Selected Publications

7.10 MAG. A Novel Host Monoacylglyceride for In Meso (Lipid Cubic Phase) Crystallization of Membrane Proteins

Krawinski, P., Smithers, L., van Dalsen, L., Boland, C., Ostrovitsa, N., Perez, J., Caffrey, M.

Crystal Growth & Design 24, 2985–3001. (2024) Article

Se-MAG Is a Convenient Additive for Experimental Phasing and Structure Determination of Membrane Proteins Crystallised by the Lipid Cubic Phase (In Meso) Method.

Boland, C., Huang, C.-Y., Kaki, S.S., Wang, M., Olieric, V., and Caffrey, M. 

Crystals 13, 1402 (2023) Article

Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.

Malwal SR, Mazurek B, Ko J, Xie P, Barnes C, Varvitsiotis C, Zimmerman MD, Olatunji S, Lee J, Xie M, Sarathy J, Caffrey M, Strynadka NCJ, Dartois V, Dick T, Lee BNR, Russell DG, and Oldfield E.

J. Med. Chem. 66 , 7553–7569,  (2023) Article

Structure snapshots reveal the mechanism of a bacterial membrane lipoprotein N-acyltransferase.

Smithers, L., Degtjarik, O., Weichert, D., Huang, C.Y., Boland, C., Bowen, K., Oluwole, A., Lutomski, C., Robinson, C.V., Scanlan, E.M., Wang, M., Olieric, V., Shalev-Benami, M., and Caffrey, M.

Science Advances 9,  (2023) Article

Thromboxane A2 G Protein-Coupled Receptor Production and Crystallization for Structure Studies.

Krawinski, P. and Caffrey, M.

In: Mus-Veteau, I. (eds) Heterologous Expression of Membrane Proteins. Methods in Molecular Biology, vol 2507. pp 241–271. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2368-8_13 Article

The SARS-CoV-2 envelope (E) protein forms a calcium- and voltage-activated calcium channel.

Antonides, L.H., Hurst, Q.W., Ives, C.M., Ramberg, K., Ostrovitsa, N., Scanlan, E., Caffrey, M., Pitt, S.J. and Zachariae, Z.

bioRxiv 11 October 2022. Article

Bacterial Lipoprotein Posttranslational Modifications. New Insights and Opportunities for Antibiotic and Vaccine Development.

Smithers, L., Olatunji, S. and Caffrey M.

Front. Microbiol., 07 December 2021. Article

Membrane protein crystallization.

Caffrey M.

Bergfors T. M. (ed.) Protein Crystallization. 3rd Edition (Ebook), IUL Biotechnology Series, 10. Chapter 19, pp 373-410. ISBN: 978-0-9720774-7-7. (2021) eBook

Structural basis of the membrane intramolecular transacylase reaction responsible for lyso-form lipoprotein synthesis.

Olatunji, S., Bowen, K., Huang, C.Y., Weichert D., Singh W., Tikhonova I.G., Scanlan E.M., Olieric V. and Caffrey M.

Nat Commun 12, 4254 (2021) Article

Low-dose in situ prelocation of protein microcrystals by 2D X-ray phase-contrast imaging for serial crystallography.

Martiel I., Huang C.Y.,  Villanueva-Perez P., Panepucci P.E., Basu S., Caffrey M.,  Pedrini B., Bunk O., Stampanoni M. and Wang, M.

IUCrJ. (2021)7:1131-1141 Article

Undecaprenol kinase: Function, mechanism and substrate specificity of a potential antibiotic target.

Baker B.R., Ives C.M., Bray A., Caffrey M. and Cochrane S.A.

Eur. J. Med. Chem. (2021) 210 Article

9.8 MAG: A New Host Lipid for In Meso (Lipid Cubic Phase) Crystallization of Integral Membrane Proteins.

van Dalsen L., Smithers L., Boland C., Weichert D. and Caffrey M.

Cryst. Growth Des. (2020) Article

3D-printed holders for in meso in situ fixed-target serial X-ray crystallography.

Huang CY., Meier N., Caffrey M., Wang M. and Olieric V.

J. Appl. Cryst. (2020) 53:854-859 Article

Effects of 2-monoacylglycerol on in meso crystallization and the crystal structures of integral membrane proteins.

Smithers L., van Dalsen L., Boland C., Reid G., Weichert D. and Caffrey M.

Cryst. Growth Des. (2020) Article

From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets.

Cochrane R.V.K., Alexander F.M., Boland C., Fetics S.K., Caffrey M. and Cochrane S.A.

Chemical Communications (2020) doi: 10.1039/D0CC03388J Article

Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase.

Li D. and Caffrey M.

J. Mol. Biol. (2020) Article

In meso crystallogenesis. Compatibility of the lipid cubic phase with the synthetic digitonin analogue, glyco-diosgenin.

van Dalsen L., Weichert D. and Caffrey M.

J. Appl. Cryst. (2020) 53:530-535 Article

In Meso In Situ Serial X-Ray Crystallography (IMISX): A Protocol for Membrane Protein Structure Determination at the Swiss Light Source.

Huang CY., Olieric V., Caffrey M., Wang M.

In: Perez C., Maier T. (eds) Expression, Purification, and Structural Biology of Membrane Proteins. Methods in Molecular Biology, vol 2127. Humana, New York, NY  https://doi.org/10.1007/978-1-0716-0373-4_20 (2020) Article

X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.

Thomaston J.L., Konstantinidi A., Liu L., Lambrinidis G., Tan J., Caffrey M., Wang J., Degrado W.F. and Kolocouris A.

Biochemistry (2020) 59:627–634  Article

Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin.

Olatunji, S., Yu, X., Bailey, J., Huang, C-Y., Zapotoczna, M., Bowen, K., Remškar, M., Müller, R., Scanlan, E. M., Geoghegan, J. A., Olieric, V. & Caffrey, M.

Nat Commun 11, 140 (2020) Article Behind the Paper

The Lipid Cubic Phase as a Medium for the Growth of Membrane Protein Microcrystals.

Al-Sahouri Z., Lee MY., Li D., Liu W. and Caffrey, M.

In: Boutet S., Fromme P., Hunter M. (eds) X-ray Free Electron Lasers. (2018) Springer, Cham Article

Membrane (and Soluble) Protein Stability and Binding Measurements in the Lipid Cubic Phase Using Label-free Differential Scanning Fluorimetry.

Boland, C., Olatunji, S., Bailey, J., Howe, N., Weichert, D., Fetics, S. K., Yu, X., Merino-Gracia, J., Delsaut, C. and Caffrey, M.

Analytical Chemistry (2018) 90:12152–12160 Article

In situ serial crystallography for rapid de novo membrane protein structure determination.

Huang, C-Y., Olieric, V., Howe, N., Warshamanage, R., Weinert, T., Panepucci, E., Vogeley, L., Basu, S., Diederichs, K., Caffrey, M. & Wang, M.

Communications Biology (2018) 1:124 Article

Practical Approaches for In Situ X-ray Crystallography: from High-throughput Screening to Serial Data Collection.

Martiel, I., Olieric, V., Caffrey, M. and Wang, M.

