Biography
Patrick Mitchell is a senior lecturer/associate professor of medicine and respiratory consultant physician at Trinity College Dublin and Tallaght University Hospital. Graduating from UCD in 2007 with a medical degree he specialised in internal medicine and respiratory medicine. He undertook a two-year clinical and research fellowship at McMaster University under which entailed translational research in airway inflammation and servicing both general respiratory and airway inflammation clinics. He also completed a two-year Medical Doctorate thesis on the role of IL-33 in allergic asthma. Following his fellowship he was appointed clinical assistant professor of medicine at the University of Calgary, Canada where he was director of the airways disease unit. He returned to Ireland to the above mentioned role with his wife and three children. He has authored numerous peer reviewed research manuscripts and co-authored a book chapter on asthma. Dr. Mitchell's clinical interests are in asthma, Chronic Obstructive Pulmonary Disease (COPD), chronic eosinophilic airways disease, autoimmune pulmonary diseases, Sarcoidosis.
Publications and Further Research Outputs
Peer-Reviewed Publications
Denton E, Hew M, Peters MJ, Upham JW, Bulathsinhala L, Tran TN, Martin N, Bergeron C, Al-Ahmad M, Altraja A, Larenas-Linnemann D, Murray R, Celis-Preciado CA, Al-Lehebi R, Belhassen M, Bhutani M, Bosnic-Anticevich SZ, Bourdin A, Brusselle GG, Busby J, Canonica GW, Heffler E, Chapman KR, Charriot J, Christoff GC, Chung LP, Cosio BG, Côté A, Costello RW, Cushen B, Fingleton J, Fonseca JA, Gibson PG, Heaney LG, Huang EW, Iwanaga T, Jackson DJ, Koh MS, Lehtimäki L, Máspero J, Mahboub B, Menzies-Gow AN, Mitchell PD, Papadopoulos NG, Papaioannou AI, Perez-de-Llano L, Perng DW, Pfeffer PE, Popov TA, Porsbjerg CM, Rhee CK, Roche N, Sadatsafavi M, Salvi S, Schmid JM, Sheu CC, Sirena C, Torres-Duque CA, Salameh L, Patel PH, Ulrik CS, Wang E, Wechsler ME, Price DB, ISAR LUMINANT Working Group., Real-world biologics response and super-response in the International Severe Asthma Registry cohort., Allergy, 2024
Scelo G, Torres-Duque CA, Maspero J, Tran TN, Murray R, Martin N, Menzies-Gow AN, Hew M, Peters MJ, Gibson PG, Christoff GC, Popov TA, Côté A, Bergeron C, Dorscheid D, FitzGerald JM, Chapman KR, Boulet LP, Bhutani M, Sadatsafavi M, Jiménez-Maldonado L, Duran-Silva M, Rodriguez B, Celis-Preciado CA, Cano-Rosales DJ, Solarte I, Fernandez-Sanchez MJ, Parada-Tovar P, von Bülow A, Bjerrum AS, Ulrik CS, Assing KD, Rasmussen LM, Hansen S, Altraja A, Bourdin A, Taille C, Charriot J, Roche N, Papaioannou AI, Kostikas K, Papadopoulos NG, Salvi S, Long D, Mitchell PD, Costello R, Sirena C, Cardini C, Heffler E, Puggioni F, Canonica GW, Guida G, Iwanaga T, Al-Ahmad M, Linnemann DL, Garcia U, Kuna P, Fonseca JA, Al-Lehebi R, Koh MS, Rhee CK, Cosio BG, de Llano LP, Perng Steve DW, Huang EW, Wang HC, Tsai MJ, Mahboub B, Salameh LIJ, Jackson D, Busby J, Heaney LG, Pfeffer P, Goddard AG, Wang E, Hoyte F, Wechsler ME, Chapman N, Katial R, Carter V, Bulathsinhala L, Eleangovan N, Ariti C, Lyu J, Price DB, Porsbjerg C., Analysis of comorbidities and multimorbidity in adult patients in the International Severe Asthma Registry., Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 132, (1), 2024, p42-53
