Professor Roman Romero-Ortuno
Professor In/ Assoc Prof Consultant, Medical Gerontology
Biography
Roman Romero-Ortuno is Professor in Medical Gerontology in the School of Medicine and Consultant Physician in St. James's Hospital, Dublin.
In 2002, he graduated from University of Barcelona with a degree in Medicine, and in 2003 he completed an MSc in European Social Policy at the London School of Economics and Political Science. He has a music degree from the Conservatory of Barcelona. His basic postgraduate medical training took place in Manchester and London and his higher medical training in Geriatric and General (Internal) Medicine was completed in Dublin.
Between 2014 and 2018 he worked as a Consultant Geriatrician in Addenbrooke's Hospital (Cambridge University Hospitals NHS Foundation Trust) and during that time he held an Honorary Visiting Fellowship to the Clinical Gerontology Unit of the Department of Public Health and Primary Care, University of Cambridge.
Prof. Ortuno is Faculty member of the Global Brain Health Institute (GBHI) where he brings clinical and academic expertise in frailty, dementia, delirium and comprehensive geriatric assessment. He co-chairs the Irish Frailty Network (IFN) of the Irish Gerontological Society. He is Board Member of the Geriatric Medicine Section of the European Union of Medical Specialists (UEMS).
His research contributions in the area of frailty have been recognised with the 2015 British Geriatrics Society Rising Star Award, the 2017 Count of Cartagena Award from the Royal National Academy of Medicine of Spain and the 2018 President of Ireland Future Research Leaders Award.
In December 2020, Prof. Ortuno was appointed as Associate Director of Postgraduate Teaching and Learning (M.D. Studies); and in August 2022, he was elected Head of the Discipline of Medical Gerontology in Trinity's School of Medicine (2022-2025).
On the 1st October 2022, Prof. Ortuno was promoted to the grade of Professor In Medical Gerontology. On Monday 24th April 2023, he was elected to Fellowship of Trinity College Dublin. In 2024, he was elected to the EuGMS Executive Board as Director for Education & Training (2024-2027).
Publications and Further Research Outputs
Peer-Reviewed Publications
Laura Orlandini, Enrica Patrizio, Aisling M O'Halloran, Christine A McGarrigle, Roman Romero Ortuno, Rose Anne Kenny, Marco Proietti, Matteo Cesari, Social vulnerability, frailty and self-perceived health: findings from The Irish Longitudinal Study on Ageing (TILDA), The Journal of Frailty & Aging, 2024
Chenhuichen, C. and Oâ Halloran, A.M. and Lang, D. and Kenny, R.A. and Romero-Ortuno, R., The lived experience of frailty: beyond classification and towards a holistic understanding of health, European Geriatric Medicine, 2024
Lucía Lozano-Vicario; Fabiola Zambom-Ferraresi; Fabricio Zambom- Ferraresi; Mikel L. Sáez de Asteasu; Arkaitz Galbete-Jiménez; Ángel Javier Muñoz- Vázquez; Bernardo Abel Cedeno-Veloz; Antón De la Casa-Marín; Iranzu Ollo- Martínez; Joaquín Fernández-Irigoyen5; Enrique Santamaría; Ramón San Miguel Elcano; José Ramón Ortiz-Gómez; Román Romero-Ortuño; Mikel Izquierdo; Nicolás Martínez-Velilla, Effects of exercise intervention for the management of delirium in hospitalized older adults: a randomized clinical trial, Journal of the American Medical Directors Association, 2024
Lucía Lozano-Vicario, Ángel Javier Muñoz-Vázquez, Robinson Ramírez-Vélez, Arkaitz Galbete-Jiménez, Joaquín Fernández-Irigoyen, Enrique Santamaría, Bernardo Abel Cedeno-Veloz, Fabricio Zambom-Ferraresi, Barbara C. Van Munster, José Ramón Ortiz-Gómez, Ángel Manuel Hidalgo-Ovejero, Román Romero-Ortuno, Mikel Izquierdo & Nicolás Martínez-Velilla, Association of postoperative delirium with serum and cerebrospinal fluid proteomic profiles: a prospective cohort study in older hip fracture patients, GeroScience, 2024
J. Oscanoa T, Amado-Tineo J, Matta-Pérez J, Taype-Huamaní W, Carvajal A, Romero-Ortuno R., Ivermectin-Induced Liver Injury Due to Self-Medication in SARS-CoV-2 Infection, Govaresh, 2024
Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny, The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand, The Journals of Gerontology: Series A, 2024
Kennedy F, Ní Cheallaigh C, Romero-Ortuno R, Doyle SL, Broderick J, Outcomes of the LEAP feasibility trial - a low-threshold, exercise programme with protein supplementation to target frailty and poor physical functioning in people experiencing homelessness and addiction issues, BMJ Open, 2024
Research using Big Data from Longitudinal Studies and Clinical Sources in, editor(s)Finbarr C. Martin Tan Maw Pin , The Oxford Textbook of Geriatric Medicine, 2024, [Silvin Knight, Roman Romero-Ortuno]
Mische-Jasmine McKelvie, Sharon Cruise, Mark Ward, Roman Romero-Ortuno, Frank Kee, Rose Anne Kenny, Dermot O"Reilly, Aisling M O"Halloran, Frailty on the island of Ireland: evidence from the NICOLA and TILDA studies, European Journal of Public Health, 2024
Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O"Halloran, Morgana Afonso Shirsath, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Were Frailty Identification Criteria Created Equal? A Comparative Case Study on Continuous Non-Invasively Collected Neurocardiovascular Signals during an Active Standing Test in the Irish Longitudinal Study on Ageing (TILDA), Sensors, 2024
Chenhui Chenhuichen, Aisling M. O'Halloran, Deirdre Lang, Rose Anne Kenny, Roman Romero-Ortuno, The Lived Experience of Frailty: Beyond Classification and Towards a Holistic Understanding of Health, European Geriatric Medicine, 2024
Elena Lionetti, Eoin Duggan, Roman Romero-Ortuno, The SHARE Frailty Instrument for Primary Care was associated with sarcopenia, as measured by bioelectrical impedance, in falls clinic attendees, Journal of Frailty, Sarcopenia and Falls, 2024
Teodoro J. Oscanoa, María L. Guevara-Fujita, Ricardo M. Fujita, Maria Y. Muñoz-Paredes, Oscar Acosta, Román Romero-Ortuño, Association between polymorphisms of the VKORC1 and CYP2C9 genes and warfarin maintenance dose in Peruvian patients, British Journal Of Clinical Pharmacology, 2024
Feng Xue, Silvin P. Knight, Emma Connolly, Eoin Duggan, Roman Romero-Ortuno, Functional clustering of continuous cardiovascular and brain oxygenation signals during an active stand test in The Irish Longitudinal Study on Ageing (TILDA), EURASIP Proceedings, 31st European Signal Processing Conference (EUSIPCO 2023), Helsinki, Finland, 2023
Peter Hartley, Faye Forsyth, Scott Rowbotham, Robert Briggs, Rose Anne Kenny, Roman Romero-Ortuno , The Use of the World Guidelines for Falls Prevention and Management's Risk Stratification Algorithm in Predicting Falls in The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2023
Hartley, P. and Forsyth, F. and Rowbotham, S. and Briggs, R. and Kenny, R.A. and Romero-Ortuno, R., The use of the World Guidelines for Falls Prevention and Management's risk stratification algorithm in predicting falls in The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 52, (7), 2023
Gutiérrez-Zúñiga R, Davis J.R., Boyle R, De Looze C, Meaney J, Whelan R, Kenny R.A., Knight S.P., Romero-Ortuño R, Brain connectivity in frailty: insights from The Irish Longitudinal Study on Ageing (TILDA), Neurobiology of Aging, 2023
Donnell DO, Romero-Ortuno R, Kennelly SP, O'Neill D, Donoghue PO, Lavan A, Cunningham C, McElwaine P, Kenny RA, Briggs R., The 'Bermuda Triangle' of orthostatic hypotension, cognitive impairment and reduced mobility: prospective associations with falls and fractures in The Irish Longitudinal Study on Ageing. , Age and Ageing, 52, (2), 2023, pafad005
Teodoro J. Oscanoa, Edwin Cieza-Macedo, Xavier Vidal, Roman Romero-Ortuno, Evaluation of the Timed Up and Go test for screening vulnerability and frailty in older cancer patients, Oncology in Clinical Practice, 2023
Peter Hartley, Olivia Sharpe, Roman Romero-Ortuno, Older Hospitalised Patients' Reported Confidence in Managing Discharge Needs: a Retrospective Observational Study, Journal of Frailty, Sarcopenia and Falls, 2023
Knight, S.P. and Refojo, J. and Newman, L. and Rizzo, R. and Tinney, H. and Romero-Ortuno, R., â Dancing with Atomsâ A Tribute to Sheila Tinney, Leonardo, 56, (6), 2023, p592-597
Feng Xue, Silvin P. Knight, Emma Connolly, Aisling M. O"Halloran, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Comparative analysis of frailty identification criteria on continuous non-invasive neurocardiovascular signals during an active stand test in The Irish Longitudinal Study on Ageing (TILDA), European Geriatric Medicine, 19th European Geriatric Medicine (EuGMS) Congress, Helsinki, Finland, 20-22 September 2023, 2023
Helen Doherty, Aurora Higgins Jennings, Matej Kocka, Auriane Neichel, Juliette Scauso, Elena Lionetti, Chenhui Chenhuichen, Roman Romero-Ortuno, A Narrative Review of the Utilisation of the SHARE Frailty Instruments (SHARE-FI and SHARE-FI75+) in the Literature, Journal of Frailty, Sarcopenia and Falls, 2023
Teodoro J. Oscanoa, Xavier Vidal, Brady E. Beltran, Roman Romero-Ortuno, Comprehensive geriatric assessment and clinical outcomes of frail older adults with diffuse large B-cell lymphoma: a metanalysis, Oncology in Clinical Practice, 2023
Gutiérrez-Zúñiga R, Davis J.R., Ruddy K, De Looze C, Carey D, Meaney J, Kenny R.A., Knight S.P. and Romero-Ortuno R, Structural brain signatures of frailty, defined as accumulation of self-reported health deficits in older adults, Frontiers in Aging Neuroscience, 2023
Peter Hartley, Faye Forsyth, Aisling O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Eight-year longitudinal falls trajectories and associations with modifiable risk factors: evidence from The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2023
Marcia Regina Cominetti, Henrique Pott-Jr, Raquel Gutiérrez Zúñiga, Roman Romero-Ortuno, Protecting cognitive function in older adults with age-related hearing loss: Insights from The Irish Longitudinal Study on Ageing (TILDA) and the role of hearing aids, Archives of Gerontology and Geriatrics, 2023
Eoin Duggan, Glenn Jennings, Ann Monaghan, Lisa Byrne, Feng Xue, Roman Romero-Ortuno, Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid, IEEE Journal of Translational Engineering in Health & Medicine, 2023
Eoin Duggan, Silvin P. Knight, Roman Romero-Ortuno, Relationship Between Sarcopenia and Orthostatic Blood Pressure Recovery in Older Falls Clinic Attendees, European Geriatric Medicine, 2023
Knight SP, Ward M, Duggan E, Xue F, Kenny RA, Romero-Ortuno R. , Evaluation of a 3-Item Health Index in Predicting Mortality Risk: A 12-Year Follow-Up Study, Diagnostics, 2023
Elizabeth Moloney, Mark O"Donovan, Fabio Salvi, Elsa Dent, Jean Woo, John Morley, Roman Romero-Ortuno, Emer Ahern, Ruth Hubbard, Matteo Cesari, Christopher Carpenter, Rosa McNamara, Anne O"Keeffe, Anne Healy, Pieter Heeren, Darren McLoughlin, Conor Deasy, Louise Martin, Simon Mooijaart, Audrey Ann Brousseau, Emiel Hoogendijk, Duygu Sezgin, Paul Bernard, Kara McLoughlin, Jiraporn Sri-On, Don Melady, Lucinda Edge, Ide O"Shaughnessy, Jill Van Damme, Jennifer Kirby, Lauren Southerland, Andrew Costa, Douglas Sinclair, Cathy Maxwell, Marie Doyle, Ebony Lewis, Grace Corcoran, Debra Eagles, Frances Dockery, Magnolia Cardona, Simon Conroy, Suzanne Timmons, Rónán O"Caoimh, Core requirements of frailty screening in the emergency department:an international Delphi consensus study, AGE AND AGEING, 2023
