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Luke O'Neill
Chair of Biochemistry(1960), Biochemistry

Biography

CURRICULUM VITAE

Name:

Luke A.J. O'Neill

Title: Professor (Chair of Biochemistry) Affiliations: School of Biochemistry and Immunology

Trinity College Dublin, Ireland Email: laoneill@tcd.ie

EDUCATION AND QUALIFICATIONS 1985: Awarded B.A. (Mod.) in Natural Sciences (Biochemistry) Trinity College Dublin, Ireland. Class: I 1988: Awarded PhD in Pharmacology, University of London

EMPLOYMENT

2011 Founder Director, Trinity Biomedical Sciences Institute 2007 Appointed to the Chair of Biochemistry, Trinity College Dublin 2005 Head, School of Biochemistry and Immunology, Trinity College Dublin

Appointed Professor of Molecular Immunology 2004 Head of Department of Biochemistry, Trinity College Dublin Appointed Science Foundation Ireland Research Professor

2002

Visiting Professor, Monash University, Australia 1999 Visiting Professor, Millennium Pharmaceuticals, Cambridge MA 1999 Associate Professor of Biochemistry, Trinity College Dublin 1996 Fellow, Trinity College Dublin 1991 - 1999

Lecturer in Biochemistry, Trinity College Dublin 1988 - 1991 Medical Research Council Post-doctoral fellow, Strangeways Research Laboratory, Cambridge, UK

AWARDS AND HONOURS

2005

Elected member of European Molecular Biology Organisation

2008 Appointed Chair of the European Research Council Infection and Immunity Panel

2009

Immunology 'Guru', National Institutes of Health

Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence

Science Foundation Ireland Researcher of the Year Award

2010

McGill University Dan Perry Award Lecture

University of Oxford Jenner Institute Distinguished Lecturer

Appointed Chair of the Programme Committee for Dublin European City of Science

European Open Science Forum Conference

2011

European Research Council Advanced Grant awardee

Appointed to Board of Reviewing Editors, Science

President, International Cytokine Society

2012

Royal Irish Academy Gold Medal for Life Sciences

2014

European Federation of Immunology Societies Medal

2015

Listed in Thompson / Reuters top 1% of scientists (2002- 2012) in Immunology and

Pharmacology/Toxicology based on citations

Visiting Fellow, Christ's College Cambridge

2016

Visiting Professor, GlaxoSmithKline, Stevenage, UK

Elected Fellow of the Royal Society (FRS)

2018

Milstein Award, International Cytokine and Interferon Society

CURRENT RESEARCH Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Immunometabolism and Metabolic Reprogramming in Immunity

Publications and Further Research Outputs

Peer-Reviewed Publications

Murphy, M.P. and O'Neill, L.A.J., Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers, Cell, 174, (4), 2018, p780-784 Journal Article, 2018 DOI

Perdisatt, L. and Moqadasi, S. and O'Neill, L. and Hessman, G. and Ghion, A. and Warraich, M.Q.M. and Casey, A. and O'Connor, C., Synthesis, characterisation and DNA intercalation studies of regioisomers of ruthenium (II) polypyridyl complexes, Journal of Inorganic Biochemistry, 182, 2018, p71-82 Journal Article, 2018 DOI

Kammoun, H.L. and Allen, T.L. and Henstridge, D.C. and Barre, S. and Coll, R.C. and Lancaster, G.I. and Cron, L. and Reibe, S. and Chan, J.Y. and Bensellam, M. and Laybutt, D.R. and Butler, M.S. and Robertson, A.A.B. and O'Neill, L.A. and Cooper, M.A. and Febbraio, M.A., Evidence against a role for NLRP3-driven islet inflammation in db/db mice, Molecular Metabolism, 10, 2018, p66-73 Journal Article, 2018 DOI

Angiari, S. and O'Neill, L.A., Dimethyl fumarate: Targeting glycolysis to treat MS, Cell Research, 28, (6), 2018, p613-615 Journal Article, 2018 DOI

O'Neill, L.A. and Cooper, M.A., Canakinumab for Atherosclerotic Disease, The New England journal of medicine, 378, (2), 2018, p198-199 Journal Article, 2018 DOI

O'Neill, L.A.J. and Zaslona, Z., Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3, Trends in Molecular Medicine, 24, (4), 2018, p335-337 Journal Article, 2018 DOI

Baardman, J. and Verberk, S.G.S. and Prange, K.H.M. and van Weeghel, M. and van der Velden, S. and Ryan, D.G. and WÃŒst, R.C.I. and Neele, A.E. and Speijer, D. and Denis, S.W. and Witte, M.E. and Houtkooper, R.H. and O'neill, L.A. and Knatko, E.V. and Dinkova-Kostova, A.T. and Lutgens, E. and de Winther, M.P.J. and Van den Bossche, J., A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia, Cell Reports, 25, (8), 2018, p2044-2052.e5 Journal Article, 2018 DOI

Runtsch, M.C. and O'Neill, L.A.J., GOTcha: LncRNA-ACOD1 targets metabolism during viral infection, Cell Research, 28, (2), 2018, p137-138 Journal Article, 2018 DOI

Williams, N.C. and O'Neill, L.A.J., A role for the krebs cycle intermediate citrate in metabolic reprogramming in innate immunity and inflammation, Frontiers in Immunology, 9, (FEB), 2018, p00141- Journal Article, 2018 DOI TARA - Full Text

Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 Journal Article, 2018 DOI

Daniel G.W. Johnston, Christoph A. Thaiss, Raul Cabrera-Rubio, Michelle A. Williams, Paul D. Cotter, Eran Elinav, Luke A.J. O'Neill, Sinéad C. Corr, Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis., Journal of Crohns and Colitis, 2018, pdoi:10.1093/ecco-jcc/jjy038 Journal Article, 2018

Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 Journal Article, 2017 DOI TARA - Full Text

Hughes M.M, Mcgettrick A.F, O'Neill L.A.J, Glutathione and glutathione transferase omega 1 as key posttranslational regulators in macrophages, Microbiology Spectrum, 5, (1), 2017, p0044- Journal Article, 2017 URL DOI

Thom, S.R. and Bhopale, V.M. and Yu, K. and Huang, W. and Kane, M.A. and Margolis, D.J. and O'Neill, L., Neutrophil microparticle production and inflammasome activation by hyperglycemia due to cytoskeletal instability, Journal of Biological Chemistry, 292, (44), 2017, p18312-18324 Journal Article, 2017 DOI

Pankaj, S.K. and Bueno-Ferrer, C. and Misra, N.N. and O'Neill, L. and Bourke, P. and Cullen, P.J., Effects of cold plasma on surface, thermal and antimicrobial release properties of chitosan film, Journal of Renewable Materials, 5, (1), 2017, p14-20 Journal Article, 2017 DOI

Mills E.L, Kelly B, O'Neill L.A.J, Mitochondria are the powerhouses of immunity, Nature Immunology, 18, (5), 2017, p488 - 498 Journal Article, 2017 URL DOI

Kim, R.Y. and Pinkerton, J.W. and Essilfie, A.T. and Robertson, A.A.B. and Baines, K.J. and Brown, A.C. and Mayall, J.R. and Ali, M.K. and Starkey, M.R. and Hansbro, N.G. and Hirota, J.A. and Wood, L.G. and Simpson, J.L. and Knight, D.A. and Wark, P.A. and Gibson, P.G. and O'Neill, L.A.J. and Cooper, M.A. and Horvat, J.C. and Hansbro, P.M., Role for NLRP3 inflammasome-mediated, IL-1β-dependent responses in severe, steroid-resistant asthma, American Journal of Respiratory and Critical Care Medicine, 196, (3), 2017, p283-297 Journal Article, 2017 DOI

Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017 Journal Article, 2017 DOI

Van den Bossche J, O'Neill L.A, Menon D, Macrophage Immunometabolism: Where Are We (Going)?, Trends in Immunology, 38, (6), 2017, p395-406 Journal Article, 2017 DOI URL

Wu, B.X. and Li, A. and Lei, L. and Kaneko, S. and Wallace, C. and Li, X. and Li, Z. and O'Neill, L., Glycoprotein A repetitions predominant (GARP) positively regulates transforming growth factor (TGF) β3 and is essential for mouse palatogenesis, Journal of Biological Chemistry, 292, (44), 2017, p18091-18097 Journal Article, 2017 DOI

Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson J.C, Tye H, Biette K, Jedlicka P, Brodsky K.S, Gerich M.E, Mack M, Robertson A.A.B, Cooper M.A, Furuta G.T, Dinarello C.A, O'Neill L.A, Eltzschig H.K, Masters S.L, McNamee E.N, Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome, Journal of Experimental Medicine, 214, (6), 2017, p1737 - 1752 Journal Article, 2017 URL DOI

Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923- Journal Article, 2017 TARA - Full Text DOI

O'Neill L, Immunometabolism and the land of milk and honey, Nature Reviews Immunology, 17, (4), 2017, p217- Journal Article, 2017 DOI URL

Pankaj, S.K. and Bueno-Ferrer, C. and O'Neill, L. and Tiwari, B.K. and Bourke, P. and Cullen, P.J., Characterization of Dielectric Barrier Discharge Atmospheric Air Plasma Treated Chitosan Films, Journal of Food Processing and Preservation, 41, (1), 2017 Journal Article, 2017 DOI

Menon, D. and Innes, A. and Oakley, A.J. and Dahlstrom, J.E. and Jensen, L.M. and BrÃŒstle, A. and Tummala, P. and Rooke, M. and Casarotto, M.G. and Baell, J.B. and Nguyen, N. and Xie, Y. and Cuellar, M. and Strasser, J. and Dahlin, J.L. and Walters, M.A. and Burgio, G. and O'Neill, L.A.J. and Board, P.G., GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity, Scientific Reports, 7, (1), 2017 Journal Article, 2017 TARA - Full Text DOI

ZasÅ'ona Z, Palsson-McDermott E.M, Menon D, Haneklaus M, Flis E, Prendeville H, Corcoran S.E, Peters-Golden M, O'Neill L.A.J, The induction of Pro-IL-1β by lipopolysaccharide requires endogenous prostaglandin E2 production, Journal of Immunology, 198, (9), 2017, p3558 - 3564 Journal Article, 2017 DOI URL

Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831 Journal Article, 2017 DOI

Haneklaus M, O'Neil J.D, Clark A.R, Masters S.L, O'Neill L.A.J, The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome, Journal of Biological Chemistry, 292, (17), 2017, p6869 - 6881 Journal Article, 2017 URL DOI

Pinkerton J.W, Kim R.Y, Robertson A.A.B, Hirota J.A, Wood L.G, Knight D.A, Cooper M.A, O'Neill L.A.J, Horvat J.C, Hansbro P.M, Inflammasomes in the lung, Molecular Immunology, 86, 2017, p44-55 Journal Article, 2017 URL DOI

Ryan, D.G. and O'Neill, L.A.J., Krebs cycle rewired for macrophage and dendritic cell effector functions, FEBS Letters, 591, (19), 2017, p2992-3006 Journal Article, 2017 DOI

To, E.E. and Vlahos, R. and Luong, R. and Halls, M.L. and Reading, P.C. and King, P.T. and Chan, C. and Drummond, G.R. and Sobey, C.G. and Broughton, B.R.S. and Starkey, M.R. and Van Der Sluis, R. and Lewin, S.R. and Bozinovski, S. and O'Neill, L.A.J. and Quach, T. and Porter, C.J.H. and Brooks, D.A. and O'Leary, J.J. and Selemidis, S., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy, Nature Communications, 8, (1), 2017 Journal Article, 2017 TARA - Full Text DOI

Chen, W. and Foo, S.-S. and Zaid, A. and Teng, T.-S. and Herrero, L.J. and Wolf, S. and Tharmarajah, K. and Vu, L.D. and Van Vreden, C. and Taylor, A. and Freitas, J.R. and Li, R.W. and Woodruff, T.M. and Gordon, R. and Ojcius, D.M. and Nakaya, H.I. and Kanneganti, T.-D. and O'Neill, L.A.J. and Robertson, A.A.B. and King, N.J. and Suhrbier, A. and Cooper, M.A. and Ng, L.F.P. and Mahalingam, S., Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation, Nature Microbiology, 2, (10), 2017, p1435-1445 Journal Article, 2017 DOI

Kacprzyk, J. and Hughes, G.M. and Palsson-Mcdermott, E.M. and Quinn, S.R. and Puechmaille, S.J. and O'Neill, L.A.J. and Teeling, E.C., A Potent Anti-Inflammatory Response in Bat Macrophages May Be Linked to Extended Longevity and Viral Tolerance, Acta Chiropterologica, 19, (2), 2017, p219-228 Journal Article, 2017 DOI

