Dr. Dominic Trepel
Assistant Professor, Psychiatry
Assistant Professor, Trinity Inst. of Neurosciences (TCIN)
Biography
Dominic Trépel (PhD) joined Trinity in 2017 as an Assistant Professor of Economics and is jointly appointed as faculty for the Global Brain Health Institute (www.gbhi.org) and Trinity School of Medicine. Trépel is also primary investigator in Trinity College Institute of Neuroscience (TCIN) where he directs Trépel lab (www.healtheconomics.ie). Trépel has been an academic health economics for over 15 years, has published over 100 research articles and much of this research efforts are dedicated to the study of dementia, brain health and ageing. Trépel lab currently includes ten PhDs and Postdoctoral researchers working on grants funded by: Health Research Board (HRB), Irish Research Council (Ireland), Research Collaborative in Quality and Patient Safety (RCQPS), Health and Social Care Northern Ireland (R&D Division), Global Brain Health Institute, Brainlat and National Health and Medical Research Council (NHMRC).
Trépel has previously held Senior Research Fellowships with leading centres in health economics including University of York and the Academic Unit for Health Economics (AUHE) at University of Leeds. His PhD examined the 'Economics of Dementia in Ireland and Europe' was supported by the prestigious Government of Ireland Scholarship (IRCHSS) and a Cochrane Fellowship (HRB), and outputs were presented to members of the Irish Parliament.
Trépel is a member of the International Health Economics Association (iHEA), and the Campbell and Cochrane Economics Methods Group (CCEMG). He was part of the scientific committee for the joint meeting of the Coèllge des Economistes de la Santé (CES) and the Health Economists' Study Group (HESG). He also serves on the Editorial Board for Alzheimer's and Dementia Journal, is an associate editor for Frontiers in Health Services and further peer-reviews research for, amongst others the Health Economics Journal, Social Science in Medicine, National Institute for Health Research (NIHR) Library. Trépel has also reviewed research funding applications for NIHR, Medical Research Council (MRC), GBHI Pilot program, US Alzheimer's Association and the EU Joint Programme " Neurodegenerative Disease Research (JPND). Trépel also serves on the management committee of "Dementia Research Network Ireland".
Through his international doctoral training in health economics (from the Swiss School of Public Health (SSPH+)) and from working in a number of leading research centres, Trepél offers a broad technical skillset which includes: Applied Microeconometrics, Statistical Analysis, Health Service Research, Research Design, Economic Evaluation, Cost-Effectiveness Analysis, Health Technology Assessment, Randomised Control Trials, Decision-Analytic Modelling, Health Financing, Analysis of Health Expenditures, Critical Appraisal of Decision Models, Evidence Based Medicine, Systematic Review, Meta-analysis, Medical Decision Making, Outcomes Research, Reimbursement Mechanisms and Productivity Analysis.
Publications and Further Research Outputs
Peer-Reviewed Publications
Conneely, M and Holmes, A and O'Connor, M and Leahy, A and Gabr, A and Saleh, A and Okpaje, B and Corey, G and Barry, L and Griffin, A and others, 265 A PHYSIOTHERAPY-LED TRANSITION TO HOME INTERVENTION FOR OLDER ADULTS FOLLOWING EMERGENCY DEPARTMENT DISCHARGE: A PILOT FEASIBILITY RANDOMISED-CONTROLLED TRIAL, Age and Ageing, 51, (Supplement_3), 2022, pafac218--233
Conneely, Mairead, Leahy, Aoife, O'Connor, Margaret, Barry, Louise, Corey, Gillian, Griffin, Anne, O'Shaughnessy, Íde. O'Carroll, Ida, Leahy, Siobhán, Trepel, Dominic, Ryan, Damian; Robinson, Katie, Galvin, Rose, A physiotherapy-led transition to home intervention for older adults following emergency department discharge: protocol for a pilot feasibility randomised controlled trial, Pilot and feasibility studies, 8, (1), 2022, p1--14
Saldanha, Ian J and Dodd, Susanna and Fish, Rebecca and Gorst, Sarah L and Hall, Deborah A and Jacobsen, Pamela and Kirkham, Jamie J and Trepel, Dominic and Williamson, Paula R, Comparison of published core outcome sets with outcomes recommended in regulatory guidance from the US Food and Drug Administration and European Medicines Agency: cross sectional analysis, BMJ Medicine, 1, (1), 2022
