Selected Publications
Díaz-Payno, P., Cunniffe G.M., Sheehy, E.J., Critchley, S., Almeida, H., Pitacco, P., Carroll, S., Mahon, O., Dunne, A., Levingstone, T., Moran, C., Brady, R., O'Brien, F.J., Brama, P. and Kelly, D.J. Layering of tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues. Biomaterials (2018) 4;188:63-73.
McCarthy, GM & Dunne, A. Calcium Crystal Deposition Diseases. Nature Reviews Rheumatology (2018) 14: 592–602.
Mahon, O. & Dunne, A. Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets. Frontiers in Immunology (2018) 9:1145.
Mahon, O., Cunningham, C.C., Helbert, L., McCarthy, G.M., Kelly, D.J. and Dunne, A. Orthopaedic implant materials drive M1 macrophage polarization in a Spleen Tyrosine Kinase- and Mitogen-Activated Protein Kinase-dependent manner. Acta Biomaterialia (2018) 65:426-435.
Campbell, N., Fitzgerald, H., Malara, A., Hambly, R., Sweeney, C., Kirby, B., Fletcher, J. and Dunne, A. Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment. Scientific Reports(2018) 8:10287
Corr, E.M, Cunningham, C.C., Helbert, L., McCarthy, G.M. and Dunne, A. Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells. Arthritis Res Ther. (2017) 19(1):23.
Cunniffe, G.M., Díaz-Payno, P.J., Ramey, J.S., Mahon, OR, Dunne, A., Thompson, E.M. O’Brien, F.J. and Kelly, D.J. Growth plate extracellular matrix-derived scaffolds for large bone defect healing. eCells and Materials (2017) 33:130-142.
Cunningham, C., Corr, E.M., McCarthy, G.M. and Dunne A. Intra-articular Basic Calcium Phosphate and Monosodium Urate Crystals Inhibit Anti-osteoclastogenic Cytokine Signalling. (2016) Osteoarthritis and Cartilage 24(12):2141-2152.
Corr EM, Cunningham CC, Dunne A. Cholesterol crystals activate Syk and PI3 kinase in human macrophages and dendritic cells. (2016) Atherosclerosis. 251:197-205.
Basdeo, S., Campbell, N., Sullivan, L., Flood, B., Creagh, E., Fletcher, J and Dunne A. Suppression of human alloreactive T cells by linear tetrapyrroles; relevance for transplantation. (2016) Translational Research 178:81-94.
Cunningham, C., Corr, E., Cox, D.C. and Dunne A. Investigating inflammasome activation under conditions of cellular stress or injury. (2015) Methods Mol. Biol. 1292:105-13.
Cox, D.J., Field,R.H., Williams, D.G., Baran, M., Bowie, A.G., Cunningham, C and Dunne, A. Expression and functional analysis of DNA sensors in astrocytes and microglia. (2015) Glia. 63(5):812-25.
Dunne, A., Mielke, L.A., Allen, A., Sutton C.E., Higgs, R., Higgins, S.C, Cunningham, C. and Mills, K.H.G. (2014) A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine. Mucosal Immunology (In Press)
Wochal P, Rathinam VA, Dunne A, Carlson T, Kuang W, Seidl KJ, Hall JP, Lin LL, Collins M, Schattgen SA, MacKay CR, Fagundes CT, Carpenter S, Fitzgerald KA, O'Neill LA. (2014). TRIL is involved in cytokine production in the brain following Escherichia coli infection. J Immunol. 193:1911-9.
Franklin, E, Mantle, T and Dunne A. Activation of human biliverdin-IXa reductase by urea: Generation of kinetically distinct forms during the unfolding pathway. (2013) Biochim Biophys Acta. 1834:2573-2578.
Westwell-Roper, C, Dunne, A, Kim, M.L., Verchere, C.B and Masters, S.L. Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP. (2013) Methods Mol Biol. 1040:9-18.
Cunningham, C., Mills, E., Mielke, L.A., O'Farrell, L.K., Lavelle, E., Mori, A., M. McCarthy, G.M., Mills, K.H and Dunne, A. Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokine production via activation of Syk and PI3 kinase. (2012) Clinical Immunology, 144(3):228-36.
Carpenter S, Wochal P, Dunne A, O'Neill LA. Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with Leucine-rich Repeats (TRIL).(2011) J. Biol. Chem. 286:38795-804.
