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Selected Publications

McGuirk, P. McCann, Mills, K.H.G. (2002) Pathogen-specific T regulatory 1 (Tr1) cells induced in the respiratory tract by a bacterial molecule that stimulates IL-10 production by dendritic cells: a novel strategy for evasion of protective Th1 responses against Bordetella pertussis. J. Exp. Med. 195,221-231.

MacDonald, A.J., Duffy, M., Brady, M.T., McKiernan, S., Hall, W., Hegarty, J., Curry, M., Mills, K.H.G. (2002) CD4+ T helper type 1 and T regulatory type 1 cells induced against the same epitopes on the core protein in hepatitis C virus-infected individuals. J. Infect. Dis. 185, 720-727.

McGuirk P., Mills, K.H.G. (2002) Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23, 450-455.

Lavelle, E., McNeela, E., Armstrong, M., Leavy, O., Higgins, S.C., Mills K.H.G. (2003) Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation. J. Immunol. 171, 2384-2392.

Higgins, S., Lavelle, E., McCann, C., Keogh, B., McNeela, E, Byrne, P., O'Gorman, B., Jarnicki, A., McGuirk, P., Mills, K.H.G. (2003) Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology. J. Immunol. 171, 3119-3127.

Mills, K.H.G, McGuirk, P. (2004). Antigen-specific regulatory T cells – their induction and role in infection. Seminars in Immunology 16 (2), 107-117.

Mills, K.H.G. (2004) Regulatory T cells: friend or foe in immunity to infection. Nature Rev. Immunol. 4, 841-55.

Boyd, A.P., Ross, P.J., Conroy, H., Mahon, N Lavelle, E.C., Mills, K.H.G (2005) Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death. J. Immunol. 175: 730-738.

Loscher, CL Leavy, O. Kelleher, D, Mills, K.H.G, Roche, H.M. (2005) Conjugated linoleic acid suppresses NFkB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction. J. Immunol 175:4990-4998.

Jarnicki, A.G., Lysaght, J, Todryk, S, Mills, K.H.G (2006) Suppression of antitumor immunity by IL-10 and TGF-b-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells. J Immunol 177 (2): 896-904.

Sutton, C, Keogh, B., Brereton, C., Mills, K.H.G¶, Lavelle, E.C¶. (2006) A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 203(7):1685-91. (¶equal contribution).

Higgins, S., Jarnicki, A, Lavelle, E.C., Mills, K.H.G (2006) TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J. Immunol. 177:7980-7989.

Braat, H, McQuirk, P., Ten Kate F.J.W., Huibregtse, I., Dunne, P, Hommes, D.W., Deventer, S, Mills, K.H.G (2006) Prevention of experimental colitis by parenteral administration of a pathogen derived immunomodulatory molecule. Gut 56, 351-357.

Conroy, H. Marshall, N.A., Mills, K.H.G (2008) TLR ligand suppression or enhancement of Treg cells – A double edged sword in immunity to tumors. Oncogene 27(2):168-80.

Jarnicki, AJ, Conroy, H. Brereton, C, , Donnelly, G., Toomey, D., Walsh, K., Sweeney, C., Leavy, O.,  Fletcher, J., Lavelle, E., Dunne, P., Mills, K.H.G (2008) Attenuating regulatory T cell induction by TLR agonists through inhibition of  p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics. J. Immunol 180(6):3797-806. 

Rowan, A.G., Fletcher, J, Ryan, E.J. Moran, B. Hegarty, J. E., O’Farrelly, C., Mills, K.H.G (2008) Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-b. J. Immunol 181(7):4485-94.

Mills, K.H.G (2008) Induction, function and regulation of IL-17-producing T cells. Eur J. Immunol. 38, 2636-2649.

Mills, K.H.G (2008) TLR9 turns the tide on Treg cells. Immunity 29, 518-520.

Rowan, A.G., Fletcher, J, Ryan, E.J. Moran, B. Hegarty, J. E., O'Farrelly, C., Mills, K.H.G (2008) Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-b. J. Immunol 181(7):4485-94.