Saldanha, Ian J and Dodd, Susanna and Fish, Rebecca and Gorst, Sarah L and Hall, Deborah and Jacobsen, Pamela and Kirkham, Jamie J and Trepel, Dominic and Williamson, Paula, Representation of core outcomes in regulatory guidance from the FDA and EMA, BMJ Medicine, 2022
Trepel, Dominic, A Compendium Of Two Decades Of Economic Evaluations In Dementia And A Critique Of The Implied Use Of Resources, Alzheimer's Association International Conference, AAIC 2022, 2022
Dominic Trépel, Mairéad Conneely, Siobhán Leahy, Dominic Trépel, Katie Robinson, Fiona Boland, Frank Moriarty, Rose Galvin, Is there evidence of an association between acute healthcare utilisation and function in older adults over time? A Population-Based Cohort Study, Innovation in Aging, 2022
Persson, Sofie and Saha, Sanjib and Gerdtham, Ulf-G and Toresson, Hakan, Healthcare costs of dementia diseases before, during and after diagnosis: Longitudinal analysis of 17 years of Swedish register data, Alzheimer's & Dementia, 2022
Mitchell, Eileen and Ahern, Elayne and Saha, Sanjib and McGettrick, Grainne and Trepel, Dominic, The Value of Nonpharmacological Interventions for People With an Acquired Brain Injury: A Systematic Review of Economic Evaluations, Value in Health, 2022, p10.1016/j.jval.2022.03.014
Ritchie, CW and Waymont, JMJ and Pennington, C and Draper, K and Borthwick, A and Fullerton, N and Chantler, M and Porteous, ME and Danso, SO and Green, A and others, The Scottish Brain Health Service Model, The Journal of Prevention of Alzheimer's Disease volume, 2022
Kinchin, Irina and Edwards, Layla and Hosie, Annmarie and Agar, Meera and Mitchell, Eileen and Trepel, Dominic, Cost-effectiveness of clinical interventions for delirium: A systematic literature review of economic evaluations, Acta Psychiatrica Scandinavica, 2022
Conneely, Mairead, Leahy, Siobhan, Dore, Liz, Trépel, Dominic, Robinson, Katie, Jordan, Fionnuala, & Galvin, Rose, The effectiveness of interventions to reduce adverse outcomes among older adults following Emergency Department discharge: umbrella review, BMC geriatrics, 22, (1), 2022, p1--23
Workstream 5: feasibility cluster randomised controlled trial--process evaluation in, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, NIHR Journals Library, 2021, [Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others]
Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, 2021
Workstream 2: clarification of measurements in, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, NIHR Journals Library, 2021, [Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others]
Parra MA, Baez S, Sedeño L, Gonzalez Campo C, Santamaría-García H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farías GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, García AM, Garcia PJ, de Gobbi Porto FH, Duque Peñailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Muñoz-Nevárez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Piña Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Añari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trépel D, Ibanez A., Dementia in Latin America: Paving the way toward a regional action plan, Alzheimer's & Dementia, 2021
John Cullinan, Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding, Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE), Medicina, 57, (3), 2021, p208
Rentz DM, Wessels AM, Annapragada AV, Berger AK, Edgar CJ, Gold M, Miller DS, Randolph C, Ryan JM, Wunderlich G, Zoschg MC, Trépel D, Knopman DS, Staffaroni AM, Bain LJ, Carrillo MC, Weber CJ., Building clinically relevant outcomes across the Alzheimer's disease spectrum., Alzheimer's & dementia (New York, N. Y.), 7, (1), 2021, pe12181
Ritchie, Craig W and Waymont, Jennifer MJ and Pennington, Catherine and Draper, Kristy and Borthwick, Anna and Fullerton, Neil and Chantler, M and Porteous, Mary E and Danso, SO and Green, Alison and others, The Scottish Brain Health Service Model: Rationale and Scientific Basis for a National Care Pathway of Brain Health Services in Scotland, The Journal of Prevention of Alzheimer's Disease, 2021, p1--11
Bell, Phaedra and Allen, Isabel Elaine and Vega, Yvette and Lanata, Serggio and Power, Joanna McHugh and Trepel, Dominic and Perissinotto, Carla and Yaffe, Kristine and Miller, Bruce L and Lawlor, Brian, Effects of COVID-19 Adaptations for Older Participants in Multimodal Intergenerational Social Contact Intervention for Creative Engagement (MISCI-CE), 2021 Alzheimer's Association International Conference, 2021