Teodoro J. Oscanoa, Roman Romero-Ortuno, The identification of frailty in older people living with diffuse large B-cell lymphoma: a systematic review, Acta Haematologica Polonica, 2023
Nicola Veronese, Pinar Soysal, Jacopo Demurtas, Marco Solmi, Olivier Bruyère, Nikos Christodoulou, Rodrigo Ramalho, Paolo Fusar-Poli, Andreas S. Lappas, Daniel Pinto, Kristian Steen Frederiksen, Grazia Maria Corbi, Olga Karpenko, Jean Georges, João Durães, Mathias Schlögl, Ozlem Yilmaz, Cornel Sieber, Susan D. Shenkin, Lee Smith, Jean-Yves Reginster, Stefania Maggi, Federica Limongi, Joan Ars, Mario Barbagallo, Antonio Cherubini & Terry Quinn, on behalf of Alzheimer Europe, European College of Neuropsychopharmacology, European Geriatric Medicine Society (Lead Society) (including Roman Romero-Ortuno), European Interdisciplinary Council on Ageing, European Society of Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, International Association of Gerontology and Geriatrics-European Region, Scottish Brain Health ARC, World Psychiatry Association-Preventive Psychiatry Section & endorsed by the European Academy of Neurology, Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline, European Geriatric Medicine, 2023
Travers J, Romero-Ortuno R, Langan J, MacNamara F, McCormack D, McDermott C, McEntire J, McKiernan J, Lacey S, Doran P, Power D, Cooney MT, Building resilience and reversing frailty: a randomised controlled trial of a primary care intervention for older adults, Age and Ageing, 2023
Gülendam Hakverdioğlu Yönt, Roman Romero-Ortuno, Fisun Şenuzun Aykar, Duygu İlbay, TURKISH VERSION OF THE SHARE FRAILTY INSTRUMENT FOR PRIMARY CARE: RELIABILITY AND VALIDITY IN THE NURSING HOME SETTING, Journal of Frailty, Sarcopenia and Falls, 2023
Olga Theou, Myles W. O'Brien, Judith Godin, Chris Blanchard, Leah Cahill, Mohammad Hajizadeh, Peter Hartley, Pamala Jarrett, Dustin Scott Kehler, Roman Romero-Ortuno, Renuka Visvanathan, Kenneth Rockwood, Interrupting Bedtime to Reverse Frailty Levels in Acute Care: A Study Protocol for the Breaking Bad Rest Randomized Controlled Trial, BMC Geriatrics, 2023
Teodoro Oscanoa, Xavier Vidal, Julio Luque, Dante I. Julca, Roman Romero-Ortuno, Hepatotoxicity induced by isoniazid in patients with Latent tuberculosis infection: a metanalysis, Gastroenterology and Hepatology from Bed to Bench, 2023
Lozano-Vicario, Lucía; García-Hermoso, Antonio; Cedeño-Veloz, Bernardo Abel; Fernández-Irigoyen, Joaquín; Santamaría, Enrique; Romero-Ortuno, Román; Zambom-Ferraresi, Fabricio; L. Sáez de Asteasu, Mikel; Muñoz-Vázquez, Ángel Javier; Izquierdo, Mikel; Martínez-Velilla, Nicolás, Biomarkers of delirium risk in older adults: a systematic review and meta-analysis, Frontiers in Aging Neuroscience, 2023
Bernardo Cedeno-Veloz, Lucia Lozano-Vicario, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Enrique Santamaría, Alba Rodríguez-García, Roman Romero-Ortuno, Jaime Mondragon-Rubio, Javier Ruiz-Ruiz, Robinson Ramírez-Vélez, Mikel Izquierdo, Nicolás Martínez-Velilla, Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults, Immunity & Ageing, 2023
Sara Solis-López, Aníbal Gutiérrez-Torres, Alejandro López-Valdés, José Alberto Ávila-Funes, Carmen García-Peña, Brian Lawlor, Roman Romero-Ortuno, Age-friendly initiatives: Mexico, The Journal of nutrition, health and aging, 2023
Eoin Duggan, Silvin P. Knight, Feng Xue, Roman Romero-Ortuno, Haemodynamic Parameters Underlying the Relationship Between Sarcopenia and Blood Pressure Recovery on Standing, Journal of Clinical Medicine, 2023
Silvin P. Knight, Jose Refojo, Louise Newman, Rossella Rizzo, Hugh Tinney, Roman Romero-Ortuno , "Dancing with Atoms": A tribute to Sheila Tinney, Leonardo, 2023
Giulia Rivasi, Ludovica Ceolin, Giada Turrin, Virginia Tortù, Maria Flora D'Andria, Giuseppe Dario Testa, Sara Montali, Francesco Tonarelli, Enrico Brunetti, Mario Bo, Roman Romero-Ortuno, Enrico Mossello, Andrea Ungar, Prevalence and correlates of frailty in older hypertensive outpatients according to different tools: the HYPER-FRAIL pilot study, Journal of Hypertension, 2023
Kennedy, F, Romero-Ortuno R, Ní Cheallaigh C, Doyle S, Broderick J, `"It"s like a free drug"" Low Threshold Exercise & Nutritional Programmes for People with Severe & Multiple Disadvantage Accessing Services for Addiction Challenges & Homelessness, International Conference of the Faculty for Homeless and Inclusion Health , London, UK, March 16-17, 2023
F Kennedy, R Romero-Ortuno, C Ní Cheallaigh, S Doyle, J Broderick, A FEASIBILITY STUDY TO EXPLORE THE ROLE OF EXERCISE AND PROTEIN SUPPLEMENTATION TO TARGET FRAILTY IN PEOPLE EXPERIENCING HOMELESSNESS, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
E Connolly, SL Doyle, RA Kenny, R Romero-Ortuno, ASSOCIATIONS BETWEEN ORTHOSTATIC BLOOD PRESSURE BEHAVIOUR AND PROGRESSION OF AGE-RELATED MACULAR DEGENERATION IN THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA), Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Teodoro J. Oscanoa, Rawia A. Ghashut, Alfonso Carvajal, Roman Romero-Ortuno, Association between low serum vitamin d and Increased mortality and severity due to COVID-19: reverse causality?, Disaster and Emergency Medicine Journal, 2022
Silvin P. Knight, Mark Ward, James Davis, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, The prediction of mortality from continuous noninvasive cardiovascular signals on standing: entropy was significant, but not the overall response profile, EURASIP Proceedings, 30th European Signal Processing Conference: EUSIPCO 2022, Belgrade, Serbia, 29/08 - 2/09, 2022
Peter May, Charles Normand, Soraya Matthews, Rose Anne Kenny, Roman Romero-Ortuno, Bryan Tysinger, Projecting future health and service use among older people in Ireland: an overview of a dynamic microsimulation model in The Irish Longitudinal Study on Ageing (TILDA), HRB Open Research, 2022
Lucía Lozano-Vicario, Fabíola Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Antón De la Casa-Marín, Iranzu Ollo-Martínez, Mikel L. Sáez de Asteasu, Bernardo Abel Cedeño-Veloz, Joaquín Fernández-Irigoyen, Enrique Santamaría, Roman Romero-Ortuno, Mikel Izquierdo and Nicolás Martínez-Velilla, Effectiveness of a multicomponent exercise training programme for the management of delirium in hospitalized older adults using Near-Infrared Spectroscopy (NIRS) as a biomarker of brain perfusion: study protocol for a randomized controlled trial, Frontiers in Aging Neuroscience, 2022
B Hernandez, A Dyer, B Nipoti, C McCrory, R Briggs, S Kennelly, C Finucane, R Romero-Ortuno, R Reilly, RA Kenny, DIABETES IS ASSOCIATED WITH IMPAIRED PERIPHERAL AND CEREBRAL HAEMODYNAMIC RESPONSES IN OLDER ADULTS, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Xue Feng, Monaghan Ann, Jennings Glenn, Byrne Lisa, Foran Tim, Duggan Eoin, Romero-Ortuno Roman, A Novel Methodology for the Synchronous Collection and Multimodal Visualization of Continuous Neurocardiovascular and Neuromuscular Physiological Data in Adults with Long COVID, Sensors, 22, (5), 2022
Rossella Rizzo, Silvin P. Knight, James R. C. Davis, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Longitudinal study on Sustained Attention to Response Task (SART): clustering approach for mobility and cognitive decline, Geriatrics (Basel), 2022
Oscanoa, T.J. and Amado, J. and Romero-Ortuno, R. and Carvajal, A., Hepatic disorders associated with the use of Ivermectin for SARSCoV-2 infection in adults: A pharmacovigilance study in VigiBase, Gastroenterology and Hepatology from Bed to Bench, 15, (4), 2022, p426-429
Ann Monaghan, Glenn Jennings, Feng Xue, Lisa Byrne, Eoin Duggan and Roman Romero-Ortuno, Orthostatic intolerance in adults reporting long COVID symptoms was not associated with postural orthostatic tachycardia syndrome, Frontiers in Physiology-Autonomic Neuroscience, 2022
Eoin Duggan, Ola Bademosi, Roman Romero-Ortuno, Muscle mass measured by bioelectrical impedance analysis was associated with handgrip strength but not with chair stands time in older falls clinic attendees, 18th Congress of the European Geriatric Medicine Society, London and Online, 28-30 September 2022, 2022
Glenn Jennings, Ann Monaghan, Feng Xue, Eoin Duggan, Román Romero-Ortuño, Comprehensive clinical characterisation of brain fog in adults reporting long COVID symptoms, Journal of Clinical Medicine, 2022
Silvin P. Knight, Mark Ward, Louise Newman, James Davis, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, Cardiovascular signal entropy predicts all-cause mortality: evidence from The Irish Longitudinal Study on Ageing (TILDA), Entropy (Basel), 2022
Desmond O'Donnell, Roman Romero-Ortuno, Sean Kennelly, Desmond O'Neill, Patrick O'Donoghue, Amanda Lavan, Conal Cunningham, Paul McElwaine, Rose Anne Kenny, Robert Briggs , The 'Bermuda Triangle' of Orthostatic Hypotension, Cognitive Impairment and Reduced Mobility: Prospective Associations with Falls and Fractures in The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2022
Teodoro Oscanoa, José Amado, Roman Romero-Ortuno, Alfonso Carvajal, Hepatic disorders in adults associated with the use of Ivermectin for SARS-CoV-2 infection: a pharmacovigilance study in VigiBase, Gastroenterology and Hepatology From Bed to Bench, 2022
Jordi Amblàs-Novellas; Anna Torné; Ramon Oller; Joan Carles Martori; Joan Espaulella; Roman Romero-Ortuno, Transitions between degrees of multidimensional frailty among older people admitted to intermediate care: a multicentre prospective study, BMC Geriatrics, 2022
John Travers, Roman Romero-Ortuno, Marie-Therese Cooney, Testing the feasibility of a primary-care exercise intervention to prevent and reverse early frailty and build resilience in community-dwelling older adults, Lancet eClinicalMedicine, 2022
Marcia Regina Cominetti, Henrique Pott-Junior, Cristiane Cominetti, Raquel Gutiérrez Zúñiga, Roman Romero-Ortuno, Type 2 Diabetes Mellitus Predicts Cognitive Decline: Evidence from The Irish Longitudinal Study on Ageing (TILDA), Diabetes Epidemiology and Management, 2022
DO Donnell, R Romero-Ortuno, S Kennelly, RA Kenny, A Lavan, DO Neill, P McElwaine, R Briggs, The 'Bermuda Triangle' of Orthostatic Hypotension, Cognitive Impairment and Reduced Mobility: Associations with Falls and Fractures in Community-dwelling Older People, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Romero-Ortuno, R. and Stuck, A.E. and Masud, T., Age and Ageing journal 50th anniversary commentary series The giants of education in geriatric medicine and gerontology, Age and Ageing, 51, (2), 2022
R. Gutierrez Zuñiga, J. Davis, C. De Looze, D. Carey, J. Meany, A. O'Halloran, R. Kenny, R. Romero Ortuño, S. Knight , Association of the Frailty Index with structural brain volumes in The Irish Longitudinal Study on Ageing (TILDA), European Journal of Neurology, 8th Congress of the European Academy of Neurology, Vienna, Austria, June 25-28, 2022, 29, (Suppl. 1), 2022, pp120 - 120
