Luke O'Neill
Chair of Biochemistry(1960), Biochemistry
Biography
CURRICULUM VITAE
Name:
Luke A.J. O'Neill
Title: Professor (Chair of Biochemistry) Affiliations: School of Biochemistry and Immunology
Trinity College Dublin, Ireland Email: laoneill@tcd.ie
EDUCATION AND QUALIFICATIONS 1985: Awarded B.A. (Mod.) in Natural Sciences (Biochemistry) Trinity College Dublin, Ireland. Class: I 1988: Awarded PhD in Pharmacology, University of London
EMPLOYMENT
2011 Founder Director, Trinity Biomedical Sciences Institute 2007 Appointed to the Chair of Biochemistry, Trinity College Dublin 2005 Head, School of Biochemistry and Immunology, Trinity College Dublin
Appointed Professor of Molecular Immunology 2004 Head of Department of Biochemistry, Trinity College Dublin Appointed Science Foundation Ireland Research Professor
2002
Visiting Professor, Monash University, Australia 1999 Visiting Professor, Millennium Pharmaceuticals, Cambridge MA 1999 Associate Professor of Biochemistry, Trinity College Dublin 1996 Fellow, Trinity College Dublin 1991 - 1999
Lecturer in Biochemistry, Trinity College Dublin 1988 - 1991 Medical Research Council Post-doctoral fellow, Strangeways Research Laboratory, Cambridge, UK
AWARDS AND HONOURS
2005
Elected member of European Molecular Biology Organisation
2008 Appointed Chair of the European Research Council Infection and Immunity Panel
2009
Immunology 'Guru', National Institutes of Health
Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence
Science Foundation Ireland Researcher of the Year Award
2010
McGill University Dan Perry Award Lecture
University of Oxford Jenner Institute Distinguished Lecturer
Appointed Chair of the Programme Committee for Dublin European City of Science
European Open Science Forum Conference
2011
European Research Council Advanced Grant awardee
Appointed to Board of Reviewing Editors, Science
President, International Cytokine Society
2012
Royal Irish Academy Gold Medal for Life Sciences
2014
European Federation of Immunology Societies Medal
2015
Listed in Thompson / Reuters top 1% of scientists (2002- 2012) in Immunology and
Pharmacology/Toxicology based on citations
Visiting Fellow, Christ's College Cambridge
2016
Visiting Professor, GlaxoSmithKline, Stevenage, UK
Elected Fellow of the Royal Society (FRS)
2018
Milstein Award, International Cytokine and Interferon Society
CURRENT RESEARCH Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Immunometabolism and Metabolic Reprogramming in Immunity
Publications and Further Research Outputs
Peer-Reviewed Publications
Murphy, M.P. and O'Neill, L.A.J., Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers, Cell, 174, (4), 2018, p780-784
Perdisatt, L. and Moqadasi, S. and O'Neill, L. and Hessman, G. and Ghion, A. and Warraich, M.Q.M. and Casey, A. and O'Connor, C., Synthesis, characterisation and DNA intercalation studies of regioisomers of ruthenium (II) polypyridyl complexes, Journal of Inorganic Biochemistry, 182, 2018, p71-82
Kammoun, H.L. and Allen, T.L. and Henstridge, D.C. and Barre, S. and Coll, R.C. and Lancaster, G.I. and Cron, L. and Reibe, S. and Chan, J.Y. and Bensellam, M. and Laybutt, D.R. and Butler, M.S. and Robertson, A.A.B. and O'Neill, L.A. and Cooper, M.A. and Febbraio, M.A., Evidence against a role for NLRP3-driven islet inflammation in db/db mice, Molecular Metabolism, 10, 2018, p66-73
Angiari, S. and O'Neill, L.A., Dimethyl fumarate: Targeting glycolysis to treat MS, Cell Research, 28, (6), 2018, p613-615
O'Neill, L.A. and Cooper, M.A., Canakinumab for Atherosclerotic Disease, The New England journal of medicine, 378, (2), 2018, p198-199
O'Neill, L.A.J. and Zaslona, Z., Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3, Trends in Molecular Medicine, 24, (4), 2018, p335-337
Baardman, J. and Verberk, S.G.S. and Prange, K.H.M. and van Weeghel, M. and van der Velden, S. and Ryan, D.G. and WÃŒst, R.C.I. and Neele, A.E. and Speijer, D. and Denis, S.W. and Witte, M.E. and Houtkooper, R.H. and O'neill, L.A. and Knatko, E.V. and Dinkova-Kostova, A.T. and Lutgens, E. and de Winther, M.P.J. and Van den Bossche, J., A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia, Cell Reports, 25, (8), 2018, p2044-2052.e5
Runtsch, M.C. and O'Neill, L.A.J., GOTcha: LncRNA-ACOD1 targets metabolism during viral infection, Cell Research, 28, (2), 2018, p137-138
Williams, N.C. and O'Neill, L.A.J., A role for the krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation, Frontiers in Immunology, 9, (FEB), 2018, p00141-
Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117
Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 2018, pdoi:10.1093/ecco-jcc/jjy038
Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201
Hughes M.M, Mcgettrick A.F, O'Neill L.A.J, Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages, Microbiology Spectrum, 5, (1), 2017, p0044-
Thom, S.R. and Bhopale, V.M. and Yu, K. and Huang, W. and Kane, M.A. and Margolis, D.J. and O'Neill, L., Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability, Journal of Biological Chemistry, 292, (44), 2017, p18312-18324
Pankaj, S.K. and Bueno-Ferrer, C. and Misra, N.N. and O'Neill, L. and Bourke, P. and Cullen, P.J., Effects of cold plasma on surface, thermal and antimicrobial release properties of chitosan film, Journal of Renewable Materials, 5, (1), 2017, p14-20
Mills E.L, Kelly B, O'Neill L.A.J, Mitochondria are the powerhouses of immunity, Nature Immunology, 18, (5), 2017, p488 - 498
Kim, R.Y. and Pinkerton, J.W. and Essilfie, A.T. and Robertson, A.A.B. and Baines, K.J. and Brown, A.C. and Mayall, J.R. and Ali, M.K. and Starkey, M.R. and Hansbro, N.G. and Hirota, J.A. and Wood, L.G. and Simpson, J.L. and Knight, D.A. and Wark, P.A. and Gibson, P.G. and O'Neill, L.A.J. and Cooper, M.A. and Horvat, J.C. and Hansbro, P.M., Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma, American Journal of Respiratory and Critical Care Medicine, 196, (3), 2017, p283-297
Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017
Van den Bossche J, O'Neill L.A, Menon D, Macrophage Immunometabolism: Where Are We (Going)?, Trends in Immunology, 38, (6), 2017, p395-406
Wu, B.X. and Li, A. and Lei, L. and Kaneko, S. and Wallace, C. and Li, X. and Li, Z. and O'Neill, L., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis, Journal of Biological Chemistry, 292, (44), 2017, p18091-18097
Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J.C, Tye H, Biette K, Jedlicka P, Brodsky K.S, Gerich M.E, Mack M, Robertson A.A.B, Cooper M.A, Furuta G.T, Dinarello C.A, O'Neill L.A, Eltzschig H.K, Masters S.L, McNamee E.N, Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome, Journal of Experimental Medicine, 214, (6), 2017, p1737 - 1752
Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923-
O'Neill L, Immunometabolism and the land of milk and honey, Nature Reviews Immunology, 17, (4), 2017, p217-
Pankaj, S.K. and Bueno-Ferrer, C. and O'Neill, L. and Tiwari, B.K. and Bourke, P. and Cullen, P.J., Characterization of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Journal of Food Processing and Preservation, 41, (1), 2017
Menon, D. and Innes, A. and Oakley, A.J. and Dahlstrom, J.E. and Jensen, L.M. and BrÃŒstle, A. and Tummala, P. and Rooke, M. and Casarotto, M.G. and Baell, J.B. and Nguyen, N. and Xie, Y. and Cuellar, M. and Strasser, J. and Dahlin, J.L. and Walters, M.A. and Burgio, G. and O'Neill, L.A.J. and Board, P.G., GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity, Scientific Reports, 7, (1), 2017
ZasÅ'ona Z, Palsson-McDermott E.M, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran S.E, Peters-Golden M, O'Neill L.A.J, The induction of Pro-IL-1β by lipopolysaccharide requires endogenous prostaglandin E
Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831
Haneklaus M, O'Neil J.D, Clark A.R, Masters S.L, O'Neill L.A.J, The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome, Journal of Biological Chemistry, 292, (17), 2017, p6869 - 6881
Pinkerton J.W, Kim R.Y, Robertson A.A.B, Hirota J.A, Wood L.G, Knight D.A, Cooper M.A, O'Neill L.A.J, Horvat J.C, Hansbro P.M, Inflammasomes in the lung, Molecular Immunology, 86, 2017, p44-55
Ryan, D.G. and O'Neill, L.A.J., Krebs cycle rewired for macrophage and dendritic cell effector functions, FEBS Letters, 591, (19), 2017, p2992-3006
To, E.E. and Vlahos, R. and Luong, R. and Halls, M.L. and Reading, P.C. and King, P.T. and Chan, C. and Drummond, G.R. and Sobey, C.G. and Broughton, B.R.S. and Starkey, M.R. and Van Der Sluis, R. and Lewin, S.R. and Bozinovski, S. and O'Neill, L.A.J. and Quach, T. and Porter, C.J.H. and Brooks, D.A. and O'Leary, J.J. and Selemidis, S., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy, Nature Communications, 8, (1), 2017
Chen, W. and Foo, S.-S. and Zaid, A. and Teng, T.-S. and Herrero, L.J. and Wolf, S. and Tharmarajah, K. and Vu, L.D. and Van Vreden, C. and Taylor, A. and Freitas, J.R. and Li, R.W. and Woodruff, T.M. and Gordon, R. and Ojcius, D.M. and Nakaya, H.I. and Kanneganti, T.-D. and O'Neill, L.A.J. and Robertson, A.A.B. and King, N.J. and Suhrbier, A. and Cooper, M.A. and Ng, L.F.P. and Mahalingam, S., Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation, Nature Microbiology, 2, (10), 2017, p1435-1445
Kacprzyk, J. and Hughes, G.M. and Palsson-Mcdermott, E.M. and Quinn, S.R. and Puechmaille, S.J. and O'Neill, L.A.J. and Teeling, E.C., A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance, Acta Chiropterologica, 19, (2), 2017, p219-228
O'Neill L.A.J, The Hunger Games: Salmonella, Anorexia, and NLRP3, Cell Metabolism, 25, (2), 2017, p225 - 226
Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986
Nakhleh, J. and Christophides, G.K. and Osta, M.A. and O'Neill, L., The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae, Journal of Biological Chemistry, 292, (44), 2017, p18217-18226
C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316
Khalid, H. and Mukherjee, S.P. and O'Neill, L. and Byrne, H.J., Structural dependence of in vitro cytotoxicity, oxidative stress and uptake mechanisms of poly(propylene imine) dendritic nanoparticles, Journal of Applied Toxicology, 36, (3), 2016, p464-473
Joosten L.A.B, Abdollahi-Roodsaz S, Dinarello C.A, O'Neill L, Netea M.G, Toll-like receptors and chronic inflammation in rheumatic diseases: New developments, Nature Reviews Rheumatology, 12, (6), 2016, p344 - 357
McGettrick AF, Corcoran SE, Barry PJG, McFarland J, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LAJ, Nolan DP, The Trypanosoma brucei metabolite indolepyruvate decreases HIF-1 and glycolysis in macrophages as a mechanism of innate immune evasion, Proceedings of the National Academy of Sciences, U.S.A., 113, (48), 2016, pE7778 - E7787
Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240-
O'Neill L.A.J, Pearce E.J, Immunometabolism governs dendritic cell and macrophage function, Journal of Experimental Medicine, 213, (1), 2016, p15 - 23
Mills E.L, O'Neill L.A, Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal, European Journal of Immunology, 46, (1), 2016, p13 - 21
Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449
Medzhitov R, Belkaid Y, Davis M.M, Glimcher L, O'Neill L.A.J, Sallusto F, Immunology Gets out of the Box, Cell, 165, (4), 2016, p763 - 764
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787
Arts R.J.W, Novakovic B, ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng S.-C, Wang S.-Y, Habibi E, Gonçalves L.G, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk F.L, Williams D.L, van der Meer J.W.M, Logie C, O'Neill L.A, Dinarello C.A, Riksen N.P, van Crevel R, Clish C, Notebaart R.A, Joosten L.A.B, Stunnenberg H.G, Xavier R.J, Netea M.G, Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity, Cell Metabolism, 24, (6), 2016, p807 - 819
McIntyre J, Verma N.K, Smith R.J, Moore C, Nerl H, McEvoy N, Berner N, McGovern I, Khan U, Lyons P, O'Neill L, Nicolosi V, Duesberg G.S, Byrne H.J, Coleman J, Volkov Y, A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene, RSC Advances, 6, (70), 2016, p65299 - 65310
Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13
Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379
Corcoran S.E, O'Neill L.A.J, HIF1α and metabolic reprogramming in inflammation, Journal of Clinical Investigation, 126, (10), 2016, p3699 - 3707
O'Neill L.A.J, A Metabolic Roadblock in Inflammatory Macrophages, Cell Reports, 17, (3), 2016, p625 - 626
Arbore G, West E.E, Spolski R, Robertson A.A.B, Klos A, Rheinheimer C, Dutow P, Woodruff T.M, Yu Z.X, O'Neill L.A, Coll R.C, Sher A, Leonard W.J, Köhl J, Monk P, Cooper M.A, Arno M, Afzali B, Lachmann H.J, Cope A.P, Mayer-Barber K.D, Kemper C, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells, Science, 352, (6292), 2016
O'Neill L.A.J, Kishton R.J, Rathmell J, A guide to immunometabolism for immunologists, Nature Reviews Immunology, 16, (9), 2016, p553 - 565
Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427-
Basiorka A.A, McGraw K.L, Eksioglu E.A, Chen X, Johnson J, Zhang L, Zhang Q, Irvine B.A, Cluzeau T, Sallman D.A, Padron E, Komrokji R, Sokol L, Coll R.C, Robertson A.A.B, Cooper M.A, Cleveland J.L, O'Neill L.A, Wei S, List A.F, The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype, Blood, 128, (25), 2016, p2960 - 2975
Brady G, Boggan L, Bowie A, O'Neill L.A.J, Erratum: Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1 (The Journal of Biological Chemistry (2005) 280 (30723-30734) DOI: 10.1074/jbc.M500435200), Journal of Biological Chemistry, 291, (48), 2016, p25278-
O'Neill L.A.J, How Low Cholesterol Is Good for Anti-viral Immunity, Cell, 163, (7), 2015, p1572 - 1574
Kelly B, O'Neill L.A.J, Metabolic reprogramming in macrophages and dendritic cells in innate immunity, Cell Research, 25, (7), 2015, p771 - 784
Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992
Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260
Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80
Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679
O'Neill L.A.J, A Broken Krebs Cycle in Macrophages, Immunity, 42, (3), 2015, p393 - 394
Kelly B, Tannahill G.M, Murphy M.P, O'Neill L.A.J, Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages, Journal of Biological Chemistry, 290, (33), 2015, p20348 - 20359
Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA, Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1., Proceedings of the National Academy of Sciences of the United States of America, 112, (23), 2015, p7231-6
Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60
Norata G.D, Caligiuri G, Chavakis T, Matarese G, Netea M.G, Nicoletti A, O'Neill L.A.J, Marelli-Berg F.M, The Cellular and Molecular Basis of Translational Immunometabolism, Immunity, 43, (3), 2015, p421 - 434
Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347
Haneklaus M, O'Neill L.A.J, NLRP3 at the interface of metabolism and inflammation, Immunological Reviews, 265, (1), 2015, p53 - 62
Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257
Menon D, Coll R, O'Neill L.A.J, Board P.G, GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway, Journal of Cell Science, 128, (10), 2015, p1982 - 1990
Finucane O.M, Lyons C.L, Murphy A.M, Reynolds C.M, Klinger R, Healy N.P, Cooke A.A, Coll R.C, Mcallan L, Nilaweera K.N, O'Reilly M.E, Tierney A.C, Morine M.J, Alcala-Diaz J.F, Lopez-Miranda J, O'Connor D.P, O'Neill L.A, Mcgillicuddy F.C, Roche H.M, Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity, Diabetes, 64, (6), 2015, p2116 - 2128
