, Thomas C and Fernandez, Keith C and Austin, Christine and Moeller, Jesper B and Zumerle, Sara and Louis, Sabine and Vaulont, Sophie and Ajami, Nadim J and Sokol, Harry and Putzel, Gregory G and Arvedson, Tara and Sockolow, Robbyn E and Lakhal-Littleton, Samira and Cloonan, Suzanne M and Arora, Manish and Peyssonnaux, Carole and Sonnenberg, Gregory F, Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing, Science (New York, N.Y.), 368, (6487), 2020, p186â€"189Journal Article, 2020, DOI , URL , TARA - Full Text
• O'Beirne, Sarah L and Kikkers, Sarah Ann and Oromendia, Clara and Salit, Jacqueline and Rostmai, Mahboubeh R and Ballman, Karla V and Kaner, Robert J and Crystal, Ronald G and Cloonan, Suzanne M, Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 201, (6), 2020, p735â€"739Journal Article, 2020, DOI , URL , TARA - Full Text
• Zhang, William Z and Rice, Michelle C and Hoffman, Katherine L and Oromendia, Clara and Barjaktarevic, Igor Z and Wells, J Michael and Hastie, Annette T and Labaki, Wassim W and Cooper, Christopher B and Comellas, Alejandro P and Criner, Gerard J and Krishnan, Jerry A and Paine, Robert and Hansel, Nadia N and Bowler, Russell P and Barr, R Graham and Peters, Stephen P and Woodruff, Prescott G and Curtis, Jeffrey L and Han, Meilan K and Ballman, Karla V and Martinez, Fernando J and Choi, Augustine Mk and Nakahira, Kiichi and Cloonan, Suzanne M and Choi, Mary E and {SPIROMICS Investigators, Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort, JCI insight, 5, (3), 2020Journal Article, 2020, DOI , URL , TARA - Full Text
• Aghapour, Mahyar and Remels, Alexander H V and Pouwels, Simon D and Bruder, Dunja and Hiemstra, Pieter S and Cloonan, Suzanne M and Heijink, Irene H, Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease, American journal of physiology. Lung cellular and molecular physiology, 318, (1), 2020, pL149â€"L164Journal Article, 2020, DOI , URL
• Chung, Kuei-Pin and Hsu, Chia-Lang and Fan, Li-Chao and Huang, Ziling and Bhatia, Divya and Chen, Yi-Jung and Hisata, Shu and Cho, Soo Jung and Nakahira, Kiichi and Imamura, Mitsuru and Choi, Mary E and Yu, Chong-Jen and Cloonan, Suzanne M and Choi, Augustine M K, Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis, Nature communications, 10, (1), 2019, p3390Journal Article, 2019, DOI , URL , TARA - Full Text
• Najafinobar, Neda and Venkatesan, Shalini and von Sydow, Lena and Klarqvist, Magnus and Olsson, Henric and Zhou, Xiao-Hong and Cloonan, Suzanne M and Malmberg, Per, ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients, Scientific reports, 9, (1), 2019, p10060Journal Article, 2019, DOI , URL , TARA - Full Text
• Plataki, Maria and Fan, LiChao and Sanchez, Elizabeth and Huang, Ziling and Torres, Lisa K and Imamura, Mitsuru and Zhu, Yizhang and Cohen, David E and Cloonan, Suzanne M and Choi, Augustine Mk, Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity, JCI insight, 5, 2019Journal Article, 2019, DOI , URL , TARA - Full Text
• Faner, Rosa and Morrow, Jarrett D and Casas-Recasens, Sandra and Cloonan, Suzanne M and Noell, Guillaume and López-Giraldo, Alejandra and Tal-Singer, Ruth and Miller, Bruce E and Silverman, Edwin K and Agustí, Alvar and Hersh, Craig P, Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis, Respiratory research, 20, (1), 2019, p5Journal Article, 2019, DOI , URL
• Ward, Diane M and Cloonan, Suzanne M, Mitochondrial Iron in Human Health and Disease, Annual review of physiology, 81, 2019, p453â€"482Journal Article, 2019, DOI , URL , TARA - Full Text
• Pabón, Maria A and Patino, Edwin and Bhatia, Divya and Rojas-Quintero, Joselyn and Ma, Kevin C and Finkelsztein, Eli J and Osorio, Juan C and Malick, Faryal and Polverino, Francesca and Owen, Caroline A and Ryter, Stefan W and Choi, Augustine Mk and Cloonan, Suzanne M and Choi, Mary E, Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease, JCI insight, 3, (18), 2018Journal Article, 2018, DOI , URL