Belinda Hernández, Siobhán Scarlett, Frank Moriarty, Roman Romero-Ortuno, Rose Anne Kenny, Richard Reilly, Investigation of the role of sleep and physical activity risk for chronic disease prevalence in older Irish adults, BMC Public Health, 2022
F Kennedy, R Romero-Ortuno, C Ní Cheallaigh, S Doyle, J Broderick, Protocol of an Intervention to Evaluate the Effects of an Optimised Exercise Programme with Protein Supplementation to Target Physical Functioning Deficits and Frailty in people Experiencing Addiction Issues and Homelessness, National Drugs Forum, Dublin , 03 November , 2022
Belinda Hernandz, Siobhan Scarlett, Frank Moriarty, Roman Romero Ortuno, Rose Anne Kenny, Richard Reilly, Investigation of the role of sleep and physical activity for chronic disease prevalence and incidence in older Irish adults, BMC Public Health, 22, (1), 2022, p1 - 11
Feng Xue, Ann Monaghan, Glenn Jennings, Lisa Byrne, Tim Foran, Eoin Duggan, Roman Romero-Ortuno, A novel methodology for the synchronous collection and multimodal visualization of continuous neurocardiovascular and neuromuscular physiological data in adults with long COVID, MDPI Sensors, 2022
Chen Y, Almirall-Sanchez A, Mockler D, Adrion E, Dominguez-Vivero C, Romero-Ortuno R, Hospital-associated deconditioning: not only physical, but also cognitive, International Journal of Geriatric Psychiatry, 2022
Yue Ting Tang, Roman Romero-Ortuno, Using Explainable AI (XAI) for the prediction of falls in the older population, Algorithms, 2022
J Travers, R Romero-Ortuno, M-T Cooney, É Ní Shé, CO-DESIGNING A PRIMARY-CARE INTERVENTION TO REVERSE FRAILTY AND BUILD RESILIENCE THROUGH PUBLIC AND PATIENT INVOLVEMENT WITH OLDER PEOPLE, Annual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology, Cavan, 3 - 4 November 2022, Age and Ageing, 2022
Silvin P. Knight, Eoin Duggan and Roman Romero‐Ortuno, Blood Pressure Signal Entropy as a Novel Marker of Physical Frailty: Results from the FRAILMatics Clinical Cohort, Journal of Clinical Medicine, 2022
C Murphy, E Duggan, S Knight, J Davis, RG Zuniga, E Connolly, RA Kenny, S McCarthy, R Romero-Ortuno, RELATIONSHIP BETWEEN SERUM CAROTENOID CONCENTRATIONS AND FRAILTY, PROBABLE SARCOPENIA, AND PHYSICAL FUNCTION IN THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA), Age and Ageing, Annual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology, 2022, 51, 2022
Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Cian Mangan, Fergal Howley, Siobhan O'Regan, Noor Adeebah Mohamed Razif, Ciara Conlan, Ruth Argue, Samuel Holohan, Adam Dyer, Fara Salleh, Liam Townsend, Gerard Hughes, Colm Kerr, Derval Reidy, Alberto Sanz, Emma Connolly, Andrea Kelly, Emma Leacy, Conor Reddy, Siobhan Gargan, Eamon Breen, Heike Hawerkamp, Jean Dunne, Ignacio Martin-Loeches, Anne Marie McLaughlin, Aideen Long, Orla Shiels, Padraic Fallon, Martina Hennessy, Roman Romero-Ortuno, Ciaran Bannan, Anna Rose Prior, Ana Rakovac, William McCormack, Ross McManus, Seamus Donnelly, Colm Bergin, Mark Little, Clíona Ní Cheallaigh, Niall Conlon, Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19, HRB Open Research, 2022
Hartley P, Monaghan A, Donoghue OA, Kenny RA, Romero-Ortuno R, Exploring bi-directional temporal associations between timed-up-and-go and cognitive domains in The Irish Longitudinal Study on Ageing (TILDA), Archives of Gerontology and Geriatrics, 2022
Donal J. Sexton, Roman Romero-Ortuno, Silvin P. Knight, Rozenn Dahyot, Rose Anne Kenny, Ali Karaali , Deep Learning Retinal Image Analysis for the Detection of CKD and Cardiovascular Risk Factors in the General Population, American Society of Nephrology (ASN) Kidney Week 2022, Orlando, FL, November 3-6, 2022
Bronagh Conroy, Niamh Murphy, Roman Romero-Ortuno, Conal Cunningham, Frances Horgan, Examining the factors associated with community ambulation in an older adult day hospital population, European Geriatric Medicine, 2022
O Bademosi, N Murphy, L Byrne, C Rice, R Briggs, A Lavan, S O'Callaghan, RA Kenny, C Cunningham, R Romero-Ortuno, EVALUATION OF A NEW PHYSIOTHERAPY-LED VESTIBULAR SERVICE EMBEDDED IN THE FALLS AND SYNCOPE UNIT, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
SP Knight, J Davis, E Duggan, RA Kenny, R Romero-Ortuno, ASSOCIATIONS BETWEEN CARDIOVASCULAR SIGNAL ENTROPY AND FUTURE FALLS, SYNCOPE, AND FEAR OF FALLING, Age and Ageing, Annual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology, 2022, 51, (Supplement_3), 2022
JRC Davis, R Boyle, SP Knight, R Romero-Ortuño, RG Zúñiga, GRIP STRENGTH, ONLY A PHYSICAL TASK? ASSOCIATIONS BETWEEN RESTING-STATE BRAIN CONNECTIVITY AND GRIP STRENGTH, Age and Ageing, Annual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology, 2022, 51, 2022
M McElheron, R Romero-Ortuno, RA Kenny, A O'Halloran, N Bourke, GENOME-WIDE ASSOCIATION ANALYSIS OF THE FRAILTY PHENOTYPE IN UK BIOBANK HIGHLIGHTS CARDIOMETABOLIC AND AUTOIMMUNE SIGNATURES IN AGEING, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
E Duggan, CH Murphy, SP Knight, JRC Davis, AM O'Halloran, RA Kenny, R Romero-Ortuno, INVESTIGATING THE RELATIONSHIP BETWEEN PROBABLE SARCOPENIA AND ORTHOSTATIC HYPOTENSION: FINDINGS FROM THE IRISH LONGITUDINAL STUDY ON AGEING, Age and Ageing, Annual and Scientific Meeting of the Irish Gerontological Society 2022: New Frontiers in Gerontology, 2022, 51, 2022
L Newman, JD O'Connor, R Romero-Ortuno, RB Reilly, RA Kenny, ORTHOSTATIC CEREBRAL OXYGENATION AND THE RELATIONSHIP WITH SYMPTOMS, SUPINE HYPERTENSION AND ORTHOSTATIC HYPOTENSION, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Patrick O'Donoghue, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno , Do The Frail Experience More Adverse Events From Intensive Blood Pressure Control? A 2-Year Prospective Study In The Irish Longitudinal Study On Ageing (TILDA), Lancet e-Clinical Medicine, 2022
F Xue, E Duggan, G Jennings, A Monaghan, R Romero-Ortuno, FATIGUE EXPERIENCED BY ADULTS WITH LONG-COVID WAS NOT ASSOCIATED WITH AN EMG-DERIVED MUSCLE FATIGUE INDEX, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Caoileann H. Murphy, Eoin Duggan, James Davis, Aisling M. O'Halloran, Silvin P. Knight, Rose Anne Kenny, Sinead N. McCarthy, Roman Romero-Ortuno, Plasma lutein and zeaxanthin concentrations associated with musculoskeletal health and incident frailty in The Irish Longitudinal Study on Ageing (TILDA), Experimental Gerontology, 2022
Mary Walsh, Helena Ferris, Louise Brent, Emer Ahern, Tara Coughlan, Roman Romero-Ortuno, Development of a Frailty Index in the Irish Hip Fracture Database, Archives of Orthopaedic and Trauma Surgery, 2022
Eoin Duggan, Caoileann H. Murphy, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Differential Associations Between Two Markers of Probable Sarcopenia and Continuous Orthostatic Hemodynamics in The Irish Longitudinal Study on Ageing, Journal of Gerontology: Medical Sciences, 2022
Roman Romero-Ortuno, Glenn Jennings, Feng Xue, Eoin Duggan, John Gormley, Ann Monaghan, Predictors of submaximal exercise test attainment in adults reporting long COVID symptoms, Journal of Clinical Medicine (Basel), 2022
Palina Piankova, Roman Romero-Ortuno, Aisling M O'Halloran, Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing, Geriatrics (Basel), 2022
Traversa, J. and Romero-Ortuno, R. and Nà Shé, à . and Cooney, M.-T., Involving older people in co-designing an intervention to reverse frailty and build resilience, Family Practice, 39, (1), 2022, p200-206
Patrick O'Donoghue, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, Frail by four different measures and new adverse events from lower blood pressure control in hypertensive older adults: a 2-year prospective study in The Irish Longitudinal Study on Ageing (TILDA), European Society of Cardiology Congress 2022, Barcelona, Spain, 26-29 August 2022, 2022
M Walsh, L Brent, E Ahern, T Coughlan, H Ferris, R Romero-Ortuno, DEVELOPMENT OF AN IRISH HIP FRACTURE DATABASE FRAILTY INDEX: ASSOCIATIONS WITH LENGTH OF STAY, DELIRIUM, MORTALITY AND NURSING HOME ADMISSION, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
O'Donoghue, P. and O'Halloran, A.M. and Kenny, R.A. and Romero-Ortuno, R., Do the frail experience more adverse events from intensive blood pressure control? A 2-year prospective study in the Irish Longitudinal Study on Ageing (TILDA), eClinicalMedicine, 45, (101304), 2022
Teodoro J. Oscanoa Espinoza, José Amado-Tineo, Ricardo Ayala-García, Roxana Mamani-Quiroz, Javier Matta-Pérez, Ángel Ardiles-Melgarejo, Carlos Marcos-Hernández, Waldo Taype-Huamaní, Jefferson Rojas-Guimaray, Sthephany Matos-Santiváñez, Loyda Miranda-Chávez, Ana Deza-Sime, Moisés Apolaya-Segura, Roman Romero-Ortuno, Clinical features and mortality predictors of older hospitalized patients with severe COVID-19 in Lima, Perú, Journal of Gerontology and Geriatrics, 2022
Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Deirdre O'Connor, Román Romero Ortuño, Rose Anne Kenny, An examination of the prevalence of metabolic syndrome in older adults in Ireland: Findings from The Irish Longitudinal Study on Ageing (TILDA), PLOS ONE, 2022
D O'Donnell, T Zainal, K Malomo, F Neasa, R Briggs, C Cunningham, R Romero-Ortuno, C Rice, RA Kenny, AH Lavan, PREVALENCE OF STOPPFALL FALLS-RISK-INCREASING DRUGS (FRIDS) IN PATIENTS PRESENTING TO HOSPITAL WITH A FALL, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Kevin McCarthy, Eamon Laird, Aisling M. O'Halloran, Padraic Fallon, Román Romero Ortuño, Rose Anne Kenny, Association between metabolic syndrome and risk of both prevalent and incident frailty in older adults: Findings from The Irish Longitudinal Study on Ageing (TILDA), Experimental Gerontology, 2022
K Moloney, T Byrne, S Mathews, M Foran, B Conroy, A Molamphy, N Murphy, A Dillon, K Doyle, C Cunningham, R Romero-Ortuno, THE IMPACT OF THE COVID-19 PANDEMIC ON THE ACTIVITY OF A RAPID-ACCESS GERIATRIC DAY HOSPITAL SERVICE, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
J Travers, R Romero-Ortuno, J Langan, F MacNamara, D McCormack, C McDermott, J McEntire, J McKiernan, S Lacey, P Doran, D Power, M-T Cooney, REVERSING FRAILTY AND ENHANCING RESILIENCE WITH EXERCISE AND DIETARY EDUCATION (REFEREE): A PRIMARY CARE RANDOMISED CONTROLLED TRIAL, Age and Ageing, 69th Annual & Scientific Meeting of the Irish Gerontological Society 2022, Cavan, 2022
Roman Romero-Ortuno, Andreas E. Stuck, Tahir Masud, The giants of education in geriatric medicine and gerontology, Age and Ageing, 2022
Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P and McCarron M., Factors associated with the progression of deficit accumulation frailty among adults with an intellectual disability: a systematic review revealing research gaps, HRB Open Research, 2021
Bailey L, Ward M, DiCosimo A, Baunta S, Cunningham C, Romero-Ortuno R, Kenny RA, Purcell R, Lannon R, McCarroll K, Nee R, Robinson D, Lavan A, Briggs R , Physical and Mental Health of Older People while Cocooning during the COVID-19 Pandemic, QJM, 2021
Frailty in, editor(s)Chan Daniel Yam Yin , Chans Practical Geriatrics 4e, Broookvale, N.S.W., BA Printing Services, 2021, [Roman Romero-Ortuno]
