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Selected Publications

Liver immunology and its role in inflammation and homeostasis. Robinson MW, Harmon C, O’Farrelly C. Cellular & Molecular Immunology (2016) 13, 267–276; doi:10.1038/cmi.2016.3

Natural Killer Cells and Liver Transplantation: Orchestrators of Rejection or Tolerance? Harmon C, Sanchez-Fueyo A, O'Farrelly C, Houlihan DD. Am J Transplant. 2016 Mar;16(3):751-7. doi: 10.1111/ajt.13565. Epub 2015 Dec 21. Review.

The microenvironment of visceral adipose tissue and liver alter natural killer cell viability and function. Conroy MJ, Fitzgerald V, Doyle SL, Channon S, Useckaite Z, Gilmartin N, O'Farrelly C, Ravi N, Reynolds JV, Lysaght J. J Leukoc Biol. 2016 Jun 30. pii: jlb.5AB1115-493RR. [Epub ahead of print]

CCR1 antagonism attenuates T cell trafficking to omentum and liver in obesity-associated cancer. Conroy MJ, Galvin KC, Kavanagh ME, Mongan AM, Doyle SL, Gilmartin N, O'Farrelly C, Reynolds JV, Lysaght J. Immunol Cell Biol. 2016 Jul;94(6):531-7. doi: 10.1038/icb.2016.26. Epub 2016 Apr 5. PMID: 27046081

CD141+myeloid dendritic cells are enriched in healthy human liver. (2013) Kelly A, Fahey R, Fletcher JM, Keogh C, Carroll AG, Siddachari R, Geoghegan J, Hegarty JE, Ryan J, O'Farrelly C. J Hepatol. [Epub ahead of print]

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes. (2013) Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C. FEBS Lett. 21;587(10):1571-8.

Endometrial aspiration biopsy: a non-invasive method of obtaining functional lymphoid progenitor cells and mature natural killer cells (2012) McMenamin M, Lysakova-Devine T, Wingfield M, O'Herlihy C, O'Farrelly C. Reprod Biomed Online. 25(3):322-8.

Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows. (2012) Foley C, Chapwanya A, Creevey CJ, Narciandi F, Morris D, Kenny EM, Cormican P, Callanan JJ, O'Farrelly C, Meade KG. BMC Genomics. 18;13:489.

Activation of human invariant natural killer T cells with a thioglycoside analogue of α-galactosylceramide. (2011) Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG. Clin Immunol. 140(2):196-207.

Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation. (2011) Ryan EJ, Stevenson NJ, Hegarty JE, O'Farrelly C. J Viral Hepat. 2011 Dec;18(12):840-51.

Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. (2011) Dring MM, Morrison MH, McSharry BP, Guinan KJ, Hagan R; Irish HCV Research Consortium, O'Farrelly C, Gardiner CM. Proc Natl Acad Sci U S A. 108(14):5736-41.

Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. (2011) Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A. Hepatology. 53(6):1846-53.

The differential evolutionary dynamics of avian cytokine and TLR gene classes. (2010) Downing T, Lloyd AT, O'Farrelly C, Bradley DG. J Immunol. 184(12):6993-7000.

Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. (2009) McGrath E, Ryan EJ, Lynch L, Golden-Mason L, Mooney E, Eogan M, O'Herlihy C, O'Farrelly C. Am J Reprod Immunol. 61(4):265-76.

Microanatomy of the liver immune system. (2009) Nemeth E, Baird AW, O'Farrelly C. Semin Immunopathol. 31(3):333-43.

Evidence of the adaptive evolution of immune genes in chicken. (2009) Downing T, Cormican P, O'Farrelly C, Bradley DG, Lloyd AT. BMC Res Notes. 2:254.

Divergent antimicrobial peptide (AMP) and acute phase protein (APP) responses to Trypanosoma congolense infection in trypanotolerant and trypanosusceptible cattle. (2009) Meade KG, O'Gorman GM, Hill EW, Narciandi F, Agaba M, Kemp SJ, O'Farrelly C, MacHugh DE. Mol Immunol. 47(2-3):196-204.

Invariant NKT cells and CD1d-positive cells amass in human omentum and are depleted in patients with cancer and obesity. Lynch, L, O'Shea, D, Winter, D, Geoghegan, J, Doherty, D and O'Farrelly, C (2009). Eur. J. Immunol. 39(7):1893-901.

Evolution, expression and effectiveness in a cluster of novel bovine beta-defensins. (2008) Cormican P, Meade KG, Cahalane S, Narciandi F, Chapwanya A, Lloyd AT, O'Farrelly C. Immunogenetics. 60(3-4):147-56.

Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta. (2008) Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C, Mills KH. J Immunol. 181(7):4485-94.

Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure. (2008) Golden-Mason L, Madrigal-Estebas L, McGrath E, Conroy MJ, Ryan EJ, Hegarty JE, O'Farrelly C, Doherty DG. Gut. 57(8):1121-8.

Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. (2007) Golden-Mason L, Castelblanco N, O'Farrelly, Rosen HR. J Virol. 81(17):9292-8.

Cells with haematopoietic stem cell phenotype in adult human endometrium: relevance to infertility? (2007) Lynch L, Golden-Mason L, Eogan M, O'Herlihy C, O'Farrelly C. Hum Reprod. 22(4):919-26.