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Trinity College Dublin, The University of Dublin

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Professor Gregory Atkins
Fellow Emeritus, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Atkins, G.J. and Sheahan, B.J., Molecular determinants of alphavirus neuropathogenesis in mice, Journal of General Virology, 97, (6), 2016, p1283-1296 Journal Article, 2016 DOI

Roche, F.P., Sheahan, B.J., O'Mara, S.M., Atkins, G.J., Semliki Forest virus-mediated gene therapy of the RG2 rat glioma, Neuropathology and Applied Neurobiology, 36, (7), 2010, p648-660 Journal Article, 2010 DOI

Piggott, J.M., Sheahan, B.J., Soden, D.M., O'Sullivan, G.C., Atkins, G.J., Electroporation of RNA stimulates immunity to an encoded reporter gene in mice , Molecular Medicine Reports, 2, (5), 2009, p753-756 Journal Article, 2009 DOI

Atkins GJ, Fleeton MN, Sheahan, BJ. , Therapeutic and prophylactic applications of alphavirus vectors., Expert Reviews in Molecular Medicine., 10, 2008, pe33 Journal Article, 2008 DOI

Quinn,K, Galbraith, SE, Sheahan, BJ, Atkins, GJ., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing interferon-ß on the progression of experimental autoimmune encephalomyelitis., Molecular Medicine Reports., 1, (3), 2008, p335 - 342 Journal Article, 2008 URL TARA - Full Text

Logue CH, Sheahan BJ, Atkins GJ, The 5' untranslated region as a pathogenicity determinant of Semliki Forest virus in mice., Virus genes, 36, (2), 2008, p313-21 Journal Article, 2008 DOI

Callagy S.J., Kelly B.J., Fleeton M.N., Sheahan B.J., Galbraith S.E., and Atkins, G. J., Semliki Forest virus vectors expressing the H and HN genes of measles and mumps viruses reduce immunity induced by the envelope protein genes of rubella virus., Vaccine, 25, (43), 2007, p7481 - 7490 Journal Article, 2007 DOI

Galbraith, S.E., Atkins, G. J., Sheahan, B. J., A Semliki Forest virus replication competent vector with enhanced biosafety., 2007, WO2007/102140 Patent, 2007

J A Lyons, B J Sheahan, S E Galbraith, R Mehra, G J Atkins and M N Fleeton, Inhibition of angiogenesis by a Semliki Forest virus vector expressing VEGFR-2 reduces tumour growth and metastasis in mice, Gene Therapy, 14, 2007, p503 - 513 Journal Article, 2007 DOI URL

Kelly BJ, Fleeton MN, Atkins GJ., Potential of Alphavirus Vectors in the Treatment of Advanced Solid Tumors, Recent patents on anti-cancer drug discovery, 2, 2007, p159-166 Review, 2007

Galbraith SE, Sheahan BJ, Atkins GJ, Deletions in the hypervariable domain of the nsP3 gene attenuate Semliki Forest virus virulence, JOURNAL OF GENERAL VIROLOGY, 87, (Part 4), 2006, p937 - 947 Journal Article, 2006 URL DOI

Mabruk MJ, Sheahan BJ, Atkins GJ. , The effect of infection of hatched blastocyst bovine embryos with border disease and bovine viral diarrhea viruses, Southeast Asian Journal of Tropical Medicine and Public Health, 37, 2006, p113 - 119 Journal Article, 2006

Chikkanna-Gowda CP, McNally S, Sheahan BJ, Fleeton MN, Atkins GJ, Inhibition of murine K-BALB and CT26 tumour growth using a Semliki Forest virus vector with enhanced expression of IL-18, Oncology Reports, 16, 2006, p713 - 719 Journal Article, 2006 URL

CP Chikkanna-Gowda, BJ Sheahan, MN Fleeton and GJ Atkins, Regression of mouse tumours and inhibition of metastases following administration of a Semliki Forest virus vector with enhanced expression of IL-12, Gene Therapy, 12, (16), 2005, p1253 - 1263 Journal Article, 2005 DOI URL

Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM. , The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo., Oncology Reports, 14, 2005, p1357 - 1363 Journal Article, 2005 URL

Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363 Journal Article, 2005

J.W.P. Smyth, M.N. Fleeton, B.J. Sheahan, G. J. Atkins , Treatment of rapidly growing K-BALB and CT26 mouse tumours using Semliki Forest virus and its derived vector , Gene Therapy, 12, (2), 2005, p147 - 159 Journal Article, 2005 DOI URL

G.J. Atkins, M.N. Fleeton, J. W. P. Smyth, B. J. Sheahan, Alphaviruses and their derived vectors as anti-tumor agents, Current Cancer Drug Targets, 4, (7), 2004, p597 - 607 Journal Article, 2004 URL

Fleeton MN, Gowda CPC, Atkins GJ, Antiangiogenic tumour therapy using Semliki forest virus vectors encoding IL-12, JOURNAL OF GENE MEDICINE, 6, (9), 2004, pS31 - S31 Journal Article, 2004

Keogh, B., Atkins, G.J., Sheahan, B.J. and Mills, K.H.G., Inhibition of metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent semliki forest virus infection, Vet. Immunol. Immunopathol., 94, (3-4), 2003, p185 - 190 Journal Article, 2003 URL DOI

