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Professor Kingston Mills
Professor, Biochemistry
Professor, Trinity Inst. of Neurosciences (TCIN)

Biography

Kingston Mills is Professor of Experimental Immunology, School of Biochemistry and Immunology, Trinity College Dublin (TCD). He is Head of The Centre for the Study of Immunology at Trinity Biomedical Sciences Institute and Theme Champion for Immunology, Inflammation and Infection at TCD. He is a graduate of TCD and trained at as a Postdoctoral Fellow at University College London and the National Institute for Medical Research, Mill Hill, London, before joining the Scientific Staff of NIBSC, Herts, UK. He returned to Ireland in 1993 to take up an academic position at National University of Ireland, Maynooth. He was appointed to a Personal Chair at Trinity College Dublin in 2001 and was Head of the School of Biochemistry and Immunology from 2008-2011. He heads an active research team focusing on T cells in infection, autoimmunity and cancer. He is co-founder of Opsona Therapeutics and TriMod Therapeutics, biotech companies focusing on the development of immunotherapeutics for inflammatory diseases and cancer.

Publications and Further Research Outputs

Peer-Reviewed Publications

Quinn S.M, Raverdeau M, McGinley A.M, Mills K.H.G, Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis, European Journal of Immunology, 2019 Journal Article, 2019 DOI URL

Raverdeau M, Christofi M, Malara A, Wilk M.M, Misiak A, Kuffova L, Yu T, McGinley A.M, Quinn S.M, Massilamany C, Reddy J, Forrester J.V, Mills K.H.G, Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity, EMBO Reports, 20, (5), 2019 Journal Article, 2019 DOI URL

Wilk M.M, Borkner L, Misiak A, Curham L, Allen A.C, Mills K.H.G, Immunization with whole cell but not acellular pertussis vaccines primes CD4 T RM cells that sustain protective immunity against nasal colonization with Bordetella pertussis, Emerging Microbes and Infections, 8, (1), 2019, p169 - 185 Journal Article, 2019 DOI URL TARA - Full Text

Brian Flood*, Joan Manils*, Ciara Nulty, Ewelina Flis, Sinead Kenealy, Gillian Barber, Joanna Fay, Kingston H. G. Mills, Elaine W. Kay and Emma M. Creagh. , Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis, Oncogene, 38, (14), 2019, p2658-2674 Journal Article, 2019 DOI TARA - Full Text

Zurita, M.E. and Wilk, M.M. and Carriquiriborde, F. and Bartel, E. and Moreno, G. and Misiak, A. and Mills, K.H.G. and Hozbor, D., A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection against Bordetella pertussis, including Pertactin Deficient Strains, Frontiers in Cellular and Infection Microbiology, 9, (APR), 2019 Journal Article, 2019 DOI

Quinn, S.M. and Cunningham, K. and Raverdeau, M. and Walsh, R.J. and Curham, L. and Malara, A. and Mills, K.H.G., Anti-inflammatory trained immunity mediated by helminth products attenuates the induction of T cell-mediated autoimmune disease, Frontiers in Immunology, 10, (MAY), 2019 Journal Article, 2019 DOI

Hughes, M.M. and Hooftman, A. and Angiari, S. and Tummala, P. and Zaslona, Z. and Runtsch, M.C. and McGettrick, A.F. and Sutton, C.E. and Diskin, C. and Rooke, M. and Takahashi, S. and Sundararaj, S. and Casarotto, M.G. and Dahlstrom, J.E. and Palsson-McDermott, E.M. and Corr, S.C. and Mills, K.H.G. and Preston, R.J.S. and Neamati, N. and Xie, Y. and Baell, J.B. and Board, P.G. and O'Neill, L.A.J., Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation, Cell Reports, 29, (1), 2019, p151-161.e5 Journal Article, 2019 TARA - Full Text DOI

Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and AndrÀ, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and BÃŒscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and Ä iÄ in-Å ain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De Biasi, S. and Del Zotto, G. and Dela Cruz, G.V. and Delacher, M. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di Santo, J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and Dörner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, A. and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and González-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and GrÃŒtzkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and HÀmmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hernández, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and Höfer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and Höllt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and JÀck, H.-M. and Jani, P.K. and Jávega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and KÃŒhne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGu, Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition), European Journal of Immunology, 49, (10), 2019, p1457-1973 Journal Article, 2019 DOI TARA - Full Text

Diavatopoulos, D.A. and Mills, K.H.G. and Kester, K.E. and Kampmann, B. and Silerova, M. and Heininger, U. and van Dongen, J.J.M. and van der Most, R.G. and Huijnen, M.A. and Siena, E. and Mielcarek, N. and Ochs, M.M. and Denoël, P. and Berbers, G. and Buisman, A.M. and de Jonge, M.I. and Fenwick, C. and Gorringe, A. and He, Q. and Kelly, D. and Le Grand, R. and Locht, C. and Mascart, F. and Mertsola, J. and Orfao, A. and Pantaleo, G. and Pollard, A.J. and Preston, A. and Read, R. and Sebo, P. and van Els, C. and Vecerek, B. and Londoño-Hayes, P. and de Groot, R., PERISCOPE: road towards effective control of pertussis, The Lancet Infectious Diseases, 19, (5), 2019, pe179-e186 Journal Article, 2019 DOI

McGinley, A.M. and Edwards, S.C. and Raverdeau, M. and Mills, K.H.G., Th17 cells, γΎ T cells and their interplay in EAE and multiple sclerosis, Journal of Autoimmunity, 87, 2018, p16-25 Journal Article, 2018 DOI

Fuchs, A. and Gliwinski, M. and Grageda, N. and Spiering, R. and Abbas, A.K. and Appel, S. and Bacchetta, R. and Battaglia, M. and Berglund, D. and Blazar, B. and Bluestone, J.A. and BornhÃ"user, M. and Brinke, A. and Brusko, T.M. and Cools, N. and Cuturi, M.C. and Geissler, E. and Giannoukakis, N. and Golab, K. and Hafler, D.A. and van Ham, S.M. and Hester, J. and Hippen, K. and Di Ianni, M. and Ilic, N. and Isaacs, J. and Issa, F. and Iwaszkiewicz-Grzes, D. and Jaeckel, E. and Joosten, I. and Klatzmann, D. and Koenen, H. and Kooten, C. and Korsgren, O. and Kretschmer, K. and Levings, M. and Marek-Trzonkowska, N.M. and Martinez-Llordella, M. and Miljkovic, D. and Mills, K.H.G. and Miranda, J.P. and Piccirillo, C.A. and Putnam, A.L. and Ritter, T. and Roncarolo, M.G. and Sakaguchi, S. and Sánchez-Ramón, S. and Sawitzki, B. and Sofronic-Milosavljevic, L. and Sykes, M. and Tang, Q. and Vives-Pi, M. and Waldmann, H. and Witkowski, P. and Wood, K.J. and Gregori, S. and Hilkens, C.M.U. and Lombardi, G. and Lord, P. and Martinez-Caceres, E.M. and Trzonkowski, P., Minimum information about T regulatory cells: A step toward reproducibility and standardization, Frontiers in Immunology, 8, (JAN), 2018, p01844- Journal Article, 2018 DOI TARA - Full Text

Borkner L, Misiak A, Wilk M.M, Mills K.H.G, Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory, Frontiers in immunology, 9, 2018, p1764- Journal Article, 2018 URL DOI

Michelet, X. and Dyck, L. and Hogan, A. and Loftus, R.M. and Duquette, D. and Wei, K. and Beyaz, S. and Tavakkoli, A. and Foley, C. and Donnelly, R. and O†Farrelly, C. and Raverdeau, M. and Vernon, A. and Pettee, W. and O†Shea, D. and Nikolajczyk, B.S. and Mills, K.H.G. and Brenner, M.B. and Finlay, D. and Lynch, L., Metabolic reprogramming of natural killer cells in obesity limits antitumor responses, Nature Immunology, 19, (12), 2018, p1330-1340 Journal Article, 2018 DOI

Allen, A.C. and Wilk, M.M. and Misiak, A. and Borkner, L. and Murphy, D. and Mills, K.H.G., Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells, Mucosal Immunology, 11, (6), 2018, p1763-1776 Journal Article, 2018 DOI

Solans, L. and Debrie, A.-S. and Borkner, L. and Aguiló, N. and Thiriard, A. and Coutte, L. and Uranga, S. and Trottein, F. and Martín, C. and Mills, K.H.G. and Locht, C., IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine, Mucosal Immunology, 11, (6), 2018, p1753-1762 Journal Article, 2018 DOI

Wilk, M.M. and Mills, K.H.G., CD4 TRM cells following infection and immunization: Implications for more effective vaccine design, Frontiers in Immunology, 9, (AUG), 2018, p01860- Journal Article, 2018 DOI TARA - Full Text

Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243 Journal Article, 2017 DOI

Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Akdis, M. and AndrÀ, I. and Annunziato, F. and Bacher, P. and Barnaba, V. and Battistini, L. and Bauer, W.M. and Baumgart, S. and Becher, B. and Beisker, W. and Berek, C. and Blanco, A. and Borsellino, G. and Boulais, P.E. and Brinkman, R.R. and BÌscher, M. and Busch, D.H. and Bushnell, T.P. and Cao, X. and Cavani, A. and Chattopadhyay, P.K. and Cheng, Q. and Chow, S. and Clerici, M. and Cooke, A. and Cosma, A. and Cosmi, L. and Cumano, A. and Dang, V.D. and Davies, D. and De Biasi, S. and Del Zotto, G. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Diefenbach, A. and Di Santo, J. and Dieli, F. and Dolf, A. and Donnenberg, V.S. and Dörner, T. and Ehrhardt, G.R.A. and Endl, E. and Engel, P. and Engelhardt, B. and Esser, C. and Everts, B. and Dreher, A. and Falk, C.S. and Fehniger, T.A. and Filby, A. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frenette, P.S. and Galbraith, D. and Garbi, N. and García-Godoy, M.D. and Geginat, J. and Ghoreschi, K. and Gibellini, L. and Goettlinger, C. and Goodyear, C.S. and Gori, A. and Grogan, J. and Gross, M. and GrÌtzkau, A. and Grummitt, D. and Hahn, J. and Hammer, Q. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Herrera, G. and Herrmann, M. and Hiepe, F. and Holland, T. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Hunter, C.A. and Iannone, A. and JÀck, H.-M. and Jávega, B. and Jonjic, S. and Juelke, K. and Jung, S. and Kaiser, T. and Kalina, T. and Keller, B. and Khan, S. and Kienhöfer, D. and Kroneis, T. and Kunkel, D. and Kurts, C. and Kvistborg, P. and Lannigan, J. and Lantz, O. and Larbi, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Levings, M.K. and Litwin, V. and Liu, Y. and Lohoff, M. and Lombardi, G. and Lopez, L. and Lovett-Racke, A. and Lubberts, E. and Ludewig, B. and Lugli, E. and Maecker, H.T. and Martrus, G. and Matarese, G. and Maueröder, C. and McGrath, M. and McInnes, I. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Mills, K. and Mirrer, D. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, A. and Moretta, L. and Mosmann, T.R. and MÌller, S. and MÌller, W. and MÌnz, C. and Multhoff, G. and Munoz, L.E. and Murphy, K.M. and Nakayama, T. and Nasi, M. and Neudörfl, C. and Nolan, J. and Nourshargh, S. and O'Connor, J.-E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Peterson, P. and Peth, C. and Petriz, J. and Philips, D. and Pickl, W. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Pucillo, C. and Quataert, S.A. and Radstake, T.R.D.J. and Rajwa, B. and Rebhahn, J.A. and Recktenwald, D. and Remmerswaal, E.B.M. and Rezvani, K. and Rico, L.G. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruckert, B. and Ruland, J. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sawitzki, B. and Scheffold, A. and Schiemann, M. and Schildberg, F. and Schimisky, E. and Schmid, S.A. and Schmitt, S. and Schober, K. and SchÌler, T. and Schulz, A.R. and Schumacher, T. and Scotta, C. and Shankey, T.V. and Shemer, A. and Simon, A.-K. and Spidlen, J. and Stall, A.M. and Stark, R. and Stehle, C. and Stein, M. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Tarnok, A. and Tian, Z. and Toldi, G. and Tornack, J. and Traggiai, E. and Trotter, J. and Ulrich, H. and van der Braber, M. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and, Guidelines for the use of flow cytometry and cell sorting in immunological studies, European Journal of Immunology, 47, (10), 2017, p1584-1797 Journal Article, 2017 DOI

Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP., In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis., Nucleic Acids Research, 45, (4), 2017, p2029-2039 Journal Article, 2017 DOI

Misiak A, Wilk M.M, Raverdeau M, Mills K.H.G, IL-17-producing innate and pathogen-specific tissue resident memory γΎ T cells expand in the lungs of Bordetella pertussis-infected mice, Journal of Immunology, 198, (1), 2017, p363 - 374 Journal Article, 2017 DOI URL

Netea, M.G. and Balkwill, F. and Chonchol, M. and Cominelli, F. and Donath, M.Y. and Giamarellos-Bourboulis, E.J. and Golenbock, D. and Gresnigt, M.S. and Heneka, M.T. and Hoffman, H.M. and Hotchkiss, R. and Joosten, L.A.B. and Kastner, D.L. and Korte, M. and Latz, E. and Libby, P. and Mandrup-Poulsen, T. and Mantovani, A. and Mills, K.H.G. and Nowak, K.L. and O'Neill, L.A. and Pickkers, P. and Van Der Poll, T. and Ridker, P.M. and Schalkwijk, J. and Schwartz, D.A. and Siegmund, B. and Steer, C.J. and Tilg, H. and Van Der Meer, J.W.M. and Van De Veerdonk, F.L. and Dinarello, C.A., A guiding map for inflammation, Nature Immunology, 18, (8), 2017, p826-831 Journal Article, 2017 DOI

Misiak, A. and Leuzzi, R. and Allen, A.C. and Galletti, B. and Baudner, B.C. and D'Oro, U. and O'Hagan, D.T. and Pizza, M. and Seubert, A. and Mills, K.H.G., Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model, Vaccine, 35, (39), 2017, p5256-5263 Journal Article, 2017 TARA - Full Text DOI

