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Dr. Adriele Prina Mello
Ussher Assistant Professor, Clinical Medicine

Biography

Adriele Prina-Mello, PhD, is an Ussher Assistant Professor in Translational Nanomedicine, Department of Clinical Medicine at the Trinity Translational Medicine Institute, School of Medicine. AMBER centre Investigator, CRANN Principal Investigator at Trinity College, Dublin. Chair of the working group in Characterization and Toxicology at the European Technology Platform for Nanomedicine. Expert Member of Nanosafety cluster, the EC Task Force in Characterization and European Materials Characterisation Council.

Founder and Director of the Laboratory for Biological Characterization of Advanced Materials, the Irish-branch of the European Nanomedicine Characterization Laboratory (EU-NCL), the flagship infrastructure project funded by the European Commission, in partnership with the US-National Cancer Institute Nano Characterization Laboratory)for enabling Translational Nanomedicine. My objective is to drive LBCAM to become a core nanomedicine enabling infrastructure for educational training (e.g., undergraduates, postgraduates) and international collaboration with academia, industry, clinicians and public bodies.

Prina-Mello's research interests are focused on the translation of nanotechnology-enabled products (e.g., medical device, medicinal drugs, hybrid products such as theranostics); advanced materials and their multifunctional solutions; device and instrumentation applications into the medical research area as Nanomedicine tools with the potential to become next generation medical standards or standards of care.

The key Nanomedicine areas of interest where I have developed expertise are: 1)Nanodiagnostics: advanced in vitro/ in vivo diagnostic and imaging devices and instrumentation. 2) Theranostics and Personalised Medicine: therapeutics based on nanotechnology and multilayered structures for localised and personalised medicine. 3) Regenerative Medicine: biomedical devices and nanotechnology and nanomaterials applied to tissue engineering. 4) Nanocharacterization and Safety: safe-by-design, responsible innovation development and regulatory compliance.

Credited with more than 70 peer-review publications, 6 book chapters, 2 Booklets (as editor), 2 Special Issue (as topic editor), 7 invited scientific reviews, > 25 invited lectures, >50 conference proceedings, >100 posters. (all indexed in Google Scholars, Research Gate, or RSS, April 2016)

Contributed to educational and learning by lecturing undergraduate students in Medicine and postgraduate Master degrees in Molecular Medicine, Translational Oncology, Pharmaceutical Science.

Since 2010 provided mentoring, educational training, and transferable skills to more than 15 students who are now accomplished professionals.

Prina-Mello's scientific and teaching international collaborators are the results of the extensive European Commission involvement and research projects activity.

Prina-Mello is an active member at TCD of the following: Trinity Cancer committee, AMBER/CRANN Environmental, Health, and Safety (EHS) platform, the TTMI TARGET Radiobiology group, the TTMI outreach committee, the TTMI Health and Safety, the Translational Child Health and Paediatrics forum, the St. James's Intensive Care Unit research group.

Publications and Further Research Outputs

Peer-Reviewed Publications

Murphy, F.A., Poland, C.A., Duffin, R., Al-Jamal, K.T., Ali-Boucetta, H., Nunes, A., Byrne, F., Prina-Mello, A., Volkov, Y., Li, S., Mather, S.J., Bianco, A., Prato, M., MacNee, W., Wallace, W.A., Kostarelos, K., Donaldson, K. , Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura , American Journal of Pathology, 178, (6), 2011, p2587 - 2600 Journal Article, 2011

Sanhaji M, Göring J, Couleaud P, Aires A, Cortajarena AL, Courty J, Prina-Mello A, Stapf M, Ludwig R, Volkov Y, Latorre A, Somoza Á, Miranda R, Hilger I., The phenotype of target pancreatic cancer cells influences cell death by magnetic hyperthermia with nanoparticles carrying gemicitabine and the pseudo-peptide NucAnt., Nanomedicine, 2019 Journal Article, 2019 DOI

Andrew R Collins, Balasubramanyam Annangi, Laura Rubio, Ricard Marcos, Marco Dorn, Carolin Merker, Irina Estrela‐Lopis, Mihaela Roxana Cimpan, Mohamed Ibrahim, Emil Cimpan, Melanie Ostermann, Alexander Sauter, Naouale El Yamani, Sergey Shaposhnikov, Sylvie Chevillard, Vincent Paget, Romain Grall, Jozo Delic, Felipe Goni-de-Cerio, Blanca Suarez-Merino, Valérie Fessard, Kevin N Hogeveen, Lise Maria Fjellsbø, Elise Runden Pran, Tana Brzicova, Jan Topinka, Maria João Silva, PE Leite, AR Ribeiro, JM Granjeiro, Roland Grafström, Adriele Prina-Mello, Maria Dusinska, High throughput toxicity screening and intracellular detection of nanomaterials., 2017 Review, 2017

Gobbo OL, Sjaastad K, Radomski MW, Volkov Y, Prina-Mello A, Magnetic Nanoparticles in Cancer Theranostics., Theranostics, 5, (11), 2015, p1249-63 Review, 2015 URL DOI TARA - Full Text

Multilayered Nanoparticles for Personalized Medicine: Translation into Clinical Markets in, editor(s)Bawa R., Audette G.F. and Rubinstein I. , Handbook of Clinical Nanomedicine - From Bench to Bedside, Singapore, Pan Stanford Publishing, 2016, [Movia D., Poland C., Tran L., Volkov Y., Prina-Mello A. ] Book Chapter, 2016

Bergamaschi E., Poland C., Poland C., Guseva Canu I., Guseva Canu I., Prina-Mello A., Prina-Mello A., The role of biological monitoring in nano-safety, Nano Today, 10, (3), 2015, p274 - 277 Journal Article, 2015 DOI

Multiparametric Preclinical Assessment of Theranostics Materials (Chapter 17) in, editor(s)Conde, Joao , Handbook of Nanomaterials for Cancer Theranostics, Elsevier, 2018, pp517 - 535, [Prina-Mello Adriele] Book Chapter, 2018 DOI URL

Kossatz S., Grandke J., Couleaud P., Latorre A., Aires A., Crosbie-Staunton K., Ludwig R., DÃ"hring H., Ettelt V., Lazaro-Carrillo A., Calero M., Sader M., Courty J., Volkov Y., Prina-Mello A., Villanueva A., Somoza à ., Cortajarena A., Miranda R., Hilger I., Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery, Breast Cancer Research, 17, (1), 2015 Journal Article, 2015 DOI

Marassi, Valentina and Di Cristo, Luisana and Smith, Stephen G J and Ortelli, Simona and Blosi, Magda and Costa, Anna L and Reschiglian, Pierluigi and Volkov, Yuri and Prina-Mello, Adriele, Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents, Royal Society open science, 5, (1), 2018, p171113 Journal Article, 2018 DOI TARA - Full Text

Caputo F, Clogston J, Calzolai L, Rösslein M, Prina-Mello A., Measuring particle size distribution of nanoparticle enabled medicinal products, the joint view of EUNCL and NCI-NCL. A step by step approach combining orthogonal measurements with increasing complexity., Journal of controlled release : official journal of the Controlled Release Society, 299, 2019, p31-43 Journal Article, 2019 DOI

Hole P, Sillence K, Hannell C, Maguire CM, Roesslein M, Suarez G, Capracotta S, Magdolenova Z, Horev-Azaria L, Dybowska A, Cooke L, Haase A, Contal S, Manø S, Vennemann A, Sauvain JJ, Staunton KC, Anguissola S, Luch A, Dusinska M, Korenstein R, Gutleb AC, Wiemann M, Prina-Mello A, Riediker M, Wick P, Interlaboratory comparison of size measurements on nanoparticles using nanoparticle tracking analysis (NTA)., Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 15, 2013, p2101 Journal Article, 2013

Alberti Marco, Prina-Mello Adriele, Smart model of intrinsic loss power of SPIONs in hyperthermia treatment, Journal of Magnetism and Magnetic Materials, 502, 2020, p166493- Journal Article, 2020 DOI URL

Oliveira H, Bednarkiewicz A, Falk A, Fröhlich E, Lisjak D, Prina-Mello A, Resch S, Schimpel C, Vr"ek IV, Wysoki"ska E, Gorris HH., Critical Considerations on the Clinical Translation of Upconversion Nanoparticles (UCNPs): Recommendations from the European Upconversion Network (COST Action CM1403)., Advanced healthcare materials, 8, (1), 2019, pe1801233 Journal Article, 2019 DOI

Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T, Silva MJ, Prina-Mello A, Movia D, Nesslany F, Ribeiro AR, Leite PE, Groenewold M, Cassee FR, Sips AJ, Dijkzeul A, van Teunenbroek T, Wijnhoven SW, Towards a nanospecific approach for risk assessment., Regulatory toxicology and pharmacology : RTP, 80, 2016, p46-59 Journal Article, 2016 TARA - Full Text DOI

Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, De La Chapelle M.L, Spadavecchia J, Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. the Golden Doxorubicin for Oncological Applications, ACS Applied Materials and Interfaces, 8, (31), 2016, p19946 - 19957 Journal Article, 2016 URL DOI

Gioria S, Caputo F, Urbán P, Maguire CM, Bremer-Hoffmann S, Prina-Mello A, Calzolai L, Mehn D., Are existing standard methods suitable for the evaluation of nanomedicines: some case studies., Nanomedicine (London, England), 2018 Journal Article, 2018 DOI

Prina-Mello A, Crosbie-Staunton K, Salas G, Del Puerto Morales M, Volkov Y. , Multiparametric toxicity evaluation of SPIONs by high content screening technique: Identification of biocompatible multifunctional nanoparticles for nanomedicine , IEEE Transactions on Magnetics, 49, (1), 2013, p377 - 382 Journal Article, 2013 DOI

Ignacio Martin-Loeches, Robert Forster, Adriele Prina-Mello, Intensive care medicine in 2050: nanotechnology. Emerging technologies and approaches and their impact on critical care, Intensive Care Medicine, 2017 Journal Article, 2017