• Zhang, William Z and Butler, James J and Cloonan, Suzanne M, Smoking-induced iron dysregulation in the lung, Free radical biology & medicine, 133, 2019, p238â€"247Journal Article, 2019, DOI , URL
• Ma, Kevin C and Schenck, Edward J and Siempos, Ilias I and Cloonan, Suzanne M and Finkelsztein, Eli J and Pabon, Maria A and Oromendia, Clara and Ballman, Karla V and Baron, Rebecca M and Fredenburgh, Laura E and Higuera, Angelica and Lee, Jin Young and Chung, Chi Ryang and Jeon, Kyeongman and Yang, Jeong Hoon and Howrylak, Judie A and Huh, Jin-Won and Suh, Gee Young and Choi, Augustine Mk, Circulating RIPK3 levels are associated with mortality and organ failure during critical illness, JCI insight, 3, (13), 2018Journal Article, 2018, DOI , URL
• Racanelli, Alexandra C and Kikkers, Sarah Ann and Choi, Augustine M K and Cloonan, Suzanne M, Autophagy and inflammation in chronic respiratory disease, Autophagy, 14, (2), 2018, p221â€"232Journal Article, 2018, DOI , URL
• Cloonan, Suzanne M, Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis, American journal of respiratory and critical care medicine, 196, (12), 2017, p1502â€"1504Journal Article, 2017, DOI , URL
• Cloonan, Suzanne M and Mumby, Sharon and Adcock, Ian M and Choi, Augustine M K and Chung, Kian Fan and Quinlan, Gregory J, The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease, American journal of respiratory and critical care medicine, 196, (9), 2017, p1103â€"1112Journal Article, 2017, DOI , URL
• Morrow, Jarrett D and Zhou, Xiaobo and Lao, Taotao and Jiang, Zhiqiang and DeMeo, Dawn L and Cho, Michael H and Qiu, Weiliang and Cloonan, Suzanne and Pinto-Plata, Victor and Celli, Bartholome and Marchetti, Nathaniel and Criner, Gerard J and Bueno, Raphael and Washko, George R and Glass, Kimberly and Quackenbush, John and Choi, Augustine M K and Silverman, Edwin K and Hersh, Craig P, Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue, Scientific reports, 7, 2017, p44232Journal Article, 2017, DOI , URL
• Mizumura, Kenji and Cloonan, Suzanne and Choi, Mary E and Hashimoto, Shu and Nakahira, Kiichi and Ryter, Stefan W and Choi, Augustine M K, Autophagy: Friend or Foe in Lung Disease?, Annals of the American Thoracic Society, 13 Suppl 1, 2016, pS40â€"7Journal Article, 2016, DOI , URL
• Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria in lung disease, The Journal of clinical investigation, 126, (3), 2016, p809â€"820Journal Article, 2016, DOI , URL
• Cloonan, Suzanne M and Glass, Kimberly and Laucho-Contreras, Maria E and Bhashyam, Abhiram R and Cervo, Morgan and Pabón, Maria A and Konrad, Csaba and Polverino, Francesca and Siempos, Ilias I and Perez, Elizabeth and Mizumura, Kenji and Ghosh, Manik C and Parameswaran, Harikrishnan and Williams, Niamh C and Rooney, Kristen T and Chen, Zhi-Hua and Goldklang, Monica P and Yuan, Guo-Cheng and Moore, Stephen C and Demeo, Dawn L and Rouault, Tracey A and D'Armiento, Jeanine M and Schon, Eric A and Manfredi, Giovanni and Quackenbush, John and Mahmood, Ashfaq and Silverman, Edwin K and Owen, Caroline A and Choi, Augustine M K, Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice, Nature medicine, 22, (2), 2016, p163â€"174Journal Article, 2016, DOI , URL
• Mizumura, Kenji and Cloonan, Suzanne M and Nakahira, Kiichi and Bhashyam, Abhiram R and Cervo, Morgan and Kitada, Tohru and Glass, Kimberly and Owen, Caroline A and Mahmood, Ashfaq and Washko, George R and Hashimoto, Shu and Ryter, Stefan W and Choi, Augustine M K, Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD, The Journal of clinical investigation, 124, (9), 2014, p3987â€"4003Journal Article, 2014, DOI , URL
• Cloonan, Suzanne M and Lam, Hilaire C and Ryter, Stefan W and Choi, Augustine M, "Ciliophagy": The consumption of cilia components by autophagy, Autophagy, 10, (3), 2014, p532â€"534Journal Article, 2014, DOI , URL