Protein Crystallography: Challenges and Practical Solutions. Chemical Biology (2018) 8:1-27. Ed. K. Beis, G. Evans. The Royal Society of Chemistry. Article

Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis.

El Ghachi, M., Howe, N., Huang, C-Y., Olieric, V., Warshamanage, R., Touzé, T., Weichert, D., Stansfeld, P. J., Wang, M., Kerff, F., Caffrey, M.

Nat. Commun. 9, 1078 (2018) Article Behind the Paper

Biophysical characterization and stabilization of detergent-solubilized lipoprotein N-acyl transferase from P. aeruginosa and E. coli

Weichert, D. & Caffrey, M.

Biochim. Biophys. Acta. (2018) 1860:1384-1393 Article

Proton movement and coupling in the POT family of peptide transporters.

Parker JL, Li C, Brinth A, Wang Z, Vogeley L, Solcan N, Ledderboge-Vucinic G, Swanson JMJ, Caffrey M, Voth GA, Newstead S.

Proc Natl Acad Sci U S A. (2017) doi: 10.1073/pnas.1710727114. PubMed Article

Editorial Overview: Membranes

Caffrey, M & Drew, D

Current Opinion in Structural Biology (2017) 45:vii-ix. doi: 10.1016/j.sbi.2017.08.004 Article

The cubicon method for concentrating membrane proteins in the cubic mesophase

Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK & Caffrey M.

Nature Protocols. (2017) 12, 1745–1762. doi:10.1038/nprot.2017.057 Pubmed Article Video

Structural insights into the mechanism of the membrane integral N-acyltransferase step in bacterial lipoprotein synthesis.

Wiktor M, Weichert D, Howe N, Huang CY, Olieric V, Boland C, Bailey J, Vogeley L, Stansfeld PJ, Buddelmeijer N, Wang M & Caffrey M.

Nat. Commun. (2017) 8:15952. doi: 10.1038/ncomms15952. Article Supplementary Material
Movie I Movie II

Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis.

Ghachi ME, Howe N, Auger R, Lambion A, Guiseppi A, Delbrassine F, Manat G, Roure S, Peslier S, Sauvage E, Vogeley L, Rengifo-Gonzalez JC, Charlier P, Mengin-Lecreulx D, Foglino M, Touzé T, Caffrey M, Kerff F.

Cell Mol Life Sci. (2017) 74: 2319–2332. Pubmed Article

Cell-Free Production of Membrane Proteins in Escherichia coli Lysates for Functional and Structural Studies.

Rues RB, Henrich E, Boland C, Caffrey M, Bernhard F.

Methods Mol. Biol. (2016) 1432:1-21. Article

Fast two-dimensional grid and transmission X-ray microscopy scanning methods for visualizing and characterizing protein crystals.

Wojdyla JA, Panepucci E, Martiel I, Ebner S, Huang CY, Caffrey M, Bunk O, Wang M.

J. Appl. Crystallogr. (2016) 49:944-952. Article

X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.

Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE.

Scientific Data. (2016) 3:160021. Article

Data-collection strategy for challenging native SAD phasing

Olieric V., Weinert T., Finke A.D., Anders C., Li D., Olieric N., Borca C.N., Michel O. Steinmetz M.O., Caffrey M., Jinek M. and Wang M.

Acta Cryst. (2016). D72, 421-429 Article

Structural basis of lipoprotein signal peptidase II action and inhibition by the antibiotic globomycin

Vogeley L., El Arnaout T., Bailey J., Stansfeld P.J., Boland C., Caffrey M.

Science (2016) 351, 876-880 Abstract Full Text Reprint Supplementary Material
Movie I Movie II Movie III Movie IV Movie V

In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures

Huang C.-Y., Olieric V., Ma P., Howe N., Vogeley L., Liu X., Warshamanage R., Weinert T., Panepucci E., Kobilka B., Diederichs K., Wang M. and Caffrey M.

Acta Cryst. (2016). D72, 93-112 Article Reprint Movie I Movie II Movie III Movie IV

Ternary structure reveals mechanism of a membrane diacylglycerol kinase

Li D., Stansfeld P.J., Sansom M.S.P., Keogh A., Vogeley L., Howe N., Lyons J.A., Aragao D., Fromme P., Fromme R., Basu S., Grotjohann I., Kupitz C., Rendek K., Weierstall U., Zatsepin N. A., Cherezov V., Liu W., Bandaru S., English N. J., Gati C., Barty A., Yefanov O., Chapman H. N., Diederichs K., Messerschmidt M., Boutet S., Williams G.J., Seibert M.M. & Caffrey M.

Nat. Commun. (2015). 6:10140. doi: 10.1038/ncomms10140. Article Press Release Free-Electron Laser Showcase

Crystal structure of rhodopsin bound to arrestin determined by femtosecond X-ray laser

Kang Y, Zhou XE Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MHE, Zhang C, Moeller A, West GM, Pascal B, Eps NV, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi XY, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad C, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JCH, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE

Nature (2015). 523, 561-567 Article News and Views Press Release

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

Stansfeld P.J., Goose J.E., Caffrey M., Carpenter E.P., Parker J.L., Newstead S., Sansom M.S.P.

Structure (2015). 23, 1350–1361 Article

In meso in situ serial X-ray crystallography of soluble and membrane proteins

Huang C.-Y., Olieric V., Ma P., Panepucci E., Diederichs K., Wang M. and Caffrey M.

Acta Cryst. (2015). D71, 1238-1256 Article Related Workshop Commentary Press Release

Gating Topology of the Proton-Coupled Oligopeptide Symporters

Fowler P.W., Orwick-Rydmark M., Radestock S., Solcan N., Dijkman P.M., Lyons J.A., Kwok J., Caffrey M., Watts A., Forrest L.R., Newstead S.

Structure (2015). 23, 290-301. Pubmed Article

Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method

Li D., Pye V. E. and Caffrey M.

Acta Cryst. (2015). D71, 104–122 Article

A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes

Caffrey, M.

Acta Cryst. (2015). F71, 3-18 Article

Fast native-SAD phasing for routine macromolecular structure determination

Weinert T., Olieric V., Waltersperger S., Panepucci E., Chen L., Zhang H., Zhou D., Rose J., Ebihara A., Kuramitsu S., Li D., Howe N., Schnapp G., Pautsch A., Bargsten K., Prota A.E., Surana P., Kottur J., Nair D.T., Basilico F., Cecatiello V., Pasqualato S., Boland A., Weichenrieder O., Wang B-C, Steinmetz M.O., Caffrey M. & Wang M.

Nat Methods (2014) doi:10.1038/nmeth.3211 Article

Cloning, expression, purification, crystallization and preliminary X-ray diffraction of a lysine-specific permease from Pseudomonas aeruginosa

Nji E., Li D., Doyle D. A. and Caffrey M.

Acta Cryst. (2014). F70, 1362-1367 Reprint Article

The lipid cubic phase or in meso method for crystallizing proteins. Bushings for better manual dispensing

Caffrey M, Eifert R, Li D, Howe N

J. Appl. Cryst. (2014) 47, 1804-1806 Reprint Article

A conformational landscape for alginate secretion across the outer membrane of Pseudomonas aeruginosa

Tan J., Rouse S.L., Li D., Pye V.E., Vogeley L., Brinth A.R., El Arnaout T., Whitney J.C., Howell P.L., Sansom M.S.P. and Caffrey M.