Serena A. Corr, Aisling O' Byrne, Yurii K. Gun'ko, Swapankumar Ghosh, Dermot F. Brougham, Siobhan Mitchell, Yuri Volkov and Adriele Prina-Mello, Magnetic-fluorescent nanocomposites for biomedical multitasking, Chemical Communications, 43, 2006, p4474 - 4476 Journal Article, 2006 URL DOI

Gerlach JQ, Maguire CM, KrÃŒger A, Joshi L, Prina-Mello A, Griffin MD., Urinary nanovesicles captured by lectins or antibodies demonstrate variations in size and surface glycosylation profile., Nanomedicine (London, England), 12, (11), 2017, p1217-1229 Journal Article, 2017 DOI

Biomonitoring in, editor(s)Fadel B., Pietroiusti A., Shvedova A.A. , Adverse Effects of Engineered Nanomaterials, Academic Press, Elsevier Academic Press, 2016, pp125 - 160, [Bergamaschi E., Guseva Canu I, Prina-Mello A., Magrini A.] Book Chapter, 2016

Immunotoxicity and Safety Considerations for Iron Oxide Nanoparticles in, editor(s)Nguyen TK Thanh , Clinical Applications of Magnetic Nanoparticles: From Fabrication to Clinical Applications, Online, CRC press, 2018, pp273 - [Gary Hannon, Melissa Anne Tutty, Adriele Prina-Mello] Book Chapter, 2018

Moustaoui H, Saber J, Djeddi I, Liu Q, Movia D, Prina-Mello A, Spadavecchia J, Lamy de la Chapelle M, Djaker N., A protein corona study by scattering correlation spectroscopy: a comparative study between spherical and urchin-shaped gold nanoparticles., Nanoscale, 11, (8), 2019, p3665-3673 Journal Article, 2019 DOI

Crivelli B, Bari E, Perteghella S, Catenacci L, Sorrenti M, Mocchi M, Faragò S, Tripodo G, Prina-Mello A, Torre ML., Silk fibroin nanoparticles for celecoxib and curcumin delivery: ROS-scavenging and anti-inflammatory activities in an in vitro model of osteoarthritis., European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 137, 2019, p37-45 Journal Article, 2019 DOI

Prina-Mello, Adriele and Maguire, Ciaran Magus and Savage, John, Origins to Outcomes: A Role for Extracellular Vesicles in Precision Medicine, Precision Nanomedicine, 2018, p18--42 Journal Article, 2018

Advanced Methodologies and Techniques for Assessing Nanomaterials Toxicity: from manufacturing to nanomedicine screening in, editor(s)Nancy A. Monteiro-Riviere & C. Lang Tran , Nanotoxicology, Second Edition, Taylor & Francis, Informa Healthcare Books, CRC Press, 2013, pp155 - [Prina-Mello Adriele, Mohamed Bashir M, Verma Navin K, Jain Namrata, Volkov Yuri] Book Chapter, 2013

Di Cristo, L. and Maguire, C.M. and Mc Quillan, K. and Aleardi, M. and Volkov, Y. and Movia, D. and Prina-Mello, A., Towards the identification of an in vitro tool for assessing the biological behavior of aerosol supplied nanomaterials, International Journal of Environmental Research and Public Health, 15, (4), 2018 Journal Article, 2018 TARA - Full Text DOI

F Tian, A Prina-Mello, G G Estrada, A Beyerle, W Kreyling and T Stoeger, Cell shape imaging analysis: A fast and reliable technique for the investigation of internalised carbon nanotubes in flat macrophages, Journal of Physics: Conference Series, 151, 2009, p012033 - 012040 Journal Article, 2009 DOI URL

Prina_Mello, A, Farrell, E, Prendergast, PJ, Campbell, V, Coey, JMD, Effects of static magnetic fields on Primary cortical neurons, Physica Scripta, T118, 2005, p205 - 207 Journal Article, 2005 URL DOI

Moretti M., Prina_Mello A., Reid A.J., Barron V., Prendergast P.J. 2004. , Endothelial cell alignment on cyclically-stretched silicone surfaces., Journal of Materials Science: Materials in Medicine , 15, (10), 2004, p1159 - 1164 Journal Article, 2004 DOI URL

Prina-Mello A., Volkov Y., Kelleher D., Prendergast P.J., Comparative locomotory behaviour of T Lymphocytes versus T Lymphoma cells on flat and grooved surfaces., Annals of Biomedical Engineering. , 31, 2003, p1106 - 1113 Journal Article, 2003 DOI

Prina_Mello A., Bari M.A. Prendergast, P.J. , A comparison of excimer laser etching and dry etching process for surface fabrication of biomaterials., Journal of Materials Processing Technology , 124, 2002, p284 - 292 Journal Article, 2002 URL

Prina_Mello A., Prendergast P.J., Moretti M., Volkov Y. , Mechanical constraint of lymphatic cells: experimental analysis and model., Proceedings of the 15th AIMETA Congress of Theoretical and Applied Mechanics, , Taormina, Italy, 2001, ppMS_BIO_04. Conference Paper, 2001

Ciarán M. Maguire, Katherine Sillence, Matthias Roesslein, Claire Hannell, Guillaume Suarez, Jean-Jacques Sauvain, Sonja Capracotta, Servane Contal, Sebastien Cambier, Naouale El Yamani, Maria Dusinska, Agnieszka Dybowska, Antje Vennemann, Laura Cooke, Andrea Haase, Andreas Luch, Martin Wiemann, Arno Gutleb, Rafi Korenstein, Michael Riediker, Peter Wick, Patrick Hole and Adriele Prina-Mello, Benchmark of Nanoparticle Tracking Analysis on Measuring Nanoparticle Sizing and Concentration, Journal of Micro and Nano-Manufacturing, 5, (4), 2017, p041002-1 - 041002-10 Journal Article, 2017 TARA - Full Text URL DOI

Crotty D. Martinez G; Coey J.M.D., Prina-Mello A., Effect of 50Hz, 2mT AC electromagnetic field on proliferation, morphology and CBf-alpha1 protein expression in pre-osteoblast., Proceedings of the 30 th Annual Meeting of the Bioelectromagnetics Society , Bioelectromagnetics Society 30 th Annual Meeting , San Diego, June 2008, edited by BEMS , 1, BEMS, 2008, pp21- Conference Paper, 2008

Prina_Mello A., Volkov Y., Prendergast P.J. , Experimental analysis on normal and malignant lymphatic cells under topographical environments using a single-cell motion method., Proceedings of the IVth World Congress of Biomechanics., IVth World Congress of Biomechanics., Calgary (Canada), June 2002, 2002, ppCD-ROM proceedings Conference Paper, 2002

Mohamed BM, Boyle NT, Schinwald A, Murer B, Ward R, Mahfoud OK, Rakovich T, Crosbie-Staunton K, Gray SG, Donaldson K, Volkov Y, Prina-Mello A., Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials., Scientific Reports, 8, (679), 2018 Journal Article, 2018 URL TARA - Full Text

Prina_Mello A., Volkov Y., Prendergast P.J. , Experimental analysis on normal and malignant lymphocytes under topographical environments using a single-cell method. , Acta of Bioengineering and Biomechanics., European Society of Biomechanics, Wrozlaw, Poland, 1 , (4), 2003, pp186 - 187 Conference Paper, 2003

Prina-Mello A., Prendergast P.J., Volkov Y., T lymphatic cells response to microtextured surfaces: difference between HUT78 and PBTL cells, 5th International Conference in Cellular Engineering., Aachen, Germany, 2001, ppst_17 Conference Paper, 2001

Prina_Mello A. , Campbell V., and Coey J.M.D. , Static magnetic field effect in cells. A possible roa to cell differentiation., NSTI Nanotech 2005 , Anaheim, CA, May 2005, edited by NSTI , NSTI, 2005 Conference Paper, 2005

Cancer Nanotechnology, https://cancer-nano.biomedcentral.com/, BMC Springer Nature, [eds.], 2016 Editorial Board, 2016

REFINE project, REFINE 1st Knowledge Exchange Conference 2019, 3 Apr 2019, In:REFINE 1st Knowledge Exchange Conference 2019, 2019, Amsterdam, Simon Bacconnier Meetings /Conferences Organised, 2019

Prina-Mello A. , Volkov Y., and Prendergast P.J., Effect of microtopography and cell concentration on T lymphoid cell migration during in vitro extravasation process, NSTI Nanotech 2005, Anaheim, CA, May 2005, edited by NSTI , NSTI, 2005 Conference Paper, 2005 URL

Adriele Prina-Mello , CLINAM 2018, 4 Sept 2018, In:Workshop Sizing of Nanoparticles: From Regulatory and Metrology Aspects to Application and Analysis, 2018, Basel Switzerland, Jeff Clogston / Beat Loffler, Clinam Meetings /Conferences Organised, 2018

Prina_Mello A., Bioelectromagnetics 2005. Joint meeting of the American and European society of Bioelectromagnetics, 19-24 June, 2005, Dublin, (Sp 2005), 1, Bioelectromagnetics Meetings /Conferences Organised, 2005 URL

Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD, Influence of Strong Static Magnetic, Bioelectromagnetics, 27, (1), 2006, p35 - 42 Journal Article, 2006 URL

A. Prina-Mello, Z. Diao, and J.M.D. Coey, Nano-scale cell manipulation by magnetic field in the presence of functionalised magnetic carriers, Proceedings of Bioengineering in Ireland 12, Bioengineering in Ireland 12, Ireland, 27-28 January 2006, edited by McHugh, O'Mahony, Fitzpatrick , ISBN 1 905 254 075, The National Centre for Biomedical Engineering Science, 2006, pp73 - 74 Conference Paper, 2006

A. Prina-Mello, Z. Diao and J.M.D. Coey, Cell Separation and Manipulation by magnetic field in the presence of functionalised magnetic nanowires., Proceedings of NSTI Nanotech 2006 - BIONANO 2006, NSTI Nanotech 2006, Boston, USA, May 2006, edited by Ed. Laudon and Romanowicz , 1, (ISBN: 0-9767985-6-5), 2006, pp62 - 63 Conference Paper, 2006