Atkins, G. J. and Cosby, S. L, Is an improved measles-mumps-rubella vaccine necessary or feasible?, Critical Reviews in Immunology , 23, (4), 2003, p323 - 338 Journal Article, 2003 DOI URL

Jerusalmi, A., Morris-Downes, M. M., Sheahan, B. J. and Atkins, G. J., Effect of intranasal administration of Semliki Forest virus recombinant particles expressing reporter and cytokine genes on the progression of experimental autoimmune encephalomyelitis., Molecular Therapy, 8, (6), 2003, p886 - 894 Journal Article, 2003 URL URL

Keogh, B., Atkins, G.J., Mills, K.H.G. and Sheahan, B.J., Role of interferon-gamma and nitric oxide in the neuropathogenesis of avirulent semliki forest virus infection Neuropathol, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562 Journal Article, 2003 URL DOI

Keogh, B., Sheahan, B. J., Atkins, G. J. and Mills, K. H. G., Inhibition of matrix metalloproteinases ameliorates blood-brain barrier disruption and neuropathological lesions caused by avirulent Semliki Forest virus infection., Veterinary Immunology and Immunopathology, 94, (3-4), 2003, p185 - 190 Journal Article, 2003 DOI URL

Keogh, B., Atkins, G. J., Mills, K. H. G. and Sheahan, B. J., Role of interferon- × and nitric oxide in the neuropathogenesis of avirulent Semliki Forest virus infection, Neuropathology and Applied Neurobiology , 29, (6), 2003, p553 - 562 Journal Article, 2003 URL DOI

Atkins, G. J., Mooris-Downes, M. M., Jerusalmi, A. and Sheahan, B. J. , An expression vector for the central nervous system, 2003, PCT/IE03/00089 Patent, 2003

KEOGH, B, AVIRULENT SEMLIKI FOREST VIRUS REPLICATION AND PATHOLOGY IN THE CENTRAL NERVOUS SYSTEM IS ENHANCED IN IL-12-DEFECTIVE AND REDUCED IN IL-4-DEFECTIVE MICE: A ROLE FOR TH1 CELLS IN THE PROTECTIVE IMMUNITY, JOURNAL OF NEUROIMMUNOLOGY, 125, 2002, p15 - 22 Journal Article, 2002 DOI URL

Keogh, B., Atkins, G.J., Mills, K.H.G., Sheahan, B.J, Avirulent Semliki Forest virus replication and pathology in the central nervous system is enhanced in IL-12-defective and reduced in IL-4-defective mice: A role for Th1 cells in the protective immunity , Journal of Neuroimmunology , 125, 2002, p15 - 22 Journal Article, 2002 DOI

DOMEGAN, LM, ATKINS, GJ., APOPTOSIS INDUCTION BY THE THERIEN AND VACCINE RA27/3 STRAINS OF RUBELLA VIRUS CAUSES DEPLETION OF OLIGODENDROCYTES FROM RAT NEURAL CELL CULTURES, JOURNAL OF GENERAL VIROLOGY, 83, 2002, p2135 - 2143 Journal Article, 2002 URL

Sheahan, B.J., Moore, M., Atkins, G.J., The pathogenicity of louping Ill virus for mice and lambs , Journal of Comparative Pathology , 126, 2002, p137 - 146 Journal Article, 2002 DOI URL

Atkins, G. J., 5th Gene Delivery & Cellular Protein Expression Conference, Vienna, 2001 Invited Talk, 2001

O'Connor, D. P., Kay, E. W., Leader, M., Murphy, G. M., Atkins, G. J. & Mabruk, M. J. E. M. F., A high degree of chromosomal instability at 13q14 in cutaneous squamous cell carcinomas: indication for a role of a tumour, Molecular Pathology , 54, 2001, p165 - 169 Journal Article, 2001 URL

MURPHY, AM, INDUCTION OF APOPTOSIS IN BCL-2-EXPRESSING RAT PROSTATE CANCER CELLS USING THE SEMLIKI FOREST VIRUS VECTOR, INTERNATIONAL JOURNAL OF CANCER, 94, 2001, p572 - 578 Journal Article, 2001 URL DOI

OCONNOR, DP, ALTERED P53 EXPRESSION IN BENIGN AND MALIGNANT SKIN LESIONS FROM RENAL TRANSPLANT RECIPIENTS AND IMMUNOCOMPETENT PATIENTS WITH SKIN CANCER: CORRELATION WITH HUMAN PAPILLOMAVIRUSES?, DIAGNOSTIC MOLECULAR PATHOLOGY, 10, 2001, p190 - 199 Journal Article, 2001 URL

MORRIS-DOWNES, MM, SEMLIKI FOREST VIRUS-BASED VACCINES: PERSISTENCE, DISTRIBUTION AND PATHOLOGICAL ANALYSIS IN TWO ANIMAL SYSTEMS, VACCINE, 19, 2001, p1978 - 1988 Journal Article, 2001 DOI URL

OCONNOR, DP, A HIGH DEGREE OF CHROMOSOMAL INSTABILITY AT 13Q14 IN CUTANEOUS SQUAMOUS CELL CARCINOMAS: INDICATION FOR A ROLE OF A TUMOUR SUPPRESSOR GENE OTHER THAN RB, JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 54, 2001, p165 - 169 Journal Article, 2001 URL