Acta Cryst. (2014). D70, 2054-2068 Pubmed Article Press Release Video 1 Video 2

Renaturing membrane proteins in the lipid cubic phase, a nanoporous membrane mimetic.

Li D, Caffrey M.

Sci Rep. 2014 Jul 24;4:5806. Pubmed Article

Cell-free expression and in meso crystallisation of an integral membrane kinase for structure determination.

Boland C, Li D, Shah ST, Haberstock S, Dötsch V, Bernhard F, Caffrey M.

Cell Mol Life Sci. 2014 71:4895-4910. Pubmed Article

Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters.

Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S.

EMBO Rep. 2014 15, 886–893. Pubmed Article

‘Hit and run’ serial femtosecond crystallography of a membrane kinase in the lipid cubic phase

Caffrey, M., Li, D., Howe, N., Syed S.T.A.

Phil. Trans. R. Soc. B. 369 20130621 Pubmed Article

172.

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

Li D, Howe N, Dukkipati A, Shah ST, Bax BD, Edge C, Bridges A, Hardwicke P, Singh OM, Giblin G, Pautsch A, Pfau R, Schnapp G, Wang M, Olieric V, and Caffrey M

Cryst. Growth Des. 14, 2034−2047 Pubmed Article

171.

Protein and Lipid Interactions Driving Molecular Mechanisms of in meso Crystallization.

Johner N, Mondal S, Morra G, Caffrey M, Weinstein H, and Khelashvili G

J. Am. Chem. Soc. 136: 3271-3284 Pubmed Article

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JCH, Doak RB, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Seibert MM, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M & Cherezov V (2014)

Nat. Commun. 5:3309. doi: 10.1038/ncomms4309. Pubmed Article

Crystallizing Membrane Proteins for Structure-Function Studies Using Lipidic Mesophases.

Caffrey, M.

Advancing Methods for Biomolecular Crystallography. NATO Science for Peace and Security Series A: Chemistry and Biology. R. Read et al. (eds), pp 33-46. Book Chapter

Serial femtosecond crystallography of G protein-coupled receptors.

Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah ST, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JC, Stevens RC, Cherezov V. (2013)

Science 342:1521-4. doi: 10.1126/science.1244142. Pubmed Article

Detergent-free mass spectrometry of membrane protein complexes.

Hopper JT, Yu YT, Li D, Raymond A, Bostock M, Liko I, Mikhailov V, Laganowsky A, Benesch JL, Caffrey M, Nietlispach D, Robinson CV.

Nat Methods. 10:1206-8. doi: 10.1038/nmeth.2691. Epub 2013 Oct 13. Pubmed Article

166.

Host Lipid and Temperature as Important Screening Variables for Crystallizing Integral Membrane Proteins in Lipidic Mesophases. Trials with Diacylglycerol Kinase.

Li, D., Shah, S.T.A., Caffrey, M.

Cryst. Growth Des. 13:2846-2857. Pubmed Article

165.

Crystal structure of the integral membrane diacylglycerol kinase.

Li, D., Lyons, A.J., Pye, V.E., Vogeley, L., Aragão, D., Kenyon, C.P., Shah, S.T.A., Doherty, C., Aherne, M., Caffrey, M.

Nature 49: 521-524. DOI 10.1038/nature12179 Pubmed Article News & Views

164.

A fast, simple and robust protocol for growing crystals in the lipidic cubic phase.

Aherne, M., Lyons, J.A., Caffrey, M.

J. Appl. Cryst. 45:1330-1333. Pubmed Article

163.

Why GPCRs behave differently in cubic and lamellar lipidic mesophases.

Khelashvili, G., Albornoz, P., Johner, N., Mondal, S., Caffrey, M., Weinstein, H.

J. Am. Chem. Soc. 134: 15858-15868. Pubmed Article

162.

Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography.

Li, D., Boland, C., Aragão, D., Walsh, K., & Caffrey, M.

J. Vis. Exp. 67: e4001.

Video Article: http://www.jove.com/video/4001

161.

Use of a robot for high-throughput crystallization of membrane proteins in lipidic mesophase.

Li, D., Boland, C., Walsh, K., & Caffrey, M.

J. Vis. Exp. 67: e4000.

Video Article: http://www.jove.com/video/4000

160.

Membrane protein structure determination using crystallography and lipidic mesophases: Recent advances and successes.

Caffrey, M., Li, D., Dukkipati, A.

Biochemistry 51: 6266-6288. Pubmed Article

159.

Structural insights into electron transfer in caa3-type cytochrome oxidase.

Lyons, JA, Aragão, D, Slattery, O, Pisliakov, AV, Soulimane, T, Caffrey, M.

Nature 487:514–518. doi: 10.1038/nature11182 Pubmed Article

158.

Preparation of 1-Monoacylglycerols via the Suzuki-Miyaura Reaction: 2,3-Dihydroxypropyl ( Z)-tetradec-7-enoate.

Yang, D, Cwynar, VA, Hart, DJ, Madanmohan, J, Lee, J, Lyons, J, Caffrey, M.

Org. Synth. 89: 183-201. Pubmed Article

157.

Crystal structure of the ß₂ adrenergic receptor–Gs protein complex.

Rasmussen, SGF, DeVree, BT, Zou, Y, Kruse, AC, Chung, KY, Kobilka, TS, Thian, FS, Chae, PS, Pardon, E, Calinski, D, Mathiesen, JM, Shah, STA, Lyons, JA, Caffrey, M, Gellman, SH, Steyaert, J, Skiniotis, G, Weis, WI, Sunahara, RK, Kobilka, B.K.

Nature 477:549-555. 2011 PubMed Article

156.

Fast fluorescence techniques for crystallography beamlines.

Stepanov, S., Hilgart, M., Yoder, D. W., Makarov, O., Becker, M., Sanishvili, R., Ogata, C. M., Venugopalan, N., Aragão, D., Caffrey, M., Smith, J. L., Fischetti, R. F.

J. Appl. Cryst. 44: 772-778. 2011 PubMed Article

155.

The Lipidic Cubic Phase as a Membrane Mimetic.

Hoefer, N., Aragão, D., Caffrey, M.

Biophys. J. 100:2075. 2011 Article

154.

Overview of ICCBM13.

Pye, V. E., Aragão, D., Lyons, J. A., Caffrey, M.

Cryst. Growth Des. In press. Article

153.

Crystallizing Membrane Proteins for Structure-Function Studies Using Lipidic Mesophases.

Caffrey, M.

Biochem. Soc. Trans. 39:725-732. 2011 PubMed Article

152.

The Lipidic Cubic Phase as a Membrane Mimetic for Integral Membrane Protein Enzymes.

Li, D., Caffrey, M.

Proc. Natl. Acad. Sci. USA. 108:8639-8644. 2011 PubMed Article

151.

Membrane Protein Crystallization in Lipidic Mesophases. Hosting lipid affects on the crystallization and structure of a transmembrane peptide.

Hofer, N., Aragão, D., J.A., Lyons, Caffrey, M.