A. Prina-Mello, Z. Diao, and J.M.D. CoeyA. Prina-Mello, Z. Diao, and J.M.D. Coey, Multilineage cell alignment and separation by magnetic field after internalization of nickel nanowires., Proceedings of the Scientific and Clinical Applications of Magnetic Carriers, Scientific and Clinical Applications of Magnetic Carriers, Austria, May 2006, edited by Hafeli, Schutt, Zborowski , 2006, pp41 - 42 Conference Paper, 2006

A. Prina-Mello, Z. Diao, and J.M.D. Coey, Osteoblast cell alignment by magnetic field after internalization of nickel nanowires, Proceeedings of the International Conference on Magnetism 06 , International Conference on Magnetism 06 , Kyoto, 20-25 August 2006, edited by ICM06 Editor committee , ICM06 - Publishers, 2006, pp64 - 64 Conference Paper, 2006

Taylor D, O'Brien F, Prina-Mello A, Ryan C, O'Reilly P, Lee TC , Compression data on bovine bone confirms that a "stressed volume" principle explains the variability of fatigue strength results. , Journal of Biomechanics, 32, (11), 1999, p1199 - 1203 Journal Article, 1999 URL DOI

Serena A Corr, Aisling O'Byrne, Yurii K Gun'ko, Swapankumar Ghosh, Dermot F Brougham, Siobhan Mitchell, Yuri Volkov, Adriele Prina-Mello, Magnetic-fluorescent nanocomposites for biomedical multitasking, Magnetic-fluorescent nanocomposites for biomedical multitasking. Chemical Communications, (43), 2006, p4474 - 4476 Journal Article, 2006

Daly R., Boland J.J., Donegan J., Cross G., Prina-Mello A. , Mechanistic insights from formation of novel pore morphologies with breath figure templating. , MRS annual proceedings, Materials Research Society (MRS) Annual Conference, Boston. MA, USA, December 2007, edited by Institute of Materials, Minerals and Mining (IOM3) , (1), Institute of Materials, Minerals and Mining (IOM3), 2007, ppff4.4- Conference Paper, 2007

Crotty D., Morgan J.P., Coey J.M.D., and A. Prina-Mello. (ed.), Osteoblast cell response to external stimulation after internalization of nickel nanowires. , Proceedings of the 13 th Bioengineering Ireland. The School of Mechanical and Aerospace Engineering, Belfast, ISBN 1-905254-18-0, 2007, Queen's University Belfast, 2007 Proceedings of a Conference, 2007

Prina-Mello A. , Daly R., Furlong C., Prendergast P.J., Boland J.J. , Investigation of cell biomimetic and mechano-response to biofunctionalised regular architecture microporous topographies., Proceedings of the 14 th International Conference on Solid Films and Surfaces (ICSFS), . 14 th International Conference on Solid Films and Surfaces (ICSFS), Dublin , edited by ICSF - IOM3 , 1, ICSFS , 2008, pp347- Conference Paper, 2008

Daly R., Boland J.J., Donegan J., Cross G., Prina-Mello A. , Mechanistic insights from formation of novel pore morphologies with breath figure templating. , Proceedings of the 14 th International Conference on Solid Films and Surfaces (ICSFS), 14 th International Conference on Solid Films and Surfaces (ICSFS), Dublin, 2008, 1, ICSFS, 2008, pp143- Conference Paper, 2008

Chun B.S., Walliang A.L., Fermon C, Byrne F., Prina-Mello A. , and J. M. D. Coey., Magnetic label detection in a microfluidic channel., Proceedings of the Joint European Magnetic Symposia, Joint European Magnetic Symposia, Dublin, September 2008, edited by Joint European Magnetic Symposia . , 1, Coey, Sanvito, 2008, ppBM10- Poster, 2008

Prina-Mello A. , Crotty D., Byrne F., Davey G. and J.M.D. Coey. , Cell alignment using a magnetic nanowire and external field gradient. , Proceedings of the Joint European Magnetic Symposia, Joint European Magnetic Symposia , Dublin , September 2008, edited by Joint European Magnetic Symposia , 1, Coey, Sanvito, 2008, ppBM11- Poster, 2008

Byrne F., Prina-Mello A. , Coey J.M.D., Mohamed B.M., Davies A,, Volkov Y. , Interaction of magnetic nickel nanowires with THP-1 cells and high content analysis of their cytotoxic effects. , Proceedings of the Scientific and Clinical Applications of Magnetic Carriers, Scientific and Clinical Applications of Magnetic Carriers, Vancouver, Canada, May 2008, edited by Hafeli, Schutt, Zborowski , 1, Hafeli, Schutt, Zborowski, 2008, pp175- Conference Paper, 2008

Byrne F., Prina-Mello A., Whelan A., Mohamed B.M., Davies A., Gun'ko Y.K., Coey J.M.D., Volkov Y., High content analysis of the biocompatibility of nickel nanowires , Journal of Magnetism and Magnetic Materials , 321, (10), 2009, p1341-1345 Journal Article, 2009 DOI

Prina-Mello A, Farrell E, Prendergast PJ, Campbell V, Coey JMD , Influence of strong static magnetic fields on primary cortical neurons , Bioelectromechanics, 27, 1, (Jan), 2006, p35 - 42 Journal Article, 2006

P.J.Cregg, Kieran Murphy, Adil Mardinoglu, Adriele Prina-Mello, Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting , Journal of Magnetism and Magnetic Materials, 322, (15), 2010, p2087-2094 Journal Article, 2010 DOI TARA - Full Text

Prina-Mello A. , Byrne F., Coey J.M.D.C, Mohamed B.M., Davies A., Volkov Y(ed.), High content screening analysis of proliferating MC3T3-E1 osteoblast cells in contact with nanowires: time dependence toxicological response., Proceedings of the 4 th International Conference on Bioengineering and Nanotechnology, Dublin, 1, July 2008, Nicholas Abbott and Gill Lee, 2008, 15 p Proceedings of a Conference, 2008

Prina-Mello A., Whelan A.M., Atzberger A., McCarthy J.E., Byrne F., Davies G.L., Coey J.M.D., Volkov Y., Gun'ko Y.K., Comparative Flow Cytometric Analysis of Immunofunctionalized Nanowire and Nanoparticle Signatures, Small, 6, (2), 2010, p247 - 255 Journal Article, 2010 DOI

Adriele Prina-Mello, High content screening analysis of proliferating MC3T3-E1 osteoblast cells in contact with nanowires: time dependence toxicological response , 4 th International Conference on Bioengineering and Nanotechnology, UCD, Dublin, July, 2008, Nicholas Abbott and Gill Lee Invited Talk, 2008

Prina-Mello A. , Byrne F., Coey J.M.D., Mohamed B.M., Davies A,, Volkov Y. , Time dependence nanomaterial toxicological response to proliferating MC3T3-E1 osteoblast cells: high content screening analisis. , Proceedings of the th International Conference on Particles, 9 th International Conference on Particles: Risks and Opportunities ., Cape Town, September 2008, edited by Gulumian , 1, Gulumian, 2008, pp50- Poster, 2008

Adil Mardinoglu, P.J. Cregg, Kieran Murphy, Maurice Curtin and Adriele Prina-Mello, Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targeting application, Journal of Magnetism and Magnetic Materials, 323, (3-4), 2010, p324-329 Journal Article, 2010 TARA - Full Text

Movia, D., Prina-Mello, A. , Volkov, Y. , Giordani, S, Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing, Chemical Research in Toxicology , 23, (9), 2010, p1459 - 1466 Journal Article, 2010 DOI TARA - Full Text

Toetsch S, Olwell P, Prina-Mello A, Volkov Y, The evolution of chemotaxis assays from static models to physiologically relevant platforms., Integrative biology : quantitative biosciences from nano to macro, 1, (2), 2009, p170-81 Journal Article, 2009 DOI

Corr SA, O'Byrne A, Gun'ko YK, Ghosh S, Brougham DF, Mitchell S, Volkov Y, Prina-Mello A, Magnetic-fluorescent nanocomposites for biomedical multitasking., Chemical communications (Cambridge, England), (43), 2006, p4474-6 Journal Article, 2006

Santos-Martinez, MJ, Medina, C, Prina-Mello, A, Conroy, J, Samuels, SP, Volkov, Y, Radomski, MW, A nanoscale resolution assay of flow-induced platelet microaggregation, Kardiochirurgia i Torakochirurgia Polska, 7, (4), 2010, p365-375 Journal Article, 2010 URL

Sasitharan Balasubramaniam, Noreen T. Boyle, Andrea Della-Chiesa, Frank Walsh, Adil Mardinoglu, Dmitri Botvich, Adriele Prina-Mello, Development of artificial neuronal networks for molecular communication, Nano Communication Networks, 2, (2-3), 2011, p150-160 Journal Article, 2011 TARA - Full Text

Bashir Mustafa Mohamed, Navin Kumar Verma, Adriele Prina-Mello, Yvonne Williams, Anthony M Davies, Gabor Bakos, Laragh Tormey, Connla Edwards, John Hanrahan, Anna Salvati, Iseult Lynch, Kenneth Dawson, Dermot Kelleher, and Yuri Volkov, Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity, Journal of Nanobiotechnology, 9, 2011, p29- Journal Article, 2011 TARA - Full Text

Darragh Crotty, Gary Silkstone, Soumya Poddar, Richard Ranson, Adriele Prina-Mello, Michael T. Wilson, and J. M. D. Coey, Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase, Proceedings of the National Academy of Sciences of the United States of America, 109, (18), 2012, p7126 Journal Article, 2012 TARA - Full Text

Movia D, Prina-Mello A, Bazou D, Volkov Y, Giordani S, Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models., ACS Nano, 5, (11), 2011, p9278-9290 Journal Article, 2011 DOI

Bashir Mustafa Mohamed, Dania Movia, Anton Knyazev, Dominique Langevin, Anthony Mitchell Davies, Adriele Prina-Mello, Yuri Volkov, Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes, Scientific Reports, 3, (1124), 2013, p1 - 7 Journal Article, 2013 DOI