Gu, X.-X., Plotkin, S.A., Edwards, K.M., (...), Lu, K.T., Taylor, C.E. , Waning immunity and microbial vaccines-workshop of the National Institute of Allergy and infectious diseases, Clinical and Vaccine Immunology, 24, (7), 2017, pe00034-17 Journal Article, 2017 DOI

Nascimento, I.P., Rodriguez, D., Santos, C.C., (...), Rappuoli, R., Leite, L.C.C. , Recombinant BCG expressing LTAK63 adjuvant induces superior protection against Mycobacterium tuberculosis , Scientific Reports, 7, (1), 2017, p2109 Journal Article, 2017 DOI TARA - Full Text

Sutton, C.E. and Finlay, C.M. and Raverdeau, M. and Early, J.O. and DeCourcey, J. and Zaslona, Z. and O'Neill, L.A.J. and Mills, K.H.G. and Curtis, A.M., Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease, Nature Communications, 8, (1), 2017, p1923- Journal Article, 2017 DOI TARA - Full Text

McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12 Journal Article, 2017 DOI

Finlay, C.M. and Stefanska, A.M. and Coleman, M.M. and Jahns, H. and Cassidy, J.P. and McLoughlin, R.M. and Mills, K.H.G., Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy, Parasite Immunology, 39, (10), 2017, pe12460 - Journal Article, 2017 DOI

Dyck, L., Mills, K.H.G. , Immune checkpoints and their inhibition in cancer and infectious diseases, European Journal of Immunology, 47, (5), 2017, p765-779 Journal Article, 2017 DOI

Palsson-McDermott, E.M. and Dyck, L. and Zaslona, Z. and Menon, D. and McGettrick, A.F. and Mills, K.H.G. and O'Neill, L.A., Pyruvate kinase M2 is required for the expression of the immune checkpoint PD-L1 in immune cells and tumors, Frontiers in Immunology, 8, (OCT), 2017 Journal Article, 2017 DOI

Gardiner C.M, Mills K.H.G, The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases, Seminars in Immunology, 28, (4), 2016, p343-350 Journal Article, 2016 URL DOI

Mulcahy M.E, Leech J.M, Renauld J.-C, Mills K.H.G, McLoughlin R.M, Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa, Mucosal Immunology, 9, (6), 2016, p1429 - 1441 Journal Article, 2016 TARA - Full Text URL DOI

Raverdeau M, Breen C.J, Misiak A, Mills K.H.G, Retinoic acid suppresses IL-17 production and pathogenic activity of γΎ T cells in CNS autoimmunity, Immunology and Cell Biology, 94, (8), 2016, p763 - 773 Journal Article, 2016 DOI URL

Netea M.G, Joosten L.A.B, Latz E, Mills K.H.G, Natoli G, Stunnenberg H.G, O'Neill L.A.J, Xavier R.J, Trained immunity: A program of innate immune memory in health and disease, Science, 352, (6284), 2016, p427- Journal Article, 2016 DOI URL

Exley M.A, Tsokos G.C, Mills K.H.G, Elewaut D, Mulhearn B, What rheumatologists need to know about innate lymphocytes, Nature Reviews Rheumatology, 12, (11), 2016, 2016 Nov;12(11):658-668. doi: Journal Article, 2016 DOI URL

Lee J.P.W, Foote A, Fan H, Peral de Castro C, Lang T, Jones S.A, Gavrilescu N, Mills K.H.G, Leech M, Morand E.F, Harris J, Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages, Autophagy, 12, (6), 2016, p907 - 916 Journal Article, 2016 URL DOI

Dyck L, Wilk M.M, Raverdeau M, Misiak A, Boon L, Mills K.H.G, Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model, Cancer Immunol Immunother , 65, 2016, p1491- Journal Article, 2016 URL DOI

Saadatian-Elahi M, Plotkin S, Mills K.H.G, Halperin S.A, McIntyre P.B, Picot V, Louis J, Johnson D.R, Pertussis: Biology, epidemiology and prevention, Vaccine, 34, (48), 2016, p5819 - 5826 Journal Article, 2016 DOI URL

Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH., Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia., Journal of Immunology, 196, (2), 2016, p703-714 Journal Article, 2016 DOI

Coll, R.C. Robertson, A.A.B. Chae, J.J. Higgins, S.C. Muñoz-Planillo, R. Inserra, M.C. Vetter, I. Dungan, L.S. Monks, B.G. Stutz, A. Croker, D.E. Butler, M.S. Haneklaus, M. Sutton, C.E. Núñez, G. Latz, E. Kastner, D.L. Mills, K.H.G. Masters, S.L. Schroder, K. Cooper, M.A. O'Neill, L.A.J., A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases, Nature Medicine, 21, (3), 2015, p248 - 257 Journal Article, 2015 DOI URL

Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM, Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity., Journal of immunology (Baltimore, Md. : 1950), 195, (2), 2015, p528-40 Journal Article, 2015 DOI

Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH, A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine., Mucosal immunology, 8, (3), 2015, p607-617 Journal Article, 2015 DOI

Oficjalska K1, Raverdeau M1, Aviello G2, Wade SC1, Hickey A1, Sheehan KM3, Corr SC1, Kay EW3, O'Neill LA1, Mills KH1, Creagh EM4., Protective Role for Caspase-11 during Acute Experimental Murine Colitis., Journal of Immunology, 194, (3), 2015, p1252-1260 Journal Article, 2015 DOI TARA - Full Text

Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH, A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis., Mucosal immunology, 8, (5), 2015, p982 - 992 Journal Article, 2015 DOI

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 TARA - Full Text DOI

Netea M.G, Latz E, Mills K.H, O'Neill L.A, Innate immune memory: a paradigm shift in understanding host defense, Nature immunology, 16, (7), 2015, p675 - 679 Journal Article, 2015 URL DOI

Edwards S.C, McGinley A.M, McGuinness N.C, Mills K.H.G, γÎ" T cells and NK cells - distinct pathogenic roles as innate-like immune cells in CNS autoimmunity, Frontiers in Immunology, 6, (SEP), 2015, p1- Journal Article, 2015 URL DOI

McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560 Journal Article, 2015 DOI URL

Murphy A.G, O'Keeffe K.M, Lalor S.J, Maher B.M, Mills K.H.G, McLoughlin R.M, Staphylococcus aureus infection of mice expands a population of memory γΎ T cells that are protective against subsequent infection (Journal of Immunology (2014) 192 (3697-3708)), Journal of Immunology, 194, (9), 2015, p4588- Journal Article, 2015 DOI URL

Flood, B., Oficjalska, K., Laukens, D., Fay, J., Mills, K.H., Sheahan, K., Ryan, E.J., Doherty, G.A., Kay, E.W. and Creagh, E.M. , Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential. , Clinical and Experimental Immunology, 181, (1), 2015, p39-50 Journal Article, 2015 TARA - Full Text DOI

Brummelman J, Wilk MM, Han WG, van Els CA, Mills KH, Roads to the development of improved pertussis vaccines paved by immunology., Pathogens and disease, 73, (8), 2015, pftv067 Journal Article, 2015 DOI TARA - Full Text

Edwards SC, McGinley AM, McGuinness NC, Mills KH, γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity., Frontiers in immunology, 6, 2015, p455 Journal Article, 2015 TARA - Full Text DOI

Edwards S.C, Higgins S.C, Mills K.H.G, Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction, Brain, Behavior, and Immunity, 50, 2015, p41 - 46 Journal Article, 2015 TARA - Full Text DOI URL

Mills KH, Ross PJ, Allen AC, Wilk MM, Do we need a new vaccine to control the re-emergence of pertussis?, Trends in microbiology, 22, (2), 2014, p49-52 Journal Article, 2014 DOI

Mills KH, Prior Exposure to Bacteria Attenuates Viral Disease of the Respiratory Tract: A Role for IL-17 and Innate Immune Memory?, American journal of respiratory and critical care medicine, 189, (2), 2014, p126-8 Journal Article, 2014 DOI TARA - Full Text

Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17 Journal Article, 2014 URL DOI TARA - Full Text

McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121 Journal Article, 2014 DOI TARA - Full Text

Raverdeau M, Mills KH, Modulation of T cell and innate immune responses by retinoic Acid., Journal of immunology (Baltimore, Md. : 1950), 192, (7), 2014, p2953-8 Journal Article, 2014 TARA - Full Text DOI

Mills KH, Gerdts V, Mouse and Pig Models for Studies of Natural and Vaccine-Induced Immunity to Bordetella pertussis., The Journal of infectious diseases, 209 Suppl 1, 2014, pS16-9 Journal Article, 2014 DOI TARA - Full Text

Adkins I, Kamanova J, Kocourkova A, Svedova M, Tomala J, Janova H, Masin J, Chladkova B, Bumba L, Kovar M, Ross PJ, Tuckova L, Spisek R, Mills KH, Sebo P, Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells., PloS one, 9, (8), 2014, pe104064 Journal Article, 2014 DOI TARA - Full Text

Murphy, AG, O'Keeffe, KM, Lalor, SJ, Maher, BM, Mills, KHG, McLoughlin, RM, Staphylococcus aureus Infection of Mice Expands a Population of Memory gamma delta T Cells That Are Protective against Subsequent Infection, JOURNAL OF IMMUNOLOGY, 192, (8), 2014, p3697-3708 Journal Article, 2014 DOI TARA - Full Text

Allen AC, Mills KH, Improved pertussis vaccines based on adjuvants that induce cell-mediated immunity., Expert review of vaccines, 13, (10), 2014, p1253-1264 Journal Article, 2014 DOI

Finlay CM, Walsh KP, Mills KH, Induction of regulatory cells by helminth parasites: exploitation for the treatment of inflammatory diseases., Immunological reviews, 259, (1), 2014, p206-30 Journal Article, 2014 DOI

Draper, Eve DeCourcey, Joseph Higgins, Sarah C. Canavan, Mary McEvoy, Fiona Lynch, Mark Keogh, Brian Reynolds, Clare Roche, Helen M. Mills, Kingston H. G. Loscher, Christine E., Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses, The Journal of Nutritional Biochemistry, 25, (7), 2014, p741-9 Journal Article, 2014 TARA - Full Text

Morine, M.J., Toomey, S., McGillicuddy, F.C., Reynolds, C.M., Power, K.A., Browne, J.A., Loscher, C., (...), Roche, H.M., Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice, Journal of Nutritional Biochemistry, 24, (5), 2013, p788-795 Journal Article, 2013 TARA - Full Text DOI

Mills, K.H.G., Dungan, L.S., Jones, S.A., Harris, J., The role of inflammasome-derived IL-1 in driving IL-17 responses, Journal of Leukocyte Biology, 93, (4), 2013, p489-497 Journal Article, 2013 TARA - Full Text DOI

Walsh, K.P., Mills, K.H.G., Dendritic cells and other innate determinants of T helper cell polarisation, Trends in Immunology, 34, (11), 2013, p521-530 Journal Article, 2013 DOI

Ross PJ, Sutton CE, Higgins S, Allen AC, Walsh K, Misiak A, Lavelle EC, McLoughlin RM, Mills KH, Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine., PLoS pathogens, 9, (4), 2013, pe1003264 Journal Article, 2013 TARA - Full Text DOI

Butt AQ, Mills KH, Immunosuppressive networks and checkpoints controlling antitumor immunity and their blockade in the development of cancer immunotherapeutics and vaccines., Oncogene, 2013 Journal Article, 2013 DOI TARA - Full Text

Jones SA, Mills KH, Harris J., Autophagy and inflammatory diseases., Immunology and Cell Biology, 91, (3), 2013, p250-258 Journal Article, 2013 TARA - Full Text DOI

Galvin, K.C., Dyck, L., Marshall, N.A., Stefanska, A.M., Walsh, K.P., Moran, B., Higgins, S.C., (...), Mills, K.H.G., Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells, Cancer Immunology, Immunotherapy, 62, (7), 2013, 1273-1282 Journal Article, 2013 DOI TARA - Full Text

Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51 Journal Article, 2013 TARA - Full Text DOI

McGillicuddy FC, Reynolds CM, Finucane O, Coleman E, Harford KA, Grant C, Sergi D, Williams LM, Mills KH, Roche HM, Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I deficient mice., American journal of physiology. Endocrinology and metabolism, 305, (2), 2013, pE834-E844 Journal Article, 2013 DOI TARA - Full Text

Coleman MM, Ruane D, Moran B, Dunne PJ, Keane J, Mills KH, Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells., American journal of respiratory cell and molecular biology, 48, (6), 2013, p773-80 Journal Article, 2013 DOI TARA - Full Text

Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, Misiak A, Dungan LS, Sutton CE, Streubel G, Bracken AP, Mills KH, Retinoic acid expression associates with enhanced IL-22 production by "" T cells and innate lymphoid cells and attenuation of intestinal inflammation., The Journal of experimental medicine, 210, (6), 2013, p1117-24 Journal Article, 2013 TARA - Full Text DOI

Coleman MM, Finlay CM, Moran B, Keane J, Dunne PJ, Mills KH, The Immunoregulatory role of CD4(+) FoxP3(+) CD25(-) regulatory T cells in lungs of mice infected with Bordetella pertussis., FEMS Immunology and Medical Microbiology, 64, (3), 2012, p413 - 424 Journal Article, 2012 DOI

Higgs R, Higgins SC, Ross PJ, Mills KH, Immunity to the respiratory pathogen Bordetella pertussis., Mucosal immunology, 5, (5), 2012, p485-500 Journal Article, 2012 DOI

Reynolds CM, McGillicuddy FC, Harford KA, Finucane OM, Mills KH, Roche HM, Dietary saturated fatty acids prime the NLRP3 inflammasome via TLR4 in dendritic cells-implications for diet-induced insulin resistance., Molecular nutrition & food research, 56, (8), 2012, p1212-1222 Journal Article, 2012 DOI

Marshall NA, Galvin KC, Corcoran AM, Boon L, Higgs R, Mills KH, Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-ã+IL-17+ polyfunctional T-cells that mediate rejection of murine tumors, Cancer Research, 72, (3), 2012, p581-591 Journal Article, 2012 DOI URL