O'Neill, L.A.J., Glycolytic reprogramming by TLRs in dendritic cells, Nature Immunology, 15, (4), 2014, p314-315
Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, mTOR- and HIF-1"-mediated aerobic glycolysis as metabolic basis for trained immunity., Science (New York, N.Y.), 345, (6204), 2014, p1250684
Mockler MB, Conroy MJ, Lysaght J, Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment., Frontiers in oncology, 4, 2014, p107
Greenhill CJ, Jones GW, Nowell MA, Newton Z, Harvey AK, Moideen AN, Collins FL, Bloom AC, Coll RC, Robertson AA, Cooper MA, Rosas M, Taylor PR, O'Neill LA, Humphreys IR, Williams AS, Jones SA, Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction., Arthritis research & therapy, 16, (4), 2014, p419
Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi & Luke A.J. O'Neill , Circadian Clock Proteins and Immunity, Immunity, Volume 40, (2), 2014, 178-186
van den Bosch MW, Palsson-Mcdermott E, Johnson DS, O'Neill LA, LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production., The Journal of biological chemistry, 289, (33), 2014, p22980-90
Galván-Peña S, O'Neill LA, Metabolic reprograming in macrophage polarization., Frontiers in immunology, 5, 2014, p420
Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA, Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation., The Journal of biological chemistry, 289, (10), 2014, p6429-37
d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816-
Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA., The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10., The Journel of Biological Chemistry, 289, (9), 2014, p4316-4325
Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA, The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10., The Journal of biological chemistry, 289, (7), 2014, p4316-25
Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67
Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919
Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437
Connolly DJ, O'Neill LA, McGettrick AF, The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling., The Journal of biological chemistry, 288, (8), 2013, p5616-5623
Mcgettrick, A.F., O'Neill, L.A.J., NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases, Diabetes, Obesity and Metabolism , 15, (S3), 2013, p19-25
Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928
McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, (32), 2013, 22893-22898
Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066
Haneklaus, M., Gerlic, M., O'Neill, L.A.J., Masters, S.L., miR-223: Infection, inflammation and cancer, Journal of Internal Medicine, 274, (3), 2013, p215-226
Palsson-Mcdermott, E.M., O'Neill, L.A.J., The Warburg effect then and now: From cancer to inflammatory diseases, BioEssays, 35, (11), 2013, p965-973
O'Neill LA, Hardie DG, Metabolism of inflammation limited by AMPK and pseudo-starvation., Nature, 493, (7432), 2013, p346-355
Adamik, J., Wang, K.Z.Q., Unlu, S., Su, A.-J.A., Tannahill, G.M., Galson, D.L., O'Neill, L.A., Auron, P.E., Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α, PLoS One, 8, (8), 2013, pe70622
Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45
O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, (5), 2013, p610-2
Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA, A long noncoding RNA mediates both activation and repression of immune response genes., Science (New York, N.Y.), 341, (6147), 2013, p789-92
Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+
O'Neill LA, Immunology. Sensing the dark side of DNA., Science (New York, N.Y.), 339, (6121), 2013, p763-764
Kenny, E.F., Quinn, S.R., Doyle, S.L., Vink, P.M., van Eenennaam, H., O'Neill, L.A.J., Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin, PLoS ONE, 8, (8), 2013, part. no. e74103
Mills, E., O'Neill, L.A.J., Succinate: a metabolic signal in inflammation, Trends in Cell Biology, 2013
O'Neill, L.A.J., Golenbock, D., Bowie, A.G., The history of Toll-like receptors-redefining innate immunity, Nature Reviews Immunology, 13, (6), 2013, p453-460
Bernard, N.J., O'Neill, L.A, Mal, more than a bridge to MyD88, IUBMB Life , 65, (9), 2013, p777-786
Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J. , Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104) (Erratum), 2013, - 17600
Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15., J. Biol. Chem., 288, (35), 2013, p25066 - 25075
Foley NH, O'Neill LA, miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes., Journal of leukocyte biology, 92, (3), 2012, p521-527
Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP, Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs., Circulation. Cardiovascular interventions, 5, (2), 2012, p279-287
Netea MG, Wijmenga C, O'Neill LA, Genetic variation in Toll-like receptors and disease susceptibility., Nature immunology, 13, (6), 2012, p535-542
Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798
Connolly DJ, O'Neill LA, New developments in Toll-like receptor targeted therapeutics., Current opinion in pharmacology, 12, (4), 2012, p510-518
Wen H, Ting JP, O'Neill LA, A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?, Nature immunology, 13, (4), 2012, p352-357
Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012
Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL, Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1ß production., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p3795-9
O'Neill LA, "Transflammation": when innate immunity meets induced pluripotency., Cell, 151, (3), 2012, p471-3
Dowling JK, O'Neill LA, Biochemical regulation of the inflammasome., Critical reviews in biochemistry and molecular biology, 47, (5), 2012, p424-443
Ward SG, O'Neill LA, Spurs in the hunt for new immunomodulatory drug targets., Current opinion in pharmacology, 12, (4), 2012, p439-443
Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299
Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation., Nature communications, 3, 2012, p707
Gillian M. Tannahill, Luke A.J. O'Neill, The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3, FEBS Letter, 585, (11), 2011, p1568-1572
Ultaigh SN, Saber TP, McCormick J, Connolly M, Dellacasagrande J, Keogh B, McCormack W, Reilly M, O'Neill LA, McGuirk P, Fearon U, Veale DJ, Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures., Arthritis research & therapy, 13, (1), 2011, pR33
Coll RC, O'Neill LA., The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes, PLoS ONE, 6, (12, e29539), 2011
Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA., Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6, Journal of Biological Chemistry, 286, (29), 2011, p25531-9
Durrani O, Banahan K, Sheedy FJ, McBride L, Ben-Chetrit E, Greiner K, Vaughan RW, Kondeatis E, Hamburger J, Fortune F, Stanford MR, Murray PI, O'Neill LA, Wallace GR, TIRAP Ser180Leu polymorphism is associated with Behcet's disease., Rheumatology , 50, (10), 2011, p1760-5
Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011
Nathalie Court, Stéphanie Rose, Marie-Laure Bourigault, Sophie Front, Olivier R. Martin, Jennifer K. Dowling, Elaine F. Kenny, Luke O'Neill, François Erard, Valerie F. J. Quesniaux, Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms, PLoS ONE, 6, (9, e24631), 2011
Carpenter S, Wochal P, Dunne A, O'Neill LA, Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL)., The Journal of Biological Chemistry, 286, (44), 2011, p38795-38804
O'Neill LA, Bowie AG, The powerstroke and camshaft of the RIG-I antiviral RNA detection machine., Cell, 147, (2), 2011, p259-261
Muhammad M. Alam and Luke A. O'Neill, MicroRNAs and the resolution phase of inflammation in macrophages, European Journal of Immunology, 41, (9), 2011, p2482-2485
