Selected Publications
- Lacey, K.A., Geoghegan, J.A., McLoughlin, R.M. Cell wall-anchored proteins: their role in Staphylococcus aureus Skin Infections and potential as vaccine antigens. Pathogens 2016 in press
- Mulcahy, ME., Leech, JM., Renauld, JC., Mills, KHG., McLoughlin, RM. Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa. Mucosal Immunology Jan 2016 in press
- Brown, A.F., Murphy, A.G., Lalor, S.J., Leech, J.M., O’Keeffe, K.M., Mac Aogain, M., O’Halloran, D.P., Lacey, K.A., Tavakol, M., Hearnden, C.H., Fitzgerald-Hugher, D., Humphreys, H., Fennell, J.P., van Wamel, W.J., Foster, T.J., Geoghegan, J.A., Lavelle, E.C., Rogers, T.R., McLoughlin, R.M. Memory Th1 cells are protective in invasive Staphylococcus aureus infection. PlosPathogen 2015 Nov 5;11(11)e1005226
- O’Keeffe, K.M.,Wilk, M.M., Leech, J.M., Murphy, A.G., Laabei, M., Monk, I.R., Massey, R.C., Lindsay, J.A., Foster, T.J., Geoghegan, J.A., McLoughlin, R.M. Manipulation of autophagy in phagocytes facilitates Staphylococcus aureus bloodstream infection. Infect Immun 2015 Sep;83(9):3445-57
- Stack, M., Doyle, L.S., Connolly, J.L., Reinert, S.L., O’Keeffe, K.M., McLoughlin, R.M.,Paludan,S.R., Bowie, A.G. TRAM is required for TLR2 endosomal signaling to type I IFN induction. J Immunol 2014 Dec 15;193(12):6090-102
- Maher, BM, Mulcahy, ME., Murphy, AG., Wilk, M., O'Keeffe, KM., Geoghegan, JA., Lavelle, EC., McLoughlin, RM. Nlrp-3 driven IL-17 production by gdT-cells controls infection outcomes during Staphylococcus aureus surgical site infection. Infect Immun 2013 Dec;81(12):4478-89
- Misstear, K., McNeela, EA., Murphy, AG., Geoghegan, JA., O'Keeffe, KM., Fox, J., Chan, K., Heuking, S., Collin, N., Foster, TJ., McLoughlin, RM†., Lavelle, EC†. Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus. J Infect Dis 2014 May 1;209(9):1479-84 (†Equal contribution)
- Brown AF, Leech JM, Rogers TR, McLoughlin RM. Staphylococcus aureus Colonization: Modulation of Host Immune Response and Impact on Human Vaccine Design. Front Immunol. 2014 Jan 8;4:507.
- Fielding, C.A., Jones, G.W., McLoughlin, R.M., McLeod, L., Williams, A.S., Lambie, M., Foster, L.T., Liao, C.T., Hammond, V.J., Rice, C.M., Greenhill, C.J., Colmont, C.S., Ham, E., Coles, B., Kift-Morgan, A., Newton, Z., Craig, K.J., Williams, J.D., Williams, G.T., Davies, S.J., O'Donnell, V.B., Taylor, P.R., Jenkins, B.J., Topley, N., Jones, S.A. IL-6 Signaling Drives Fibrosis in Unresolved Inflammation. Immunity 2014 Jan 16;40(1):40-50
- Murphy A.G., O'Keeffe, K.M., Lalor, S.J., Maher B.M., Mills K.H.G., McLoughlin R.M. Staphylococcus aureus infection of mice expands a population of memory γδ T cells that are protective against subsequent infection. J Immunol 2014 Apr 15;192(8):3697-708
- Mulcahy, M.E., Geoghegan, J.A., Monk, I.R., O'Keeffe, K.M., Walsh, E.J., Foster, T.J., McLoughlin R.M. Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin. PLoS Pathogen Dec;8(12):e1003092.
- Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH. Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine. PLoS Pathog. 2013 Apr;9(4):e1003264. Epub 2013 Apr 4.