Workstream 1: ethnographic observations of daily life in four care homes--final report in, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, NIHR Journals Library, 2021, [Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others]
Kinchin, I., Mitchell, E., Agar, M., Trépel, D. , The economic cost of delirium: A systematic review and quality assessment, Alzheimer's & Dementia, 2021
Testing out the acceptability and appropriateness of a range of outcome tools and measures in, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, NIHR Journals Library, 2021, [Forster, Anne and Godfrey, Mary and Green, John and McMaster, Nicola and Airlie, Jennifer and Cundill, Bonnie and Lawton, Rebecca and Hawkins, Rebecca and Hulme, Claire and Birch, Karen and others]
Mitchell, Eileen and Ahern, Elayne and Saha, Sanjib and Trepel, Dominic, Neuropsychological rehabilitation interventions for peopl e with an acquired brain injury and their caregivers. A protoco l for a systematic review of economic evaluation, HRB Open, 2020
Mairéad Conneely, Pauline Boland, Aoife O'Neill, David Byrne, Sinéad Cronin, Dominic Quinn, Dominic Trépel, Siobhán Leahy, Jon Salsberg, Rose Galvin, Katie Robinson, A protocol for the establishment and evaluation of an older adult stakeholder panel for health services research, HRB Open Research, 3, 2020, p1
Dominic Trépel, Shehzad Ali, Simon Gilbody, Alfonso Leiva, Dean Mcmillan, Ferran Bejarano, Ermengol Sempere, Caterina Vicens, Cost-effectiveness of brief structured interventions to discontinue long-term benzodiazepine use: an economic analysis alongside a randomised controlled trial, HRB Open Research, 3, 2020, p33
Derek Pheby, Diana Arleaaja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig Hughes, Rachael Hunter, Dominic Trepel, Xia Wang-Steverding, A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE), Healthcare, 2020
Derek F.H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A Hughes, Rachael M Hunter, Dominic Trepel, Xia Wang-Steverding, The Development of a Consistent Europe-Wide Approach to Investigating the Economic Impact of Myalgic Encephalomyelitis (ME/CFS): A Report from the European Network on ME/CFS (EUROMENE), Healthcare, 8, (2), 2020, p88
Derek F. H. Pheby, Diana Araja, Uldis Berkis, Elenka Brenna, John Cullinan, Jean-Dominique de Korwin, Lara Gitto, Dyfrig A. Hughes, Rachael M. Hunter, Dominic Trepel, Xia Wang-Steverding, A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE), Medicina, 57, (1), 2020, p7
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Smith, K.M., Randomised controlled trial and economic evaluation of a task-based weight management group programme, BMC Public Health, 19, (1), 2019
Walsh, D., Belton, S., Meegan, S., Bowers, K., Corby, D., Staines, A., McVeigh, T., McKeon, M., Hoey, E., Trépel, D., Griffin, P., Sweeney, M.R., A comparison of physical activity, physical fitness levels, BMI and blood pressure of adults with intellectual disability, who do and do not take part in Special Olympics Ireland programmes: Results from the SOPHIE study, Journal of Intellectual Disabilities, 22, (2), 2018, p154-170
Graham, Liz and Cicero, Robert and Clarke, David and Cundill, Bonnie and Ellwood, Alison and Farrin, Amanda and Fisher, Jill and Goodwin, Madeline and Hawkins, Rebecca and Hull, Karen and others, PATCH: posture and mobility training for care staff versus usual care in care homes: study protocol for a randomised controlled trial, Trials, 19, (1), 2018, p521
Graham, L., Cicero, R., Clarke, D., Cundill, B., Ellwood, A., Farrin, A., Fisher, J., Goodwin, M., Hawkins, R., Hull, K., Hulme, C., Trépel, D., Williams, R., Forster, A., PATCH: Posture and mobility training for care staff versus usual care in care homes: Study protocol for a randomised controlled trial 11 Medical and Health Sciences 1117 Public Health and Health Services, Trials, 19, (1), 2018
The economics of preventing dementia in, editor(s)Kate Irving, Eef Hogervorst, Deborah Oliveira, Miia Kivipelto , New Developments in Dementia Prevention Research: State of the Art and Future Possibilities, Routledge, 2018, pp156 - 169, [Trepel]
White, P.C.L., Wyatt, J., Chalfont, G., Bland, J.M., Neale, C., Trepel, D., Graham, H., Exposure to nature gardens has time-dependent associations with mood improvements for people with mid- and late-stage dementia: Innovative practice, Dementia, 17, (5), 2018, p627-634