O'Neill LA, Counter-regulation in the IKK family., The Biochemical Journal, 434, (1), 2011, pe1-2
O'Neill LA, A critical role for citrate metabolism in LPS signalling., The Biochemical journal, 438, (3 ), 2011, pe5-6
Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904
Madden SF, Carpenter SB, Jeffery IB, Bjorkbacka H, Fitzgerald KA, O'Neill LA, Higgins DG, Detecting microRNA activity from gene expression data., BMC Bioinformatics, 11, (1), 2010, p257
Zhang, X., Shephard, F., Kim, H.B., Palmer, I.R., McHarg, S., Fowler, G.J.S., O'Neill, L.A.J., (...), Qwarnstrom, E.E., TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-κB, Journal of Biological Chemistry, 285, (10), 2010, p7222-7232
McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, (27), 2010, p20492-20498
Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP., Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. , Circulation., 121, (1), 2010, p80-90
Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28
O'Neill, L.A.J., Hennessy, E.J., Parker, A.E, Targeting Toll-like receptors: Emerging therapeutics?, Nature Reviews Drug Discovery, 9, (4), 2010, p293-307
O'Neill, L.A.J., Bowie, A.G., Sensing and Signaling in Antiviral Innate Immunity , Current Biology , 20, (7), 2010, pR328-R333
Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147
Coll, R.C., O'Neill, L.A.J., New insights into the regulation of signalling by toll-like receptors and nod-like receptors, Journal of Innate Immunity, 2, (5), 2010, p406-421
YanMei Liang, Jeremy Hetzel, Ansu Noronha, Daniel Onguru, Susan Carpenter, Melanie Mott, Sherman Biogornia, Caroline Apovian, Noyan Gokce, Jennifer Coukos, Dennis Kasper, Luke O'Neill, Pauline Mwinzi, Francis Farraye, Marie McDonnell, Lisa Ganley-Leal., Systemic Toll-like receptor ligands modify B cell responses in human chronic inflammatory disease., Journal of Clinical Investigation., 2010, p1-10
O'Neill, L.A.J, Stopping sepsis by targeting sphingosine kinase 1, Science Translational Medicine, 2, (36), 2010, p36ps29
McGettrick AF, O'Neill LA, Localisation and trafficking of Toll-like receptors: an important mode of regulation. , Current Opinion in Immunology, 22, (1), 2010, p20-27
Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282
Uncovering novel gene function in TLR signalling using siRNA in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Carty, M., Keating, S. & Bowie, A.G. ]
Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709
Sheedy FJ, O'Neill LA., Adding fuel to fire: microRNAs as a new class of mediators of inflammation., Annals of the Rheumatic Diseases, 67 , (Suppl 3), 2009, piii50 - iii55
Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357
McCormack WJ, Parker AE, O'Neill LA., Toll-like receptors and NOD-like receptors in rheumatic diseases., Arthritis Research & Therapy , 11, (5), 2009, p243
Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875
Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995
Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586
Carpenter S, O'Neill LA , Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins., Biochemistry Journal, 422, (1), 2009, p1-10
Characterisation of viral proteins that inhibit TLR signal transduction in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Stack, J & Bowie, A.G.]
O'Neill LA, Bryant CE, Doyle SL, Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer., Pharmacological Reviews, 61, (2), 2009, p177-97
O'Neill LAJ and McCoy C, Toll-like receptor protocols. Methods in Molecular Medicine Series, 517, New Jersey USA , Humana Press, 2009
O'Neill LA, Boosting the brain's ability to block inflammation via microRNA-132., Immunity, 31, (6), 2009, p854-855
Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537
Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG., Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock, Proceedings of the National Academy of Science USA, 106, (25), 2009, p10272-10277
O'Neill LA, A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis?, Gastroenterology., 137, (6), 2009, p1889-1891
O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045
O'Neill LA, Regulation of signaling by non-degradative ubiquitination., The Journal of Biological Chemistry, 284, (13), 2009, p8209
O'Neill LA., DNA makes RNA makes innate immunity, Cell, 138, (3), 2009, p428-430
Sheedy FJ, Marinou I, O'Neill LA, Wilson AG., The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to or severity of rheumatoid arthritis., Ann Rheum Dis., 2008
O'Neill LAJ , When signalling pathways collide: positive and negative regulation of Toll-like receptor signalling, Immunity , 29, (1), 2008, p12 - 20
O'Neill LA, The interleukin-1 receptor / Toll-like receptor superfamily: ten years of progress, Immunological Reviews, 226, (1), 2008, p10 - 18
Brikos C, O'Neill LA. , Signalling of toll-like receptors., Handb Exp Pharmacol., 183, 2008, p21-50
McCoy CE, Carpenter S, Palsson-McDermott EM, Gearing J, O'Neill, LA, Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like, The Journal of Biological Chemistry, 283, 2008, p14277-14285
McCoy CE, O'Neill LA., The role of toll-like receptors in macrophages., Front Biosci., 1, (13), 2008, p62-70
O'Neill LAJ, Immunology. How frustration leads to inflammation., Science, 320, (5876), 2008, p619-20
O'Neill LA , Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?, Nat Clin Pract Rheumatol., 4, (6), 2008, p319-27
O'Neill L.A., Bacteria fight back against Toll-like receptors., Nat Med., 14, (4), 2008, p370-372
Kenny EF, O'Neill LA., Signalling adaptors used by Toll-like receptors: an update., Cytokine, 43, (3), 2008, p342 - 349
Chau TL, Gioia R, Gatot JS, Patrascu F, Carpentier I, Chapelle JP, O'Neill L, Beyaert R, Piette J, Chariot A, Are the IKKs and IKK-related kinases TBK1 and IKK-varepsilon similarly activated?, Trends Biochem Sci, 33, (4), 2008, p171-80
O'Neill LA, 'Fine tuning' TLR signaling, Nat Immunol. , 9, (5), 2008, p459-61
O'Neill, L.A., Innate Immunity: Squelching Anti-Viral Signalling with NLRXI, Curr Biol, 18, (7), 2008, pR302-R304
Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969
Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE., Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance, Journal of Biological Chemistry, 283, (6), 2008, p3109-19
Becker CE, O'Neill LA., Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs., Semin Immunopathol. , 29, (3), 2007, p239-48.
Wietek C, O'Neill LA., Diversity and regulation in the NF-kappaB system., Trends Biochem Sci., 32, (7), 2007, p311-319.
O'Neill LA., TAMpering with toll-like receptor signaling., Cell, 131, (6), 2007, p1039-41
O'Neill LA and Bowie AG, The family of five: TIR domain containing adapters in TLR signalling, Nat Rev Immunol, 7, 2007, p353-364
Palsson-McDermott EM, O'Neill LA. , The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60
McGettrick AF, O'Neill LA., Toll-like receptors: key activatory of leucocytes and regulator of haematopoiesis, Br J Haematol., 139, (2), 2007, p185-93
Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528
Doyle SL, Jefferies CA, Feighery C, O'Neill LA., Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase., Journal of Biological Chemistry, 282, (51), 2007, p36953-36960.
Watters TM, Kenny EF, O'Neill, LA., Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins., Immunol Cell Biol., 85, (6), 2007, p411-419.
Sheedy F. and O'Neill L.A., The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling, Journal of Leukocyte Biology, 82, (2), 2007, p196-203
Nuñez Miguel R, Wong J, Westolll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant, A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins., PLoS ONE, 2, (8), 2007, pe788.