• Lam, Hilaire C and Cloonan, Suzanne M and Bhashyam, Abhiram R and Haspel, Jeffery A and Singh, Anju and Sathirapongsasuti, J Fah and Cervo, Morgan and Yao, Hongwei and Chung, Anna L and Mizumura, Kenji and An, Chang Hyeok and Shan, Bin and Franks, Jonathan M and Haley, Kathleen J and Owen, Caroline A and Tesfaigzi, Yohannes and Washko, George R and Quackenbush, John and Silverman, Edwin K and Rahman, Irfan and Kim, Hong Pyo and Mahmood, Ashfaq and Biswal, Shyam S and Ryter, Stefan W and Choi, Augustine M K, Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction, The Journal of clinical investigation, 123, (12), 2013, p5212â€"5230Journal Article, 2013, DOI , URL
• Nakahira, Kiichi and Cloonan, Suzanne M and Mizumura, Kenji and Choi, Augustine M K and Ryter, Stefan W, Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease, Antioxidants & redox signaling, 20, (3), 2014, p474â€"494Journal Article, 2014, DOI , URL
• Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â€"338Journal Article, 2013, DOI , URL
• Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: sensors and mediators of innate immune receptor signaling, Current opinion in microbiology, 16, (3), 2013, p327â€"338Journal Article, 2013, DOI , URL
• Ryter, Stefan W and Cloonan, Suzanne M and Choi, Augustine M K, Autophagy: a critical regulator of cellular metabolism and homeostasis, Molecules and cells, 36, (1), 2013, p7â€"16Journal Article, 2013, DOI , URL
• Mizumura, Kenji and Cloonan, Suzanne M and Haspel, Jeffrey A and Choi, Augustine M K, The emerging importance of autophagy in pulmonary diseases, Chest, 142, (5), 2012, p1289â€"1299Journal Article, 2012, DOI , URL
• Constantin, Myrna and Choi, Alexander J S and Cloonan, Suzanne M and Ryter, Stefan W, Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease, International journal of hypertension, 2012, 2012, p859235Journal Article, 2012, DOI , URL
• Cloonan, Suzanne M and Choi, Augustine M K, Mitochondria: commanders of innate immunity and disease?, Current opinion in immunology, 24, (1), 2012, p32â€"40Journal Article, 2012, DOI , URL
• Zhang William Z, Oromendia Clar, Kikkers Sarah An, Butler James J, O†Beirne Sara, Kim Kihwa, O†Neal Wanda K, Freeman Christine M, Christenson Stephanie A, Peters Stephen P, Wells J. Michae, Doerschuk Clair, Putcha Nirupam, Barjaktarevic Igo, Woodruff Prescott G, Cooper Christopher B, Bowler Russell P, Comellas Alejandro P, Criner Gerard J, Paine Rober, Hansel Nadia N, Han Meilan K, Crystal Ronald G, Kaner Robert J, Ballman Karla V, Curtis Jeffrey L, Martinez Fernando J, Cloonan Suzanne M, Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS, Scientific Reports, 10, (1), 2020, p10562-Journal Article, 2020, DOI , URL , TARA - Full Text
• Healy, C. and Munoz-Wolf, N. and Strydom, J. and Faherty, L. and Williams, N.C. and Kenny, S. and Donnelly, S.C. and Cloonan, S.M., Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease, Respiratory Research, 22, (1), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Zhang, W.Z. and Hoffman, K.L. and Schiffer, K.T. and Oromendia, C. and Rice, M.C. and Barjaktarevic, I. and Peters, S.P. and Putcha, N. and Bowler, R.P. and Wells, J.M. and Couper, D.J. and Labaki, W.W. and Curtis, J.L. and Han, M.K. and Paine, R. and Woodruff, P.G. and Criner, G.J. and Hansel, N.N. and Diaz, I. and Ballman, K.V. and Nakahira, K. and Choi, M.E. and Martinez, F.J. and Choi, A.M.K. and Cloonan, S.M., Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort, Respiratory Research, 22, (1), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Robinson, E.K. and Jagannatha, P. and Covarrubias, S. and Cattle, M. and Smaliy, V. and Safavi, R. and Shapleigh, B. and Abu-Shumays, R. and Jain, M. and Cloonan, S.M. and Akeson, M. and Brooks, A.N. and Carpenter, S., Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of aim2, eLife, 10, (e69431), 2021Journal Article, 2021, DOI , URL , TARA - Full Text