O'Neill L.A.J, The Hunger Games: Salmonella, Anorexia, and NLRP3, Cell Metabolism, 25, (2), 2017, p225 - 226 Journal Article, 2017 DOI URL

Sulaiman, G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blacksheilds G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee M, Campbell EL, Moynagh P, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ and Gallagher MF. , MyD88 is an essential component of retinoic acid induced differentiation in human pluripotent embryonal carcinoma cells. , Cell Death & Differentiation , 24, (11), 2017, p1975 - 1986 Journal Article, 2017

Nakhleh, J. and Christophides, G.K. and Osta, M.A. and O'Neill, L., The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae, Journal of Biological Chemistry, 292, (44), 2017, p18217-18226 Journal Article, 2017 DOI

C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316 Journal Article, 2017 TARA - Full Text

Khalid, H. and Mukherjee, S.P. and O'Neill, L. and Byrne, H.J., Structural dependence of in vitro cytotoxicity, oxidative stress and uptake mechanisms of poly(propylene imine) dendritic nanoparticles, Journal of Applied Toxicology, 36, (3), 2016, p464-473 Journal Article, 2016 DOI

Joosten L.A.B, Abdollahi-Roodsaz S, Dinarello C.A, O'Neill L, Netea M.G, Toll-like receptors and chronic inflammation in rheumatic diseases: New developments, Nature Reviews Rheumatology, 12, (6), 2016, p344 - 357 Journal Article, 2016 URL DOI

McGettrick AF, Corcoran SE, Barry PJG, McFarland J, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LAJ, Nolan DP, The Trypanosoma brucei metabolite indolepyruvate decreases HIF-1 and glycolysis in macrophages as a mechanism of innate immune evasion, Proceedings of the National Academy of Sciences, U.S.A., 113, (48), 2016, pE7778 - E7787 Journal Article, 2016 URL

Gray P, Dunne A, Brikos C, Jefferies C.A, Doyle S.L, O'Neill L.A.J, Erratum: MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction (Journal of Biological Chemistry (2006) 281 (10489-10495) DOI: 10.1074/jbc.M508892200), Journal of Biological Chemistry, 291, (50), 2016, p26240- Journal Article, 2016 URL DOI

O'Neill L.A.J, Pearce E.J, Immunometabolism governs dendritic cell and macrophage function, Journal of Experimental Medicine, 213, (1), 2016, p15 - 23 Journal Article, 2016 URL DOI

Mills E.L, O'Neill L.A, Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal, European Journal of Immunology, 46, (1), 2016, p13 - 21 Journal Article, 2016 URL DOI

Gleeson LE, Sheedy FJ, Palsson-McDermott EM, Triglia D, O'Leary SM, O'Sullivan MP, O'Neill LA, Keane J, Cutting Edge: Mycobacterium tuberculosis Induces Aerobic Glycolysis in Human Alveolar Macrophages That Is Required for Control of Intracellular Bacillary Replication., Journal of immunology (Baltimore, Md. : 1950), 196, (6), 2016, p2444-2449 Journal Article, 2016 TARA - Full Text URL DOI

Medzhitov R, Belkaid Y, Davis M.M, Glimcher L, O'Neill L.A.J, Sallusto F, Immunology Gets out of the Box, Cell, 165, (4), 2016, p763 - 764 Journal Article, 2016 URL DOI

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Arts R.J.W, Novakovic B, ter Horst R, Carvalho A, Bekkering S, Lachmandas E, Rodrigues F, Silvestre R, Cheng S.-C, Wang S.-Y, Habibi E, Gonçalves L.G, Mesquita I, Cunha C, van Laarhoven A, van de Veerdonk F.L, Williams D.L, van der Meer J.W.M, Logie C, O'Neill L.A, Dinarello C.A, Riksen N.P, van Crevel R, Clish C, Notebaart R.A, Joosten L.A.B, Stunnenberg H.G, Xavier R.J, Netea M.G, Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity, Cell Metabolism, 24, (6), 2016, p807 - 819 Journal Article, 2016 DOI URL

McIntyre J, Verma N.K, Smith R.J, Moore C, Nerl H, McEvoy N, Berner N, McGovern I, Khan U, Lyons P, O'Neill L, Nicolosi V, Duesberg G.S, Byrne H.J, Coleman J, Volkov Y, A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene, RSC Advances, 6, (70), 2016, p65299 - 65310 Journal Article, 2016 TARA - Full Text DOI URL

Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13 Journal Article, 2016 URL DOI

Ní Cheallaigh, C., Sheedy, F.J., Harris, J., Muñoz-Wolf, N., Lee, J., West, K., McDermott, E.P., Smyth, A., Gleeson, L.E., Coleman, M., Martinez, N., Hearnden, C.H., Tynan, G.A., Carroll, E.C., Jones, S.A., Corr, S.C., Bernard, N.J., Hughes, M.M., Corcoran, S.E., O'Sullivan, M., Fallon, C.M., Kornfeld, H., Golenbock, D., Gordon, S.V., O'Neill, L.A., Keane, J. Lavelle, E.C, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368 - 379 Journal Article, 2016 TARA - Full Text URL

Corcoran S.E, O'Neill L.A.J, HIF1α and metabolic reprogramming in inflammation, Journal of Clinical Investigation, 126, (10), 2016, p3699 - 3707 Journal Article, 2016 DOI URL

O'Neill L.A.J, A Metabolic Roadblock in Inflammatory Macrophages, Cell Reports, 17, (3), 2016, p625 - 626 Journal Article, 2016 TARA - Full Text URL DOI

Arbore G, West E.E, Spolski R, Robertson A.A.B, Klos A, Rheinheimer C, Dutow P, Woodruff T.M, Yu Z.X, O'Neill L.A, Coll R.C, Sher A, Leonard W.J, Köhl J, Monk P, Cooper M.A, Arno M, Afzali B, Lachmann H.J, Cope A.P, Mayer-Barber K.D, Kemper C, T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells, Science, 352, (6292), 2016 Journal Article, 2016 DOI URL

O'Neill L.A.J, Kishton R.J, Rathmell J, A guide to immunometabolism for immunologists, Nature Reviews Immunology, 16, (9), 2016, p553 - 565 Journal Article, 2016 URL DOI

Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427- Journal Article, 2016 URL DOI

Basiorka A.A, McGraw K.L, Eksioglu E.A, Chen X, Johnson J, Zhang L, Zhang Q, Irvine B.A, Cluzeau T, Sallman D.A, Padron E, Komrokji R, Sokol L, Coll R.C, Robertson A.A.B, Cooper M.A, Cleveland J.L, O'Neill L.A, Wei S, List A.F, The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype, Blood, 128, (25), 2016, p2960 - 2975 Journal Article, 2016 DOI URL

Brady G, Boggan L, Bowie A, O'Neill L.A.J, Erratum: Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1 (The Journal of Biological Chemistry (2005) 280 (30723-30734) DOI: 10.1074/jbc.M500435200), Journal of Biological Chemistry, 291, (48), 2016, p25278- Journal Article, 2016 DOI URL

O'Neill L.A.J, How Low Cholesterol Is Good for Anti-viral Immunity, Cell, 163, (7), 2015, p1572 - 1574 Journal Article, 2015 DOI URL

Kelly B, O'Neill L.A.J, Metabolic reprogramming in macrophages and dendritic cells in innate immunity, Cell Research, 25, (7), 2015, p771 - 784 Journal Article, 2015 DOI URL

Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992 Journal Article, 2015 DOI

Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260 Journal Article, 2015 DOI TARA - Full Text

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O'Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80 Journal Article, 2015 DOI TARA - Full Text

Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679 Journal Article, 2015 URL DOI

O'Neill L.A.J, A Broken Krebs Cycle in Macrophages, Immunity, 42, (3), 2015, p393 - 394 Journal Article, 2015 DOI URL

Kelly B, Tannahill G.M, Murphy M.P, O'Neill L.A.J, Metformin inhibits the production of reactive oxygen species from NADH: Ubiquinone oxidoreductase to limit induction of interleukin-1β (IL-1β) and boosts interleukin-10 (IL-10) in lipopolysaccharide (LPS)-activated macrophages, Journal of Biological Chemistry, 290, (33), 2015, p20348 - 20359 Journal Article, 2015 URL TARA - Full Text DOI

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA, Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1., Proceedings of the National Academy of Sciences of the United States of America, 112, (23), 2015, p7231-6 Journal Article, 2015 TARA - Full Text DOI

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 TARA - Full Text DOI

Norata G.D, Caligiuri G, Chavakis T, Matarese G, Netea M.G, Nicoletti A, O'Neill L.A.J, Marelli-Berg F.M, The Cellular and Molecular Basis of Translational Immunometabolism, Immunity, 43, (3), 2015, p421 - 434 Journal Article, 2015 URL DOI

Palsson-Mcdermott, E.M., Curtis, A.M., Goel, G., (...), Xavier, R.J., O'Neill, L.A.J. , Erratum: Pyruvate kinase m2 regulates hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in lps-activated macrophages (Cell Metabolism (2015) 21 (65-80)), 2015, - 347 Miscellaneous, 2015 DOI

Haneklaus M, O'Neill L.A.J, NLRP3 at the interface of metabolism and inflammation, Immunological Reviews, 265, (1), 2015, p53 - 62 Journal Article, 2015 DOI URL

Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257 Journal Article, 2015 URL DOI

Menon D, Coll R, O'Neill L.A.J, Board P.G, GSTO1-1 modulates metabolism in macrophages activated through the LPS and TLR4 pathway, Journal of Cell Science, 128, (10), 2015, p1982 - 1990 Journal Article, 2015 URL DOI

Finucane O.M, Lyons C.L, Murphy A.M, Reynolds C.M, Klinger R, Healy N.P, Cooke A.A, Coll R.C, Mcallan L, Nilaweera K.N, O'Reilly M.E, Tierney A.C, Morine M.J, Alcala-Diaz J.F, Lopez-Miranda J, O'Connor D.P, O'Neill L.A, Mcgillicuddy F.C, Roche H.M, Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity, Diabetes, 64, (6), 2015, p2116 - 2128 Journal Article, 2015 URL DOI

O'Neill, L.A.J., Glycolytic reprogramming by TLRs in dendritic cells, Nature Immunology, 15, (4), 2014, p314-315 Journal Article, 2014 DOI

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, Manjeri GR, Li Y, Ifrim DC, Arts RJ, van der Veer BM, van der Meer BM, Deen PM, Logie C, O'Neill LA, Willems P, van de Veerdonk FL, van der Meer JW, Ng A, Joosten LA, Wijmenga C, Stunnenberg HG, Xavier RJ, Netea MG, mTOR- and HIF-1"-mediated aerobic glycolysis as metabolic basis for trained immunity., Science (New York, N.Y.), 345, (6204), 2014, p1250684 Journal Article, 2014 DOI TARA - Full Text

Mockler MB, Conroy MJ, Lysaght J, Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment., Frontiers in oncology, 4, 2014, p107 Journal Article, 2014 TARA - Full Text DOI

Greenhill CJ, Jones GW, Nowell MA, Newton Z, Harvey AK, Moideen AN, Collins FL, Bloom AC, Coll RC, Robertson AA, Cooper MA, Rosas M, Taylor PR, O'Neill LA, Humphreys IR, Williams AS, Jones SA, Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction., Arthritis research & therapy, 16, (4), 2014, p419 Journal Article, 2014 DOI TARA - Full Text

Anne M. Curtis, Marina M. Bellet, Paolo Sassone-Corsi & Luke A.J. O'Neill , Circadian Clock Proteins and Immunity, Immunity, Volume 40, (2), 2014, 178-186 Journal Article, 2014 DOI TARA - Full Text

van den Bosch MW, Palsson-Mcdermott E, Johnson DS, O'Neill LA, LPS induces the degradation of programmed cell death protein 4 (PDCD4) to release Twist2, activating c-Maf transcription to promote interleukin-10 production., The Journal of biological chemistry, 289, (33), 2014, p22980-90 Journal Article, 2014 DOI TARA - Full Text

Galván-Peña S, O'Neill LA, Metabolic reprograming in macrophage polarization., Frontiers in immunology, 5, 2014, p420 Journal Article, 2014 TARA - Full Text DOI

Dowling JK, Becker CE, Bourke NM, Corr SC, Connolly DJ, Quinn SR, Pandolfi PP, Mansell A, O'Neill LA, Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation., The Journal of biological chemistry, 289, (10), 2014, p6429-37 Journal Article, 2014 TARA - Full Text DOI

d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ., The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer., PLoS One. , 9, (6), 2014, pe100816- Journal Article, 2014 DOI TARA - Full Text

Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA., The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10., The Journel of Biological Chemistry, 289, (9), 2014, p4316-4325 Journal Article, 2014 TARA - Full Text DOI

Quinn SR, Mangan NE, Caffrey BE, Gantier MP, Williams BR, Hertzog PJ, McCoy CE, O'Neill LA, The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10., The Journal of biological chemistry, 289, (7), 2014, p4316-25 Journal Article, 2014 TARA - Full Text DOI

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 DOI TARA - Full Text

Wochal, P., Rathinam, V.A.K., Dunne, A., (...), Fitzgerald, K.A., O'Neill, L.A.J. , TRIL is involved in cytokine production in the brain following escherichia coli infection, Journal of Immunology, 193, (4), 2014, p1911-1919 Journal Article, 2014 DOI TARA - Full Text

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 TARA - Full Text DOI

Connolly DJ, O'Neill LA, McGettrick AF, The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling., The Journal of biological chemistry, 288, (8), 2013, p5616-5623 Journal Article, 2013 TARA - Full Text DOI

Mcgettrick, A.F., O'Neill, L.A.J., NLRP3 and IL-1β in macrophages as critical regulators of metabolic diseases, Diabetes, Obesity and Metabolism , 15, (S3), 2013, p19-25 Journal Article, 2013 DOI TARA - Full Text

Dowling JK, McCoy CE, Doyle SL, Benlarbi N, Canavan M, O'Neill LA, Loscher CE, Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14., The Journal of nutritional biochemistry, 24, (5), 2013, p920-928 Journal Article, 2013 TARA - Full Text DOI

McGettrick, A.F., O'Neill, L.A.J., How metabolism generates signals during innate immunity and inflammation, Journal of Biological Chemistry, 288, (32), 2013, 22893-22898 Journal Article, 2013 DOI TARA - Full Text

Fagundes, C.T., O'Neill, L.A.J., Building unique bonds to fight misplaced DNA, Cell Research , 23, (9), 2013, p1065-1066 Journal Article, 2013 TARA - Full Text DOI

Haneklaus, M., Gerlic, M., O'Neill, L.A.J., Masters, S.L., miR-223: Infection, inflammation and cancer, Journal of Internal Medicine, 274, (3), 2013, p215-226 Journal Article, 2013 TARA - Full Text DOI

Palsson-Mcdermott, E.M., O'Neill, L.A.J., The Warburg effect then and now: From cancer to inflammatory diseases, BioEssays, 35, (11), 2013, p965-973 Journal Article, 2013 DOI TARA - Full Text

O'Neill LA, Hardie DG, Metabolism of inflammation limited by AMPK and pseudo-starvation., Nature, 493, (7432), 2013, p346-355 Journal Article, 2013 TARA - Full Text DOI

Adamik, J., Wang, K.Z.Q., Unlu, S., Su, A.-J.A., Tannahill, G.M., Galson, D.L., O'Neill, L.A., Auron, P.E., Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α, PLoS One, 8, (8), 2013, pe70622 Journal Article, 2013 DOI TARA - Full Text

Haneklaus M, O'Neill LA, Coll RC, Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments., Current opinion in immunology, 25, (1), 2013, p40-45 Journal Article, 2013 DOI TARA - Full Text

O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, (5), 2013, p610-2 Journal Article, 2013 DOI TARA - Full Text

Carpenter S, Aiello D, Atianand MK, Ricci EP, Gandhi P, Hall LL, Byron M, Monks B, Henry-Bezy M, Lawrence JB, O'Neill LA, Moore MJ, Caffrey DR, Fitzgerald KA, A long noncoding RNA mediates both activation and repression of immune response genes., Science (New York, N.Y.), 341, (6147), 2013, p789-92 Journal Article, 2013 TARA - Full Text DOI

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 TARA - Full Text DOI

O'Neill LA, Immunology. Sensing the dark side of DNA., Science (New York, N.Y.), 339, (6121), 2013, p763-764 Journal Article, 2013 TARA - Full Text DOI

Kenny, E.F., Quinn, S.R., Doyle, S.L., Vink, P.M., van Eenennaam, H., O'Neill, L.A.J., Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin, PLoS ONE, 8, (8), 2013, part. no. e74103 Journal Article, 2013 TARA - Full Text DOI

Mills, E., O'Neill, L.A.J., Succinate: a metabolic signal in inflammation, Trends in Cell Biology, 2013 Journal Article, 2013 TARA - Full Text DOI

O'Neill, L.A.J., Golenbock, D., Bowie, A.G., The history of Toll-like receptors-redefining innate immunity, Nature Reviews Immunology, 13, (6), 2013, p453-460 Journal Article, 2013 TARA - Full Text DOI

Bernard, N.J., O'Neill, L.A, Mal, more than a bridge to MyD88, IUBMB Life , 65, (9), 2013, p777-786 Journal Article, 2013 DOI TARA - Full Text

Miggin, S.M., Pålsson-McDermott, E., Dunne, A., Jefferies, C., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P., Yamamoto, M., Akira, S., Rothwell, N., Golenbock, D., Fitzgerald, K.A., O'Neill, L.A.J. , Erratum: NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1 (Proceedings of the National Academy of Sciences of the United States of America (2007) 110 (3372-3377) DOI: 10.1073/pnas.0608100104) (Erratum), 2013, - 17600 Miscellaneous, 2013 DOI

Doyle SL, Shirey KA, McGettrick AF, Kenny EF, Carpenter S, Caffrey BE, Gargan S, Quinn SR, Caamaño JH, Moynagh P, Vogel SN, O'Neill LA, Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15., J. Biol. Chem., 288, (35), 2013, p25066 - 25075 Journal Article, 2013 TARA - Full Text

Foley NH, O'Neill LA, miR-107: a toll-like receptor-regulated miRNA dysregulated in obesity and type II diabetes., Journal of leukocyte biology, 92, (3), 2012, p521-527 Journal Article, 2012 DOI

Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP, Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs., Circulation. Cardiovascular interventions, 5, (2), 2012, p279-287 Journal Article, 2012 DOI

Netea MG, Wijmenga C, O'Neill LA, Genetic variation in Toll-like receptors and disease susceptibility., Nature immunology, 13, (6), 2012, p535-542 Journal Article, 2012 DOI

Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P, NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components., Nature medicine, 18, (5), 2012, p791-798 Journal Article, 2012 DOI

Connolly DJ, O'Neill LA, New developments in Toll-like receptor targeted therapeutics., Current opinion in pharmacology, 12, (4), 2012, p510-518 Journal Article, 2012 DOI

Wen H, Ting JP, O'Neill LA, A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?, Nature immunology, 13, (4), 2012, p352-357 Journal Article, 2012 DOI

Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012 Journal Article, 2012 DOI TARA - Full Text

Haneklaus M, Gerlic M, Kurowska-Stolarska M, Rainey AA, Pich D, McInnes IB, Hammerschmidt W, O'Neill LA, Masters SL, Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1ß production., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p3795-9 Journal Article, 2012 DOI

O'Neill LA, "Transflammation": when innate immunity meets induced pluripotency., Cell, 151, (3), 2012, p471-3 Journal Article, 2012 DOI

Dowling JK, O'Neill LA, Biochemical regulation of the inflammasome., Critical reviews in biochemistry and molecular biology, 47, (5), 2012, p424-443 Journal Article, 2012 DOI

Ward SG, O'Neill LA, Spurs in the hunt for new immunomodulatory drug targets., Current opinion in pharmacology, 12, (4), 2012, p439-443 Journal Article, 2012 DOI

Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299 Journal Article, 2012 DOI TARA - Full Text

Doyle SL, Husebye H, Connolly DJ, Espevik T, O'Neill LA, McGettrick AF, The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation., Nature communications, 3, 2012, p707 Journal Article, 2012 DOI

Gillian M. Tannahill, Luke A.J. O'Neill, The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3, FEBS Letter, 585, (11), 2011, p1568-1572 Journal Article, 2011 TARA - Full Text

Ultaigh SN, Saber TP, McCormick J, Connolly M, Dellacasagrande J, Keogh B, McCormack W, Reilly M, O'Neill LA, McGuirk P, Fearon U, Veale DJ, Blockade of Toll-like receptor 2 prevents spontaneous cytokine release from rheumatoid arthritis ex vivo synovial explant cultures., Arthritis research & therapy, 13, (1), 2011, pR33 Journal Article, 2011 TARA - Full Text DOI

Coll RC, O'Neill LA., The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes, PLoS ONE, 6, (12, e29539), 2011 Journal Article, 2011 TARA - Full Text

Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA., Toll-like receptor 4 (TLR4) down-regulates microRNA-107 increasing macrophage adhesion via cyclin-dependent kinase 6, Journal of Biological Chemistry, 286, (29), 2011, p25531-9 Journal Article, 2011 URL DOI TARA - Full Text

Durrani O, Banahan K, Sheedy FJ, McBride L, Ben-Chetrit E, Greiner K, Vaughan RW, Kondeatis E, Hamburger J, Fortune F, Stanford MR, Murray PI, O'Neill LA, Wallace GR, TIRAP Ser180Leu polymorphism is associated with Behcet's disease., Rheumatology , 50, (10), 2011, p1760-5 Journal Article, 2011 DOI

Anthony Ryan, Mark Lynch, Sinead M. Smith, Sylvie Amu, Hendrik J. Nel, Claire E. McCoy, Jennifer K. Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J. O'Connell, Brian Keogh, Charles O. Morton, Thomas R. Rogers, Padraic G. Fallon, Luke A. O'Neill, Dermot Kelleher, Christine E. Loscher , A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins, PLoS Pathogens, 7, (6, e1002076), 2011 Journal Article, 2011 TARA - Full Text

Nathalie Court, Stéphanie Rose, Marie-Laure Bourigault, Sophie Front, Olivier R. Martin, Jennifer K. Dowling, Elaine F. Kenny, Luke O'Neill, François Erard, Valerie F. J. Quesniaux, Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms, PLoS ONE, 6, (9, e24631), 2011 Journal Article, 2011 TARA - Full Text

Carpenter S, Wochal P, Dunne A, O'Neill LA, Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL)., The Journal of Biological Chemistry, 286, (44), 2011, p38795-38804 Journal Article, 2011 TARA - Full Text DOI

O'Neill LA, Bowie AG, The powerstroke and camshaft of the RIG-I antiviral RNA detection machine., Cell, 147, (2), 2011, p259-261 Journal Article, 2011 DOI

Muhammad M. Alam and Luke A. O'Neill, MicroRNAs and the resolution phase of inflammation in macrophages, European Journal of Immunology, 41, (9), 2011, p2482-2485 Journal Article, 2011 TARA - Full Text

O'Neill LA, Counter-regulation in the IKK family., The Biochemical Journal, 434, (1), 2011, pe1-2 Journal Article, 2011 TARA - Full Text URL DOI

O'Neill LA, A critical role for citrate metabolism in LPS signalling., The Biochemical journal, 438, (3 ), 2011, pe5-6 Journal Article, 2011 DOI

Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904 Journal Article, 2010 DOI

Madden SF, Carpenter SB, Jeffery IB, Bjorkbacka H, Fitzgerald KA, O'Neill LA, Higgins DG, Detecting microRNA activity from gene expression data., BMC Bioinformatics, 11, (1), 2010, p257 Journal Article, 2010 DOI TARA - Full Text URL

Zhang, X., Shephard, F., Kim, H.B., Palmer, I.R., McHarg, S., Fowler, G.J.S., O'Neill, L.A.J., (...), Qwarnstrom, E.E., TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-κB, Journal of Biological Chemistry, 285, (10), 2010, p7222-7232 Journal Article, 2010 TARA - Full Text

McCoy CE, Sheedy FJ, Qualls JE, Doyle SL, Quinn SR, Murray PJ, O'Neill LA, IL-10 inhibits miR-155 induction by Toll-like receptors., The Journal of Biological Chemistry, 285, (27), 2010, p20492-20498 Journal Article, 2010 DOI TARA - Full Text URL

Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP., Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. , Circulation., 121, (1), 2010, p80-90 Journal Article, 2010 TARA - Full Text

Lavelle EC, Murphy C, O'Neill LA, Creagh EM, The role of TLRs, NLRs and RLRs in mucosal innate immunity and homeostasis , Mucosal Immunology, 3, (1), 2010, p17 - 28 Journal Article, 2010

O'Neill, L.A.J., Hennessy, E.J., Parker, A.E, Targeting Toll-like receptors: Emerging therapeutics?, Nature Reviews Drug Discovery, 9, (4), 2010, p293-307 Journal Article, 2010 DOI

O'Neill, L.A.J., Bowie, A.G., Sensing and Signaling in Antiviral Innate Immunity , Current Biology , 20, (7), 2010, pR328-R333 Journal Article, 2010 TARA - Full Text DOI

Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q, Johnson DS, Chen Y, O'Neill LA., Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21, Nature Immunology, 11, (2), 2010, p141-147 Journal Article, 2010 DOI

Coll, R.C., O'Neill, L.A.J., New insights into the regulation of signalling by toll-like receptors and nod-like receptors, Journal of Innate Immunity, 2, (5), 2010, p406-421 Journal Article, 2010 DOI

YanMei Liang, Jeremy Hetzel, Ansu Noronha, Daniel Onguru, Susan Carpenter, Melanie Mott, Sherman Biogornia, Caroline Apovian, Noyan Gokce, Jennifer Coukos, Dennis Kasper, Luke O'Neill, Pauline Mwinzi, Francis Farraye, Marie McDonnell, Lisa Ganley-Leal., Systemic Toll-like receptor ligands modify B cell responses in human chronic inflammatory disease., Journal of Clinical Investigation., 2010, p1-10 Journal Article, 2010 DOI

O'Neill, L.A.J, Stopping sepsis by targeting sphingosine kinase 1, Science Translational Medicine, 2, (36), 2010, p36ps29 Journal Article, 2010 DOI

McGettrick AF, O'Neill LA, Localisation and trafficking of Toll-like receptors: an important mode of regulation. , Current Opinion in Immunology, 22, (1), 2010, p20-27 Journal Article, 2010 DOI

Susan Carpenter, Aisling Dunne, Pearl Gray, Constantinos Brikos, Astrid Strelow, Holger Wesche, Nick Morrice and Luke A.J. O'Neill. , IRAK1 AND IRAK4 promote phosphorylation, Ubiquitination and degradation of MyD88 adapter-like (MAL)., Journal of Biological Chemistry, 285, (24), 2010, p18276-18282 Journal Article, 2010 DOI

Uncovering novel gene function in TLR signalling using siRNA in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Carty, M., Keating, S. & Bowie, A.G. ] Book Chapter, 2009

Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709 Journal Article, 2009 DOI

Sheedy FJ, O'Neill LA., Adding fuel to fire: microRNAs as a new class of mediators of inflammation., Annals of the Rheumatic Diseases, 67 , (Suppl 3), 2009, piii50 - iii55 Journal Article, 2009 DOI URL

Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357 Journal Article, 2009 DOI

McCormack WJ, Parker AE, O'Neill LA., Toll-like receptors and NOD-like receptors in rheumatic diseases., Arthritis Research & Therapy , 11, (5), 2009, p243 Journal Article, 2009 DOI

Sharp, F., Ruane, D., Claas, B., Creagh, E., Harris, J., Malyala, P., Singh, M., O'Hagan, D.T., Pétrilli, V., Tschopp, J., O'Neill, L.A.J. and *Lavelle, E.C, Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome., Proceedings of the National Academy of Sciences of the U.S.A, 106, (3), 2009, p870-875 Journal Article, 2009 DOI TARA - Full Text

Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995 Journal Article, 2009 DOI

Palsson-McDermott E, Doyle S, McGettrick A, Hardy M, Husebye H, Banahan K, Gong M, Golenbock , Espevik T and O'Neill LAJ, TAG: a GOLD domain-containing splice variant of TRAM that negatively regulates the MyD88-independent pathway in TLR4 signaling, Nature Immunology, 10, 2009, p579 - 586 Journal Article, 2009 DOI

Carpenter S, O'Neill LA , Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins., Biochemistry Journal, 422, (1), 2009, p1-10 Journal Article, 2009 DOI

Characterisation of viral proteins that inhibit TLR signal transduction in, editor(s)O'Neill, L.A.J and McCoy, C. , Toll-Like Receptors, Methods of Molecular Biology, Humana Press, 2009, [Stack, J & Bowie, A.G.] Book Chapter, 2009

O'Neill LA, Bryant CE, Doyle SL, Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer., Pharmacological Reviews, 61, (2), 2009, p177-97 Journal Article, 2009 DOI

O'Neill LAJ and McCoy C, Toll-like receptor protocols. Methods in Molecular Medicine Series, 517, New Jersey USA , Humana Press, 2009 Book, 2009

O'Neill LA, Boosting the brain's ability to block inflammation via microRNA-132., Immunity, 31, (6), 2009, p854-855 Journal Article, 2009 DOI

Becker CE, Creagh EM, O'Neill LA, Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion, Journal of Biological Chemistry, 284, (50), 2009, p34531-34537 Journal Article, 2009 DOI TARA - Full Text

Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG., Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock, Proceedings of the National Academy of Science USA, 106, (25), 2009, p10272-10277 Journal Article, 2009 DOI

O'Neill LA, A feed-forward loop involving hyaluronic acid and toll-like receptor-4 as a treatment for colitis?, Gastroenterology., 137, (6), 2009, p1889-1891 Journal Article, 2009 DOI

O'Neill, L.A.J., O'Farrelly, C., The immune system as an invisible, silent Grand Fugue, Nature Immunology, 10, (10), 2009, p1043-1045 Journal Article, 2009 DOI

O'Neill LA, Regulation of signaling by non-degradative ubiquitination., The Journal of Biological Chemistry, 284, (13), 2009, p8209 Journal Article, 2009 URL DOI

O'Neill LA., DNA makes RNA makes innate immunity, Cell, 138, (3), 2009, p428-430 Journal Article, 2009 DOI

Sheedy FJ, Marinou I, O'Neill LA, Wilson AG., The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to or severity of rheumatoid arthritis., Ann Rheum Dis., 2008 Journal Article, 2008 URL DOI

O'Neill LAJ , When signalling pathways collide: positive and negative regulation of Toll-like receptor signalling, Immunity , 29, (1), 2008, p12 - 20 Journal Article, 2008 DOI URL

O'Neill LA, The interleukin-1 receptor / Toll-like receptor superfamily: ten years of progress, Immunological Reviews, 226, (1), 2008, p10 - 18 Journal Article, 2008 DOI URL

Brikos C, O'Neill LA. , Signalling of toll-like receptors., Handb Exp Pharmacol., 183, 2008, p21-50 Review, 2008

McCoy CE, Carpenter S, Palsson-McDermott EM, Gearing J, O'Neill, LA, Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like, The Journal of Biological Chemistry, 283, 2008, p14277-14285 Journal Article, 2008 TARA - Full Text DOI

McCoy CE, O'Neill LA., The role of toll-like receptors in macrophages., Front Biosci., 1, (13), 2008, p62-70 Journal Article, 2008 DOI URL

O'Neill LAJ, Immunology. How frustration leads to inflammation., Science, 320, (5876), 2008, p619-20 Journal Article, 2008 DOI URL

O'Neill LA , Primer: Toll-like receptor signaling pathways--what do rheumatologists need to know?, Nat Clin Pract Rheumatol., 4, (6), 2008, p319-27 Journal Article, 2008 DOI

O'Neill L.A., Bacteria fight back against Toll-like receptors., Nat Med., 14, (4), 2008, p370-372 Journal Article, 2008 DOI URL

Kenny EF, O'Neill LA., Signalling adaptors used by Toll-like receptors: an update., Cytokine, 43, (3), 2008, p342 - 349 Journal Article, 2008 DOI URL

Chau TL, Gioia R, Gatot JS, Patrascu F, Carpentier I, Chapelle JP, O'Neill L, Beyaert R, Piette J, Chariot A, Are the IKKs and IKK-related kinases TBK1 and IKK-varepsilon similarly activated?, Trends Biochem Sci, 33, (4), 2008, p171-80 Journal Article, 2008 DOI URL

O'Neill LA, 'Fine tuning' TLR signaling, Nat Immunol. , 9, (5), 2008, p459-61 Journal Article, 2008 DOI URL

O'Neill, L.A., Innate Immunity: Squelching Anti-Viral Signalling with NLRXI, Curr Biol, 18, (7), 2008, pR302-R304 Journal Article, 2008 URL DOI

Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969 Journal Article, 2008 DOI URL

Piao W, Song C, Chen H, Wahl LM, Fitzgerald KA, O'Neill LA, Medvedev AE., Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance, Journal of Biological Chemistry, 283, (6), 2008, p3109-19 Journal Article, 2008 DOI TARA - Full Text

Becker CE, O'Neill LA., Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs., Semin Immunopathol. , 29, (3), 2007, p239-48. Journal Article, 2007 URL DOI

Wietek C, O'Neill LA., Diversity and regulation in the NF-kappaB system., Trends Biochem Sci., 32, (7), 2007, p311-319. Journal Article, 2007 DOI URL

O'Neill LA., TAMpering with toll-like receptor signaling., Cell, 131, (6), 2007, p1039-41 Journal Article, 2007 URL DOI

O'Neill LA and Bowie AG, The family of five: TIR domain containing adapters in TLR signalling, Nat Rev Immunol, 7, 2007, p353-364 Journal Article, 2007 URL DOI

Palsson-McDermott EM, O'Neill LA. , The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60 Review, 2007 URL DOI

McGettrick AF, O'Neill LA., Toll-like receptors: key activatory of leucocytes and regulator of haematopoiesis, Br J Haematol., 139, (2), 2007, p185-93 Journal Article, 2007 URL DOI

Khor, CC, Chapman, SJ, Vannberg, FO, Dunne A, Murphy C, Ling EY, Frodsham AJ, Walley, A, Kyrieleis, O, Khan, A, Aucan, C, Segal, S, Moore, CE, Know, K, Campbell, SJ, Lienhardt, C, Scott, A, Aaby, P, Sow, OY, Grignani, RT, Peshu, N, Williams, TN, Maitland, K, Davies, RJO, Kwiatkowski, DP, Day, NP, Yala, D, Crook, DW, Marsh, K, Berkley, JA, O'Neill LAJ* and Hill, AVS*, A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis, Nature Genetics, 39, (4), 2007, p523 - 528 Journal Article, 2007 DOI TARA - Full Text

Doyle SL, Jefferies CA, Feighery C, O'Neill LA., Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase., Journal of Biological Chemistry, 282, (51), 2007, p36953-36960. Journal Article, 2007 TARA - Full Text DOI

Watters TM, Kenny EF, O'Neill, LA., Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins., Immunol Cell Biol., 85, (6), 2007, p411-419. Journal Article, 2007 URL DOI

Sheedy F. and O'Neill L.A., The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling, Journal of Leukocyte Biology, 82, (2), 2007, p196-203 Journal Article, 2007 TARA - Full Text DOI

Nuñez Miguel R, Wong J, Westolll JF, Brooks HJ, O'Neill LA, Gay NJ, Bryant, A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins., PLoS ONE, 2, (8), 2007, pe788. Journal Article, 2007 TARA - Full Text DOI URL

Pålsson-McDermott EM, O'Neill LA., The potential of targeting Toll-like receptor 2 in autoimmune and inflammatory diseases, Ir J Med Sci, 176, (4), 2007, p253-60 Journal Article, 2007 URL DOI

Carpenter S, O'Neill LA., How important are Toll-like receptors for antimicrobial responses?, Cell Microbiology, 9, (8), 2007, p1891-1901. Journal Article, 2007 URL DOI

Miggin SM, Palsson-McDermott E, Dunne A, Jefferies, CA, Pinteaux, E, Banahan, K, Murphy C, Moynagh PN, Yamamoto, S, Akira S, Rothwell N, Golenbock, DT, Fitzgerald KA and O'Neill LA, NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1, Proceedings of the National Academy of Sciences , 104, 2007, p3372 - 3377 Journal Article, 2007 DOI TARA - Full Text

Constantinos Brikos, Robin Wait, Shajna Begum, Luke A. J. O'Neill, and Jeremy Saklatvala,, Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components, Molecular and Cellular Proteomics, 6, 2007, p1551-1559 Journal Article, 2007 DOI TARA - Full Text

Palsson-McDermott EM, O'Neill, LA. , Building an immune system from nine domains., Biochem Soc Trans., 35, (6), 2007, p1437-44 Review, 2007 URL

Gubster C, Goodbody R, Ecker A, Brady G, O'Neill LA, Jacobs N, Smith GL., Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus, Journal of General Virology, 88, (6), 2007, p1667-1676 Journal Article, 2007 DOI TARA - Full Text

McGettrick, A, Brint EK, Palsson-McDermott, EM, Rowe, DC, Golenbock, DT, Gay NJ, Fitzgerald, KA and O'Neill LA, Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling, Proceedings of the National Academy of Sciences , 103, (24), 2006, p9196 - 9201 Journal Article, 2006 TARA - Full Text DOI