Pålsson-McDermott EM, O'Neill LA., The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60
Carpenter S, O'Neill LA., How important are Toll-like receptors for antimicrobial responses?, Cell Microbiology, 9, (8), 2007, p1891-1901.
Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377
Constantinos Brikos, Robin Wait, Shajna Begum, Luke A. J. O'Neill, and Jeremy Saklatvala,, Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components, Molecular and Cellular Proteomics, 6, 2007, p1551-1559
Palsson-McDermott EM, O'Neill, LA. , Building an immune system from nine domains., Biochem Soc Trans., 35, (6), 2007, p1437-44
Gubster C, Goodbody R, Ecker A, Brady G, O'Neill LA, Jacobs N, Smith GL., Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus, Journal of General Virology, 88, (6), 2007, p1667-1676
McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201
Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O'Neill LA* and Hertzog P* , Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation, Nature Immunol., 7, (2), 2006, p148 - 155
O'Neill LA, Targetting signal transduction pathways as a strategy for anti-inflammatory drugs, Nature Reviews Drug Discovery, 2006
O'Neill LA, How Toll-like receptors signal: what we know and what we don't know, Current Opinion in Immunology, 18, (1), 2006, p3 - 9
O'Neill LA, DisSARMing Toll-like receptor signaling, Nat Immunol., 7, (10), 2006, p1023 - 1025
Miggin SM and O'Neill LA, New insights into the regulation of TLR signaling, Journal of Leukocyte Biology, 80, (2), 2006, p220 - 226
Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357
O'Neill LA, Targeting signal transduction as a strategy to treat inflammatory diseases, Nature Rev. Drug Disc, 5, (7), 2006, p549 - 563
Mansell A, Toynbee J, Gray P, Doyle S, Hilton D, O'Neill LA and Hertzog P, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation , Nature Immunology, 7, (2), 2006, p148 - 155
Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495
Doyle, SL and O'Neill LAJ, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol., 72, (9), 2006, p1102 - 1113
Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL, Resolution of inflammation: state of the art, definitions and terms, The FASEB Journal, 21, (2), 2006, p325 - 332
Wietek,C, Cleaver, CS, Ludbrook, V, Wilde, J, White, J, Bell, DJ, Lee, M, Dickson, M, Ray, KP and O'Neill, LAJ, IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65, The Journal of Biological Chemistry, 281, (46), 2006, p34973 - 34981
Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proceedings of the National Academy of Sciences , 103, (16), 2006, p6299 - 6304
O'Neill LA , Immunity's early warning system, Scientific American , 292, (1), 2005, p38 - 45
Liew, E, Xu, D, Brint, E, O'Neill, LA, Negative regulation of TLR signalling, Nature Rev. Immunol., 5, (6), 2005, p446 - 458
Panayi, G and O'Neill LA, Targetting innate and adaptive immunity in arthritis, New England Jounral of Medicine, 2005
O'NEILL LA et al, PCT application - 'Assays relating to Toll-like receptor-4 and compositions for modulating same', 2005
Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, Journal of Biological Chemistry, 280, (25), 2005, p23496 - 23501
Brady G, Boggan L, Bowie A and O'Neill LA, Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1, Journal of Biological Chemistry, 280, (35), 2005, p30723 - 30734
Dunne A and O'Neill LA, Adaptor usage and Toll-like receptor signaling specificity, FEBS Lett., 579, (15), 2005
O'Neill LA, TLRs play good cop bad cop in lung, Nature Medicine, 11, (11), 2005, p1161 - 1162
Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, J Biol Chem., 280, (25), 2005, p23496 - 23501
Dunne A and O'Neill L, New insights into the post-translational modification of Toll-like receptor, Journal of Endotoxin Research, 11, (6), 2005, p325 - 332
O'Toole D, Abde;-Latif AM, Long A, Windle HJ, Murphy AM, Bowie A, O'Neill LA, Weir DG, Kelleher D, Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?, Journal of Cellular Biochemistry, 96, (3), 2005, p589 - 588
O'NEILL LA et al, PCT application: 'TLR14 - a novel Toll-like receptor', 2005
Luke O'Neill and Elisabeth Brint (editors), Toll-like receptors in inflammation, Plenum Press, 2005
Hardy MP, McGettrick AF, O'Neill LAJ, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, Biochemical Journal, 380, (1), 2004, p83 - 93
Khan JA, Brint EK, O'Neill LAJ, Tong L, Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL, Journal of Biological Chemistry, 279, (30), 2004, p31664 - 31670
Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'Neill LAJ, Qwarnstrom EE, Dower SK, Human tribbles, a protein family controlling mitogen-activated protein kinase cascades, Journal of Biological Chemistry, 279, (41), 2004, p42703 - 42708
E. K. Brint, D. Xu, H. Liu, A. Dunne, A. N. McKenzie, L. A. O'Neill and F. Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nature immunology, 5, (4), 2004, p373-379
O'NEILL LUKE A J (Trinity College Dublin); SIMS JOHN E (Immunex); BIRD TIMOTHY A (Immunex), MyD88 adaptor-like proteins, 2004, WO 01/088137
A. F. McGettrick and L. A. O'Neill, The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction, Mol Immunol, 41, (6-7), 2004, p577-82
Mansell, A, Brint E, Gould, JA, O'Neill, LA and Hertzog, P, Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4, Journal of Biological Chemistry, 279, (36), 2004, p37227 - 37230
C. A. Jefferies and L. A. O'Neill, Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?, Immunology letters, 92, (38018), 2004, p15-22
E. M. Palsson-McDermott and L. A. O'Neill, Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4, Immunology, 113, (2), 2004, p153-62
L. A. O'Neill, Immunology. After the toll rush, Science, 303, (5663), 2004, p1481-2
L. A. O'Neill, How NOD-ing off leads to Crohn disease, Nature immunology, 5, (8), 2004, p776-8
Hardy, M, McGettrick, A and O'Neill, LAJ , Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene., Biochemical Journal, 380, (1), 2004, p83 - 93
O'Neill LA, Toll-like receptors: Professor Metchnikov, sit on your hat, Trends in Immunol, 125, (12), 2004, p687 - 693
Brint EK, Xu DM, Liu HY, Dunne A, McKenzie ANJ, O'Neill LAJ, Liew FY, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, NATURE IMMUNOLOGY, 5, (4), 2004, p373 - 379
M. P. Hardy and L. A. O'Neill, The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory, The Journal of biological chemistry, 279, (26), 2004, p27699-708
M. P. Hardy, G. A. F. Mc and L. A. O'Neill, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, The Biochemical journal, 380, (Pt 1), 2004, p83-93
O'NEILL LA et al., PCT application - "A52R - Orthopoxvirus, genes and products thereof", 2003
E. F. Dunn, N. J. Gay, A. F. Bristow, D. P. Gearing, L. A. O'Neill and X. Y. Pei, High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity, Biochemistry, 42, (37), 2003, p10938-10944
A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451
L. A. O'Neill, K. A. Fitzgerald and A. G. Bowie, The Toll-IL-1 receptor adaptor family grows to five members, Trends in immunology, 24, (6), 2003, p286-90
L. A. O'Neill, SIGIRR puts the brakes on Toll-like receptors., Nature immunology, 4, (9), 2003, p823-824
P. J. Hertzog, L. A. O'Neill and J. A. Hamilton, The interferon in TLR signaling: more than just antiviral, Trends in Immunology, 24, (10), 2003, p534-539
O'Neill LA , Antisense modulation of TLR-4 expression, Expert Opinion on Therapeutic Patents, 13, (12), 2003, p1887 - 1889
A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3
L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9