Cryst. Growth Des. 11:1182-1192. 2011 Article

150.

Crystallizing Membrane Proteins in Lipidic Mesophases. A Host Lipid Screen

Li, D., Lee, J., Caffrey, M.

Cryst. Growth Des. 11:530-537. 2011 PubMed Article

149.

Structure and function of an irreversible agonist-b2 adrenoceptor complex.

Rosenbaum, DM, Zhang, C, Lyons, JA, Holl, R, Aragão, D., Arlow DH, Rasmussen, SGF, Choi, H-J, DeVree, BT., Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, Caffrey M, Gmeiner P, Kobilka BK. 2011.

Nature 469:236-240. 2011 PubMed Article

148.

Crystallizing membrane proteins for structure determination using lipidic mesophases.

Caffrey, M., Porter, C.

J. Vis. Exp. 45: e1712 , doi: 10.3791/1712. 2010 PubMed Online Video Article

147.

Crystallizing Transmembrane Peptides in Lipidic Mesophases.

Hoefer, N., Aragão, D., Caffrey, M.

Biophys. J. 99:L23-L25. 2010 PubMed Article

146.

The effect of calcium on the conformation of cobalamin transporter BtuB.

Luan, B., Carr, R., Caffrey, M., Aksimentiev, A.

Proteins. 78:1153-1162. (PMID: 19927326). 2010 PubMed Article

145.

Crystallizing Membrane Proteins In Lipidic Mesophases.

Caffrey, M., Cherezov, V.

Nature Protocols. 4:706-731. 2009. PubMed Article

144.

Crystallizing Membrane Proteins for Structure Determination. Use of Lipidic Mesophases.

Caffrey, M.

Annu. Rev. Biophysics. 38:29-51. 2009 PMID: 19086821 PubMed Article

143.

Monoacylglycerols. The Workhorse Lipids for Crystallizing Membrane Proteins in Mesophases.

Caffrey, M., Lyons, J., Smyth, T., and Hart, D.J.

In Current Topics in Membranes. Vol. 63. Ed. L. DeLucas. Burlington: Academic Press. pp. 83-108. 2009 Article

142.

On the Mechanism of Membrane Protein Crystallization in Lipidic Mesophases.

Caffrey, M.

Cryst. Des. Growth. 8:4244-4254. 2008 Article

141.

Insights into the Mode of Action of a Putative Zinc Transporter CzrB in Thermus thermophilus.

Cherezov, V., Hoefer, N., Szebenyi, D. M. E., Kolaj, O., Wall, J. G., Gillilan, R., Srinivasan, V., Jaroniec, C. P., Caffrey, M.

Structure. 16:1378-1388. 2008. PubMed Article

140.

In meso Crystal Structure and Docking Simulations Suggest an Alternative Proteoglycan Binding Site in the OpcA Outer Membrane Adhesin.

Cherezov, V., Liu, W., Derrick, J., Luan, B., Aksimentiev, A., Katrich, V., Caffrey, M.

Proteins. 71:24-34 2008 PubMed Article

139.

High resolution 1H NMR of a lipid cubic phase using a solution NMR probe.

Boyle-Roden, E., Hoefer, N., Dey, K. K., Grandinetti, P. J., Caffrey, M.

J. Magn. Res. 189:13–19. 2007 Article

138.

J. D. Bernal and the genesis of structural biology .

Caffrey, M.

J. Physics Conf. Ser. 57:17-28. 2007 Article

137.

Structural Refinement of the OpcA Adhesin Using Molecular Dynamics.

Luan, B., Caffrey, M., Aksimentiev, A.

Biophys. J. 93:3058-3069. 2007 PubMed Article

136.

Automatic mixing of viscous bio-samples.

Yuan L., Zheng, Y.F., Chen. W., and Caffrey, M.

Proc. IEEE Conference on Automation Science and Engineering, September 22-25, 2007, Scottsdale, AZ, pp. 634-639. 2007

135.

Crystallization and preliminary X-ray diffraction analysis of a soluble domain of the putative zinc transporter CzrB from Thermus thermophilus

Höfer, N., Kolaj, O., Li, H., Cherezov, V., Gillilan, R., Wall, J., Caffrey, M.

Acta Cryst. F 63: 673-677. 2007 PubMed Article

134.

High-throughput Automated System for Crystallizing Membrane Proteins in Lipidic Mesophases.

Peddi, A., Muthusubramaniam, L., Zheng, Y. F., Cherezov, V., Caffrey, M.

IEEE Trans. Automation Sci. Engin. 4(2) 129-140. 2007 Article

133.

A general robotic approach for high-throughput automation in the handling of biosamples.

Zheng, Y.F., Peddi, A. Muthusubramaniam, L., Cherezov, V., and Caffrey, M.

Life Science Automation - Fundamental and Applications. In Eds Zhang, M., Nelson, B., Felder, R., Artech House, Norwood, MA. Chapter 15, pp. 395-409. 2007

132.

Miniaturization and Automation for High-throughput Membrane Protein Crystallization in Lipidic Mesophases.

Cherezov, V., Caffrey, M.

Crystallization Strategies for Structural Genomics.In Ed. Chayen. N. pp. 169-194.S 2007

131.

Membrane Protein Crystallization in Lipidic Mesophases. A Mechanism Study Using X-ray Microdiffraction.

Cherezov, V., Caffrey, M.

Faraday Disc. 136:188-205. 2007 PubMed Article

130.

Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines.

Shaikh SR, Cherezov V, Caffrey M , Soni SP, LoCascio D, Stillwell W, Wassall SR. 2006

J. Am. Chem. Soc. 128:5375-5383. 2006 PubMed Article

129.

Interactions of tryptophan, tryptophan peptides and tryptophan alkyl esters at curved membrane interfaces.

Liu, W., Caffrey, M. 2006

Biochemistry 45: 11713-11726. 2006 PubMed Article

128.

Controlling the Passage of Light through Metal Microchannels by Nanocoatings of Phospholipids.

Teeters-Kennedy, S . M. , Rodriguez, K . R. , Rogers, T. M., Zomchek, K. A., Williams, S. M., Sudnitsyn, A, Carter, L., Cherezov, V., Caffrey, M., Coe, J. V.

J. Phys. Chem. B. 110, 21719-21727. 2006 PubMed Article

127.

Ultrafast hydration dynamics in the Lipidic cubic phase: Discrete water structures in nanochannels.

Kim, J., Lu, W., Qiu, W., Wang, L., Caffrey, M., Zhong, D.

J. Phys. Chem. B. 110: 21994-22000. 2006. PubMed Article

126.

In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution .

Cherezov, V., Yamashita, E., Liu, W., Zhalnina, M., Cramer, W. A., Caffrey, M.

J. Mol. Biol. 364:716-734. 2006 PubMed Article

125.

Picoliter-scale Crystallization of Membrane Proteins

Cherezov, V., Caffrey, M.

J. Appl. Cryst. 39:604-609. 2006 Article

124.

Room to move. Crystallizing membrane proteins in swollen lipidic mesophases.

Cherezov, V., Clogston, J., Papiz, M., Caffrey, M.

J. Mol. Biol. 357:1605-1618. 2006 PubMed Article

123.