Sebastian Moguilner, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, The importance of Age in the prediction of Mortality by a Frailty Index: A Machine Learning approach in The Irish Longitudinal Study on Ageing, Geriatrics, 2021
Silvin Knight, Louise Newman, John O'Connor, Rose Anne Kenny, Roman Romero-Ortuno, Approximate entropies of resting state continuous neurocardiovascular physiological signals are associated with physical frailty in older adults, Entropy 2021: The Scientific Tool of the 21st Century, Entropy 2021: The Scientific Tool of the 21st Century, Virtual, 5-7 May 2021, 2021
Rossella Rizzo, Silvin Paul Knight, James Davis, Louise Newman, Eoin Duggan, Rose Anne Kenny, Roman Romero-Ortuno, SART and individual trial mistake thresholds: predictive model for mobility decline, Geriatrics, 2021
Being a frail older person at a time of COVID-19 pandemic in, editor(s)Paulo Oliveira and João Malva , AGING: FROM FUNDAMENTAL BIOLOGY TO SOCIETAL IMPACT, Elsevier, 2021, [Yaohua Chen, Susanne Röhr, Berenice Maria Werle, Roman Romero-Ortuno]
Louise Newman, John D. O'Connor, Roman Romero-Ortuno, Richard B. Reilly, Rose Anne Kenny, Supine hypertension is associated with an impaired cerebral oxygenation response to orthostasis: Findings from the Irish Longitudinal Study on Ageing (TILDA), HYPERTENSION, 2021
Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., & McCarron, M., Exploring a Social Conceptualisation of Frailty among Older Adults with an Intellectual Disability, Trinity Health and Education International Research Conference 2021 (THEconf2021): 'Transforming healthcare in a changing world: new ways of thinking and working', Dublin, 9th - 11th March, 2021
Oscanoa, T.J. and Amado, J. and Ghashut, R.A. and Romero-Ortuno, R., Relationship between serum 25-hydroxyvitamin d concentration and acute inflammatory markers in hospitalized patients with sars-cov-2 infection, Disaster and Emergency Medicine Journal, 6, (3), 2021, p144-153
Roman Romero-Ortuno, Peter Hartley, Rose Anne Kenny, Aisling O'Halloran, Frail by Different Measures: A Comparison of 8-year Mortality in The Irish Longitudinal Study on Ageing (TILDA), European Geriatric Medicine, 2021
James R. Davis, Silvin P. Knight, Orna A. Donoghue, Belinda Hernández, Rossella Rizzo, Rose Anne Kenny, Roman Romero-Ortuno, Comparison of gait speed reserve, usual gait speed, and maximum gait speed of adults aged 50+ in Ireland using explainable machine learning, Frontiers in Network Physiology: Networks in Aging and Frailty, 2021
Silvin P. Knight, Louise Newman, Siobhan Scarlett, John D. O'Connor, James Davis, Celine De Looze, Rose Anne Kenny, Roman Romero-Ortuno, Associations between Cardiovascular Signal Entropy and Cognitive Performance over Eight Years, Entropy, 2021
A.Monaghan, G. Jennings, F. Xue, S. Knight, R. Rizzo, J.Davis, E.Duggan, R.A. Kenny, R. Romero-Ortuño, ACUTE-PHASE BED-REST DURATIONWAS ASSOCIATED WITH LOWER GRIP STRENGTH IN A POST-COVID-19 COHORT, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021
Susanne Röhr, Francesca Rodriguez, Rosa Siemensmeyer, Felix Müller, Roman Romero-Ortuno, Steffi G. Riedel-Heller, How can urban environments support dementia risk reduction? A qualitative study, International Journal of Geriatric Psychiatry, 2021
Denys Gibbons, Jake McDonnell, Daniel Ahern, Gráinne Cunniffe, Rose Anne Kenny, Roman Romero-Ortuno, Joseph Butler, The Relationship between Radiological Paraspinal Lumbar Measures and Clinical Measures of Sarcopenia in Older Patients with Chronic Lower Back Pain, Journal of Frailty, Sarcopenia and Falls, 2021
Silvin P. Knight, Louise Newman, John D. O'Connor, James Davis, Rose Anne Kenny, Roman Romero-Ortuno , Associations between neurocardiovascular signal entropy and physical frailty, Entropy, 2021
Teodoro J. Oscanoa, José Amado, Rawia A. Ghashut, Roman Romero-Ortuno, Relationship between serum 25-hydroxyvitamin D concentration and acute inflammatory markers in hospitalized patients with SARS-CoV-2 infection: a systematic review, Disaster and Emergency Medicine Journal, 2021
Rizzo, R. and Knight, S.P. and Davis, J.R.C. and Newman, L. and Duggan, E. and Kenny, R.A. and Romero-Ortuno, R., Sart and individual trial mistake thresholds: Predictive model for mobility decline, Geriatrics (Switzerland), 6, (3), 2021
David Moloney, Silvin P. Knight, Louise Newman, Rose Anne Kenny, Roman Romero-Ortuno, Eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA): stability and clinical associations after 4 years, Geriatrics, 2021
Román Romero-Ortuño, Nicolás Martínez-Velilla, Richard Sutton, Andrea Ungar, Artur Fedorowski, Rose Galvin, Olga Theou, Andrew Davies, Richard B Reilly, Jurgen Claassen, Áine M Kelly, Plamen Ch. Ivanov, Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults, Frontiers in Network Physiology: Networks in Aging and Frailty, 2021
Duygu Sezgin, Mark O'Donovan, Jean Woo, Karen Bandeen-Roche, Giuseppe Liotta, Nicola Fairhall, Angel Rodríguez-Laso8, João Apóstolo, Roger Clarnette, Carol Holland, Regina Roller-Wirnsberger, Maddalena Illario, Leocadio Rodríguez Mañas, Miriam Vollenbroek-Hutten, Burcu Balam Yavuz, Cafer Balci, Francisco Orfila Pernas, Constança Paul, Emer Ahern, Roman Romero-Ortuno, William Molloy, Maria Therese Cooney, Diarmuid O'Shea, John Cooke, Deirdre Lang, Anne Hendry, Siobhán Kennelly, Kenneth Rockwood, Andrew Clegg, Aaron Liew, Rónán O'Caoimh, Early Identification of Frailty: Developing an International Delphi Consensus on Pre-frailty, Archives of Gerontology and Geriatrics, 2021
Neasa Fitzpatrick, Roman Romero-Ortuno, The Syncope-Falls Index (SYFI): A tool for predicting risk of syncope and complex falls in the older adult based on cumulative health deficits, QJM, 2021
Frailty in, editor(s)Simon Conroy, Chris Carpenter, Jay Banerjee , Silver Book II: Quality care for older people with urgent care needs, London, British Geriatrics Society, 2021, [Andrew Clegg, Kenneth Rockwood, Roman Romero-Ortuno, Conal Cunningham]
Moloney, D. and Romero-Ortuno, R. and Kenny, R.A., Vasovagal Syncope, JAMA Internal Medicine, 2021
Kieron Connolly, Conal Cunningham, Niamh Murphy, Roman Romero-Ortuno, Frances Horgan, Prevalence of Sarcopenia and Associated Factors in Older Adults Attending a Day Hospital Service in Ireland, European Geriatric Medicine, 2021
Teodoro J. Oscanoa, José Amado, Xavier Vidal, Andrea Savarino, Roman Romero-Ortuno, Metformin therapy and severity and mortality of SARS-CoV-2 infection: a meta-analysis, Clinical Diabetology, 2021
Teodoro J. Oscanoa, Xavier Vidal, Eamon Laird, Rawia A. Ghashut, Geert A. Martens, Roman Romero-Ortuno, Severity and Mortality of SARS-COV-2 infection and 25-hydroxyvitamin D concentration: a metanalysis, Advances in Respiratory Medicine, 2021
Tahir Masud, Giulia Ogliari, Eleanor Lunt, Adrian Blundell, Adam Lee Gordon, Regina Roller-Wirnsberger, Michael Vassallo, Daniela Mari, Marina Kotsani, Katrin Singler, Roman Romero-Ortuno, Alfonso Jose Cruz-Jentoft, Andreas Stuck, A scoping review of the changing landscape of Geriatric Medicine in undergraduate medical education: curricula, topics and teaching methods, European Geriatric Medicine, 2021
Shamik Giri, Lee Minn Chenn, Roman Romero-Ortuno, Nursing homes during the COVID-19 pandemic: a scoping review of challenges and responses, European Geriatric Medicine, 2021
Patrick J O'Donoghue, Paul Claffey, Ciara Rice, Lisa Byrne, Conal Cunningham, Rose Anne Kenny, Roman Romero-Ortuno, Association between gait speed and the SHARE Frailty Instrument in a Falls and Syncope Clinic, European Geriatric Medicine , 2021
Yaohua Sophie Chen, Susanne Rohr, Berenice Maria Werle, Roman Romero-Ortuno, Being a frail older person at the time of the COVID-19 pandemic, Alzheimer's Association International Conference (AAIC) Satellite Symposium on May 12-13, Online, 2021
Romero-Ortuno R, Infection in Dementia and Delirium in Frailty, Nature Aging, 2021
Oscanoa, T.J. and Amado, J. and Vidal, X. and Laird, E. and Ghashut, R.A. and Romero-Ortuno, R., The relationship between the severity and mortality of SARS-COV-2 infection and 25-hydroxy vitamin D concentration - a metaanalysis, Advances in Respiratory Medicine, 89, (2), 2021, p175-187
T. J. Oscanoa, E. C. Cieza, O. Grimaldo, Y. B. Andia, F. A. Lizaraso-Soto, M. L. Guevara, R. M. Fujita & R. Romero-Ortuno, Use of Angiotensin II Receptor Blockers, Angiotensin I-Converting Enzyme Polymorphism and Associations with Memory Performance in Older People, Advances in Gerontology, 2021
Georgia Richard, Aisling O'Halloran, Paul Doody, Joseph Harbison, Rose Anne Kenny, Roman Romero-Ortuno, Atrial Fibrillation and Acceleration of Frailty: Findings from The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 2021
Owen Thorpe, Elva McCabe, Elena Marie Herrero, William Ormiston Doyle, Aoife D Dillon, Lucinda Edge, Sinéad Flynn, Anna Mullen, Aisling Davis, Aoife Molamphy, Anna Kirwan, Robert Briggs, Amanda H Lavan, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Emer Kidney, Sarah-Jane Yeung, Deirdre Glynn, Frances Horgan, Conal Cunningham, Roman Romero-Ortuno, Scoring the Clinical Frailty Scale in the Emergency Department: The Home FIRsT Experience, Journal of Frailty, Sarcopenia and Falls, 2021
John Travers, Roman Romero-Ortuno, Éidin Ní Shé, Marie-Therese Cooney, Involving older people in co-designing a primary-care intervention to reverse frailty and build resilience, Family Practice, 2021
Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., and McCarron, M., Social frailty among older adults with an intellectual disability, Journal of Applied Research in Intellectual Disabilities, 6th IASSIDD Europe Congress: Value Diversity, Amsterdam, The Netherlands, 5th - 8th July 2021, 34, (5), Blackwell Publishing LTD, 2021, pp1181 - 1371
Moloney D, O'Connor J, Newman L, Scarlett S, Hernandez B, Kenny RA, Romero-Ortuno R, Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA), Age and Ageing, 50, (3), 2021, p854 - 860
J. Davis, S. P. Knight, R. Rizzo, O. A. Donoghue, R. A. Kenny and R. Romero-Ortuno, A linear regression-based machine learning pipeline for the discovery of clinically relevant correlates of gait speed reserve from multiple physiological systems, 2021 29th European Signal Processing Conference (EUSIPCO), Dublin, 2021
Kieron Connolly, Conal Cunningham, Niamh Murphy, Roman Romero-Ortuno, Frances Horgan, Using Accelerometers in the Assessment of Sarcopenia in Older Adults Attending a Day Hospital Service in Ireland, Journal of Frailty, Sarcopenia and Falls, 2021
E. Duggan, S. Knight, R. Rizzo, J.Davis, R.A. Kenny, R. Romero-Ortuño, LONGER CHAIR-STAND TIME IS ASSOCIATED WITH ORTHOSTATIC INTOLERANCE IN AN OLDER IRISH POPULATION, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021
Roman Romero-Ortuno, Peter Hartley, James Davis, Silvin P. Knight, Rossella Rizzo, Belinda Hernández, Rose Anne Kenny, Aisling M. O'Halloran, Transitions in frailty phenotype states and components over 8 years: evidence from The Irish Longitudinal Study on Ageing, Archives of Gerontology and Geriatrics, 2021