C. A. Jefferies, S. Doyle, C. Brunner, A. Dunne, E. Brint, C. Wietek, E. Walch, T. Wirth and L. A. O'Neill, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4, The Journal of Biological Chemistry, 278, (28), 2003, p26258-64
S. G. Ward and L. A. O'Neill, Spotlight on new anti-inflammatory drug targets in the immune system, Current opinion in pharmacology, 3, (4), 2003, p391-5
C. Wietek, S. M. Miggin, C. A. Jefferies and L. A. O'Neill, Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, The Journal of Biological Chemistry, 278, (51), 2003, p50923-50931
L. A. O'Neill, Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases, Current opinion in pharmacology, 3, (4), 2003, p396-403
L. A. O'Neill, The role of MyD88-like adapters in Toll-like receptor signal transduction, Biochemical Society Transactions, 31, (Pt 3), 2003, p643-637
O'NEILL LA et al., PCT application - "A46R - Orthopoxvirus, genes and products thereof"., 2003
L. A. O'Neill, Z. Brown and S. G. Ward, Toll-like receptors in the spotlight, Nature immunology, 4, (4), 2003, p299
Harte, MT, Haga, I, Maloney, G, Gray, P, Reading, PC, Bartlett, N, Smith, GL, Bowie, AG and O'Neill, LAJ , The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence, Journal of Experimental Medicine, 197, (3), 2003, p343 - 351
L. A. O'Neill, Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily, Current Topics in Microbiology and Immunology, 270, 2002, p47-61
E. P. McDermott and L. A. O'Neill, Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1, The Journal of Biological Chemistry, 277, (10), 2002, p7808-7815
Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211
V. Corrigall and L. A. O'Neill, Using immunotherapy to treat rheumatic diseases, Trends in immunology, 23, (8), 2002, p383-384
L. A. O'Neill, Wanted: a molecular basis for specificity in toll-like receptor signal transduction, Molecular cell, 10, (5), 2002, p969-971
Wietek, C and O'Neill, LAJ , IRAK-4: a new drug target in inflammation, sepsis and autoimmunity, Molecular Interventions, 2, (4), 2002, p212 - 215
L. A. O'Neill, Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?, Trends in immunology, 23, (6), 2002, p296-300
O'Neill, LAJ, Toll-like receptors and the danger hypothesis, Trends in Immunology, 22, (8), 2001, p421
O'Neill, L.A.J, Gob genes, mucus and asthma. , Trends in Immunology, 22, (7), 2001, p353
O'Neill, L.A.J, Vaccine safety concerns, Trends in Immunology, 22, (8), 2001, p420 - 421
E. Dunn, J. E. Sims, M. J. Nicklin and L. A. O'Neill, Annotating genes with potential roles in the immune system: six new members of the IL-1 family, Trends in Immunology, 22, (10), 2001, p533-536
O'Neill, L.A.J, Co-stimulating allergy, Trends in Immunology, 22, (4), 2001, p183
O'Neill, L.A.J, A role for leptin in autoimmunity, Trends in Pharmacological Sciences, 22, (7), 2001, p341
O'Neill, L.A.J, Crohn's disease gene is given the NOD, Trends in Immunology, 22, (8), 2001, p418 - 419
L. O'Neill, Specificity in the innate response: pathogen recognition by Toll-like receptor combinations, Trends in immunology, 22, (2), 2001, p70
A. Mansell, A. Reinicke, D. M. Worrall and L. A. O'Neill, The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4, FEBS letters, 508, (3), 2001, p313-317
O'Neill, L.A.J, A role for leptin in autoimmunity? , Trends in Immunology, 22, (7), 2001, p352
A. Mansell, N. Khelef, P. Cossart and L. A. O'Neill, Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt, The Journal of Biological Chemistry, 276, (47), 2001, p43597-43603
Commins S, O'Neill LA, O'Mara SM., The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., Neuroscience, 102, (2), 2001, p273 - 280
O'Neill, L.A.J, An AIDS vaccine in sight? , Trends in Immunology, 22, (5), 2001, p242
O'Neill, L.A.J, A roll-call of monocytic gene induction, Trends in Immunology, 22, (4), 2001, p182
O'Neill, L.A.J, Irish say no to Nice but yes to immunology, Trends in Immunology, 22, (8), 2001, p421
O'Neill, L.A.J. and Bowie, A.G. (editors) , Interleukin Protocols, New Jersey, USA, Methods in Molecular Medicine Series, Humana Press, 2001, 443pp
C. Jefferies, A. Bowie, G. Brady, E. L. Cooke, X. Li and L. A. O'Neill, Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1, Molecular and Cellular Biology, 21, (14), 2001, p4544-4552
K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83
BRINT, B, T1/ST2 SIGNAL TRANSDUCTION: ACTIVATION OF AP-1, JNK, P38 AND P42/P44 MAP KINASE BUT NOT NF-KAPPAB, unknown, 2001, ISI Web of Science, 2001, pp58 - 58
O'Neill, L.A.J, IL-1 versus TNF in arthritis?. , Trends in Immunology, 22, (7), 2001, p353-354
O'Neill, L.A.J, A vaccine for colorectral cancer, Trends in Immunology, 22, (7), 2001, p354
FITZGERALD, KA, MAL (MYD88 ADAPTER-LIKE) IS REQUIRED FOR TOLL-LIKE RECEPTOR-4 SIGNAL TRANSDUCTION, unknown, 2001, ISI Web of Science, 2001, pp33 - 33
Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572
O'Neill, LAJ, Fitzgerald, K, Gearing, AJH and Callard, R, Cytokine Factsbook, 2nd, London, U.K, Academic Press, 2001, 513pp
O'Neill, L.A.J, A gene for Crohn's disease is given the nod, Trends in Pharmacological Sciences, 22, (8), 2001, p398 - 399
B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, M. Lawler, L. O'Neill, D. Kelleher, H. P. Schwarz and O. P. Smith, Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, 110, (1), 2000, p130-134
L. O'Neill, The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence, Biochemical Society Transactions, 28, (5), 2000, p557-563
A. Bowie, E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower and L. A. O'Neill, A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling, Proceedings of the National Academy of Sciences of the United States of America, 97, (18), 2000, p10162-10167
L. A. O'Neill and C. A. Dinarello, The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense, Immunology today, 21, (5), 2000, p206-209
L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2000, (44), 2000, pRE1
M. P. Boland, K. A. Fitzgerald and L. A. O'Neill, Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells, The Journal of Biological Chemistry, 275, (33), 2000, p25231-25238
Omara, SM, O'Neill LAJ, The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250
K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology, 164, (4), 2000, p2053-2063
D. R. Caffrey, L. A. O'Neill and D. C. Shields, A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways, Protein Science, 9, (4), 2000, p655-670
A. Mansell, L. Braun, P. Cossart and L. A. O'Neill, A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages, Cellular microbiology, 2, (2), 2000, p127-136
E. M. Palsson, M. Popoff, M. Thelestam and L. A. O'Neill, Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1, The Journal of Biological Chemistry, 275, (11), 2000, p7818-7825
C. A. Jefferies and L. A. O'Neill, Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression, The Journal of Biological Chemistry, 275, (5), 2000, p3114-3120
E. J. Ryan, E. McNeela, M. Pizza, R. Rappuoli, L. O'Neill and K. H. Mills, Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity, Journal of Immunology (Baltimore, Md, 165, (10), 2000, p5750-9
K. A. Fitzgerald and L. A. O'Neill, The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence, Microbes and infection / Institut Pasteur, 2, (8), 2000, p933-943
A. G. Bowie and L. A. O'Neill, Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase, Journal of Immunology, 165, (12), 2000, p7180-7188
The IL1 receptor / Toll-like receptor superfamily in, editor(s)J Oppenheim and M Feldmann , The Cytokine Reference, Academic Press, 2000, pp1565 - 1586, [O'Neill, LAJ and Dower, SJ ]