O'Brien S, Musameh K, El Obeid M, Butler T, Armstrong M, Cunningham Z, Atzinger A, Kuwert T, Mitchell PD, Donnelly SC., Fibroblast activation in sarcoidosis as assessed by 68Ga-FAPI (fibroblast activation protein inhibitor)-46 PET/CT., QJM : monthly journal of the Association of Physicians, 2024, phcae067
Bourdin A, Brusselle G, Couillard S, Fajt ML, Heaney LG, Israel E, McDowell PJ, Menzies-Gow A, Martin N, Mitchell PD, Petousi N, Quirce S, Schleich F, Pavord ID., Phenotyping of Severe Asthma in the Era of Broad-Acting Anti-Asthma Biologics., The journal of allergy and clinical immunology. In practice, 12, (4), 2024, p809-823
Gauvreau GM, Sehmi R, FitzGerald JM, Leigh R, Cockcroft DW, Davis BE, Mayers I, Boulet LP, Al-Sajee D, Salter BM, Cusack R, Ho T, Whetstone C, Alsaji N, Satia I, Killian KJ, Mitchell PD, Magee IP, Bergeron C, Bhutani M, Werkström V, Dur"y"ski T, Shoemaker K, Katial RK, Jison M, Newbold P, McCrae C, O'Byrne PM., Benralizumab for allergic asthma: a randomised, double-blind, placebo-controlled, trial., The European respiratory journal, 2024, p2400512
Wechsler ME, Scelo G, Larenas-Linnemann DES, Torres-Duque CA, Maspero J, Tran TN, Murray RB, Martin N, Menzies-Gow AN, Hew M, Peters MJ, Gibson PG, Christoff GC, Popov TA, Côté A, Bergeron C, Dorscheid D, FitzGerald JM, Chapman KR, Boulet LP, Bhutani M, Sadatsafavi M, Jiménez-Maldonado L, Duran-Silva M, Rodriguez B, Celis-Preciado CA, Cano-Rosales DJ, Solarte I, Fernandez-Sanchez MJ, Parada-Tovar P, von Bülow A, Bjerrum AS, Ulrik CS, Assing KD, Rasmussen LM, Hansen S, Altraja A, Bourdin A, Taille C, Charriot J, Roche N, Papaioannou AI, Kostikas K, Papadopoulos NG, Salvi S, Long D, Mitchell PD, Costello R, Sirena C, Cardini C, Heffler E, Puggioni F, Canonica GW, Guida G, Iwanaga T, Al-Ahmad M, García U, Kuna P, Fonseca JA, Al-Lehebi R, Koh MS, Rhee CK, Cosio BG, Perez de Llano L, Perng DS, Huang EW, Wang HC, Tsai MJ, Mahboub B, Salameh LIJ, Jackson DJ, Busby J, Heaney LG, Pfeffer PE, Goddard AG, Wang E, Hoyte FCL, Chapman NM, Katial R, Carter V, Bulathsinhala L, Eleangovan N, Ariti C, Lyu J, Porsbjerg C, Price DB., Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma., American journal of respiratory and critical care medicine, 209, (3), 2024, p262-272
Whetstone CE, Ranjbar M, Cusack RP, Al-Sajee D, Omer H, Alsaji N, Ho T, Duong M, Mitchell P, Satia I, Keith P, Xie Y, MacLean J, Sommer DD, Gauvreau GM, Protein expression of SARS-CoV-2 receptors ACE2 and TMPRSS2 in allergic airways after allergen challenge., Allergy, 2023
Pfeffer, P.E., Ali, N., Murray, R., Ulrik, C., Tran, T.N., Maspero, J., Peters, M., Christoff, G.C., Sadatsafavi, M., Torres-Duque, C.A., Altraja, A., Lehtimäki, L., Papadopoulos, N., Salvi, S., Costello, R.W., Cushen, B., Heffler, E., Iwanaga, T., Al-Ahmad, M., Larenas-Linnemann, D., Kuna, P., Fonseca, J.A., Al-Lehebi, R., Rhee, C.K., Perez-de-Llano, L., Perng Steve, D.-W., Mahboub, B., Wang, E., Goh, C., Lyu, J., Newell, A., Alacqua, M., Belevskiy, A.S., Bhutani, M., Bjermer, L., Bjornsdottir, U., Bourdin, A., Bulow, A.V., Busby, J., Canonica, G.W., Cosio, B.G., Dorscheid, D.R., Muñoz-Esquerre, M., FitzGerald, J.M., Gil, E.G., Gibson, P.G., Heaney, L.G., Hew, M., Hilberg, O., Hoyte, F., Jackson, D.J., Koh, M.S., Ko, H.