Glenn Jennings, Ann Monaghan, Feng Xue, David Mockler, Román Romero-Ortuño, A systematic review of persistent symptoms and residual abnormal functioning following acute COVID-19: Ongoing symptomatic phase vs. post-COVID-19 syndrome, Journal of Clinical Medicine, 2021
Teodoro J. Oscanoa, Xavier Vidal, Eliecer Coto, Roman Romero-Ortuno, ACE gene I/D polymorphism and severity of SARS-CoV-2 infection in hospitalized patients: a metanalysis, Arterial Hypertension, 2021
David Moloney, Rose Anne Kenny, Roman Romero-Ortuno, Longitudinal trajectories of pulse wave velocity and cognition in the Irish longitudinal study of ageing (TILDA), Journal of Human Hypertension, 2021 Annual Scientific Meeting of the British and Irish Hypertension Society (BIHS), Hilton Brighton Metropole, Brighton, 13-15 September 2021, 35, 2021, pp1 - 19
Romero-Ortuno R, Hartley P, Knight SP, Kenny RA and O'Halloran AM, Frailty index transitions over eight years were frequent in The Irish Longitudinal Study on Ageing, HRB Open Research, 2021
Peter Hartley, Roman Romero-Ortuno, Christi Deaton, A mixed-methods feasibility study of a sit-to-stand based exercise programme to maintain knee-extension muscle strength for older patients during hospitalisation, Journal of Frailty, Sarcopenia and Falls, 2021
Aisling M. O'Halloran, Peter Hartley, David Moloney, Christine McGarrigle, Rose Anne Kenny, Roman Romero-Ortuno, Informing patterns of health and social care utilisation in Irish older people according to the Clinical Frailty Scale, HRB Open Research, 2021
S. Knight, R. Boyle, L.Newman, J.Davis, R. Rizzo, E.Duggan, C.De Looze, R. Whelan, R.A. Kenny, R. Romero-Ortuno, HIGHER NEUROVASCULAR SIGNAL ENTROPY IS ASSOCIATED WITH ACCELERATED BRAIN AGEING, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021
Lutz, Sebastian , Exploration of Deep Learning Techniques for Natural Image Matting, Trinity College Dublin.School of Computer Science & Statistics, 2021
Y.T. Tang, R. Romero-Ortuno, APPLYING MACHINE LEARNING TO DIFFERENTIATE PREDICTORS OF SYNCOPE, SIMPLE AND COMPLEX FALLS IN THE IRISH LONGITUDINAL STUDY ON AGEING (TILDA), Age and Ageing, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021
Sebastian Moguilner, Silvin P. Knight, James R.C. Davis, Aisling M. O'Halloran, Rose Anne Kenny, Roman Romero-Ortuno, The Importance of Age in the Prediction of Mortality by a Frailty Index: A Machine Learning Approach in the Irish Longitudinal Study on Ageing, Geriatrics , 6, (3), 2021
R. Romero-Ortuno, R. A. Kenny, P. Hartley, A. M. O'Halloran and S. P. Knight, Alluvial visualization and computation of probabilities of transitions in frailty index states over an 8-year period using multi-state Markov models, 2021 29th European Signal Processing Conference (EUSIPCO), Dublin, 2021
J. Davis, S.P. Knight, R. Rizzo, O.A.Donoghue, R.A. Kenny, R. Romero-Ortuno, ASSOCIATIONS OF FRAILTY WITH CONSECUTIVE GAIT SPEED TRAILS MEASURED BOTH WITH AND WITHOUT ADDITIONAL STRESSORS, Annual and Scientific Meeting Virtual Meeting of the Irish Gerontological Society 70 Years of Change 1951-2021 18th November 2021, Online, 2021
Travers, J. Romero-Ortuno, R. Power, D. Doran, P. Langan, J. MacNamara, F. McCormack, D. McDermott, C. McEntire, J. McKiernan, J. Vencken, S. Murphy, A. W. Murphy, P. J. Ní Shé, É O'Shea, D. Cooney, M. T., Protocol for a randomised controlled trial of a primary care intervention to Reverse Frailty and Enhance Resilience through Exercise and dietary protein Education (REFEREE) in community-dwelling adults aged 65 and over, HRB Open Research, 2020
T.J. Oscanoa, E.C. Cieza, F.A. Lizaraso-Soto, M.L. Guevara, R.M. Fujita, J.F. Parodi, F.M. Runzer-Colmenares, R. Romero-Ortuno, Lack of association between angiotensin-converting enzyme genotype and muscle strength in Peruvian older people, Advances in Gerontology, 2020
Chintapalli R, Romero-Ortuno R, Choice reaction time and subsequent mobility decline: Prospective observational findings from The Irish Longitudinal Study on Ageing (TILDA), Lancet EClinicalMedicine, 2020
Dee, B., Burke, E., Romero-Ortuno, R., McCallion, P., & McCarron, M., Factors associated with frailty among older adults with an intellectual disability: a systematic review of the literature, Trinity Health and Education International Research Conference: Integrated Health Care Developing Integrated Person-Centered Health Systems, TheConfo2020, Dublin, 3rd - 5th March, 2020
O'Connor JD, O'Connell MD, Romero-Ortuno R, Hernandez B, Newman L, Reilly R, Kenny RA, Knight SP, Functional Analysis of Continuous, High-Resolution Measures in Ageing Research: A Demonstration using Cerebral Oxygenation Data from The Irish Longitudinal Study on Ageing, Frontiers in Human Neuroscience, section Cognitive Neuroscience, 2020
Teodoro J. Oscanoa, Xavier Vidal, Alfonso Carvajal, José Amado, Roman Romero-Ortuno, SEVERITY OF SARS-COV-2 INFECTION AND ANGIOTENSIN‐CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS: A META-ANALYSIS, Arterial Hypertension, 2020
Oscanoa TJ, Amado J, Vidal X, Romero-Ortuno R, Angiotensin-Receptor Blockers (ARBs) and risk of Alzheimer's Disease: A meta-analysis, Current Clinical Pharmacology, 2020
Hartley P, Romero-Ortuno R, Wellwood I, Deaton C, Changes in Muscle Strength and Physical Function in Older Patients During and After Hospitalisation: a Prospective Repeated-Measures Cohort Study, Age and Ageing, 2020
Romero-Ortuno, R, Is phenotypical prefrailty all the same? Think again!, British Geriatrics Society Blog, 2020
Teodoro J. Oscanoa, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Román Romero-Ortuño, ANGIOTENSIN-CONVERTING ENZYME (ACE) GENETIC VARIATION AND LONGEVITY IN PERUVIAN OLDER PEOPLE: A CROSS-SECTIONAL STUDY, Annals of Human Biology, 2020
David Moloney, Roman Romero-Ortuno, Rose Anne Kenny, Letter to the editor in reponse to 'An Atypical Case of Vasovagal Cardioinhibitory Syncope in a Young Male Soldier-Stand Up, Be Counted. Doman, E.R., A.J. Kisling, and E. Fentanes, JAMA Internal Medicine, 2020', JAMA Internal Medicine, 2020
Chen Y, Dominguez-Vivero C, Almirall-Sanchez A, Oz D, Romero-Ortuno R, Hospital-associated deconditioning: brain health issues beyond physical factors, Alzheimer's Association International Conference (AAIC) 2020, Virtual, 2020
Macdonald S H-F, Travers J, Ní Shé É, Bailey J, Romero-Ortuno R, Keyes M, O'Shea D, Cooney MT, Primary care interventions to address physical frailty among community-dwelling adults aged 60 years or older: A meta-analysis, PLOS ONE, 2020
Hartley P, Dewitt AL, Forsyth F, Romero-Ortuno R, Deaton C, Predictors of physical activity in older adults early in an emergency hospital admission: a prospective cohort study, BMC Geriatrics, 2020
Oscanoa, T.J. and Romero-Ortuno, R. and Carvajal, A. and Savarino, A., A pharmacological perspective of chloroquine in SARS-CoV-2 infection: An old drug for the fight against a new coronavirus?, International Journal of Antimicrobial Agents, 56, (3), 2020
Evans NR, Wall J, To B, Wallis SJ, Romero-Ortuno R, Warburton EA, Clinical frailty independently predicts early mortality after ischaemic stroke, Age and Ageing, 2020
Íde O'Shaughnessy, Roman Romero-Ortuno, Lucinda Edge, Aoife Dillon, Sinéad Flynn, Robert Briggs, Darragh Shields, Geraldine McMahon, Arthur Hennessy, Una Kennedy, Paul Staunton, Rosa McNamara, Suzanne Timmons, Frances Horgan, Conal Cunningham, Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department, European Journal of Internal Medicine, 2020
Teodoro J. Oscanoa, Xavier Vidal, Jørgen K. Kanters, Roman Romero-Ortuno, Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: a Meta-analysis, International Journal of Antimicrobial Agents, 2020
Oscanoa, T.J. and Cieza, E.C. and Lizaraso-Soto, F.A. and Guevara, M.L. and Fujita, R.M. and Romero-Ortuño, R., Angiotensin-Converting Enzyme (ACE) genetic variation and longevity in Peruvian older people: a cross-sectional study, Annals of Human Biology, 47, (3), 2020, p309-312
Rónán O'Caoimh, Siobhán Kennelly, Emer Ahern, Shaun O'Keeffe, Román Romero Ortuño, Covid-19 and the challenges of frailty screening in older adults, Journal of Frailty and Ageing, 2020
Oscanoa, T.J. and Cieza, E.C. and Lizaraso-Soto, F.A. and Guevara, M.L. and Fujita, R.M. and Romero-Ortuno, R., Lack of association between angiotensin-converting enzyme (ACE) genotype and essential hypertension in Peruvian older people, Arterial Hypertension (Poland), 24, (3), 2020, p115-119
V.L. KEEVIL, A. LIOU, L. VAN DER POEL, S. WALLIS, R. ROMERO-ORTUNO, R. BIRAM, EMERGENCY HOSPITAL ADMISSIONS IN OLDER ADULTS FROM RESIDENTIAL AND NURSING HOMES: FREQUENCY, CHARACTERISTICS AND OUTCOMES, The Journal of Nursing Home Research Sciences, 2020
Oscanoa TJ, Romero-Ortuno R, Carvajal A, Savarino A, A pharmacological perspective of Chloroquine in SARS-CoV-2 infection, International Journal of Antimicrobial Agents, 2020
David Moloney, John O'Connor, Louise Newman, Siobhan Scarlett, Belinda Hernandez, Rose Anne Kenny, Roman RomeroOrtuno, Clinical clustering of eight orthostatic haemodynamic patterns in The Irish Longitudinal Study on Ageing (TILDA), European Geriatric Medicine, 16th International E-Congress of the European Geriatric Medicine Society, Virtual , 7-9 October 2020, 11, 2020, ppS117 - S118
Oscanoa, T.J. and Vidal, X. and Carvajal, A. and Amado, J. and Romero-Ortuno, R., Severity of SARS-COV-2 infection and angiotensin converting enzyme inhibitors and angiotensin receptor blockers: A meta-analysis, Arterial Hypertension (Poland), 24, (3), 2020, p106-114
Fiachra Maguire, Roman Romero-Ortuno, John D O'Connor, Richard B Reilly, Silvin P Knight, Rose-Anne Kenny, One-dimensional statistical parametric mapping identifies impaired orthostatic cerebrovascular and cardiovascular response in frailty index, The Journals of Gerontology, Series A Medical Sciences, 2020
Teodoro J. Oscanoa, Edwin C. Cieza, Frank A. Lizaraso-Soto, María L. Guevara, Ricardo M. Fujita, Roman Romero-Ortuno, LACK OF ASSOCIATION BETWEEN ANGIOTENSIN-CONVERTING ENZYME (ACE) GENOTYPE AND ESSENTIAL HYPERTENSION IN PERUVIAN OLDER PEOPLE, Arterial Hypertension, 2020
McCarthy K, Ward M, Romero-Ortuno R, Kenny RA, Syncope, fear of falling and quality of life among older adults: findings from The Irish Longitudinal Study on Ageing (TILDA), Frontiers in Cardiovascular Medicine, 2020
Knight, S.P.; Newman, L.; O'Connor, J.D.; Davis, J.; Kenny, R.A.; Romero-Ortuno, R., Associations between frailty phenotype and cardiovascular / neurovascular signal complexity, SFI Summit 2020, Virtual , 2020
Peeters G, Romero-Ortuno R, Lawlor B, Kenny RA, McHugh Power J, Clustering of behavioural symptoms and their associations with cognitive decline in older adults, JAMDA: Journal of the American Medical Directors Association, 2020
Romero-Ortuno R, Scarlett S, O'Halloran A, Kenny RA, Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in The Irish Longitudinal Study of Ageing (TILDA), Age and Ageing, 2019
Mobility and Frailty in, editor(s)Gu D, Dupre M , Encyclopedia of Gerontology and Population Aging, Springer, Cham, 2019, [Hartley P, Romero-Ortuno R]
Romero-Ortuno R, Kenny RA, McManus R, Collagens and elastin genetic variations and their potential role in aging-related diseases and longevity in humans, Experimental Gerontology, 129, 2019, p110781 -