Dunne, P.J., Moran, B., Cummins, R.C., Mills, K.H.G. (2009) CD11c+CD8a+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. J. Immunol 183, 400-410.

Brereton, C.F., Sutton, C.E., Lavelle, E. C., Mills, K.H.G. (2009) Inhibition of ERK MAP kinase suppresses IL-1b and IL-23-driven IL-17 production and attenuates autoimmune disease. J. Immunol 183(3):1715-23.

Walsh, K., Brady, M.T, Finlay, C., Boon, L., Mills, K.H.G. (2009). Infection with a helminth parasite attenuates autoimmunity through TGF-b mediated suppression of Th17 and Th1 responses. J. Immunol 183(3):1577-86.

Sutton, CE. Lalor, SJ, Sweeney, C, Brereton, C, Lavelle, E.C., Mills, K.H.G  (2009) IL-1b and IL-23 promote innate IL-17 production by gd T cells which amplifies Th17 responses and autoimmunity.  Immunity 31(2):331-41.

Fletcher, J.M., Lonergan, R., Costelloe,L., Kinsella, K. Moran, B. T, O' Farrrelly, C. Tubridy, N., Mills, K.H.G. (2009) CD39+Foxp3+ regulatory T cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis. J. Immunol. 183(11):7602-7610.

Mills, K.H.G., Dunne, A. (2009) IL-1, master mediator or initiator of inflammation. Nature Medicine, 15(12):1363-4.  

Dunne, A., Ross, P.J.  Pospisilova, E., Masin, J, Meaney, A., Sutton, C.E., Tschopp, J. Sebo, P., Mills, K.H.G (2010) Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. J. Immunol 185(3):1711-9.

Masters, S.L., Mielke, L.A. Cornish, A.L., Sutton, C.E., Cengia, L., Roberts, A.W., Wicks, I.P. Mills, K.H.G., Croker, B.A. (2010) IFN-γ promotes IL-1b production from human cells but inhibits IL-1b and IL-17 production from mouse cells. EMBO Rep. 11(8):640-6.

Masters, S.L., Dunne, A., Subrahmanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L.A., Harris, J., Coll, R., Mills, K.H.G., Mok, K.H., Newsholme, P., Nunez, G., Yodoi, J., Kahn, S.E., Lavelle E.C., O'Neill, L.A.J. (2010). Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes. Nature Immunology 11(10):897-904.

Dunne, A. Marshall, A., Mills, K.H.G. (2011) TLRs as therapeutics. Current Opinion in Pharmacology 2011. 11(4):404-11.

Lalor, SJ, Dungan, L Sutton, C.E., Basdeo, S.A. Fletcher, J.M., Mills, K.H.G. (2011). Caspase-1 processed cytokines IL-1b and IL-18 promote IL-17-production by γδ and CD4 T cells that mediate autoimmunity. J. Immunol 186 (10), 5738-5748.  

Brereton, C.F.,  Sutton, C.E., Ross, P.J. Iwakura, Y. Pizza, M. Rappuoli, R. Lavelle, E.C., Mills, K.H.G. (2011). Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection via activation of IL-1 and IL-23. J. Immunol 186 (10) 5896 -5906.

Mills, K.H.G. (2011) TLR-dependant T cell activation in autoimmunity. Nature Rev. Immunol. 11(12): 807-22.

Byrne, W.L., Mills, K.H.G., Lederer, J.A., O'Sullivan, G.A. (2011) Targeting Regulatory T Cells in Cancer. Cancer Research; 71(22): 6915-20.

Marshall, N.A., Galvin, K.C., Corcoran, A-M.B., Boon, L., Higgs, R., Mills, K.H.G (2012). Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T-cells that mediate rejection of murine tumors. Cancer Research 72(3):581-91.

Allen, A. C., S. Kelly, S. A. Basdeo, K. Kinsella, K. J. Mulready, K. H. Mills, N. Tubridy, C. Walsh, J. J. Brady, M. Hutchinson, and J. M. Fletcher. 2012. A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers. Mult Scler. 18(12):1797-800.