Atkins, G. J., European Committee for Research and Treatment in Multiple Sclerosis 17th symposium , 2001 Invited Talk, 2001

FLEETON, MN, SELF-REPLICATIVE RNA VACCINES ELICIT PROTECTION AGAINST INFLUENZA A VIRUS, RESPIRATORY SYNCYTIAL VIRUS, AND A TICKBORNE ENCEPHALITIS VIRUS, JOURNAL OF INFECTIOUS DISEASES, 183, 2001, p1395 - 1398 Journal Article, 2001 URL

OCONNOR, DP, P53 CODON 72 POLYMORPHISM AND HUMAN PAPILLOMAVIRUS ASSOCIATED SKIN CANCER, JOURNAL OF CLINICAL PATHOLOGY, 54, 2001, p539 - 542 Journal Article, 2001 URL TARA - Full Text DOI

MORRIS-DOWNES, MM, A RECOMBINANT SEMLIKI FOREST VIRUS PARTICLE VACCINE ENCODING THE PRME AND NSL PROTEINS OF LOUPING ILL VIRUS IS EFFECTIVE IN A SHEEP CHALLENGE MODEL, VACCINE, 19, 2001, p3877 - 3884 Journal Article, 2001 DOI URL

MCKENNA, BM, FORMATION OF INFECTIOUS PANCREATIC NECROSIS VIRUS-LIKE PARTICLES FOLLOWING EXPRESSION OF SEGMENT A BY RECOMBINANT SEMLIKI FOREST VIRUS, MARINE BIOTECHNOLOGY, 3, 2001, p103 - 110 Journal Article, 2001 URL DOI

MABRUK, MJEMF, A SIMPLE AND RAPID TECHNIQUE FOR THE DETECTION OF EPSTEIN-BARR VIRUS DNA IN HIV-ASSOCIATED ORAL HAIRY LEUKOPLAKIA BIOPSIES, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 29, 2000, p118 - 122 Journal Article, 2000 DOI URL

MURPHY, AM, INHIBITION OF HUMAN LUNG CARCINOMA CELL GROWTH BY APOPTOSIS INDUCTION USING SEMLIKI FOREST VIRUS RECOMBINANT PARTICLES, GENE THERAPY, 7, 2000, p1477 - 1482 Journal Article, 2000 URL

FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES EXPRESSING LOUPING ILL VIRUS ANTIGENS INDUCE A BETTER PROTECTIVE RESPONSE THAN PLASMID-BASED DNA VACCINES OR AN INACTIVATED WHOLE PARTICLE VACCINE, JOURNAL OF GENERAL VIROLOGY, 81, 2000, p749 - 758 Journal Article, 2000 URL

Atkins, G. J., Mc Quaid, S., Morris-Downes, M. M., Galbraith, S. E., Amor, S., Cosby, S. L. and Sheahan, B. J. , TRANSIENT VIRUS INFECTION AND MULTIPLE SCLEROSIS, REVIEWS IN MEDICAL VIROLOGY, 10, 2000, p291-303 Review, 2000 DOI URL

Phenix, K. V., McKenna, B., Fitzpatrick, R., Vaughan, L., Atkins, G., Liljeström, P. & Todd, D., Cell culture evaluation of the Semliki Forest virus expression system as a novel approach for antigen delivery and expression in fish, Marine Biotechnology , 2, 2000, p27 - 37 Journal Article, 2000 URL DOI

Atkins, G. J., Techniques for gene manipulation, targeting and delivery in the nervous system , EU/FEBS course: , 2000 Invited Talk, 2000

SAMMIN, DJ, CELL DEATH MECHANISMS IN THE OLFACTORY BULB OF RATS INFECTED INTRANASALLY WITH SEMLIKI FOREST VIRUS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 25, 1999, p236 - 243 Journal Article, 1999 DOI URL

FLEETON, MN, RECOMBINANT SEMLIKI FOREST VIRUS PARTICLES ENCODING THE PRME OR NS1 PROTEINS OF LOUPING ILL VIRUS PROTECT MICE FROM LETHAL CHALLENGE, JOURNAL OF GENERAL VIROLOGY, 80, 1999, p1189 - 1198 Journal Article, 1999 URL

Atkins, G. J. , Sheahan, B. J. and Liljeström, P., The molecular pathogenesis of Semliki Forest virus: a model virus made useful?, Journal of General Virology, 80, 1999, p2287-2297 Review, 1999 URL

Atkins, G. J., Society for General Microbiology symposium, 1998 Invited Talk, 1998

Molecular approaches to fish vaccine design in, editor(s)A. Barnes, G. Davidson, M. Hiney and D. McIntosh , Methodology in Fish Disease Research, Aberdeen, Scotland., Albion Press, 1998, pp161 - 166, [Vaughan, L.M., Fitzpatrick, R.M., McKenna B. and Atkins, G. J. ] Book Chapter, 1998

Vaccination with recombinant suicidal DNA/RNA in, editor(s)O. Merten, P. Perrin & B. Griffithspp , New Developments and New Applications in Animal Cell Technology, Dordrecht., Kluwer Academic Publishers, 1998, pp583 - 590, [Berglund, P., Fleeton, M., Smerdou, C., Tubulekas, I., Sheahan, B. J., Atkins, G. J. & Liljeström, P] Book Chapter, 1998 DOI URL