Sutton CE, Mielke LA, Mills KH, IL-17-producing gamma delta T cells and innate lymphoid cells., European Journal of Immunology, 42, (9), 2012, p2221-2231 Journal Article, 2012 DOI

Peral de Castro C, Jones SA, Ní Cheallaigh C, Hearnden CA, Williams L, Winter J, Lavelle EC, Mills KH, Harris J, Autophagy Regulates IL-23 Secretion and Innate T Cell Responses through Effects on IL-1 Secretion., Journal of immunology (Baltimore, Md. : 1950), 189, (8), 2012, p4144-4153 Journal Article, 2012 DOI

Conroy H, Galvin KC, Higgins SC, Mills KH, Gene silencing of TGF-ß1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells., Cancer Immunology & Immunotherapy, 61, (3), 2012, p425-431 Journal Article, 2012 DOI

Morine MJ, Toomey S, McGillicuddy FC, Reynolds CM, Power KA, Browne JA, Loscher C, Mills KH, Roche HM, Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice., The Journal of nutritional biochemistry, 2012, p228-236 Journal Article, 2012 DOI

Allen AC, Kelly S, Basdeo SA, Kinsella K, Mulready KJ, Mills KH, Tubridy N, Walsh C, Brady JJ, Hutchinson M, Fletcher JM, A pilot study of the immunological effects of high-dose vitamin D in healthy volunteers., Multiple sclerosis (Houndmills, Basingstoke, England), 18, (12), 2012, p1797 - 1800 Journal Article, 2012 DOI

Cunningham CC, Mills E, Mielke LA, O'Farrell LK, Lavelle E, Mori A, McCarthy GM, Mills KH, Dunne A, Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase., Clinical immunology (Orlando, Fla.), 144, (3), 2012, p228-236 Journal Article, 2012 DOI

Immunology of Multiple Sclerosis in, The Biology of Multiple Sclerosis, Cambridge University Press, 2012, pp1-146 , [Fletcher JM and Mills KHG] Book Chapter, 2012 URL

Jones, S.A., Sutton, C.E., Cua, D., Mills, K.H.G., Therapeutic potential of targeting IL-17 , Nature Immunology, 13, (11), 2012, p1022-1025 Journal Article, 2012 DOI

Pindjakova J, Hanley SA, Duffy MM, Sutton CE, Weidhofer GA, Miller MN, Nath KA, Mills KH, Ceredig R, Griffin MD, Interleukin-1 accounts for intrarenal Th17 cell activation during ureteral obstruction., Kidney International, 81, (4), 2012, p379-390 Journal Article, 2012 TARA - Full Text DOI

Cheryl M. Sweeney, Roisin Lonergan, Sharee A. Basdeo, Katie Kinsella, Lara S. Dungan, Sarah C. Higgins, Patrick J. Kelly, Lisa Costelloe, Niall Tubridy, Kingston H.G. Mills, Jean M. Fletcher, IL-27 mediates the response to IFN beta therapy in multiple sclerosis patients by inhibiting Th17 cells, Brain, Behavior and Immunity, 25, (6), 2011, p1170-1181 Journal Article, 2011 TARA - Full Text

Mills KH, TLR-dependent T cell activation in autoimmunity., Nature Reviews Immunology, 11, (12), 2011, p807-22 Journal Article, 2011 DOI TARA - Full Text

Marina A. Lynch and Kingston H.G. Mills, Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases, Brain, Behavior, and Immunity, 26, (1), 2011, p1-10 Journal Article, 2011 TARA - Full Text

Lalor, S.J., Dungan, L.S., Sutton, C.E., Basdeo, S.A., Fletcher, J.M., Mills, K.H.G., Caspase-1-processed cytokines IL-1β and IL-18 promote IL-17 production by γδ and CD4 T cells that mediate autoimmunity, Journal of Immunology, 186, (10), 2011, p5738-5748 Journal Article, 2011 DOI

Byrne WL, Mills KH, Lederer JA, O'Sullivan GC, Targeting regulatory T cells in cancer., Cancer research, 71, (22), 2011, p6915-6920 Journal Article, 2011 DOI

Sisti F, Fernández J, Higgins SC, Casabuono A, Couto A, Mills KH, Hozbor D, A deep rough type structure in Bordetella bronchiseptica lipopolysaccharide modulates host immune responses., Microbiology and immunology, 55, (12), 2011, p847-854 Journal Article, 2011 DOI

McLoughlin, R.M., Mills, K.H.G., Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma, Journal of Allergy and Clinical Immunology, 127, (5), 2011, p1097-1107 Journal Article, 2011 DOI

Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100-111 Journal Article, 2011 TARA - Full Text DOI

McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH, Roche HM, Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis., Diabetes, 60, (6), 2011, p1688-98 Journal Article, 2011 DOI

Brereton, C.F., Sutton, C.E., Ross, P.J., Iwakura, Y., Pizza, M., Rappuoli, R., Lavelle, E.C., Mills, K.H.G., Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production, Journal of Immunology, 186, (10), 2011, p5896-5906 Journal Article, 2011 DOI

Dungan, L.S., and Mills, K.H.G , Caspase-1-processed IL-1 family cytokines play a vital role in driving innate IL-17. , Cytokine, 56, (1), 2011, p126 - 132 Journal Article, 2011 DOI

Dunne A, Marshall NA, Mills KH, TLR based therapeutics., Current opinion in pharmacology, 11, (4), 2011, p404-11 Review, 2011 DOI

Eve Draper, Clare M. Reynolds, Mary Canavan, Kingston H. Mills, Christine E. Loscher, and Helen M. Roche, Omega-3 fatty acids attenuate dendritic cell function via NF-kappa B independent of PPAR gamma, Journal of Nutritional Biochemistry, 22, (8), 2011, p784-790 Journal Article, 2011 TARA - Full Text

Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607 Journal Article, 2010 TARA - Full Text

O'Brien M, Lonergan R, Costelloe L, O'Rourke K, Fletcher JM, Kinsella K, Sweeney C, Antonelli G, Mills KH, O'Farrelly C, Hutchinson M, Tubridy N. , OAS1: a multiple sclerosis susceptibility gene that influences disease severity., Neurology, 75, (5), 2010, p411 - 418 Journal Article, 2010 DOI

Masters, S.L., Dunne, A., Subramanian, S.L., Hull, R.L., Tannahill, G.M., Sharp, F.A., Becker, C., Lavelle,E.C. and O'Neill, L.A.J., Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β 2 in type 2 diabetes , Nature Immunology, 11, (10), 2010, p897-904 Journal Article, 2010 DOI

Coleman MM, Keane J, Mills KH., Tregs and BCG--dangerous liaisons in TB., Journal of Leukocyte Biology, 88, (6), 2010, p1067 - 1069 Journal Article, 2010 DOI

McGuirk, P., Higgins, S.C., Mills, K.H.G, The role of regulatory T cells in respiratory infections and allergy and asthma, Current Allergy and Asthma Reports, 10, (1), 2010, p21-28 Journal Article, 2010 TARA - Full Text

Dunne A, Ross PJ, Pospisilova E, Masin J, Meaney A, Sutton CE, Iwakura Y, Tschopp J, Sebo P, Mills KH, Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis., Journal of Immunology , 185, (3), 2010, p1711-9 Journal Article, 2010 TARA - Full Text URL DOI

Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC, Mills KH., Response: Characteristics of IL-17-Producing gammadelta T Cells., Immunity, 32, (1), 2010, p3 - 4 Journal Article, 2010 DOI

Fletcher, J.M., Lalor, S.J., Sweeney, C.M., Tubridy, N., Mills, K.H.G, T cells in multiple sclerosis and experimental autoimmune encephalomyelitis , Clinical and Experimental Immunology, 162, (1), 2010, p1-11 Review Article, 2010 TARA - Full Text

Masters, S.L., Mielke, L.A. Cornish, A.L., Sutton, C.E., Cengia, L., Roberts, A.W., Wicks, I.P. Mills, K.H.G. and Croker, B.A. , Regulation of interleukin-1β by interferon-γ is species specific, limited by suppressor of cytokine signalling 1 and influences interleukin-17 production , EMBO Reports, 11, (8), 2010, p640 - 646 Journal Article, 2010 DOI

Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607 Journal Article, 2010 TARA - Full Text

Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128 Journal Article, 2010 URL DOI

Higgins, S.C., Mills, K.H.G, TLR, NLR agonists, and other immune modulators as infectious disease vaccine adjuvants, Current Infectious Disease Reports, 12, (1), 2010, p4-12 Journal Article, 2010 TARA - Full Text

Mills, K.H.G., Jarnicki, AJ, Toomey D, TCD, Compositions and methods for the treatment of cancer and infectious diseases, 2009, 12/085787 Patent, 2009

Walsh, KP, Brady, MT, Finlay, CM, Boon, L, Mills, KH, Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses., Journal of Immunology , 183, (3), 2009, p1577 - 1586 Journal Article, 2009 TARA - Full Text DOI

Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM, A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4., The Journal of Nutrition, 139, (12), 2009, p2351-2357 Journal Article, 2009 DOI

Sutton, C.E., Lalor, S.J., Sweeney, C.M., Brereton, C.F., Lavelle, E.C. and Mills, K.H.G , Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity., Immunity, 31, (2), 2009, p331-341 Journal Article, 2009 DOI TARA - Full Text

de Roos, B, Rungapamestry, V, Ross, K, Rucklidge, G, Reid, M, Duncan, G, Horgan, G, Toomey, S, Browne, J, Loscher, CE, Mills, KH, Roche, HM, Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet., Proteomics, 9, (12), 2009, p3244 - 3256 Journal Article, 2009 DOI

Dunne PJ, Moran B, Cummins RC and Mills KH , CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. , The Journal of Immunology, 183, 2009, p400 - 410 Journal Article, 2009 DOI TARA - Full Text

Mills KH, Dunne A, Immune modulation: IL-1, master mediator or initiator of inflammation, Nature Medicine, 15, (12), 2009, p1363-1364 Review, 2009 DOI TARA - Full Text

Mills, KH, Designer adjuvants for enhancing the efficacy of infectious disease and cancer vaccines based on suppression of regulatory T cell induction., Immunology letters, 122, (2), 2009, p108-111 Journal Article, 2009 DOI

N.M. Curtin, K.H.G. Mills and T.J. Connor, Psychological stress increases expression of IL-10 and its homolog IL-19 via beta-adrenoceptor activation: Reversal by the anxiolytic chlordiazepoxide, Brain Behavior and Immunity, 23, (3), 2009, p371 - 379 Journal Article, 2009 DOI

N.M. Curtin, N.T. Boyle, K.H.G. Mills and T.J. Connor, Psychological stress suppresses innate IFN-gamma production via glucocorticoid receptor activation: Reversal by the anxiolytic chlordiazepoxide., Brain Behavior and Immunity, 23, 2009, p535 - 547 Journal Article, 2009 TARA - Full Text DOI

Mills, K.H.G. and Higgins, S., TCD, Compounds and methods for the treatment of autoimmune and inflammatory disorders, 2009, PCT/EP2009/067819 Patent, 2009

Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027 Journal Article, 2009 DOI

Brereton CF, Sutton CE, Lalor SJ, Lavelle EC, Mills KH., Inhibition of ERK MAPK suppresses IL-23- and IL-1-driven IL-17 production and attenuates autoimmune disease., Journal of Immunology, 183, (3), 2009, p1715-2173 Journal Article, 2009 TARA - Full Text DOI

Fletcher JM, Lonergan R, Costelloe L, Kinsella K, Moran B, O'Farrelly C, Tubridy N, Mills KH, CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis., Journal of Immunology , 183, (11), 2009, p7602-7610 Journal Article, 2009 DOI TARA - Full Text

Jarnicki, AJ, Conroy, H. Brereton, C, Donnelly, G., Toomey, D., Walsh, K.,, Sweeney, C., Leavy, O., Fletcher, J., Lavelle, E., Dunne, P. and Mills, K.H.G., Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics, Journal of Immunology, 180, (6), 2008, p3797 - 3806 Journal Article, 2008 TARA - Full Text URL

Toomey, D., Conroy, H., Jarnicki, A.G., Higgins, S.C., Sutton, C., Mills, K.H.G. , Therapeutic vaccination with dendritic cells pulsed with tumor-derived Hsp70 and a COX-2 inhibitor induces protective immunity against B16 melanoma , Vaccine, 26, (27-28), 2008, p3540-3549 Journal Article, 2008 DOI URL

Hickey, F.B., Brereton, C.F., Mills, K.H.G. , Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells , Journal of Leukocyte Biology , 84, (1), 2008, p234-243 Journal Article, 2008 DOI TARA - Full Text

Mills, K.H.G. , TLR9 Turns the Tide on Treg Cells , Immunity, 28, (4), 2008, 518-520 Journal Article, 2008 DOI TARA - Full Text URL

Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969 Journal Article, 2008 URL DOI

Conroy, H. Marshall, N.A. and Mills, K.H.G., TLR ligand suppression or enhancement of Treg cell - A double edged sword in immunity to tumors. , Oncogene, 27, (2), 2008, p168 - 180 Journal Article, 2008 URL DOI

Mills, KH, Induction, function and regulation of IL-17-producing T cells., European Journal of Immunology, 38, (10), 2008, p2636-2649 Journal Article, 2008 DOI

Rowan AG, Fletcher JM, Ryan EJ, Moran B, Hegarty JE, O'Farrelly C and Mills KHG, Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta, Journal of Immunology, 181, (7), 2008, p4485 - 4494 Journal Article, 2008 URL TARA - Full Text

IL-10 and TGF-beta-producing regulatory T cells in infection in, editor(s)Shuiping Jiang , Regulatory cells and Clinical Application, Springer Science and Business Media, LLC , 2008, pp423 - 453, [Dunne PJ, Rowan A, Fletcher JM and KHG Mills] Book Chapter, 2008

Fennelly, N.F., Sisti, F, Higgins, S.C., Ross, P., van der Heide, H. Mooi, F.R., Boyd, A.P. and Mills, K.H.G., Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses., Infection and Immunity, 76, (3), 2008, p1257 - 1266 Journal Article, 2008 TARA - Full Text DOI