Simon Gilbody, Helen Lewis, Joy Adamson, Katie Atherton, Della Bailey, Jacqueline Birtwistle, Katharine Bosanquet, Emily Clare, Jaime Delgadillo, David Ekers, Deborah Foster, Rhian Gabe, Samantha Gascoyne, Lesley Haley, Jahnese Hamilton, Rebecca Hargate, Catherine Hewitt, John Holmes, Ada Keding, Amanda Lilley-Kelly, Shaista Meer, Natasha Mitchell, Karen Overend, Madeline Pasterfield, Jodi Pervin, David A. Richards, Karen Spilsbury, Gemma Traviss-Turner, Dominic Trépel, Rebecca Woodhouse, Friederike Ziegler, Dean McMillan, Effect of Collaborative Care vs Usual Care on Depressive Symptoms in Older Adults With Subthreshold Depression: The CASPER Randomized Clinical Trial, JAMA, 2017
Wright, B., Tindall, L., Littlewood, E., Allgar, V., Abeles, P., Trépel, D., Ali, S., Computerised cognitive-behavioural therapy for depression in adolescents: Feasibility results and 4-month outcomes of a UK randomised controlled trial, BMJ Open, 7, (1), 2017
Poston, Lucilla and Bell, Ruth and Briley, Annette L and Godfrey, Keith M and Nelson, Scott M and Oteng-Ntim, Eugene and Sandall, Jane and Sanders, Thomas AB and Sattar, Naveed and Seed, Paul T and others, The UK Pregnancies Better Eating and Activity trial: phase 3--randomised controlled trial, NIHR Journals Library, 2017
Bosanquet, K., Adamson, J., Atherton, K., Bailey, D., Baxter, C., Beresford-Dent, J., Birtwistle, J., Chew-Graham, C., Clare, E., Delgadillo, J., Ekers, D., Foster, D., Gabe, R., Gascoyne, S., Haley, L., Hamilton, J., Hargate, R., Hewitt, C., Holmes, J., Keding, A., Lewis, H., McMillan, D., Meer, S., Mitchell, N., Nutbrown, S., Overend, K., Parrott, S., Pervin, J., Richards, D.A., Spilsbury, K., Torgerson, D., Traviss-Turner, G., Trépel, D., Woodhouse, R., Gilbody, S., Collaborative care for screen-positive elders with major depression (CASPER plus): A multicentred randomized controlled trial of clinical effectiveness and cost-effectiveness, Health Technology Assessment, 21, (67), 2017, p1-251
Trépel, D., Cost-effectiveness of interventions for the treatment of dementia disorders, Mental Health Economics: The Costs and Benefits of Psychiatric Care, 2017, p339-352
Lewis, H., Adamson, J., Atherton, K., Bailey, D., Birtwistle, J., Bosanquet, K., Clare, E., Delgadillo, J., Ekers, D., Foster, D., Gabe, R., Gascoyne, S., Haley, L., Hargate, R., Hewitt, C., Holmes, J., Keding, A., Lilley-Kelly, A., Maya, J., McMillan, D., Meer, S., Meredith, J., Mitchell, N., Nutbrown, S., Overend, K., Pasterfield, M., Richards, D., Spilsbury, K., Torgerson, D., Traviss-Turner, G., Trépel, D., Woodhouse, R., Ziegler, F., Gilbody, S., Collaborative care and active surveillance for screen-positive EldeRs with subthreshold depression (CASPER): A multicentred randomised controlled trial of clinical effectiveness and cost-effectiveness, Health Technology Assessment, 21, (8), 2017, p1-196
Hull, K and Forster, A and Farrin, A and Hulme, C and Fisher, J and Ellwood, A and Graham, L and Goodwin, M and Cicero, R and Trepel, D and others, From seed to sampling: growing the evidence, Physiotherapy, 103, 2017, pe124--e125
, Social Stories" to alleviate challenging behaviour and social difficulties exhibited by children with autism spectrum disorder in mainstream schools: design of a manualised training toolkit and feasibility study for a cluster randomised controlled trial w, Health technology assessment (Winchester, England), 2016
Plummer F, Manea L, Trepel D, McMillan D., Screening for anxiety disorders with the GAD-7 and GAD-2: a systematic review and diagnostic metaanalysis., General hospital psychiatry, 39, 2016, p24-31
Amanda Perry, Rebecca Woodhouse, Matthew Neilson, Marrissa Martyn St James, Julie Glanville, Catherine Hewitt, Dominic Trépel, Are Non-Pharmacological Interventions Effective in Reducing Drug Use and Criminality? A Systematic and Meta-Analytical Review with an Economic Appraisal of These Interventions, International Journal of Environmental Research and Public Health, 13, (10), 2016, p966
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Smith, K.M., Tackling obesity in areas of high social deprivation: Clinical effectiveness and cost-effectiveness of a task-based weight management group programme " A randomised controlled trial and economic evaluation, Health Technology Assessment, 20, (79), 2016