GLASGOW, GM, THE SEMLIKI FOREST VIRUS VECTOR INDUCES P53-INDEPENDENT APOPTOSIS, JOURNAL OF GENERAL VIROLOGY, 79, 1998, p2405 - 2410 Journal Article, 1998 URL

GLASGOW, GM, DEATH MECHANISMS IN CULTURED CELLS INFECTED BY SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1559 - 1563 Journal Article, 1997 URL

SAMMIN, DJ, SHEAHAN, BJ, ATKINS, GJ, MECHANISMS OF CELL DEATH IN THE CNS OF WEANLING RATS INFECTED WITH SEMLIKI FOREST VIRUS, IRISH VETERINARY JOURNAL, 50, 1997, p365 - 365 Journal Article, 1997

TARBATT, CJ, SEQUENCE ANALYSIS OF THE AVIRULENT, DEMYELINATING A7 STRAIN OF SEMLIKI FOREST VIRUS, JOURNAL OF GENERAL VIROLOGY, 78, 1997, p1551 - 1557 Journal Article, 1997 URL

Caffrey, J. F., Dudgeon, A. M., Donnelly, W. J. C., Atkins, G. J. and Sheahan, B. J. , Morphometric analysis of growth retardation in foetal lambs following experimental infection of pregnant ewes with border disease virus, Research in Veterinary Science , 62, 1997, p245 - 248 Journal Article, 1997 DOI URL

DONNELLY, SM, LONG-TERM EFFECTS OF SEMLIKI FOREST VIRUS INFECTION IN THE MOUSE CENTRAL NERVOUS SYSTEM, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 23, 1997, p235 - 241 Journal Article, 1997 URL DOI

MABRUK, MJEMF, A RAPID MICROWAVE-IN SITU HYBRIDIZATION METHOD FOR THE DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA: COMPARISON WITH IMMUNOHISTOCHEMISTRY, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 25, 1996, p170 - 176 Journal Article, 1996 URL DOI

BALLUZ, IM, FARRELL, MA, KAY, E, STAUNTON, MJ, KEATING, JN, SHEILS, O, COSBY, SL, MABRUK, MJEMF, SHEAHAN, BJ, ATKINS, GJ, COLOCALISATION OF HUMAN IMMUNODEFICIENCY VIRUS AND HUMAN CYTOMEGALOVIRUS INFECTION IN BRAIN AUTOPSY TISSUE FROM AIDS PATIENTS, IRISH JOURNAL OF MEDICAL SCIENCE, 165, 1996, p133 - 138 Journal Article, 1996

Sheahan, B. J., Ibrahim, M. A., and Atkins, G. J. , Demyelination of olfactory pathways in mice following intranasal infection with the avirulent A7 strain of Semliki Forest virus., European Journal of Veterinary Pathology , 2, 1996, p117 - 125 Journal Article, 1996

ATKINS, GJ, SHEAHAN, BJ, LILJESTROM, P, MANIPULATION OF THE SEMLIKI FOREST VIRUS GENOME AND ITS POTENTIAL FOR VACCINE CONSTRUCTION, MOLECULAR BIOTECHNOLOGY, 5, 1996, p33 - 38 Journal Article, 1996

Mabruk, M. J. E. M. F., Flint, S. R., Coleman, D. C., Toner, M. and Atkins, G. J. , Diagnosis and treatment of oral hairy leukoplakia, of the European Academy of Dermatology and Venereology, 6, 1996, p127 - 134 Journal Article, 1996 URL DOI

Mabruk MJ, Flint SR, Coleman DC, Shiels O, Toner M, Atkins GJ., A rapid microwave-in situ hybridization method for the definitive diagnosis of oral hairy leukoplakia: comparison with immunohistochemistry., Journal of Oral Pathology & Medicine, 25, (4), 1996, p170-176 Journal Article, 1996 DOI

ATKINS, GJ, MABRUK, MJEMF, GLASGOW, GM, GRIFFIN, AM, SHEAHAN, BJ, MECHANISMS OF VIRAL TERATOGENESIS, REVIEWS IN MEDICAL VIROLOGY, 5, 1995, p75 - 86 Journal Article, 1995

Mabruk MJ, Flint SR, Toner M, Leonard N, Sheils O, Coleman DC, Atkins GJ., Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia., Journal of Oral Pathology and Medicine, 24, (3), 1995, p109-112 Journal Article, 1995 DOI

MABRUK, MJEMF, DETECTION OF EPSTEIN-BARR-VIRUS DNA IN TONGUE TISSUES FROM AIDS AUTOPSIES WITHOUT CLINICAL-EVIDENCE OF ORAL HAIRY LEUKOPLAKIA, JOURNAL OF ORAL PATHOLOGY & MEDICINE, 24, 1995, p109 - 112 Journal Article, 1995 DOI URL

ATKINS, GJ, BALLUZ, IM, GLASGOW, GM, MABRUK, MJEMF, NATALE, VAI, SMYTH, JMB, SHEAHAN, BJ, ANALYSIS OF THE MOLECULAR-BASIS OF NEUROPATHOGENESIS OF RNA VIRUSES IN EXPERIMENTAL-ANIMALS - RELEVANCE FOR HUMAN-DISEASE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 20, 1994, p91 - 102 Journal Article, 1994