The Membrane Protein Data Bank.

Raman, P., Cherezov, V., Caffrey, M.

Cell Mol. Life Sci. 63:36-51. 2006 PubMed

122.

Transmembrane Peptides Stabilize Inverted Cubic Phases in a Biphasic Length-dependent Manner: Implications for Protein-induced Membrane Fusion.

Siegel, D. P., Cherezov, V., Greathouse, D. V., Koeppe II, R. E., Killian, J. A., Caffrey, M.

Biophys. J. 90:200-211. 2006 PubMed Article

121.

Efficient and Effective Path for Automated Dispensing of Bio-Precipitant Solutions.

Peddi, A., Zheng, Y. F., Cherezov, V., Caffrey, M.

Proc. IEEE Conference on Automation Science and Engineering, Edmonton, Canada. 2005

120.

Controlling Release from the Cubic Phase. Amino acids, peptides, proteins and nucleic acids.

Clogston, J., Caffrey, M.

J. Controlled Release 107:97-111. 2005 PubMed Article

119.

Membrane protein crystallization in lipidic bicontinuous liquid crystals.

Caffrey, M.

Bicontinuous Structured Liquid Crystals In Surfactant Science Series. Vol. 127. Ed. Lynch, M., Spicer, P. T. pp.307-319. 2005 Article

118.

A simple and inexpensive nanoliter volume dispenser for highly viscous materials used in membrane protein crystallization.

Cherezov, V., Caffrey, M.

J. Appl. Cryst. 38:398-400. 2005 Article

117.

Gramicidin Structure and Disposition in Highly Curved Membranes.

Liu, W., Caffrey, M.

J. Struct. Biol. 150:23-40. 2005 PubMed Article

116.

Controlling Release from the Lipidic Cubic Phase by Selective Alkylation.

Clogston, J., Graciun, G., Hart, D. J., Caffrey, M.

J. Controlled Release 102:441-461. 2005 PubMed Article

115.

Automating the dispensing of viscous biomaterials

Peddi, A., Y. F. Zheng, V. Cherezov and M. Caffrey

Proc IROS 2: 1281-1286. 2004 Article

114.

Automating crystallization of membrane proteins by robot with soft coordinate measuring.

Muthusubramaniam, L., A. Peddi, Y. F. Zheng, V. Cherezov and M. Caffrey.

Proc ICRA 1450-1455. 2004 Article

113.

Membrane protein crystallization in lipidic mesophases with tailored bilayers.

Misquitta, L.V., Misquitta, Y., Cherezov, V., Slattery, O., Mohan, J. M., Hart, D., Zhalnina, M., Cramer, W. A., Caffrey, M.

Structure 12:2113-2124. 2004 PubMed Article

112.

Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation.

Wassall SR, Brzustowicz MR, Shaikh SR, Cherezov V, Caffrey M, Stillwell W.

Chem Phys Lipids132:79-88. 2004 PubMed Article

111.

Rational Design of Lipid for Membrane Protein Crystallization.

Misquitta, Y., Cherezov, V., Havas, F., Patterson, S., Mohan, J., Wells, A., Hart, D., Caffrey, M.

J. Struct. Biol.148:169-175. 2004 PubMed Article

110.

A Robotic System For Crystallizing Membrane And Soluble Proteins In Lipidic Mesophases.

Cherezov, V., Peddi, A., Muthusubramaniam, L., Zheng, Y.F. M. Caffrey.

Acta Cryst. D60: 1795-1807. 2004 PubMed

109.

Automating Crystal Harvesting and Mounting for High-Throughput Macromolecular Crystallography.

Chen, W., Peddi, A., Zheng, Y.F., Caffrey, M.

Proc. of the 5th World Congress on Intelligent Control and Intelligent Automation, June 14-18, Hangzhou, China. 2004

108.

Membrane Protein Crystallization.

Caffrey, M.

J. Struct. Biol. 142:108-132. 2003 PubMed Article

107.

Detergents Destabilize the Cubic Phase of Monoolein. Implications for Membrane Protein Crystallization.

Misquitta, Y., Caffrey, M.

Biophys. J. 85:3084-3096. 2003 PubMed Article

106.

Nano-volume Plates with Excellent Optical Properties for Fast, Inexpensive Crystallization Screening of Membrane Proteins.

Cherezov, V., Caffrey, M.

J. Appl. Cryst. 36:1372-1377. 2003 Article

105.

Interaction of Cholesterol with a Docosahexaenoic Acid Containing PE: Trigger for Microdomain/Raft Formation?

Shaikh, S. R., Cherezov, V., Caffrey, M., Stillwell, W., and Wassall, S. R.

Biochemistry. 42:12028-12037. 2003 PubMed Article

104.

The kinetics of non-lamellar phase formation in dope-me: relevance to biomembrane fusion

Cherezov, V., D. P. Siegel, W. Shaw, S. W. Burgess and M. Caffrey.

J. Memb. Biol. 195:165-182. 2003 PubMed

103.

Specific radiation damage can be used to solve macromolecular crystal structures.

Ravelli, R. B. G., Schrøder Leiros, H-K, Pan, B., Caffrey, M., McSweeney, S.

Structure 11:217-224. 2003 PubMed Article

102.

Biological Applications of Synchrotron Radiation: An Evaluation of the State of the Field in 2002. A BioSync Report.

Caffrey, M., Carter, C., Clardy, J., Hill, C., Maroney, M., Moore, P. (Chair), Stenkamp, R., Stevens, R.

Issued by the Structural Biology Synchrotron Users Organization. 2002 Report

101.

Membrane Protein Crystallization In Meso. Lipid Type-Tailoring of the Cubic Phase.

Cherezov, V. J. Clogston, Y. Misquitta, W. Abdel Gawad, M. Caffrey.

Biophys. J. 83:3393-3407. 2002 PubMed Article

100.

Unit Cell Volume Change as a Metric of Radiation Damage in Crystals of Macromolecules.

Ravelli, R. B. G., Theveneau, P, McSweeney, S., Caffrey, M.

J. Synchrotron Rad. 9:355-360. 2002 PubMed Article

99.

Controlling Membrane Cholesterol Content. A Role for Polyunsaturated (Docosahexaenoate) Phospholipids.

Brzustowicz, M. R., Cherezov, V., Zerouga , M., Caffrey, M., Stillwell, W., Wassall, S. R.

Biochemistry 41:12509-12519. 2002 PubMed Article

98.

An index of lipid phase diagrams.

Koynova, R., Caffrey, M.

Chem. Phys. Lipids. 115:107-219. 2002 PubMed Article

97.

Too hot to handle? Synchrotron x-ray damage of lipid membranes and mesophases.

Cherezov, V., K. M. Riedl and M. Caffrey.

J. Synchrotron Radiation. 9:333-341. 2002 PubMed Article

96.

Biophysical and Transfection Studies of the diC₁₄-Amidine/DNA Complex.

Cherezov, V., H. Qiu, V. Pector, M. Vandenbranden, J.-M. Ruysschaert and M. Caffrey.

Biophys. J. 82:3105-3117. 2002 PubMed Article

95.