- McLoughlin RM., Calatroni, A., Visnes, CM., Ly, NP., Wallace, PK., Cruikshank, WW., O'Connor, GT., Gern, JE, Gold, DR. Longitudinal Relationship of Early-Life Immunomodulatory T-cell Phenotype and Function to Development of Allergic Sensitization in an Urban Cohort. Clin Exp Allergy 2011 Nov 9.
- Chi A, Wildfire J, McLoughlin R, Wood RA, Bloomberg GR, Kattan M, Gergen P, Gold DR, Witter F, Chen T, Holick M, Visness C, Gern J, O'Connor GT. Umbilical cord plasma 25-hydroxyvitamin D concentration and immune function at birth: the Urban Environment and Childhood Asthma study. Clin Exp Allergy. 2011 Jun;41(6):842-50.
- Cohen- Poradosu, R., McLoughlin, R.M., Lee, J.C., Kasper, D.L. Bacteroides fragilis – stimulated IL-10 contains expanding infection. Submitted J Infect DIs 2011 204(3):363-71
- McLoughlin, RM., Mills, K.H.G. Influence of gastrointestinal commensal bacteria on the cellular immune responses that mediate allergy and asthma. J Allergy Clin Invest 2011 127(5):1097-107
- McLoughlin, RM., Topley, N. Switching on EMT in the peritoneal membrane: considering the evidence. Nephrol Dial Transplant 2011 Jan;26(1):12-5.
- McNeela, E.A., Burke, A., Neill, D.R., Baxter, C., Fernandes, V.E., Ferreira, D., Smeaton, S., El-Rachkidy, R., Mcloughlin, RM., Mori, A., Moran, B., Fitzgerald, K.A., Tschopp, J., Petrilli, V., Andrew, P.W., Kadioglu, A., Lavelle, E.C. Pneumolysin activates the NALP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog 2010 6(11): e1001191
- Weidenmaier, C., McLoughlin, RM., Lee, J.C. The zwitterionic cell-wall teichoic acid of Staphylococcus aureus provokes skin abscesses in mice by a novel CD4+ T-cell–dependent mechanism. Plos One 2010 5(10):e13227
- Lee, J.C., Greenwich, J.L., Zhanel, G., Han, X., Saward, L., McLoughlin, RM. Modulation of the local neutrophil response by a novel Hyaluronic acid binding peptide reduces bacterial burden during staphylococcal wound infection. Infection & Immunity 2010 78(10):4176-86.
- Jones, G.W., McLoughlin, RM., Hammond, J.V., Parker, C.R., Williams, J.D., Malhotra, R., Scheller, J., Williams, A.S., Topley, N., Jones, S.A. Loss of CD4+ T cell IL-6R expression during local inflammation underlies a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol 2010 184:2130-2139
- Ni, J,. McLoughlin, RM ., Brodovitch, A., Moulin, P., Brouckaert, P., Casadei, B., Feron, O., Topley, N., Balligand, J.L., Devuyst, O. Nitric Oxide synthase isoforms play distinct roles during acute peritonitis. Nephrol Dial Transplant 2010; 25 (1):86-96.
- Ngoc P Ly, N.P., Ruiz-Perez, B., McLoughlin, RM., Visness, C., Wallace, P., Cruikshank, W., Tzianabos, A., O'Connor, G., Gold D.R., Gern. J. Characterization of Regulatory T cells in Urban Newborns. Clin Mol Allergy 2009 Jul 8;7:8.
- McLoughlin, RM, Lee, JC, Kasper, DL and Tzianabos, AO. IFN-g regulated chemokine production determines the outcome of Staphylococcus aureus infection. J Immunol 2008; 181 (2): 1323-1332
- Fielding, CA*, McLoughlin, RM* , McLeod. L, Colmont, CS, Najdovska, M, Grail, D, Ernst, M, Jones, SA, Topley, N and Jenkins, BJ. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. J Immunol 2008; 181(3): 2189-2195 (*equal contribution).
- Wang, Q, McLoughlin RM , Cobb, BA, Charrel-Dennis, M, Zaleski, KJ, Golenblock, D, Tzianabos, AO, Kasper, DL. A Bacterial Carbohydrate Links Innate and Adaptive Responses through Toll-Like Receptor 2. J Exp Med 2006 Dec 25;203(13):2853-63.