Dent, E. and Martin, F.C. and Bergman, H. and Woo, J. and Romero-Ortuno, R. and Walston, J.D., Management of frailty: opportunities, challenges, and future directions, The Lancet, 394, (10206), 2019, p1376-1386
Frailty in older persons in, editor(s)O'Hanlon S, Smith M , A Comprehensive Guide to Rehabilitation of the Older Patient 4e, Elsevier, 2019, [Roe L, Williamson W, Romero-Ortuno R]
Teodoro J Oscanoa, Irene Andia M, Ociela Grimaldo, Edwin Cieza M, Frank Lizaraso Soto, Roman Romero Ortuno and Ricardo Fujita, Use of angiotensin II receptor blockers (ARBs), angiotensin I-converting enzyme (ACE) polymorphism and associations with memory performance in older people, Journal of Neurology & Neurophysiology, 2019
Romero-Ortuno R, Scarlett S, O'Halloran AM, Kenny RA., Is phenotypical prefrailty all the same? A longitudinal investigation of two prefrailty subtypes in TILDA., Age and ageing, 2019
Louise Lafortune, Joyce Coker, Rhian Simpson, Roman Romero-Ortuno, FRAILTY PROFILES: AN ANALYSIS OF ROUTINELY COLLECTED HOSPITAL DATA, The Journal of Frailty & Aging, 9th International Conference on Frailty & Sarcopenia Research (ICFSR) , Miami, USA, February 20-22, 2019, 2019
Hartley P, Costello P, Fenner R, Gibbins N, Quinn E, Kuhn I, Keevil VL, Romero-Ortuno R, Change in skeletal muscle associated with unplanned hospital admissions in adult patients: a systematic review and meta-analysis, PLOS One, 2019
Martin F, Romero-Ortuno R, Longitudinal studies of ageing: from insights to impacts: Commentary to accompany themed collection on longitudinal studies, Age and Ageing, 2019
Duggan E, Romero-Ortuno R, Kenny RA, Admissions for Orthostatic Hypotension: an Analysis of NHS England Hospital Episode Statistics Data, BMJ Open, 2019
K. M. Torsney, R. Romero-Ortuno, A SERVICE EVALUATION OF THE PERFORMANCE OF THE 4- AT AS A COGNITIVE SCREENING TOOL IN AN ENGLISH UNIVERSITY HOSPITAL, Age and Ageing, British Geriatrics Society Communications to the Autumn Meeting, London, 14-16 November 2018, 48, (Supplement_1), 2019
Pickard S, Lloyd L, Vanhoutte B, Danely J, Leon-Salas J, Laceulle H, Cluley V, Romero-Ortuno R, New Horizons in Frailty: the contingent, the existential and the clinical, Age and Ageing, 2019
Dent E, Martin FC, Bergman H, Woo J, Romero-Ortuno R, Walston J, The Management of Frailty: Opportunities, Challenges, and Future Directions, The Lancet, 2019
Lyons A, Romero-Ortuno R, Hartley P, Functional Mobility Trajectories of Hospitalized Older Adults Admitted to the Acute Geriatric Wards: A Retrospective Observational Study in an English University Hospital, Geriatrics and Gerontology International, 2019
Rivasi G, Kenny RA, Ungar A, Romero-Ortuno R, Effects of benzodiazepines on orthostatic blood pressure in older people, European Journal of Internal Medicine, 2019
Rivasi G, Kenny RA, Ungar A, Romero-Ortuno R, Predictors of incident fear of falling in community-dwelling older adults, Journal of the American Medical Directors Association, 2019
Oscanoa TJ, Amado JP, Romero-Ortuno R, Hidalgo JA, Estimation of the glomerular filtration rate in older individuals with serum creatinine-based equations: A systematic comparison between CKD-EPI and BIS1, Archives of Gerontology and Geriatrics , 75, 2018, p139 - 145
Romero-Ortuno R, Forsyth DR, Frailty, the determinants of health and the new evidence base, Aging Medicine, 2018, p1 - 2
O'Connell, M.D. and Savva, G.M. and Finucane, C. and Romero-Ortuno, R. and Fan, C.W. and Kenny, R.A., Impairments in Hemodynamic Responses to Orthostasis Associated with Frailty: Results from The Irish Longitudinal Study on Ageing (TILDA), Journal of the American Geriatrics Society, 66, (9), 2018, p1475-1483
Keevil VL, Martin GJ, Biram R, Wallis S, Romero-Ortuno R, Care home residents admitted to hospital through the emergency pathway: characteristics and associations with inpatient mortality, Journal of the Royal College of Physicians of Edinburgh, 48, 2018, p202 - 209
Stubbs D, Bowen J, Murray R, Gilder F, Romero-Ortuno R, Biram R, Menon D, Ercole A, Development and validation of an electronic postoperative morbidity score (EPOMS), Anesthesia & Analgesia, 2018
Torsney KM, Romero-Ortuno R, The Clinical Frailty Scale predicts inpatient mortality in older hospitalised patients with idiopathic Parkinson's disease, The Journal of the Royal College of Physicians of Edinburgh, 48, (2), 2018, p103 - 107
Alabaf Sabbaghi S, De Souza D, Sarikonda P, Keevil VL, Wallis SJ, Romero-Ortuno R, Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team, Aging Medicine, 2018, p1 - 5
Weichert I, Romero-Ortuno R, Tolonen J, Soe T, Lebus C, Choudhury S, Nadarajah CV, NAnayakkara P, Orru M, Di Somma S, Anticholinergic medications in patients admitted with cognitive impairment and falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multi centre observational study, Journal of Clinical Pharmacy and Therapeutics, 43, (5), 2018, p682 - 694
Torsney, K.M. and Romero-Ortuno, R., The clinical frailty scale predicts inpatient mortality in older hospitalised patients with idiopathic parkinsonâ s disease, Journal of the Royal College of Physicians of Edinburgh, 48, (2), 2018, p103-107
Moore G, Hartley P, Romero-Ortuno R, Health and social factors associated with a delayed discharge amongst inpatients in acute geriatric wards: A retrospective observational study, Geriatrics and Gerontology International, 18, (4), 2018, p530 - 537
Amblàs-Novellas J, Martori JC, Espaulella J, Oller R, Molist-Brunet N, Inzitari M, Romero-Ortuno R , Frail-VIG index: a concise frailty evaluation tool for rapid geriatric assessment, BMC Geriatrics , 18, 2018, p29-
Hartley P, Keevil VL, Westgate K, White T, Brage S, Romero-Ortuno R, Deaton C, Using Accelerometers to Measure Physical Activity in Older Patients Admitted to Hospital, Current Gerontology and Geriatrics Research, 2018
Travers J., Romero-Ortuno R., Bailey J., Cooney M.T., Delaying and reversing frailty: a systematic review of primary care interventions, British Journal of General Practice, 2018
Kenny R.A, Romero-Ortuno R, Kumar P, Falls in older adults, Medicine (United Kingdom), 45, (1), 2017, p28 - 33
Hartley PJ, Keevil VL, Alushi L, Charles RL, Conroy EB, Costello PM, Dixon B, Dolinska-Grzybek AM, Vajda D, Romero-Ortuno R, Earlier physical therapy input is associated with a reduced length of hospital stay and reduced care needs on discharge in frail older inpatients: an observational study, Journal of Geriatric Physical Therapy , 2017
Contra-Carné A, Romero-Ortuno R, Frailty screening in the acute hospital: evidence and challenges based on an English experience, Revista Multidisciplinar de Gerontología , 22, 2017
Induruwa IP, Evans NR, Aziz A, Reddy S, Khadjooi K, Romero-Ortuno R, Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation, Geriatrics and Gerontology International , 17, (11), 2017, p2178 - 2183
Hartley P, Alexander K, Adamson J, Cunningham C, Embleton G, Romero-Ortuno R, Association of cognition with functional trajectories in patients admitted to geriatric wards: a retrospective observational study, Geriatrics and Gerontology International , 17, (10), 2017, p1438 - 1443
Hartley P, Gibbins N, Saunders A, Alexander K, Conroy E, Dixon R, Lang J, Luckett J, Luddington T, Romero-Ortuno R, The association between cognitive impairment and functional outcome in hospitalised older patients: a systematic review and meta-analysis, Age and Ageing , 46, (4), 2017, p559 - 567
Hartley P, Keevil VL, Romero-Ortuno R, The association between clinical frailty and walking speed in older hospitalised medical patients: a retrospective observational study, European Geriatric Medicine , 8, (2), 2017, p130 - 133
Romero-Ortuno R, Forsyth DR, Wilson KJ, Cameron E, Wallis S, Biram R, Keevil VL, The association of geriatric syndromes with hospital outcomes, Journal of Hospital Medicine , 12, (2), 2017, p83 - 89
Amblàs-Novellas J, Espaulella-Panicot J, Inzitari M, Rexach L, Fontecha B, Romero-Ortuno R, The challenge of clinical complexity in the 21st century: could frailty indices be the answer?, Spanish Journal of Geriatrics and Gerontology, 52, (3), 2017, p159 - 166
Hartley P, Adamson J, Cunningham C, Embleton G, Romero-Ortuno R, Clinical frailty and functional trajectories in hospitalized older adults: a retrospective observational study, Geriatrics and Gerontology International , 17, (7), 2017, p1063 - 1068
Amblà s-Novellas, J. and Espaulella-Panicot, J. and Inzitari, M. and Rexach, L. and Fontecha, B. and Romero-Ortuno, R., The challenge of clinical complexity in the 21st century: Could frailty indexes be the answer? [En busca de respuestas al reto de la complejidad clÃnica en el siglo XXI: a propósito de los Ãndices de fragilidad], Revista Espanola de Geriatria y Gerontologia, 52, (3), 2017, p159-166
Oscanoa, T., Romero-Ortuno, R., Cruz-Jentoft, A., Negative stereotypes associated with frailty in the elderly, Revista Espanola de Geriatria y Gerontologia, 2016
Hawker, M., Romero-Ortuno, R., Social Determinants of Discharge Outcomes in Older People Admitted to a Geriatric Medicine Ward, The Journal of frailty & aging, 5, (2), 2016, p118-120
Fleming, J., Farquhar, M., Brayne, C., Barclay, S., Buck, J., Dening, T., Hunter, S., Mukaetova-Ladinska, E., O'Sullivan, A., Paykel, E., Romero-Ortuno, R., Zhao, J.E., Death and the oldest old: Attitudes and preferences for end-of-life care - Qualitative research within a population-based cohort study, PLoS ONE, 11, (4), 2016
Disorders of the Autonomic Nervous System (Chapter 63) in, editor(s)Fillit HM, Rockwood K, Woodhouse K , Brocklehurst's Textbook of Geriatric Medicine and Gerontology, 8th Edition, 2016, pp496 - 509, [Romero-Ortuno R, Wilson KJ, Hampton JL]
Hartley, P., Adamson, J., Cunningham, C., Embleton, G., Romero-Ortuno, R., Higher Physiotherapy Frequency Is Associated with Shorter Length of Stay and Greater Functional Recovery in Hospitalized Frail Older Adults: A Retrospective Observational Study, The Journal of frailty & aging, 5, (2), 2016, p121-125
Romero-Ortuno R, Wallis S, Biram R, Keevil VL, Clinical frailty adds to acute illness severity in predicting mortality in hospitalised older adults: an observational study, European Journal of Internal Medicine, 35, 2016, p24 - 34
Oscanoa, T. and Romero-Ortuno, R. and Cruz-Jentoft, A., Negative stereotypes associated with frailty in the elderly [Estereotipos negativos asociados a la fragilidad en personas mayores], Revista Espanola de Geriatria y Gerontologia, 51, (4), 2016, p225-228
Wallis SJ, Wall J, Biram RW, Romero-Ortuno R, Association of the clinical frailty scale with hospital outcomes., QJM : monthly journal of the Association of Physicians, 108, (12), 2015, p943-9
Martínez-Velilla, N., Romero-Ortuño, R., Frailty: Yes, but let's avoid 'frailtism' | Fragilidad: Sí, pero evitemos el «fragilismo», Revista Espanola de Geriatria y Gerontologia, 50, (5), 2015, p209-210
Romero-Ortuno R, Frailty in Primary Care., Interdisciplinary topics in gerontology and geriatrics, 41, 2015, p85-94
Keevil VL, Romero-Ortuno R, Ageing well: a review of sarcopenia and frailty., The Proceedings of the Nutrition Society, 74, (4), 2015, p337-47