Molecular Organization of Cholesterol in Polyunsaturated Membranes: Microdomain Formation.

Brzustowicz, M. R., V. Cherezov, M. Caffrey, W. Stillwell and S. R. Wassall.

Biophys. J. 82:285-298. 2002 PubMed Article

94.

Membrane form and function in finer focus.

Caffrey, M.

Current Opinions in Structural Biology. 2002 12:471-479. Article

93.

Structure and dynamic properties of membrane lipid and protein. Electrostatic Effects in Soft Matter and Biophysics.

Caffrey, M.

NATO Meeting/NATO ASI Series. 2001 46:1-26. (C. Holm et al. (eds.)) Kluwer Academic Publ. The Netherlands.

92.

Molecular Mechanism for the Crystallization of Bacteriorhodopsin in Lipidic Cubic Phases.

Nollert, P., H. Qiu, M. Caffrey, J. P. Rosenbusch, E. M. Landau.

FEBS Lett. 504:179-186. 2001 PubMed Article

91.

Rational Design Of Lipid Molecular Structure. A Case Study Involving The C19:1c10 Monoacylglycerol.

Misquitta, Y., and M. Caffrey.

Biophys. J. 2001 81: 1047-1058. PubMed Article

90.

Crystallization Screens: Compatibility with the lipidic cubic phase for in meso crystallization of membrane proteins.

Cherezov, V., Fersi, H., Caffrey, M.

Biophys. J. 81: 225-242. 2001 PubMed Article

89.

Direct Profiling and Reversibility of Ion Distribution at a Charged Membrane/Aqueous Interface: An X-ray Standing Wave Study.

Wang, J., Caffrey, M., Bedzyk, M., Penner, T.

Langmuir 17; 3671-3681. 2001 Article

88.

Phase behavior of a monoacylglycerol (Myverol 18-99K)/water system.

Clogston, J., Rathman, J., Tomasko, D., Walker, H., Caffrey, M.

Chem. Phys. Lipids 107:189-218. 2000 PubMed Article

87.

A lipid's eye view of membrane protein crystallization in mesophases.

Caffrey, M.

Current Opinions in Structural Biology 10:486-497. 2000 PubMed Article

86.

Crystallizing membrane proteins in lipidic mesophases. Detergent effects.

Ai, X., Caffrey, M.

Biophys. J. 79: 394-405. 2000 PubMed Article

85.

Biophysics and Synchrotron Radiation. Where the Marriage Fails. X-Ray Damage of Lipid Membranes and Mesophases.

Cherezov, V., Cheng, A., Petit, J-M, Diat, O., Caffrey, M.

Cell. Molec. Biology. 46:1133-1145. 2000 PubMed

84.

Phase diagram of the monoolein/water system. Equilibrium and metastability aspects.

Qiu, H., Caffrey, M.

Biomaterials. 21:223-234. 2000 PubMed Article

83.

Phase behavior of the monoerucin/water system.

Qiu, H., Caffrey, M.

Chem. Phys. Lipids. 100:55-79. 1999 PubMed

82.

Lyotropic and thermotropic phase behavior of hydrated monoacylglycerols: Structure characterization of monovaccenin.

Qiu, H. Caffrey, M.

J. Phys. Chem. B. 102:4819-4829. 1998 Article

81.

Phases and phase transitions of the phosphatidylcholines.

Koynova, R., Caffrey, M.

Biochim. Biophys. Acta. 1376:91-145. 1998 PubMed Article

80.

A Simple Mechanical Mixer for Small Viscous Lipid-Containing Samples.

Cheng, A., Hummel, B., Qiu, H., Caffrey, M.

Chem. Phys. Lett. 95:11-21. 1998 PubMed Article

79.

Membrane structure characterization using variable-period x-ray standing waves.

Zhang, R., Itri, R. Caffrey, M.

Biophys. J. 74, 1924-1936. 1998 PubMed Article

78.

Spatial resolution of the variable-period x-ray standing wave method as applied to model membranes.

Itri, R., Z hang, R., Caffrey, M.

Biophys. J. 73:1506-1515. 1997 PubMed Article

77.

Free radical mediated x-ray damage of model membranes.

Cheng, A., Caffrey, M.

Biophys. J. 70:2212-2222. 1996 PubMed Article

76.

Interlamellar Transition Mechanism in Model Membranes.

Cheng, A., Caffrey, M.

J. Phys. Chem. 100:5608-5610. 1996 Article

75.

The temperature-composition phase diagram and mesophase structure characterization of the monoolein/water system.

Briggs, J., Chung, H., Caffrey, M.

J. Physique II. France. 6:723-751. 1996 Article

74.

LIPIDAT: A database of lipid phase transition temperatures, enthalpy changes and associated information.

Caffrey, M., Koynova, R., Hogan, J, Moynihan, D.

Handbook of Nonmedical Applications of Liposomes. Vol. II. in (Eds. Y. Barenholz and D. D. Lasic) CRC Press. pp 85-104. 1996 Article

73.

Manipulating mesophase behavior of hydrated DHPE: An x-ray diffraction study of temperature and pressure effects.

Cheng, A., Mencke, A., Caffrey, M.

J. Phys. Chem. 100:299-306. 1996 Article

72.

X-Ray standing waves as probes of surface structure: Incident beam energy effects.

Kirchner, S., Wang, J., Yin, Z., Caffrey, M.

J. Appl. Physics. 78:2311-2322. 1995

71.

Membrane structure studies using x-ray standing waves.

Caffrey, M. and Wang, J.

Annu. Rev. Biophys. Biomol. Struct. 24:351-378. 1995 PubMed Article

70.

Phases and phase transitions of the hydrated sphingolipids.

Koynova, R., Caffrey, M.

Biochim. Biophys. Acta. 1255:213-236. 1995 PubMed Article

69.

Kinetics of lipid phase changes.

Caffrey, M., Cheng, A.

Current Opinions in Structural Biology. 5:548-555. 1995 PubMed Article

68.

Polymorphism, mesomorphism and metastability of monoelaidin in excess water.

Chung, H., Caffrey, M.

Biophys. J. 69:1951-1963. 1995 PubMed Article

67.

Locating calcium in membranes with x-ray standing waves.

Wang, J., Caffrey, M.

J. Am. Chem. Soc. 117:3304-3305. 1995 Article

66.

Structural changes in model membranes monitored by variable period x-ray standing waves.

Wang, J., Caffrey, M., Bedzyk, M. J. and Penner, T. L.

J. Phys. Chem. 98:10957-10968. 1994 PubMed Article

65.

Phases and phase transitions of the hydrated phosphatidylethanolamines.

Koynova, R. and Caffrey, M.

Chem. Phys. Lipids 69:1-34. 1994 PubMed Article

64.

Phases and phase transitions of the hydrated glycoglycerolipids.

Koynova, R. and Caffrey, M.

Chem. Phys. Lipids 69:181-207. 1994 PubMed Article

63.

The temperature-composition phase diagram and mesophase structure characterization of monopentadecenoin in water.

Briggs, J. and Caffrey, M.

Biophys. J. 67:1594-1602. 1994 PubMed Article

62.