Frey, T., Mitchell, L. A., Best, J. M., Schalasta, G., Katow, S., Wolinsky, J. S., Gillam, S., Atkins, G. J., Chantler, J. & Nakhasi, H. L., of an international meeting on rubella vaccines and vaccination, 9 August 1993, Glasgow, United Kingdom, Journal of Infectious Diseases , 170, 1994, p507 - 509 Journal Article, 1994

GLASGOW, GM, A SINGLE AMINO-ACID CHANGE IN THE E2 SPIKE PROTEIN OF A VIRULENT-STRAIN OF SEMLIKI-FOREST VIRUS ATTENUATES PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 75, 1994, p663 - 668 Journal Article, 1994 URL

Atkins, G. J., Society for General Microbiology symposium, 1994 Invited Talk, 1994

MABRUK, MJEMF, IN-SITU HYBRIDIZATION AND THE POLYMERASE CHAIN-REACTION (PCR) IN THE ANALYSIS OF BIOPSIES AND EXFOLIATIVE CYTOLOGY SPECIMENS FOR DEFINITIVE DIAGNOSIS OF ORAL HAIRY LEUKOPLAKIA (OHL), JOURNAL OF ORAL PATHOLOGY & MEDICINE, 23, 1994, p302 - 308 Journal Article, 1994 DOI URL

BALLUZ, IM, GLASGOW, GM, KILLEN, HM, MABRUK, MJMEF, SHEAHAN, BJ, ATKINS, GJ, VIRULENT AND AVIRULENT STRAINS OF SEMLIKI FOREST VIRUS SHOW SIMILAR CELL TROPISM FOR THE MURINE CENTRAL-NERVOUS-SYSTEM BUT DIFFER IN THE SEVERITY AND RATE OF INDUCTION OF CYTOLYTIC DAMAGE, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 19, 1993, p233 - 239 Journal Article, 1993

Natale, V. A. I., Sheahan, B. J. & Atkins, G. J. , EFFECT OF INFECTION WITH RUBELLA-VIRUS ON THE DEVELOPMENT OF RAT CEREBELLAR CELLS IN CULTURE. Neuropathology and Applied Neurobiology 19, 530-534., 1993, - Miscellaneous, 1993

BERGLUND, P, SEMLIKI FOREST VIRUS EXPRESSION SYSTEM - PRODUCTION OF CONDITIONALLY INFECTIOUS RECOMBINANT PARTICLES, BIO-TECHNOLOGY, 11, 1993, p916 - 920 Journal Article, 1993 URL DOI

Atkins, G. J., Society for General Microbiology symposium, 1992 Invited Talk, 1992

GLASGOW, GM, SHEAHAN, BJ, ATKINS, GJ, WAHLBERG, JM, SALMINEN, A, LILJESTROM, P, 2 MUTATIONS IN THE ENVELOPE GLYCOPROTEIN-E2 OF SEMLIKI FOREST VIRUS AFFECTING THE MATURATION AND ENTRY PATTERNS OF THE VIRUS ALTER PATHOGENICITY FOR MICE, VIROLOGY, 185, 1991, p741 - 748 Journal Article, 1991

ATKINS, GJ, MOONEY, DA, FAHY, DA, NG, SH, SHEAHAN, BJ, MULTIPLICATION OF RUBELLA AND MEASLES VIRUSES IN PRIMARY RAT NEURAL CELL-CULTURES - RELEVANCE TO A POSTULATED TRIGGERING MECHANISM FOR MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 17, 1991, p299 - 308 Journal Article, 1991

Atkins, G. J., American Society for Virology symposium, 1991 Invited Talk, 1991

Atkins, G. J., International Conference of Multiple Sclerosis Societies symposium, 1990 Invited Talk, 1990

ATKINS, GJ, SHEAHAN, BJ, MOONEY, DA, PATHOGENICITY OF SEMLIKI FOREST VIRUS FOR THE RAT CENTRAL-NERVOUS-SYSTEM AND PRIMARY RAT NEURAL CELL-CULTURES - POSSIBLE IMPLICATIONS FOR THE PATHOGENESIS OF MULTIPLE-SCLEROSIS, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 16, 1990, p57 - 68 Journal Article, 1990

Atkins, G. J., Daly, E. A., Sheahan, B. J., Higgins, D. G. & Sharp, P. M. , Multiple sclerosis and molecular mimicry., Neuropathology and Applied Neurobiology , 16, 1990, p179 - 180 Journal Article, 1990

SMYTH, JMB, MULTIPLICATION OF VIRULENT AND DEMYELINATING SEMLIKI FOREST VIRUS IN THE MOUSE CENTRAL-NERVOUS-SYSTEM - CONSEQUENCES IN BALB/C AND SJL MICE, JOURNAL OF GENERAL VIROLOGY, 71, 1990, p2575 - 2583 Journal Article, 1990 URL

MABRUK, MJEMF, GLASGOW, GM, FLACK, AM, FOLAN, JC, BANNIGAN, JG, SMYTH, JMB, OSULLIVAN, MA, SHEAHAN, BJ, ATKINS, GJ, EFFECT OF INFECTION WITH THE TS22 MUTANT OF SEMLIKI FOREST VIRUS ON DEVELOPMENT OF THE CENTRAL NERVOUS-SYSTEM IN THE FETAL MOUSE, JOURNAL OF VIROLOGY, 63, 1989, p4027 - 4033 Journal Article, 1989