Mansell, A, Simth, R, Doyle S, Gray P, Fennen JE, Crack P, Nicholson S, Hilton DJ, O'Neill LA* and Hertzog P* , Suppressor of cytokine signaling (SOCS)-1 negatively regulates Toll-like receptor signaling by targeting Mal for degradation, Nature Immunol., 7, (2), 2006, p148 - 155 Journal Article, 2006 URL DOI

O'Neill LA, Targetting signal transduction pathways as a strategy for anti-inflammatory drugs, Nature Reviews Drug Discovery, 2006 Journal Article, 2006

O'Neill LA, How Toll-like receptors signal: what we know and what we don't know, Current Opinion in Immunology, 18, (1), 2006, p3 - 9 Journal Article, 2006 URL DOI

O'Neill LA, DisSARMing Toll-like receptor signaling, Nat Immunol., 7, (10), 2006, p1023 - 1025 Journal Article, 2006 URL DOI

Miggin SM and O'Neill LA, New insights into the regulation of TLR signaling, Journal of Leukocyte Biology, 80, (2), 2006, p220 - 226 Journal Article, 2006 DOI TARA - Full Text

Creagh E and O'Neill LAJ, TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity, Trends Immunol., 27, (8), 2006, p352 - 357 Journal Article, 2006 URL DOI

O'Neill LA, Targeting signal transduction as a strategy to treat inflammatory diseases, Nature Rev. Drug Disc, 5, (7), 2006, p549 - 563 Journal Article, 2006 URL DOI

Mansell A, Toynbee J, Gray P, Doyle S, Hilton D, O'Neill LA and Hertzog P, Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation , Nature Immunology, 7, (2), 2006, p148 - 155 Journal Article, 2006 DOI URL

Pearl Gray, Aisling Dunne, Constantinos Brikos, Caroline A. Jefferies, Sarah L. Doyle, and Luke A. J. O'Neill, MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction, Journal of Biological Chemistry, 281, (15), 2006, p10489 - 10495 Journal Article, 2006 DOI TARA - Full Text

Doyle, SL and O'Neill LAJ, Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity, Biochem Pharmacol., 72, (9), 2006, p1102 - 1113 Journal Article, 2006 URL DOI

Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'neill LA, Perretti M, Rossi AG, Wallace JL, Resolution of inflammation: state of the art, definitions and terms, The FASEB Journal, 21, (2), 2006, p325 - 332 Journal Article, 2006 DOI TARA - Full Text

Wietek,C, Cleaver, CS, Ludbrook, V, Wilde, J, White, J, Bell, DJ, Lee, M, Dickson, M, Ray, KP and O'Neill, LAJ, IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65, The Journal of Biological Chemistry, 281, (46), 2006, p34973 - 34981 Journal Article, 2006 TARA - Full Text DOI

Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT, The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction, Proceedings of the National Academy of Sciences , 103, (16), 2006, p6299 - 6304 Journal Article, 2006 TARA - Full Text DOI

O'Neill LA , Immunity's early warning system, Scientific American , 292, (1), 2005, p38 - 45 Journal Article, 2005 URL

Liew, E, Xu, D, Brint, E, O'Neill, LA, Negative regulation of TLR signalling, Nature Rev. Immunol., 5, (6), 2005, p446 - 458 Journal Article, 2005 DOI URL

Panayi, G and O'Neill LA, Targetting innate and adaptive immunity in arthritis, New England Jounral of Medicine, 2005 Journal Article, 2005

O'NEILL LA et al, PCT application - 'Assays relating to Toll-like receptor-4 and compositions for modulating same', 2005 Patent, 2005

Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, Journal of Biological Chemistry, 280, (25), 2005, p23496 - 23501 Journal Article, 2005 DOI

Brady G, Boggan L, Bowie A and O'Neill LA, Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1, Journal of Biological Chemistry, 280, (35), 2005, p30723 - 30734 Journal Article, 2005 TARA - Full Text DOI

Dunne A and O'Neill LA, Adaptor usage and Toll-like receptor signaling specificity, FEBS Lett., 579, (15), 2005 Review, 2005 URL DOI

O'Neill LA, TLRs play good cop bad cop in lung, Nature Medicine, 11, (11), 2005, p1161 - 1162 Journal Article, 2005 URL DOI

Doyle S, Jefferies CA and O'Neill LA, Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS, J Biol Chem., 280, (25), 2005, p23496 - 23501 Journal Article, 2005 TARA - Full Text URL DOI

Dunne A and O'Neill L, New insights into the post-translational modification of Toll-like receptor, Journal of Endotoxin Research, 11, (6), 2005, p325 - 332 Journal Article, 2005 URL DOI

O'Toole D, Abde;-Latif AM, Long A, Windle HJ, Murphy AM, Bowie A, O'Neill LA, Weir DG, Kelleher D, Low pH and Helicobacter pylori increase nuclear factor kappa B binding in gastric epithelial cells: a common pathway for epithelial cell injury?, Journal of Cellular Biochemistry, 96, (3), 2005, p589 - 588 Journal Article, 2005 URL DOI

O'NEILL LA et al, PCT application: 'TLR14 - a novel Toll-like receptor', 2005 Patent, 2005

Luke O'Neill and Elisabeth Brint (editors), Toll-like receptors in inflammation, Plenum Press, 2005 Book, 2005

Hardy MP, McGettrick AF, O'Neill LAJ, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, Biochemical Journal, 380, (1), 2004, p83 - 93 Journal Article, 2004 URL

Khan JA, Brint EK, O'Neill LAJ, Tong L, Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL, Journal of Biological Chemistry, 279, (30), 2004, p31664 - 31670 Journal Article, 2004 TARA - Full Text DOI

Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'Neill LAJ, Qwarnstrom EE, Dower SK, Human tribbles, a protein family controlling mitogen-activated protein kinase cascades, Journal of Biological Chemistry, 279, (41), 2004, p42703 - 42708 Journal Article, 2004 DOI TARA - Full Text

E. K. Brint, D. Xu, H. Liu, A. Dunne, A. N. McKenzie, L. A. O'Neill and F. Y. Liew, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, Nature immunology, 5, (4), 2004, p373-379 Journal Article, 2004 URL DOI URL

O'NEILL LUKE A J (Trinity College Dublin); SIMS JOHN E (Immunex); BIRD TIMOTHY A (Immunex), MyD88 adaptor-like proteins, 2004, WO 01/088137 Patent, 2004

A. F. McGettrick and L. A. O'Neill, The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction, Mol Immunol, 41, (6-7), 2004, p577-82 Journal Article, 2004 DOI URL

Mansell, A, Brint E, Gould, JA, O'Neill, LA and Hertzog, P, Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4, Journal of Biological Chemistry, 279, (36), 2004, p37227 - 37230 Journal Article, 2004 DOI TARA - Full Text

C. A. Jefferies and L. A. O'Neill, Bruton's tyrosine kinase (Btk)-the critical tyrosine kinase in LPS signalling?, Immunology letters, 92, (38018), 2004, p15-22 Journal Article, 2004 URL DOI

E. M. Palsson-McDermott and L. A. O'Neill, Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4, Immunology, 113, (2), 2004, p153-62 Journal Article, 2004 DOI TARA - Full Text

L. A. O'Neill, Immunology. After the toll rush, Science, 303, (5663), 2004, p1481-2 Journal Article, 2004 DOI URL

L. A. O'Neill, How NOD-ing off leads to Crohn disease, Nature immunology, 5, (8), 2004, p776-8 Journal Article, 2004 DOI URL

Hardy, M, McGettrick, A and O'Neill, LAJ , Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene., Biochemical Journal, 380, (1), 2004, p83 - 93 Journal Article, 2004 TARA - Full Text DOI

O'Neill LA, Toll-like receptors: Professor Metchnikov, sit on your hat, Trends in Immunol, 125, (12), 2004, p687 - 693 Journal Article, 2004 URL DOI

Brint EK, Xu DM, Liu HY, Dunne A, McKenzie ANJ, O'Neill LAJ, Liew FY, ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance, NATURE IMMUNOLOGY, 5, (4), 2004, p373 - 379 Journal Article, 2004 DOI URL

M. P. Hardy and L. A. O'Neill, The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory, The Journal of biological chemistry, 279, (26), 2004, p27699-708 Journal Article, 2004 TARA - Full Text DOI

M. P. Hardy, G. A. F. Mc and L. A. O'Neill, Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene, The Biochemical journal, 380, (Pt 1), 2004, p83-93 Journal Article, 2004 URL

O'NEILL LA et al., PCT application - "A52R - Orthopoxvirus, genes and products thereof", 2003 Patent, 2003

E. F. Dunn, N. J. Gay, A. F. Bristow, D. P. Gearing, L. A. O'Neill and X. Y. Pei, High-resolution structure of murine interleukin 1 homologue IL-1F5 reveals unique loop conformations for receptor binding specificity, Biochemistry, 42, (37), 2003, p10938-10944 Journal Article, 2003 URL URL DOI

A. Dunne, M. Ejdeback, P. L. Ludidi, L. A. O'Neill and N. J. Gay, Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88, The Journal of Biological Chemistry, 278, (42), 2003, p41443-41451 Journal Article, 2003 TARA - Full Text DOI

L. A. O'Neill, K. A. Fitzgerald and A. G. Bowie, The Toll-IL-1 receptor adaptor family grows to five members, Trends in immunology, 24, (6), 2003, p286-90 Journal Article, 2003 URL DOI URL

L. A. O'Neill, SIGIRR puts the brakes on Toll-like receptors., Nature immunology, 4, (9), 2003, p823-824 Journal Article, 2003 DOI URL URL

P. J. Hertzog, L. A. O'Neill and J. A. Hamilton, The interferon in TLR signaling: more than just antiviral, Trends in Immunology, 24, (10), 2003, p534-539 Journal Article, 2003 URL URL DOI

O'Neill LA , Antisense modulation of TLR-4 expression, Expert Opinion on Therapeutic Patents, 13, (12), 2003, p1887 - 1889 Journal Article, 2003 URL DOI

A. Dunne and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2003, (171), 2003, pre3 Review, 2003 DOI URL URL

L. A. O'Neill, A. Dunne, M. Edjeback, P. Gray, C. Jefferies and C. Wietek, Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors, Journal of Endotoxin Research, 9, (1), 2003, p55-9 Journal Article, 2003 URL DOI URL

C. A. Jefferies, S. Doyle, C. Brunner, A. Dunne, E. Brint, C. Wietek, E. Walch, T. Wirth and L. A. O'Neill, Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4, The Journal of Biological Chemistry, 278, (28), 2003, p26258-64 Journal Article, 2003 DOI TARA - Full Text URL

S. G. Ward and L. A. O'Neill, Spotlight on new anti-inflammatory drug targets in the immune system, Current opinion in pharmacology, 3, (4), 2003, p391-5 Journal Article, 2003 URL URL DOI

C. Wietek, S. M. Miggin, C. A. Jefferies and L. A. O'Neill, Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa, The Journal of Biological Chemistry, 278, (51), 2003, p50923-50931 Journal Article, 2003 DOI TARA - Full Text

L. A. O'Neill, Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases, Current opinion in pharmacology, 3, (4), 2003, p396-403 Journal Article, 2003 URL URL DOI

L. A. O'Neill, The role of MyD88-like adapters in Toll-like receptor signal transduction, Biochemical Society Transactions, 31, (Pt 3), 2003, p643-637 Journal Article, 2003 URL

O'NEILL LA et al., PCT application - "A46R - Orthopoxvirus, genes and products thereof"., 2003 Patent, 2003

L. A. O'Neill, Z. Brown and S. G. Ward, Toll-like receptors in the spotlight, Nature immunology, 4, (4), 2003, p299 Journal Article, 2003 DOI URL URL

Harte, MT, Haga, I, Maloney, G, Gray, P, Reading, PC, Bartlett, N, Smith, GL, Bowie, AG and O'Neill, LAJ , The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defence, Journal of Experimental Medicine, 197, (3), 2003, p343 - 351 Journal Article, 2003 TARA - Full Text DOI

L. A. O'Neill, Signal transduction pathways activated by the IL-1 receptor/toll-like receptor superfamily, Current Topics in Microbiology and Immunology, 270, 2002, p47-61 Journal Article, 2002 URL URL

E. P. McDermott and L. A. O'Neill, Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1, The Journal of Biological Chemistry, 277, (10), 2002, p7808-7815 Journal Article, 2002 TARA - Full Text DOI URL

Brint, E.K., Fitzgerald, K.A., Smith, P., Coyle, A.J., Gutierrez-Ramos, J-C., Fallon, P.G. & O'Neill, L.A.J., Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction, Journal of Biological Chemistry, 277, (51), 2002, p49205 - 49211 Journal Article, 2002 TARA - Full Text DOI