Coleman, M. M., C. M. Finlay, B. Moran, J. Keane, P. J. Dunne, and K. H. Mills. 2012. The immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis. FEMS Immunol Med Microbiol 64: 413-424.

Conroy, H., K. C. Galvin, S. C. Higgins, and K. H. Mills. 2012. Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells. Cancer Immunol Immunother 61: 425-431.

Cunningham, C. C., E. Mills, L. A. Mielke, L. K. O'Farrell, E. Lavelle, A. Mori, G. M. McCarthy, K. H. Mills, and A. Dunne. 2012. Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase. Clin Immunol 144: 228-236.

Higgs, R., S. C. Higgins, P. J. Ross, and K. H. Mills. 2012. Immunity to the respiratory pathogen Bordetella pertussis. Mucosal Immunol 5: 485-500.

Jones, S. A., C. E. Sutton, D. Cua, and K. H. Mills. 2012. Therapeutic potential of targeting IL-17. Nat Immunol 13: 1022-1025.

Peral de Castro, C., S. A. Jones, C. Ni Cheallaigh, C. A. Hearnden, L. Williams, J. Winter, E. C. Lavelle, K. H. Mills, and J. Harris. 2012. Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion. J Immunol 189: 4144-4153.

Reynolds, C. M., F. C. McGillicuddy, K. A. Harford, O. M. Finucane, K. H. Mills, and H. M. Roche. 2012. Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance. Molecular nutrition & food research 56: 1212-1222.

Sutton, C. E., L. A. Mielke, and K. H. Mills. 2012. IL-17-producing gammadelta T cells and innate lymphoid cells. Eur J Immunol 42: 2221-2231.

Pindjakova, J., Hanley, S. A., Duffy, M. M., Sutton, C. E., Weidhofer, G. A., Miller, M. N., Nath, K. A., Mills, K. H., Ceredig, R. and Griffin, M. D., 2012. Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction. Kidney Int. 81: 379-390.

Mills, K. H., Dungan, L. S., Jones, S. A. and Harris, J., 2012. The role of inflammasome-derived IL-1 in driving IL-17 responses. J Leukoc Biol 2012.

Coleman, M. M., D. Ruane, B. Moran, P. J. Dunne, J. Keane, and K. H. Mills. 2013. Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells. Am J Respir Cell Mol Biol

Browne, T. C., K. McQuillan, R. M. McManus, J. A. O'Reilly, K. H. Mills, and M. A. Lynch. 2013. IFN-gamma Production by amyloid beta-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. J Immunol 190: 2241-2251.

Jones, S. A., K. H. Mills, and J. Harris. 2013. Autophagy and inflammatory diseases. Immunol Cell Biol 91: 250-258.

Mills, K. H., L. S. Dungan, S. A. Jones, and J. Harris. 2013. The role of inflammasome-derived IL-1 in driving IL-17 responses. J Leukoc Biol 93: 489-497.

Ross, P. J., C. E. Sutton, S. Higgins, A. C. Allen, K. Walsh, A. Misiak, E. C. Lavelle, R. M. McLoughlin, and K. H. Mills. 2013. Relative contribution of Th1 and Th17 cells in adaptive immunity to Bordetella pertussis: towards the rational design of an improved acellular pertussis vaccine. PLoS Pathog 9: e1003264

Morine, M. J., S. Toomey, F. C. McGillicuddy, C. M. Reynolds, K. A. Power, J. A. Browne, C. Loscher, K. H. Mills, and H. M. Roche. 2013. Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice. J Nutr Biochem 24: 788-795.

Galvin, K. C., L. Dyck, N. A. Marshall, A. M. Stefanska, K. P. Walsh, B. Moran, S. C. Higgins, L. S. Dungan, and K. H. Mills. 2013. Blocking retinoic acid receptor-alpha enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells. Cancer Immunol Immunother. 62(7):1273-82.

Walsh, K. P., and K. H. Mills. 2013. Dendritic cells and other innate determinants of T helper cell polarisation. Trends Immunol 34: 521-530.