-K.B., Lee, J.H., Lehmann, S., Chaves Loureiro, C., Lúðvíksdóttir, D., Menzies-Gow, A.N., Mitchell, P., Papaioannou, A.I., Popov, T.A., Porsbjerg, C.M., Salameh, L., Sirena, C., Taillé, C., Taube, C., Tohda, Y., Wechsler, M.E., Price, D.B., Comparative effectiveness of Anti-IL5 and Anti-IgE biologic classes in patients with severe asthma eligible for both, Allergy: European Journal of Allergy and Clinical Immunology, 2023
Shin JJ, Fan W, Par-Young J, Piecychna M, Leng L, Israni-Winger K, Qing H, Gu J, Zhao H, Schulz WL, Unlu S, Kuster J, Young G, Liu J, Ko AI, Baeza Garcia A, Sauler M, Wisnewski AV, Young L, Orduña A, Wang A, Klementina O, Garcia AB, Hegyi P, Armstrong ME, Mitchell P, Ordiz DB, Garami A, Kang I, Bucala R., MIF is a Common Genetic Determinant of COVID-19 Symptomatic Infection and Severity., QJM the Quarterly Journal of Medicine, 116, (3), 2023, p205 - 212
Menzies-Gow, A., Wechsler, M.E., Brightling, C.E., Korn, S., Corren, J., Israel, E., Chupp, G., Bednarczyk, A., Ponnarambil, S., Caveney, S., Almqvist, G., Go""bek, M., Simonsson, L., Lawson, K., Bowen, K., Colice, G., Hetzel, J.L., Fiterman, J., Souza Machado, A., Antila, M.A., Lima, M.A., Minamoto, S.E.T., Blanco, D.C., Bezerra, P.G.D.M., Houle, P.-A., Lemiere, C., Melenka, L.S., Leigh, R., Mitchell, P., Anees, S., Pek, B., Chouinard, G., Cheema, A.S., Yang, W.H.-C., Philteos, G., Chanez, P., Bourdin, A., Devouassoux, G., Taille, C., De Blay, F., Leroyer, C., Beurnier, A., Garcia, G., Girodet, P.-O., Blanc, F.-X., Magnan, A., Wanin, S., Just, J., Linde, R., Zielen, S., Förster, K., Geßner, C., Jandl, M., Buhl, R.O., Kornmann, M.O., Linnhoff, A., Ludwig-Sengpiel, A., Ehlers, M., Schmoller, T., Steffen, H., Hoffmann, M., Kirschner, J., Schmidt, O., Welte, T., Temme, H., Wand, O., Bar-Shai, A., Izbicki, G., Berkman, N., Fink, G., Shitrit, D., Adir, Y., Kuna, P., Rewerska, B., Pisarczyk-Bogacka, E., Kurbacheva, O., Mikhailov, S.L., Vasilev, M., Emelyanov, A., Wali, S., Albanna, A., van Zyl-Smit, R., Abdullah, I., Bernhardi, D., Hoosen, F., Irusen, E., Kalla, I., Lakha, D., Mitha, E., Naidoo, V., Nell, H., Padayachee, T., Reddy, J., Petrick, F., van der Walt, E., Vawda, Z.F.A., Park, H.-S., Lee, S.H., Kim, M.-K., Park, J.-W., Cho, Y.S., Lee, B.J., Chang, Y.-S., Park, C.-S., Lee, K.H., Lee, S.Y., Yoon, H., Sohn, K.H., Park, M.J., Min, K.H., Cho, Y.J., Park, H.K., Lee, Y., Lee, J., Sheu, C.-C., Tu, C.-Y., Lee, K.-Y., Bavbek, S., Gemicioglu, B., Ediger, D., Kalkan, I.K., Makieieva, N., Ostrovskyy, M., Dytyatkovs'ka, Y., Mostovoy, Y.M., Lebed, K., Yakovenko, O., Adams, A., Mooring, T., Torres Jr, L., Sexton, M., Thompson, E., Bernstein, J.A., Lisi, P., Chappel, C.M., Cole, J., Greenwald, G.I., Jones, C., Klein, R.M., Pham, D.N., Spangenthal, S., Weinstein, S.F., Windom, H.H., Kao, N.L., Leong, M.A., Mehta, V., Moore, W.C., Bhat, S., Aish, B., Meltzer, S.M., Moss, M.H., Kerwin, E.M., Delgado, J.P., Lucksinger, G.H., Thompson, C.A., Alpizar, S.A., Vadgama, S.V., Zafar, Z., Jacobs, J.S., Lugogo, N.J., Jain, N., Sher, L.D., Andrawis, N.S., Fuentes, D., Boren, E.J., Gonzalez, E.G., Talreja, N., Durrani, S.S., Sekhsaria, S., DeLeon, S., Shukla, M., Totszollosy