Mohamed BM, Verma NK, Davies AM, McGowan A, Crosbie-Staunton K, Prina-Mello A, Kelleher D, Botting CH, Causey CP, Thompson PR, Pruijn GJ, Kisin ER, Tkach AV, Shvedova AA, Volkov Y, Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo., Nanomedicine (London, England), 7, (8), 2012, p1181-1195 Journal Article, 2012 DOI

Pini G., Scusa M.F., Congiu L., Benincasa A., Morescalchi P., Bottiglioni I., Di Marco P., Borelli P., Bonuccelli U., Della Chiesa A., Prina-Mello A., Tropea D., , IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients, Autism research and treatment , 01/2012, 2012 Journal Article, 2012 DOI

Anja Schinwald, Fiona A Murphy, Adriele Prina-Mello, Craig A Poland, Fiona Byrne, Dania Movia, James R Glass, Janet C Dickerson, David A Schultz, Chris E Jeffree, William Macnee, Ken Donaldson, The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma, Toxicological Sciences, 128, (2), 2012, p461 - 470 Journal Article, 2012 DOI

Santos-Martínez MJ, Prina-Mello A, Medina C, Radomski MW., Analysis of platelet function: role of microfluidics and nanodevices., Analyst, 136, (24), 2011, p5120 - 5126 Journal Article, 2011

Knyazev, A., Louise, L., Veber, M., Langevin, D., Filoramo, A., Prina-Mello, A., Campidelli, S, Selective adsorption of proteins on single-wall carbon nanotubes by using a protective surfactant , Chemistry - A European Journal, 17, (51), 2011, p14663 - 14671 Journal Article, 2011

McCarthy, J.E.*, Prina-Mello, A.*, Rakovich, T., Volkov, Y., Gun'Ko, Y.K, Fabrication and characterization of multimodal magnetic - Fluorescent polystyrene nanowires as selective cell imaging probes, Journal of Materials Chemistry, 21, (37), 2011, p14129 - 14225 Journal Article, 2011 DOI

Suzuki J., Balasubramaniam S. and Prina-Mello A, Multiobjective TDMA Optimization for Neuron-based Molecular Communication, BODYNETS 2012 , 7th International Conference on Body Area Networks. BODYNETS 2012 , Norway, 24-26 September 2012, edited by BODYNETS conference organisers , 2012, BODYNETS, 2012 Conference Paper, 2012

Samuel, S.P., Jain, N., O'Dowd, F., Paul, T., Kashanin, D., Gerard, V.A., Gun'ko, Y.K., Prina-Mello, A., Volkov, Y. , Nanoparticles uptake by human endothelial cells under shear flow, Proceedings of the 19th Bioengineering Ireland., 19th Bioengineering Ireland, Co. Meath, Dublin, 18-19 January 2013, edited by Kelly, Murphy, Buckley , The Trinity Centre for Bioengineering, 2013 Conference Paper, 2013

Mohamed BM, Movia D, Knyazev A, Langevin D, Davies AM, Prina-Mello A, Volkov Y, Citrullination as early-stage indicator of cell response to single-walled carbon nanotubes., Scientific reports, 3, 2013, p1124 Journal Article, 2013 DOI TARA - Full Text

McCarthy, J.E., Gun'Ko, Y.K., Volkov, Y.Rakovich, T., Prina-Mello, A., Rakovich, A., Byrne, S.J., Atzberger, A., , Application of nanomaterials in nanomedicine research, Proceedings of International Conference NANOMEETING 2011: Physics, Chemistry and Applications of Nanostructures - Reviews and Short Notes, NANOMEETING 2011: Physics, Chemistry and Applications of Nanostructures , Minsk; Belarus, 24-27 May, 2011, pp433-436 Conference Paper, 2011

Mohamed BM, Verma NK, Prina-Mello A, Williams Y, Davies AM, Bakos G, Tormey L, Edwards C, Hanrahan J, Salvati A, Lynch I, Dawson K, Kelleher D, Volkov Y, Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity., Journal of nanobiotechnology, 9, 2011, p29 Journal Article, 2011 DOI

Prina-Mello A., Farrell E., Prendergast P.J., Campbell V., Coey J.M.D. , Influence of Strong Static Magnetic Fields on Primary Cortical Neurons, Bioelectromagnetics, 27, (1), 2006, p35 - 42 Journal Article, 2006 DOI URL

A. Prina-Mello, Z. Diao and J.M.D. Coey, Internalization of ferromagnetic nanowires by different living cells, Journal of Nanobiotechnology, 4, (9), 2006, p1 - 11 Journal Article, 2006 TARA - Full Text DOI URL

Samuel SP, Jain N, O'Dowd F, Paul T, Kashanin D, Gerard VA, Gun'ko YK, Prina-Mello A, Volkov Y, Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow., International journal of nanomedicine, 7, 2012, p2943-56 Journal Article, 2012 DOI TARA - Full Text

Movia, D., Gerard, V., Maguire, C.M., Jain, N., Bell, A.P., Nicolosi, V., O'Neill, T., Scholz, D., Gun'ko, Y., Volkov, Y., Prina-Mello, A., A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells, Biomaterials, 35, (9), 2014, p2543-2557 Journal Article, 2014 DOI

Mahfoud, O.K., Rakovich, T.Y., Prina-Mello, A., Movia, D., Alves, F., Volkov, Y., Detection of ErbB2: Nanotechnological solutions for clinical diagnostics, RSC Advances, 4, (7), 2014, p3422-3442 Review, 2014 TARA - Full Text DOI

Singh, M., Movia, D., Mahfoud, O.K., Volkov, Y., Prina-Mello, A., Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts, European Journal of Nanomedicine, 5, (4), 2013, p195-204 Journal Article, 2013 DOI

Poland, C.A., Byrne, F., Cho, W.S., Prina-Mello, A., Murphy, F.A., Davies, G.L., Coey, J.M., Gounko, Y., Duffin, R., Volkov, Y., Donaldson, K., Lenghth dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal., Nanotoxicology, 2012, p899-911 Journal Article, 2012 DOI

Ajetunmobi,A. A., Prina-Mello,Adriele A., Volkov,Yuri Y., Corvin,Aiden P. A.P., Tropea,Daniela D., Nanotechnologies for the study of the central nervous system, Progress in Neurobiology, 123, 2014, p18-36 Journal Article, 2014 DOI TARA - Full Text

Ciaran Manus Maguire, Omar Kazem Mahfoud, Tatsiana Rakovich, Valerie Anne Gerard, Adriele Prina-Mello, Yurii Gun'ko, Yuri Volkov, Prina-Mello Adriele Prina-Mello Adriele Heparin conjugated quantum dots for in vitro imaging applications, Nanomedicine: Nanotechnology, Biology and Medicine, 10, (8), 2014, p1853 - 1861 Review Article, 2014

Sebastian Schwung, Andrii Rogov, Gareth Clarke, Cécile Joulaud, Thibaud Magouroux, Davide Staedler, Solène Passemard, Thomas Jüstel, Laurent Badie, Christine Galez, Jean Pierre Wolf, Yuri Volkov, Adriele Prina-Mello, Sandrine Gerber-Lemaire, Daniel Rytz, Yannick Mugnier, Luigi Bonacina, Ronan Le Dantec, Nonlinear optical and magnetic properties of BiFeO3 harmonic nanoparticles, Journal of Applied Physics, 116, (11), 2014, p114306- Journal Article, 2014

Rakovich TY, Mahfoud OK, Mohamed BM, Prina-Mello A, Crosbie-Staunton K, Van Den Broeck T, De Kimpe L, Sukhanova A, Baty D, Rakovich A, Maier SA, Alves F, Nauwelaers F, Nabiev I, Chames P, Volkov Y, Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in ling and breast cancer cells., tcd, 2014 Dataset, 2014 URL

Bianca M Rotoli, Rita Gatti, Dania Movia, Massimiliano G Bianchi, Luisana Di Cristo, Ivana Fenoglio, Fabio Sonvico, Enrico Bergamaschi, Adriele Prina-Mello, Ovidio Bussolati, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay, Nanotoxicology, 9, (2), 2015, p230-241 Journal Article, 2015 DOI

Shortt C., Edge D., Teughels S., Roskin E., Verbiest J., Gobbo O., Prina-Mello A., Volkov Y., Markos F., Bio-distribution of superparagmetic iron oxide nanoparticles (SPION's) in the pig (LB578), The FASEB Journal, 28, (1), 2014, pLB578- Journal Article, 2014

Harmonic Nanoparticles for Regenerative Research Authors, Flavio Ronzoni, Thibaud Magouroux, Remi Vernet, Jérôme Extermann, Darragh Crotty, Adriele Prina-Mello, Daniel Ciepielewski, Yuri Volkov, Luigi Bonacina, Jean-Pierre Wolf, Marisa Jaconi Publication date, JoVE (Journal of Visualized Experiments), (87), 2014, pe51333- Review Article, 2014

Gobbo O., Wetterling F., Vaes P., Teughels S., Markos F., Edge D., Shortt C., Crosbie-Staunton K., Radomski M., Volkov Y., Prina-Mello A., Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS, Nanomedicine, 10, (11), 2015, p1751-1760 Journal Article, 2015 DOI

Calero M., Chiappi M., Lazaro-Carrillo A., Rodríguez M., Chichón F., Crosbie-Staunton K., Prina-Mello A., Volkov Y., Villanueva A., Carrascosa J., Characterization of interaction of magnetic nanoparticles with breast cancer cells, Journal of Nanobiotechnology, 13, (1), 2015 Journal Article, 2015 DOI

Maguire C., Mahfoud O., Rakovich T., Gerard V., Prina-Mello A., Prina-Mello A., Gun'ko Y., Gun'ko Y., Volkov Y., Volkov Y., Heparin conjugated quantum dots for in vitro imaging applications, Nanomedicine: Nanotechnology, Biology, and Medicine, 10, (8), 2014, p1853-1861 Journal Article, 2014 DOI