McGillicuddy, F. C., C. M. Reynolds, O. Finucane, E. Coleman, K. A. Harford, C. Grant, D. Sergi, L. M. Williams, K. H. Mills, and H. M. Roche. 2013. Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice. Am J Physiol Endocrinol Metab. 305(7): E834-44.

Mielke, L. A., S. A. Jones, M. Raverdeau, R. Higgs, A. Stefanska, J. R. Groom, A. Misiak, L. S. Dungan, C. E. Sutton, G. Streubel, A. P. Bracken, and K. H. Mills. 2013. Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med 210: 1117-1124.

Adkins, I., J. Kamanova, A. Kocourkova, M. Svedova, J. Tomala, H. Janova, J. Masin, B. Chladkova, L. Bumba, M. Kovar, P. J. Ross, L. Tuckova, R. Spisek, K. H. Mills, and P. Sebo. 2014. Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells. PLoS One 9: e104064.

Allen, A. C., and K. H. Mills. 2014. Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity. Expert Rev Vaccines 13: 1253-1264.

Butt, A. Q., and K. H. Mills. 2014. Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines. Oncogene 33: 4623-4631.

Draper, E., J. DeCourcey, S. C. Higgins, M. Canavan, F. McEvoy, M. Lynch, B. Keogh, C. Reynolds, H. M. Roche, K. H. Mills, and C. E. Loscher. 2014. Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses. J Nutr Biochem 25: 741-749.

Dungan, L. S., N. C. McGuinness, L. Boon, M. A. Lynch, and K. H. Mills. 2014. Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages. Eur J Immunol 44: 2903-2917.

Finlay, C. M., K. P. Walsh, and K. H. Mills. 2014. Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases. Immunol Rev 259: 206-230.

McManus, R. M., S. C. Higgins, K. H. Mills, and M. A. Lynch. 2014. Respiratory infection promotes T cell infiltration and amyloid-beta deposition in APP/PS1 mice. Neurobiol Aging 35: 109-121.

Mills, K. H. 2014. Prior exposure to bacteria attenuates viral disease of the respiratory tract: a role for IL-17 and innate immune memory? Am J Respir Crit Care Med 189: 126-128.

Mills, K. H., and V. Gerdts. 2014. Mouse and pig models for studies of natural and vaccine-induced immunity to Bordetella pertussis. J Infect Dis 209 Suppl 1: S16-19.

Mills, K. H., P. J. Ross, A. C. Allen, and M. M. Wilk. 2014. Do we need a new vaccine to control the re-emergence of pertussis? Trends Microbiol 22: 49-52.

Murphy, A. G., K. M. O'Keeffe, S. J. Lalor, B. M. Maher, K. H. Mills, and R. M. McLoughlin. 2014. Staphylococcus aureus infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol 192: 3697-3708.

Raverdeau, M., and K. H. Mills. 2014. Modulation of T cell and innate immune responses by retinoic Acid. J Immunol 192: 2953-2958.

Aleman, M. M., M. J. Kesic, K. H. Mills, D. B. Peden, and M. L. Hernandez. 2015. The IL-1 axis is associated with airway inflammation after O3 exposure in allergic asthmatic patients. J Allergy Clin Immunol 136: 1099-1101.e1092.

Basdeo, S. A., B. Moran, D. Cluxton, M. Canavan, J. McCormick, M. Connolly, C. Orr, K. H. Mills, D. J. Veale, U. Fearon, and J. M. Fletcher. 2015. Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity. J Immunol 195: 528-540.

Bernard, N. J., C. M. Finlay, G. M. Tannahill, J. P. Cassidy, L. A. O'Neill, and K. H. Mills. 2015. A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis. Mucosal Immunol 8: 982-992.

Brummelman, J., M. M. Wilk, W. G. Han, C. A. van Els, and K. H. Mills. 2015. Roads to the development of improved pertussis vaccines paved by immunology. Pathogens and disease 73: ftv067.

Coll, R. C., A. A. Robertson, J. J. Chae, S. C. Higgins, R. Munoz-Planillo, M. C. Inserra, I. Vetter, L. S. Dungan, B. G. Monks, A. Stutz, D. E. Croker, M. S. Butler, M. Haneklaus, C. E. Sutton, G. Nunez, E. Latz, D. L. Kastner, K. H. Mills, S. L. Masters, K. Schroder, M. A. Cooper, and L. A. O'Neill. 2015. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med 21: 248-255.