Overend, K., Lewis, H., Bailey, D., Bosanquet, K., Chew-Graham, C., Ekers, D., Gascoyne, S., Hems, D., Holmes, J., Keding, A., McMillan, D., Meer, S., Meredith, J., Mitchell, N., Nutbrown, S., Parrott, S., Richards, D., Traviss, G., Trépel, D., Woodhouse, R., Gilbody, S., Erratum to: CASPER plus (CollAborative care in screen-positive EldeRs with major depressive disorder): Study protocol for a randomised controlled trial. [Trials. (2014), 15, 451.], Trials, 17, (1), 2016
Staines, Anthony and Walsh, Denise and Corby, Deirdre and Bowers, Kirsty and Belton, Sarahjane and McVeigh, Treasa and McKeon, Michael and Trepel, Dominic and Griffin, Peter and Sweeney, Mary Rose, Edel Hoey, Journal of Intellectual Disabilities, 1, 2016, p20
, Social Stories in mainstream schools for children with autism spectrum disorder: a feasibility randomised controlled trial, BMJ Open, 2016
, PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages - a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation., Health technology assessment (Winchester, England), 2016
McRobbie, H., Hajek, P., Peerbux, S., Kahan, B.C., Eldridge, S., Trépel, D., Parrott, S., Griffiths, C., Snuggs, S., Myers Smith, K., Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme - a randomised controlled trial and economic evaluation, Health technology assessment (Winchester, England), 20, (79), 2016, p1-150
, An examination of the nutritional intake and anthropometric status of individuals with intellectual disabilities: Results from the SOPHIE study, Journal of Intellectual Disabilities, 2016
Wright, Barry and Marshall, David and Adamson, Joy and Ainsworth, Hannah and Ali, Shehzad and Allgar, Victoria and Moore, Danielle Collingridge and Cook, Elizabeth and Dempster, Paul and Hackney, Lisa and others, Qualitative analysis of the views of Social Story users, Health Technology Assessment, 2016
Melvin, Cathie and Miller, Vivien and Slade, Pauline and Spiby, Helen and Trepel, Dominic and Weeks, Andrew and Whorwell, Peter and Williamson, Maria, The feasibility and acceptability of using the Mother-Generated Index (MGI) as a Patient Reported Outcome Measure in a randomised controlled trial of maternity care, 2015
Richardson, Rachel and Trepel, Cost-effectiveness of methods to identify and treat mental health difficulties in young people who have offended, 2015
, Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis., Health technology assessment (Winchester, England), 2015
Quality Assessment of Diagnostic Accuracy Studies--version 2 field guide in, Screening for psychological and mental health difficulties in young people who offend: a systematic review and decision model, NIHR Journals Library, 2015, [Richardson, Rachel and Trepel]
, Screening for psychological and mental health difficulties in young people who offend: a systematic review and decision model, Health Technol Assess, 2015
Wright, Barry and Barry, Melissa and Hughes, Ellen and Trepel, Dominic, Supplementary systematic review 2: studies of severe attachment problems with a follow-up of 10 years or longer, Clinical effectiveness and cost-effectiveness of parenting interventions for children with severe attachment problems: a systematic review and meta-analysis, 2015
, People with intellectual disability and their families perspectives of Special Olympics Ireland: Qualitative findings from the SOPHIE study, Journal of Intellectual Disabilities, 2015
, Self-hypnosis for intrapartum pain management in pregnant nulliparous women: a randomised controlled trial of clinical effectiveness, BJOG: An International Journal of Obstetrics & Gynaecology, 2015
, An Economic Analysis of Home Care Services for People with Dementia [Executive Summary], 2015
Overend, Karen and Lewis, Helen and Bailey, Della and Bosanquet, Kate and Chew-graham, Carolyn and Ekers, David and Mitchell, Natasha and Nutbrown, Sarah and Parrott, Steve and Richards, David and others, STUDY PROTOCOL Open Access CASPER plus (CollAborative care in Screen-Positive versus usual GP care alone. The primary clinical outcome, depression severity, will be measured with the TRIALS, 2014
, Autism Spectrum Social Stories In Schools Trial (ASSSIST), BMJ open, 2014
, Computerised cognitive behaviour therapy for depression in adolescents: study protocol for a feasibility randomised controlled trial., 2014