Chan DKY, Srinivasan V, Upton C, Chen X, Romero-Ortuno R, The association between frailty and vascular dementia, Chinese Journal of Geriatrics , 34, (12), 2015, p1293 - 1299
Romero-Ortuno R1, O'Connell MD, Finucane C, Fan CW, Kenny RA, Higher orthostatic heart rate predicts mortality: The Irish Longitudinal Study on Ageing (TILDA), Aging Clin Exp Res, 27, (2), 2015, p239-242
Kennelly SP, Drumm B, Coughlan T, Collins R, O'Neill D, Romero-Ortuno R, Characteristics and outcomes of older persons attending the emergency department: a retrospective cohort study., QJM, 2014
Romero-Ortuno R, Frailty Index in Europeans: association with determinants of health., Geriatrics & gerontology international, 14, (2), 2014, p420-9
Ntlholang O, Kelly RE, Romero-Ortuno R, Cosgrave S, Kelly D, Crowe M, Collins O, Barry JJ, Cogan L, Hughes G, O'Shea D, The role the frailty syndrome can play in advocacy and resource allocation for our ageing population - findings in a Dublin day hospital, The Journal of Frailty and Aging, 3, (1), 2014, p21 - 24
BMC Geriatrics, BMC, [Associate Editor (public health, nutrition and epidemiology)], 2014-2019
Reynaud C, McHugh T, Romero-Ortuno R, Frailty: what does it mean for clinical care provision? , Scottish Universities Medical Journal , 3, (1), 2014, p54 - 64
Grace AR, Briggs R, Kieran RE, Corcoran RM, Romero-Ortuno R, Coughlan TL, O'Neill D, Collins R, Kennelly SP, A Comparison of Beers and STOPP Criteria in Assessing Potentially Inappropriate Medications in Nursing Home Residents Attending the Emergency Department., Journal of the American Medical Directors Association, 2014
Romero-Ortuno R, Fouweather T, Jagger C, Cross-national disparities in sex differences in life expectancy with and without frailty., Age and ageing, 43, (2), 2014, p222-8
Romero-Ortuno R, Soraghan C, A Frailty Instrument for primary care for those aged 75 years or more: findings from the Survey of Health, Ageing and Retirement in Europe, a longitudinal population-based cohort study (SHARE-FI75+)., BMJ open, 4, (12), 2014, pe006645
Romero-Ortuno R, Tiernan C, Cogan L, The impact of frailty on post-acute rehabilitation outcomes in older adults, The Journal of Frailty and Aging , 3, (4), 2014, p234 - 237
Romero-Ortuno, R., O'Dwyer, C., Byrne, D., O'Riordan, D., Silke, B., A Risk Index for Geriatric Acute Medical Admissions (RIGAMA), Acute Med, 13, (1), 2014, p6-11
Romero-Ortuno, R., Silke, B., Use of a laboratory only score system to define trajectories and outcomes of older people admitted to the acute hospital as medical emergencies, 13, (2), 2013, p405-412
Romero-Ortuno R, An alternative method for Frailty Index cut-off points to define frailty categories., European geriatric medicine, 4, (5), 2013
Romero-Ortuno, R, O'Connell, MDL, Finucane, C, Soraghan, C, Fan, CW, Kenny, RA, Insights into the clinical management of the syndrome of supine hypertension - orthostatic hypotension (SH-OH): The Irish Longitudinal Study on Ageing (TILDA), BMC Geriatrics, 13, 2013, p73-
Romero-Ortuno R, The SHARE operationalized frailty phenotype: a comparison of two approaches., European geriatric medicine, 4, (4), 2013
Romero-Ortuno, R., O'Shea, D., Fitness and frailty: Opposite ends of a challenging continuum! Will the end of age discrimination make frailty assessments an imperative?, 42, (3), 2013, p279-280
Romero Ortuño, R., Formiga, F., Fitness or frailty? Does age matter? New horizons in geriatrics | "Fortaleza o fragilidad? "Importa la edad? Nuevos horizontes en geriatría, 48, (5), 2013, p207-208
Back to basics or into a brave new world? The potential and pitfalls of biomarkers in explaining the pathways between social engagement and health in, editor(s)Hoque, N., McGehee, M.A. and Bradshaw, B.S. (eds) , Applied demography and public health [Applied demography series volume 3], New York, Springer, 2013, pp313 - 336, [Kamiya, Y., Timonen, V., Romero-Ortuno, R. and Kenny, R.A.]
Romero-Ortuno R, The Frailty Instrument for primary care of the Survey of Health, Ageing and Retirement in Europe predicts mortality similarly to a frailty index based on comprehensive geriatric assessment., Geriatrics & gerontology international, 13, (2), 2013, p497-504
Romero-Ortuno, R., Tempany, M., Dennis, L., O'Riordan, D., Silke, B., Deprivation in cold weather increases the risk of hospital admission with hypothermia in older people, 182, (3), 2013, p513-518
Kenny, R.A., Romero-Ortuno, R., Cogan, L, Falls, Medicine, 41, (3), 2013, p155-159
Romero-Ortuno R, Kenny RA., The frailty index in Europeans: assocation with age and mortality., Age Ageing, 41, (Sep), 2012, p684 - 689
Romero-Ortuno, R., O'Shea, D., Silke, B., Predicting the in-patient outcomes of acute medical admissions from the nursing home: The experience of St James's Hospital, Dublin, 2002-2010, 12, (4), 2012, p703-713
Romero-Ortuno, R., O'Riordan, D., Silke, B., Profiling the medical admissions of the homeless, 11, (4), 2012, p197-204
Romero-Ortuno, R., O'Shea, D., Aspirin versus warfarin in atrial fibrillation: Decision analysis may help patients' choice, 41, (2), 2012, p250-254
Romero-Ortuno R, Kenny RA., The frailty index in Europeans: association with age and mortality., Age and Ageing, afs051, 2012, p684-689
Ni Mhaolain AM, Fan CW, Romero-Ortuno R, Cogan L, Cunningham C, Kenny RA, Lawlor B., Frailty, depression and anxiety in later life., International Psychogeriatrics, 24, (8), 2012, p1265 - 1274
Ni Mhaolain AM, Fan CW, Romero-Ortuno R, Cogan L, Cunningham C, Lawlor B, Kenny RA., Depression: a modifiable factor in fearful older fallers transitioning to frailty?, International Journal of Geriatric Psychiatry , 27, (7), 2012, p727 - 733
Romero-Ortuno R, Cogan L, Browne J, Healy M, Casey MC, Cunningham C, Walsh JB, Kenny RA, Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people., Age and ageing, 40, (2), 2011, p168-74
Romero Ortuño, R., The Frailty Instrument for primary care of the Survey of Health, Ageing and Retirement in Europe (SHARE-FI): Results of the Spanish sample | El Instrumento de Fragilidad para Atención Primaria de la Encuesta de Salud, Envejecimiento y Jubilación en Europa (SHARE-FI): resultados de la muestra española, 46, (5), 2011, p243-249
Romero-Ortuno R, Cogan L, O'Shea D, Lawlor BA, Kenny RA, Orthostatic haemodynamics may be impaired in frailty., Age and Ageing, 40, (5), 2011, p576-83
Romero-Ortuno R, Casey AM, Cunningham CU, Squires S, Prendergast D, Kenny RA, Lawlor BA, Psychosocial and functional correlates of nutrition among community-dwelling older adults in Ireland, Journal of Nutrition, Health and Aging , 15, (7), 2011, p527-531
R Romero-Ortuno, L Cogan, T Foran, RA Kenny, CW Fan., Continuous noninvasive orthostatic blood pressure measurements and their relationship with orthostatic intolerance, falls, and frailty in older people., Journal of the American Geriatrics Society, 59, (4), 2011, p655-65
Romero-Ortuno R, O'Shea D, Kenny RA., The SHARE frailty instrument for primary care predicts incident disability in a European population-based sample., Quality in Primary Care , 19, (5), 2011, p301 - 309
Romero-Ortuno, R., The frailty instrument of the survey of health, ageing and retirement in Europe (SHARE-FI) predicts mortality beyond age, comorbidities, disability, self-rated health, education and depression, 2, (6), 2011, p323-326
Romero-Ortuno, R., Walsh, C.D., Lawlor, B.A., Kenny, R.A., A Frailty Instrument for primary care: Findings from the Survey of Health, Ageing and Retirement in Europe (SHARE), BMC Geriatrics, 10, 2010
Romero-Ortuno R, Cogan L, Fan CW, Kenny RA., Intolerance to initial orthostasis relates to systolic BP changes in elders., Clin Auton Res., 20, (1), 2010, p39 - 45
Kenny RA, Romero-Ortuno R, Cogan L., Falls., Medicine., 37, (2), 2010, p84 - 87
Romero Ortuño, R., The regulation of pedestrian traffic lights in Spain: Do older people have enough time to cross the road? | La regulación de los semáforos peatonales en España: "tienen las personas mayores tiempo suficiente para cruzar?, 45, (4), 2010, p199-202
Romero-Ortuno, R., Frailty: The great confounder, the great forgotten, 96, (7), 2010
Romero-Ortuno, R, Cogan, L, Cunningham, CU, Kenny, RA, Do older pedestrians have enough time to cross roads in Dublin? A critique of the Traffic Management Guidelines based on clinical research findings, AGE AND AGEING, 39, 2010
Romero-Ortuno, R, Cogan, L, Foran, T, Fan, CW, Kenny, RA, Using the Finometer to examine sex differences in hemodynamic responses to orthostasis in older people, BLOOD PRESSURE MONITORING, 15, 2010
Greene BR, O'Donovan A, Romero-Ortuno R, Cogan L, Ni Scannaill C, Kenny RA., Quantitative falls risk assessment using the timed up and go test., IEEE Transactions on Biomedical Engineering., 57, (12), 2010, p2918 - 2926
Romero-Ortuno R, Ageing and Social Policy in Ireland, Journal of Social Policy , 38, 2009, p714 - 716
Romero-Ortuno R, Kenny RA, Is it cardiac? Assessment of syncope with a scoring system., HEART, 94, (12), 2008, p1528 - 1529
Romero-Ortuño, R., Access to health care for illegal immigrants in the EU: Should we be concerned?, European Journal of Health Law, 11, (3), 2004, p245-272
Romero-Ortuno R, Eligibility of non-residents for NHS treatment: failed asylum seekers should not be denied access to free NHS care., BMJ (Clinical research ed.), 329, (7467), 2004, p683
Romero-Ortuno, R. and Noglik, A. and Bassi, Z. and Snelling, S. and Kersnik, J. and O'Conor, R. and O'Farrell, N. and Ash, S. and Fox, P. and Lynn, W., Eligibility of non-residents for NHS treatment [1] (multiple letters), British Medical Journal, 329, (7467), 2004, p683-684
Non-Peer-Reviewed Publications
Eoin Duggan, Glenn Jennings, Ann Monaghan, Lisa Byrne, Feng Xue, Roman Romero-Ortuno, Characterising the Blood Pressure Response to Physical Counterpressure Manoeuvres Using Surface Electromyography in Adults with Long Covid, TechRxiv, 2023
Silvin P. Knight, Jose Refojo, Louise Newman, Rossella Rizzo, Hugh Tinney, Roman Romero-Ortuno, "Dancing with Atoms": A tribute to Sheila Tinney, Research Square, 2023
Ann Monaghan, Nollaig Bourke, Aisling O'Halloran, Mark Ward, Feng Xue, Glenn Jennings, Rose Anne Kenny and Roman Romero-Ortuno, New self-reported exhaustion during the COVID-19 Pandemic, TILDA Report, 2021
Aisling O'Halloran, Roman Romero-Ortuno, How can frailty impact access to health and social care services?, HRB Open Research Blog, November, 2021
Roman Romero-Ortuno, Peter May, Minjuan Wang, Siobhan Scarlett, Ann Hever, Rose Anne Kenny, TILDA Nursing Home Data: A short report to inform COVID-19 responses for our most vulnerable, The Irish Longitudinal Study on Ageing, 2020
Romero-Ortuño R and Kennelly SP, COVID-19 deaths in Irish Nursing Homes: exploring variation and association with the adherence to national regulatory quality standards, LTCcovid.org, International Long-Term Care Policy Network,, CPEC-LSE, June, 2020
Oscanoa TJ, Vidal X, Carvajal A, Romero-Ortuno R, Renin-angiotensin system inhibitors and severity of SARS-CoV-2 infection: a meta-analysis, Research Square (Preprint), 2020