Bianchi M., Allegri M., Costa A., Blosi M., Gardini D., Del Pivo C., Prina-Mello A., Di Cristo L., Bussolati O., Bergamaschi E., Titanium dioxide nanoparticles enhance macrophage activation by LPS through a TLR4-dependent intracellular pathway, Toxicology Research, 4, (2), 2015, p385-398 Journal Article, 2015 DOI

High Content Screening and Analysis with Nanotechnologies in, Alves F., Kiessling F. , Comprehensive Biomedical Physics - special isuse, Online , Science Direct, 2014, pp379 - 389, [Williams Y, Prina-Mello A, Volkov Y] Book Chapter, 2014

Martin-Loeches Ignacio, Muriel-Bombin Arturo, Ferrer Ricard, Artigas Antonio, Sole-Violan Jordi, Lorente Leonardo, Andaluz-Ojeda David, Prina-Mello Adriele, Herran-Monge Ruben, Suberviola Borja, The Protective Association Of Endogenous Immunoglobulins Against Sepsis Mortality Is Restricted To Patients With Moderate Organ Failure. , 2017 Working Paper, 2017

Volkov Yuri, McIntyre Jennifer, Prina-Mello Adriele, Graphene toxicity as a double-edged sword of risks and exploitable opportunities: A critical analysis of the most recent trends and developments , 2D Materials , 2016 Review, 2016 DOI

Samuel S., Santos-Martinez M., Medina C., Jain N., Radomski MW., Prina-Mello A., Volkov Y., CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility, International Journal of Nanomedicine, 10, 2015, p2723-2734 Journal Article, 2015 TARA - Full Text DOI

Schütz CA, Staedler D, Crosbie-Staunton K, Movia D, Chapuis Bernasconi C, Kenzaoui BH, Prina-Mello A, Juillerat-Jeanneret L, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles., International journal of nanomedicine, 9, 2014, p3481-98 Journal Article, 2014 DOI TARA - Full Text

Baird A, Easty D, Mohamed BM, Jarzabek M, Shiels L, Soltermann A, Raeppel S, McDonagh L, Clarke G, Crosbie-Staunton K, 56: Multiple RTK targeting as a therapeutic option in malignant pleural mesothelioma , Lung Cancer , 103 , 2017, pS26 - Journal Article, 2017

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E, Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences, 150, (1), 2016, p40-53 Journal Article, 2016 TARA - Full Text DOI

Doroudian M, O'Reilly C, Crosbie-Staunton K, MacLoughlin R, Prina-Mello A, Volkov Y, Donnelly SC, Good Things Come in Small Packages: An Aerosolized Delivery System for Small Molecule Inhibitors of Macrophage Migration Inhibitory Factor , 2016, 185 , SPRINGER LONDON LTD 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND , 2016, ppS467 - S468 Conference Paper, 2016

Edge D, Shortt CM, Gobbo OL, Teughels S, Prina-Mello A, Volkov Y, MacEneaney P, Radomski MW, Markos F, Pharmacokinetics and bio-distribution of novel super paramagnetic iron oxide nanoparticles (SPIONs) in the anaesthetized pig., Clinical and experimental pharmacology & physiology, 43, (3), 2016, p319-326 Journal Article, 2016

Staedler D, Passemard S, Magouroux T, Rogov A, Maguire CM, Mohamed BM, Schwung S, Rytz D, Jüstel T, Hwu S, Mugnier Y, Le Dantec R, Volkov Y, Gerber-Lemaire S, Prina-Mello A, Bonacina L, Wolf JP, Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles., Nanomedicine : nanotechnology, biology, and medicine, 11, (4), 2015, p815-24 Journal Article, 2015

Hassan R, Alley E, Kindler H, Antonia S, Jahan T, Grous J, Honarmand S, Mcdougall K, Whiting C, Nair N, 86 When RON MET TAM: potential interventions for mesothelioma therapy , 2016 Journal Article, 2016

Schwung Sebastian, Rogov Andrii, Clarke Gareth, Joulaud Cécile, Magouroux Thibaud, Staedler Davide, Passemard SolÃ"ne, JÃ"stel Thomas, Badie Laurent, Galez Christine, BiFeO3 nanocrystals for bio-imaging based on nonlinear optical harmonic generation , 2014 Working Paper, 2014

Laura Christine Kickham, Anthony M McElligott, Adriele Prina-Mello, Elisabeth A Vandenberghe, Yuri Volkov, Paul Browne, Interrogating the Interaction of CD52 Functionalised Metallic Nanoparticles with Malignant B Lymphocytes , Blood, 126 , (23 ), 2015 Journal Article, 2015 URL

Rotoli BM, Gatti R, Movia D, Bianchi MG, Di Cristo L, Fenoglio I, Sonvico F, Bergamaschi E, Prina-Mello A, Bussolati O, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay., Nanotoxicology, 9, (2), 2015, p230-41 Journal Article, 2015

Clark Gareth, Mugnier Yannick, Le Dantec Ronan, Gunko Yurii, Rytz Daniel, Galez Christine, Volkov Yu M, Prina-Mello Adriele, Phase pure, monocrystalline bismuth ferrite nanoparticles for biomedical applications , 2014, 2014 Conference Paper, 2014

Rakovich TY, Mahfoud OK, Mohamed BM, Prina-Mello A, Crosbie-Staunton K, Van Den Broeck T, De Kimpe L, Sukhanova A, Baty D, Rakovich A, Maier SA, Alves F, Nauwelaers F, Nabiev I, Chames P, Volkov Y, Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells., ACS nano, 8, (6), 2014, p5682-95 Journal Article, 2014

Ronzoni F, Magouroux T, Vernet R, Extermann J, Crotty D, Prina-Mello A, Ciepielewski D, Volkov Y, Bonacina L, Wolf JP, Jaconi M, Harmonic nanoparticles for regenerative research., Journal of visualized experiments : JoVE, (87), 2014 Journal Article, 2014

RAKOVICH T, PRINA-MELLO A, RAKOVICH A, BYRNE SJ, ATZBERGER A, MCCARTHY JE, GUN'KO YK, VOLKOV Y, APPLICATION OF NANOMATERIALS IN NANOMEDICINE RESEARCH , 2011, 3 , World Scientific , 2011, pp433 - Conference Paper, 2011

Martin-Loeches Ignacio, Muriel-Bombin Arturo, Ferrer Ricard, Artigas Antonio, Sole-Violan Jordi, Lorente Leonardo, Andaluz-Ojeda David, Prina-Mello Adriele, Herran-Monge Ruben, Suberviola Borja, The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure , Annals of Intensive Care , 7 , (1 ), 2017, p44 - Journal Article, 2017 TARA - Full Text

Maguire CM, Mahfoud OK, Rakovich T, Gerard VA, Prina-Mello A, Gun'ko Y, Volkov Y, Heparin conjugated quantum dots for in vitro imaging applications., Nanomedicine : nanotechnology, biology, and medicine, 10, (8), 2014, p1853-61 Journal Article, 2014

Spadavecchia J, Movia D, Moore C, Maguire CM, Moustaoui H, Casale S, Volkov Y, Prina-Mello A, Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies., International journal of nanomedicine, 11, 2016, p791-822 Journal Article, 2016 TARA - Full Text DOI

Gao Y, Mohamed BM, Prina-Mello A, O'Byrne KJ, Gray SG, 85 KAT5 and KDM6B may be candidate therapeutic targets in malignant pleural mesothelioma , Lung Cancer , 79 , 2013, pS30 - Journal Article, 2013

Catherine A Schütz, Davide Staedler, Kieran Crosbie-Staunton, Dania Movia, Catherine Chapuis Bernasconi, Blanka Halamoda Kenzaoui, Adriele Prina-Mello, Lucienne Juillerat-Jeannere, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles, International Journal of Nanomedicine, 9, 2014, p3481 - 3498 Journal Article, 2014 TARA - Full Text DOI

Ajetunmobi A, McAllister D, Jain N, Brazil O, Corvin A, Volkov Y, Tropea D, Prina-Mello A, Characterisation of SH-SY5Y Human Neuroblastoma cell growth over glass and SU-8 substrates., Journal of Biomedical Materials Research - Part A, 105, (8), 2017, p2129-2138 Journal Article, 2017 DOI

Walsh, F., Boyle, N.T., Mardinoglu, A., Chiesa, A.D., Botvich, D., Prina-Mello, A., Balasubramaniam, S., Artificial backbone neuronal network for nano scale sensors, 2011 IEEE Conference on Computer Communications Workshops, INFOCOM WKSHPS 2011, 2011, p449-454 Journal Article, 2011

McGovern, D.A., Daly, R., Prina-Mello, A., Boland, J.J., Porous polymer surfaces as a platform technology for biomaterials, 24th European Conference on Biomaterials - Annual Conference of the European Society for Biomaterials, 2011 Journal Article, 2011

Tian, F., Prina-Mello, A., Estrada, G., Beyerle, A., Möller, W., Schulz, H., Kreyling, W., Stoeger, T., Macrophage cellular adaptation, localization and imaging of different size polystyrene particles, Nano Biomedicine and Engineering, 1, (1), 2009, p13-26 Journal Article, 2009

A multidisciplinary approach to the study of T cell migration in, editor(s)Bradlow H.L., Castagnetta L., Massimo L., Zaenker K. , signal transduction and communication in cancer cells, New York, New York Academy of Sciences, 2004, pp313 - 319, [Long A., Mitchell S., Kashanin D., Williams V., Prina-Mello A., Shvets I.V., Kelleher D., Volkov Y.] Book Chapter, 2004 URL

Balasubramaniam, S., Teuscher, C., Botvich, D., Prina Mello, A., Role of Inter-Disciplinary Research in Nanoscale Communication, Nano Communication Networks, Elsevier, Elsevier, 2011 Book, 2011

Prina-Mello A., Bonacina L., Frontiers , Nature Publishing Group, Frontiers online, Nature Publishing Group, 2015 Book, 2015