MABRUK, MJEMF, TERATOGENICITY OF THE SEMLIKI FOREST VIRUS MUTANT TS22 FOR THE FETAL MOUSE - INDUCTION OF SKELETAL AND SKIN DEFECTS, JOURNAL OF GENERAL VIROLOGY, 69, 1988, p2755 - 2762 Journal Article, 1988 URL

HEARNE, AM, ISOLATION AND PRELIMINARY CHARACTERIZATION OF SEMLIKI FOREST VIRUS MUTANTS WITH ALTERED PATHOGENICITY FOR MOUSE EMBRYOS, JOURNAL OF GENERAL VIROLOGY, 68, 1987, p107 - 113 Journal Article, 1987 URL

HEARNE, AM, INFECTION OF CULTURED EARLY MOUSE EMBRYOS WITH SEMLIKI FOREST AND RUBELLA VIRUSES, JOURNAL OF GENERAL VIROLOGY, 67, 1986, p1091 - 1098 Journal Article, 1986 URL

GATES, MC, THE PATHOGENICITY OF THE A7-STRAIN, M9-STRAIN AND L10-STRAIN OF SEMLIKI FOREST VIRUS FOR WEANLING MICE AND PRIMARY MOUSE-BRAIN CELL-CULTURES, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p2365 - 2373 Journal Article, 1985 URL

Gates, M. C., Sheahan, B. J., O'Sullivan, M. A. & Atkins, G. J., The pathogenicity of the A7, M9 and L10 strains of Semliki Forest virus for weanling mice and primary mouse brain cell cultures., Journal of General Virology , 66, 1985, p2365 - 2373 Journal Article, 1985 URL

Atkins, G, J,, Sheahan, B. J., Dimmock, N. J., , SEMLIKI FOREST VIRUS-INFECTION OF MICE - A MODEL FOR GENETIC AND MOLECULAR ANALYSIS OF VIRAL PATHOGENICITY, JOURNAL OF GENERAL VIROLOGY, 66, 1985, p395-408 Review, 1985 URL

GATES, MC, THE PATHOGENICITY OF THE M9 MUTANT OF SEMLIKI FOREST VIRUS IN IMMUNE-COMPROMISED MICE, JOURNAL OF GENERAL VIROLOGY, 65, 1984, p73 - 80 Journal Article, 1984 URL

Atkins, G. J., Multiple sclerosis - is a virus involved? , Viral Therapeutics , 3, 1983, p1 - 2 Journal Article, 1983

SHEAHAN, BJ, GATES, MC, CAFFREY, JF, ATKINS, GJ, OLIGODENDROCYTE INFECTION AND DEMYELINATION PRODUCED IN MICE BY THE M9-MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 60, 1983, p257 - 265 Journal Article, 1983

GLASGOW, G, ATKINS, G.J., EFFECT OF PERSISTENT INFECTION ON THE GROWTH OF TUMOR-CELLS IN MICE, Irish Jurnal of Medical Science, 1983, 152, 1983, pp253 - 253 Meeting Abstract, 1983

ATKINS, GJ, THE AVIRULENT-A7 STRAIN OF SEMLIKI FOREST VIRUS HAS REDUCED CYTOPATHOGENICITY FOR NEURO-BLASTOMA CELLS COMPARED TO THE VIRULENT-L10 STRAIN, JOURNAL OF GENERAL VIROLOGY, 64, 1983, p1401 - 1404 Journal Article, 1983 URL

Atkins, G. J., Virus persistence in the central nervous system, Viral Therapeutics , 4, 1983, p6 - 7 Journal Article, 1983

ATKINS, GJ, SHEAHAN, BJ, SEMLIKE FOREST VIRUS NEUROVIRULENCE MUTANTS HAVE ALTERED CYTOPATHOGENICITY FOR CENTRAL NERVOUS-SYSTEM CELLS, INFECTION AND IMMUNITY, 36, 1982, p333 - 341 Journal Article, 1982

ATKINS, GJ, CARTER, J, SHEAHAN, BJ, EFFECT OF ALPHAVIRUS INFECTION ON MOUSE EMBRYOS, INFECTION AND IMMUNITY, 38, 1982, p1285 - 1290 Journal Article, 1982

BARRETT, PN, ESTABLISHMENT OF PERSISTENT INFECTION IN MOUSE CELLS BY SINDBIS VIRUS AND ITS TEMPERATURE-SENSITIVE MUTANTS, JOURNAL OF GENERAL VIROLOGY, 54, 1981, p57 - 65 Journal Article, 1981 URL

SHEAHAN, BJ, BARRETT, PN, ATKINS, GJ, DEMYELINATION IN MICE RESULTING FROM INFECTION WITH A MUTANT OF SEMLIKI FOREST VIRUS, ACTA NEUROPATHOLOGICA, 53, 1981, p129 - 136 Journal Article, 1981

Sheahan, B. J., Atkins, G. J., Russell, R. J. & O'Connor, J. P., Observations on two cases of histiolymphocytic lymphosarcoma in the subcutis of the horse, Veterinary Pathology , 17, 1980, p123 - 133 Journal Article, 1980