V. Corrigall and L. A. O'Neill, Using immunotherapy to treat rheumatic diseases, Trends in immunology, 23, (8), 2002, p383-384 Journal Article, 2002 URL URL DOI

L. A. O'Neill, Wanted: a molecular basis for specificity in toll-like receptor signal transduction, Molecular cell, 10, (5), 2002, p969-971 Journal Article, 2002 URL URL DOI

Wietek, C and O'Neill, LAJ , IRAK-4: a new drug target in inflammation, sepsis and autoimmunity, Molecular Interventions, 2, (4), 2002, p212 - 215 Journal Article, 2002 URL TARA - Full Text

L. A. O'Neill, Toll-like receptor signal transduction and the tailoring of innate immunity: a role for Mal?, Trends in immunology, 23, (6), 2002, p296-300 Journal Article, 2002 URL URL DOI

O'Neill, LAJ, Toll-like receptors and the danger hypothesis, Trends in Immunology, 22, (8), 2001, p421 Journal Article, 2001 URL DOI URL

O'Neill, L.A.J, Gob genes, mucus and asthma. , Trends in Immunology, 22, (7), 2001, p353 Journal Article, 2001 URL DOI

O'Neill, L.A.J, Vaccine safety concerns, Trends in Immunology, 22, (8), 2001, p420 - 421 Journal Article, 2001 URL DOI

E. Dunn, J. E. Sims, M. J. Nicklin and L. A. O'Neill, Annotating genes with potential roles in the immune system: six new members of the IL-1 family, Trends in Immunology, 22, (10), 2001, p533-536 Journal Article, 2001 URL DOI URL

O'Neill, L.A.J, Co-stimulating allergy, Trends in Immunology, 22, (4), 2001, p183 Journal Article, 2001 URL DOI

O'Neill, L.A.J, A role for leptin in autoimmunity, Trends in Pharmacological Sciences, 22, (7), 2001, p341 Journal Article, 2001 DOI URL

O'Neill, L.A.J, Crohn's disease gene is given the NOD, Trends in Immunology, 22, (8), 2001, p418 - 419 Journal Article, 2001 URL DOI

L. O'Neill, Specificity in the innate response: pathogen recognition by Toll-like receptor combinations, Trends in immunology, 22, (2), 2001, p70 Journal Article, 2001 URL DOI URL

A. Mansell, A. Reinicke, D. M. Worrall and L. A. O'Neill, The serine protease inhibitor antithrombin III inhibits LPS-mediated NF-kappaB activation by TLR-4, FEBS letters, 508, (3), 2001, p313-317 Journal Article, 2001 URL DOI URL

O'Neill, L.A.J, A role for leptin in autoimmunity? , Trends in Immunology, 22, (7), 2001, p352 Journal Article, 2001 URL DOI

A. Mansell, N. Khelef, P. Cossart and L. A. O'Neill, Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt, The Journal of Biological Chemistry, 276, (47), 2001, p43597-43603 Journal Article, 2001 TARA - Full Text DOI

Commins S, O'Neill LA, O'Mara SM., The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., Neuroscience, 102, (2), 2001, p273 - 280 Journal Article, 2001 URL DOI

O'Neill, L.A.J, An AIDS vaccine in sight? , Trends in Immunology, 22, (5), 2001, p242 Journal Article, 2001 DOI URL

O'Neill, L.A.J, A roll-call of monocytic gene induction, Trends in Immunology, 22, (4), 2001, p182 Journal Article, 2001 DOI URL

O'Neill, L.A.J, Irish say no to Nice but yes to immunology, Trends in Immunology, 22, (8), 2001, p421 Journal Article, 2001 DOI URL

O'Neill, L.A.J. and Bowie, A.G. (editors) , Interleukin Protocols, New Jersey, USA, Methods in Molecular Medicine Series, Humana Press, 2001, 443pp Book, 2001

C. Jefferies, A. Bowie, G. Brady, E. L. Cooke, X. Li and L. A. O'Neill, Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1, Molecular and Cellular Biology, 21, (14), 2001, p4544-4552 Journal Article, 2001 DOI

K. A. Fitzgerald, E. M. Palsson-McDermott, A. G. Bowie, C. A. Jefferies, A. S. Mansell, G. Brady, E. Brint, A. Dunne, P. Gray, M. T. Harte, D. McMurray, D. E. Smith, J. E. Sims, T. A. Bird and L. A. O'Neill, Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction, Nature, 413, (6851), 2001, p78-83 Journal Article, 2001 URL DOI URL

BRINT, B, T1/ST2 SIGNAL TRANSDUCTION: ACTIVATION OF AP-1, JNK, P38 AND P42/P44 MAP KINASE BUT NOT NF-KAPPAB, unknown, 2001, ISI Web of Science, 2001, pp58 - 58 Meeting Abstract, 2001

O'Neill, L.A.J, IL-1 versus TNF in arthritis?. , Trends in Immunology, 22, (7), 2001, p353-354 Journal Article, 2001 DOI URL

O'Neill, L.A.J, A vaccine for colorectral cancer, Trends in Immunology, 22, (7), 2001, p354 Journal Article, 2001 URL DOI

FITZGERALD, KA, MAL (MYD88 ADAPTER-LIKE) IS REQUIRED FOR TOLL-LIKE RECEPTOR-4 SIGNAL TRANSDUCTION, unknown, 2001, ISI Web of Science, 2001, pp33 - 33 Meeting Abstract, 2001

Kelly Á, Lynch A. Vereker E, Nolan Y, Queenan P, Whittaker E, O' Neill LAJ, Lynch MA. , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Journal Article, 2001 TARA - Full Text DOI

O'Neill, LAJ, Fitzgerald, K, Gearing, AJH and Callard, R, Cytokine Factsbook, 2nd, London, U.K, Academic Press, 2001, 513pp Book, 2001

O'Neill, L.A.J, A gene for Crohn's disease is given the nod, Trends in Pharmacological Sciences, 22, (8), 2001, p398 - 399 Journal Article, 2001 URL DOI

B. White, M. Schmidt, C. Murphy, W. Livingstone, D. O'Toole, M. Lawler, L. O'Neill, D. Kelleher, H. P. Schwarz and O. P. Smith, Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line, British Journal of Haematology, 110, (1), 2000, p130-134 Journal Article, 2000 DOI URL URL

L. O'Neill, The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence, Biochemical Society Transactions, 28, (5), 2000, p557-563 Journal Article, 2000 URL URL

A. Bowie, E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower and L. A. O'Neill, A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling, Proceedings of the National Academy of Sciences of the United States of America, 97, (18), 2000, p10162-10167 Journal Article, 2000 TARA - Full Text URL DOI

L. A. O'Neill and C. A. Dinarello, The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense, Immunology today, 21, (5), 2000, p206-209 Journal Article, 2000 URL URL DOI

L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense, Science's STKE [electronic resource], 2000, (44), 2000, pRE1 Journal Article, 2000 URL DOI URL

M. P. Boland, K. A. Fitzgerald and L. A. O'Neill, Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells, The Journal of Biological Chemistry, 275, (33), 2000, p25231-25238 Journal Article, 2000 TARA - Full Text DOI

Omara, SM, O'Neill LAJ, The effects of the bacterial endotoxin lipopolysaccharide on synaptic transmission and plasticity in the CA1-subiculum pathway in vivo., unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250 Meeting Abstract, 2000

K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology, 164, (4), 2000, p2053-2063 Journal Article, 2000

D. R. Caffrey, L. A. O'Neill and D. C. Shields, A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways, Protein Science, 9, (4), 2000, p655-670 Journal Article, 2000 URL TARA - Full Text

A. Mansell, L. Braun, P. Cossart and L. A. O'Neill, A novel function of InIB from Listeria monocytogenes: activation of NF-kappaB in J774 macrophages, Cellular microbiology, 2, (2), 2000, p127-136 Journal Article, 2000 DOI URL URL

E. M. Palsson, M. Popoff, M. Thelestam and L. A. O'Neill, Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1, The Journal of Biological Chemistry, 275, (11), 2000, p7818-7825 Journal Article, 2000 URL TARA - Full Text

C. A. Jefferies and L. A. O'Neill, Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression, The Journal of Biological Chemistry, 275, (5), 2000, p3114-3120 Journal Article, 2000 TARA - Full Text URL

E. J. Ryan, E. McNeela, M. Pizza, R. Rappuoli, L. O'Neill and K. H. Mills, Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity, Journal of Immunology (Baltimore, Md, 165, (10), 2000, p5750-9 Journal Article, 2000 TARA - Full Text URL URL

K. A. Fitzgerald and L. A. O'Neill, The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence, Microbes and infection / Institut Pasteur, 2, (8), 2000, p933-943 Journal Article, 2000 URL URL DOI

A. G. Bowie and L. A. O'Neill, Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase, Journal of Immunology, 165, (12), 2000, p7180-7188 Journal Article, 2000 TARA - Full Text URL

The IL1 receptor / Toll-like receptor superfamily in, editor(s)J Oppenheim and M Feldmann , The Cytokine Reference, Academic Press, 2000, pp1565 - 1586, [O'Neill, LAJ and Dower, SJ ] Book Chapter, 2000

J. M. O'Sullivan, A. Gribbin, J. Taylor, L. O'Neill, S. Cosgrove and J. G. Armstrong, Complications of treatment with local field external beam radiotherapy for localized prostate cancer, Clinical Oncology (Royal College of Radiologists (Great Britain)), 12, (4), 2000, p217-221 Journal Article, 2000

A. Bowie and L. A. O'Neill, Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries, Biochemical pharmacology, 59, (1), 2000, p13-23 Journal Article, 2000 URL DOI URL

A. Bowie and L. A. O'Neill, The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products, Journal of Leukocyte Biology, 67, (4), 2000, p508-514 Journal Article, 2000 TARA - Full Text URL

K. A. Fitzgerald, A. G. Bowie, B. S. Skeffington and L. A. O'Neill, Ras, protein kinase C zeta, and I kappa B kinases 1 and 2 are downstream effectors of CD44 during the activation of NF-kappa B by hyaluronic acid fragments in T-24 carcinoma cells, Journal of Immunology , 164, (4), 2000, p2053-2063 Journal Article, 2000 URL

D. R. Caffrey, L. A. O'Neill and D. C. Shields, The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades, Journal of Molecular Evolution, 49, (5), 1999, p567-582 Journal Article, 1999 URL URL DOI

C. Greene and L. O'Neill, Interleukin-1 receptor-associated kinase and TRAF-6 mediate the transcriptional regulation of interleukin-2 by interleukin-1 via NFkappaB but unlike interleukin-1 are unable to stabilise interleukin-2 mRNA, Biochimica et biophysica acta, 1451, (1), 1999, p109-121 Journal Article, 1999 URL DOI URL

K. A. Fitzgerald and L. A. O'Neill, Characterization of CD44 induction by IL-1: a critical role for Egr-1, Journal of Immunology , 162, (8), 1999, p4920-4927 Journal Article, 1999 URL TARA - Full Text

A. N. Coogan, L. A. O'Neill and J. J. O'Connor, The P38 mitogen-activated protein kinase inhibitor SB203580 antagonizes the inhibitory effects of interleukin-1beta on long-term potentiation in the rat dentate gyrus in vitro, Neuroscience, 93, (1), 1999, p57-69 Journal Article, 1999 URL DOI URL

Bowie A, O'Neill LA., Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries., Biochemical Pharmacology, 59, (1), 1999, p13 - 23 Journal Article, 1999 DOI URL

J. S. Matthews and L. A. O'Neill, Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1, Cytokine, 11, (9), 1999, p643-655 Journal Article, 1999 URL URL DOI

FITZGERALD, K, INTERLEUKIN-1 UPREGULATES EXPRESSION OF METASTASIS-ASSOCIATED VARIANT V6 IN THE HUMAN ENDOTHELIAL CELL LINE ECV304 BY A MECHANISM INVOLVING THE TRANSCRIPTION FACTOR EGR-1., unknown, 1998, 78, ISI Web of Science, 1998, pp16 - 16 Meeting Abstract, 1998

PALSSON, EM, INHIBITION OF P38 AND P42/P44 MAPK BY CLOSTRIDIUM SORDELLII LETHAL TOXIN IN IL-1 STIMULATED T LYMPHOCYTES - A ROLE FOR A RAS SUBFAMILY G PROTEIN IN IL-1 SIGNALLING, unknown, 1998, 9, ISI Web of Science, 1998, pp457 - 457 Meeting Abstract, 1998

M. P. Boland and L. A. O'Neill, Ceramide activates NFkappaB by inducing the processing of p105, The Journal of Biological Chemistry, 273, (25), 1998, p15494-15500 Journal Article, 1998 TARA - Full Text DOI URL