Tarpay, M.M., Fakih, F., Hudes, G., Tillinghast, J.P., Korenblat, P.E., Shenoy, K., Que, L., Kureishy, S.A., Umeh, F.C., Nguyen, V.N., Chu, H.T., Nguyen, T.T.D., Long-term safety and efficacy of tezepelumab in people with severe, uncontrolled asthma (DESTINATION): a randomised, placebo-controlled extension study, The Lancet Respiratory Medicine, 11, (5), 2023, p425-438
Mitchell PD, Olaniyi J, Buckley C, Donnelly SC., Long COVID syndrome and the lung-How long will it last?, QJM : monthly journal of the Association of Physicians, 2022
Mitchell P.D., Buckley C., Subramaniam A., Crowther S., Donnelly S.C., Elevated serum ACE levels in patients with post-acute COVID-19 syndrome, QJM : monthly journal of the Association of Physicians, 115, (10), 2022, p651 - 652, p651-652
Ellis, A.K., Foran, V., Kaplan, A., Mitchell, P.D., Clarifying SABA overuse: Translating Canadian Thoracic Society guidelines into clinical practice, Allergy, Asthma and Clinical Immunology, 18, (1), 2022
Atwood, C.E., Bhutani, M., Ospina, M.B., Rowe, B.H., Leigh, R., Deuchar, L., Faris, P., Michas, M., Mrklas, K.J., Graham, J., Aceron, R., Damant, R., Green, L., Hirani, N., Longard, K., Meyer, V., Mitchell, P., Tsai, W., Walker, B., Stickland, M.K., Optimizing COPD Acute Care Patient Outcomes Using a Standardized Transition Bundle and Care Coordinator: A Randomized Clinical Trial, Chest, 162, (2), 2022, p321-330
Upham, J.W., Le Lievre, C., Jackson, D.J., Masoli, M., Wechsler, M.E., Price, D.B., Mansur, A., Detoraki, A., Altraja, A., James, A., Nanzer-Kelly, A., Côté, A., Menzies-Gow, A., Papaioannou, A., Cheffins, A.-M., Bourdin, A., Mahboub, B., Lipworth, B., Celis-Preciado, C.A., Torres-Duque, C., Bucca, C., Porsbjerg, C., Ulrik, C., Corrigan, C., Taube, C., Farah, C., Katelaris, C., Langton, D., Ryan, D., Larenas-Linnemann, D., Zervas, E., Heffler, E., Hoyte, F., Puggioni, F., Christoff, G., Canonica, G.W., Carpagnano, G.E., Guida, G., Katsoulotos, G., Brusselle, G., Rupani, H., Jersmann, H., Clifton, I., Dhariwal, J., Fingleton, J., Duke, J., Rimmer, J., Douglass, J., Fonseca, J., van Boven, J., Corless, J., Harrington, J., Maspero, J., Miguel, J.L., Pipatvech, K., Kenny, K., Chapman, K., Kostikas, K., Lehtimäki, L., Chung, L.P., Heaney, L., Hang, L.-W., Boulet, L.-P., Perez-de-Llano, L., Ricciardi, L., Idrees, M., Milanese, M., Conte, M.E., Costantino, M.T., Siyue, M.K., Fitzgerald, M., Hew, M., Peters, M., Tsai, M.-J., Patel, M., Khan, M.H., Sadatsafavi, M., Al-Ahmad, M., Yacoub, M.-R., De Gennaro, M., Radhakrishna, N., Hanania, N.A., Papadopoulos, N., Lugogo, N., Linaker, N., Crimi, N., Dennison, P., Nair, P., Mitchell, P.D., O'Byrne, P., Pfeffer, P., Kauppi, P., Hughes, P., Middleton, P., Wark, P., Bardin, P., Fu, P.-K., Akuthota, P., Chaudhuri, R., Campos, R., Al-Lehebi, R., Parente, R., Francisco, R., Wenzel, S., Pierachille, S., Pawar, S., Loukides, S., Fowler, S., Mackenzie, T., Brown, T., Lee Tan, T., Björnsdóttir, U., McDonald, V., Lawriwskyj, V., Backer, V., Vasileva, V., Chien, Y.-C., Harrington, Z., Defining a Severe Asthma Super-Responder: Findings from a Delphi Process, Journal of Allergy and Clinical Immunology: In Practice, 2021