J. M. O'Sullivan, A. Gribbin, J. Taylor, L. O'Neill, S. Cosgrove and J. G. Armstrong, Complications of treatment with local field external beam radiotherapy for localized prostate cancer, Clinical Oncology (Royal College of Radiologists (Great Britain)), 12, (4), 2000, p217-221
A. Bowie and L. A. O'Neill, Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries, Biochemical pharmacology, 59, (1), 2000, p13-23
A. Bowie and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products, Journal of Leukocyte Biology, 67, (4), 2000, p508-514
K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology , 164, (4), 2000, p2053-2063
D. R. Caffrey, L. A. O'Neill and D. C. Shields, The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades, Journal of Molecular Evolution, 49, (5), 1999, p567-582
C. Greene and L. O'Neill, Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA, Biochimica et biophysica acta, 1451, (1), 1999, p109-121
K. A. Fitzgerald and L. A. O'Neill, Characterization of CD44 induction by IL-1: a critical role for Egr-1, Journal of Immunology , 162, (8), 1999, p4920-4927
A. N. Coogan, L. A. O'Neill and J. J. O'Connor, The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro, Neuroscience, 93, (1), 1999, p57-69
Bowie A, O'Neill LA., Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries., Biochemical Pharmacology, 59, (1), 1999, p13 - 23
J. S. Matthews and L. A. O'Neill, Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1, Cytokine, 11, (9), 1999, p643-655
FITZGERALD, K, INTERLEUKIN-1 UPREGULATES EXPRESSION OF METASTASIS-ASSOCIATED VARIANT V6 IN THE HUMAN ENDOTHELIAL CELL LINE ECV304 BY A MECHANISM INVOLVING THE TRANSCRIPTION FACTOR EGR-1., unknown, 1998, 78, ISI Web of Science, 1998, pp16 - 16
PALSSON, EM, INHIBITION OF P38 AND P42/P44 MAPK BY CLOSTRIDIUM SORDELLII LETHAL TOXIN IN IL-1 STIMULATED T LYMPHOCYTES - A ROLE FOR A RAS SUBFAMILY G PROTEIN IN IL-1 SIGNALLING, unknown, 1998, 9, ISI Web of Science, 1998, pp457 - 457
M. P. Boland and L. A. O'Neill, Ceramide activates NFkappaB by inducing the processing of p105, The Journal of Biological Chemistry, 273, (25), 1998, p15494-15500
Brennan P, O'Neill LA., Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers., Biochemical Pharmacology, 55, (7), 1998, p965 - 973
O'Neill LA, Greene C., Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants., Journal of Leukocyte Biology , 63, (6), 1998, p650 - 657
McGowan AJ, Bowie AG, O'Neill LA, Cotter TG., The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult., Experimental Cell Research, 238, (1), 1998, p248 - 256
BOLAND, MP, TOPOISOMERASE II IS A TARGET FOR ANTHRACYCLINE-MEDIATED ACTIVATION OF NF KAPPA B, unknown, 1998, 78, ISI Web of Science, 1998, pp9 - 9
O'Neill LA, Matthews JS, Pålsson E, Jeffries C, Brennan P, Cantrell DA., Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase., Biochemical Society Transactions, 25, (4), 1998, pS578 - S578
O'Neill, LA, Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture., Biochemical Society Transactions, 25, (1), 1997, p295 - 302
Brennan P, O'Neill LA., 2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF kappa B by PDTC., Biochemical Journal, 320, (3), 1997, p975 - 981
A. G. Bowie, P. N. Moynagh and L. A. O'Neill, Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells, The Journal of biological chemistry, 272, (41), 1997, p25941-25950
M. A. O'Connell, D. Kelleher, R. M. Liskamp, N. Hall, L. A. O'Neill and A. Long, TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes, Cytokine, 9, (2), 1997, p83-92
Coogan, A, O'Neill, LAJ, The p38 MAP kinase inhibitor SB203580 antagonizes the inhibitory effect of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro, unknown, 1997, 501P, ISI Web of Science, 1997, ppP86 - P87
O'Connell MA, Kelleher D, Liskamp RM, Hall N, O'Neill LA, Long A., TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes., Cytokine, 9, (2), 1997, p83 - 92
M. P. Boland, S. J. Foster and L. A. O'Neill, Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells, The Journal of Biological Chemistry, 272, (20), 1997, p12952-12960
O'Neill LA, Kaltschmidt C., NF-kappa B: a crucial transcription factor for glial and neuronal cell function., Trends in Neurosciences, 20, (6), 1997, p252 - 258
Fitzgerald K, O'Neill LA., Induction of the adhesion molecule CD44 by the pro-inflammatory cytokine interleukin-1 in endothelial cells., Biochemical Society Transactions, 25, (2), 1997, pS185 - S185
Mahon TM, Matthews JS, O'Neill LA., Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells., Biochemical Journal, 325, (1), 1997, p39 - 45
Mahon TM, O'Neill LA., Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS81 - S81
Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20
O'Neill LA, Kelly VP., Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma., Biochemical Society Transactions, 23, (4), 1996, pS597 - S597
M. P. Boland, S. J. Foster and L. A. O'Neill, Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event, Biochemical Society Transactions, 24, (1), 1996, p1S
MATTHEWS, JS, P38 ACTIVATION AS A KEY EVENT IN THE INDUCTION OF IL2 BY IL1 IN T LYMPHOCYTES, unknown, 1996, 89, ISI Web of Science, 1996, ppAA398 - AA398
MATTHEWS, JS, THE EFFECT OF MAPKK INHIBITOR PD98059, THE P38MAPK INHIBITOR SB203580 AND THE SMALL G PROTEIN RAC 1 ON INTERLEUKIN 1 SIGNAL TRANSDUCTION IN T LYMPHOCYTES, unknown, 1996, 119, ISI Web of Science, 1996, ppP12 - P12
O'Neill, LAJ, Interleukin-1 signal transduction., Ineternational Journal of Clinical & Laboratory Research, 25, (4), 1996
McCarthy LM, O'Neill LA., Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS82 - S82
Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20
Brennan P, O'Neill LA., Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide., Biochemical Society Transactions, 24, (1), 1996, pS3 - S3
O'Neill, LAJ, Interleukin I receptors and signal transduction., Biochemical Society Transactions, 24, (1), 1996, p207 - 211
Dunican DJ, Griffiths R, Williams DC, O'Neill LA., Endothelin-1 increases arachidonic acid release in C6 glioma cells through a potassium-modulated influx of calcium., Journal of Neurochemistry, 67, (2), 1996, p830 - 837
FITZGERALD, K, INDUCTION OF THE ADHESION MOLECULE CD44 BY THE PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1 IN ENDOTHELIAL CELLS, unknown, 1996, 89, ISI Web of Science, 1996, ppF69 - F69
Mahon TM, O'Neill LA., Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A., Biochemical Society Transactions, 23, (1), 1995, pS111 - S111
Murphy, M and O'Neill, LAJ (eds), What is Life? The next 50 years, Cambridge, UK, Cambridge University Press, 1995
M. A. O'Connell, R. Cleere, A. Long, L. A. O'Neill and D. Kelleher, Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78, The Journal of biological chemistry, 270, (13), 1995, p7399-404
McCarthy LM, O'Neill LAJ, Effects of pertussis toxin and its binding subunit on IL-1 signaling in T-cells, Biochemical Society Transactions, 23, (1), 1995, pS112 - S112
Hassan J, O'Neill S, O'Neill LA, Pattison U, Reen DJ., Signalling via CD28 of human naive neonatal T lymphocytes., Clinical and Experimental Immunology, 102, (1), 1995, p192 - 198
DUNICAN, DJ, GRIFFITHS, R, ONEILL, LAJ, WILLIAMS, DC, DEPOLARIZING LEVELS OF KCI INHIBIT ENDOTHELIN-1-MEDIATED RELEASE OF ARACHIDONIC-ACID IN RAT C6 GLIOMA-CELLS, Biochemical Society Transactions, 23, (1), 1995, pS285 - S285
Maria A. O'Connell, Roisin Cleere , Aideen Long , Luke A. J. O'Neill , Dermot Kelleher , Cellular Proliferation and Activation of NFB Are Induced by Autocrine Production of Tumor Necrosis Factor in the Human T Lymphoma Line HuT 78 , Journal of Biological Chemistry, 270, (13), 1995, p7399 - 7404
Mahon TM, O'Neill LA., Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit., Journal of Biological Chemistry, 270, (48), 1995, p28557 - 28564
