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Dr. Tomas Ryan
Associate Professor, Biochemistry
Associate Professor, Trinity Inst. of Neurosciences (TCIN)

Publications and Further Research Outputs

Peer-Reviewed Publications

Pignatelli, M. and Ryan, T.J. and Roy, D.S. and Lovett, C. and Smith, L.M. and Muralidhar, S. and Tonegawa, S., Engram Cell Excitability State Determines the Efficacy of Memory Retrieval, Neuron, 101, (2), 2019, p274-284.e5 Journal Article, 2019 DOI

Ortega-de San Luis, C. and Ryan, T.J., United states of amnesia: rescuing memory loss from diverse conditions, Disease models & mechanisms, 11, (5), 2018 Journal Article, 2018 DOI

McKay, S. and Ryan, T.J. and McQueen, J. and Indersmitten, T. and Marwick, K.F.M. and Hasel, P. and Kopanitsa, M.V. and Baxter, P.S. and Martel, M.-A. and Kind, P.C. and Wyllie, D.J.A. and O'Dell, T.J. and Grant, S.G.N. and Hardingham, G.E. and Komiyama, N.H., The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences, Cell Reports, 25, (4), 2018, p841-851.e4 Journal Article, 2018 DOI

De San Luis, C.O. and Ryan, T.J., United States of amnesia: rescuing memory loss from diverse conditions, DMM Disease Models and Mechanisms, 11, (5), 2018 Journal Article, 2018 DOI

McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Hardingham GE, Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1., eLife, 2017 Journal Article, 2017

Queenan BN, Ryan TJ, Gazzaniga MS, Gallistel CR, On the research of time past: the hunt for the substrate of memory., Annals of the New York Academy of Sciences, 2017 Journal Article, 2017

Ryan TJ, Tonegawa S., Rehebbilitating Memory., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 41, (1), 2016, p370-371 Journal Article, 2016 DOI

Roy DS, Arons A, Mitchell TI, Pignatelli M, Ryan TJ, Tonegawa S., Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease., Nature, 531, (7595), 2016, p508-512 Journal Article, 2016 DOI

Ryan, T.J. and Tonegawa, S., Erratum: Rehebbilitating Memory (Neuropsychopharmacology (2016) 41 (370-371) DOI: 10.1038/npp.2015.264), Neuropsychopharmacology, 41, (5), 2016, p1437 Journal Article, 2016 DOI

Frank RA, Komiyama NH, Ryan TJ, Zhu F, O'Dell TJ, Grant SG., NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation., Nature communications, 7, 2016, p11264 Journal Article, 2016 DOI

Poo MM, Pignatelli M, Ryan TJ, Tonegawa S, Bonhoeffer T, Martin KC, Rudenko A, Tsai LH, Tsien RW, Fishell G, Mullins C, Gonçalves JT, Shtrahman M, Johnston ST, Gage FH, Dan Y, Long J, Buzsáki G, Stevens C., What is memory? The present state of the engram., BMC biology, 14, 2016, p40 Journal Article, 2016 DOI

Ryan, T.J. and Roy, D.S. and Pignatelli, M. and Arons, A. and Tonegawa, S., Engram cells retain memory under retrograde amnesia, Science, 348, (6238), 2015, p1007-1013 Journal Article, 2015 DOI

Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S., Memory. Engram cells retain memory under retrograde amnesia., Science (New York, N.Y.), 348, (6238), 2015, p1007-1013 Journal Article, 2015 DOI

Tonegawa S, Pignatelli M, Roy DS, Ryan TJ., Memory engram storage and retrieval., Current opinion in neurobiology, 35, 2015, p101-109 Journal Article, 2015 DOI

Ryan, T.J., Kopanitsa, M.V., Indersmitten, T., Nithianantharajah, J., Afinowi, N.O., Pettit, C., Stanford, L.E., Sprengel, R., Saksida, L.M., Bussey, T.J., O'Dell, T.J., Grant, S.G.N., Komiyama, N.H., Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior, 16, (1), 2013, p25-32 Journal Article, 2013

Ryan, T.J. and Kopanitsa, M.V. and Indersmitten, T. and Nithianantharajah, J. and Afinowi, N.O. and Pettit, C. and Stanford, L.E. and Sprengel, R. and Saksida, L.M. and Bussey, T.J. and O'dell, T.J. and Grant, S.G.N. and Komiyama, N.H., Erratum: Evolution of GluN2A/B cytoplasmic domains diversified vertebrate synaptic plasticity and behavior (Nature Neuroscience (2013) 16 (25-32)), Nature Neuroscience, 16, (12), 2013, p1908 Journal Article, 2013 DOI

Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R.L., Ryan, T.J., Tonegawa, S., Creating a false memory in the hippocampus, 341, (6144), 2013, p387-391 Journal Article, 2013

Martel, M.-A., Ryan, T., Bell, K., Fowler, J., McMahon, A., Al-Mubarak, B., Komiyama, N., Horsburgh, K., Kind, P., Grant, S., Wyllie, D., Hardingham, G., The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults, 74, (3), 2012, p543-556 Journal Article, 2012

Ryan, T.J. and Grant, S.G.N., Erratum: The origin and evolution of synapses (Nature Reviews Neuroscience (2009) 10 (701-712)), Nature Reviews Neuroscience, 10, (11), 2009, p829 Journal Article, 2009 DOI

Ryan, T.J., Grant, S.G.N., The origin and evolution of synapses, 10, (10), 2009, p701-712 Journal Article, 2009

Ryan, T.J., Emes, R.D., Grant, S.G.N., Komiyama, N.H., Evolution of NMDA receptor cytoplasmic interaction domains: Implications for organisation of synaptic signalling complexes, 9, 2008 Journal Article, 2008

Research Expertise

Keywords

ENGRAM; Evolution; MEMORY

Recognition

Awards and Honours

European Research Council (ERC) Staring Grant January 2017

Science Foundation Ireland - President of Ireland Young Researcher Award (PIYRA) November 2016

Jacobs Foundation Research Fellowship January 2017

National Health & Medical Research Council (NHMRC) Project Grant June 2018

Junior Research Fellowship, Wolfson College, University of Cambridge, UK September 2009

Wellcome Trust PhD Studentship (4 years) October 2005

Memberships

Society for Neuroscience (USA) October 2006 – Present