Busby, J., Price, D., Al-Lehebi, R., Bosnic-Anticevich, S., van Boven, J.F.M., Emmanuel, B., Fitzgerald, J.M., Gaga, M., Hansen, S., Hew, M., Iwanaga, T., Linnemann, D.L., Mahboub, B., Mitchell, P., Morrone, D., Pham, J., Porsbjerg, C., Roche, N., Wang, E., Eleangovan, N., Heaney, L.G., Impact of socioeconomic status on adult patients with asthma: A population-based cohort study from uk primary care, Journal of Asthma and Allergy, 14, 2021, p1375-1388
Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., Canadian Thoracic Society 2021 Guideline update: Diagnosis and management of asthma in preschoolers, children and adults, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021
Lugogo, N., Liu, M.C., Pavord, I., Mitchell, P.D., Smith, S.G., Mallett, S., Albers, F.C., Bradford, E.S., Yancey, S.W., Bel, E.H., Clinical effects of mepolizumab in patients with severe eosinophilic asthma according to background therapy: A meta-analysis, Journal of Allergy and Clinical Immunology: In Practice, 9, (9), 2021, p3506-3509.e3
Yang, C.L., Hicks, E.A., Mitchell, P., Reisman, J., Podgers, D., Hayward, K.M., Waite, M., Ramsey, C.D., 2021 Canadian Thoracic Society Guideline"A focused update on the management of very mild and mild asthma, Canadian Journal of Respiratory, Critical Care, and Sleep Medicine, 2021
Kaplan, A., Mitchell, P.D., Cave, A.J., Gagnon, R., Foran, V., Ellis, A.K., Effective asthma management: Is it time to let the AIR out of SABA?, Journal of Clinical Medicine, 9, (4), 2020
Satia, I., Watson, R., Scime, T., Dockry, R.J., Sen, S., Ford, J.W., Mitchell, P.D., Fowler, S.J., Gauvreau, G.M., O'Byrne, P.M., Smith, J.A., Allergen challenge increases capsaicin-evoked cough responses in patients with allergic asthma, Journal of Allergy and Clinical Immunology, 144, (3), 2019, p788-795.e1
Mitchell, P., Leigh, R., A drug safety review of treating eosinophilic asthma with monoclonal antibodies, Expert Opinion on Drug Safety, 18, (12), 2019, p1161-1170
Leung, E., Mitchell, P.D., Emerging treatment options in severe asthma, Current Respiratory Medicine Reviews, 14, (2), 2018, p64-76
Mitchell, P.D., Salter, B.M., Oliveria, J.P., El-Gammal, A., Tworek, D., Smith, S.G., Sehmi, R., Gauvreau, G.M., O'Byrne, P.M., IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics, International Archives of Allergy and Immunology, 176, (2), 2018, p133-142
Lim, R., Marciniak, S.J., Marcadier, J., Rassl, D., Mitchell, P.D., Time is of the essence: A young man with recurrent pneumothorax and cavitating lung lesions, Annals of the American Thoracic Society, 15, (8), 2018, p988-989
, Biologics and the lung: TSLP and other epithelial cell-derived cytokines in asthma., Pharmacology & therapeutics, 2017
, Anti-IgE and Biologic Approaches for the Treatment of Asthma., Handbook of experimental pharmacology, 2017
, Glucagon-like peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation., Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2017
Tworek, D., Heroux, D., O'Byrne, S.N., Mitchell, P., O'Byrne, P.M., Denburg, J.A., Toll-like receptor-induced expression of epithelial cytokine receptors on haemopoietic progenitors is altered in allergic asthma, Clinical and Experimental Allergy, 47, (7), 2017, p900-908