Crotty, D., Silkstone, G., Poddar, S., Ranson, R., Prina-Mello, A., Wilson, M.T., Coey, J.M.D., Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 5, (1437-1442) DOI: 10.1073/pnas.1117840108), Proceedings of the National Academy of Sciences of the United States of America, 109, (18), 2012 Journal Article, 2012

Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Unraveling the Safety Profile of Nanoscale Particles and Materials - From Biomedical to Environmental Applications, InTech, 2018, [Movia D., Prina-Mello A.] Book Chapter, 2018 TARA - Full Text

Movia D., Di Cristo L., Alnemari R., McCarthy J. E., Moustaoui H., Lamy de la Chapelle M., Spadavecchia J., Volkov Y., Prina-Mello A., The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles, Journal of Interdisciplinary Nanomedicine, 2, (2), 2017, p110 - 130 Journal Article, 2017 DOI

Kuznetsova VA, Visheratina AK, Ryan A, Martynenko IV, Loudon A, Maguire CM, Purcell-Milton F, Orlova AO, Baranov AV, Fedorov AV, Prina-Mello A, Volkov Y, Gun'Ko YK., Enantioselective cytotoxicity of ZnS:Mn quantum dots in A549 cells., Chirality, 2017, p403-408 Journal Article, 2017 DOI

Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30 Journal Article, 2018 DOI

Tian F., Prina-Mello A., Estrada G.G., Beyerle A., Möller W., Schulz H., Kreyling W., Stöeger T. , A novel assay for the quantification of internalised nanoparticles in macrophages,, Nanotoxicology, 2, (4), 2008, p232 - 242 Journal Article, 2008 URL DOI

Special Issue on Role of Inter-Disciplinary Research in Nanoscale Communication , Nano Communication Networks, Elsevier, [eds.], 2011-2012 Editorial Board, 2011

Luisana Di Cristo, Sarah Mc Carthy, Keith Paton, Dania Movia, Adriele Prina-Mello, Interplay between oxidative stress and endoplasmic reticulum stress mediated- autophagy in unfunctionalised few-layer graphene-exposed macrophages, 2D Materials, 2018 Journal Article, 2018

Adriele Prina-Mello , Characterisation of particles in solution \textendash a perspective on light scattering and comparative technologies, Science and Technology of Advanced Materials, 2018 Journal Article, 2018 DOI

Adriele Prina-Mello and Dania Movia and Despina Bazou and Yuri Volkov and Adriele Prina-Mello, Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs, Scientific Reports, 2018, p12920- Journal Article, 2018 DOI TARA - Full Text

Clarke, G. and Rogov, A. and McCarthy, S. and Bonacina, L. and Gun'Ko, Y. and Galez, C. and Le Dantec, R. and Volkov, Y. and Mugnier, Y. and Prina-Mello, A., Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO3nanoparticles for harmonic bio-imaging, Scientific Reports, 8, (1), 2018 Journal Article, 2018 DOI TARA - Full Text

Cristina Multari, Marta Miola, Sara Ferraris, Dania Movia, Kristina Žužek Rožman, Nina Kostevšek, Antonia Follenzi, Enrica Verné, Adriele Prina-Mello, Synthesis and characterization of silica-coated superparamagnetic iron oxide nanoparticles and interaction with pancreatic cancer cells, International Journal of Applied Ceramic Technology, 2018 Journal Article, 2018

D Hutchinson, J Müller, JE McCarthy, Y Gun'ko, N Verma, X Bi, L Di Cristo, L Kickham, D Movia, A Prina-Mello, Y Volkov, AB0111"Cadmium nanoparticles citrullinate intracellular cytokeratins: cadmium potentially links rheumatoid arthritis to smoking and numerous working class occupations, Abstracts Accepted for Publication, 2017 Journal Article, 2017

The state-of-the-art in cartilage bioreactors. in, editor(s)PJ Prendergast, PE McHugh , Topics in Bio-Mechanical Engineering, Dublin, Trinity Centre for Bioengineering & National Centre for Biomedical Engineering Science, 2004, pp94 - 146, [McMahon LA, Barron V, Prina-Mello A, Prendergast PJ ] Book Chapter, 2004

Scientific Reports, https://www.nature.com/srep/, Springer Nature Publishing AG, [eds.], 2018 Editorial Board, 2018

Tereza Svadlakova, Frantisek Hubatka, Pavlina Turanek Knotigova, Pavel Kulich, Josef Masek, Jan Kotoucek, Jan Macak, Martin Motola, Martin Kalbac, Martina Kolackova, Radka Vankova, Petra Vicherkova, Andrea Malkova, Pavlina Simeckova, Yuri Volkov, Adriele Prina-Mello, Irena Kratochvilova, Zdenek Fiala, Milan Raska, Jan Krejsek, Jaroslav Turanek, Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes, Nanomaterials, 10, (3), 2020 Journal Article, 2020 DOI

Hannon Gary, Bogdanska Anna, Volkov Yuri, Prina-Mello Adriele, Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells, Nanomaterials, 10, (3), 2020 Journal Article, 2020 DOI

Moloney M. Brian, Gilligan E. Katie, Joyce P. Doireann, O'Neill P. Clodagh, O'Brien P. Killian, Khan Sonja, Glynn L. Claire, Waldron M. Ronan, Maguire M. Ciaran, Holian Emma, Naughton Erin, Elhadi Mohamed, Grealish B. Andrea, Malone Carmel, McDermott Emma, Dockery Peter, Ritter Thomas, Prina-Mello Adriele, Kerin J. Michael, Dwyer M. Roisin, Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer, Cells, 9, (1), 2020 Journal Article, 2020 DOI

Movia Dania, Bazou Despina, Prina-Mello Adriele, ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance, BMC Cancer, 19, (1), 2019, p854- Journal Article, 2019 DOI URL

Clogston Jeffrey D, Hackley Vincent A, Prina-Mello Adriele, Puri Sanyogitta, Sonzini Silvia, Soo Patrick Lim, Sizing up the Next Generation of Nanomedicines, Pharmaceutical Research, 37, (1), 2019 Review, 2019 URL DOI

Adriele Prina-Mello, Cancer Theranostics: a Translational Nanomedicine Perspective, BIONANOMED, Krems (Austria), 15 May 2017, 2017 Oral Presentation, 2017

Doroudian Mohammad, MacLoughlin Ronan, Poynton Fergus, Prina-Mello Adriele, Donnelly Seamas C, Nanotechnology based therapeutics for lung disease , Thorax , 74 , (10 ), 2019, p965 - Journal Article, 2019 DOI URL

Adriele Prina-Mello, First Generation Nanomedicine: lesson learned from the Characterization perspective, British Society for Nanomedicine Annual Young Researcher Event, Belfast, 11 Aug 2017, 2017 Oral Presentation, 2017

Adriele Prina-Mello, Next Generation Nanomedicine: lesson learned from the EU Nanomedicine Characterization Laboratory, Advanced School in Nanomedicine, 17th edition of the Summer School for Italian PhD students in Pharmaceutical Technology , Pula (Italy), 27-29 Sep 2017, 2017 Oral Presentation, 2017

Adriele Prina-Mello, The conceptual problems of nanomaterials application in translational medicine, 1st International School-conference for young researchers on Smart nanosystems for translation medicine, San Petersburg, Russia, 30 Nov 2017, 2017 Oral Presentation, 2017

Adriele Prina-Mello, FUTURE MEDICINE nanotechnology applied to medicine: an advanced tools to the benefit of patients. Trends, emerging technologies and impact to society , Open Campus: Future of Nanomedicine, Gratz, (Austria), 28 Feb 2018, 2018 Oral Presentation, 2018

Adriele Prina-Mello, EC Regulatory policies on the use of Nanomaterials in Nanomedicine and Risk Assessment, Kazan Medical School Symposium, Kazan, Russia, 15 Mar 2018, 2017 Oral Presentation, 2017

Adriele Prina-Mello, A Systematic Approach to Endotoxin Contamination Assessment of Iron Oxide Nanoparticles, Scientific and Clinical Application of Magnetic Nanocarriers, Copenhagen, Denmark, 24-27 May 2018, 2018 Oral Presentation, 2018

Giuseppina Sandri, Angela Faccendini, Marysol Longo, Marco Ruggeri, Silvia Rossi, Maria Cristina Bonferoni, Dalila Miele, Adriele Prina-Mello, Carola Aguzzi, Cesar Viseras, Franca Ferrari, Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing, Pharmaceutics, 12, (2), 2020, p179 Journal Article, 2020

Hannon, G. and Lysaght, J. and Liptrott, N.J. and Prina-Mello, A., Immunotoxicity Considerations for Next Generation Cancer Nanomedicines, Advanced Science, (1900133), 2019 Journal Article, 2019 TARA - Full Text DOI

Clarke, G., Rogov, A., McCarthy, S., Bonacina, L., Gun'ko, Y., Galez, C., Le Dantec, R., Volkov, Y., Mugnier, Y., Prina-Mello, A., Author Correction: Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO3 nanoparticles for harmonic bio-imaging (Scientific Reports, (2018), 8, 1, (10473), 10.1038/s41598-018-28557-w), Scientific Reports, 9, (1), 2019 Journal Article, 2019

Leong, H.S., Butler, K.S., Brinker, C.J., Azzawi, M., Conlan, S., Dufès, C., Owen, A., Rannard, S., Scott, C., Chen, C., Dobrovolskaia, M.A., Kozlov, S.V., Prina-Mello, A., Schmid, R., Wick, P., Caputo, F., Boisseau, P., Crist, R.M., McNeil, S.E., Fadeel, B., Tran, L., Hansen, S.F., Hartmann, N.B., Clausen, L.P.W., Skjolding, L.M., Baun, A., Ågerstrand, M., Gu, Z., Lamprou, D.A., Hoskins, C., Huang, L., Song, W., Cao, H., Liu, X., Jandt, K.D., Jiang, W., Kim, B.Y.S., Wheeler, K.E., Chetwynd, A.J., Lynch, I., Moghimi, S.M., Nel, A., Xia, T., Weiss, P.S., Sarmento, B., das Neves, J., Santos, H.A., Santos, L., Mitragotri, S., Little, S., Peer, D., Amiji, M.M., Alonso, M.J., Petri-Fink, A., Balog, S., Lee, A., Drasler, B., Rothen-Rutishauser, B., Wilhelm, S., Acar, H., Harrison, R.G., Mao, C., Mukherjee, P., Ramesh, R., McNally, L.R., Busatto, S., Wolfram, J., Bergese, P., Ferrari, M., Fang, R.H., Zhang, L., Zheng, J., Peng, C., Du, B., Yu, M., Charron, D.M., Zheng, G., Pastore, C., Publisher Correction: On the issue of transparency and reproducibility in nanomedicine (Nature Nanotechnology, (2019), 14, 7, (629-635), 10.1038/s41565-019-0496-9), Nature Nanotechnology, 14, (9), 2019, p902 Journal Article, 2019