• Lam, H.C. and Cloonan, S.M. and Bhashyam, A.R. and Haspel, J.A. and Singh, A. and Fah Sathirapongsasuti, J. and Cervo, M. and Yao, H. and Chung, A.L. and Mizumura, K. and An, C.H. and Shan, B. and Franks, J.M. and Haley, K.J. and Owen, C.A. and Tesfaigzi, Y. and Washko, G.R. and Quackenbush, J. and Silverman, E.K. and Rahman, I. and Kim, H.P. and Mahmood, A. and Biswal, S.S. and Ryter, S.W. and Choi, A.M.K., Erratum: Histone deacetylase 6â€"mediated selective autophagy regulates COPD-associated cilia dysfunction (Journal of Clinical Investigation (2013) 123:12 (5212-5230) DOI: 10.1172/JCI69636), Journal of Clinical Investigation, 130, (11), 2020, p6189Journal Article, 2020, DOI , URL
• Perez, E. and Baker, J.R. and Giandomenico, S.D. and Kermani, P. and Parker, J. and Kim, K. and Yang, J. and Barnes, P.J. and Vaulont, S. and Scandura, J.M. and Donnelly, L.E. and Stout-Delgado, H. and Cloonan, S.M., Hepcidin is essential for alveolar macrophage function and is disrupted by smoke in a murine chronic obstructive pulmonary disease model, Journal of Immunology, 205, (9), 2020, p2489-2498Journal Article, 2020, DOI , URL
• Zhang, W.Z. and Cloonan, S.M., To †Fe†ed or not to †Fe†ed: Iron depletion exacerbates emphysema development in murine smoke model, American Journal of Respiratory Cell and Molecular Biology, 62, (5), 2020, p541-542Journal Article, 2020, DOI , URL
• Cloonan, S.M. and Kim, K. and Esteves, P. and Trian, T. and Barnes, P.J., Mitochondrial dysfunction in lung ageing and disease, European Respiratory Review, 29, (157), 2020Journal Article, 2020, DOI , URL
• Faner, R. and Morrow, J.D. and Casas-Recasens, S. and Cloonan, S.M. and Noell, G. and López-Giraldo, A. and Tal-Singer, R. and Miller, B.E. and Silverman, E.K. and Agustí, A. and Hersh, C.P., Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology, Respiratory Research, 20, (1), 2019Journal Article, 2019, DOI , URL
• Burstein, S.R. and Valsecchi, F. and Kawamata, H. and Bourens, M. and Zeng, R. and Zuberi, A. and Milner, T.A. and Cloonan, S.M. and Lutz, C. and Barrientos, A. and Manfredi, G., In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions, Human Molecular Genetics, 27, (1), 2018, p160-177Journal Article, 2018, DOI , URL
• Cloonan, S.M. and Mumby, S. and Adcock, I.M. and Choi, A.M.K. and Chung, K.F. and Quinlan, G.J., The iron-y of iron overload and iron deficiency in chronic obstructive pulmonary disease, American Journal of Respiratory and Critical Care Medicine, 196, (9), 2017, p1103-1112Journal Article, 2017, DOI , URL
• Cloonan, S.M. and Lam, H.C. and Ryter, S.W. and Choi, A.M., Ciliophagy : The consumption of cilia components by autophagy, Autophagy, 10, (3), 2014, p532-534Journal Article, 2014, DOI , URL
• Sayles, N.M. and Southwell, N. and McAvoy, K. and Kim, K. and Pesini, A. and Anderson, C.J. and Quinzii, C. and Cloonan, S. and Kawamata, H. and Manfredi, G., Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy, Cell Reports, 38, (10), 2022Journal Article, 2022, DOI , URL
• Williams, N.C. and Ryan, D.G. and Costa, A.S.H. and Mills, E.L. and Jedrychowski, M.P. and Cloonan, S.M. and Frezza, C. and O'Neill, L.A., Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages, Journal of Biological Chemistry, 298, (2), 2022Journal Article, 2022, DOI , URL , TARA - Full Text
• Ramchandani, D. and Berisa, M. and Tavarez, D.A. and Li, Z. and Miele, M. and Bai, Y. and Lee, S.B. and Ban, Y. and Dephoure, N. and Hendrickson, R.C. and Cloonan, S.M. and Gao, D. and Cross, J.R. and Vahdat, L.T. and Mittal, V., Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis, Nature Communications, 12, (1), 2021Journal Article, 2021, DOI
• Hisata, S. and Racanelli, A.C. and Kermani, P. and Schreiner, R. and Houghton, S. and Palikuqi, B. and Kunar, B. and Zhou, A. and McConn, K. and Capili, A. and Redmond, D. and Nolan, D.J. and Ginsberg, M. and Ding, B.-S. and Martinez, F.J. and Scandura, J.M. and Cloonan, S.M. and Rafii, S. and Choi, A.M.K., Reversal of emphysema by restoration of pulmonary endothelial cells, Journal of Experimental Medicine, 218, (8), 2021Journal Article, 2021, DOI , URL