Braat, H, McQuirk, P., Ten Kate F.J.W., Huibregtse, I., Dunne, P, Hommes, D.W., Deventer, S and Mills, K. H.G. , Prevention of experimental colitis by parenteral administration of a pathogen derived immunomodulatory molecule. , Gut, 56, 2007, p351 - 357 Journal Article, 2007 DOI URL

Lysaght, J., Jarnicki, A. and Mills, K.H.G. , Reciprocal effects of Th1 and Treg cell inducing pathogen-associated immunomodulatory molecules on anti-tumour immunity. , Cancer Immunology and Immunotherapy, Published online Feb, (DOI 10.1007/s00262-0), 2007, p1367 - 1379 Journal Article, 2007 URL DOI

Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313 Journal Article, 2007 DOI TARA - Full Text

Jarnicki, A.G., Lysaght, J, Todryk, S, Mills, K.H.G, Suppression of antitumor immunity by IL-10 and TGF-b-producing T cells infiltrating the growing tumor: influence of tumor environment on the induction of CD4+ and CD8+ regulatory T cells., Journal of Immunology, 177, (2), 2006, p896-904 Journal Article, 2006 URL TARA - Full Text

Stephenson, I., Nicholson, K.G. Rudin, A. Colegate, A., Podda, A. Bugarini, R., del Giudice, G., Minutello, A., Bonnington, S., Holmgren, J., Mills, K.H.G, and Zambon, M.C., Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers, The Journal of Virology, 80, (10), 2006, p4962 - 4970 Journal Article, 2006 DOI TARA - Full Text URL

Sutton, C., Brereton, C., Keogh, B., Mills, K.H.G. Lavelle, E.C., A crucial role for IL-1 in the induction of IL-17 producing T cells that mediate autoimmune encephalomyelitis, The Journal of Experimental Medicine, 203, (7), 2006, p1685 - 1691 Journal Article, 2006

Lipinski, K.S., Pelech, S., Mountain, A., Irvine, A.S., Kraaij, R., Bangma, C.H., Mills, K.H.G. and Todryk S.M, Nitroreductase-based therapy of prostate cancer, enhanced by raising expression of heat shock protein 70, acts through increased anti-tumour immunity. , Cancer Immunology and Immunotherapy, 55, (3), 2006, p347 - 354 Journal Article, 2006 DOI URL

Higgins, S., Jarnicki, A, Lavelle, E.C. and Mills, K.H.G, TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells, The Journal of Immunology, 177, 2006, p7980 - 7989 Journal Article, 2006 TARA - Full Text URL

Modified Bacterial toxins in, editor(s)D. Harn and C.J Hackett , Vaccine Adjuvants: Immunological and Clinical Principles, Humana Press, 2005, pp113 - 155, [Lavelle, E., Leavy, O., Mills, K.H.G.] Book Chapter, 2005

Daly, L.M., Johnson, P.A., Nicolson, C., Robertson, J. and Mills, K.H.G., Innate IL-10 promotes the induction of Th2 responses with plasmid DNA expressing HIV gp120, Vaccine, 23, 2005, p963 - 974 Journal Article, 2005 DOI URL

Djeha HA, Todryk SM, Pelech S, Wrighton CJ, Irvine AS, Mountain A, Mills, K.H.G., Lipinski KS , Anti-tumour immune response mediated by Adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level co-expression of heat shock protein 70., Cancer Gene Therapy, 12, (6), 2005, p560-571 Journal Article, 2005 DOI URL

Boyd, A.P., Ross, P.J., Conroy, H., Mahon, N Lavelle, E.C.and Mills, K.H.G., Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death, Journal of Immunology, 175, 2005, p730 - 738 Journal Article, 2005 TARA - Full Text URL

Loscher CE, Draper E, Leavy O, Kelleher D, Mills KHG & Roche HM , Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction, Journal of Immunology, 175, (8), 2005, p4990 - 4998 Journal Article, 2005 URL TARA - Full Text

Nolan Y, Maher FO, Clarke RM, Brady MT, Bolton AE, Mills KHG, Lynch MA, Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus., Journal of Biological Chemistry, 280, (10), 2005, p9354 - 9362 Journal Article, 2005 DOI

Modified bacterial toxins in, editor(s)Charles J Hackett & Donald A Harn Jr, , Vaccine Adjuvants: Immunological and Clinical Principles., Publisher Humana, 2005, pp296 , [Lavelle EC., Leavy O. Mills KHG. ] Book Chapter, 2005

Evasion of immune responses by bacteria. in, editor(s)S. Kaufmann and M. Steward , Topley and Wilson's Microbiology and Microbial Infections: Immunology Volume, London, Hodder Arnold Publishers Ltd, 2005, pp645 - 674, [Mills, K.H.G. and Boyd, A] Book Chapter, 2005

Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KHG, Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines, Journal of Infectious Diseases, 192, (9), 2005, p1628 - 1633 Journal Article, 2005 TARA - Full Text

Noone, C.M. Lewis, EA, Frawely, A.B., Newman, R.W., Mahon, B.P., Mills, K.H.G. and Johnson, P.A. , Novel mechanism of immunosuppression by influenza virus haemagglutinin: selective suppression of IL-12p35 transcription in murine bone marrow-derived dendritic cells., Journal of General Virology, 86, (7), 2005, p1885-1890 Journal Article, 2005 DOI TARA - Full Text

McGuirk, P., Higgins, SC, Mills, K.H.G. , Regulatory cells and the control of respiratory infection. , Current Allergy and Asthma Reports, 5, (1), 2005, p51 - 55 Journal Article, 2005 URL

Huo ZM, Sinha R, McNeela EA, Borrow R, Giemza R, Cosgrove C, Heath PT, Mills KHG, Rappuoli R, Griffin GE, Lewis DJM, Induction of protective serum meningococcal bactericidal and diphtheria-neutralizing antibodies and mucosal immunoglobulin a in volunteers by nasal insufflations of the Neisseria meningitidis serogroup C polysaccharide-CRM197 conjugate vaccine mixed with chitosan, Infection and Immunity, 73, (12), 2005, p6256 - 6265 Journal Article, 2005 DOI

Mills, K.H.G., Mahon, B., Griffin, F., Ryan, M, Genetic Institute / Wyeth, IL-12 as an adjuvant for Bordetella pertussis vaccines., 2005, US patent application 11/071,352. Pub No US2005/0158276 A1; US6929794 - 2005-08-16; US2005158276 - 2005-07-21; JP2005112865 - 2005-04-28. Patent, 2005

Lelivelt CL, McCabe MS, Newell CA, Desnoo CB, van Dun KM, Birch-Machin I, Gray JC, Mills KH, Nugent JM., Stable Plastid Transformation in Lettuce (Lactuca sativa L.), Plant Molecular Biology, 58, 2005, p763-774 Journal Article, 2005 URL DOI

Loscher, CL Leavy, O. Kelleher, D, *Mills, K.H.G and *Roche, H.M. *Equal contribution, Conjugated linoleic acid suppresses NFkB activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction., Journal of Immunology, 175, (8), 2005, p4990 - 4998 Journal Article, 2005 URL

Lavelle EC, Jarnicki A, McNeela E, Armstrong ME, Higgins SC, Leavy O, Mills KHG, Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent, Journal of Leukocyte Biology, 75, (5), 2004, p756 - 763 Journal Article, 2004 DOI TARA - Full Text

Mills, K.H.G. and McGuirk, P., Antigen-specific regulatory T cells - their induction and role in infection, Seminars in Immunology, 16, (2), 2004, p107 - 117 Journal Article, 2004 URL

Lavelle, E., McGuirk and Mills, K.H.G., Molecules of infectious agents as immunomodulatory drugs, Current Topics in Med. Chem., 4, (5), 2004, p499 - 508 Journal Article, 2004 URL

Byrne P, McGuirk P, Todryk S, Mills KHG, Depletion of NK cells results in disseminating lethal infection with Bordetella pertussis associated with a reduction of antigen-specific Th1 and enhancement of Th2, but not Tr1 cells, EUROPEAN JOURNAL OF IMMUNOLOGY, 34, (9), 2004, p2579 - 2588 Journal Article, 2004 URL DOI

McNeela, E., Jabbal-Gill, E. Illum, L., Pizza, Rappuoli, R., Podda, A., Lewis, D.M. and Mills, K.H.G., Intranasal immunization with genetically detoxified diphtheria toxin induces T cell responses in humans: correlation between toxin neutralizing antibody and Th2 responses, VACCINE, 22, (8), 2004, p909 - 914 Journal Article, 2004 URL DOI

Mills, K.H.G., Keogh, B and McGuirk, P, Cell-based therapies., 2004, UK patent application Patent, 2004

Lavelle, E.C., McGuirk, P. and Mills, K.H.G. , Molecules of Infectious Agents as Immunomodulatory Drugs, Current Medicinal Chemistry , 4, (5), 2004, p499 - 508 Journal Article, 2004 URL

Bowe, F., Lavelle, E.C., McNeela, E. A., Hale, C., Clare, S., Arico, B., Giuliani, M.M., Rae, A., Huett, A., Rappuoli, R., Dougan, G. and Mills, K. H.G., Mucosal vaccination against serogroup B meningococcus:Induction of bactericidal antibodies and cellular immunity following intranasal immunization with NadA of Neisseria meningitidis and mutants of Escherichia coli heat-labile enterotoxin, Infection and Immunity, 72, (7), 2004, p4052 - 4060 Journal Article, 2004 DOI TARA - Full Text

K.H.G. Mills, Regulatory T cells: friend or foe in immunity to infection. , Nature Reviews Immunology, 4, 2004, p841 - 855 Journal Article, 2004 TARA - Full Text DOI

Mills, K.H.G., Keogh, B and McGuirk, P, Methods for suppressing immune responses to biological agents. , 2004, UK patent application Patent, 2004

Ross, P.J., Lavelle, E.C., Mills, K.H.G. and A.P. Boyd., Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells, Infection and Immunity, 72, (3), 2004, p1568 - 1579 Journal Article, 2004 DOI TARA - Full Text

Higgins, S., Lavelle, E., McCann, C., Keogh, B., McNeela, E, Byrne, P., O'Gorman, B., Jarnicki, A., McGuirk, P. and Mills, K.H.G., Toll-like receptor 4-mediated innate IL-10 activates antigen-specific regulatory T cells and confers resistance to Bordetella pertussis by inhibiting inflammatory pathology, Journal of Immunology, 171, (6), 2003, p3119 - 3127 Journal Article, 2003 TARA - Full Text URL

Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190 Journal Article, 2003 DOI URL

Kelly Á, Vereker E, Brady M. Barry C, Loscher C, Mills KHG, Lynch MA., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462 Journal Article, 2003 TARA - Full Text DOI URL

Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562 Journal Article, 2003 URL DOI

Mills, K.H.G. and Brady, M., Hepatitis C virus (HCV) proteins., 2003, 2003/0279 Patent, 2003

Mills, H.H.G., McGuirk, P., Keogh, B., FHA in the prophylaxis of immune mediated disorders., 2003, 2003/076 Patent, 2003

Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124 Journal Article, 2003 DOI URL

Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190 Journal Article, 2003 DOI URL

Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33 Journal Article, 2003 URL DOI

Induction and detection of T cell responses in, editor(s)A. Robinson, M.J. Hudson, and M. P. Cranage , Methods in Molecular Medicine. Vol 87: Vaccine protocols, 2nd Edition, NJ, USA, Humana Press Inc., 2003, pp255 - 278, [Mills, K.H.G.] Book Chapter, 2003

Mills, K.H.G., Cosgrove, C., McNeela E.A., Sexton, A., Giemza, R., Jabbal-Gill, I., Church, A., Lin, W., Illum, L., Podda, A., Rappuoli, R., Pizza, M. Griffin, G.E. and Lewis, D.J.M., Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a, Infection and Immunity, 71, (2), 2003, p726 - 732 Journal Article, 2003 DOI TARA - Full Text

Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33 Journal Article, 2003 URL DOI

Mills, K.H.G., Boyd, A.P., Ross, P.J. and Lavelle, EC., , CyaA in the prophylaxis/treatment of inflammatory and immune-mediated disorders., 2003 Patent, 2003

Kelly, A., Vereker, E., Brady, M., Brooks, C., Loscher, C, Mills, K.H.G. and Lynch, M.A., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta induced inhibition of long term potentation in the rat dentate gyrus, J. Biol Chem., 278, (21), 2003, p19453 - 19462 Journal Article, 2003 DOI URL

Lavelle, E., McNeela, E., Armstrong, M., Leavy, O., Higgins, S.C. and Mills K.H.G., Cholera toxin promotes the induction of regulatory T cells by modulation dendritic cell activation, The Journal of Immunology, 171, 2003, p2384 - 2392 Journal Article, 2003 URL TARA - Full Text

Brady, M. MacDonald, A., Rowan, A. and Mills K.H.G., Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes, EUROPEAN JOURNAL OF IMMUNOLOGY, 33, (12), 2003, p3448 - 3457 Journal Article, 2003 URL DOI

Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562 Journal Article, 2003 DOI URL

Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124 Journal Article, 2003 DOI URL

McGuirk, P and Mills K.H.G., PATHOGEN-SPECIFIC REGULATORY T CELLS PROVOKE A SHIFT IN THE TH1/TH2 PARADIGM IN IMMUNITY TO INFECTIOUS DISEASES, TRENDS IN IMMUNOLOGY, 23, 2002, p450-455 Review, 2002 DOI URL

Peter McGuirk, Chantelle McCann, and Kingston H.G. Mills, Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells: A Novel Strategy for Evasion of Protective T Helper Type 1 Responses by Bordetella pertussis, Journal of Experimental Medicine , 195, (2), 2002, p221 - 231 Journal Article, 2002 TARA - Full Text DOI

Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J, Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: A role for Th1 cells in the protective immunity , Journal of Neuroimmunology , 125, 2002, p15 - 22 Journal Article, 2002 DOI

Lavelle EC, Grant G, Pusztai A, Pfüller U, Leavy O, McNeela E, Mills KH, O'Hagan DT., Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2., Journal of Immunology, 107, (2), 2002, p268 - 274 Journal Article, 2002 TARA - Full Text DOI

MACDONALD, AJ, CD4 T HELPER TYPE 1 AND REGULATORY T CELLS INDUCED AGAINST THE SAME EPITOPES ON THE CORE PROTEIN IN HEPATITIS C VIRUS-INFECTED PERSONS, JOURNAL OF INFECTIOUS DISEASES, 185, 2002, p720 - 727 Journal Article, 2002 URL DOI

MILLS, KHG, LIVE VECTORS: ARE SAFE BUT EFFECTIVE VACCINES POSSIBLE?, 2002, - 854-855 Miscellaneous, 2002 DOI

McNeela, E. and Mills, K.H.G., Manipulating the immune system - humoral versus cell-mediated immunity, Advanced Drug Delivery Reviews, 51, 2001, p41 - 52 Journal Article, 2001 DOI URL

Ryan, E.R., Daly, L. and Mills K.H.G., Immunomodulators and delivery systems for vaccination by mucosal routes, Trends Biotech., 19, (8), 2001, p293 - 304 Journal Article, 2001 DOI URL

P.A. Johnson, M. Conway, J. Daly, C. Nicolson J. Robertson K.H.G. Mills., Influenza HA DNA induces Th1 cells and protection despite limited antibody responses. Options for the Control of Influenza virus., International Congress Series , 1219, 2001, pp911-915 Conference Paper, 2001 URL DOI

O'Neill, Mills, K.H.G. and Dalton, J.P., Fasciola hepatica cathepsin L cysteine proteinase suppresses Bordetella pertussis-specific IFN-gamma production in vivo, Parasite Immunol., 23, (10), 2001, p541 - 548 Journal Article, 2001 DOI URL

Sheila Donnelly, Christine E. Loscher, Marina A. Lynch, and Kingston H. G. Mills, Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination, Infection and Immunity, 69, (7), 2001, p4217 - 4223 Journal Article, 2001 TARA - Full Text DOI

CONWAY, MA, PROTECTION AGAINST BORDETELLA PERTUSSIS INFECTION FOLLOWING PARENTERAL OR ORAL IMMUNIZATION WITH ANTIGENS ENTRAPPED IN BIODEGRADABLE PARTICLES: EFFECT OF FORMULATION AND ROUTE OF IMMUNIZATION ON INDUCTION OF TH1 AND TH2 CELLS, VACCINE, 19, 2001, p1940 - 1950 Journal Article, 2001 DOI URL

Mills, K.H.G., Review: Immunity to Bordetella pertussis, Microbes and Infection, 3, 2001, p293 - 304 Journal Article, 2001 URL DOI

Pizza, M., Giuliani, M.M., M.R. Fontana, E. Monacai, G. Douce, G. Dougan, K.H.G. Mills, R. Rappuoli, and G. Del Giudice., Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants, Vaccine, 19, 2001, p2534 - 2541 Journal Article, 2001 DOI URL

Johnson, P.A., Conway, M., Daly, J., Nicolson C., Robertson J. and Mills K.H.G., Plasmid DNA coding for influenza virus haemagglutinin induces Th1 cells and protection against respiratory infection despite its limited ability to generate antibody responses, Journal of General Virology, 81, 2000, p1737-1745 Journal Article, 2000 TARA - Full Text URL

McGuirk P. and Mills K.H.G., Local cellular immunity to infection in the respiratry tract, Mucosal Immunology Update, 8, (2), 2000, pp8 - 10 Conference Paper, 2000

Fisch, P., Mills, K.H.G. and vanMeerwijk, J.P.M., Molecular Determinants of T cell Immunity, The Immunologist, 8, 2000, pp114 - 118 Conference Paper, 2000

McGuirk P. Johnson, Ryan, E.J. and Mills K.H.G., Filamentous Haemagglutinin and pertussis toxin from Bordetella pertussis modulate immune responses to unrelated antigens, J. Infect. Dis., 182, 2000, p1286 - 1288 Journal Article, 2000 DOI URL

Christine E. Loscher, Sheila Donnelly, Marina A. Lynch Kingston H. G. Mills, Induction of inflammatory cytokines in the brain following respiratory infection with bordetella pertussis, Journal of Neuroimmunology, 102, (2), 2000, p172 - 181 Journal Article, 2000 URL DOI

McGuirk, P. and Mills, K.H.G., A regulatory role for IL-4 in differential inflammatory responses in the lung following infection of mice primed with Th1- or Th2-inducing pertussis vaccines, Infection and Immunity, 68, (3), 2000, p1383 - 1391 Journal Article, 2000 URL TARA - Full Text

Ryan E.J., Nilsson, L, Kjellman, N.-I. M., Gothefors, L and Mills K.H.G., Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens, Clinical and Experimental Immunology, 121, (2), 2000, p193 - 200 Journal Article, 2000 DOI TARA - Full Text

RYAN, EJ, Mills, KH, MODULATION OF INNATE AND ACQUIRED IMMUNE RESPONSES BY ESCHERICHIA COLI HEAT-LABILE TOXIN: DISTINCT PRO- AND ANTI-INFLAMMATORY EFFECTS OF THE NONTOXIC AB COMPLEX AND THE ENZYME ACTIVITY, JOURNAL OF IMMUNOLOGY, 165, 2000, p5750 - 5759 Journal Article, 2000 URL

Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, and Marina A. Lynch, Interleukin-1â-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine , Journal of Neuroimmunology, 111, (1-2), 2000, p68 - 76 Journal Article, 2000 URL DOI

McNeela, EA, O'Connor, D., Jabbal-Gill, I., Illum, L., Davis, S.S., Pizza, M., Peppoloni, S., Rappuoli, R. and Mills, K.H.G., A mucosal vaccine against diphtheria: Formulation of cross reacting material (CRM197) of diphtheria toxin with chitosan enhances local and systemic antibody and Th2 responses following nasal delivery, Vaccine, 19, (9-10), 2000, p1188 - 1198 Journal Article, 2000 DOI URL

O'Neill, S.M., Brady, M.T., Callanan, J.J., Mulcahy, G, Joyce, P., Mills, K.H.G. and Dalton, J.P., Fasciola hepatica infection downregulates Th1 responses in mice, Parasite Immunol., 22, (3), 2000, p147 - 156 Journal Article, 2000 DOI URL

Mahon, B.P., Brady, M.T. and Mills, K. H. G., Protection against Bordetella pertussis in mice in the absence of circulating antibody; implications for long term immunity in children, J. Infect. Dis., 181, 2000, p2087 - 2091 Journal Article, 2000 DOI URL

Mills, K.H.G. , A murine model for control and new developments in pertussis vaccination, Pharmeuropa, Biological beyond 2000. Proceedings of International Conference on 'Challenge for quality standards in an evolving field', Council of Europe, Strasburg, France, 2000, pp205 - 210 Conference Paper, 2000

McGuirk, P. and Mills, K.H.G., Direct anti-inflammatory effect of a bacterial virulence factor: IL-10-dependent suppresssion of IL-12 production by filamentous haemagglutinin from Bordetella pertussis, Eur. J. Immunol., 30, 2000, p415 - 422 Journal Article, 2000 DOI URL

Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, Marina A. Lynch, INTERLEUKIN-1 BETA-DEPENDENT CHANGES IN THE HIPPOCAMPUS FOLLOWING PARENTERAL IMMUNIZATION WITH A WHOLE CELL PERTUSSIS VACCINE, JOURNAL OF NEUROIMMUNOLOGY, 111, 2000, p68 - 76 Journal Article, 2000 DOI URL

E. J. Ryan, E. McNeela, M. Pizza, R. Rappuoli, L. O'Neill and K. H. Mills, Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity, Journal of Immunology (Baltimore, Md, 165, (10), 2000, p5750-9 Journal Article, 2000 URL TARA - Full Text URL

Ryan, E.J. McNeela, E, Murphy, G., Stewart, H., O'Hagan, D. Pizza, M, Rappuoli, R. and Mills K.H.G., Mutants of E. coli heat labile toxin act as effective mucosal adjuvants for nasal delivery of an acellular pertussis vaccine: differential effects of the non-toxic AB complex and enzyme activity on Th1 and Th2 cells, Infection and Immunity, 67, 1999, p6270 - 6280 Journal Article, 1999 URL URL TARA - Full Text

Brady, M.T. O'Neill, S.M. Dalton, J.P. and Mills, K.H.G., Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis, Infection and Immunity, 67, 1999, p5372 - 5378 Journal Article, 1999 URL TARA - Full Text

Moore, A., McCarthy, L. and Mills, K.H.G., The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a recombinant HIV protein from Th2 to Th1, Vaccine, 17, (20-21), 1999, p2517 - 2527 Journal Article, 1999 URL DOI

O'Keeffe J, Mills K. H.G., Jackson J, Feighery C, T cell proliferation, MHC class II restriction and cytokine products of gliadin-stimulated peripheral blood mononuclear cells (PBMC), Clin. Exp. Immunol., 117, 1999, p269 - 276 Journal Article, 1999 DOI URL

Almond, N, Jenkins, A., Jones, S., Silvera, P., Kent, K., Mills, K.H.G. and Stott, E.J., The Appearance of escape variants in vivo does not account for the failure of recombinant envelope Vaccines to protect against simian immunodeficiency virus, Journal of General Virology, 80, 1999, p2375 - 2382 Journal Article, 1999 URL

Mills, K.H.G. Ryan, M., McGuirk, Griffin, F., Murphy, G. and Mahon, B., The immunology of Bordetella pertussis infection, Biologicals, 27, 1999, pp77 Conference Paper, 1999

Murine T cell culture in, editor(s)Rowland Jones, S and McMichael A. , Lymphocytes - A Practical Approach, Oxford, IRL Press, 1999, pp95 - 134, [Mills, K.H.G.] Book Chapter, 1999

Mahon, B.P. and Mills, K.H.G., Interferon-gamma mediated immune effector mechanisms against Bordetella pertussis, Immunol. Letts., 68, 1999, p213 - 217 Journal Article, 1999

Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina , Glycerol-induced seizure: Involvement of IL-1[beta] and glutamate, NEUROREPORT, 10, (9), 1999, p1821 - 1825 Journal Article, 1999 URL

Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina, GLYCEROL-INDUCED SEIZURE: INVOLVEMENT OF IL-1 BETA AND GLUTAMATE, NEUROREPORT, 10, (9), 1999, p1821 - 1825 Journal Article, 1999 URL

Mills, K.H.G., Ryan, M., Ryan, E. and Mahon, B. P., A murine model in which protection correlates with pertussis vaccine efficacy in children demonstrates complementary roles for humoral and cell mediated immunity in protection against Bordetella pertussis, Infection and Immunity, 66, (2), 1998, p594 - 602 Journal Article, 1998 URL TARA - Full Text

Mills, K.H.G., Brady, M. Ryan, E. and Mahon B.P., A respiratory challenge model for infection with Bordetella pertussis: application in assessment of pertussis vaccine potency and in definition of the mechanism of protective immunity, Dev. Biol. Stand., 95, 1998, p31 - 41 Journal Article, 1998

Johnson, P. A., Conway, M., Cox-Brokstad, R, Haaheim, L., Daly, J., Robertson, J. and Mills, K.H.G., Selective induction of Th1 cells with plasmid DNA coding for influenza virus haemagglutinin, Proceeding of European 2nd Biotechnology meeting on Vaccinology, edited by P. Roy and C. Leclerc. , 1998, pp42 - 43 Conference Paper, 1998

Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH., Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine., Annals of the New York Academy of Sciences, 856, 1998, p274 - 277 Journal Article, 1998 URL

Mills, K.H.G., Adjuvants for Vaccines: General considerations. Rapporteur's Summary., Modulation of the immune response to vaccine antigens, Dev. Biol. Stand., 92, (29), 1998 Conference Paper, 1998

McGuirk, P. Mahon, B.P., Griffin, F. and Mills K.H.G., Compartmentalization of T cell responses following infection with B. pertussis: hyporesponsiveness of lung T cell are associated with modulated expression of the costimulatory molecule CD28, Eur. J. Immunol., 28, (1), 1998, p153 - 163 Journal Article, 1998 URL DOI

Ryan, M. McCarthy, L., Mahon, B, Rappuoli, R. Mills K.H.G., Pertussis Toxin potentiates Th1 and Th2 responses to co-injected antigen: adjuvant action is associated with enhanced regulatory cytokine production and expression of the co-stimulatory molecules B7-1, B7-2 and CD28, International Immunology, 10, (4), 1998, p651 - 662 Journal Article, 1998 TARA - Full Text URL

Brady, M, Mahon B.P. and Mills, K. H. G., Pertussis infection and vaccination induces Th1 cells and does not enhance allergy, Immunol. Today, 19, 1998, p534 Journal Article, 1998 URL DOI

Mahon, B. P., Johnson, P. Moore, A. and Mills, K.H.G., Approaches to New Vaccines, Crit. Rev. Biotech., 18, (1), 1998, p257 - 281 Journal Article, 1998

Ryan, M. Murphy, G Nilsson, L., Shackley, F., Gothefors, L., Ømar, K., Miller, E. Storsaeter, J. and Mills, K.H.G., Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children, Immunology, 93, (1), 1998, p1 - 10 Journal Article, 1998 DOI TARA - Full Text

Ryan, M., Murphy, G., Gothefors, L., Nilsson, L, Storsaeter J. and Mills, K.H.G., Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 Th cells, J. Infect. Dis., 175, 1997, p1246 - 1250 Journal Article, 1997 URL

Mc Guirk P., Mahon B.P., Griffin, F. and Mills K.H.G.(ed.), Local cellular immunity to the respiratory pathogen Bordetella pertussis: role of costimulatory molecules, Biochem. Soc. Trans., 25, (1), 1997, 124S p Proceedings of a Conference, 1997

Mahon B.P, Griffin F., Sheahan, B. and Mills, K.H.G., Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- × receptor or immunoglobulin Ý chain genes, Journal of Experimental Medicine, 186, (11), 1997, p1843 - 1851 Journal Article, 1997 TARA - Full Text URL

Ryan, M, and Mills K.H.G., The role of the S-1 and B-oligomer components of pertussis toxin in its adjuvant properties for Th1 and Th2 cells, Biochem. Soc. Trans., 25, (1), 1997, p126S Journal Article, 1997

Mahon B. P. Ryan, M. Griffin, F., and Mills K.H.G.(ed.), Mechanisms of immunity to the respiratory pathogen Bordetella pertussis in normal and gene knockout mice: clearance of primary infection is not enhanced by therapeutic IL-12, Biochem. Soc. Trans., 25, (1), 1997, 341S p Proceedings of a Conference, 1997

Ryan, M., Gothefors, Storsaeter J. and Mills, K. H. G., Bordetella pertussis-specific Th1/Th2 cells generated following respiratory infection or immunization with an acellular vaccine: comparison of the T cell cytokine profiles in infants and mice, Dev. Biol. Stand., 89, 1997, p251 - 259 Journal Article, 1997

Induction and detection of T cell responses in, editor(s)A. Robinson , Methods in Molecular Medicine - Vaccine protocols, NJ, USA, Humana Press Inc, 1996, pp197 - 221, [Mills, K.H.G.] Book Chapter, 1996

Barnard, A, Mahon, B.P., Watkins, J., Redhead, K. and Mills, K.H.G., Th1/Th2 cell dichotomy in acquired immunity to Bordetella pertussis: variables in the in vivo priming and in vitro cytokine detection techniques affect the classification of T cell subsets as Th1, Th2 or Th0, Immunology, 87, (3), 1996, p372 - 380 Journal Article, 1996 TARA - Full Text URL

Mahon, B. P., Ryan, M. Griffin, F. Mills, K.H.G., Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting the induction of Th1 cells, Infection and Immunity, 64, (12), 1996, p5295 - 5301 Journal Article, 1996 TARA - Full Text URL

Mahon, B.P., Katrak, K., Nomoto, A., Macadam A., Minor, P.D. and Mills, K.H.G., Poliovirus-specific CD4+ Th1 clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor, Journal of Experimental Medicine, 181, (4), 1995, p1285 - 1292 Journal Article, 1995 TARA - Full Text

Moore, A, McQuirk P, Adams S., Jones, W.C, McGee, J.P., O'Hagan, D. and Mills, K.H.G., Induction of HIV-specific CD8+ CTL and CD4+ Th1 cells by immunization with recombinant gp120 entrapped in biodegradable microparticles, Vaccine, 13, 1995, p1741 - 1749 Journal Article, 1995 DOI URL

Cahill, E.S., O'Hagan, D.T., Illum, L., Barnard, A., Mills, K.H.G. and Redhead, K., Immune responses and protection against Bordetella pertussis infection after intranasal immunization of mice with filamentous haemagglutinin in solution or incorporated in biodegradable microparticles, Vaccine, 13, 1995, p455 - 462 Journal Article, 1995 URL DOI

Mills, K.H.G. and Jones W.C. , CD4+ T cell responses to Simian immunodeficiency virus, Cur. Topics Immunol. Microbiol., 188, 1994, p161 - 174 Journal Article, 1994

Animal models in the development of AIDS vaccines in, editor(s)M. Girard and L. Valette , Retroviruses of human AIDS and related animal diseases, Pasteur Merieux, 1994, pp131 - [Stott, E.J., Almond, N., Kent, K.A., Chan, W.L., Cranage, M.P., Kitchin, P.A., Mills, K.H.G., Page, M., and Rud, E] Book Chapter, 1994

Mammalian cell cloning in, editor(s)J. Davis , Basic Animal cell culture: A practical approach, IRL Press at Oxford University press, 1994, pp181 - 222, [Hayashi, I., Hayashi, J., Hoshi, H., Kawamoto, T., Mc Keehan, W., Matsuzaki, R. Mills, K.H.G. , Okamoto, T., Serrero, G., Sussman D., and Kan, M.] Book Chapter, 1994

Kent K.A., Kitchin, K., Mills, K.H.G. Page, M., Taffs, F., Corcoran, T., Silvera, P., Flanagan B., Powell, C., Rose, J. Ling, C., Aubertin A.M. and Stott, E.J., Passive immunization of cynomolgus macaques with immune sera or a pool of neutralizing monoclonal antibodies failed to protect against challenge with SIV mac251, AIDS Res. Hu. Retrovir., 10, (2), 1994, p189 - 194 Journal Article, 1994

Mills, K.H.G., Barnard, A.L., Watkins, J. and Redhead, K., Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model, Infect. Immun., 61, (2), 1993, p399 - 410 Journal Article, 1993 TARA - Full Text URL

Redhead, K., Barnard, A., Watkins, J. and Mills, K.H.G., Effective immunization against Bordetella pertussis respiratory infection of mice is dependant on the induction of cell mediated immunity, Infection and Immunity, 61, (8), 1993, p3190 - 3198 Journal Article, 1993 URL TARA - Full Text

Mills, K.H.G., Barnard, A., Watkins, J. and Redhead, K., The critical role of T cells in the induction of protective immunity to B. Pertussis with acellular vaccines based on recombinant pertussis toxin, Biologicals, 21, 1993, p19 - 20 Journal Article, 1993 DOI URL

T cells and protective immunity to human and simian immunodeficiency viruses in, editor(s)D.B. Thomas, Marcel Decker , Viruses and the cellular immune response, New York, 1993, pp127 - 164, [Mills, K.H.G.] Book Chapter, 1993

O'Hagan, D.T. Mc Gee, J.P., Holmgren, J., Mowat, A., Donachie A.M., Mills, K.H.G., Gaisford, W., Rahman, D. and Challcombe, S.J., Biodegradable microparticles for oral immunization, Vaccine, 11, 1993, p149 - 157 Journal Article, 1993 URL DOI

Redhead, K., Watkins, J., Barnard, A. and Mills, K.H.G., Comparison of humoral and cellular immune responses to pertussis immunization and infection in a murine model, Biologicals, 21, 1993, p18 - 19 Journal Article, 1993 URL DOI

Cellular and humoral immune responses to poliovirus and tetanus following priming vaccination of SIV infected macaques in, Molecular pathological aspects of animal models of HIV infection, Basel, Karger Medical and Scientific Publishers, 1993, pp75 - 85, [Mills, K.H.G., Jones, W.C., Mahon, B.P., Katrak, K., Taffs, F., Stott, E.J. and Page, M.] Book Chapter, 1993

Barnard, A.L., Redhead, K. and Mills, K.H.G., Induction of Th1 and Th2 cells by immunization or respiratory infection with Bordetella pertussis, Biologicals, 21, (1), 1993, p32 Journal Article, 1993 DOI URL

Mills, K.H.G., Redhead, K., Cellular immunity in pertussis , Journal of Medical Microbiology, 39, 1993, p163 - 164 Journal Article, 1993

Mills, K.H.G., Page, M., Kitchin, P., Chan, L., Jones, W., Silvera, P., Corcoran, T., Flanagan, B., Ling, C., Thiriart, C., DeWilde, M., Bruck, C., Rud, E. Clark, B. & Stott, E.J., Immunization of macaques with SIV env recombinants: Specificity of T cell and antibody responses and evaluation of protective efficacy, J. Med. Primatol., 22, 1993, p20 - 28 Journal Article, 1993

Vaccination of macaques against SIV infection and the significance of host (C8166) cell components in, editor(s)Des, F. Brown, R. Chanock, H.S. Ginsberg and R. Lerner. , Vaccines 93: Modern approaches to new vaccines including the prevention of AIDS, New York, Cold Spring Harbor Laboratory, 1993, pp71 - 76, [Kitchin, P. Mills, K.H.G., Page, M. Taffs, F., Chan, W.L., Cranage, M., Farrar, G., Greenway, P., and Stott, J.] Book Chapter, 1993

Jones, W.C., Barnard, A.L., Slade, A. and Mills, K.H.G., Heterogeneity in the recognition of the SIV envelope glycoprotein by CD4+ T cell clones from immunized macaques, J. Immunol., 149, 1992, p3120 - 3126 Journal Article, 1992 URL

Katrak, K., Mahon, B.P., Jones, W., Brautigam, S. and Mills, K.H.G., Preparative separation of foreign antigens for highly efficient presentation to T cells in vitro, J. Immunol. Methods, 156, 1992, p247 - 254 Journal Article, 1992 URL

Cranage, M., Stott, J., Mills, K.H.G., Ashworth, T., Taffs, F., Farrar, G., Chan, W.L., Page, M., Kithcin, P. and Greenaway, P., Vaccine studies with the 32H reisolate of SIV mac251: an overview., AIDS Res. Hu. Retrovir., 8, 1992, p1479 - 1481 Journal Article, 1992

The primate (non-human) immune system in, editor(s)I. Roitt and P. Delves, W.B. , Encyclopaedia of Immunology, Sanders Scientific Publishers, 1992, pp1269 - 1292, [Mills, K.H.G.] Book Chapter, 1992

Cellular immune responses to pertussis toxin in aerosol infected mice in, editor(s)Witholt et al , Bacterial protein toxins, Gustav Fischer, 1992, pp306 - 307, [Redhead, K., Barnard, A., Watkins, J. and Mills, K.H.G.] Book Chapter, 1992

Mahon, B.P., Katrak, K. and Mills, K.H.G. , Poliovirus-specific murine CD4+ T cell clones recognise serotype specific epitopes on VP1 and VP3 and cross reactive epitopes on VP4, J. Virol., 66, 1992, p1479 - 1481 Journal Article, 1992

Mills, K.H.G., Page, M., Chan, W.L., Kitchin, P., Stott, E.J., Taffs, F., Jones, W et al., Protection against SIV infection in macaques by immunization with inactivated virus from the BK28 molecular clone but not with BK28-derived recombinant env and gag proteins, J. Med. Primatol., 21, 1992, p50 - 58 Journal Article, 1992

Stott, E.S., Chan, W.L., Mills, K.H.G., Page, M., Taffs, F., Cranage, M., Greenaway P and Kitchin P., Protection of cynomolgus macaques against simian immunodeficiency virus by a whole fixed infected cell vaccine, Lancet, 336, 1991, p1536 - 1541 Journal Article, 1991

Stott, E.J., Kitchin, P.A., Page, M., Flanagan, B., Taffs, L.F., Chan, W.L., Mills, K.H.G., Silvera, P. and Rodgers, A., Anti cell antibody in macaques., Nature, 353, (393), 1991 Journal Article, 1991 DOI

Mills, K.H.G., Barnard A.L., Williams, M., Stott, J.F., Silvera, P., Page, M., Taffs, F., Kingsman, A.S., Adams, S.E., Almond, N., Kitchin, P.A., Jones, W.C., Vaccine-induced CD4+ T cells against the simian immunodeficiency virus gag protein: epitope specificity and relevance to protective immunity, J. Immunol., 147, 1991, p3560 - 3567 Journal Article, 1991 URL

Page, M., Mills, K.H.G., Schild, G.C., Ling, C., Patel, V., McKnight, A., Barnard, A.L., Dilger, P. and Thorpe, R., Studies on the immunogenicity of CHO cell-derived recombinant gp120 (HIV1-IIIb)., Vaccine, 9, 1991, p47 - 52 Journal Article, 1991

Katrak, K., Mahon, B.P., Minor, P.D. and Mills, K.H.G., Cellular and humoral immune responses to poliovirus in mice: a role for helper T cells in heterotypic immunity to poliovirus, Journal of General Virology, 72, 1991, p1093 - 1098 Journal Article, 1991 TARA - Full Text URL

Mills, K.H.G., Redhead, K. and Watkins, J., T-cell immunity in protection against Bordetella pertussis infection in mice, J. Med. Microbiol., 35, 1991, p175 - 176 Journal Article, 1991

Prospects for immunization against HIV infection: Immunology of HIV infection in, A.G. Bird , Immunology and Medicine Series. Vol. 17, Kluwer Academic Publishers, 1991, pp155 - 176, [Mills, K.H.G.] Book Chapter, 1991

Vaccination against simian-immunodeficiency virus infection of macaques in, editor(s)M. Girard and L. Valette , Retroviruses of human AIDS and related animal diseases. Sixieme colloque des cent gardes 1991, Pasteur Merieux, 1991, pp261 - 265, [Stott, J., Cranage, M., Kitchin, P., Farrar, G., Taffs, F., Ashworth, E., Page, M., Chan, L., Baskerville, A., Greenaway, P. and Mills, K.H.G.] Book Chapter, 1991

Burnette, W.N., Mar, V.L., Bartley, H.R., Mills, K.H.G. et al., The Molecular engineering of pertussis toxoid, Dev. Biol. Stand., 73, 1991, p75 - 78 Journal Article, 1991

Induction of HIV-specific immune responses in primates: fine specificity of antibody and helper T-cell recognition of the HIV-p24 protein. in, editor(s)F. Brown, R. Chanock, H.S. Ginsberg and R. Lerner , Vaccines 90: Modern approaches to new vaccines including the prevention of AIDS, Cold Spring Harbor Laboratory, New York, 1990, pp213 - 218, [Mills, K.H.G., Barnard, A.L., Mahon, B.P., Kitchin, P.A., Adams, S.E., Kingsman, A.M. and Kingsman, A.J.] Book Chapter, 1990

Mills, K.H.G., Barnard, A., Watkins, S. and Redhead, K., Specificity of the T cell response to Bordetella pertussis in aerosol infected mice, Proceedings of the 6th international symposium on pertussis, Dept. Health and Human Services, United States Public Health Service, Bethesda, Ma, USA, 1990, pp166 - 174 Conference Paper, 1990

Almond, N., Page, M., Mills, K.H.G., Jerkins, A., Ling, C., Thorpe, R. and Kitchin, P., The production and purification of PCR derived recombinant simian immunodeficiency virus p27 gag protein: its use in detecting serological and T-cell responses in macaques., J. Virol. Methods, 28, 1990, p321 - 326 Journal Article, 1990

Mills, K.H.G., Kitchin, P.A., Mahon, B.P., Barnard, A.L., Adams, S.E., Kingsman, S.M. and Kingsman, A.J., HIV p24-specific T cell clones from immunized primates recognize highly conserved regions of HIV-1, J. Immunol., 144, 1990, p1677 - 1683 Journal Article, 1990 URL

Titration of SIV MAC 251 (32H isolate) in cynomolgus macaques for use as a challenge in vaccination studies in, editor(s)H. Schellekens and M.C. Horzinek , Animal models for AIDS, Elsevier Science Publishers, 1990, pp115 - 129, [Kitchin, P.A., Cranage, M.P., Almond, N., Barnard, A., Baskerville, A., Corcoran, T., Fromlhloc, C. Greenway, P., Grief, C., Jerkins, A., Kent, K., Mahon, B., Mills, K.H.G., Page, M., Silvera, P., Szotyori, Z., Taffs, F. and Stott, E.J.] Book Chapter, 1990

Skehel, J.J., Barnett, B.C., Burt, D.S., Daniels, R.S., Douglas, A.R., Graham, C.M., Hodgson, J., Knossow, M., Mills, K.H.G., Riska, P.F., Thomas, D.B., Weis, W.,Wiley, D.C. & Wrigley, N.C., Immune recognition of influenza virus haemagglutinin, Philos. Trans. Royal Soc. London B., 323, 1989, p479 - 483 Journal Article, 1989

Burt, D.S., Mills, K.H.G., Skehel, J.J. and Thomas, D.B., Diversity of the class II (I-Ak/I-Ek) restricted T-cell repertoire for influenza haemagglutinin and antigenic drift: six non-overlapping epitopes on the HA1 sub-unit are defined by synthetic peptides, Journal of Experimental Medicine, 170, (2), 1989, p383 - 397 Journal Article, 1989 TARA - Full Text

Mills, K.H.G., Nixon, D., McMichael, A., T cell strategies in AIDS vaccine: MHC restricted T-cell responses to HIV proteins, AIDS 13, suppl. 1, 1989, pS101 - S110 Journal Article, 1989

Mills, K.H.G., Recognition of foreign antigen by T cells and their role in immune protection., Cur. Opin. Infect. Dis., 2, (6), 1989, p804 - 814 Journal Article, 1989

Mills, K.H.G., Burt, D.S., Skehel, J.J. and Thomas, D.B, Fine specificity of murine class-II-restricted T cell clones for synthetic peptides of influenza virus haemagglutinin: Heterogeneity of antigen interaction with the T cell and the Ia Molecule, J. Immunol, 140 , 1988, p4083 - 4090 Journal Article, 1988 URL

Mills, K.H.G, Inhibitory effects of monoclonal antibodies to a synthetic peptide of influenza haemagglutinin on the processing and presentation of viral antigens to class II-restricted T cell clones, Immunology, 65, 1988, p365 - 371 Journal Article, 1988 TARA - Full Text URL

In vitro culture of T cell lines and clones in, editor(s)G.B. Klaus , Lymphocytes: A practical approach, Oxford, IRL Press, 1987, pp133 - 147, [Taylor, P.M., Thomas, D.B. and Mills, K.H.G.] Book Chapter, 1987

Thomas, D.B., Skehel, J.J., Mills, K.H.G. and Graham, C.M, A single amino acid substitution in influenza haemagglutinin abrogates recognition by monoclonal antibody and a spectrum of subtype-specific L3T4+ T-cell clones, Eur. J. Immunol, 17, 1987, p133 - 136 Journal Article, 1987

An indirect rosette technique for the identification and separation of lymphocyte subpopulations by monoclonal antibodies in, Immunological techniques, Methods in Enzymology, Florida, USA, Academic Press, 1986, pp726 - 737, [Mills, K.H.G.] Book Chapter, 1986

Thomas, D.B., Skehel, J.J., Mills, K.H.G. and Graham, C.M, Suicide selection of murine T-helper clones specific for defined regions of the influenza haemagglutinin molecule, Eur. J. Immunol, 16, 1986, p789 - 793 Journal Article, 1986 URL

Mills, K.H.G, Processing of viral antigens and presentation to class II-restricted T cells, Immunol. Today , 7, (9), 1986, p260 - 263 Journal Article, 1986 URL DOI

Mills, K.H.G., Skehel, J.J. and Thomas, D.B, Conformational dependent recognition of influenza virus haemagglutinin by murine T-helper clones, Eur. J. Immunol, 16, 1986, p276 - 280 Journal Article, 1986 DOI URL

Mills, K.H.G., Skehel, J.J., Graham, C.M. and Thomas, D.B, Extensive diversity in the recognition of influenza virus haemagglutinin by murine T cell clones, Journal of Experimental Medicine, 163, (6), 1986, p1477 - 1490 Journal Article, 1986 URL

Mills, K.H.G. and Cawley, J.C., Stimulated lymphoid cells of B lineage, but not plasma or myeloid cells can express E receptor., Leuk. Res, 9375-380, (3), 1985, p375 - 380 Journal Article, 1985 URL DOI

Semenzato, G., Herrman, F. and Mills, K.H.G, T cell subpopulations in B cell chronic lymphocytic leukemias, Clin. Exp. Immunol, 57, (3), 1984, p752 - 754 Journal Article, 1984 URL TARA - Full Text

Worman, C.P., Mills, K.H.G. and Cawley, J.C, Non T lymphoid cells can express T cell surface characteristics: normal, HCL and a range of leukaemia B cells express T cell antigens after appropriate in vitro stimulation, Seminars Oncol, 11, 1984, p401 - 404 Journal Article, 1984

Mills, K.H.G., Armitage, R.J. and Worman, C.P, An indirect technique for the identification and separation of human lymphocyte populations by monoclonal antibodies: a comparison with immunofluorescence techniques, Immunol. Letts , 6, 1983, p241 - 246 Journal Article, 1983 DOI URL

Mills, K.H.G., Worman, C.P. and Cawley, J.C, Helper/suppressor T cells in B cell malignancies, Br. J. Haematol, 53, 1983, p271 - 275 Journal Article, 1983

Mills, KHG, Greally JF, Allogeneic bone marrow transplantation in the rat:Effect of cellular content on graft "take" and graft-versus-host disease, Transplant Proceedings, 15, 1983, p1446 - 1450 Journal Article, 1983

Mills, K.H.G., Worman, C.P. and Cawley, J.C, Normal human B cells express endogenous E receptor after appropriate in vitro culture, Eur. J. Immunol, 13, 1983, p379 - 382 Journal Article, 1983 DOI URL

Armitage, R.J., Worman, C.P., Mills, K.H.G. and Cawley, J.C, A B cell proliferation with aberrant E-rosette formation: a sequential study with a panel of monoclonal antibodies and other surface markers, Scand. J. Haematol, 30, (3), 1983, p211 - 217 Journal Article, 1983

Worman, C.P., Mills, K.H.G., Linch, D.C., Beverley, P.C.L., Goldstone, A.H. and Cawley, J.C., Amegokaryocytic thrombocytopenia associated with an excess of Leu 2a+ suppressor cells, Scand. J. Haematol., 28, 1982, p215 - 219 Journal Article, 1982

Mills, K.H.G. and Cawley, J.C., Suppressor T cells in B-cell chronic lymphocytic leukaemia: relationship to clinical stage., Leuk. Res, 6, 1982, p653 - 657 Journal Article, 1982 URL DOI

Mills, K.H.G., Worman, C.P. and Cawley, J.C., T cell subsets in B-chronic lymphocytic leukaemia (CLL)., Br. J. Haematol., 50, 1982, p710 - 712 Journal Article, 1982

Mills, K.H.G, Cawley, J.C., ABNORMAL MONOCLONAL ANTIBODY-DEFINED HELPER-SUPPRESSOR T-CELL SUBPOPULATIONS IN MULTIPLE-MYELOMA - RELATIONSHIP TO TREATMENT AND CLINICAL STAGE , British Journal of Haematology, 53, (2), 1982, p271 - 275 Journal Article, 1982

Mills, K.H.G., Greally, J.F., Temperley, I.J. and Mullins, G.M., Haematological and immune-suppressive effects of total body irradiation in the rat, Ir J. Med. Sci., 149, 1980, p201 - 208 Journal Article, 1980

Bailey, C.J., Jeffroy, P. and Mills, K.H.G., An examination of the distribution of Hen- and Goose-type lysozyme in anseriforms, Comp. Biochem. Physiol., 553, 1977, p429 - 433 Journal Article, 1977

Research Expertise

Description

A major interest of my research is to understand the effector immune responses that protect us against infection and cancer and how, when uncontrolled this can lead to autoimmune diseases. I am particularly interested the factors that affect the induction, of the distinct subpopulations of CD4+ T cells, termed Th1, Th2 and T regulatory (Treg) and Th17 cells, and the role of innate immune system, in particular dendritic cells, in directing T cell responses. The work has direct application to the development of new or improved vaccines and includes studies on Bordetella pertussis, Fasciola hepatica, influenza virus and hepatitis C virus. In the last number of years my group has focused on immune regulation and immune modulation by pathogens. This has been made possible through PI and Strategic research cluster (SRC) awards from Science Foundation Ireland. The aims are to examine the role of pathogen-derived molecules in modulating immune responses, with particular reference to the induction, regulation and function of T cell subtypes and the induction and control of inflammatory responses. Our hypothesis is that the study of immunomodulation by microbial pathogens is an ideal approach to understand mechanisms of protective immunity and immunoregulation in vivo and will allow the identification and characterization of novel immunomodulatory molecules with potential as therapies for immune mediated diseases. We have identified molecules capable of specifically suppressing or enhancing immune response that regulate or mediate certain human diseases. The application of this research is the development of new or improved vaccines against infectious diseases, active immunotherapeutics against cancer and anti-inflammatory therapeutics against autoimmune diseases. A recent SFI PI award on 'the role of regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human disease' is focused on the interface between innate and adaptive immunity, specifically how we can manipulate dendritic cells to selectively alter the balance of regulatory (Treg) versus effector (Th1 or Th2) or pathogenic (Th17). Our aim is to design new approaches to treat autoimmunity by enhancing induction of Treg which suppress Th17 cells and to develop new infectious diseases vaccines and cancer immunotherapeutics by enhancing induction of Th1 and Th2 cells, while inhibiting Treg cells.

Projects

  • Title
    • The local immune response to a respiratory pathogen
  • Summary
    • €38,000
  • Funding Agency
    • Health Research Board project grant
  • Date From
    • 1993
  • Date To
    • 1996
  • Title
    • Investigations on the mechanism of immunity to B. pertussis in a murine model
  • Summary
    • €283,000
  • Funding Agency
    • Wellcome Trust project grant
  • Date From
    • 1994
  • Date To
    • 1997
  • Title
    • Programme EVA "Vaccine Delivery systems for the selective induction of cellular immune responses with candidate HIV vaccines
  • Summary
    • €38,000
  • Funding Agency
    • EU Biomed-1
  • Date From
    • 1994
  • Date To
    • 1996
  • Title
    • T cell responses to Bordetella pertussis in children and the development of an acellular pertussis vaccine
  • Summary
    • €38,000
  • Funding Agency
    • The Health Research Board project grant
  • Date From
    • 1994
  • Date To
    • 1997
  • Title
    • Cellular immune responses to HIV
  • Summary
    • Support for Postdoctoral fellow plus €13,000 for consumables costs
  • Funding Agency
    • Commonwealth AIDS Research Grants
  • Date From
    • 1994
  • Date To
    • 1995
  • Title
    • The use of controlled release microparticles as oral and parenteral vaccines against Vibrio cholera, E. coli and Bordetella pertussis
  • Summary
    • €15,400
  • Funding Agency
    • EU STD Programme
  • Date From
    • 1995
  • Date To
    • 1997
  • Title
    • Investigations of the biochemical basis for the immunomodulatory properties of pertussis toxin
  • Summary
    • €25,000,
  • Funding Agency
    • Forbairt Basic Research Grant
  • Date From
    • 1995
  • Date To
    • 1997
  • Title
    • Mucosal vaccines for respiratory diseases based upon nasal administration
  • Summary
    • €239,000, 1996-2000.
  • Funding Agency
    • EU Innovation Programme
  • Date From
    • 1996
  • Date To
    • 2000
  • Title
    • The role of T cell-derived cytokines in vaccine induced immunity against whooping cough in infants
  • Summary
    • €44,000
  • Funding Agency
    • National Institute for Health (NIH), USA
  • Date From
    • 1996
  • Date To
    • 1997
  • Title
    • Evaluation of biodegradable microparticles as a vaccine delivery system for an acellular pertussis vaccine
  • Summary
    • €305,000
  • Funding Agency
    • Forbairt Applied Research Award and Elan Corporation
  • Date From
    • 1997
  • Date To
    • 2001
  • Title
    • Genetic and immunological safety of nucleic acid vaccines
  • Summary
    • €220,000,
  • Funding Agency
    • EU Biotechnology Programme
  • Date From
    • 1997
  • Date To
    • 2000
  • Title
    • Virus variants and host immune response in the resolution and progression of chronic liver disease following Hepatitis C virus infection
  • Summary
    • €890,000
  • Funding Agency
    • Health Research Board Unit with D. Kelleher, C. O'Farrelly, W. Hall, J, Hegarty
  • Date From
    • 1997
  • Date To
    • 2002
  • Title
    • Chiron Corporation Fellowship 'Mechanism of adjuvant activity of E
  • Summary
    • €68,000
  • Funding Agency
    • coli heat labile toxin
  • Date From
    • 1996
  • Date To
    • 1999
  • Title
    • Mechanism of adjuvant activity of E. coli heat labile toxin
  • Summary
    • €68,000
  • Funding Agency
    • Chiron Corporation Fellowship
  • Date From
    • 1996
  • Date To
    • 1999
  • Title
    • HIV nucleic acid vaccination: targeting of antigen presenting cells and induction of specific mucosal immune responses'
  • Summary
    • €85,000
  • Funding Agency
    • EU Biomed Programme
  • Date From
    • 1997
  • Date To
    • 2000
  • Title
    • Neuroimmunological interactions in response to infection with a Gram negative bacterium
  • Summary
    • €95,000
  • Funding Agency
    • Forbairt Basic Research Grant
  • Date From
    • 1997
  • Date To
    • 2000
  • Title
    • Purchase of an irradiator for inhibition of cell proliferation, induction of apoptosis and gene mutations and conditioning recipients in murine adoptive transfer experiments
  • Summary
    • €100,000
  • Funding Agency
    • Wellcome Trust Equipment award S. Martin, co-applicant
  • Date To
    • 1997
  • Title
    • Interdependence of immune mechanisms in protection against Bordetella pertussis
  • Summary
    • €215,000
  • Funding Agency
    • Wellcome Trust project grant
  • Date From
    • 1997
  • Date To
    • 2001
  • Title
    • Acquisition of an automated DNA sequencer and gel documentation system for investigations on the mechanisms of programmed cell death and immunity to infectious diseases
  • Summary
    • €75,500
  • Funding Agency
    • Wellcome Trust/HRB equipment award with S. Martin
  • Date To
    • 1997
  • Title
    • Regulation and effector function of Th1 and Th2 cells in immunity to a respiratory pathogen'
  • Summary
    • €38,000
  • Funding Agency
    • The Health Research Board Project Grant
  • Date From
    • 1997
  • Date To
    • 2000
  • Title
    • Biosafety of vaccines based on self-replicating recombinant alphavirus'
  • Summary
    • €123, 000
  • Funding Agency
    • EU Biotechnology Programme
  • Date From
    • 1998
  • Date To
    • 2000
  • Title
    • The role of cathepsin L cysteine proteinases secreted by helminth pathogns in modulation of immune responses
  • Summary
    • €76,000
  • Funding Agency
    • Health Research Board Postdoctoral Fellowship
  • Date From
    • 1999
  • Date To
    • 2000
  • Title
    • Demonstration and Shared cost projects Mucosal Vaccines - mucosal adjuvanticity of LT mutants with influenza virus antigens for intranasal immunization
  • Summary
    • €200,000
  • Funding Agency
    • EU Framework 5 Biotechnology Programme
  • Date From
    • 2000
  • Date To
    • 2003
  • Title
    • Modulation of immune responses by filamentous haemagglutinin from Bordetella pertussis
  • Summary
    • €89,000
  • Funding Agency
    • Health Research Board project grant
  • Date From
    • 2000
  • Date To
    • 2003
  • Title
    • Role of toxin induced interlukin-1b in the neurological responses to gram negative bacteria'
  • Summary
    • €89,000
  • Funding Agency
    • Enterprise Ireland Basic research grant
  • Date From
    • 2000
  • Date To
    • 2004
  • Title
    • Programme for Research in Third level Institutions in Ireland
  • Summary
    • €11.3million award to the NUI Maynooth, including €1m current costs for Immunology Research,
  • Funding Agency
    • Higher Education Authority
  • Date From
    • 1999
  • Date To
    • 2001
  • Title
    • Activation of innate responses by immunostimulatory sequences in bacterial DNA
  • Summary
    • €155,500
  • Funding Agency
    • Elan Corporation Student Fellowship
  • Date From
    • 2000
  • Date To
    • 2003
  • Title
    • Nasal vaccination - a balance between beneficial immunity and neurotoxicity'
  • Summary
    • €152,000,
  • Funding Agency
    • Health Research Board Project grant
  • Date From
    • 2001
  • Date To
    • 2004
  • Title
    • Regulatory T cell induction - an immune subversion strategy by Bordetella pertussis'
  • Summary
    • €149,000
  • Funding Agency
    • Health Research Board Postdoctoral Fellowship to Dr Peter Mc Guirk
  • Date From
    • 2001
  • Date To
    • 2004
  • Title
    • Pathogen-derived immunomodulatory molecules - future therapeutics and vaccines
  • Summary
    • €6.5m
  • Funding Agency
    • Science Foundation Ireland Principal Investigator Award
  • Date From
    • 2001
  • Date To
    • 2006
  • Title
    • The role of regulatory T cells in parasite immunosuppression'
  • Summary
    • €163,021
  • Funding Agency
    • Health Research Board Postdoctoral fellowship to Dr Miriam Brady
  • Date From
    • 2002
  • Date To
    • 2005
  • Title
    • Modulation of host immune responses by effector proteins of he type III secretion system of Bordetella pertussis
  • Summary
    • €163,352
  • Funding Agency
    • IRSCET Basic Research Project
  • Date From
    • 2002
  • Date To
    • 2005
  • Title
    • With Prof Cliona O'Farrelly, St Vincent's Hospital (PI), Dr Dermot Kelleher, Trinity College Dublin and Dr Derek Doherty, NUI Maynooth. Characterisation of hepatitis C virus induced immunological subversion and its implications for treatment response
  • Summary
    • €552,000
  • Funding Agency
    • Health Research Board Programme Grant
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • Mucosal Vaccines for Poverty Related Diseases (MUVAPRED). FP6-2002-LIFESCIHEALTH-2.3, Proposal No 503240
  • Summary
    • €15m approx €350,000 to TCD
  • Funding Agency
    • EU 6th Framework Programme
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • Pre-clinical evaluation of immunomodulatory molecules in the prevention or treatment of immune-mediated diseases
  • Summary
    • €379,646
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2004
  • Date To
    • 2007
  • Title
    • Purchase of a high speed cell sorter
  • Summary
    • €387,200.
  • Funding Agency
    • SFI
  • Date From
    • 2004
  • Title
    • Regulation of T cell responses in immunity to Bordetella pertussis
  • Summary
    • €209491
  • Funding Agency
    • HRB
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • The evaluation of immunomodulators in ex-vivo models of cell based therapies and in the enhancement of efficacy of marketed biologicals
  • Summary
    • €372,704
  • Funding Agency
    • EI
  • Date From
    • 2005
  • Date To
    • 2007
  • Title
    • Regulatory T cell control of pathogenic and effector T cells and their manipulation as potential therapies for human diseases
  • Summary
    • €3.6m
  • Funding Agency
    • SFI
  • Date From
    • 2007
  • Date To
    • 2112
  • Title
    • Nasal Pandemic Influenza Vaccine (NASPANVAC)
  • Summary
    • €4.07m; €488,016 to TCD
  • Funding Agency
    • EU
  • Date From
    • 1st May 2008
  • Date To
    • April 2011
  • Title
    • Immunology Research Centre
  • Summary
    • €7.5m
  • Funding Agency
    • SFI
  • Date From
    • 2008
  • Date To
    • 2013
  • Title
    • The role of NOD-like receptors in inflammatory responses
  • Summary
    • IRCSET Enterprise Partnership Scheme Postgraduate Scholarship Award to Patrick Kelly, Co-funded by Industrial sponsor Opsona Therapeutic
  • Funding Agency
    • IRCSET Enterprise Partnership Scheme
  • Date From
    • 1.10.09
  • Date To
    • 30.9.12
  • Title
    • IA study of exogenous and endogenous factors that precipitate, exacerbate or regulate the T cells that cause autoimmune diseases
  • Funding Agency
    • IRSCET
  • Date From
    • 1.10.2009
  • Date To
    • 30.9.2011
  • Title
    • Activation and role of γδ T cells in mucosal immunity
  • Funding Agency
    • HRB
  • Date From
    • 10/2010
  • Date To
    • 9/2013
  • Title
    • The role of infections agents in precipitating the neurodegenerative changes that lead to development of Alzheimer's disease.
  • Funding Agency
    • TCD-UCD Innovation Alliance (joint project with Marina Lynch)
  • Date From
    • 2010
  • Date To
    • 2014
  • Title
    • Regulatory T cell inducing vaccine for autoimmune diseases.
  • Funding Agency
    • HRB
  • Date From
    • 2011
  • Date To
    • 2014
  • Title
    • New immunotherapeutics approaches based on the Th1/Th17 axis and its regulation.
  • Funding Agency
    • SFI
  • Date From
    • 2012
  • Date To
    • 2017
  • Title
    • Function and regulation IL-17-secreting T cells
  • Funding Agency
    • PRTLI
  • Date From
    • 2012
  • Date To
    • 2015
  • Title
    • Flow Cytometry Cell Sorter, €587,000.
  • Funding Agency
    • SFI
  • Date From
    • 2013
  • Date To
    • 2015
  • Title
    • Helminth-derived immunomodulatory molecules as therapeutics for immune-mediated disease
  • Funding Agency
    • SFI
  • Date From
    • 2014
  • Date To
    • 2015
  • Title
    • The effect of retinoic acid on the fate of γδ T cells.
  • Funding Agency
    • EU-FP7
  • Date From
    • 2014
  • Date To
    • 2016

Keywords

ACELLULAR PERTUSSIS-VACCINE; ACTIVATION PATHWAY; ANTIGEN; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis); BACTERIAL; BACTERIAL INFECTION; BACTERIAL LIPOPOLYSACCHARIDE; BACTERIAL TOXINS; BIODEGRADABLE MICROPARTICLE; BLOOD MONONUCLEAR-CELLS; BORDETELLA PERTUSSIS; CD4+ T CELLS; CELL-MEDIATED-IMMUNITY; CHOLERA-TOXIN; CYTOKINE PRODUCTION; CYTOKINES; DEMYELINATION; ENDOTOXIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FILAMENTOUS HEMAGGLUTININ; GROWTH-FACTOR-BETA; HOST-DEFENSE; HUMAN DENDRITIC CELLS; HUMAN-IMMUNODEFICIENCY-VIRUS; IL-1; IL-1 RECEPTOR; IL-1/MAP KINASES; IL-10; IL-12; IL-4; IMMUNE-RESPONSES; IMMUNOSUPPRESSION; Immunotherapies for Cancer; Infectious Diseases; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-1; INTERLEUKIN-1 BETA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; INTERLEUKIN-1 RECEPTORS; INTERLEUKIN-1-BETA; INTERLEUKIN-1-BETA MESSENGER-RNA; INTERLEUKIN-2; LEUKOCYTE ADHESION MOLECULES; LIPOPOLYSACCHARIDE; MACROPHAGES; MAP KINASE; MONOCLONAL-ANTIBODIES; MONOCYTE; MULTIPLE-SCLEROSIS; MURINE MACROPHAGES; MYELIN BASIC-PROTEIN; NF-KAPPA-B; NITRIC-OXIDE; PHOSPHORYLATION; PROTEINS; SEIZURE; SIGNAL-TRANSDUCTION; SIGNAL-TRANSDUCTION PATHWAYS; SURFACE PROTEIN; T LYMPHOCYTES; T-CELL ACTIVATION; T-CELLS; T-LYMPHOCYTE ACTIVATION; TH1 CELL; TH1 CELLS; TRANSCRIPTION FACTOR; VACCINATION; Vaccines; VIRAL-INFECTIONS

Recognition

Representations

Member, Irish Branch Committee of the Society for General Microbiology. 1994-1997

Member, Immunology & Pathology Committee of the Health Research Board. 1994-2000

Irish representative at the International Union of Immunological Societies and the European Federation of Immunology Societies. 1994-1998

Member, Expert Committee on Blood Products and Vaccines of Irish Medicines Board. 1996-2001

Member, WHO International Committee on DNA Vaccines. 1996-2000

Member, Life Sciences / Biotechnology Panel, Enterprise Ireland Strategic and Basic Research Grant schemes. 1996-2002

Member, National Committee for Biochemistry of the Royal Irish Academy. 1997-2001

Member, Editorial Board of European Federation of Microbiology Societies, Immunology and Medical Microbiology. 1998-2013

Member, Infection & Immunity Committee of British Society for Immunology. 1998-present

Member, World Health Organization Working Group on Pertussis Vaccines. 1998-2000

Member of Microbiology and Mechanisms of Infectious Disease and Host Defence Committee of the Health Research Board. 2001-

Member expert committee on Medical Devices, Irish Medicines Board. 2001-

Member of Board of Management of the Adelaide Hospital of The Adelaide, Meath and National Children's Hospital, Tallaght, Dublin. 2002-

Member of Scientific Advisory Committee of Science Foundation Ireland. 2002-2003

Chairman of Infection & Immunity Group of the British Society for Immunology. 2002-

Chair an Expert Group established by the Minister for Health and Children to examine processes to ensure continuing quality of vaccine products. 2003

Member of Life Science Committee of Royal Irish Academy. 2003-2004

Panel Chairman, Science Foundation Ireland Basic Research Grants. 2004

Member of the Wellcome Trust Immunology and Infectious Disease Committee 2003-2006

Member of the Editorial Board of Clinical and Experimental Immunology 2005-2013

Associate Editor. The Journal of Immunology 2007-2011

Section Editor, The Journal of Immunology 2012-present

Member of the Editorial Board. Immunology and Cell Biology 2013-

Awards and Honours

Royal Academy of Medicine in Ireland Doctor award in Respiratory Medicine and best overall paper 2014

Laboratory Scientist of the year and Laboratory of the year, Irish Lab awards 2013

Elected to Fellowship of Trinity College Dublin 2004

Royal Irish Academy Award in Biochemistry 2004

Inaugural Annual Award of Irish Society for Immunology 2002

Awarded Graves Medal and present the 39th Annual Graves Lecture 1999

Elected to membership of the Institute of Biology of Ireland 1996

Elected Fellow of The Royal Academy of Medicine in Ireland 1994

Elected to fellowship of The Royal Academy of Medicine in Ireland 1994

Merit award of rapid promotion to Senior Scientist scale 1991

Young scientist award from International Union of Immunology Societies 1986

Awarded fellowship by International Network of Immunology 1987

Awarded EURATOM travelling fellowship 1977

Elected Student of the year, Wilson's Hospital, Secondary School 1972

Memberships

American Association of Immunologists 2006-

American Society for Microbiology

International Society for Mucosal Immunology

British Society for Immunology

British and Irish Society for General Microbiology

Biochemical Society

Irish Research Scientists Association

Irish Society for Immunology

Royal Academy of Medicine in Ireland

Institute of Biology of Ireland

Member, UK MRC Committee on Vaccines & Immunization Procedures 1991 – 1995

Member, Irish Branch Committee of the Society for General Microbiology 1994 – 1997

Member, Irish Area Committee of The Biochemical Society. 1998 – 2001