S Inder, M Bates, N Ni Labhrai, N McDermott, J Schneider, G Erdmann, T Jamerson, AN Flores, A Prina-Mello, P Thirion, PR Manecksha, D Cormican, S Finn, T Lynch, L Marignol, Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance, Scientific Reports, 9, 2019, p1 - 12 Journal Article, 2019 DOI TARA - Full Text

Fanny Caputo, Amandine Arnould, Maria Bacia, Wai Li Ling, Emilie Rustique, Isabelle Texier, Adriele Prina Mello, Anne-Claude Couffin, Measuring Particle Size Distribution by Asymmetric Flow Field Flow Fractionation: A Powerful Method for the Preclinical Characterization of Lipid-Based Nanoparticles, Molecular Pharmaceutics, 16, (2), 2019, p756-767 Journal Article, 2019 DOI

Prina-Mello Adriele, Translational requirements for nanotechnology enabled medical products, Magnetic nanoparticles and their applications in medicine conference, Belgrade, 4.03.2019, 2019, MAGBIOV and Vinca Institute Invited Talk, 2019

Prina-Mello Adriele, Challenges in translating a nano-thermal therapy to the clinic, Annual conference of the Italian Society of Photobiology, Bologna, 19-21 June 2019, 2019, italian society of photobiology Invited Talk, 2019

Prina-Mello Adriele, Regulatory Science Framework for Nanobiomaterials development - REFINE H2020 project update, NanoMed Europe 2019, Braga, 19-21 June 2019, 2019, ETP NANOMEDICINE Invited Talk, 2019

Prina-Mello Adriele, Translational Requirements for Nanotechnology enabled medical products: SPION case study, Nanoinnovation 2019, Rome, 11-14 June 2019, 2019, Nanoinnovation organising committee Invited Talk, 2019

Prina-Mello Adriele, Assay validation: irinotecan-based nanomedcine study, Controlled Release Society Annual event, Valencia, 21-24 July 2019, 2019, Controlled Release Society Invited Talk, 2019

Alberti Marco, Prina-Mello Adriele, Smart model of intrinsic popwer of SPIONS in hyperthermia treatment, International Conference on Magnetic Fluids - ICMF 2019, Paris, 8-12 July 2019, edited by ICMF 2019 , 2019 Poster, 2019

Prina-Mello Adriele, REFINE project establishing a regulatory science framework supporting the risk-benefit assessment of nanobiomaterial-based medical products and medical device, PTC 2019 - 12th International Particle Toxicology Conference , Salzburg, 11-13 September 2019, edited by International Particle Toxicology Conference Commitee , 2019 Poster, 2019

Precision Nanomedicine, Andover Massachusetts United States, Andover House, Inc., [eds.], 2018 Editorial Board, 2018 URL

Non-Peer-Reviewed Publications

Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016 Report, 2016

Prina_Mello A. , Trinity Bioelectromagnetics Seminar, 21 June, 2005, TCD, Dublin Meetings /Conferences Organised, 2005

A. Prina-Mello, Magneto-biology at the SFI Trinity Nanoscience Laboratory, Department of Bioimaging and Bioengineering - Tokyo University, February 10th 2006, 2006, Prof. Shoogo Ueno Invited Talk, 2006

A. Prina-Mello, Cell manipulation by magnetic field in the presence of functionalised magnetic nanowires , Nanotechnology seminar, MIT-Harvard University, Langer's La, Boston, USA, 10th May 2006, 2006, Dr. Lisa Freed Invited Talk, 2006

Prina-Mello A. , Byrne F., Whelan A., Mohamed B.M., Davies A., Gun'Ko Y., Coey J.M.D., Volkov Y. (ed.), Conference on Nanotechnology: implications for human health, the environment and food safety, Proceedings of the IST 2007 Conference on Nanotechnology, Dublin, 1, November 2007, DIT - Focas institute, 2007 Proceedings of a Conference, 2007

Prina-Mello A. , MULTIFUN Dissemination Booklet, TCD , Trinity College Dublin Publisher, 2014 Book, 2014 URL

Coey, Sanvito, Joint European Magnetic Symposia , 2008, In:Joint European Magnetic Symposia , 2008, Dublin , 1, Proceedings of the Joint European Magnetic Symposia Meetings /Conferences Organised, 2008

Prina-Mello A. and NAMDIATREAM consortium, NAMDIATREAM Dissemination Booklet, TCD, Trinity College Dublin Publisher, 2014 Book, 2014

Buckley C.T., Prina-Mello A., O'Kelly K.U., Development of biodegradable elastomeric scaffolds for mechanobiology investigations, Proceedings of the 11th Annual Conference of the Section of Bio-engineering of the Royal Academy of Medicine in Ireland, Galway, edited by FitzPatrick D.P. and Senouci M. , 2005, pp13- Oral Presentation, 2005

Santos-Martinez, M.J., Medina, C., Prina-Mello, A., Conroy, J., Samuels, S.P., Volkov, Y., Radomski, M.W., Nanobalance: a novel method for the measurement of flow-induced platelet aggregation, Nanomedicine: Seminar and Workshop, Centre for Research on Nanostructures and Nanodevices Trinity College Dublin, 29 June 2009, 2009 Poster, 2009

Adriele Prina-Mello, Yuri Volkov, Nanotechnology in Diagnostic, Monitoring and Treatment of Cancer Advanced in Molecular Imaging , 5-8 September 2012, In:World Molecular Imaging Congress 2012, 2012, Dublin, WMIS Meetings /Conferences Organised, 2012 URL

NANOMED 2018, NANOMED workshop, 3-4 Dec 2018, In:NANOMED workshop, 2018, Pavia, Italy Meetings /Conferences Organised, 2018

Adriele Prina-Mello, Nanosafety: The interface between industry, authorities and safety researchers, NETWORKING EVENT to ADVANCE NANOSAFETY in NORWAY , Oslo, 15.09.2016, 2016 Oral Presentation, 2016

Adriele Prina-Mello, Nanotechnology for cancer diagnostics , Cytometry Society of Ireland, TBSI, TCD, Dublin, 8 Nov 2016, 2016 Oral Presentation, 2016

Adriele Prina-Mello, NANOMATERIALS in MEDICINE: Structural And Physical-chemical aspects, Special NANO-Course-1 Nanomaterials, Nanotoxicology and Immunomodulation by Nanoparticles, Kazan, Russia, 14-17 Nov 2016, 2016 Oral Presentation, 2016

Adriele Prina-Mello, MULTIFUNCTIONAL NANOMATERIALS: Regulatory aspects and safe-by-design approach, Special NANO-Course-1 Nanomaterials, Nanotoxicology and Immunomodulation by Nanoparticles, Kazan, Russia, 14-17 Nov 2016, 2016 Oral Presentation, 2016

Adriele Prina-Mello, Exosome and Extracellular Vesicle Characterisation using Nanoparticle Tracking Analysis, NUIG REMEDI seminar, Galway, 1 dec 2016, 2016 Oral Presentation, 2016

Adriele Prina-Mello, TCD joint work toward First In Man: Advanced translational work, NANOGAGLIATO 2017, Gagliato (Italy), 25 Jul 2017, 2017 Oral Presentation, 2017

Adriele Prina-Mello, Charles University delegation visit to TCD, 6-7 Nov 2017, In:Charles University, Faculty of Medicine in Hradec Kralove, 2017, Dublin Meetings /Conferences Organised, 2017

Adriele Prina-Mello, Characterization in nanomedicine: Lesson learnt from the EUNCL (European Nanomedicine Characterisation Laboratory) and REFINE Project., 3rd Italian-Swedish Workshop on NanoBioMaterials - From safety assessment to biomedical uses, Turin (Italy), 22-23 Mar 2018, 2018 Oral Presentation, 2018

Adriele Prina-Mello, Development of liver 3D model as alternative to animals, Trinity Translational Medicine Institute Seminar, TTMI, TCD Dublin, 24 Apr 2018, 2018 Oral Presentation, 2018

Adriele Prina-Mello, NANOWOW 6 weeks course, May to June 2018, In:NANOWOW 6 weeks course, 2018, Dublin Meetings /Conferences Organised, 2018

Research Expertise

Description

Prina-Mello's research interests are focused on: 1) Advanced Translational Research of NanoMedicine (from Pre-clinical to Clinical, Precision, Personalised, Targeted nanomedicine), 2) Therapeutics based on nanotechnology and multilayered structures, 3) Theranostics and Personalised Medicine (in vitro/ in vivo diagnostic, imaging and treatment), 4) Dynamic interaction between nano-developed-products and biologically relevant models (nanotoxicology, nanobiocompatibility, nanosafety and nanobiotechnology), 5) Microfluidic systems applied to ultra-sensitive diagnostics (lab-on-a chip) 6) Biomedical devices and Tissue engineering applications of nanotechnology and nanomaterials, 7) Nanomedicine Characterization and Safety 8) In vitro complex models and tissue mimetic 9) Compliance to 3Rs principle 10) Development of Regulatory Science and Policy for nanotechnology-enabled medicine. Additional interests are also in pre-clinical screening, interdisciplinary science and research for nanomedicine and nanotechnology-based medical technology development (e.g., biomaterials, biocompatibility, high throughput and content screening, multiparametric analysys, data mining, bioelectromagnetisms biophysics, biomechanics, single cell assay and cellular engineering).