, CASPER plus (CollAborative care in Screen-Positive EldeRs with major depressive disorder): study protocol for a randomised controlled trial, Trials, 2014
, Autism Spectrum Social Stories In Schools Trial (ASSSIST): study protocol for a feasibility randomised controlled trial analysing clinical and cost-effectiveness of Social Stories in mainstream schools., 2014
Fenn, B and Trepel, D and Dolan, C and Shoham, J and Sibson, V, Seasonal unconditional cash transfers and wasting in Niger, Annals of Nutrition and Metabolism, 63, 2013, p1002
, Health-related Quality of Life Measures in Economic Evaluations of Child and Adolescence Mental Health Interventions: A Systematic Review, JOURNAL OF MENTAL HEALTH POLICY AND ECONOMICS, 2012
Trepel, Dominic, Financing Dementia-What money is available, what does dementia need and will the required resources be received?, 2012
Trepel, D., An update on the economics of dementia care in Ireland, Irish Medical Journal, 105, (2), 2012
, Informal cost of dementia care - a proxy-good valuation in Ireland, Economic and Social Review, 2011
, An economic perspective of dementia care in Ireland: maximising benefits and maintaining cost efficiency, 2011
, Economic analyses of dementia care in Ireland and Europe- perception of services and care, the market value of informal care and changes in service utilisation attributed to comorbid depression, 2011
Trepel, Dominic, Dementia-Specific Informal Care-Replacement Costs in Ireland, Irish Journal of Medical Science, 180, (Suppl 10), 2011, pS341
Trepel, Dominic, An economic perspective of dementia care in Ireland, 2011
Trepel, D, An Economic Perspective of Dementia Care in Ireland: Executive Summary, 2010
Non-Peer-Reviewed Publications
Conneely, M and Leahy, S and Trepel, D, 267 WHAT IS THE IMPACT OF ACUTE HEALTHCARE UTILISATION ON FUNCTIONAL DECLINE IN OLDER ADULTS OVER TIME? A POPULATION-BASED COHORT STUDY, Strategies to enhance routine physical activity in care home residents: the REACH research programme including a cluster feasibility RCT, Programme Grants for Applied Research, 51, (Supplement_3), NIHR Journals Library, 2022, ppafac218--235
Trends in healthcare cover and healthcare use for older adults in Ireland during the in, editor(s)Niall Turner, Orna Donoghue, Rose Anne Kenny , Publication Preview Source Wellbeing and Health in Ireland's over 50s 2009-2016, Trinity College Dublin, 2018, pp151 - 174, [Roe, Lorna and Thomas, Steve and Trépel, Dominic]
Research Expertise
Projects
- Title
- ValueCare: The VALUE of unpaid CARE in Ireland, and how economic consequence varies by social, economic and health condition
- Summary
- Family carers are lauded as the backbone of care provision in Ireland and are an essential complement to formal healthcare. Yet their contribution is not explicitly valued and can commonly be overlooked by decision-makers. Drawing on responses of over 1,400 Irish carers surveyed this year, this Civil Society Partner proposes will estimate of the economic value of unpaid caring activity and, for the first time, will disaggregate the monetary value of carer contribution by social and economic situation of the carer and the condition of the cared-for person. The outputs will be influential many ongoing high-level policy and legislative discussions.
- Funding Agency
- Irish Research Council
- Date From
- 2022
- Date To
- 2023
- Title
- Health Economic Partnership between Trinity College Dublin and Public Health Agency Northern Ireland
- Summary
- In collaboration between the Public Health Agency Northern Ireland (PHA-NI) and Trinity College Dublin (TCD), a partnership has been established that aims to appraise the current basis for public health policy for older people who become frail. To achieve this aim, the central objectives of Phase 1 are to: (1) Critically appraise current evidence that support PHA-NI frailty policy; (2) Identify evidence gaps in knowledge on appropriate intervention strategies and agree appropriate searches to obtain best available evidence on effective strategies, and; (3) Develop a framework to determine the most efficient design of services across NI. In Phase 2, the best available evidence gathered during Phase 1, is incorporated into a decision analytic model that simulates the relative cost effectiveness of public health interventions for frail older people and ultimately aims to inform future public health policy for Northern Ireland.