- Zaleski KJ, Kolodka T, Cywes-Bentley C, McLoughlin RM, Delaney ML, Charlton BT, Johnson W, Tzianabos AO. Hyaluronic acid binding peptides prevent experimental staphylococcal wound infection. Antimicrob Agents Chemother. 2006;50(11):3856-60.
- McLoughlin RM , Solinga RM, Rich J, Zaleski KJ, Cocchiaro JL, Risley A, Tzianabos AO, Lee JC. CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections. Proc Natl Acad Sci USA. 2006;103 (27):10408-13
- Richards PJ, Nowell MA, Horiuchi S, McLoughlin RM , Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 2006;54 (5):1662-72.
- Fielding CA, McLoughlin RM, Colmont CS, Kovaleva M, Harris DA, Rose-John S, Topley N, Jones SA. Viral IL-6 Blocks Neutrophil Infiltration during Acute Inflammation. J Immunol 2005; 175(6): 4024-9
- McLoughlin RM. Resolving peritoneal inflammation: Flicking the right “switches”. Perit Dial Int 2005; 25:223-229
- Ni J, Cnops Y, McLoughlin RM , Topley N, Devuyst O. Inhibition of nitric oxide synthase reverses permeability changes in a mouse model of acute peritonitis. Perit Dial Int. 2005; Feb 25 Suppl 3:S11
- Mcloughlin R.M, Jenkins BJ, Grail D, Williams AS, Fielding CA, Parker CR, Ernst M, Topley N, Jones SA. IL-6 trans-signaling via STAT3 directs T-cell infiltration in acute inflammation. Proc Natl Acad Sci 2005; 102:9589-94.
- Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, Mcloughlin RM, Jones SA, Topley N, Baumann H, Judd LM, Giraud AS, Boussioutas A, Zhu H.J, Ernst M. Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-b signaling. Nat Med 2005; 11(8):845-52.
- McLoughlin RM , Hurst SM, Nowell MA, Harris DA, Horiuchi S, Morgan LW, Wilkinson TS, Yamamoto, N, Topley N, Jones, SA. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. J Immunol 2004;172: 5676-83
- Mortier S, De Vriese AS, McLoughlin RM , Topley N, Schaub TP, Passlick-Deetjen J, Lameire NH. Effects of conventional and new peritoneal dialysis fluids on leukocyte recruitment in the rat peritoneal membrane. J Am Soc Nephrol 2003; 14: 1296-06
- McLoughlin RM , Witowski J, Robson R, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N. Interplay between IFN-g and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 2003; 112:598-07
- Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM , Giddings JC, Lewis MJ, Haslam RJ, Freeman BA,O'Donnell VB. Nitrolinoleate Inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP. J Biol Chem 2002; 277(8): 5832-40
- Hurst SM, McLoughlin RM , Monslow J, Owens S, Fuller GM, Topley,N, Jones SA. Secretion of Oncostatin M by infiltrating neutrophils: Regulation of IL-6 and chemokine expression in human mesothelial cells. J Immunol 2002;169: 5244-51
- Robson RL, McLoughlin RM , Witowski J, Loetscher P, Wilkinson TS, Jones SA, Topley N. Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-g controls neutrophil migration across the mesothelium in vitro and in vivo. J Immunol 2001; 167 (2): 1028-38
- Hurst S M., Wilkinson TS, McLoughlin R M., Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller G. M, Topley N, Jones SA. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 2001; 14(6): 705-14.
- Davenport A, Li F, Robson R, Wilkinson TS, McLoughlin RM, Topley N. Early Peritoneal Responses to Bacterial Invasion: Cellular Exudation. Sepsis, 1999; 3(4): 303
Book Chapters
Aisling F Brown & Rachel M. McLoughlin. Host pathogen interactions. Staphylococcus: Genetics and Physiology. Caister Academic Press 2016
Alison G. Murphy & Rachel M. McLoughlin. The importance of cell mediated immunity for bacterial vaccines. Vaccine Design: Innovative Approaches and Noel Strategies. Horizon Press. 2015
Rachel M. McLoughlin & Dennis L. Kasper. Immunomodulation by zwitterionic polysaccharides. Microbial Glycobiology: Structure, Relevance and Applications. Elsevier. August 2009.