Kinetics and mechanism of the barotropic lamellar gel/lamellar liquid crystal phase transition in fully hydrated DHPE: A time-resolved x-ray diffraction study using pressure-jump.

Cheng, A., Hummel, B., Mencke, A. and Caffrey, M.

Biophys. J. 67:293-303. 1994 PubMed Article

61.

The temperature-composition phase diagram of the monomyristolein in water: Equilibrium and metastability aspects.

Briggs, J. and Caffrey, M.

Biophys. J. 66:573-587. 1994 PubMed Article

60.

Structure characterization of membrane bound and surface adsorbed protein.

Wang, J. Wallace, C., Clark-Lewis, I. and Caffrey, M.

J. Mol. Biol. 237:1-4. 1994 PubMed Article

59.

The neutral area surface in cubic mesophases. Location and properties.

Chung, H. and Caffrey, M.

Biophys. J. 66:377-381. 1994 PubMed Article

58.

The curvature elastic energy function of the cubic mesophase.

Chung, H. and Caffrey, M.

Nature 368:224-226. 1994 PubMed Article

57.

Thermodynamics, thermomechanical and structure properties of an asymmetric phosphatidylcholine.

Zhu, T. and Caffrey, M.

Biophys. J. 65:939-954. 1993 PubMed Article

56.

X-Rays destroy the lamellar structure of model membranes.

Cheng, A-C., Hogan, J. L. and Caffrey, M.

J. Mol. Biol. 229:291-294. 1993 PubMed Article

55.

LIPIDAT A database of thermodynamic data and associated information on lipid mesomorphic and polymorphic transitions. 305 pp., 1331 references, 10,704 records each with 28 fields.

Caffrey, M

CRC Press, Inc., Boca Raton, FL. 1993 Book

54.

Mesophase transition temperatures as measured by fluorescence and calorimetry.

Koynova, R. and Caffrey, M.

Letter to the Editor, Biophys. J. 65:550. 1993 PubMed Article

53.

A simple apparatus for time-resolved x-ray diffraction studies utilizing static pressures and pressure-jumps up to 300 MPa.

Mencke, A., Cheng, A-C. and Caffrey, M.

Rev. Sci. Instrum. 64:383-389. 1993 Article

52.

Resonance enhanced x-rays in thin films: A structure probe for membranes and surface layers.

Wang, J., Bedzyk, M. J. and Caffrey, M.

Science. 258:775-778. 1992 PubMed Article

51.

Internal and interfacial structure of membranes using x-ray standing waves.

Caffrey, M. and Wang, J.

Faraday Discuss. 94:283-293. 1992 PubMed Article

50.

Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction.

Chung, H. and Caffrey, M.

Biophys. J. 63:438-447. 1992 PubMed Article

49.

Calorimetric and x-ray diffraction studies of the thermotropic behavior of hydrated rye cerebrosides.

Lynch, D. V., Caffrey, M., Hogan, J. and Steponkus, P. L.

Biophys. J. 61:1289-1300. 1992 PubMed Article

48.

LIPIDAT: A database of lipid phase transition temperatures and enthalpy changes. DMPC data subset analysis.

Caffrey, M. and Hogan, J.

Chem. Phys. Lipids. 61:1-109. 1992 PubMed Article

47.

Structural studies of membranes and surface layers up to 1,000 Å thick using x-ray standing waves.

Wang, J., Bedzyk, M. J., Penner, T. L. and Caffrey, M.

Nature. 354:377-380. 1991 PubMed Article

46.

Structure, thermodynamic and transport properties of biological liquid crystals studied by x-ray methods.

Caffrey, M.

Trends in Analytical Chemistry, 10:156-162. 1991 Article

45.

A database of lipid phase transition temperatures and enthalpy changes.

Caffrey, M., Moynihan, D. and Hogan, J.

J. Chem. Inform. Comp. Sci. 31:275-284. 1991 PubMed Article

44.

Kinetics of the barotropic ripple (P_b' ) - lamellar liquid crystal (L_a) phase transition in fully hydrated DMPC monitored by time-resolved x-ray diffraction.

Caffrey, M, Hogan J. L. and Mencke, A. P.

Biophys. J., 60:456-466. 1991 PubMed Article

43.

Diacetylenic lipid microstructures: Characterization by x-ray diffraction and calorimetry.

Caffrey, M., Hogan, J. L., and Rudolph, A. S.

Biochemistry, 30:2134-2146. 1991 PubMed Article

42.

Kinetics and mechanism of the pressure-induced lamellar order/disorder transition in DHPE: A time-resolved x-ray diffraction study.

Mencke, A. P., and Caffrey, M.

Biochemistry, 30:2453-2463. 1991 PubMed Article

41.

A database of lipid phase transition temperatures and enthalpy changes.

Caffrey, M., Moynihan, D. and Hogan, J.

Chem. Phys. Lipids 57:275-291. 1991 PubMed Article

40.

Kinetics of the premelting (L_b'-P _b') in hydrated DPPC: A time-resolved x-ray diffraction study using microwave-induced temperature-jumps.

Caffrey, M., Fanger, G., Magin, R. L., and Zhang, J.

Biophys. J. 58:677-686. 1990 PubMed Article

39.

Kinetics of the lamellar and hexagonal phase transitions in phosphatidyl-ethanolamine: A time-resolved x-ray diffraction study using a microwave-induced temperature-jump.

Caffrey, M., Magin, R. L., Hummel, B., and Zhang, J.

Biophys. J. 58:21-29. 1990 PubMed Article

38.

A centralized database for thermodynamic data on lipid mesomorphic phase transitions and miscibility.

Hogan, J. L., Moynihan, D., and Caffrey, M.

International CODATA Conference Proceedings. 1990 Article

37.

Diffuse-Double Layer at a Membrane/Aqueous Interface Measured with X-ray Standing Waves.

Bedzyk, M., Bommarito, M., Caffrey, M., and Penner, T. L.

Science 248:52-56. 1990 PubMed Article

36.

Water transport in lyotropic liquid crystals and lipid-water systems: Mutual diffusion coefficient determination.

Gerritsen, H. and Caffrey, M.

J. Phys. Chem. 94:944-948. 1990 Article

35.

A lyotrope gradient method for liquid crystal temperature-composition-mesomorph diagram construction using time-resolved x-ray diffraction.

Caffrey, M.

Biophys. J. 55:47-52. 1989 PubMed Article

34.

The study of lipid phase transition kinetics by time-resolved x-ray diffraction.

Caffrey, M.

Ann. Rev. Biophys. Biophys. Chem. 18:159-186. 1989 PubMed Article

33.

Physicochemical properties of biological liquid crystals using time-resolved x-ray diffraction.

Caffrey, M.

Workshop Proceedings - The Chemical Applications of Synchrotron Radiation. ANL/APS-TM-4: 147-153. 1989 Article

32.

Structural, mesomorphic and time-resolved studies of biological liquid crystals and lipid membranes using synchrotron radiation.

Caffrey, M.

Topics in Current Chemistry 151:75-109. 1989 Article

31.

X-ray standing waves: A molecular yardstick for biological membranes.

Bedzyk, M., Bilderback, D. H., Bommarito, M., Caffrey, M., and Schildkraut, J.