- Funding Agency
- Health and Social Care Northern Ireland (R&D Division)
- Date From
- 2020
- Date To
- 2023
- Title
- The Economics of Brain Health: A state-of-the-art decision analytic framework to compare a range of potential alternative investments to prevent, treat or care for dementia
- Summary
- By 2030, there will be 65.7 million people with dementia worldwide and associated costs will reach €2 trillion per year. With no clinically meaningful treatment yet available, policymakers remain uncertain on how best to allocate resources to tackle dementia. Future health program allocation decisions will ideally account for evolving needs and opportunities. Potential intervention will span prevention, treatment, and care. The toolkit is expected to expand over time as research discovers new intervention options. Optimal investment portfolios will reflect local epidemiology and resources, as well as up-to-date estimates of intervention costs and effectiveness. The goal of this 3-year project (2022 " 2025) is to provide practical analytic tools to support health intervention policy, programming, and funding decisions related to Brain Health and Dementia.
- Funding Agency
- Global Brain Health Institute
- Date From
- 2022
- Date To
- 2025
- Title
- Developing a Regional Capacity in Health Economics for BrainLat: A cross-sectional study to inform economic evaluations on dementia in Chile
- Summary
- In Chile, there are currently over 200,000 persons living with dementia (PLWD) and, by 2050, this number is forecasted to exceed half a million. The associated national cost of dementia is $183 Million per annum and, by 2050, this will reach $457 Million. Given the implications of dementia, the Chilean Ministry of Health launched `Plan Nacional de Demencia: 2017-2025" (cost: $12.5 Million) and, to support implementation, this project will enhance dementia-specific Health Economics capacity for Chile (and for the wider BrainLat region). This BrainLat Seed Research Grant aims to estimate stage-specific Quality-Adjusted LifeYears (QALYs), and relevant costs, to allow adaptation of international economic models to inform resource allocation decisions in Chile. By providing proof-of-concept, this initiative also lays foundations to scale up dementia-specific health economic capacity to benefit the wider RedLat region. Further information: https://brainlat.uai.cl/research-and-networking-projects/seed-grants/developing-a-regional-capacity-in-health-economics-for-brainlat-a-cross-sectional-study-to-inform-economic-evaluations-on-dementia-in-chile/
- Funding Agency
- BrainLat
- Date From
- 2021
- Date To
- 2023
- Title
- Towards an integrated model of care for older adults transitioning from the Emergency Department to the community
- Summary
- Ireland like many other countries has seen a steady increase in life expectancy and has an ageing population. Internationally, health and social care systems are recognising that sustainable healthcare strategies for older adults need to move from acute, episodic care to longitudinal, coordinated and integrated care models. International evidence demonstrates that older adults account for up to 25% of all emergency department (ED) attendances and experience high rates of adverse outcomes following emergency care such as unscheduled ED return, unplanned hospital admission and functional decline. Given the significant incidence of adverse events in this population, there is very little research conducted to explore how integrated care may improve outcomes among those who are discharged from the ED. The overall aim of this programme of research is to develop and examine an evidence-based model of integrated care for older people following ED index visit that is planned around their needs and choices, to support them to live well in their own homes and communities. This aim will be realised through collaboration and meaningful engagement by the research team with service users, advocacy groups, health-decision makers and health-practitioners. The objectives include qualitative and quantitative syntheses of international evidence, analysis of local and national routine health data and meaningful engagement with stakeholders to inform the design, delivery and evaluation of an integrated model of care to improve patient, process, clinical and economic outcomes post ED index visit. This programme of work responds to and resonates with key priorities identified in national ageing, emergency and integrated care strategies relating to the development and delivery of a continuum of high quality care services and supports that are responsive to the changing needs and preferences of older adults. The proposal also aligns with key objectives of the WHO Guidelines on Integrated Care for Older People (2017).