• Faherty, L. and Kenny, S. and Cloonan, S.M., Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD, Clinical science (London, England : 1979), 137, (3), 2023, p219-237Journal Article, 2023, DOI
• Cui, Y. and Gutierrez, S. and Ariai, S. and Ã-berg, L. and Thörn, K. and Gehrmann, U. and Cloonan, S.M. and Naessens, T. and Olsson, H., Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress, Frontiers in Immunology, 13, (998059), 2022Journal Article, 2022, DOI , URL
• Fan LC, McConn K, Plataki M, Kenny S, Williams NC, Kim K, Quirke JA, Chen Y, Sauler M, Möbius ME, Chung KP, Area Gomez E, Choi AM, Xu JF, Cloonan SM., Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD., JCI insight, 8, (16), 2023, pe163403Journal Article, 2023, DOI
• Salih MM, Robinson EK, Malekos E, Perez E, Capili A, Kim K, Zhang WZ, Cloonan SM, Carpenter S., LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages., American journal of respiratory cell and molecular biology, 68, (5), 2023, p511-522Journal Article, 2023, DOI
• Cloonan SM., "KEAP"ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease., American journal of respiratory and critical care medicine, 207, (8), 2023, p962-964Journal Article, 2023, DOI
• Kim K, Zhang WZ, Kikkers SA, O'Beirne SL, Strulovici-Barel Y, Kaner RJ, Crystal RG, Cloonan SM., Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease., American journal of respiratory cell and molecular biology, 68, (4), 2023, p458-462Journal Article, 2023, DOI
• Cuevas Ocaña S, El-Merhie N, Kuipers ME, Lehmann M, Enes SR, Voss C, Dean LSN, Loxham M, Boots AW, Cloonan SM, Greene CM, Heijink IH, Joannes A, Mailleux AA, Mansouri N, Reynaert NL, van der Does AM, Wagner DE, Ubags N., ERS International Congress 2022: highlights from the Basic and Translational Science Assembly., ERJ open research, 9, (2), 2023, p561-2022Journal Article, 2023, DOI
• Cloonan SM., OLA1 Phosphorylation: A Distress Signal from Damaged Endothelial Mitochondria?, American journal of respiratory cell and molecular biology, 68, (4), 2023, p347-348Journal Article, 2023, DOI
• Salih, M.M. and Robinson, E.K. and Malekos, E. and Perez, E. and Capili, A. and Kim, K. and Zhang, W.Z. and Cloonan, S.M. and Carpenter, S., LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages, American journal of respiratory cell and molecular biology, 68, (5), 2023, p511-522Journal Article, 2023, DOI , URL
• Cloonan, S.M., †KEAP†ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease, American Journal of Respiratory and Critical Care Medicine, 207, (8), 2023, p962-964Journal Article, 2023, DOI , URL
• Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70Journal Article, 2006, DOI
• Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888Journal Article, 2009, DOI
• Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031Journal Article, 2010, DOI , URL , TARA - Full Text
• Cloonan, S.M. and Williams, D.C. , The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 128, 2011, p1712 - 1723Journal Article, 2011
• Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507Journal Article, 2010, DOI
• Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, p686 - 688Journal Article, 2011, DOI , TARA - Full Text
• Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348Journal Article, 2011, DOI , URL , TARA - Full Text
• Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 133, (40), 2011, p15862 - 15865Journal Article, 2011, DOI
• Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926Journal Article, 2012
• Cloonan SM, Drozgowska A, Fayne D, Williams DC, The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters., Leukemia & lymphoma, 51, (3), 2010, p523-39Journal Article, 2010
• McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53Journal Article, 2014