Science 241:1788-1791. 1988 PubMed Article

30.

Lipid-sugar interaction: Relevance to anhydrous biology.

Caffrey, M., Fonseca, V. and Leopold, A. C.

Plant Physiol. 86:754-758. 1988 PubMed Article

29.

Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils.

Caffrey, M. and Bywater, M.

J. Soc. Cosmet. Chem. 39:159-167. 1988 Article

28.

A crystalline lipid phase in a dry biological system: Evidence from x-ray diffraction analysis of Typha latifolia pollen.

Caffrey, M., Werner, B. G. and Priestley, D. A.

Biochim. Biophys. Acta 921:1214-1234. 1987 PubMed Article

27.

Uranyl acetate induces gel phase formation in model lipid and biological membranes.

Caffrey, M., Morris, S. J. and Feigenson, G. W.

Biophys. J. 52:501-505. 1987 PubMed Article

26.

Kinetics and mechanism of transitions involving the lamellar, cubic, inverted hexagonal and fluid isotropic phase of hydrated monoacylglycerides monitored by time-resolved x-ray diffraction.

Caffrey, M.

Biochemistry 26:6349-6363. 1987 PubMed Article

25.

The combined and separate effects of temperature and freezing on membrane lipid mesomorphic phase behavior: Relevance to cryobiology.

Caffrey, M.

Biochim. Biophys. Acta 896:123-127. 1987 PubMed Article

24.

Effect of chlorophyll a on the phase behavior of hydrated monogalactosyl diacylglyceride.

Dea, P., Pearson, L. T., Caffrey, M. and Chan, S.-I.

Biochim. Biophys. Acta 896:11-18. 1987 PubMed Article

23.

A temperature-gradient method for lipid phase diagram construction using time-resolved x-ray diffraction.

Caffrey, M. and Hing, F. S.

Biophys. J. 51:37-46. 1987 PubMed Article

22.

X-ray diffraction as a technique for studying the mesomorphic phase properties of lipids.

Caffrey, M.

In "Membranes, Metabolism and Dry Organisms", A. C. Leopold, ed., Cornell University Press, New York, pp. 350-357. 1986

21.

The influence of water on the phase properties of membrane lipids: Relevance to anhydrobiosis.

Caffrey, M.

In "Membranes, Metabolism and Dry Organisms", A. C. Leopold, ed., Cornell University Press, New York, pp. 242-258. 1986

20.

A lipid mesomorphic phase data compilation.

Caffrey, M.

Announcement, BioEssays 5:184. 1986 Article

19.

The Ca²⁺ induced phase transformation in soybean root microsomal membranes is a consequence of phospholipase activity.

Caffrey, M. and Lew, R. R.

Plant Cell Physiol. 27:1091-1100. 1986 Article

18.

Kinetics and mechanism of the lamellar gel/lamellar liquid crystal and lamellar/inverted hexagonal phase transition in phosphatidylethanolamine: A real-time x-ray diffraction study using synchrotron radiation.

Caffrey, M.

Biochemistry 24:4826-4844. 1985 PubMed Article

17.

X-Radiation damage of hydrated lecithin membranes detected by real-time x-ray diffraction using wiggler-enhanced synchrotron radiation as the ionizing radiation source.

Caffrey, M.

Nucl. Instr. Meth. 222:329-338. 1984 Article

16.

Real-time small-angle x-ray scattering during annealing of polymer single crystals.

Grubb, D. T., Liu J.-H, Caffrey, M. and Bilderback, D. H.

J. Polym. Sci. Polym. Phys. Ed. 22:367-378. 1984 Article

15.

Kinetics of the main phase transition of hydrated lecithin monitored by real-time x-ray diffraction.

Caffrey, M. and Bilberback, D. H.

Biophys. J. 45:627-631. 1984 PubMed Article

14.

The influence of metal ions on the phase properties of phosphatidic acid in combination with natural and synthetic phosphatidylcholines: An x-ray diffraction study using synchrotron radiation.

Caffrey, M. and Feigenson, G. W.

Biochemistry 23:323-331. 1984 PubMed Article

13.

Real-time x-ray diffraction using synchrotron radiation: System characterization and applications.

Caffrey, M. and Bilderback, D. H.

Nucl. Instr. Meth. 208:495-510. 1983 Article

12.

Biophysical characterization of lipid-protein and lipid-lipid interactions in model and reconstituted membranes using static and real-time x-ray diffraction and fluorescence quenching techniques.

Caffrey, M.

Ph.D. Thesis, (194 pages, 4 tables, 31 figures), Cornell University, Ithaca, New York 14853. 1982

11.

Fluorescence quenching in model membranes: The relationship between Ca²⁺-ATPase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics.

Caffrey, M. and Feigenson, G. W.

Biochemistry 20:1949-1961. 1981 PubMed Article

10.

Fatty acyl chain characteristics of phosphatidylcholines affect Ca²⁺-ATPase enzymatic activity but not the affinity of the protein for these different lipid species.

Caffrey, M. and Feigenson, G. W.

Biochem. Soc. Trans. 9:155-156. 1981 PubMed Article

9.

Solubilization of a micelle specific acyltransferase from rat mammary microsomes.

Caffrey, M. and Kinsella, J. E.

Int. J. Biochem. 9:381-384. 1978 PubMed Article

8.

Properties of palmitoyl-CoA: monopalmitoyl-sn-glycerol-3-phosphate palmitoyltransferase from rabbit mammary gland.

Caffrey, M. and Kinsella, J. E.

Int. J. Biochem. 9:239-248. 1978 PubMed Article

7.

Kinetics of a micelle specific palmitoyltransferase isoenzyme from rabbit mammary gland.

Caffrey, M. and Kinsella, J. E.

Lipids 12:556-562. 1977 PubMed

6.

Experimental difficulties in assaying a membrane-bound acyltransferase from rabbit mammary tissue.

Caffrey, M. and Kinsella, J. E.

Int. J. Biochem. 8:39-51. 1977 Article

5.

Growth and acyltransferase activity of rabbit mammary gland during pregnancy and lactation.

Caffrey, M. and Kinsella, J. E.

J. Lipid Res. 18:44-52. 1977 PubMed Article

4.

Isoenzymes of an acyltransferase from rabbit mammary gland: Solubilization of the micelle-specific species with Tritron X-100.

Caffrey, M. and Kinsella, J. E.

Biochem. Biophys. Res. Commun. 71:484-491. 1976 PubMed Article

3.

Properties of the palmityl-CoA:monopalmityl-sn-glycerol-3-phosphate palmityltransferases from mammary tissue.

Caffrey, M.

M.S. Thesis (278 pages, 11 tables, 55 figures), Cornell University, Ithaca, New York 14853. 1976

2.

Sensitivity of the molar absorptivity value to sample and instrument characteristics, with reference to the Ellman Reagent (DTNB).

Caffrey, M. and Kinsella, J. E.

Int. J. Biochem. 6:877-883. 1975 Article

1.

Isoenzymes of an acyltransferase from rabbit mammary gland: Evidence from biphasic substrate saturation kinetics.

Caffrey, M., Infante, J. and Kinsella, J. E.

FEBS Lett. 52:116-120. 1975 PubMed Article