Projects

  • Title
    • SAFETY TESTING IN THE LIFE CYCLE OF NANOTECHNOLOGY-ENABLED MEDICAL TECHNOLOGIES FOR HEALTH
  • Summary
    • SAFE-N-MEDTECH will build an innovative open access platform to offer companies and reference laboratories, the capabilities, knowhow, networks and services required for the development, testing, assessment, upscaling and market exploitation of nanotechnology-based Medical and Diagnosis Devices. This across the whole Life Cycle of nano-enabled MTs.
  • Funding Agency
    • European Union
  • Date From
    • 1 April 2019
  • Date To
    • 31 Mar 2023
  • Title
    • EXpanding Platforms for Efficacious mRNA Therapeutics
  • Summary
    • EXPERT is to create an off-the-shelf mRNA-delivering nanomedicine platform that is manufactured via a quality-by-design approach that meet the requirements for GMP scaling up and clinical translation.
  • Funding Agency
    • European Union
  • Date From
    • 1 Jun 2019
  • Date To
    • 31 may 2023
  • Title
    • Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices
  • Summary
    • REFINE proposes a Regulatory Science Framework for the risk-benefit assessment of medical products and medical devices that are based on nanomedicines and biomaterials. The heart of our framework is the development of a product-specific Decision Support System that identifies the most efficient way to deliver the data required by regulation by the best-fitting methods. The decision tree will explicate the product's specific regulatory challenges and the priorities of both missing data and missing methods to match these challenges. It will thus allow planning a cost-and time efficient strategy both for necessary measurements and for the advancement of methods. Our approach is aligned with the industrial R&D practice of stage gating.
  • Funding Agency
    • European Union
  • Date From
    • 2017
  • Date To
    • 2021
  • Title
    • European Nanomedicine Characterisation Laboratory
  • Summary
    • To provide a trans-disciplinary testing infrastructure covering a comprehensive set of preclinical characterisation assays (physical, chemical, in-vitro and in-vivo biological testing) allowing researchers to fully comprehend the bio distribution, metabolism, pharmacokinetics, safety profiles and immunological effects of their Med-NPs.
  • Funding Agency
    • European Union
  • Date From
    • 2016
  • Date To
    • 2019
  • Title
    • Risk Management of Biomaterials
  • Summary
    • BIORIMA aims to develop an Integrated Risk Management (IRM) framework for NBM used in ATMP and MD. The BIORIMA IRM framework is a structure upon which the validated tools and methods for materials, exposure, hazard and risk identification/assessment and management are allocated plus a rationale for selecting and using them to manage and reduce the risk for specific NBM used in ATMP and MD.
  • Funding Agency
    • European Union
  • Date From
    • 2017
  • Date To
    • 2021
  • Title
    • NOCANTHER
  • Summary
    • Nanomedicine upscaling for early clinical phases of multimodal cancer therapy
  • Funding Agency
    • European Union
  • Date From
    • 2016
  • Date To
    • 2021
  • Title
    • NANOREG
  • Summary
    • The NANoREG project will establish a better level of trust between industry and policy developers and also establish a new, demand driven approach, involving the interaction of material specialists and nano-toxicologists. This will help to establish trust between the main players, namely regulators, scientific community and industry. With this project we will get not only a better coordination of the EU research agenda regarding the reduction of risk of nano materials, but improved or more focused interaction between industry, regulators and the scientific community.
  • Funding Agency
    • European Commission
  • Date From
    • 1/03/2013
  • Date To
    • 28/02/2017
  • Title
    • Amber centre Horizontal Platform
  • Summary
    • Horizontal Platform in Environmental Health and Safety (EHS) assessment of manufactured materials.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2013
  • Date To
    • 2018
  • Title
    • AMCARE FP7 project
  • Summary
    • AMCARE is a translational research program to develop advanced multimodal regenerative therapies using cardiopoeitic stem cells and smart biomaterials that effectively treat damage caused by acute myocardial infarction.
  • Funding Agency
    • European Commission
  • Date From
    • 1/11/14
  • Date To
    • 30/10/18
  • Title
    • IRC Postgraduate
  • Summary
    • Assessing the potential of nanomedicine to improve the diagnosis and treatment of pancreatic cancer
  • Funding Agency
    • Irish Research Council
  • Date From
    • 1/10/2016
  • Date To
    • 31/09/2019
  • Title
    • INEDITED
  • Funding Agency
    • Irish Research Council (IRC)
  • Date From
    • 1/10/2015
  • Date To
    • 31/09/2017
  • Title
    • MULTIFUN
  • Summary
    • The MULTIFUN consortium focuses on the development and validation of new systems based upon minimal invasive nanotechnology for the early and selective detection and elimination of breast and pancreatic cancer with reduced side effects. The project will deploy a strategy based on the multifuntionalisation of magnetic iron oxide nanoparticles (MNP), combining diagnostic and therapeutic features against breast and pancreatic cancer and cancer stem cells.
  • Funding Agency
    • European Commission
  • Date From
    • 13/6/2011
  • Date To
    • 12/6/2015
  • Title
    • NAMDIATREAM (EU-FP7-NMP LA)
  • Summary
    • NAMDIATREAM will develop nanotechnology-based toolkit to enable early detection and imaging of molecular biomarkers of the most common cancer types and of cancer metastases, as well as permitting the identification of cells indicative of early-stage disease onset. The project is built on the innovative technology concepts of super-sensitive "lab-on-a-bead", "lab-on-a-chip" and "lab-on-a-wire" nano-devices. Namdiatream is an interdisciplinary and Pan-european consortium that builds around 7 High-Tech SMEs, 2 Multinational industries and 13 academic institutions.
  • Funding Agency
    • EU FP7
  • Date From
    • 1/07/2010
  • Date To
    • 30/06/2014
  • Title
    • Quality NANO
  • Summary
    • QualityNano is a Research Infrastructure for nanosafety assessment. QualityNano's core aim is the creation of a 'neutral' scientific & technical space in which all stakeholder groups can engage, develop, and share scientific best practice in the field. Initially it will harness resources from across Europe and develop efficient, transparent and effective processes. Thereby it will enable provision of services to its users, and the broader community, all in the context of a best-practice ethos. This will encourage evidence-based dialogue to prosper between all stakeholders. However, QualityNano will also pro-actively seek to drive, develop and promote the highest quality research and practices via its Joint Research Activities (JRA), Networking Activities (NA) and provision of Transnational Access (TA) functions, with a global perspective and mode of implementation.
  • Funding Agency
    • European Commission
  • Date From
    • 1/02/11
  • Date To
    • 31/01/15
  • Title
    • Barcode project
  • Funding Agency
    • SFI
  • Date From
    • 1/09/2007
  • Date To
    • 31/12/2009

Keywords

Bioelectromagnetism; Bioengineering; Biomagnetism; Biomaterials; Biomechanics; Biomechanics, Biomedical Engineering; Biomedical Engineering; Biomedical sciences; Biophysics; Bioreactors; Biosensors; Biotechnology; Cell and tissue development; Cell Communication; Cytoskelton, cell division; Intra and intercellular signalling; Mechanical Engineering; Medical Devices Engineering; Microelectronics technology; Multisensory technology, multi sensing; Nano Biotechnology; Nano-Materials; Nanochemistry; NanoMedicine; Nanotechnology; Neurobiology; Stem Cell biology and hematopoiesis; Surface and interface physics; Tissue Culture

Recognition

Representations

Guest Associate Editor in Nanobiotechnology and Nanomedicine - Frontiers in Bioengineering and Biotechnology, Nanobiotechnology Sep 2019

Editorial Board Member of Precision Nanomedicine June 2018

Editorial Board Member of Nature Scientific Reports - Nature Publishers Jan 2018

Academy of NanoGagliato, organising committee Dec-2016

Erasmus Mundus Joint Master Degree "Nanomedicine for Drug Delivery" (NANOMED EMJMD) - associated lecturer Dec 2018

European Commission Expert-advisor for Joint Institute for Innovation Policy (NANODATA project) Dec-2016

NANOFAR associated member for european educational doctorate Sept-2016

Nano World Cancer day - organising committee Dec-2012

European Commission Expert Advisor Task Force Characterization Mar-2016

EuroNanoForum 2013 - International Advisory Group Area Nanomedicine, Healthcare, Nanobiotechnology and Biomaterials Jan-2012

Awards and Honours

Malvern Invited Talk at European NanoMedicine 2017 April 2017

FutureFlash! Best EC Project competition - EuroNanoForum 2015 July 2015

M.Sc. in Translational Oncology - Best new postgraduate course award as lecturer April 2014

EuroNanoForum 2013, Poster prize June 2013

Best Toxicology Paper 2012 - Society of Toxicology March 2012

International Academy of Nanomedicine - Second World Congress of Nanomedicine October 2010

Bioelectromagnetics Society and European Bioelectromagnetics Association award 2005

IEI/Medtronic Bioengineering Award Medal 2003

Calgary Award at the World Congress of Biomechanics, Calgary (Canada) 2002

Student award, 5th International Conference on Cellular Engineering, Aachen (Germany) 2001

Memberships

Member of the BioNanoNet, the Austrian research network in the fields of nanotoxicology, sensor technologies and health and safety including (nano-)medicine. 2018 – to date

Member of European Technology Platform (ETP) in Nanomedicine 2009 – to date

Chair of the Toxicology and Characterisation working group at the European Technology Platform in Nanomedicine (ETPN) 2012 – 2019

Vice-chairman of Nanodiagnostic Working Group - European Technology Platform in Nanomedicine 2009 – 2012

Member of the European Society of Molecular Imaging 2011 – 2015

Member of the Institution of Engineers of Ireland 1998 – 2008

Member of the European Society of Biomechanics 2004 – 2010

Member of the European Bioelectromagnetics Association 2004 – 2008

Membro dell'ordine degli Ingegneri Italiani 1998 – 2000

Member of the Bioelectromagnetics Society 2005 – 2006