• Title

  The Ironome of the Lung and Disease Pathogenesis
  Summary
  Funding Agency

  Science Foundation Ireland
  Date From

  2019
  Date To

  2024
• Title

  IRONWARS: The battle for IRON in the alveolar space underlies susceptibility to COPD
  Summary

  COPD is the most prevalent respiratory disease in adults affecting over 170 million people globally and tops all non-communicable respiratory diseases combined in mortality. While COPD is already the third leading cause of death worldwide, death rates from COPD are predicted to rapidly intensify due to a rising and ageing global population, outweighing any potential improvements in care. With little or no advances in therapy in decades, COPD is irreversible and inexorably progressive leading to a severe impairment in quality of life. Given the burden of COPD on human health, new and better personalised therapies are therefore desperately needed.
  Funding Agency

  Irish Research Council
  Date From

  01-01-2023

Biochemistry, Molecular & Cellular Biology, Immunity and Infection (including Rheumatology & Inflammatory disease), Respiratory Medicine,

• Weill Cornell Medicine, Junior Faculty Development Grant 2015
• Irish Association for Cancer Research Travel Award 2019
• Kellen Fellowship for Junior Faculty, Weill Cornell Medicine 2018
• Irish Research Council Laureate Award 2023
• Science Foundation ireland Future Research Leaders Award 2019
• National Cancer Institute/Health Research Board Ireland Molecular Prevention/Control Scholar 2009
• American Thoracic Society Annual Conference Best Abstract Award 2013 and 2014

• American Association for Cancer Research 2012
• American Thoracic Society current
• Irish Association for Cancer Research 2012
• Bioiron Society current
• European Respiratory Society current
• Irish Thoracic Society

• Programme Committee American Thoracic Society Assembly on Allergy, Immunology, and Inflammation (AII) This assembly is concerned with allergic, immunologic, and inflammatory mechanisms affecting the respiratory system in health and disease. 2023
• Conference Organising Committee Pittsburgh International Lung Conference Dublin 2023
• Nominating Committee, RCMB Assembly, American Thoracic Society 2022
• Associate Editor, Scientific Reports 2019
• CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference. Chair: Mitochondrial dysfunction and reprogramming in lung aging and disease. 2018
• CONFERENCE CHAIR/ORGANIZER European Respiratory Society Annual Conference 2019 Scientific Reviewer 2019
• Chair Assembly 3.02, Airway cell biology and immunopathology, European Respiratory Society 2022
• CONFERENCE CHAIR/ORGANIZER American Thoracic Society Annual Conference Program Committee 2017
• CONFERENCE ORGANIZER International Biorion Society Scientific Committee member 2019
• Associate Editor Respiratory Research 2018