Barrett, P. N., Sheahan, B. J. & Atkins, G. J. , Isolation and preliminary characterization of mutants of Semliki Forest virus with altered virulence, Journal of General Virology , 49, 1980, p141 - 148 Journal Article, 1980 URL

Barrett, P. N. & Atkins, G. J., Virulence of temperature-sensitive mutants of Sindbis virus in neonatal mice. , Infection and Immunity , 26, 1979, p848 - 852 Journal Article, 1979

Atkins, G. J., Establishment of persistent infection in BHK-21 cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology , 45, 1979, p201 - 207 Journal Article, 1979 URL

Brezeski, H., Clegg, J. C. S., Atkins, G. J. & Kennedy, S. I. T., Regulation of the synthesis of Sindbis virus-specified RNA: role of the virion core protein, Journal of General Virology , 38, 1978, p461 - 470 Journal Article, 1978 URL

Atkins, G. J, Cytopathogenicity of temperature-sensitive mutants of Sindbis virus, FEMS Microbiology Letters , 2, 1977, p51 - 55 Journal Article, 1977

Atkins, G. J., Moynihan, M., Arbuthnott, E. & Hartigan, P. J., Detection of C-type virus in immunologically reactive ovine lymph nodes, FEMS Microbiology Letters , 2, 1977, p75 - 77 Journal Article, 1977

Atkins, G. J. & Lancashire, C. L., Interferon induction by temperature-sensitive mutants of Sindbis virus: its relationship to virus-specified double-stranded RNA synthesis and cytopathic effect, Journal of General Virology , 30, 1976, p157 - 165 Journal Article, 1976 URL

Atkins, G. J., The effect of infection with Sindbis virus and its temperature-sensitive mutants on cellular protein and DNA synthesis, Virology, 71, 1976, p593 - 597 Journal Article, 1976

Atkins, G. J. & Avery, R. J, DNA homology, redundancy and genome size of four Rhizobium bacteriophages., Journal of General Virology , 24, 1974, p301 - 306 Journal Article, 1974 URL

Atkins, G. J., Johnstone, M. D., Westmacott, L. & Burke, D. C, Induction of interferon in chick cells by temperature-sensitive mutants of Sindbis virus, Journal of General Virology, 25, 1974, p381 - 390 Journal Article, 1974 URL

Atkins, G. J., Samuels, J. & Kennedy, S. I. T, Isolation and preliminary characterization of temperature-sensitive mutants of Sindbis virus strain AR339, Journal of General Virology , 25, 1974, p371 - 380 Journal Article, 1974 URL

Atkins, G. J., Some bacteriophages active against Rhizobium trifolii strain W19., Journal of Virology , 12, 1973, p149 - 156 Journal Article, 1973 URL

Atkins, G. J. , Isolation and preliminary characterization of temperature-sensitive mutants of rhizobiophage c, Journal of Virology , 12, 1973, p157 - 164 Journal Article, 1973 URL

Atkins, G. J. & Hayes, A. E. , Surface changes in a strain of Rhizobium trifolii on mutation to bacteriophage resistance , Journal of General Microbiology , 73, 1972, p273 - 278 Journal Article, 1972

Non-Peer-Reviewed Publications

Atkins, G. J., SGM workshop on Viral Vectors, 2003, Edinburgh Meetings /Conferences Organised, 2003

Semliki Forest Virus (L10) Complete Genome, Genbank, AY112987, 2002, [Logue,C., Mooney,D., Shanley,R. and Atkins,G.J.] Item in dictionary or encyclopaedia, etc, 2002

Chikungunya Virus (Ross) Complete Genome, Genbank, AF490259, 2002, [Logue CH, Atkins GJ] Item in dictionary or encyclopaedia, etc, 2002

Research Expertise

Description

Current research interests 1.Analysis of the molecular basis of alphavirus pathogenicity: We have suggested mechanisms of teratogenesis and neurovirulence of Semliki Forest virus at the cellular level and our current work is aimed at determination of the molecular control of pathogenesis. In this work we utilise infectious clones of SFV. By using chimeric virus construction and site-directed mutagenesis, we have shown that several mutations and sequences can influence viral pathogenesis. Current work involves analysis of the mechanisms of virus-induced death in neural cells and the involvement of virus proteins in this process. 2. Analysis of the mechanism of virus-induced demyelination and its relevance to multiple sclerosis: Present work is aimed at elucidating the role of cytokines, virus persistence and apoptosis in the process of demyelination. This work has been extended to include human rubella virus (a togavirus like SFV), and we have shown that rubella virus has similar tropism in neural cell culture to SFV. 3. Use of Semliki Forest virus as a vector in the construction of viral vaccines ,as a tumour therapy agent and as a CNS vector: Virus vaccines in current use have many disadvantages and in rare cases can cause disease. We are using a vector system, developed by workers at the Karolinska Institute in Stockholm with our help, to construct new virus vaccines. This is a collaborative project with the Karolinska Institute and the Department of Veterinary Pathology at UCD, and part of our work is concerned with improvement of the biosafety of the system. This work has recently been extended to the use of SFV as a cytotoxic cancer therapy agent, and to the development of SFV as a vector for the central nervous system. New virus vectors are currently being constructed and patented.