, Epithelial-Derived Cytokines in Asthma., Chest, 2017
Anti-IgE and Biologic Approaches for the Treatment of AsthmaMitchell PD, El-Gammal A, O'Byrne PM.Handbook of Experimental Pharmacology.Pharmacology and therapeutics of asthma and COPD.Springer, United Kingdom., Pharmacology and Therapeutics of Asthma and COPD, 1, United Kingdom, Springer, 2017, 131 - 152pp
, IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma., Respiratory research, 2016
, Surfactant Protein-D and Asthma., Chest, 2016
Tang, W., Smith, S.G., Salter, B., Oliveria, J.P., Mitchell, P., Nusca, G.M., Howie, K., Gauvreau, G.M., O'Byrne, P.M., Sehmi, R., Allergen-induced increases in interleukin-25 and interleukin-25 receptor expression in mature Eosinophils from Atopic asthmatics, International Archives of Allergy and Immunology, 170, (4), 2016, p234-242
Canonica, G.W., Senna, G., Mitchell, P.D., O"Byrne, P.M., Passalacqua, G., Varricchi, G., Therapeutic interventions in severe asthma, World Allergy Organization Journal, 9, (1), 2016, p1-12
, Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma., American journal of respiratory and critical care medicine, 2016
, Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma., Clinical pharmacology and therapeutics, 2016
Mitchell PD, Das JP, Murphy DJ, Keane MP, Donnelly SC, Dodd JD, Butler MW, Idiopathic pulmonary fibrosis with emphysema: evidence of synergy among emphysema and idiopathic pulmonary fibrosis in smokers., 2015
Mitchell, P.D., King, T.J., O"Shea, D.B., Subcutaneous emphysema in acute asthma: A cause for concern?, Respiratory Care, 60, (8), 2015, pe141-e143
Mitchell, P.D., Kennedy, M.P., Bronchoscopic management of malignant airway obstruction, Advances in Therapy, 31, (5), 2014, p512-538
Chong, S.G., Mitchell, P., Fabre, A., McDonnell, T.J., Recurrent pneumothoraces in a 65-year-old female: An unusual case of cystic lung disease, European Respiratory Review, 23, (132), 2014, p271-272
Mitchell, P.D., Burke, L.M., Kennedy, M.P., Henry, M.T., A case of pulmonary amyloidosis, Thorax, 69, (6), 2014, p600
Harnett, C.M., Hunt, E.B., Bowen, B.R., O'Connell, O.J., Edgeworth, D.M., Mitchell, P., Eustace, J.A., Henry, M.T., Kennedy, M.P., Plant, B.J., Murphy, D.M., A study to assess inhaler technique and its potential impact on asthma control in patients attending an asthma clinic, Journal of Asthma, 51, (4), 2014, p440-445
O'Neill, A.C., McCarthy, C., Ridge, C.A., Mitchell, P., Hanrahan, E., Butler, M., Keane, M.P., Dodd, J.D., Rapid needle-out patient- rollover time after percutaneous CT-guided transthoracic biopsy of lung nodules: Effect on pneumothorax rate, Radiology, 262, (1), 2012, p314-319
Pallin, M., Walsh, S., O'Driscoll, M.F., Murray, C., Cahalane, A., Brown, L., Carter, M., Mitchell, P., McDonnell, T.J., Butler, M.W., Overwhelming support among urban Irish COPD patients for lung cancer screening by low-dose CT scan, Lung, 190, (6), 2012, p621-628
Slattery, E., Mitchell, P., Mulcahy, H.E., Cigarette smoking in Crohn's disease: Can we do more?, Journal of Crohn's and Colitis, 5, (5), 2011, p505