Dunne, A, Marshall N.M. and Mills, K.H. Targeting Toll-like receptors. Curr. Opin. Pharmacol. (2011) Curr. Opin. Pharmacology 11:404-11
Dunne, A. Inflammasome activation: From inflammatory disease to infection. (2011) Biochem. Soc. Trans. 39(2):669-73.
Masters, S.L., Dunne, A ., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., Mullooly, N., Mielke, L.A., Harris, J., Coll, R.C., Mills, K.H.G., Mok, K.H., Newsholme, P., Nuñez, G., Yodoi, J., Kahn, S.E., Lavelle, E.C. and O'Neill, L.A. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1b in type 2 diabetes. (2010) Nature Immunology. 11:897-904.
Dunne, A ., Ross, P.J., Pospisilova, E., Masin, J., Meaney, A., Sutton, C., Tschopp, J., Sebo, P & Mills, K.H. IL-1b Induction via Toxin-mediated Activation of the Inflammasome Promotes Th17 Responses and Protective Immunity to Bordetella pertussis. (2010) J.Immunol. 185:1711-9.
Dunne, A., Carpenter, S., Gray, P., Constantinos, B, Strelow, A., Wesche, H, Morris, N & O'Neill, L.A. IRAK1 and IRAK4 promote Phosphorylation, Ubiquitination and Degradation of MyD88 Adapter-like (MAL). (2010) J.Biol.Chem. 285:18276-82.
Mills, K.H & Dunne, A. Immune modulation: IL-1, master mediator or initiator of inflammation. (2009) Nature Medicine 15:1363-4.
Carpenter, S, Carlson, T., Garcia, A., Hertzog, PJ., Lyons, A.N., Lynch, M., Monie, T., Seidl, K., O'Neill, L.A. & Dunne, A. Toll-like receptor (TLR) 4 Interactor with Leucine-rich repeats (TRIL), functional component of the TLR4 signaling complex highly expressed in brain. (2009) J. Immunol. 183:3989-95.
Miggin SM, Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA. NF-{kappa}B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. (2007) Proc Natl Acad Sci. 104(9):3372-7.
Khor., C.C., Chapman, S.J., Vannberg, F.O., Dunne, A., Murphy, C., Ling, E.Y., Frodsham, A.J., Walley., A.J., Kyrieleis, O., Khan, A., Aucan, C., Segal, S., Moore, C.E., Knox, K., Campbell, S.J., Lienhardt, C., Scott, A., Asby, P., Sow, O.Y., Grignani, R.Y., Williams, T.N., Davies, R.J., Day, N.P., Crook, D.W., Marsh, K., Berkley, J.A., O'Neill, L.A. and Hill, A.V.S. A functional variant of Mal/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis. (2007) Nature Genetics. 39(4):523-528.
Franklin, E., Browne, S., Hayes, J., Boland, C., Dunne, A., Elliot, G. and Mantle, T.J. Activation of the NADH-dependent activity of biliverdin-IXa reductase (BVR-A) by inorganic phosphate and related anions. (2007) Biochem. J. 405:61-7.
Gray P., Dunne A, Jefferies, C.A., Constantinos, B., Doyle, S., O'Neill, L.A. Mal is a substrate for Bruton's Tyrosine Kinase. (2006) J.Biol.Chem. 281(15):10489-95.
Dunne, A and O'Neill, L.A. New insights into the post-translational modification of Toll-like receptor signaling molecules. (2005) J. Endotoxin. Res. 11(6):325-32.
Dunne, A and O'Neill, L.A. Adaptor usage and Toll-like receptor signaling specificity. (2005) FEBS Lett. 579(15):3330-5.
Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O'Neill LA, Liew FY. (2004). ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. (2004) Nature Immunology; 4:373-9.
Dunne, A and O'Neill, L.A. The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defence. (2003) Sci STKE 171: re3.
Dunne, A., Ejdeback, M.E., Ludidi, P.L., O'Neill, L.A. and Gay, N.J. (2003) Structural complementarity of Toll/Interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. (2003) J. Biol.Chem. 278(42):41443-51
O'Neill LA, Dunne A, Ejdeback M, Gray P, Jefferies C, Wietek C. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. (2003) J.Endotoxin Res. 9, 55-9.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA. Bruton's tyrosine kinase is a TIR domain binding protein that participates in Nfkappa B activation by Toll-like receptor 4. (2003) J. Biol. Chem. 278(28):26258-64
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. (2001) Nature 413, 78-83.
Dunne, A, Cunningham, O., Sabido, P., Lightner, D. and Mantle T.J. Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXa reductase and biliverdin-IXb reductase. (2000) J. Biol. Chem. 275, 19009-19017.