Brennan P, O'Neill LA., Inhibition of nuclear factor kappaB by direct modification in whole cells--mechanism of action of nordihydroguaiaritic acid, curcumin and thiol modifiers., Biochemical Pharmacology, 55, (7), 1998, p965 - 973 Journal Article, 1998 DOI URL

O'Neill LA, Greene C., Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants., Journal of Leukocyte Biology , 63, (6), 1998, p650 - 657 Journal Article, 1998 TARA - Full Text URL

McGowan AJ, Bowie AG, O'Neill LA, Cotter TG., The production of a reactive oxygen intermediate during the induction of apoptosis by cytotoxic insult., Experimental Cell Research, 238, (1), 1998, p248 - 256 Journal Article, 1998 URL DOI

BOLAND, MP, TOPOISOMERASE II IS A TARGET FOR ANTHRACYCLINE-MEDIATED ACTIVATION OF NF KAPPA B, unknown, 1998, 78, ISI Web of Science, 1998, pp9 - 9 Meeting Abstract, 1998

O'Neill LA, Matthews JS, Pålsson E, Jeffries C, Brennan P, Cantrell DA., Interleukin 1 signalling: synergy with Rac1 and Pi3 kinase., Biochemical Society Transactions, 25, (4), 1998, pS578 - S578 Journal Article, 1998

O'Neill, LA, Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture., Biochemical Society Transactions, 25, (1), 1997, p295 - 302 Journal Article, 1997

Brennan P, O'Neill LA., 2-mercaptoethanol restores the ability of nuclear factor kappa B (NF kappa B) to bind DNA in nuclear extracts from interleukin 1-treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF kappa B by PDTC., Biochemical Journal, 320, (3), 1997, p975 - 981 Journal Article, 1997 URL

A. G. Bowie, P. N. Moynagh and L. A. O'Neill, Lipid peroxidation is involved in the activation of NF-kappaB by tumor necrosis factor but not interleukin-1 in the human endothelial cell line ECV304. Lack of involvement of H2O2 in NF-kappaB activation by either cytokine in both primary and transformed endothelial cells, The Journal of biological chemistry, 272, (41), 1997, p25941-25950 Journal Article, 1997 URL

M. A. O'Connell, D. Kelleher, R. M. Liskamp, N. Hall, L. A. O'Neill and A. Long, TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes, Cytokine, 9, (2), 1997, p83-92 Journal Article, 1997 URL URL DOI

Coogan, A, O'Neill, LAJ, The p38 MAP kinase inhibitor SB203580 antagonizes the inhibitory effect of interleukin-1β on long-term potentiation in the rat dentate gyrus in vitro, unknown, 1997, 501P, ISI Web of Science, 1997, ppP86 - P87 Meeting Abstract, 1997

O'Connell MA, Kelleher D, Liskamp RM, Hall N, O'Neill LA, Long A., TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes., Cytokine, 9, (2), 1997, p83 - 92 Journal Article, 1997 DOI URL

M. P. Boland, S. J. Foster and L. A. O'Neill, Daunorubicin activates NFkappaB and induces kappaB-dependent gene expression in HL-60 promyelocytic and Jurkat T lymphoma cells, The Journal of Biological Chemistry, 272, (20), 1997, p12952-12960 Journal Article, 1997 DOI TARA - Full Text URL

O'Neill LA, Kaltschmidt C., NF-kappa B: a crucial transcription factor for glial and neuronal cell function., Trends in Neurosciences, 20, (6), 1997, p252 - 258 Journal Article, 1997 DOI URL

Fitzgerald K, O'Neill LA., Induction of the adhesion molecule CD44 by the pro-inflammatory cytokine interleukin-1 in endothelial cells., Biochemical Society Transactions, 25, (2), 1997, pS185 - S185 Journal Article, 1997

Mahon TM, Matthews JS, O'Neill LA., Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells., Biochemical Journal, 325, (1), 1997, p39 - 45 Journal Article, 1997 TARA - Full Text URL

Mahon TM, O'Neill LA., Investigation into the role of protein kinase C in IL1 and PMA signalling in EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS81 - S81 Journal Article, 1996

Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20 Journal Article, 1996 DOI URL

O'Neill LA, Kelly VP., Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma., Biochemical Society Transactions, 23, (4), 1996, pS597 - S597 Journal Article, 1996

M. P. Boland, S. J. Foster and L. A. O'Neill, Activation of NF kappa B and potentiation of TNF-induced NF kappa B activation by ceramide analogues in leukemic cell lines despite the absence of an observed sphingomyelinase signalling event, Biochemical Society Transactions, 24, (1), 1996, p1S Journal Article, 1996 URL

MATTHEWS, JS, P38 ACTIVATION AS A KEY EVENT IN THE INDUCTION OF IL2 BY IL1 IN T LYMPHOCYTES, unknown, 1996, 89, ISI Web of Science, 1996, ppAA398 - AA398 Meeting Abstract, 1996

MATTHEWS, JS, THE EFFECT OF MAPKK INHIBITOR PD98059, THE P38MAPK INHIBITOR SB203580 AND THE SMALL G PROTEIN RAC 1 ON INTERLEUKIN 1 SIGNAL TRANSDUCTION IN T LYMPHOCYTES, unknown, 1996, 119, ISI Web of Science, 1996, ppP12 - P12 Meeting Abstract, 1996

O'Neill, LAJ, Interleukin-1 signal transduction., Ineternational Journal of Clinical & Laboratory Research, 25, (4), 1996 Review, 1996

McCarthy LM, O'Neill LA., Effect of pertussis toxin and PGE2 on the functioning of the IL-2 promoter in interleukin-1 treated EL4.NOB-1 thymoma cells., Biochemical Society Transactions, 24, (1), 1996, pS82 - S82 Journal Article, 1996

Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20 Journal Article, 1996 URL DOI

Brennan P, O'Neill LA., Inhibition of NF kappa B activity by oxidative processes in intact cells mechanism of action of pyrolidine dithiocarbamate and diamide., Biochemical Society Transactions, 24, (1), 1996, pS3 - S3 Journal Article, 1996

O'Neill, LAJ, Interleukin I receptors and signal transduction., Biochemical Society Transactions, 24, (1), 1996, p207 - 211 Journal Article, 1996

Dunican DJ, Griffiths R, Williams DC, O'Neill LA., Endothelin-1 increases arachidonic acid release in C6 glioma cells through a potassium-modulated influx of calcium., Journal of Neurochemistry, 67, (2), 1996, p830 - 837 Journal Article, 1996

FITZGERALD, K, INDUCTION OF THE ADHESION MOLECULE CD44 BY THE PRO-INFLAMMATORY CYTOKINE INTERLEUKIN-1 IN ENDOTHELIAL CELLS, unknown, 1996, 89, ISI Web of Science, 1996, ppF69 - F69 Meeting Abstract, 1996

Mahon TM, O'Neill LA., Evidence for direct modification of NF kappa B by the tyrosine kinase inhibitor, herbimycin A., Biochemical Society Transactions, 23, (1), 1995, pS111 - S111 Journal Article, 1995

Murphy, M and O'Neill, LAJ (eds), What is Life? The next 50 years, Cambridge, UK, Cambridge University Press, 1995 Book, 1995

M. A. O'Connell, R. Cleere, A. Long, L. A. O'Neill and D. Kelleher, Cellular proliferation and activation of NF kappa B are induced by autocrine production of tumor necrosis factor alpha in the human T lymphoma line HuT 78, The Journal of biological chemistry, 270, (13), 1995, p7399-404 Journal Article, 1995 URL DOI TARA - Full Text

McCarthy LM, O'Neill LAJ, Effects of pertussis toxin and its binding subunit on IL-1 signaling in T-cells, Biochemical Society Transactions, 23, (1), 1995, pS112 - S112 Journal Article, 1995

Hassan J, O'Neill S, O'Neill LA, Pattison U, Reen DJ., Signalling via CD28 of human naive neonatal T lymphocytes., Clinical and Experimental Immunology, 102, (1), 1995, p192 - 198 Journal Article, 1995 URL TARA - Full Text

DUNICAN, DJ, GRIFFITHS, R, ONEILL, LAJ, WILLIAMS, DC, DEPOLARIZING LEVELS OF KCI INHIBIT ENDOTHELIN-1-MEDIATED RELEASE OF ARACHIDONIC-ACID IN RAT C6 GLIOMA-CELLS, Biochemical Society Transactions, 23, (1), 1995, pS285 - S285 Journal Article, 1995

Maria A. O'Connell, Roisin Cleere , Aideen Long , Luke A. J. O'Neill , Dermot Kelleher , Cellular Proliferation and Activation of NFB Are Induced by Autocrine Production of Tumor Necrosis Factor in the Human T Lymphoma Line HuT 78 , Journal of Biological Chemistry, 270, (13), 1995, p7399 - 7404 Journal Article, 1995 URL

Mahon TM, O'Neill LA., Studies into the effect of the tyrosine kinase inhibitor herbimycin A on NF-kappa B activation in T lymphocytes. Evidence for covalent modification of the p50 subunit., Journal of Biological Chemistry, 270, (48), 1995, p28557 - 28564 Journal Article, 1995 TARA - Full Text DOI URL

CUNNINGHAM, A, INHIBITION OF LONG-TERM POTENTIATION BY TUMOR-NECROSIS-FACTOR IN THE RAT DENTATE GYRUS IN-VITRO, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P6 Meeting Abstract, 1995

Cleere R, Long A, Kelleher D, O'Neill LA., Autocrine regulation of the transcription factor NF kappa B by TNF alpha in the human T cell lymphoma line Hut 78., Biochemical Society Transactions, 23, (1), 1995, pS113 - S113 Journal Article, 1995

Brennan P, O'Neill LA., Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals., Biochimica et Biophysica Acta (BBA) -Gene Structure and expression, 1260, (2), 1995, p167 - 175 Journal Article, 1995 DOI URL

O'Neill, LAJ, Towards an understanding of the signal transduction pathways for interleukin 1., Biochimica et Biophysica Acta (BBA) , 1266, (1), 1995 Review, 1995

Kelly VP and O'Neill LA, Sustained activation of NF kappa B and transient I kappa B alpha degradation induced by tumour necrosis factor in 1321N1 human astrocytoma, Biochemical Society Transactions, 23, (4), 1995, p597S - 597S Journal Article, 1995

Moynagh PN, Williams DC, O'Neill LA., Activation of NF-kappa B and induction of vascular cell adhesion molecule-1 and intracellular adhesion molecule-1 expression in human glial cells by IL-1. Modulation by antioxidants., Journal of Immunology, 153, (6), 1994, p2681 - 2690 Journal Article, 1994 URL

O'Neill, LAJ, Murphy, M and Gallagher, RB , What are we? Where did we come from? Where are we going?, Science , 263, (5144), 1994, p181 - 183 Journal Article, 1994 URL DOI

P. N. Moynagh, D. C. Williams and L. A. O'Neill, Interleukin-1 activates transcription factor NF kappa B in glial cells, The Biochemical Journal, 294 , (2), 1993, p343-347 Journal Article, 1993 URL TARA - Full Text

Moynagh PN, O'Neill LA, Williams DC., Interleukin-1 and phorbol myristate acetate modulate the peripheral-type benzodiazepine receptor in lymphocytes and glial cells., Biochemical Pharmacology, 46, (5), 1993, p821 - 827 Journal Article, 1993 DOI URL

O'Neill, LAJ , Interleukin 1, a central mediator of inflammation, Journal of Biomedical Science, 3, 1992, p7 - 12 Journal Article, 1992

O'Neill, LAJ, Ikebe, T, SJ Sarsfield and Saklatvala, J, , The binding sub-unit of pertussis toxin inhibits IL1 induction of IL2 and prostaglandin production, Journal of Immunology, 148, (2), 1992, p474 - 479 Journal Article, 1992 URL

Luke A J O'Neill, How does interleukin-1 activate cells?, Kidney International , 41, 1992, p546 - 549 Journal Article, 1992 DOI URL

Stylianou E, O'Neill LA, Rawlinson L, Edbrooke MR, Woo P, Saklatvala J., Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes., Journla of Biological Chemistry, 267, (22), 1992, p15836 - 15841 Journal Article, 1992 TARA - Full Text URL

O'Neill, LAJ, Bird, TA, Gearing, AJH and Saklatvala, J, Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). , J Biol Chem , 265, (6), 1990, p3146 - 3152 Journal Article, 1990 URL

Laben JK, Legal issues related to the right to die: implications for nursing education., Deans Notes, 12, (2), 1990, p1-2 Journal Article, 1990