Dunne, A., L. A. Mielke, A. C. Allen, C. E. Sutton, R. Higgs, C. C. Cunningham, S. C. Higgins, and K. H. Mills. 2015. A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunol 8: 607-617.

Edwards, S. C., S. C. Higgins, and K. H. G. Mills. 2015. Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction. Brain Behav Immun 50: 41-46.

Edwards, S. C., A. M. McGinley, N. C. McGuinness, and K. H. Mills. 2015. gammadelta T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity. Frontiers in immunology 6: 455.

Flood, B., K. Oficjalska, D. Laukens, J. Fay, A. O'Grady, F. Caiazza, Z. Heetun, K. H. Mills, K. Sheahan, E. J. Ryan, G. A. Doherty, E. Kay, and E. M. Creagh. 2015. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clin Exp Immunol 181: 39-50.

McManus, R. M., K. H. Mills, and M. A. Lynch. 2015. T Cells-Protective or Pathogenic in Alzheimer's Disease? Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology 10: 547-560.

Murphy, A. G., K. M. O'Keeffe, S. J. Lalor, B. M. Maher, K. H. Mills, and R. M. McLoughlin. 2015. Correction: Staphylococcus aureus Infection of mice expands a population of memory gammadelta T cells that are protective against subsequent infection. J Immunol 194: 4588.

Netea, M. G., E. Latz, K. H. Mills, and L. A. O'Neill. 2015. Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol 16: 675-679.

Oficjalska, K., M. Raverdeau, G. Aviello, S. C. Wade, A. Hickey, K. M. Sheehan, S. C. Corr, E. W. Kay, L. A. O'Neill, K. H. Mills, and E. M. Creagh. 2015. Protective role for caspase-11 during acute experimental murine colitis. J Immunol 194: 1252-1260.

Dyck, L., M. M. Wilk, M. Raverdeau, A. Misiak, L. Boon, and K. H. Mills. 2016. Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model. Cancer Immunol Immunother 65: 1491-1498.

Exley, M. A., G. C. Tsokos, K. H. Mills, D. Elewaut, and B. Mulhearn. 2016. What rheumatologists need to know about innate lymphocytes. Nat Rev Rheumatol 12: 658-668.

Finlay, C. M., A. M. Stefanska, K. P. Walsh, P. J. Kelly, L. Boon, E. C. Lavelle, P. T. Walsh, and K. H. Mills. 2016. Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia. J Immunol 196: 703-714.

Gardiner, C. M., and K. H. Mills. 2016. The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases. Semin Immunol 28: 343-350.

Lee, J. P., A. Foote, H. Fan, C. Peral de Castro, T. Lang, S. A. Jones, N. Gavrilescu, K. H. Mills, M. Leech, E. F. Morand, and J. Harris. 2016. Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages. Autophagy 12: 907-916.

Mulcahy, M. E., J. M. Leech, J. C. Renauld, K. H. Mills, and R. M. McLoughlin. 2016. Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa. Mucosal Immunol 9: 1429-1441.

Netea, M. G., L. A. Joosten, E. Latz, K. H. Mills, G. Natoli, H. G. Stunnenberg, L. A. O'Neill, and R. J. Xavier. 2016. Trained immunity: A program of innate immune memory in health and disease. Science 352: aaf1098.

Raverdeau, M., C. J. Breen, A. Misiak, and K. H. Mills. 2016. Retinoic acid suppresses IL-17 production and pathogenic activity of gammadelta T cells in CNS autoimmunity. Immunol Cell Biol 94: 763-773.

Saadatian-Elahi, M., S. Plotkin, K. H. Mills, S. A. Halperin, P. B. McIntyre, V. Picot, J. Louis, and D. R. Johnson. 2016. Pertussis: Biology, epidemiology and prevention. Vaccine 34: 5819-5826.