Projects

  • Title
    • Construction and development of a new prototype measles-mumps-rubella vaccine based on recombinant RNA
  • Summary
    • € 766846
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2004
  • Date To
    • 2008
  • Title
    • Construction and development of novel and improved Semliki Forest virus vectors for RNA-based transient gene therapy
  • Summary
    • € 156321
  • Funding Agency
    • Science Foudation Ireland
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Therapy for MS
  • Summary
    • € 25125
  • Funding Agency
    • Multiple Sclerosis Society of Ireland
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Treatment of glioma using an RNA gene therapy vector
  • Summary
    • € 160000
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2005
  • Date To
    • 2009
  • Title
    • Development of a replication competent RNA vector for the treatment of advanced solid tumours
  • Summary
    • € 243473
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2006
  • Date To
    • 2009

Keywords

A7-STRAIN; ALLELE LOSS; ALPHAVIRUS; ALPHAVIRUS ENCEPHALITIS; ALPHAVIRUSES; AMINO-ACID CHANGE; ANTI-GALACTOCEREBROSIDE; ANTIBODIES; ANTIBODY; APOPTOSIS; APOPTOTIC CELLS; B-CLL; BARR VIRUS-DNA; BCL-2; BHK CELLS; BIOSAFETY; BIRNAVIRUS; BORDETELLA-PERTUSSIS; BRAIN; BURSAL DISEASE VIRUS; CANINE-DISTEMPER VIRUS; CARCINOGENESIS; CARCINOMA; CATTLE; CELL-CULTURES; CELLS; CENTRAL-NERVOUS-SYSTEM; CEREBELLUM; CERVICAL-CANCER; CHALLENGE; CULTURES; CUTANEOUS LESIONS; DEFINITIVE DIAGNOSIS; DELETION; DEMYELINATION; DENGUE; DNA; DNA VACCINES; ENVELOPE PROTEIN; EPIDERMODYSPLASIA-VERRUCIFORMIS; EPITHELIAL-CELLS; EPSTEIN-BARR VIRUS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPRESSION; GALACTOCEREBROSIDE; Gene Therapy; GENE-EXPRESSION; GENE-MUTATIONS; GENOME; GRANULE CELLS; HETEROZYGOSITY; HUMAN ESOPHAGEAL CANCER; HUMAN PAPILLOMAVIRUS; HUMORAL IMMUNE-RESPONSES; IL-12; IL-4; IMMUNE-RESPONSES; IMMUNIZATION; IMMUNOGOLD-SILVER STAINING; IMMUNOHISTOCHEMICAL DETECTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN-SITU HYBRIDIZATION; INFECTION; INSITU HYBRIDIZATION; INTERFERON-GAMMA; KI-67; LESIONS; LOSS OF HETEROZYGOSITY; LOUPING ILL VIRUS; LOW PH; MATRIX METALLOPROTEINASES; MDM2; MEMBRANE; METASTASIS; MICE; MICROWAVE IN SITU; MOLECULAR ANALYSIS; MOLECULAR PATHOGENESIS; MULTIPLE-SCLEROSIS; MURINE MODEL; MYELIN BASIC-PROTEIN; NEONATAL MICE; NEURONAL DEPLETION; NUCLEOTIDE-SEQUENCE; ORAL HAIRY LEUKOPLAKIA; P21; P53; P53 CODON 72 POLYMORPHISM; PAPILLOMAVIRUS; PLASMID DNA; PROLIFERATION INDEX; PROTECTIVE IMMUNITY; PROTEOLYTIC CLEAVAGE; RECOMBINANT VACCINES; RENAL-TRANSPLANT RECIPIENTS; RETINOBLASTOMA GENE; RISK FACTOR; SEMLIKI FOREST VIRUS; SINDBIS VIRUS; SKIN; SKIN CANCER; SPORADIC BREAST-CANCER; TICK-BORNE ENCEPHALITIS; TISSUE-SECTIONS; VECTOR; Virology

Recognition

Representations

Committee, Society for General Microbiology, Irish Branch 1978-1981, 1982-1985

Evaluation panel, Enterprise Ireland Basic Science Programme 1992,1998

EU evaluation panel, Biotechnology Programme 1996, 1997

Member, WHO working group on Biosafety of Nucleic Acid Vaccines 1999-

First and second stage evaluation panels, EU 5th Framework Programme 1999

Research Committee, Multiple Sclerosis Society of Ireland 1999-

Health Research Board Committees: Mechanisms of Disease and North-South Collaboration 2000 - 2004

GMO Advisory Committee, Environmental Protection Agency 2001

Interview panel, HRB Research Fellowships 2003

Consultant for Environmental Protection Agency (industrial use of viral vectors) 1999, 2000, 2001, 2002

Consultant for Alexander Harris, UK solicitors for vaccine-damaged children (also advisor to barristers involved in MMR litigation). 2001, 2002

Awards and Honours

UICC Fellow, Karolinska Institute, Stockholm, Sweden 1975

EMBO Fellow, University of Helsinki, Finland 1980

Fogarty International Fellow, Washington University, St. Louis, USA 1984

Fellow, Trinity College Dublin 1983

Memberships

British Society for Gene Therapy (founder member)

European Society for Gene Therapy

International Society for Neurovirology (founder member).

American Society for Microbiology

Society for General Microbiology