Saklatvala, J, Bird, TA, Kaur, P and O'Neill, LAJ , IL1 signal transduction: evidence of activation of G protein and protein kinase, Progress in Clinical Biological Research, 349, 1990, p285 - 295 Journal Article, 1990

O'Neill, LAJ, Bird, TA and Saklatvala, J, Interleukin 1 signal transduction, Immunol Today , 11, 1990, p392 - 394 Journal Article, 1990 URL DOI

O'Neill, LAJ and Lewis, GP, Interleukin-1 potentiates bradykinin- and TNF- induced PGE2 release, European Journal of Pharmacology, 166, (2), 1989, p131 - 137 Journal Article, 1989 DOI URL

O'Neill, LAJ and Lewis, GP, Inhibitory effects of diclofenac and indomethacin on interleukin-1-induced PGE2 release: a novel effect on free arachidonic acid levels in human synovial cells, Biochem Pharmacol , 38, (21), 1989, p3707 - 3711 Journal Article, 1989

O'Neill, LAJ, Barratt, ML and Lewis, GP, Extracts of feverfew inhibit mitogen-induced human peripheral blood mononuclear cell proliferation and cytokine mediated responses: a cytotoxic effect, British Journal of Clinical Pharmacology, 23, (1), 1987, p81 - 83 Journal Article, 1987 URL TARA - Full Text

O'Neill, LAJ, Barratt, ML and Lewis, GP, Induction of cyclooxygenase by interleukin-1 in rheumatoid synovial cells., FEBS Letts , 212, (1), 1987, p35 - 39 Journal Article, 1987 URL DOI

Non-Peer-Reviewed Publications

O'Neill, LAJ (Chair) and organising committee, International Cytokine Society meeting, September, 2003, TCD Meetings /Conferences Organised, 2003

O'Neill, LAJ (Chair) and organising committee , Biochemical Society meeting, 2001, TCD Meetings /Conferences Organised, 2001

Bowie, A. and O'Neill, L.A.J., Vitamin C inhibits NF kappa B activation in endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp131S. Conference Paper, 1997

Bowie, A. and O'Neill, L.A.J., Studies into the mechanism of NF kappa B activation by IL1, TNF and H2O2 in primary and transformed endothelial cells., Biochemistry Society Transactions, 25, (1), 1997, pp125S Conference Paper, 1997

A. Bowie, P. N. Moynagh and L. A. O'Neill, Mechanism of NF kappa B activation by interleukin-1 and tumour necrosis factor in endothelial cells, 24, (1), 1996, pp2S Conference Paper, 1996 URL URL

A. Bowie, P. N. Moynagh and L. A. O'Neill, The human endothelial cell line ECY304 as a model of endothelial cell activation by interleukin-1, 23, (1), 1995, pp109S Conference Paper, 1995 URL URL

Murphy, M and O'Neill, LAJ , 'What is Life? The Next 50 years', 1993 Meetings /Conferences Organised, 1993

Brennan, P., Bowie, A. and O'Neill, L.A.J., The Effect of Thiol Modifiers on the Activation of NF kappa B by Interleukin-1., 21, (4), 1993, pp390S Conference Paper, 1993

Hughes, O'Neill, Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling, Proceedings of the National Academy of Sciences of the United States of America Journal Article, TARA - Full Text URL URL URL

Research Expertise

Description

CURRENT RESEARCH: Research Area: Molecular and Cellular basis to inflammation and innate immunity. Toll-like receptors. Pro-inflammatory cytokines. Signal transduction in the immune system. Molecular analysis of inflammatory and infectious diseases. Inflammasomes. Immunometabolism.

Projects

  • Title
    • Control of TLRs and NLRs by microRNAs
  • Funding Agency
    • SFI
  • Title
    • Role of Nlrp3 in Type 2 diabetes
  • Title
    • . Novel proteins in the TLR and NLR systems
  • Title
    • Role of metabolism in innate immunity
  • Title
    • Circadian control of innate immunity

Keywords

3-DIMENSIONAL STRUCTURE; ACCEPTOR; ACIDIC SPHINGOMYELINASE; ACTIN-BASED MOVEMENT; ACTIVATED PROTEIN-KINASE; ACTIVATION; ACTIVATION PATHWAY; ADHESION MOLECULE; ADHESION MOLECULE-1; ALPHA; ANTIGEN; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ATHEROSCLEROTIC LESION; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis); BACTERIAL LIPOPOLYSACCHARIDE; BLOOD MONONUCLEAR-CELLS; C-JUN; CALCIUM CURRENTS; CALCIUM INFLUX; CASCADE; CATALYTIC ACTIVITY; CD18; CELL-FREE SYSTEM; CELLS; CELLULAR STRESSES; CERAMIDE; CHEMOKINE GENE-EXPRESSION; CHROMOSOMAL LOCATION; CLOSTRIDIUM-DIFFICILE; COMPLEX FACTOR ELK-1; CORD BLOOD; CRYSTAL-STRUCTURE; CUTTING EDGE; CYCLIC-AMP; CYTOKINES; DAUNORUBICIN-INDUCED APOPTOSIS; DENTATE GYRUS; DEPENDENT GENE-EXPRESSION; DEPENDENT MECHANISM; DEPENDENT TRANSCRIPTION; DIACYLGLYCEROL PRODUCTION; DISEASE; DISULFIDE; DNA-BINDING; DNA-BINDING ACTIVITY; DNA-BINDING SUBUNIT; DORSOVENTRAL POLARITY; DROSOPHILA; E-CADHERIN; EFFECTOR PATHWAYS; ENDOTHELIAL-CELL LINE; ENDOTHELIAL-CELLS; ENDOTOXIN; EXPRESSION; FACTOR INCREASE PHOSPHORYLATION; FACTOR-ALPHA; FACTOR-KAPPA-B; FAMILY; FAS-LIGAND; FIBROBLASTS; FUNCTIONAL-RESPONSES; GENE; GENE-EXPRESSION; Genetics; GROWTH-FACTOR-BETA; GTP-BINDING; GTP-BINDING PROTEINS; HIPPOCAMPAL SLICE; HIPPOCAMPAL SLICES; HIPPOCAMPAL-NEURONS; HIPPOCAMPUS; HL-60 CELLS; HL-60 LEUKEMIA-CELLS; HOST-DEFENSE; HUMAN-ENDOTHELIAL-CELLS; HUMAN-IMMUNODEFICIENCY-VIRUS; IDENTIFICATION; IL-1; IL-1 RECEPTOR; IL-1, Toll Receptors, NF-KappaB; IL-1/MAP KINASES; IL-2 MESSENGER-RNA; IL1HY1; Immune System; Immunomodulatory molecules as therapy for inflammatory or immune-mediated diseasesPro-inflammatory cytokines, Interleukin-1, Toll-like receptors, Toll-IL-1 receptor domain, Lipopolysaccharide; IN-VITRO; INDUCED APOPTOSIS; Inflammation; INHIBITORS; INTACT-CELLS; INTERLEUKIN-1; INTERLEUKIN-1 BETA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; INTERLEUKIN-1 RECEPTORS; INTERLEUKIN-1-BETA; INTERLEUKIN-2; INTERLEUKIN-2 PROMOTER; INTERNALIN MULTIGENE FAMILY; KAPPA-B; KAPPA-B ACTIVATION; KINASE; LETHAL TOXIN; LEUKOCYTE ADHESION MOLECULES; LINE ECV304; LIPOPOLYSACCARIDE; LIPOPOLYSACCHARIDE; LONG-TERM POTENTIATION; Long-term potentiation & signal transduction mechanisms including MAP kinases; MAMMALIAN-CELLS; MAP KINASE; MECHANISMS; Medicines; MESSENGER-RNA; MESSENGERS; Molecular basis to inflammation and innate immunity; MOLECULE CD28; MONOCYTE; MULTIPLE-SCLEROSIS; MURINE MACROPHAGES; MUTATIONS; NECROSIS-FACTOR-ALPHA; NEONATAL T CELLS; NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; ORGANIZATION; P50 SUBUNIT; PATHWAY; Pharmacology; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHOINOSITIDE 3-KINASE; PHOSPHORYLATION; PROTEINS; RECEPTOR; RECEPTOR ANTAGONIST BINDS; RECEPTOR CD44; RECEPTOR SUPERFAMILY; RECOGNITION; RICH REPEAT REGION; SIGNAL TRANSDUCTION; Signal transduction in the immune system, NF-kappaB, T1/ST2, MAP kinases; SIGNAL-TRANSDUCTION; SIGNAL-TRANSDUCTION PATHWAYS; SUBSTRATE-SPECIFICITY; SUPERFAMILY; SUPEROXIDE; SURFACE PROTEIN; T LYMPHOCYTES; T-CELL ACTIVATION; T-LYMPHOCYTE ACTIVATION; TERM POTENTIATION; TRANSCRIPTION FACTOR; TRANSDUCTION; TUMOR-NECROSIS-FACTOR

Recognition

Representations

External examiner for 40 PhD theses to date (Universities of Cambridge, London, Bath, Sheffield, Manchester, Liege, St. Andrews, Ulster, Melbourne, Sienna, University College Dublin, University College Cork, Queen's University Belfast).

External examiner for degree programme in Molecular Medicine, University of Wales

Section Editor for Journal of Leukocyte Biology

Chair of EU delegation to NSF/EU joint committee on Biotechnology of host defence

Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.

Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.

Member, Hepatitis C Focus Group Meeting, Focus group of investigators with Hepatitis C related research interests.Suggested themes : Immunogenomics of Hepatitis C or more broad theme

Member, Cycle 2 PI's & Researchers, All Cycle 2 Researchers & PI's

Member of the editorial boards of the Journal of Immunology (Section Editor), Trends in Immunology, Journal of Biological Chemistry, British Journal of Pharmacology and Cytokine

Member of board of external assessors for medical research at the Universities of Ghent and Melbourne (chairman of the latter)

Ad Hoc Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA

Ad Hoc Member of Cell and Molecular Immunology A Study Section, National Institutes of Health, USA

Member of Medical Research Council Advisory Board, UK

Member Avenir Committee INSERM, French National Insitute of Health

Member, Science Foundation Ireland Biotechnology Advisory Board

Chair, Scientific Advisory Board, Australian Co-operative Research Centre for Chronic Inflammatory Diseases

Member of the Pre-clinical committee, Irish Medicines Board

Member, Royal Irish Academy Life Sciences Committee

Member, Arthritis Foundation of Ireland academic advisory committee

Awards and Honours

Irish Society for Immunology Medal for Immunology 2004

Elected Member of the Royal Irish Academy 2004

Dublin Institute of Molecular Medicine Medal Lecture 2004

Charnock Bradley Award Lecture, University of Edinburgh 2004

Elected President, Biomedical Sciences Section, British Association for the Advancement of Science 2004

Elected Councillor, International Cytokine Society 2003

Dolph Adams Award, Society for Leukocyte Biology USA 2003

Shortlisted for the Boyle Medal, Royal Dublin Society 2002

Short-listed for the Boyle Medal, Royal Dublin Society 1999

Young Investigator Award, International Cytokine Society 1997

Royal Irish Academy Medal for Biochemistry 1996

Fellow, Trinity College Dublin 1996

Conway Medal for Biomedical Research by the Royal Academy of Medicine in Ireland 1995

Elected member of European Molecular Biology Organisation (EMBO) 2005

Appointed Chair of the European Research Council Infection and Immunity Panel 2008

Appointed Councillor of the International Cytokine Society(and rising to President in 2012) 2008

Immunology 'Guru', National Institutes of Health 2009

Advisor to the 2009 Nobel Committee for Physiology or Medicine 2009

Royal Dublin Society / Irish Times Boyle Medal for Scientific Excellence 2009

Science Foundation Ireland Researcher of the Year Award 2009

McGill University Dan Perry Award Lecture 2010

University of Oxford Jenner Institute Distinguished Lecturer 2010

President, International Cytokine Society 2012

Royal Irish Academy Gold Medal for Life Sciences 2012

European Federation of Immunology Societies Medal 2014

Visiting Fellow, Christ's College Cambridge 2016

Fellow of the Royal Society (FRS) 2016

International Cytokine and Interferon Society Milstein Award 2018

Queen's University Belfast Barcroft Medal 2018

Nobel Assembly, Karolinska Institute Research Lecture 2018

Austrian Academy of Sciences Landsteiner Award 2019

Memberships

International Cytokine Society (Councillor)

Biochemical Society

American Society for Biochemistry and Molecular Biology

Member Royal Irish Academy Life Sciences Committee

Member of the Pre-clinical committee, Irish Medicines Board

Member of MRC Advisory Board, UK

Member of Bacteriology and Mycology-2 Study Section, National Institutes of Health, USA