Kent BD, Mitchell PD, McNicholas WT., Hypoxemia in patients with COPD: cause, effects, and disease progression., International journal of chronic obstructive pulmonary disease, 6, 2011, p199-208
Non-Peer-Reviewed Publications
Gail Gauvreau, Roma Sehmi, J FitzGerald, Richard Leigh, Donald Cockcroft, Beth Davis, Irvin Mayers, Louis-Philippe Boulet, Brittany Salter, Ruth Cusack, Imran Satia, Kieran Killian, Patrick Mitchell, Viktoria Werkstrom, Tomasz Durzynski, Kathryn Shoemaker, Rohit Katial, Maria Jison, Paul Newbold, Paul O'Byrne, The effect of benralizumab on allergen-induced responses in subjects with mild allergic asthma, Journal of Allergy and Clinical Immunology, 147, (2), 2021, p157-
Research Expertise
Projects
- Title
- Implication of the upper respiratory tract microbiota in long-COVID patients and the role of the new emerging beneficial bacterium Dolosigranulum pigrum.
- Summary
- COVID-19 is a new disease with high mortality caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and responsible for the ongoing global pandemic. Different studies performed over the past year demonstrated a link between COVID-19 severity and the nasopharynx microbiota, however, studies investigating changes in microbiome components with regards to the aftermath of the disease, such as full recovery or development of long-term COVID-19 symptoms are still lacking. This project aims to fill this knowledge gap by performing an in-depth characterization of microbial communities associated with the upper respiratory tract of patients that developed long-term COVID-19 symptoms and those who presented full recovery using metagenomics and state-of-art statistical analysis. In addition, the protective role of the bacterium Dolosigranulum pigrum against COVID-19 will also be investigated through genomics and immunoassay procedures. This proposal will advance our knowledge and help the scientific community by shedding light on the composition of the nasopharynx microbiota and its role in patients' recovery. By investigating the genetic features of a new emerging beneficial bacterium of the upper respiratory tract, we aim at elucidating its role for the host and probiotic potential against severe and long-term SARS-CoV-2 outcome.
- Title
- Defining the impact of trained immunity in people with asthma: new target to reduce exacerbations and health costs associated with severe asthma
- Date From
- August 2024
- Date To
- August 2027
Recognition
Representations
Medical adviser GSK RSV Vaccine role out Ireland
Invited reviewer of the following journals: Thorax BMJ Open Chest European Respiratory Journal PLOS One Journal of Thoracic Disease Respiratory Research
Medical Advisor Asthma Society of Ireland
Canadian Thoracic Society Asthma Guideline Committee
Awards and Honours
The Asthma Society of Ireland and Irish Thoracic Society Joint Research Bursary
Austine Mehigan Award for Teaching Excellence St Vincents University Hospital
Memberships
Fellow of the Royal College of Physicians of Ireland
Member of the Association of Physicians of Great Britain and Ireland
Member of the Royal College of Physicians of Ireland
Member of the Irish Thoracic Society
Member of the European Respiratory Society