Aisling O'Halloran, Christine McGarrigle, Siobhan Scarlett, Lorna Roe, Roman Romero-Ortuno and Rose Anne Kenny, TILDA Report on Population Estimates of Physical Frailty in Ireland to Inform Demographics for Over 50s in Ireland during the COVID-19 Pandemic, Dublin, The Irish Longitudinal Study on Ageing, Trinity College Dublin, 2020
Roman Romero-Ortuno, Peter May, Minjuan Wang, Siobhán Scarlett, Ann Hever and Rose Anne Kenny, TILDA Participants in Nursing Homes, TILDA, Trinity College Dublin, 2020
Aisling O'Halloran, Christine McGarrigle, Siobhán Scarlett, Lorna Roe, Mary O'Shea, Roman Romero-Ortuno and Rose Anne Kenny, Living with Frailty in Ireland 2018, TILDA, Trinity College Dublin, 2020
eee, eee, 2012
McCartan B, Editorial, Journal of the Irish Dental Association, 21, 1975, p120 - 121
Research Expertise
Projects
- Title
- FRAILMatics: Mathematical research and big data analytics towards the development of the next generation of transdisciplinary diagnostics for the assessment of physiological vulnerability in older adults: challenge-based disruptive technology initiative
- Summary
- https://tilda.tcd.ie/frailmatics/ Increasing numbers of older people are living with frailty. Frailty is defined as dysregulation in multiple physiological systems and consequent reduction in physiological reserve. A frail person is vulnerable to decompensate and experience adverse health outcomes in the face of stressors. The higher the number of physiological systems that are dysregulated, the less physiological reserve. Despite consensus in the concept, frailty operationalisations in clinical practice are limited and a universally accepted diagnostic method does not exist. However, there is evidence that early recognition of frailty could prevent or delay adverse outcomes. The Irish Longitudinal Study on Ageing (TILDA) has collected detailed information on real-time functioning of physiological systems, with and without challenge: neurological (choice reaction time, sustained attention to response task, cerebral blood flow before and after standing), cardiovascular (continuous blood pressure and heart rate, before and after standing), and locomotor (gait with and without cognitive challenges). For this research, TILDA will offer the opportunity to host infrastructure and capacity in mining, processing and modelling its largely unexplored complex and computationally expensive "big data". We aim to discover new frailty signals and models, validate them in clinical cohorts, and lead towards new diagnostic tools to help tackle the ageing challenge.
- Funding Agency
- Science Foundation Ireland
- Date From
- 01/12/2019
- Date To
- 30/11/2024
- Title
- Technology Assisted Solutions for the Recognition of Objective Physiological Indicators of post-COVID-19 Fatigue (TROPIC Study)
- Summary
- Many COVID-19 patients are experiencing symptoms consistent with severe fatigue a median of 10 weeks after their initial illness, while almost one-third of those previously employed have not returned to work. At present, most clinical and research measurements of fatigue have relied upon self-reported perception of sensations such as exhaustion or weariness. Using such tools, there is an inherent challenge for clinicians in differentiating between patients who are experiencing fatigue at a psychosocial level, versus those who are actively physiologically and neurocognitively deconditioned.The TROPIC study will use our existing clinical expertise and technology-assisted solutions to address features of post-COVID-19 fatigue by quantifying physiological signatures of adverse sequelae in adult patients previously diagnosed with COVID-19, who are now COVID-19 negative. Our suite of assessments will encompass four systems; physical deconditioning, orthostatic instability, neurocognitive deficits and respiratory sequelae. This will not only inform accurate objective diagnostics of post-COVID-19 Chronic Fatigue Syndrome, but will also guide clinicians in directing the most appropriate therapeutic interventions with maximum efficacy and specificity, bringing not only patient-related but also health system and economic benefits.
- Funding Agency
- Science Foundation Ireland
- Date From
- 1 December 2020
- Date To
- 31 January 2021
- Title
- FRAIL-INNATE Pilot Study: Investigating the Impact of Frailty on Innate Immune Responses
- Summary
- Older adults and those living with frailty (a condition of decreased physiological reserve affecting multiple systems) get higher rates of viral infections, most recently exemplified during the COVID-19 pandemic, where highest mortality is in older individuals and those with severe frailty. Yet older adults and those with frailty are not a homogenous group, and it is still unknown which individuals are most at risk from viral infections and why. There is therefore a fundamental lack of understanding in how increasing age and states of frailty affects anti-viral immunity and how this relates to frailty-associated changes in metabolic health (body composition, energy expenditure) - important influences on anti-viral responses in younger adults, yet remains unexplored in older adults. We hypothesise that by analysing the metabolic status of older adults in different states of frailty, and linking this with how their immune system activates anti-viral immunity, we will reveal crucial insights into anti-viral immunity in older and frail adults. The FRAIL-INNATE Pilot Study builds on the expertise of this clinician-scientist team (Prof. Roman Romero-Ortuno, Dr Nollaig Bourke, Dr Adam Dyer) and will be the first of its kind to address this hypothesis using a standardized method of characterizing innate immune responses in older adults across the frailty spectrum.
- Funding Agency
- TTMI Collaborative Pilot Study Awards - Building Engagements in Health Research 2020
- Date From
- May 2021
- Date To
- May 2023
- Title
- NUTRI-AGE: NOVEL DIETARY COMPONENTS IN HEALTHY AGEING
- Summary
- The overarching aim of Nutri-Age is to investigate whether higher intakes of alkali-forming compounds present in fruit and vegetables, which are known to attenuate low grade metabolic acidosis, can protect against adverse agerelated changes in skeletal muscle, bone and metabolic health. Objectives: 1) To examine the impact of correcting age-related metabolic acidosis, via nutritional supplementation with the fruit- and vegetable-derived alkaline salt potassium citrate, on skeletal muscle protein synthesis, bone turnover and insulin sensitivity 2) To examine whether diets that are richer in fruit and vegetables (and are therefore lower in dietary acid load and less likely to induce low grade metabolic acidosis) are associated with a slower rate of decline in muscle strength, physical function, frailty status, bone density and glycaemic control in older adults in Ireland. 3) To examine food choice motivation and attitudes towards functional / fortified foods targeted at healthy ageing among older adults via an online survey (Awardee: Dr Caoileann Murphy).
- Funding Agency
- Tegasc
- Date From
- 18th March 2021
- Date To
- 17 March 2024
- Title
- Neurocardiovascular instability as a risk factor for progression of Age-related Macular degeneration
- Summary
- Age-related macular degeneration (AMD) is the leading cause of vision loss in the over 50's in developed countries accounting for 8.7% of all blindness worldwide. In Ireland alone, ~80,000 people live with this condition. AMD is a progressive disease characterised in early stages by drusen deposition and pigmentary changes, which progresses to late stage geographic atrophy and choroidal neovascularisation. To date, treatment options are limited to late neovascular AMD, while preventative measures such as smoking cessation and increased supplement intake are advised for early and late geographic AMD. Multifactorial in nature, AMD has no defined aetiology, however several environmental and genetic factors have been identified as associated with increased incidence and progression. Neurocardiovascular instability (NCVI) which comprises of age-related changes in blood pressure and heart-rate behaviour manifests as exaggerated blood pressure variability, orthostatic hypotension (OH), orthostatic hypertension (OHTN), and autonomic dysfunction, and has been implicated in cardiovascular risk and associated end-organ damage. Evidence suggests a link between AMD and cardiovascular disease (CVD), with several AMD risk factors also found to be associated with CVD, suggesting that disordered circulation may be a common factor in both conditions. The eye being a highly vascular organ consisting of retinal and choroidal vascular beds, would be vulnerable to NCVI if ocular vasoregulation becomes impaired with age. Indeed, associations between OHTN and BPV and increased AMD risk and poor visual acuity have been established, suggesting the deleterious effect of dysregulated blood pressure behaviour on choroidal circulation may be linked to AMD pathogenesis and progression. In the proposed study we will utilize The Irish Longitudinal study on Ageing (TILDA) dataset to examine measures of visual function and AMD status with cardiovascular/cerebrovascular function and advanced haemodynamic parameters, in this population representative cohort of participants aged ≥50 years, in an effort to establish associations between NCVI and AMD and predictors of AMD progression (Awardee: Dr Emma Connolly).
- Funding Agency
- Irish Research Council
- Date From
- 1 September 2021
- Date To
- 31 August 2023
- Title
- A Genome-Wide Association Study (GWAS) of biological age measures in UK Biobank, with a focus on genetic variations of collagens, elastin and pro-inflammatory cytokines
- Summary
- https://www.ukbiobank.ac.uk/2019/07/a-genome-wide-association-study-gwas-of-biological-age-measures-in-uk-biobank-with-a-focus-on-genetic-variations-of-collagens-elastin-and-pro-inflammatory-cytokines/
- Funding Agency
- Trinity Translational Medicine Institute
- Date From
- March 2019
- Date To
- December 2020
Recognition
Awards and Honours
School Award for Teaching Excellence
Fellowship of Trinity College Dublin
Master in Arts (jure officii), Trinity College Dublin
President of Ireland Future Research Leaders Award
Count of Cartagena Award of the Royal National Academy of Medicine of Spain
First Prize of the Catalan Society of Geriatrics and Gerontology
British Geriatrics Society Rising Star Award
Elizabeth Brown Prize of the British Geriatrics Society
Trainee Prize, Royal Society of Medicine (Geriatrics and Gerontology Section)
Presidential Medal of the Irish Gerontological Society
Loch Exhibition, University of London
Titmuss Examination Prize (Department of Social Policy, London School of Economics and Political Science)
Memberships
Irish Gerontological Society
Irish Society of Physicians in Geriatric Medicine
Royal College of Physicians of Ireland
Irish Frailty Network for Education, Quality Improvement, Research and Policy
UEMS -Geriatric Medicine section (European Union of Medical Specialists)
EuGMS Executive Board, Director for Education & Training
Neuroscience Ireland Council