- Funding Agency
- Health Research Board
- Date From
- 2021
- Date To
- 2026
- Title
- SENSE-Cog Care: A feasibility study of hearing and vision support to improve quality of life in care home residents with dementia
- Summary
- Of the 55,000 people with dementia in Ireland, nearly 17,000 live in nursing homes (Irish care homes). Over 90% of these residents have significant hearing and vision problems that are frequently undetected or under-corrected. Poor sensory function can worsen quality of life for residents with dementia (RwD) by making communication more difficult and increasing confusion and challenging behaviour. The study aims to ascertain the feasibility of delivery, acceptability and tolerability of a sensory support intervention in Irish nursing homes. To explore whether the sensory support intervention may be effective in improving quality of life and other outcomes for RwD and nursing home staff. To explore what Care as Usual looks like in nursing homes, and lastly, to evaluate cost-effectiveness parameters of the intervention. The findings from this study will inform progression to a definitive trial and contribute to emerging evidence of care home research methodology.
- Funding Agency
- Health Research Board
- Date From
- 2022
- Date To
- 2024
- Title
- Alignment, Harmonisation, and Results: translating Core Outcome Measures to Improve Care (COM-IC) for People Living with Dementia
- Summary
- The Core Outcome Measures for Improving Care (COM-IC) project aims to identify a suite of outcome measures that are aligned with stakeholder goals; and develop guidelines for implementation that ensure Australia"s efforts to improve the lives of people living with dementia are unequivocally realised. The COM-IC Project will use a participatory co-design strategy to incorporate practical knowledge, experience and preferences of all stakeholders as inputs in each step of the process. The participatory co-design framework will ensure the suite of core outcomes identified and recommended to evaluate dementia interventions and care delivery model are important, relevant, authentic and practical for each stakeholder group. Research objectives Primary Objective: Development of a comprehensive and appropriate suite of core outcome measures accompanied by guidelines (developed according to NHMRC guideline methodology) to monitor and evaluate impacts of care delivery models at individual, organisation and system levels, that are informed by all stakeholders. Secondary Objectives 1. To understand, report and collectively prioritise multiple stakeholders" preferences on core outcome measures to evaluate success of interventions and care delivery models for people living with dementia 2. To map the core outcome sets for dementia into the indicators that are routinely collected in the Australian health and aged care systems To achieve consensus of what to recommend as a suite of core outcome measures for dementia. 3. To determine best practices in measuring, collecting, curating, evaluating, reporting and translating the recommended suite of core outcome measures for dementia. 4. To develop methods to monitor the delivery of Commonwealth and State, Health and Aged Care services at the level of Local Hospital Networks.
- Funding Agency
- National Health and Medical Research Council (NHMRC)
- Date From
- 2022
- Date To
- 2024
- Title
- "Right Care": a programme of research to enhance safe and appropriate care for older patients in Ireland
- Funding Agency
- Health Research Board
- Date From
- 2018
- Date To
- 2023
- Title
- Dementia Research Network Ireland (DRNI)
- Summary
- DRNI links leading researchers across several disciplines in the areas of dementia and ND, it is novel in its multi-disciplinary focus and strategic in its objective to enhance research co-operation and co-ordination across the island of Ireland. By facilitating collaborative consensus and policy based projects and supporting knowledge exchange and public patient events DRNI seeks to improve our understanding of the causes and mechanisms of dementia and neurodegeneration, the effectiveness of different models of care and the policy changes required to improve the quality of life for persons with dementia and neurodegenerative conditions and their caregivers. The inter-disciplinary nature of the network is highly innovative and reflects the emerging international evidence of the role of multi-modal influences on dementia and neurodegeneration. It reflects the network members" belief that the integration of knowledge and practice from diverse research traditions has the potential to radically improve our understanding of dementia and ND, in relation to prevention, care and quality of life. To further network objectives DRNI works collaboratively with the Structured Population and Health Services Research Education (SPHeRE) network which strives to increase cross-disciplinary interaction and collaboration in the area of population health and health services research. Combined the networks serve to act as a conduit to link researchers in the field of dementia and ND with statutory and non-statutory bodies, including, funding agencies, government, patient advocacy, charities, health service organisations, industries, and philanthropic organisations.
- Funding Agency
- Health Research Board
- Date From
- 2022
- Date To
- 2024
- Title
- The Frail Brain and the Frail Body: Impact of FRAILty and COGnitive impairment on trajectories, patterns and costs in care in old age
- Funding Agency
- Health Research Board
- Date From
- 2019
- Date To
- 2024
- Title
- An Economic evaluation of Acquired Brain Injury Rehabilitation Models: Developing evidence to inform the Irish Health System
- Funding Agency
- Irish Research Council
- Date From
- 2020
- Date To
- 2022
Recognition
Representations
Scientific review committee, EU Joint Program for Neurogenerative Research (JPND)
Editorial board of Alzheimers and Dementia Journal