Dyck, L., and K. H. G. Mills. 2017. Immune checkpoints and their inhibition in cancer and infectious diseases. Eur J Immunol 47: 765-779.

Gu, X. X., S. A. Plotkin, K. M. Edwards, A. Sette, K. H. G. Mills, O. Levy, A. J. Sant, A. Mo, W. Alexander, K. T. Lu, and C. E. Taylor. 2017. Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases. Clin Vaccine Immunol 24.

McManus, R. M., O. M. Finucane, M. M. Wilk, K. H. G. Mills, and M. A. Lynch. 2017. FTY720 Attenuates Infection-Induced Enhancement of Abeta Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology.

Misiak, A., M. M. Wilk, M. Raverdeau, and K. H. Mills. 2017. IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory gammadelta T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice. J Immunol 198: 363-374.

Nascimento, I. P., D. Rodriguez, C. C. Santos, E. P. Amaral, H. K. Rofatto, A. P. Junqueira-Kipnis, E. D. C. Goncalves, M. R. D'Imperio-Lima, M. H. Hirata, C. L. Silva, N. Winter, B. Gicquel, K. H. G. Mills, M. Pizza, R. Rappuoli, and L. C. C. Leite. 2017. Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis. Scientific reports 7: 2109.

Netea, M. G., F. Balkwill, M. Chonchol, F. Cominelli, M. Y. Donath, E. J. Giamarellos-Bourboulis, D. Golenbock, M. S. Gresnigt, M. T. Heneka, H. M. Hoffman, R. Hotchkiss, L. A. B. Joosten, D. L. Kastner, M. Korte, E. Latz, P. Libby, T. Mandrup-Poulsen, A. Mantovani, K. H. G. Mills, K. L. Nowak, L. A. O'Neill, P. Pickkers, T. van der Poll, P. M. Ridker, J. Schalkwijk, D. A. Schwartz, B. Siegmund, C. J. Steer, H. Tilg, J. W. M. van der Meer, F. L. van de Veerdonk, and C. A. Dinarello. 2017. A guiding map for inflammation. Nat Immunol 18: 826-831.

Varghese, S., M. Cotter, F. Chevot, C. Fergus, C. Cunningham, K. H. Mills, S. J. Connon, J. M. Southern, and V. P. Kelly. 2017. In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis. Nucleic Acids Res 45: 2029-2039.

Wilk, M. M., A. Misiak, R. M. McManus, A. C. Allen, M. A. Lynch, and K. H. G. Mills. 2017. Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis. J Immunol 199: 233-243.

Finlay, C. M., A. M. Stefanska, M. M. Coleman, H. Jahns, J. P. Cassidy, R. M. McLoughlin, and K. H. G. Mills. 2017. Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy. Parasite Immunol 39.

Misiak, A., R. Leuzzi, A. C. Allen, B. Galletti, B. C. Baudner, U. D'Oro, D. T. O'Hagan, M. Pizza, A. Seubert, and K. H. G. Mills. 2017. Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model. Vaccine 35: 5256-5263.

Palsson-McDermott, E. M., L. Dyck, Z. Zaslona, D. Menon, A. F. McGettrick, K. H. G. Mills, and L. A. O'Neill. 2017. Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors. Frontiers in Immunology 8: 1300.

C.E. Sutton, C.M. Finlay, M. Raverdeau, J.O. Early, J. deCourcey, Z. Zaslona, L.A.J. O'Neill, K.H.G. Mills* and A.M. Curtis*. 2017. Loss of the molecular clock in myeloid cells exacerbates T cell-mediated autoimmune disease. Nature Comm Dec 12 2017, 8(1):1923. *Equal contribution

McGinley, A., S.C. Edwards, M. Raverdeau and K.H.G. Mills. 2018. Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis. J. Autoimmunity 2018 Jan 21 pii S0896-8411(18)30007-6.

Fuchs, A., M. Gliwinski, --- K. H. G. Mills, ---- P. Trzonkowski et al. 2018. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Frontiers in Immunology 8: 1844.

Cossarizza, ---- K. H. G. Mills, ---- J. Zimmermann et al. 2018. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol 47: 1584-1797