Cancer research is a Trinity priority research theme, based on the quality of research which has been generated by its academics. The theme has developed an integrated, thematic programme which involves research across a number of areas including basic science, translation medicine, health economics and planning, and global health.
Trinity researchers working in partnership with clinicians in the teaching hospitals St. James's, Tallaght, The National Paediatric Hospital and The Coombe Women and Infants University Hospital are making advances in both basic and translational research, improving the treatment, and management of cancer in a way that allows people to live good quality lives.
At present there are over 180 scientists actively working on cancer projects as part of a vibrant interdisciplinary research community. They have a track record of high quality cancer research, greatly strengthened by Trinity as an acknowledged international leader in research in biochemistry, immunology, genetics and neurosciences.
Trinity's cancer research covers the full value chain, ranging from new scientific discoveries to the translation of these discoveries into new treatments. Trinity and its affiliated institutions deliver cancer services from cradle to grave with research and treatment of all cancers that occur in children, adolescents, young and older adults. Trinity researchers participate in international cancer research consortia at the highest level.
The Trinity St. James's Cancer Institute aims to educate and to expand knowledge and understanding for best practice with regards to cancer research, as well as develop new treatments and strategies through a combination of biomedical and biomolecular research. The main cancer research niche areas include: lung, ovary, cervix , oesophagus, breast, prostate, colon, salivary, thyroid/head and neck, multiple myeloma, leukaemia, paediatric cancer, cancer stem cell biology, cancer immunology and immunotherapy approaches, radiobiology, chemobiology, tumour microenvironment, cancer imaging, cancer pharmacodynamics and therapeutics, drug modelling and nanomedicine.
Featured Publications & Research Outputs
- Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles.
- MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells.
- Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma.
Research Institutes / Centres
Research at the Trinity St. James's Cancer Institute is an integrated, thematic programme which involves a number of areas including basic science, translation medicine, health economics and planning, and global health. Our aims are to educate and to expand knowledge for best practice with regards to cancer research, as well as develop new treatments and strategies through a combination of biomedical and biomolecular research. Eight research programmes (lung, gastrointestinal, breast, prostate, thyroid/head and neck, haematological malignancies, gynaecological malignancies and skin cancer) have a designated clinical and scientific lead to organise and drive research for this area. Underlying these are translational research themes (cancer biology, cancer genomics, diagnostics, tumour immunology and immunotherapy, therapeutics and drug discovery, cancer prevention, lifestyle/obesity, survivorship and health economics), which provide the structure for multidisciplinary research projects with researchers from Trinity Biomedical Sciences Institute, Smurfit Institute for Genetics, CRANN and Trinity Translational Medicine Institute.
The Institute provides extensive education programmes in Translational Oncology for undergraduate and postgraduate students, scientists, clinicians, nurses and other healthcare professionals. Education programmes are also designed to engage with public-patient involvement (PPI activities). The Institute offers scholarships and fellowship opportunities in clinical and translational research and directs a career development programme for young investigators. ‘Training and educating tomorrow's leaders today’.
Trinity College Dublin and St. James's Hospital are embarking on a journey to develop, on the St. James's hospital campus, a comprehensive cancer centres similar to best international exemplar models to deliver patient-centred care. The first of its kind in Ireland, the Trinity St. James's Cancer Institute sets a new standard for cancer care nationally, integrating medicine and science in cancer prevention, treatment and survivorship. St. James's Hospital and Trinity have been scaling up for the new Cancer Institute with the recruitment of key new clinical academic and research appointments in oncology. It has also became a member of the Organisation of European Cancer Institutes (OECI) that sets the gold standard for leading cancer institutes in Europe. The Trinity St. James's Cancer Institute is currently undergoing a formal OECI accreditation process that will take some time to complete. The accreditation will benchmark performance against international standards and direct the cancer services and research to the next level.
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Featured Trinity Researchers
- Theme Champion and main contact
- Professor of Pathology
- School of Medicine
- Professor of Surgery
- School of Medicine
- Director of the Trinity Translational Medicine Institute (TTMI)
- Professor in Molecular Pathology, School of Medicine
- Professor of Pharmacology
- School of Pharmacy & Pharmaceutical Sciences
- Smurfit Chair of Medical Genetics
- Smurfit Institute of Genetics
- Chair of Organic Chemistry
- School of Chemistry
- Professor of Comparative Immunology
- Trinity Biomedical Sciences Institute
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