CUNNINGHAM, A, INHIBITION OF LONG-TERM POTENTIATION BY TUMOR-NECROSIS-FACTOR IN THE RAT DENTATE GYRUS IN-VITRO, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P6
Cleere R, Long A, Kelleher D, O'Neill LA., Autocrine regulation of the transcription factor NF kappa B by TNF alpha in the human T cell lymphoma line Hut 78., Biochemical Society Transactions, 23, (1), 1995, pS113 - S113
Brennan P, O'Neill LA., Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals., Biochimica et Biophysica Acta (BBA) -Gene Structure and expression, 1260, (2), 1995, p167 - 175
O'Neill, LAJ, Towards an understanding of the signal transduction pathways for interleukin 1., Biochimica et Biophysica Acta (BBA) , 1266, (1), 1995
Kelly VP and O'Neill LA, Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma, Biochemical Society Transactions, 23, (4), 1995, p597S - 597S
Moynagh PN, Williams DC, O'Neill LA., Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants., Journal of Immunology, 153, (6), 1994, p2681 - 2690
O'Neill, LAJ, Murphy, M and Gallagher, RB , What are we? Where did we come from? Where are we going?, Science , 263, (5144), 1994, p181 - 183
P. N. Moynagh, D. C. Williams and L. A. O'Neill, Interleukin-1 activates transcription factor NF kappa B in glial cells, The Biochemical Journal, 294 , (2), 1993, p343-347
Moynagh PN, O'Neill LA, Williams DC., Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells., Biochemical Pharmacology, 46, (5), 1993, p821 - 827
O'Neill, LAJ , Interleukin 1, a central mediator of inflammation, Journal of Biomedical Science, 3, 1992, p7 - 12
O'Neill, LAJ, Ikebe, T, SJ Sarsfield and Saklatvala, J, , The binding sub-unit of pertussis toxin inhibits IL1 induction of IL2 and prostaglandin production, Journal of Immunology, 148, (2), 1992, p474 - 479
Luke A J O'Neill, How does interleukin-1 activate cells?, Kidney International , 41, 1992, p546 - 549
Stylianou E, O'Neill LA, Rawlinson L, Edbrooke MR, Woo P, Saklatvala J., Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes., Journla of Biological Chemistry, 267, (22), 1992, p15836 - 15841
O'Neill, LAJ, Bird, TA, Gearing, AJH and Saklatvala, J, Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). , J Biol Chem , 265, (6), 1990, p3146 - 3152
Laben JK, Legal issues related to the right to die: implications for nursing education., Deans Notes, 12, (2), 1990, p1-2
Saklatvala, J, Bird, TA, Kaur, P and O'Neill, LAJ , IL1 signal transduction: evidence of activation of G protein and protein kinase, Progress in Clinical Biological Research, 349, 1990, p285 - 295
O'Neill, LAJ, Bird, TA and Saklatvala, J, Interleukin 1 signal transduction, Immunol Today , 11, 1990, p392 - 394
O'Neill, LAJ and Lewis, GP, Interleukin-1 potentiates bradykinin- and TNF- induced PGE2 release, European Journal of Pharmacology, 166, (2), 1989, p131 - 137
O'Neill, LAJ and Lewis, GP, Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced PGE2 release: a novel effect on free arachidonic acid levels in human synovial cells, Biochem Pharmacol , 38, (21), 1989, p3707 - 3711
O'Neill, LAJ, Barratt, ML and Lewis, GP, Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect, British Journal of Clinical Pharmacology, 23, (1), 1987, p81 - 83
O'Neill, LAJ, Barratt, ML and Lewis, GP, Induction of cyclooxygenase by interleukin-1 in rheumatoid synovial cells., FEBS Letts , 212, (1), 1987, p35 - 39
Non-Peer-Reviewed Publications
O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD
O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCD
Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S.
Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125S
A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2S
A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109S
Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993
Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390S
Hughes, O'Neill, Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling, Proceedings of the National Academy of Sciences of the United States of America
Research Expertise
Description
CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Inflammasomes. Immunometabolism.Projects
- Title
- Control of TLRs and NLRs by microRNAs
- Funding Agency
- SFI
- Title
- Role of Nlrp3 in Type 2 diabetes
- Title
- . Novel proteins in the TLR and NLR systems
- Title
- Role of metabolism in innate immunity
- Title
- Circadian control of innate immunity
Recognition
Representations
External examiner for 40 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).
External examiner for degree programme in Molecular Medicine, University of Wales
Section Editor for Journal of Leukocyte Biology
Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence
Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.
Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.
Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme
Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's
Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine
Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)
Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA
Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA
Member of Medical Research Council Advisory Board, UK
Member Avenir Committee INSERM, French National Insitute of Health
Member, Science Foundation Ireland Biotechnology Advisory Board
Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases
Member of the Pre-clinical committee, Irish Medicines Board
Member, Royal Irish Academy Life Sciences Committee
Member, Arthritis Foundation of Ireland academic advisory committee
Awards and Honours
Irish Society for Immunology Medal for Immunology
Elected Member of the Royal Irish Academy
Dublin Institute of Molecular Medicine Medal Lecture
Charnock Bradley Award Lecture, University of Edinburgh
Elected President, Biomedical Sciences Section, British Association for the Advancement of Science
Elected Councillor, International Cytokine Society
Dolph Adams Award, Society for Leukocyte Biology USA
Shortlisted for the Boyle Medal, Royal Dublin Society
Short-listed for the Boyle Medal, Royal Dublin Society
Young Investigator Award, International Cytokine Society
Royal Irish Academy Medal for Biochemistry
Fellow, Trinity College Dublin
Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland
Elected member of European Molecular Biology Organisation (EMBO)
Appointed Chair of the European Research Council Infection and Immunity Panel
Appointed Councillor of the International Cytokine Society(and rising to President in 2012)
Immunology 'Guru', National Institutes of Health
Advisor to the 2009 Nobel Committee for Physiology or Medicine
Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence
Science Foundation Ireland Researcher of the Year Award
McGill University Dan Perry Award Lecture
University of Oxford Jenner Institute Distinguished Lecturer
President, International Cytokine Society
Royal Irish Academy Gold Medal for Life Sciences
European Federation of Immunology Societies Medal
Visiting Fellow, Christ's College Cambridge
Fellow of the Royal Society (FRS)
International Cytokine and Interferon Society Milstein Award
Queen's University Belfast Barcroft Medal
Nobel Assembly, Karolinska Institute Research Lecture
Austrian Academy of Sciences Landsteiner Award
Memberships
International Cytokine Society (Councillor)
Biochemical Society
American Society for Biochemistry and Molecular Biology
Member Royal Irish Academy Life Sciences Committee
Member of the Pre-clinical committee, Irish Medicines Board
Member of MRC Advisory Board, UK
Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA