Biography
Claire Healy is a Research Fellow who joined the lab of Dr Suzanne Cloonan in May 2020. Claire completed her undergraduate studies at Trinity College Dublin (Microbiology). She obtained her PhD (2014) from University College Dublin, Ireland where she worked in the lab of Prof Stephen Gordon. From 2014 to 2020 Claire carried out her postdoctoral training at Weill Cornell Medicine (NYC, USA) in the lab Prof Sabine Ehrt. Her research has focused on molecular mechanisms of pathogenesis in Mycobacterium tuberculosis, the causative agent of tuberculosis, an infectious disease which primarily affects the lungs. Her primary research focus in the Cloonan lab is to investigate host-pathogen interactions in opportunistic non-tuberculous mycobacteria (NTM) lung infections in COPD.
Publications and Further Research Outputs
Peer-Reviewed Publications
Alexandre Gouzy, Claire Healy, Dirk Schnappinger, Sabine Ehrt, Reliable detection of pyrazinamide antitubercular activity in vitro, 2022
Hongwei Su, Kan Lin, Divya Tiwari, Claire Healy, Carolina Trujillo, Yao Liu, Thomas R. Ioerger, Dirk Schnappinger, Sabine Ehrt, Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity, Journal of Experimental Medicine, 218, (9), 2021
Healy, C. and Munoz-Wolf, N. and Strydom, J. and Faherty, L. and Williams, N.C. and Kenny, S. and Donnelly, S.C. and Cloonan, S.M., Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease, Respiratory Research, 22, (1), 2021
Gouzy A., Healy C., Black K, Rhee, K. Y, Ehrt S., Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity, Growth of Mycobacterium tuberculosis at acidic pH depends on lipid assimilation and is accompanied by reduced GAPDH activity, 118, (32), 2021
Healy, C., Gouzy, A., Ehrt, S., Peptidoglycan hydrolases RipA and Ami1 are critical for replication and persistence of Mycobacterium tuberculosis in the host, mBio, 11, (2), 2020
, Chemical genetic interaction profiling reveals determinants of intrinsic antibiotic resistance in Mycobacterium tuberculosis, Antimicrobial agents and chemotherapy, 2017
Healy, Claire, The MarR family transcription factor Rv1404 coordinates adaptation of Mycobacterium tuberculosis to acid stress via controlled expression of Rv1405c, a virulence-associated methyltransferase, Tuberculosis, 2016
, RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli, Scientific reports, 2015
, Innate cytokine profiling of bovine alveolar macrophages reveals commonalities and divergence in the response to Mycobacterium bovis and Mycobacterium tuberculosis infection, Tuberculosis, 2014
Sharkey, M.A., O'Gara, J.P., Gordon, S.V., Hackenberg, F., Healy, C., Paradisi, F., Patil, S., Schaible, B., Tacke, M., Investigations into the antibacterial activity of the silver-based antibiotic drug candidate SBC3, Antibiotics, 1, 2012, p25-28
Research Expertise
Recognition
Awards and Honours
Dean's Research Initiatives Award 2022
Memberships
Microbiology Society, Member
American Society of Microbiology, Member
European Respiratory Society, Member